---
_id: '10896'
abstract:
- lang: eng
text: Under physiological conditions the brain, via the purine salvage pathway,
reuses the preformed purine bases hypoxanthine, derived from ATP degradation,
and adenine (Ade), derived from polyamine synthesis, to restore its ATP pool.
However, the massive degradation of ATP during ischemia, although providing valuable
neuroprotective adenosine, results in the accumulation and loss of diffusible
purine metabolites and thereby leads to a protracted reduction in the post-ischemic
ATP pool size. In vivo, this may both limit the ability to deploy ATP-dependent
reparative mechanisms and reduce the subsequent availability of adenosine, whilst
in brain slices results in tissue with substantially lower levels of ATP than
in vivo. In the present review, we describe the mechanisms by which brain tissue
replenishes its ATP, how this can be improved with the clinically tolerated chemicals
D-ribose and adenine, and the functional, and potential therapeutic, implications
of doing so.
acknowledgement: We are grateful to Research into Ageing/Ageing UK and The Dunhill
Trust for funding SzN’s graduate studies, and to Prof Nicholas Dale for his valuable
input.
article_processing_charge: No
author:
- first_name: Stephanie
full_name: zur Nedden, Stephanie
id: 3C77F464-F248-11E8-B48F-1D18A9856A87
last_name: zur Nedden
- first_name: Alexander S.
full_name: Doney, Alexander S.
last_name: Doney
- first_name: Bruno G.
full_name: Frenguelli, Bruno G.
last_name: Frenguelli
citation:
ama: 'zur Nedden S, Doney AS, Frenguelli BG. The double-edged sword: Gaining Adenosine
at the expense of ATP. How to balance the books. In: Masino S, Boison D, eds.
Adenosine. 1st ed. New York: Springer; 2012:109-129. doi:10.1007/978-1-4614-3903-5_6'
apa: 'zur Nedden, S., Doney, A. S., & Frenguelli, B. G. (2012). The double-edged
sword: Gaining Adenosine at the expense of ATP. How to balance the books. In S.
Masino & D. Boison (Eds.), Adenosine (1st ed., pp. 109–129). New York:
Springer. https://doi.org/10.1007/978-1-4614-3903-5_6'
chicago: 'Nedden, Stephanie zur, Alexander S. Doney, and Bruno G. Frenguelli. “The
Double-Edged Sword: Gaining Adenosine at the Expense of ATP. How to Balance the
Books.” In Adenosine, edited by Susan Masino and Detlev Boison, 1st ed.,
109–29. New York: Springer, 2012. https://doi.org/10.1007/978-1-4614-3903-5_6.'
ieee: 'S. zur Nedden, A. S. Doney, and B. G. Frenguelli, “The double-edged sword:
Gaining Adenosine at the expense of ATP. How to balance the books,” in Adenosine,
1st ed., S. Masino and D. Boison, Eds. New York: Springer, 2012, pp. 109–129.'
ista: 'zur Nedden S, Doney AS, Frenguelli BG. 2012.The double-edged sword: Gaining
Adenosine at the expense of ATP. How to balance the books. In: Adenosine. , 109–129.'
mla: 'zur Nedden, Stephanie, et al. “The Double-Edged Sword: Gaining Adenosine at
the Expense of ATP. How to Balance the Books.” Adenosine, edited by Susan
Masino and Detlev Boison, 1st ed., Springer, 2012, pp. 109–29, doi:10.1007/978-1-4614-3903-5_6.'
short: S. zur Nedden, A.S. Doney, B.G. Frenguelli, in:, S. Masino, D. Boison (Eds.),
Adenosine, 1st ed., Springer, New York, 2012, pp. 109–129.
date_created: 2022-03-21T07:16:12Z
date_published: 2012-07-23T00:00:00Z
date_updated: 2022-06-21T11:51:58Z
day: '23'
department:
- _id: HaJa
doi: 10.1007/978-1-4614-3903-5_6
edition: '1'
editor:
- first_name: Susan
full_name: Masino, Susan
last_name: Masino
- first_name: Detlev
full_name: Boison, Detlev
last_name: Boison
language:
- iso: eng
month: '07'
oa_version: None
page: 109-129
place: New York
publication: Adenosine
publication_identifier:
eisbn:
- '9781461439035'
isbn:
- '9781461439028'
publication_status: published
publisher: Springer
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'The double-edged sword: Gaining Adenosine at the expense of ATP. How to balance
the books'
type: book_chapter
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2012'
...