{"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","language":[{"iso":"eng"}],"department":[{"_id":"LeSa"}],"intvolume":"        33","title":"Gaining mass: The structure of respiratory complex I-from bacterial towards mitochondrial versions","month":"08","author":[{"last_name":"Letts","orcid":"0000-0002-9864-3586","full_name":"Letts, Jame A","first_name":"Jame A","id":"322DA418-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Leonid A","id":"338D39FE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0977-7989","last_name":"Sazanov","full_name":"Sazanov, Leonid A"}],"date_created":"2018-12-11T11:53:27Z","publist_id":"5465","doi":"10.1016/j.sbi.2015.08.008","abstract":[{"text":"The 1 MDa, 45-subunit proton-pumping NADH-ubiquinone oxidoreductase (complex I) is the largest complex of the mitochondrial electron transport chain. The molecular mechanism of complex I is central to the metabolism of cells, but has yet to be fully characterized. The last two years have seen steady progress towards this goal with the first atomic-resolution structure of the entire bacterial complex I, a 5 Å cryo-electron microscopy map of bovine mitochondrial complex I and a ∼3.8 Å resolution X-ray crystallographic study of mitochondrial complex I from yeast Yarrowia lipotytica. In this review we will discuss what we have learned from these studies and what remains to be elucidated.","lang":"eng"}],"date_published":"2015-08-01T00:00:00Z","citation":{"ama":"Letts JA, Sazanov LA. Gaining mass: The structure of respiratory complex I-from bacterial towards mitochondrial versions. <i>Current Opinion in Structural Biology</i>. 2015;33(8):135-145. doi:<a href=\"https://doi.org/10.1016/j.sbi.2015.08.008\">10.1016/j.sbi.2015.08.008</a>","apa":"Letts, J. A., &#38; Sazanov, L. A. (2015). Gaining mass: The structure of respiratory complex I-from bacterial towards mitochondrial versions. <i>Current Opinion in Structural Biology</i>. Elsevier. <a href=\"https://doi.org/10.1016/j.sbi.2015.08.008\">https://doi.org/10.1016/j.sbi.2015.08.008</a>","ieee":"J. A. Letts and L. A. Sazanov, “Gaining mass: The structure of respiratory complex I-from bacterial towards mitochondrial versions,” <i>Current Opinion in Structural Biology</i>, vol. 33, no. 8. Elsevier, pp. 135–145, 2015.","ista":"Letts JA, Sazanov LA. 2015. Gaining mass: The structure of respiratory complex I-from bacterial towards mitochondrial versions. Current Opinion in Structural Biology. 33(8), 135–145.","chicago":"Letts, James A, and Leonid A Sazanov. “Gaining Mass: The Structure of Respiratory Complex I-from Bacterial towards Mitochondrial Versions.” <i>Current Opinion in Structural Biology</i>. Elsevier, 2015. <a href=\"https://doi.org/10.1016/j.sbi.2015.08.008\">https://doi.org/10.1016/j.sbi.2015.08.008</a>.","mla":"Letts, James A., and Leonid A. Sazanov. “Gaining Mass: The Structure of Respiratory Complex I-from Bacterial towards Mitochondrial Versions.” <i>Current Opinion in Structural Biology</i>, vol. 33, no. 8, Elsevier, 2015, pp. 135–45, doi:<a href=\"https://doi.org/10.1016/j.sbi.2015.08.008\">10.1016/j.sbi.2015.08.008</a>.","short":"J.A. Letts, L.A. Sazanov, Current Opinion in Structural Biology 33 (2015) 135–145."},"volume":33,"publisher":"Elsevier","publication":"Current Opinion in Structural Biology","_id":"1683","status":"public","type":"journal_article","publication_status":"published","day":"01","quality_controlled":"1","date_updated":"2021-01-12T06:52:30Z","oa_version":"None","scopus_import":1,"page":"135 - 145","year":"2015","issue":"8"}