--- res: bibo_abstract: - The Golgi apparatus regulates the process of modification and subcellular localization of macromolecules, including proteins and lipids. Aberrant protein sorting caused by defects in the Golgi leads to various diseases in mammals. However, the role of the Golgi apparatus in organismal longevity remained largely unknown. By employing a quantitative proteomic approach, we demonstrated that MON-2, an evolutionarily conserved Arf-GEF protein implicated in Golgi-to-endosome trafficking, promotes longevity via upregulating macroautophagy/autophagy in C. elegans. Our data using cultured mammalian cells indicate that MON2 translocates from the Golgi to the endosome under starvation conditions, subsequently increasing autophagic flux by binding LGG-1/GABARAPL2. Thus, Golgi-to-endosome trafficking appears to be an evolutionarily conserved process for the upregulation of autophagy, which contributes to organismal longevity.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Murat foaf_name: Artan, Murat foaf_surname: Artan foaf_workInfoHomepage: http://www.librecat.org/personId=C407B586-6052-11E9-B3AE-7006E6697425 orcid: 0000-0001-8945-6992 - foaf_Person: foaf_givenName: Jooyeon foaf_name: Sohn, Jooyeon foaf_surname: Sohn - foaf_Person: foaf_givenName: Cheolju foaf_name: Lee, Cheolju foaf_surname: Lee - foaf_Person: foaf_givenName: Seung Yeol foaf_name: Park, Seung Yeol foaf_surname: Park - foaf_Person: foaf_givenName: Seung Jae V. foaf_name: Lee, Seung Jae V. foaf_surname: Lee bibo_doi: 10.1080/15548627.2022.2039523 bibo_issue: '5' bibo_volume: 18 dct_date: 2022^xs_gYear dct_identifier: - UT:000758859600001 dct_isPartOf: - http://id.crossref.org/issn/1554-8627 - http://id.crossref.org/issn/1554-8635 dct_language: eng dct_publisher: Taylor & Francis@ dct_title: MON-2, a Golgi protein, promotes longevity by upregulating autophagy through mediating inter-organelle communications@ fabio_hasPubmedId: '35188063' ...