---
_id: '1715'
abstract:
- lang: eng
text: 'Background: Cell-to-cell communication at the synapse involves synaptic transmission
as well as signaling mediated by growth factors, which provide developmental and
plasticity cues. There is evidence that a retrograde, presynaptic transforming
growth factor-β (TGF-β) signaling event regulates synapse development and function
in Drosophila. Results: Here we show that a postsynaptic TGF-β signaling event
occurs during larval development. The type I receptor Thick veins (Tkv) and the
R-Smad transcription factor Mothers-against-dpp (Mad) are localized postsynaptically
in the muscle. Furthermore, Mad phosphorylation occurs in regions facing the presynaptic
active zones of neurotransmitter release within the postsynaptic subsynaptic reticulum
(SSR). In order to monitor in real time the levels of TGF-β signaling in the synapse
during synaptic transmission, we have established a FRAP assay to measure Mad
nuclear import/export in the muscle. We show that Mad nuclear trafficking depends
on stimulation of the muscle. Conclusions: Our data suggest a mechanism linking
synaptic transmission and postsynaptic TGF-β signaling that may coordinate nerve-muscle
development and function.'
acknowledgement: This work was supported by the Max Planck Society, HFSP, and Deutsche
Forschungsgemeinschaft.
article_processing_charge: No
author:
- first_name: Veronika
full_name: Dudu, Veronika
last_name: Dudu
- first_name: Thomas
full_name: Bittig, Thomas
last_name: Bittig
- first_name: Eugeni
full_name: Entchev, Eugeni
last_name: Entchev
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Frank
full_name: Julicher, Frank
last_name: Julicher
- first_name: Marcos
full_name: González Gaitán, Marcos
last_name: González Gaitán
citation:
ama: Dudu V, Bittig T, Entchev E, Kicheva A, Julicher F, González Gaitán M. Postsynaptic
mad signaling at the Drosophila neuromuscular junction. Current Biology.
2006;16(7):625-635. doi:10.1016/j.cub.2006.02.061
apa: Dudu, V., Bittig, T., Entchev, E., Kicheva, A., Julicher, F., & González
Gaitán, M. (2006). Postsynaptic mad signaling at the Drosophila neuromuscular
junction. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2006.02.061
chicago: Dudu, Veronika, Thomas Bittig, Eugeni Entchev, Anna Kicheva, Frank Julicher,
and Marcos González Gaitán. “Postsynaptic Mad Signaling at the Drosophila Neuromuscular
Junction.” Current Biology. Cell Press, 2006. https://doi.org/10.1016/j.cub.2006.02.061.
ieee: V. Dudu, T. Bittig, E. Entchev, A. Kicheva, F. Julicher, and M. González Gaitán,
“Postsynaptic mad signaling at the Drosophila neuromuscular junction,” Current
Biology, vol. 16, no. 7. Cell Press, pp. 625–635, 2006.
ista: Dudu V, Bittig T, Entchev E, Kicheva A, Julicher F, González Gaitán M. 2006.
Postsynaptic mad signaling at the Drosophila neuromuscular junction. Current Biology.
16(7), 625–635.
mla: Dudu, Veronika, et al. “Postsynaptic Mad Signaling at the Drosophila Neuromuscular
Junction.” Current Biology, vol. 16, no. 7, Cell Press, 2006, pp. 625–35,
doi:10.1016/j.cub.2006.02.061.
short: V. Dudu, T. Bittig, E. Entchev, A. Kicheva, F. Julicher, M. González Gaitán,
Current Biology 16 (2006) 625–635.
date_created: 2018-12-11T11:53:37Z
date_published: 2006-04-04T00:00:00Z
date_updated: 2021-11-16T07:44:15Z
day: '04'
doi: 10.1016/j.cub.2006.02.061
extern: '1'
intvolume: ' 16'
issue: '7'
language:
- iso: eng
month: '04'
oa_version: None
page: 625 - 635
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '5416'
related_material:
link:
- relation: erratum
url: https://doi.org/10.1016/j.cub.2006.06.020
status: public
title: Postsynaptic mad signaling at the Drosophila neuromuscular junction
type: journal_article
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 16
year: '2006'
...