--- res: bibo_abstract: - In dense biological tissues, cell types performing different roles remain segregated by maintaining sharp interfaces. To better understand the mechanisms for such sharp compartmentalization, we study the effect of an imposed heterotypic tension at the interface between two distinct cell types in a fully 3D Voronoi model for confluent tissues. We find that cells rapidly sort and self-organize to generate a tissue-scale interface between cell types, and cells adjacent to this interface exhibit signature geometric features including nematic-like ordering, bimodal facet areas, and registration, or alignment, of cell centers on either side of the two-tissue interface. The magnitude of these features scales directly with the magnitude of the imposed tension, suggesting that biologists can estimate the magnitude of tissue surface tension between two tissue types simply by segmenting a 3D tissue. To uncover the underlying physical mechanisms driving these geometric features, we develop two minimal, ordered models using two different underlying lattices that identify an energetic competition between bulk cell shapes and tissue interface area. When the interface area dominates, changes to neighbor topology are costly and occur less frequently, which generates the observed geometric features.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Preeti foaf_name: Sahu, Preeti foaf_surname: Sahu foaf_workInfoHomepage: http://www.librecat.org/personId=55BA52EE-A185-11EA-88FD-18AD3DDC885E - foaf_Person: foaf_givenName: J. M. foaf_name: Schwarz, J. M. foaf_surname: Schwarz - foaf_Person: foaf_givenName: M. Lisa foaf_name: Manning, M. Lisa foaf_surname: Manning bibo_doi: 10.1088/1367-2630/ac23f1 bibo_issue: '9' bibo_volume: 23 dct_date: 2021^xs_gYear dct_identifier: - UT:000702042400001 dct_isPartOf: - http://id.crossref.org/issn/13672630 dct_language: eng dct_publisher: IOP Publishing@ dct_title: Geometric signatures of tissue surface tension in a three-dimensional model of confluent tissue@ ...