{"type":"journal_article","day":"01","citation":{"mla":"Kutějová, Eva, et al. “Temporal Dynamics of Patterning by Morphogen Gradients.” <i>Current Opinion in Genetics &#38; Development</i>, vol. 19, no. 4, Elsevier, 2009, pp. 315–22, doi:<a href=\"https://doi.org/10.1016/j.gde.2009.05.004\">10.1016/j.gde.2009.05.004</a>.","short":"E. Kutějová, J. Briscoe, A. Kicheva, Current Opinion in Genetics &#38; Development 19 (2009) 315–322.","ama":"Kutějová E, Briscoe J, Kicheva A. Temporal dynamics of patterning by morphogen gradients. <i>Current Opinion in Genetics &#38; Development</i>. 2009;19(4):315-322. doi:<a href=\"https://doi.org/10.1016/j.gde.2009.05.004\">10.1016/j.gde.2009.05.004</a>","apa":"Kutějová, E., Briscoe, J., &#38; Kicheva, A. (2009). Temporal dynamics of patterning by morphogen gradients. <i>Current Opinion in Genetics &#38; Development</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.gde.2009.05.004\">https://doi.org/10.1016/j.gde.2009.05.004</a>","ista":"Kutějová E, Briscoe J, Kicheva A. 2009. Temporal dynamics of patterning by morphogen gradients. Current Opinion in Genetics &#38; Development. 19(4), 315–322.","chicago":"Kutějová, Eva, James Briscoe, and Anna Kicheva. “Temporal Dynamics of Patterning by Morphogen Gradients.” <i>Current Opinion in Genetics &#38; Development</i>. Elsevier, 2009. <a href=\"https://doi.org/10.1016/j.gde.2009.05.004\">https://doi.org/10.1016/j.gde.2009.05.004</a>.","ieee":"E. Kutějová, J. Briscoe, and A. Kicheva, “Temporal dynamics of patterning by morphogen gradients,” <i>Current Opinion in Genetics &#38; Development</i>, vol. 19, no. 4. Elsevier, pp. 315–322, 2009."},"status":"public","year":"2009","extern":1,"volume":19,"_id":"1718","publication":"Current Opinion in Genetics & Development","date_updated":"2021-01-12T06:52:44Z","page":"315 - 322","date_created":"2018-12-11T11:53:38Z","date_published":"2009-08-01T00:00:00Z","abstract":[{"text":"Morphogens act as graded positional cues to control cell fate specification in many developing tissues. This concept, in which a signaling gradient regulates differential gene expression in a concentration-dependent manner, has received considerable experimental support. Nevertheless, several recent studies have challenged the straightforward model of morphogen activity. In particular, the observation that pattern formation is a dynamic process has raised questions about the influence of time on morphogen activity. Here we propose that the spatiotemporal dynamics of the cellular response to a morphogen gradient depend on a combination of temporal alterations to the morphogen gradient itself, the dynamics of its signal transduction and downstream interactions between target genes.","lang":"eng"}],"title":"Temporal dynamics of patterning by morphogen gradients","doi":"10.1016/j.gde.2009.05.004","month":"08","author":[{"first_name":"Eva","full_name":"Kutějová, Eva","last_name":"Kutějová"},{"last_name":"Briscoe","first_name":"James","full_name":"Briscoe, James"},{"id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-4509-4998","last_name":"Kicheva","full_name":"Anna Kicheva","first_name":"Anna"}],"intvolume":"        19","publication_status":"published","quality_controlled":0,"acknowledgement":"EK is supported by an EMBO LTF, AK by a FEBS fellowship, and JB by MRC (UK) and the Wellcome Trust","issue":"4","publisher":"Elsevier","publist_id":"5410"}