Optogenetic control of fly optomotor responses

V. Haikala, M.A. Jösch, A. Borst, A. Mauss, Journal of Neuroscience 33 (2013) 13927–13934.

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Abstract
When confronted with a large-field stimulus rotating around the vertical body axis, flies display a following behavior called "optomotor response." As neural control elements, the large tangential horizontal system (HS) cells of the lobula plate have been prime candidates for long. Here, we applied optogenetic stimulation of HS cells to evaluate their behavioral role in Drosophila. To minimize interference of the optical activation of channelrhodopsin-2 with the visual perception of the flies, we used a bistable variant called ChR2-C128S. By applying pulses of blue and yellow light, we first demonstrate electrophysiologically that lobula plate tangential cells can be activated and deactivated repeatedly with no evident change in depolarization strength over trials. We next show that selective optogenetic activation of HS cells elicits robust yaw head movements and yaw turning responses in fixed and tethered flying flies, respectively.
Publishing Year
Date Published
2013-01-01
Journal Title
Journal of Neuroscience
Acknowledgement
This work was supported by the Max Planck Society.
Volume
33
Issue
34
Page
13927 - 13934
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Haikala V, Jösch MA, Borst A, Mauss A. Optogenetic control of fly optomotor responses. Journal of Neuroscience. 2013;33(34):13927-13934. doi:10.1523/JNEUROSCI.0340-13.2013
Haikala, V., Jösch, M. A., Borst, A., & Mauss, A. (2013). Optogenetic control of fly optomotor responses. Journal of Neuroscience, 33(34), 13927–13934. https://doi.org/10.1523/JNEUROSCI.0340-13.2013
Haikala, Väinö, Maximilian A Jösch, Alexander Borst, and Alex Mauss. “Optogenetic Control of Fly Optomotor Responses.” Journal of Neuroscience 33, no. 34 (2013): 13927–34. https://doi.org/10.1523/JNEUROSCI.0340-13.2013.
V. Haikala, M. A. Jösch, A. Borst, and A. Mauss, “Optogenetic control of fly optomotor responses,” Journal of Neuroscience, vol. 33, no. 34, pp. 13927–13934, 2013.
Haikala V, Jösch MA, Borst A, Mauss A. 2013. Optogenetic control of fly optomotor responses. Journal of Neuroscience. 33(34), 13927–13934.
Haikala, Väinö, et al. “Optogenetic Control of Fly Optomotor Responses.” Journal of Neuroscience, vol. 33, no. 34, Society for Neuroscience, 2013, pp. 13927–34, doi:10.1523/JNEUROSCI.0340-13.2013.

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