In situ real-time imaging of neurotransmitter signaling using designer optical sensors
Project Period: 2012-08-01 – 2016-01-31
Externally Funded
Principal Investigator
Harald L Janovjak
Department(s)
Janovjak Group
Grant Number
RGY0084/2012
Funding Organisation
HFSP
8 Publications
2013 | Journal Article | IST-REx-ID: 2857 |

Optical control of ligand-gated ion channels
S. Szobota, C. Mckenzie, H.L. Janovjak, Methods in Molecular Biology 998 (2013) 417–435.
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S. Szobota, C. Mckenzie, H.L. Janovjak, Methods in Molecular Biology 998 (2013) 417–435.
2015 | Journal Article | IST-REx-ID: 1611 |

Construction of a robust and sensitive arginine biosensor through ancestral protein reconstruction
J. Whitfield, W. Zhang, M. Herde, B. Clifton, J. Radziejewski, H.L. Janovjak, C. Henneberger, C. Jackson, Protein Science 24 (2015) 1412–1422.
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| Download Submitted Version (ext.)
| PubMed | Europe PMC
J. Whitfield, W. Zhang, M. Herde, B. Clifton, J. Radziejewski, H.L. Janovjak, C. Henneberger, C. Jackson, Protein Science 24 (2015) 1412–1422.
2015 | Journal Article | IST-REx-ID: 1678 |

Light-assisted small-molecule screening against protein kinases
Á. Inglés Prieto, E. Gschaider-Reichhart, M. Muellner, M. Nowak, S. Nijman, M. Grusch, H.L. Janovjak, Nature Chemical Biology 11 (2015) 952–954.
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Á. Inglés Prieto, E. Gschaider-Reichhart, M. Muellner, M. Nowak, S. Nijman, M. Grusch, H.L. Janovjak, Nature Chemical Biology 11 (2015) 952–954.
2015 | Journal Article | IST-REx-ID: 1867
Quantification of riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in mammalian model cells by CE with LED-induced fluorescence detection
J. Hühner, Á. Inglés Prieto, C. Neusüß, M. Lämmerhofer, H.L. Janovjak, Electrophoresis 36 (2015) 518–525.
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J. Hühner, Á. Inglés Prieto, C. Neusüß, M. Lämmerhofer, H.L. Janovjak, Electrophoresis 36 (2015) 518–525.
2018 | Journal Article | IST-REx-ID: 137 |

Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS
W. Zhang, M. Herde, J. Mitchell, J. Whitfield, A. Wulff, V. Vongsouthi, I. Sanchez-Romero, P. Gulakova, D. Minge, B. Breithausen, S. Schoch, H.L. Janovjak, C. Jackson, C. Henneberger, Nature Chemical Biology 14 (2018) 861–869.
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| Download Submitted Version (ext.)
| PubMed | Europe PMC
W. Zhang, M. Herde, J. Mitchell, J. Whitfield, A. Wulff, V. Vongsouthi, I. Sanchez-Romero, P. Gulakova, D. Minge, B. Breithausen, S. Schoch, H.L. Janovjak, C. Jackson, C. Henneberger, Nature Chemical Biology 14 (2018) 861–869.
2016 | Journal Article | IST-REx-ID: 1440
Light at the end of the protein: Crystal structure of a C-terminal light-sensing domain
H.L. Janovjak, Structure 24 (2016) 213–215.
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| DOI
H.L. Janovjak, Structure 24 (2016) 213–215.
2017 | Book Chapter | IST-REx-ID: 957
Ancestral protein reconstruction and circular permutation for improving the stability and dynamic range of FRET sensors
B. Clifton, J. Whitfield, I. Sanchez-Romero, M. Herde, C. Henneberger, H.L. Janovjak, C. Jackson, in:, V. Stein (Ed.), Synthetic Protein Switches, Springer, 2017, pp. 71–87.
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B. Clifton, J. Whitfield, I. Sanchez-Romero, M. Herde, C. Henneberger, H.L. Janovjak, C. Jackson, in:, V. Stein (Ed.), Synthetic Protein Switches, Springer, 2017, pp. 71–87.
2017 | Journal Article | IST-REx-ID: 1026
Optogenetic methods in drug screening: Technologies and applications
V. Agus, H.L. Janovjak, Current Opinion in Biotechnology 48 (2017) 8–14.
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V. Agus, H.L. Janovjak, Current Opinion in Biotechnology 48 (2017) 8–14.