---
_id: '11088'
abstract:
- lang: eng
text: 'The crowded intracellular environment poses a formidable challenge to experimental
and theoretical analyses of intracellular transport mechanisms. Our measurements
of single-particle trajectories in cytoplasm and their random-walk interpretations
elucidate two of these mechanisms: molecular diffusion in crowded environments
and cytoskeletal transport along microtubules. We employed acousto-optic deflector
microscopy to map out the three-dimensional trajectories of microspheres migrating
in the cytosolic fraction of a cellular extract. Classical Brownian motion (BM),
continuous time random walk, and fractional BM were alternatively used to represent
these trajectories. The comparison of the experimental and numerical data demonstrates
that cytoskeletal transport along microtubules and diffusion in the cytosolic
fraction exhibit anomalous (nonFickian) behavior and posses statistically distinct
signatures. Among the three random-walk models used, continuous time random walk
provides the best representation of diffusion, whereas microtubular transport
is accurately modeled with fractional BM.'
article_processing_charge: No
article_type: original
author:
- first_name: Benjamin M.
full_name: Regner, Benjamin M.
last_name: Regner
- first_name: Dejan
full_name: Vučinić, Dejan
last_name: Vučinić
- first_name: Cristina
full_name: Domnisoru, Cristina
last_name: Domnisoru
- first_name: Thomas M.
full_name: Bartol, Thomas M.
last_name: Bartol
- first_name: Martin W
full_name: HETZER, Martin W
id: 86c0d31b-b4eb-11ec-ac5a-eae7b2e135ed
last_name: HETZER
orcid: 0000-0002-2111-992X
- first_name: Daniel M.
full_name: Tartakovsky, Daniel M.
last_name: Tartakovsky
- first_name: Terrence J.
full_name: Sejnowski, Terrence J.
last_name: Sejnowski
citation:
ama: Regner BM, Vučinić D, Domnisoru C, et al. Anomalous diffusion of single particles
in cytoplasm. Biophysical Journal. 2013;104(8):1652-1660. doi:10.1016/j.bpj.2013.01.049
apa: Regner, B. M., Vučinić, D., Domnisoru, C., Bartol, T. M., Hetzer, M., Tartakovsky,
D. M., & Sejnowski, T. J. (2013). Anomalous diffusion of single particles
in cytoplasm. Biophysical Journal. Elsevier. https://doi.org/10.1016/j.bpj.2013.01.049
chicago: Regner, Benjamin M., Dejan Vučinić, Cristina Domnisoru, Thomas M. Bartol,
Martin Hetzer, Daniel M. Tartakovsky, and Terrence J. Sejnowski. “Anomalous Diffusion
of Single Particles in Cytoplasm.” Biophysical Journal. Elsevier, 2013.
https://doi.org/10.1016/j.bpj.2013.01.049.
ieee: B. M. Regner et al., “Anomalous diffusion of single particles in cytoplasm,”
Biophysical Journal, vol. 104, no. 8. Elsevier, pp. 1652–1660, 2013.
ista: Regner BM, Vučinić D, Domnisoru C, Bartol TM, Hetzer M, Tartakovsky DM, Sejnowski
TJ. 2013. Anomalous diffusion of single particles in cytoplasm. Biophysical Journal.
104(8), 1652–1660.
mla: Regner, Benjamin M., et al. “Anomalous Diffusion of Single Particles in Cytoplasm.”
Biophysical Journal, vol. 104, no. 8, Elsevier, 2013, pp. 1652–60, doi:10.1016/j.bpj.2013.01.049.
short: B.M. Regner, D. Vučinić, C. Domnisoru, T.M. Bartol, M. Hetzer, D.M. Tartakovsky,
T.J. Sejnowski, Biophysical Journal 104 (2013) 1652–1660.
date_created: 2022-04-07T07:51:26Z
date_published: 2013-04-16T00:00:00Z
date_updated: 2022-07-18T08:51:01Z
day: '16'
doi: 10.1016/j.bpj.2013.01.049
extern: '1'
external_id:
pmid:
- '23601312'
intvolume: ' 104'
issue: '8'
keyword:
- Biophysics
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.bpj.2013.01.049
month: '04'
oa: 1
oa_version: Published Version
page: 1652-1660
pmid: 1
publication: Biophysical Journal
publication_identifier:
issn:
- 0006-3495
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Anomalous diffusion of single particles in cytoplasm
type: journal_article
user_id: 72615eeb-f1f3-11ec-aa25-d4573ddc34fd
volume: 104
year: '2013'
...