Temporal dynamics of patterning by morphogen gradients

E. Kutějová, J. Briscoe, A. Kicheva, Current Opinion in Genetics & Development 19 (2009) 315–322.

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Abstract
Morphogens act as graded positional cues to control cell fate specification in many developing tissues. This concept, in which a signaling gradient regulates differential gene expression in a concentration-dependent manner, has received considerable experimental support. Nevertheless, several recent studies have challenged the straightforward model of morphogen activity. In particular, the observation that pattern formation is a dynamic process has raised questions about the influence of time on morphogen activity. Here we propose that the spatiotemporal dynamics of the cellular response to a morphogen gradient depend on a combination of temporal alterations to the morphogen gradient itself, the dynamics of its signal transduction and downstream interactions between target genes.
Publishing Year
Date Published
2009-08-01
Journal Title
Current Opinion in Genetics & Development
Acknowledgement
EK is supported by an EMBO LTF, AK by a FEBS fellowship, and JB by MRC (UK) and the Wellcome Trust
Volume
19
Issue
4
Page
315 - 322
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Kutějová E, Briscoe J, Kicheva A. Temporal dynamics of patterning by morphogen gradients. Current Opinion in Genetics & Development. 2009;19(4):315-322. doi:10.1016/j.gde.2009.05.004
Kutějová, E., Briscoe, J., & Kicheva, A. (2009). Temporal dynamics of patterning by morphogen gradients. Current Opinion in Genetics & Development, 19(4), 315–322. https://doi.org/10.1016/j.gde.2009.05.004
Kutějová, Eva, James Briscoe, and Anna Kicheva. “Temporal Dynamics of Patterning by Morphogen Gradients.” Current Opinion in Genetics & Development 19, no. 4 (2009): 315–22. https://doi.org/10.1016/j.gde.2009.05.004.
E. Kutějová, J. Briscoe, and A. Kicheva, “Temporal dynamics of patterning by morphogen gradients,” Current Opinion in Genetics & Development, vol. 19, no. 4, pp. 315–322, 2009.
Kutějová E, Briscoe J, Kicheva A. 2009. Temporal dynamics of patterning by morphogen gradients. Current Opinion in Genetics & Development. 19(4), 315–322.
Kutějová, Eva, et al. “Temporal Dynamics of Patterning by Morphogen Gradients.” Current Opinion in Genetics & Development, vol. 19, no. 4, Elsevier, 2009, pp. 315–22, doi:10.1016/j.gde.2009.05.004.

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