--- _id: '1371' abstract: - lang: eng text: Living cells can maintain their internal states, react to changing environments, grow, differentiate, divide, etc. All these processes are tightly controlled by what can be called a regulatory program. The logic of the underlying control can sometimes be guessed at by examining the network of influences amongst genetic components. Some associated gene regulatory networks have been studied in prokaryotes and eukaryotes, unveiling various structural features ranging from broad distributions of out-degrees to recurrent "motifs", that is small subgraphs having a specific pattern of interactions. To understand what factors may be driving such structuring, a number of groups have introduced frameworks to model the dynamics of gene regulatory networks. In that context, we review here such in silico approaches and show how selection for phenotypes, i.e., network function, can shape network structure. acknowledgement: 'MZ has been supported by Polish National Science Centre Grant No. DEC-2012/07/N/NZ2/00107 and by Foundation of Polish Science award START. ' author: - first_name: Olivier full_name: Martin, Olivier last_name: Martin - first_name: André full_name: Krzywicki, André last_name: Krzywicki - first_name: Marcin P full_name: Zagórski, Marcin P id: 343DA0DC-F248-11E8-B48F-1D18A9856A87 last_name: Zagórski orcid: 0000-0001-7896-7762 citation: ama: 'Martin O, Krzywicki A, Zagórski MP. Drivers of structural features in gene regulatory networks: From biophysical constraints to biological function. Physics of Life Reviews. 2016;17:124-158. doi:10.1016/j.plrev.2016.06.002' apa: 'Martin, O., Krzywicki, A., & Zagórski, M. P. (2016). Drivers of structural features in gene regulatory networks: From biophysical constraints to biological function. Physics of Life Reviews. Elsevier. https://doi.org/10.1016/j.plrev.2016.06.002' chicago: 'Martin, Olivier, André Krzywicki, and Marcin P Zagórski. “Drivers of Structural Features in Gene Regulatory Networks: From Biophysical Constraints to Biological Function.” Physics of Life Reviews. Elsevier, 2016. https://doi.org/10.1016/j.plrev.2016.06.002.' ieee: 'O. Martin, A. Krzywicki, and M. P. Zagórski, “Drivers of structural features in gene regulatory networks: From biophysical constraints to biological function,” Physics of Life Reviews, vol. 17. Elsevier, pp. 124–158, 2016.' ista: 'Martin O, Krzywicki A, Zagórski MP. 2016. Drivers of structural features in gene regulatory networks: From biophysical constraints to biological function. Physics of Life Reviews. 17, 124–158.' mla: 'Martin, Olivier, et al. “Drivers of Structural Features in Gene Regulatory Networks: From Biophysical Constraints to Biological Function.” Physics of Life Reviews, vol. 17, Elsevier, 2016, pp. 124–58, doi:10.1016/j.plrev.2016.06.002.' short: O. Martin, A. Krzywicki, M.P. Zagórski, Physics of Life Reviews 17 (2016) 124–158. date_created: 2018-12-11T11:51:38Z date_published: 2016-07-01T00:00:00Z date_updated: 2021-01-12T06:50:13Z day: '01' department: - _id: AnKi doi: 10.1016/j.plrev.2016.06.002 ec_funded: 1 intvolume: ' 17' language: - iso: eng month: '07' oa_version: None page: 124 - 158 project: - _id: 25681D80-B435-11E9-9278-68D0E5697425 call_identifier: FP7 grant_number: '291734' name: International IST Postdoc Fellowship Programme publication: Physics of Life Reviews publication_status: published publisher: Elsevier publist_id: '5840' quality_controlled: '1' scopus_import: 1 status: public title: 'Drivers of structural features in gene regulatory networks: From biophysical constraints to biological function' type: journal_article user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87 volume: 17 year: '2016' ...