--- res: bibo_abstract: - Several promising strategies based on combining or cycling different antibiotics have been proposed to increase efficacy and counteract resistance evolution, but we still lack a deep understanding of the physiological responses and genetic mechanisms that underlie antibiotic interactions and the clinical applicability of these strategies. In antibiotic-exposed bacteria, the combined effects of physiological stress responses and emerging resistance mutations (occurring at different time scales) generate complex and often unpredictable dynamics. In this Review, we present our current understanding of bacterial cell physiology and genetics of responses to antibiotics. We emphasize recently discovered mechanisms of synergistic and antagonistic drug interactions, hysteresis in temporal interactions between antibiotics that arise from microbial physiology and interactions between antibiotics and resistance mutations that can cause collateral sensitivity or cross-resistance. We discuss possible connections between the different phenomena and indicate relevant research directions. A better and more unified understanding of drug and genetic interactions is likely to advance antibiotic therapy.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Roderich foaf_name: Römhild, Roderich foaf_surname: Römhild foaf_workInfoHomepage: http://www.librecat.org/personId=68E56E44-62B0-11EA-B963-444F3DDC885E orcid: 0000-0001-9480-5261 - foaf_Person: foaf_givenName: Mark Tobias foaf_name: Bollenbach, Mark Tobias foaf_surname: Bollenbach foaf_workInfoHomepage: http://www.librecat.org/personId=3E6DB97A-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0003-4398-476X - foaf_Person: foaf_givenName: Dan I. foaf_name: Andersson, Dan I. foaf_surname: Andersson bibo_doi: 10.1038/s41579-022-00700-5 bibo_volume: 20 dct_date: 2022^xs_gYear dct_identifier: - UT:000763891900001 dct_isPartOf: - http://id.crossref.org/issn/1740-1526 - http://id.crossref.org/issn/1740-1534 dct_language: eng dct_publisher: Springer Nature@ dct_subject: - General Immunology and Microbiology - Microbiology - Infectious Diseases dct_title: The physiology and genetics of bacterial responses to antibiotic combinations@ fabio_hasPubmedId: '35241807' ...