--- res: bibo_abstract: - Auxin participates in a multitude of developmental processes, as well as responses to environmental cues. Compared with other plant hormones, auxin exhibits a unique property, as it undergoes directional, cell-to-cell transport facilitated by plasma membrane-localized transport proteins. Among them, a prominent role has been ascribed to the PIN family of auxin efflux facilitators. PIN proteins direct polar auxin transport on account of their asymmetric subcellular localizations. In this review, we provide an overview of the multiple developmental roles of PIN proteins, including the atypical endoplasmic reticulum-localized members of the family, and look at the family from an evolutionary perspective. Next, we cover the cell biological and molecular aspects of PIN function, in particular the establishment of their polar subcellular localization. Hormonal and environmental inputs into the regulation of PIN action are summarized as well.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Maciek foaf_name: Adamowski, Maciek foaf_surname: Adamowski foaf_workInfoHomepage: http://www.librecat.org/personId=45F536D2-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-6463-5257 - foaf_Person: foaf_givenName: Jirí foaf_name: Friml, Jirí foaf_surname: Friml foaf_workInfoHomepage: http://www.librecat.org/personId=4159519E-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-8302-7596 bibo_doi: 10.1105/tpc.114.134874 bibo_issue: '1' bibo_volume: 27 dct_date: 2015^xs_gYear dct_language: eng dct_publisher: American Society of Plant Biologists@ dct_title: 'PIN-dependent auxin transport: Action, regulation, and evolution@' fabio_hasPubmedId: '25604445' ...