--- res: bibo_abstract: - Hippocampal and neocortical neural activity is modulated by the position of the individual in space. While hippocampal neurons provide the basis for a spatial map, prefrontal cortical neurons generalize over environmental features. Whether these generalized representations result from a bidirectional interaction with, or are mainly derived from hippocampal spatial representations is not known. By examining simultaneously recorded hippocampal and medial prefrontal neurons, we observed that prefrontal spatial representations show a delayed coherence with hippocampal ones. We also identified subpopulations of cells in the hippocampus and medial prefrontal cortex that formed functional cross-area couplings; these resembled the optimal connections predicted by a probabilistic model of spatial information transfer and generalization. Moreover, cross-area couplings were strongest and had the shortest delay preceding spatial decision-making. Our results suggest that generalized spatial coding in the medial prefrontal cortex is inherited from spatial representations in the hippocampus, and that the routing of information can change dynamically with behavioral demands.@eng bibo_authorlist: - foaf_Person: foaf_givenName: Michele foaf_name: Nardin, Michele foaf_surname: Nardin foaf_workInfoHomepage: http://www.librecat.org/personId=30BD0376-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0001-8849-6570 - foaf_Person: foaf_givenName: Karola foaf_name: Käfer, Karola foaf_surname: Käfer foaf_workInfoHomepage: http://www.librecat.org/personId=2DAA49AA-F248-11E8-B48F-1D18A9856A87 - foaf_Person: foaf_givenName: Jozsef L foaf_name: Csicsvari, Jozsef L foaf_surname: Csicsvari foaf_workInfoHomepage: http://www.librecat.org/personId=3FA14672-F248-11E8-B48F-1D18A9856A87 orcid: 0000-0002-5193-4036 bibo_doi: 10.1101/2021.09.30.462269 dct_date: 2021^xs_gYear dct_language: eng dct_publisher: Cold Spring Harbor Laboratory@ dct_title: The generalized spatial representation in the prefrontal cortex is inherited from the hippocampus@ ...