---
_id: '1371'
abstract:
- lang: eng
text: Living cells can maintain their internal states, react to changing environments,
grow, differentiate, divide, etc. All these processes are tightly controlled by
what can be called a regulatory program. The logic of the underlying control can
sometimes be guessed at by examining the network of influences amongst genetic
components. Some associated gene regulatory networks have been studied in prokaryotes
and eukaryotes, unveiling various structural features ranging from broad distributions
of out-degrees to recurrent "motifs", that is small subgraphs having
a specific pattern of interactions. To understand what factors may be driving
such structuring, a number of groups have introduced frameworks to model the dynamics
of gene regulatory networks. In that context, we review here such in silico approaches
and show how selection for phenotypes, i.e., network function, can shape network
structure.
acknowledgement: 'MZ has been supported by Polish National Science Centre Grant No.
DEC-2012/07/N/NZ2/00107 and by Foundation of Polish Science award START. '
author:
- first_name: Olivier
full_name: Martin, Olivier
last_name: Martin
- first_name: André
full_name: Krzywicki, André
last_name: Krzywicki
- first_name: Marcin P
full_name: Zagórski, Marcin P
id: 343DA0DC-F248-11E8-B48F-1D18A9856A87
last_name: Zagórski
orcid: 0000-0001-7896-7762
citation:
ama: 'Martin O, Krzywicki A, Zagórski MP. Drivers of structural features in gene
regulatory networks: From biophysical constraints to biological function. Physics
of Life Reviews. 2016;17:124-158. doi:10.1016/j.plrev.2016.06.002'
apa: 'Martin, O., Krzywicki, A., & Zagórski, M. P. (2016). Drivers of structural
features in gene regulatory networks: From biophysical constraints to biological
function. Physics of Life Reviews. Elsevier. https://doi.org/10.1016/j.plrev.2016.06.002'
chicago: 'Martin, Olivier, André Krzywicki, and Marcin P Zagórski. “Drivers of Structural
Features in Gene Regulatory Networks: From Biophysical Constraints to Biological
Function.” Physics of Life Reviews. Elsevier, 2016. https://doi.org/10.1016/j.plrev.2016.06.002.'
ieee: 'O. Martin, A. Krzywicki, and M. P. Zagórski, “Drivers of structural features
in gene regulatory networks: From biophysical constraints to biological function,”
Physics of Life Reviews, vol. 17. Elsevier, pp. 124–158, 2016.'
ista: 'Martin O, Krzywicki A, Zagórski MP. 2016. Drivers of structural features
in gene regulatory networks: From biophysical constraints to biological function.
Physics of Life Reviews. 17, 124–158.'
mla: 'Martin, Olivier, et al. “Drivers of Structural Features in Gene Regulatory
Networks: From Biophysical Constraints to Biological Function.” Physics of
Life Reviews, vol. 17, Elsevier, 2016, pp. 124–58, doi:10.1016/j.plrev.2016.06.002.'
short: O. Martin, A. Krzywicki, M.P. Zagórski, Physics of Life Reviews 17 (2016)
124–158.
date_created: 2018-12-11T11:51:38Z
date_published: 2016-07-01T00:00:00Z
date_updated: 2021-01-12T06:50:13Z
day: '01'
department:
- _id: AnKi
doi: 10.1016/j.plrev.2016.06.002
ec_funded: 1
intvolume: ' 17'
language:
- iso: eng
month: '07'
oa_version: None
page: 124 - 158
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Physics of Life Reviews
publication_status: published
publisher: Elsevier
publist_id: '5840'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Drivers of structural features in gene regulatory networks: From biophysical
constraints to biological function'
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 17
year: '2016'
...