---
_id: '1699'
abstract:
- lang: eng
text: By hybridization and backcrossing, alleles can surmount species boundaries
and be incorporated into the genome of a related species. This introgression of
genes is of particular evolutionary relevance if it involves the transfer of adaptations
between populations. However, any beneficial allele will typically be associated
with other alien alleles that are often deleterious and hamper the introgression
process. In order to describe the introgression of an adaptive allele, we set
up a stochastic model with an explicit genetic makeup of linked and unlinked deleterious
alleles. Based on the theory of reducible multitype branching processes, we derive
a recursive expression for the establishment probability of the beneficial allele
after a single hybridization event. We furthermore study the probability that
slightly deleterious alleles hitchhike to fixation. The key to the analysis is
a split of the process into a stochastic phase in which the advantageous alleles
establishes and a deterministic phase in which it sweeps to fixation. We thereafter
apply the theory to a set of biologically relevant scenarios such as introgression
in the presence of many unlinked or few closely linked deleterious alleles. A
comparison to computer simulations shows that the approximations work well over
a large parameter range.
acknowledgement: This work was made possible with financial support by the Vienna
Science and Technology Fund (WWTF), by the Deutsche Forschungsgemeinschaft (DFG),
Research Unit 1078 Natural selection in structured populations, by the Austrian
Science Fund (FWF) via funding for the Vienna Graduate School for Population Genetics,
and by a “For Women in Science” fellowship (L’Oréal Österreich in cooperation with
the Austrian Commission for UNESCO and the Austrian Academy of Sciences with financial
support from the Federal Ministry for Science and Research Austria).
author:
- first_name: Hildegard
full_name: Uecker, Hildegard
id: 2DB8F68A-F248-11E8-B48F-1D18A9856A87
last_name: Uecker
orcid: 0000-0001-9435-2813
- first_name: Derek
full_name: Setter, Derek
last_name: Setter
- first_name: Joachim
full_name: Hermisson, Joachim
last_name: Hermisson
citation:
ama: Uecker H, Setter D, Hermisson J. Adaptive gene introgression after secondary
contact. Journal of Mathematical Biology. 2015;70(7):1523-1580. doi:10.1007/s00285-014-0802-y
apa: Uecker, H., Setter, D., & Hermisson, J. (2015). Adaptive gene introgression
after secondary contact. Journal of Mathematical Biology. Springer. https://doi.org/10.1007/s00285-014-0802-y
chicago: Uecker, Hildegard, Derek Setter, and Joachim Hermisson. “Adaptive Gene
Introgression after Secondary Contact.” Journal of Mathematical Biology.
Springer, 2015. https://doi.org/10.1007/s00285-014-0802-y.
ieee: H. Uecker, D. Setter, and J. Hermisson, “Adaptive gene introgression after
secondary contact,” Journal of Mathematical Biology, vol. 70, no. 7. Springer,
pp. 1523–1580, 2015.
ista: Uecker H, Setter D, Hermisson J. 2015. Adaptive gene introgression after secondary
contact. Journal of Mathematical Biology. 70(7), 1523–1580.
mla: Uecker, Hildegard, et al. “Adaptive Gene Introgression after Secondary Contact.”
Journal of Mathematical Biology, vol. 70, no. 7, Springer, 2015, pp. 1523–80,
doi:10.1007/s00285-014-0802-y.
short: H. Uecker, D. Setter, J. Hermisson, Journal of Mathematical Biology 70 (2015)
1523–1580.
date_created: 2018-12-11T11:53:32Z
date_published: 2015-06-01T00:00:00Z
date_updated: 2023-02-23T10:10:36Z
day: '01'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1007/s00285-014-0802-y
file:
- access_level: open_access
checksum: 00e3a67bda05d4cc165b3a48b41ef9ad
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:14:27Z
date_updated: 2020-07-14T12:45:12Z
file_id: '5079'
file_name: IST-2016-458-v1+1_s00285-014-0802-y.pdf
file_size: 1321527
relation: main_file
file_date_updated: 2020-07-14T12:45:12Z
has_accepted_license: '1'
intvolume: ' 70'
issue: '7'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 1523 - 1580
project:
- _id: 25B67606-B435-11E9-9278-68D0E5697425
name: L'OREAL Fellowship
publication: Journal of Mathematical Biology
publication_status: published
publisher: Springer
publist_id: '5442'
pubrep_id: '458'
quality_controlled: '1'
scopus_import: 1
status: public
title: Adaptive gene introgression after secondary contact
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 70
year: '2015'
...