Biophysics of information processing in gene regulation

Project Period: 2016-01-01 – 2018-12-31
Externally Funded
Principal Investigator
Gašper Tkačik
Department(s)
Tkacik Group
Grant Number
P28844-B27
Funding Organisation
FWF

13 Publications

2016 | Journal Article | IST-REx-ID: 1358
Intrinsic limits to gene regulation by global crosstalk
T. Friedlander, R. Prizak, C.C. Guet, N.H. Barton, G. Tkacik, Nature Communications 7 (2016) 12307.
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2017 | Journal Article | IST-REx-ID: 943   OA
Decoding of position in the developing neural tube from antiparallel morphogen gradients
M.P. Zagórski, Y. Tabata, N. Brandenberg, M. Lutolf, G. Tkacik, T. Bollenbach, J. Briscoe, A. Kicheva, Science 356 (2017) 1379–1383.
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2017 | Journal Article | IST-REx-ID: 955   OA
Evolution of new regulatory functions on biophysically realistic fitness landscapes
T. Friedlander, R. Prizak, N.H. Barton, G. Tkacik, Nature Communications 8 (2017) 216.
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2019 | Journal Article | IST-REx-ID: 5945
Optimal decoding of cellular identities in a genetic network
M.D. Petkova, G. Tkacik, W. Bialek, E.F. Wieschaus, T. Gregor, Cell 176 (2019) 844–855.e15.
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2017 | Journal Article | IST-REx-ID: 665
Biased partitioning of the multidrug efflux pump AcrAB TolC underlies long lived phenotypic heterogeneity
T. Bergmiller, A.M. Andersson, K. Tomasek, E. Balleza, D. Kiviet, R. Hauschild, G. Tkacik, C.C. Guet, Science 356 (2017) 311–315.
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2019 | Journal Article | IST-REx-ID: 6900   OA
Estimating information in time-varying signals
S.A. Cepeda Humerez, J. Ruess, G. Tkačik, PLoS Computational Biology 15 (2019) e1007290.
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2016 | Journal Article | IST-REx-ID: 1270   OA View | Files available | DOI
 
2018 | Research Data | IST-REx-ID: 5587   OA
Supporting materials "STATISTICAL MECHANICS FOR METABOLIC NETWORKS IN STEADY-STATE GROWTH"
D. De Martino, G. Tkacik, Supporting Materials “STATISTICAL MECHANICS FOR METABOLIC NETWORKS IN STEADY-STATE GROWTH,” IST Austria, 2018.
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2017 | Journal Article | IST-REx-ID: 613   OA
Shaping bacterial population behavior through computer interfaced control of individual cells
R.P. Chait, J. Ruess, T. Bergmiller, G. Tkacik, C.C. Guet, Nature Communications 8 (2017).
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2016 | Journal Article | IST-REx-ID: 1242   OA
Extending the dynamic range of transcription factor action by translational regulation
T.R. Sokolowski, A. Walczak, W. Bialek, G. Tkacik, Physical Review E Statistical Nonlinear and Soft Matter Physics 93 (2016).
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2018 | Journal Article | IST-REx-ID: 161
Statistical mechanics for metabolic networks during steady state growth
D. De Martino, A.A. Mc, T. Bergmiller, C.C. Guet, G. Tkacik, Nature Communications 9 (2018) 2988.
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2018 | Journal Article | IST-REx-ID: 281
Distributed and dynamic intracellular organization of extracellular information
A. Granados, J. Pietsch, S.A. Cepeda Humerez, I. Farquhar, G. Tkacik, P. Swain, PNAS 115 (2018) 6088–6093.
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2019 | Thesis | IST-REx-ID: 6071
Coevolution of transcription factors and their binding sites in sequence space
R. Prizak, Coevolution of Transcription Factors and Their Binding Sites in Sequence Space, IST Austria, 2019.
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