Cytoskeletal force generation and force transduction of migrating leukocytes

Project Period: 2012-04-01 – 2017-03-31
Externally Funded
Acronym
LeukocyteForces
Principal Investigator
Michael K Sixt
Department(s)
Sixt Group
Grant Number
281556
Funding Organisation
FP7_ERC

15 Publications

2016 | Journal Article | IST-REx-ID: 1597   OA
Quantitative analysis of dendritic cell haptotaxis
J. Schwarz, M.K. Sixt, Methods in Enzymology 570 (2016) 567–581.
View | DOI | Download (ext.) | PubMed | Europe PMC
 
2016 | Journal Article | IST-REx-ID: 1321
Diversified actin protrusions promote environmental exploration but are dispensable for locomotion of leukocytes
A.F. Leithner, A. Eichner, J. Müller, A. Reversat, M. Brown, J. Schwarz, J. Merrin, D. De Gorter, F. Schur, J. Bayerl, I. De Vries, S. Wieser, R. Hauschild, F. Lai, M. Moser, D. Kerjaschki, K. Rottner, V. Small, T. Stradal, M.K. Sixt, Nature Cell Biology 18 (2016) 1253–1259.
View | Files available | DOI
 
2016 | Journal Article | IST-REx-ID: 1154   OA
A microfluidic device for measuring cell migration towards substrate bound and soluble chemokine gradients
J. Schwarz, V. Bierbaum, J. Merrin, T. Frank, R. Hauschild, M.T. Bollenbach, S. Tay, M.K. Sixt, M. Mehling, Scientific Reports 6 (2016).
View | Files available | DOI
 
2015 | Journal Article | IST-REx-ID: 1553
Actin flows mediate a universal coupling between cell speed and cell persistence
P. Maiuri, J. Rupprecht, S. Wieser, V. Ruprecht, O. Bénichou, N. Carpi, M. Coppey, S. De Beco, N. Gov, C.-P.J. Heisenberg, C. Lage Crespo, F. Lautenschlaeger, M. Le Berre, A. Lennon Duménil, M. Raab, H. Thiam, M. Piel, M.K. Sixt, R. Voituriez, Cell 161 (2015) 374–386.
View | DOI
 
2018 | Journal Article | IST-REx-ID: 275   OA
Lymphatic exosomes promote dendritic cell migration along guidance cues
M. Brown, L. Johnson, D. Leone, P. Májek, K. Vaahtomeri, D. Senfter, N. Bukosza, H. Schachner, G. Asfour, B. Langer, R. Hauschild, K. Parapatics, Y. Hong, K. Bennett, R. Kain, M. Detmar, M.K. Sixt, D. Jackson, D. Kerjaschki, Journal of Cell Biology 217 (2018) 2205–2221.
View | Files available | DOI | PubMed | Europe PMC
 
2016 | Journal Article | IST-REx-ID: 1599
Polysialylation controls dendritic cell trafficking by regulating chemokine recognition
E. Kiermaier, C. Moussion, C. Veldkamp, R. Gerardy  Schahn, I. De Vries, L. Williams, G. Chaffee, A. Phillips, F. Freiberger, R. Imre, D. Taleski, R. Payne, A. Braun, R. Förster, K. Mechtler, M. Mühlenhoff, B. Volkman, M.K. Sixt, Science 351 (2016) 186–190.
View | DOI | PubMed | Europe PMC
 
2019 | Journal Article | IST-REx-ID: 6328
Nuclear positioning facilitates amoeboid migration along the path of least resistance
J. Renkawitz, A. Kopf, J.A. Stopp, I. de Vries, M.K. Driscoll, J. Merrin, R. Hauschild, E.S. Welf, G. Danuser, R. Fiolka, M.K. Sixt, Nature (2019).
View | Files available | DOI
 
2017 | Journal Article | IST-REx-ID: 672   OA
Locally triggered release of the chemokine CCL21 promotes dendritic cell transmigration across lymphatic endothelia
K. Vaahtomeri, M. Brown, R. Hauschild, I. De Vries, A.F. Leithner, M. Mehling, W. Kaufmann, M.K. Sixt, Cell Reports 19 (2017) 902–909.
View | Files available | DOI
 
2015 | Journal Article | IST-REx-ID: 1618   OA
Solution structure of CCL19 and identification of overlapping CCR7 and PSGL-1 binding sites
C. Veldkamp, E. Kiermaier, S. Gabel Eissens, M. Gillitzer, D. Lippner, F. Disilvio, C. Mueller, P. Wantuch, G. Chaffee, M. Famiglietti, D. Zgoba, A. Bailey, Y. Bah, S. Engebretson, D. Graupner, E. Lackner, V. Larosa, T. Medeiros, M. Olson, A. Phillips, H. Pyles, A. Richard, S. Schoeller, B. Touzeau, L. Williams, M.K. Sixt, F. Peterson, Biochemistry 54 (2015) 4163–4166.
View | DOI | Download (ext.) | PubMed | Europe PMC
 
2015 | Journal Article | IST-REx-ID: 1687   OA
Navigating in tissue mazes: Chemoattractant interpretation in complex environments
M. Sarris, M.K. Sixt, Current Opinion in Cell Biology 36 (2015) 93–102.
View | Files available | DOI
 
2017 | Journal Article | IST-REx-ID: 727
Load adaptation of lamellipodial actin networks
J. Mueller, G. Szep, M. Nemethova, I. De Vries, A. Lieber, C. Winkler, K. Kruse, J. Small, C. Schmeiser, K. Keren, R. Hauschild, M.K. Sixt, Cell 171 (2017) 188–200.
View | DOI
 
2016 | Journal Article | IST-REx-ID: 1285
Focal adhesion-independent cell migration
E. Paluch, I. Aspalter, M.K. Sixt, Annual Review of Cell and Developmental Biology 32 (2016) 469–490.
View | DOI
 
2018 | Journal Article | IST-REx-ID: 15   OA
Chemokines and integrins independently tune actin flow and substrate friction during intranodal migration of T cells
M. Hons, A. Kopf, R. Hauschild, A.F. Leithner, F.R. Gärtner, J. Abe, J. Renkawitz, J. Stein, M.K. Sixt, Nature Immunology 19 (2018) 606–616.
View | DOI | Download (ext.) | PubMed | Europe PMC
 
2013 | Journal Article | IST-REx-ID: 2839
Interstitial dendritic cell guidance by haptotactic chemokine gradients
M. Weber, R. Hauschild, J. Schwarz, C. Moussion, I. De Vries, D. Legler, S. Luther, M.T. Bollenbach, M.K. Sixt, Science 339 (2013) 328–332.
View | DOI
 
2018 | Journal Article | IST-REx-ID: 402   OA
Lymph node blood vessels provide exit routes for metastatic tumor cell dissemination in mice
M. Brown, F.P. Assen, A.F. Leithner, J. Abe, H. Schachner, G. Asfour, Z. Bagó Horváth, J. Stein, P. Uhrin, M.K. Sixt, D. Kerjaschki, Science 359 (2018) 1408–1411.
View | DOI | Download (ext.) | PubMed | Europe PMC