@article{1718, abstract = {Morphogens act as graded positional cues to control cell fate specification in many developing tissues. This concept, in which a signaling gradient regulates differential gene expression in a concentration-dependent manner, has received considerable experimental support. Nevertheless, several recent studies have challenged the straightforward model of morphogen activity. In particular, the observation that pattern formation is a dynamic process has raised questions about the influence of time on morphogen activity. Here we propose that the spatiotemporal dynamics of the cellular response to a morphogen gradient depend on a combination of temporal alterations to the morphogen gradient itself, the dynamics of its signal transduction and downstream interactions between target genes.}, author = {Kutějová, Eva and Briscoe, James and Anna Kicheva}, journal = {Current Opinion in Genetics & Development}, number = {4}, pages = {315 -- 322}, publisher = {Elsevier}, title = {{Temporal dynamics of patterning by morphogen gradients}}, doi = {10.1016/j.gde.2009.05.004}, volume = {19}, year = {2009}, }