{"date_published":"2008-04-01T00:00:00Z","issue":"2","date_created":"2018-12-11T11:53:38Z","doi":"10.1016/j.ceb.2008.01.008","intvolume":"        20","title":"The Decapentaplegic morphogen gradient a precise definition","publisher":"Elsevier","publication_status":"published","day":"01","author":[{"id":"3959A2A0-F248-11E8-B48F-1D18A9856A87","last_name":"Kicheva","orcid":"0000-0003-4509-4998","full_name":"Anna Kicheva","first_name":"Anna"},{"full_name":"González-Gaitán, Marcos A","first_name":"Marcos","last_name":"González Gaitán"}],"date_updated":"2021-01-12T06:52:44Z","quality_controlled":0,"_id":"1717","abstract":[{"lang":"eng","text":"Two key processes are in the basis of morphogenesis: the spatial allocation of cell types in fields of naïve cells and the regulation of growth. Both are controlled by morphogens, which activate target genes in the growing tissue in a concentration-dependent manner. Thus the morphogen model is an intrinsically quantitative concept. However, quantitative studies were performed only in recent years on two morphogens: Bicoid and Decapentaplegic. This review covers quantitative aspects of the formation and precision of the Decapentaplegic morphogen gradient. The morphogen gradient concept is transitioning from a soft definition to a precise idea of what the gradient could really do."}],"extern":1,"status":"public","type":"journal_article","publist_id":"5412","month":"04","volume":20,"acknowledgement":"This work was supported by the University of Geneva, Max Planck Society, VW, EU, SNF, and HFSP","year":"2008","publication":"Current Opinion in Cell Biology","page":"137 - 143","citation":{"ieee":"A. Kicheva and M. González Gaitán, “The Decapentaplegic morphogen gradient a precise definition,” <i>Current Opinion in Cell Biology</i>, vol. 20, no. 2. Elsevier, pp. 137–143, 2008.","mla":"Kicheva, Anna, and Marcos González Gaitán. “The Decapentaplegic Morphogen Gradient a Precise Definition.” <i>Current Opinion in Cell Biology</i>, vol. 20, no. 2, Elsevier, 2008, pp. 137–43, doi:<a href=\"https://doi.org/10.1016/j.ceb.2008.01.008\">10.1016/j.ceb.2008.01.008</a>.","ama":"Kicheva A, González Gaitán M. The Decapentaplegic morphogen gradient a precise definition. <i>Current Opinion in Cell Biology</i>. 2008;20(2):137-143. doi:<a href=\"https://doi.org/10.1016/j.ceb.2008.01.008\">10.1016/j.ceb.2008.01.008</a>","ista":"Kicheva A, González Gaitán M. 2008. The Decapentaplegic morphogen gradient a precise definition. Current Opinion in Cell Biology. 20(2), 137–143.","apa":"Kicheva, A., &#38; González Gaitán, M. (2008). The Decapentaplegic morphogen gradient a precise definition. <i>Current Opinion in Cell Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.ceb.2008.01.008\">https://doi.org/10.1016/j.ceb.2008.01.008</a>","short":"A. Kicheva, M. González Gaitán, Current Opinion in Cell Biology 20 (2008) 137–143.","chicago":"Kicheva, Anna, and Marcos González Gaitán. “The Decapentaplegic Morphogen Gradient a Precise Definition.” <i>Current Opinion in Cell Biology</i>. Elsevier, 2008. <a href=\"https://doi.org/10.1016/j.ceb.2008.01.008\">https://doi.org/10.1016/j.ceb.2008.01.008</a>."}}