Biophysics of information processing in gene regulation

Project Period: 2016-01-01 – 2018-12-31
Externally Funded
Principal Investigator
Gašper Tkačik
Department(s)
Tkacik Group
Grant Number
P28844-B27
Funding Organisation
FWF

15 Publications

2019 | Preprint | IST-REx-ID: 7552 | OA
Action at a distance in transcriptional regulation
W. Bialek, T. Gregor, G. Tkačik, ArXiv:1912.08579 (n.d.).
View | Download Preprint (ext.) | arXiv
 
2020 | Preprint | IST-REx-ID: 7673 | OA
A minimal biophysical model of combined antibiotic action
B. Kavcic, G. Tkačik, T. Bollenbach, BioRxiv (2020).
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2016 | Journal Article | IST-REx-ID: 1358 | OA
Intrinsic limits to gene regulation by global crosstalk
T. Friedlander, R. Prizak, C.C. Guet, N.H. Barton, G. Tkačik, Nature Communications 7 (2016).
View | Files available | DOI
 
2018 | Journal Article | IST-REx-ID: 161 | OA
Statistical mechanics for metabolic networks during steady state growth
D. De Martino, A.A. Mc, T. Bergmiller, C.C. Guet, G. Tkačik, Nature Communications 9 (2018).
View | Files available | DOI
 
2018 | Research Data | IST-REx-ID: 5587 | OA
Supporting materials "STATISTICAL MECHANICS FOR METABOLIC NETWORKS IN STEADY-STATE GROWTH"
D. De Martino, G. Tkačik, Supporting Materials “STATISTICAL MECHANICS FOR METABOLIC NETWORKS IN STEADY-STATE GROWTH,” IST Austria, 2018.
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2018 | Journal Article | IST-REx-ID: 281 | OA
Distributed and dynamic intracellular organization of extracellular information
A. Granados, J. Pietsch, S.A. Cepeda Humerez, I. Farquhar, G. Tkacik, P. Swain, PNAS 115 (2018) 6088–6093.
View | Files available | DOI | Download Preprint (ext.) | PubMed | Europe PMC
 
2016 | Journal Article | IST-REx-ID: 1242 | OA
Extending the dynamic range of transcription factor action by translational regulation
T.R. Sokolowski, A. Walczak, W. Bialek, G. Tkacik, Physical Review E Statistical Nonlinear and Soft Matter Physics 93 (2016).
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2016 | Journal Article | IST-REx-ID: 1270 | OA View | Files available | DOI
 
2019 | Journal Article | IST-REx-ID: 5945
Optimal decoding of cellular identities in a genetic network
M.D. Petkova, G. Tkačik, W. Bialek, E.F. Wieschaus, T. Gregor, Cell 176 (2019) 844–855.e15.
View | Files available | DOI
 
2017 | Journal Article | IST-REx-ID: 613 | OA
Shaping bacterial population behavior through computer interfaced control of individual cells
R.P. Chait, J. Ruess, T. Bergmiller, G. Tkačik, C.C. Guet, Nature Communications 8 (2017).
View | Files available | DOI
 
2017 | Journal Article | IST-REx-ID: 665
Biased partitioning of the multidrug efflux pump AcrAB TolC underlies long lived phenotypic heterogeneity
T. Bergmiller, A.M. Andersson, K. Tomasek, E. Balleza, D. Kiviet, R. Hauschild, G. Tkacik, C.C. Guet, Science 356 (2017) 311–315.
View | Files available | DOI
 
2019 | Journal Article | IST-REx-ID: 6900 | OA
Estimating information in time-varying signals
S.A. Cepeda Humerez, J. Ruess, G. Tkačik, PLoS Computational Biology 15 (2019) e1007290.
View | Files available | DOI | PubMed | Europe PMC
 
2017 | Journal Article | IST-REx-ID: 943 | OA
Decoding of position in the developing neural tube from antiparallel morphogen gradients
M.P. Zagórski, Y. Tabata, N. Brandenberg, M. Lutolf, G. Tkacik, T. Bollenbach, J. Briscoe, A. Kicheva, Science 356 (2017) 1379–1383.
View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 
2017 | Journal Article | IST-REx-ID: 955 | OA
Evolution of new regulatory functions on biophysically realistic fitness landscapes
T. Friedlander, R. Prizak, N.H. Barton, G. Tkačik, Nature Communications 8 (2017).
View | Files available | DOI
 
2019 | Thesis | IST-REx-ID: 6071 | OA
Coevolution of transcription factors and their binding sites in sequence space
R. Prizak, Coevolution of Transcription Factors and Their Binding Sites in Sequence Space, IST Austria, 2019.
View | Files available | DOI