{"_id":"1396","ddc":["570"],"supervisor":[{"last_name":"Jonas","full_name":"Jonas, Peter M","first_name":"Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}],"date_published":"2016-03-01T00:00:00Z","oa":1,"year":"2016","file_date_updated":"2021-02-22T11:48:44Z","publication_status":"published","has_accepted_license":"1","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publist_id":"5811","day":"01","date_updated":"2023-09-07T11:55:26Z","citation":{"apa":"Mishra, R. K. (2016). <i>Synaptic plasticity rules at CA3-CA3 recurrent synapses in hippocampus</i>. Institute of Science and Technology Austria.","mla":"Mishra, Rajiv Kumar. <i>Synaptic Plasticity Rules at CA3-CA3 Recurrent Synapses in Hippocampus</i>. Institute of Science and Technology Austria, 2016.","short":"R.K. Mishra, Synaptic Plasticity Rules at CA3-CA3 Recurrent Synapses in Hippocampus, Institute of Science and Technology Austria, 2016.","chicago":"Mishra, Rajiv Kumar. “Synaptic Plasticity Rules at CA3-CA3 Recurrent Synapses in Hippocampus.” Institute of Science and Technology Austria, 2016.","ista":"Mishra RK. 2016. Synaptic plasticity rules at CA3-CA3 recurrent synapses in hippocampus. Institute of Science and Technology Austria.","ieee":"R. K. Mishra, “Synaptic plasticity rules at CA3-CA3 recurrent synapses in hippocampus,” Institute of Science and Technology Austria, 2016.","ama":"Mishra RK. Synaptic plasticity rules at CA3-CA3 recurrent synapses in hippocampus. 2016."},"month":"03","abstract":[{"lang":"eng","text":"CA3 pyramidal neurons are thought to pay a key role in memory storage and pattern completion by activity-dependent synaptic plasticity between CA3-CA3 recurrent excitatory synapses. To examine the induction rules of synaptic plasticity at CA3-CA3 synapses, we performed whole-cell patch-clamp recordings in acute hippocampal slices from rats (postnatal 21-24 days) at room temperature. Compound excitatory postsynaptic potentials (ESPSs) were recorded by tract stimulation in stratum oriens in the presence of 10 µM gabazine. High-frequency stimulation (HFS) induced N-methyl-D-aspartate (NMDA) receptor-dependent long-term potentiation (LTP). Although LTP by HFS did not requier postsynaptic spikes, it was blocked by Na+-channel blockers suggesting that local active processes (e.g.) dendritic spikes) may contribute to LTP induction without requirement of a somatic action potential (AP). We next examined the properties of spike timing-dependent plasticity (STDP) at CA3-CA3 synapses. Unexpectedly, low-frequency pairing of EPSPs and backpropagated action potentialy (bAPs) induced LTP, independent of temporal order. The STDP curve was symmetric and broad, with a half-width of ~150 ms. Consistent with these specific STDP induction properties, post-presynaptic sequences led to a supralinear summation of spine [Ca2+] transients. Furthermore, in autoassociative network models, storage and recall was substantially more robust with symmetric than with asymmetric STDP rules. In conclusion, we found associative forms of LTP at CA3-CA3 recurrent collateral synapses with distinct induction rules. LTP induced by HFS may be associated with dendritic spikes. In contrast, low frequency pairing of pre- and postsynaptic activity induced LTP only if EPSP-AP were temporally very close. Together, these induction mechanisms of synaptiic plasticity may contribute to memory storage in the CA3-CA3 microcircuit at different ranges of activity."}],"language":[{"iso":"eng"}],"degree_awarded":"PhD","article_processing_charge":"No","file":[{"creator":"dernst","access_level":"closed","relation":"main_file","file_name":"Thesis_Mishra_Rajiv (Final).pdf","file_size":2407572,"date_updated":"2020-07-14T12:44:48Z","content_type":"application/pdf","checksum":"5a010a838faf040f7064f3cfb802f743","date_created":"2019-08-09T12:14:46Z","file_id":"6782"},{"checksum":"81b26d9ede92c99f1d8cc6fa1d04cbbb","content_type":"application/pdf","file_id":"9183","date_created":"2021-02-22T11:48:44Z","relation":"main_file","access_level":"open_access","creator":"dernst","success":1,"date_updated":"2021-02-22T11:48:44Z","file_size":2407572,"file_name":"2016_RajivMishra_Thesis.pdf"}],"date_created":"2018-12-11T11:51:46Z","title":"Synaptic plasticity rules at CA3-CA3 recurrent synapses in hippocampus","oa_version":"Published Version","page":"83","type":"dissertation","author":[{"id":"46CB58F2-F248-11E8-B48F-1D18A9856A87","full_name":"Mishra, Rajiv Kumar","last_name":"Mishra","first_name":"Rajiv Kumar"}],"alternative_title":["ISTA Thesis"],"status":"public","department":[{"_id":"PeJo"}],"publisher":"Institute of Science and Technology Austria","related_material":{"record":[{"id":"1432","status":"public","relation":"part_of_dissertation"}]},"publication_identifier":{"issn":["2663-337X"]}}