{"oa":1,"_id":"1618","scopus_import":"1","publication_status":"published","language":[{"iso":"eng"}],"publication":"Biochemistry","date_created":"2018-12-11T11:53:03Z","volume":54,"abstract":[{"lang":"eng","text":"CCL19 and CCL21 are chemokines involved in the trafficking of immune cells, particularly within the lymphatic system, through activation of CCR7. Concurrent expression of PSGL-1 and CCR7 in naive T-cells enhances recruitment of these cells to secondary lymphoid organs by CCL19 and CCL21. Here the solution structure of CCL19 is reported. It contains a canonical chemokine domain. Chemical shift mapping shows the N-termini of PSGL-1 and CCR7 have overlapping binding sites for CCL19 and binding is competitive. Implications for the mechanism of PSGL-1's enhancement of resting T-cell recruitment are discussed."}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","article_processing_charge":"No","day":"26","publisher":"American Chemical Society","department":[{"_id":"MiSi"}],"pmid":1,"page":"4163 - 4166","type":"journal_article","doi":"10.1021/acs.biochem.5b00560","issue":"27","external_id":{"pmid":["26115234"]},"status":"public","author":[{"first_name":"Christopher","last_name":"Veldkamp","full_name":"Veldkamp, Christopher"},{"orcid":"0000-0001-6165-5738","first_name":"Eva","last_name":"Kiermaier","full_name":"Kiermaier, Eva","id":"3EB04B78-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Gabel Eissens, Skylar","last_name":"Gabel Eissens","first_name":"Skylar"},{"first_name":"Miranda","last_name":"Gillitzer","full_name":"Gillitzer, Miranda"},{"full_name":"Lippner, David","first_name":"David","last_name":"Lippner"},{"full_name":"Disilvio, Frank","first_name":"Frank","last_name":"Disilvio"},{"full_name":"Mueller, Casey","last_name":"Mueller","first_name":"Casey"},{"full_name":"Wantuch, Paeton","first_name":"Paeton","last_name":"Wantuch"},{"full_name":"Chaffee, Gary","first_name":"Gary","last_name":"Chaffee"},{"full_name":"Famiglietti, Michael","first_name":"Michael","last_name":"Famiglietti"},{"last_name":"Zgoba","first_name":"Danielle","full_name":"Zgoba, Danielle"},{"full_name":"Bailey, Asha","first_name":"Asha","last_name":"Bailey"},{"full_name":"Bah, Yaya","last_name":"Bah","first_name":"Yaya"},{"first_name":"Samantha","last_name":"Engebretson","full_name":"Engebretson, Samantha"},{"first_name":"David","last_name":"Graupner","full_name":"Graupner, David"},{"full_name":"Lackner, Emily","last_name":"Lackner","first_name":"Emily"},{"full_name":"Larosa, Vincent","first_name":"Vincent","last_name":"Larosa"},{"full_name":"Medeiros, Tysha","first_name":"Tysha","last_name":"Medeiros"},{"full_name":"Olson, Michael","first_name":"Michael","last_name":"Olson"},{"full_name":"Phillips, Andrew","last_name":"Phillips","first_name":"Andrew"},{"full_name":"Pyles, Harley","last_name":"Pyles","first_name":"Harley"},{"full_name":"Richard, Amanda","last_name":"Richard","first_name":"Amanda"},{"full_name":"Schoeller, Scott","last_name":"Schoeller","first_name":"Scott"},{"first_name":"Boris","last_name":"Touzeau","full_name":"Touzeau, Boris"},{"full_name":"Williams, Larry","first_name":"Larry","last_name":"Williams"},{"full_name":"Sixt, Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","first_name":"Michael K","orcid":"0000-0002-6620-9179","last_name":"Sixt"},{"first_name":"Francis","last_name":"Peterson","full_name":"Peterson, Francis"}],"oa_version":"Submitted Version","date_updated":"2023-03-30T11:32:57Z","publist_id":"5548","ec_funded":1,"month":"06","year":"2015","title":"Solution structure of CCL19 and identification of overlapping CCR7 and PSGL-1 binding sites","quality_controlled":"1","project":[{"call_identifier":"FP7","name":"Cytoskeletal force generation and force transduction of migrating leukocytes (EU)","grant_number":"281556","_id":"25A603A2-B435-11E9-9278-68D0E5697425"}],"main_file_link":[{"url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4809050/","open_access":"1"}],"intvolume":"        54","date_published":"2015-06-26T00:00:00Z","citation":{"ama":"Veldkamp C, Kiermaier E, Gabel Eissens S, et al. Solution structure of CCL19 and identification of overlapping CCR7 and PSGL-1 binding sites. <i>Biochemistry</i>. 2015;54(27):4163-4166. doi:<a href=\"https://doi.org/10.1021/acs.biochem.5b00560\">10.1021/acs.biochem.5b00560</a>","ieee":"C. Veldkamp <i>et al.</i>, “Solution structure of CCL19 and identification of overlapping CCR7 and PSGL-1 binding sites,” <i>Biochemistry</i>, vol. 54, no. 27. American Chemical Society, pp. 4163–4166, 2015.","short":"C. Veldkamp, E. Kiermaier, S. Gabel Eissens, M. Gillitzer, D. Lippner, F. Disilvio, C. Mueller, P. Wantuch, G. Chaffee, M. Famiglietti, D. Zgoba, A. Bailey, Y. Bah, S. Engebretson, D. Graupner, E. Lackner, V. Larosa, T. Medeiros, M. Olson, A. Phillips, H. Pyles, A. Richard, S. Schoeller, B. Touzeau, L. Williams, M.K. Sixt, F. Peterson, Biochemistry 54 (2015) 4163–4166.","mla":"Veldkamp, Christopher, et al. “Solution Structure of CCL19 and Identification of Overlapping CCR7 and PSGL-1 Binding Sites.” <i>Biochemistry</i>, vol. 54, no. 27, American Chemical Society, 2015, pp. 4163–66, doi:<a href=\"https://doi.org/10.1021/acs.biochem.5b00560\">10.1021/acs.biochem.5b00560</a>.","apa":"Veldkamp, C., Kiermaier, E., Gabel Eissens, S., Gillitzer, M., Lippner, D., Disilvio, F., … Peterson, F. (2015). Solution structure of CCL19 and identification of overlapping CCR7 and PSGL-1 binding sites. <i>Biochemistry</i>. American Chemical Society. <a href=\"https://doi.org/10.1021/acs.biochem.5b00560\">https://doi.org/10.1021/acs.biochem.5b00560</a>","ista":"Veldkamp C, Kiermaier E, Gabel Eissens S, Gillitzer M, Lippner D, Disilvio F, Mueller C, Wantuch P, Chaffee G, Famiglietti M, Zgoba D, Bailey A, Bah Y, Engebretson S, Graupner D, Lackner E, Larosa V, Medeiros T, Olson M, Phillips A, Pyles H, Richard A, Schoeller S, Touzeau B, Williams L, Sixt MK, Peterson F. 2015. Solution structure of CCL19 and identification of overlapping CCR7 and PSGL-1 binding sites. Biochemistry. 54(27), 4163–4166.","chicago":"Veldkamp, Christopher, Eva Kiermaier, Skylar Gabel Eissens, Miranda Gillitzer, David Lippner, Frank Disilvio, Casey Mueller, et al. “Solution Structure of CCL19 and Identification of Overlapping CCR7 and PSGL-1 Binding Sites.” <i>Biochemistry</i>. American Chemical Society, 2015. <a href=\"https://doi.org/10.1021/acs.biochem.5b00560\">https://doi.org/10.1021/acs.biochem.5b00560</a>."}}