Revealing the mechanisms underlying drug interactions

Project Period: 2015-01-01 – 2017-09-30
Externally Funded
Principal Investigator
Tobias Bollenbach
Department(s)
Bollenbach Group
Grant Number
P27201-B22
Funding Organisation
FWF

13 Publications

2017 | Journal Article | IST-REx-ID: 713 | OA
Mapping the mouse Allelome reveals tissue specific regulation of allelic expression
D. Andergassen, C. Dotter, D. Wenzel, V. Sigl, P. Bammer, M. Muckenhuber, D. Mayer, T. Kulinski, H. Theussl, J. Penninger, C. Bock, D. Barlow, F. Pauler, Q. Hudson, ELife 6 (2017).
View | Files available | DOI
 
2020 | Preprint | IST-REx-ID: 7673 | OA
A minimal biophysical model of combined antibiotic action
B. Kavcic, G. Tkačik, T. Bollenbach, BioRxiv (2020).
View | Download Preprint (ext.)
 
2019 | Journal Article | IST-REx-ID: 6046 | OA
Temporal order and precision of complex stress responses in individual bacteria
K. Mitosch, G. Rieckh, M.T. Bollenbach, Molecular Systems Biology 15 (2019).
View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 
2017 | Journal Article | IST-REx-ID: 666 | OA
Noisy response to antibiotic stress predicts subsequent single cell survival in an acidic environment
K. Mitosch, G. Rieckh, M.T. Bollenbach, Cell Systems 4 (2017) 393–403.
View | Files available | DOI
 
2017 | Journal Article | IST-REx-ID: 679 | OA
The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection
F. Ebner, V. Sedlyarov, S. Tasciyan, M. Ivin, F. Kratochvill, N. Gratz, L. Kenner, A. Villunger, M.K. Sixt, P. Kovarik, The Journal of Clinical Investigation 127 (2017) 2051–2065.
View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 
2019 | Journal Article | IST-REx-ID: 7026 | OA
Emergent gene expression responses to drug combinations predict higher-order drug interactions
M. Lukacisin, M.T. Bollenbach, Cell Systems 9 (2019) 423-433.e1-e3.
View | Files available | DOI
 
2015 | Journal Article | IST-REx-ID: 1619 | OA
Quantifying the determinants of evolutionary dynamics leading to drug resistance
G. Chevereau, M. Lukacisinova, T. Batur, A. Guvenek, D. Ayhan, E. Toprak, M.T. Bollenbach, PLoS Biology 13 (2015).
View | Files available | DOI
 
2015 | Journal Article | IST-REx-ID: 1810 | OA
Antimicrobial interactions: Mechanisms and implications for drug discovery and resistance evolution
M.T. Bollenbach, Current Opinion in Microbiology 27 (2015) 1–9.
View | Files available | DOI
 
2015 | Journal Article | IST-REx-ID: 1823 | OA
Systematic discovery of drug interaction mechanisms
G. Chevereau, M.T. Bollenbach, Molecular Systems Biology 11 (2015).
View | Files available | DOI
 
2020 | Journal Article | IST-REx-ID: 8037 | OA
Highly parallel lab evolution reveals that epistasis can curb the evolution of antibiotic resistance
M. Lukacisinova, B. Fernando, M.T. Bollenbach, Nature Communications 11 (2020).
View | Files available | DOI
 
2017 | Journal Article | IST-REx-ID: 822 | OA
Interaction networks, ecological stability, and collective antibiotic tolerance in polymicrobial infections
M. De Vos, M.P. Zagórski, A. Mcnally, M.T. Bollenbach, PNAS 114 (2017) 10666–10671.
View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 
2020 | Journal Article | IST-REx-ID: 8250 | OA
Mechanisms of drug interactions between translation-inhibiting antibiotics
B. Kavcic, G. Tkačik, M.T. Bollenbach, Nature Communications 11 (2020).
View | Files available | DOI
 
2017 | Journal Article | IST-REx-ID: 1027 | OA
Toward a quantitative understanding of antibiotic resistance evolution
M. Lukacisinova, M.T. Bollenbach, Current Opinion in Biotechnology 46 (2017) 90–97.
View | Files available | DOI