Harald L Janovjak

Janovjak Group

54 Publications

Mark all

[54]
2021 | Journal Article | IST-REx-ID: 10144 | OA
Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in mice
T. Rauschendorfer, S. Gurri, I. Heggli, L. Maddaluno, M. Meyer, Á. Inglés Prieto, H.L. Janovjak, S. Werner, Life Science Alliance 4 (2021).
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
[53]
2021 | Journal Article | IST-REx-ID: 9363 | OA
Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease
Á. Inglés Prieto, N. Furthmann, S.H. Crossman, A.M. Tichy, N. Hoyer, M. Petersen, V. Zheden, J. Bicher, E. Gschaider-Reichhart, A. György, D.E. Siekhaus, P. Soba, K.F. Winklhofer, H.L. Janovjak, PLoS Genetics 17 (2021) e1009479.
[Published Version] View | Files available | DOI | WoS
 
[52]
2020 | Book Chapter | IST-REx-ID: 8173
Design and application of light-regulated receptor tyrosine kinases
S. Kainrath, H.L. Janovjak, in:, D. Niopek (Ed.), Photoswitching Proteins, Springer Nature, 2020, pp. 233–246.
View | DOI
 
[51]
2020 | Journal Article | IST-REx-ID: 8674 | OA
LTP induction boosts glutamate spillover by driving withdrawal of perisynaptic astroglia
Henneberger C, Bard L, Panatier A, Reynolds JP, Kopach O, Medvedev NI, Minge D, Herde MK, Anders S, Kraev I, Heller JP, Rama S, Zheng K, Jensen TP, Sanchez-Romero I, Jackson CJ, Janovjak HL, Ottersen OP, Nagelhus EA, Oliet SHR, Stewart MG, Nägerl UVa, Rusakov DA. 2020. LTP induction boosts glutamate spillover by driving withdrawal of perisynaptic astroglia. Neuron. 108(5), P919–936.E11.
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 
[50]
2019 | Journal Article | IST-REx-ID: 6025 | OA
Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration
D. Capek, M. Smutny, A.M. Tichy, M. Morri, H.L. Janovjak, C.-P.J. Heisenberg, ELife 8 (2019).
[Published Version] View | Files available | DOI | WoS
 
[49]
2019 | Journal Article | IST-REx-ID: 6564 | OA
Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions
A.-M. Tichy, E.J. Gerrard, J.M.D. Legrand, R.M. Hobbs, H.L. Janovjak, Journal of Molecular Biology 431 (2019) 3046–3055.
[Preprint] View | DOI | Download Preprint (ext.) | WoS
 
[48]
2019 | Journal Article | IST-REx-ID: 7406
Isolation of synaptic vesicles from genetically engineered cultured neurons
C. Mckenzie, M. Spanova, A.J. Johnson, S. Kainrath, V. Zheden, H.H. Sitte, H.L. Janovjak, Journal of Neuroscience Methods 312 (2019) 114–121.
View | DOI | WoS | PubMed | Europe PMC
 
[47]
2018 | Journal Article | IST-REx-ID: 137 | OA
Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS
W. Zhang, M. Herde, J. Mitchell, J. Whitfield, A. Wulff, V. Vongsouthi, I. Sanchez-Romero, P. Gulakova, D. Minge, B. Breithausen, S. Schoch, H.L. Janovjak, C. Jackson, C. Henneberger, Nature Chemical Biology 14 (2018) 861–869.
[Submitted Version] View | DOI | Download Submitted Version (ext.) | WoS | PubMed | Europe PMC
 
[46]
2018 | Journal Article | IST-REx-ID: 5984 | OA
Optical functionalization of human class A orphan G-protein-coupled receptors
M. Morri, I. Sanchez-Romero, A.-M. Tichy, S. Kainrath, E.J. Gerrard, P. Hirschfeld, J. Schwarz, H.L. Janovjak, Nature Communications 9 (2018).
[Published Version] View | Files available | DOI | WoS
 
[45]
2017 | Journal Article | IST-REx-ID: 538 | OA
Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen
S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie 129 (2017) 4679–4682.
[Published Version] View | Files available | DOI
 
[44]
2017 | Book Chapter | IST-REx-ID: 957
Ancestral protein reconstruction and circular permutation for improving the stability and dynamic range of FRET sensors
B. Clifton, J. Whitfield, I. Sanchez-Romero, M. Herde, C. Henneberger, H.L. Janovjak, C. Jackson, in:, V. Stein (Ed.), Synthetic Protein Switches, Springer, 2017, pp. 71–87.
View | DOI
 
[43]
2017 | Book Chapter | IST-REx-ID: 958
Method for developing optical sensors using a synthetic dye fluorescent protein FRET pair and computational modeling and assessment
J. Mitchell, W. Zhang, M. Herde, C. Henneberger, H.L. Janovjak, M. O’Mara, C. Jackson, in:, V. Stein (Ed.), Synthetic Protein Switches, Springer, 2017, pp. 89–99.
View | DOI
 
[42]
2017 | Journal Article | IST-REx-ID: 1026
Optogenetic methods in drug screening: Technologies and applications
V. Agus, H.L. Janovjak, Current Opinion in Biotechnology 48 (2017) 8–14.
View | DOI | WoS
 
[41]
2017 | Journal Article | IST-REx-ID: 1028 | OA
Green-light-induced inactivation of receptor signaling using cobalamin-binding domains
S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie - International Edition 56 (2017) 4608–4611.
[Published Version] View | Files available | DOI | WoS
 
[40]
2016 | Journal Article | IST-REx-ID: 1440
Light at the end of the protein: Crystal structure of a C-terminal light-sensing domain
H.L. Janovjak, Structure 24 (2016) 213–215.
View | DOI
 
[39]
2016 | Journal Article | IST-REx-ID: 1101
Rangefinder: A semisynthetic FRET sensor design algorithm
J. Mitchell, J. Whitfield, W. Zhang, C. Henneberger, H.L. Janovjak, M. O’Mara, C. Jackson, ACS SENSORS 1 (2016) 1286–1290.
View | DOI
 
[38]
2016 | Journal Article | IST-REx-ID: 1441 | OA
A phytochrome sensory domain permits receptor activation by red light
E. Gschaider-Reichhart, Á. Inglés Prieto, A.-M. Tichy, C. Mckenzie, H.L. Janovjak, Angewandte Chemie - International Edition 55 (2016) 6339–6342.
[Submitted Version] View | Files available | DOI
 
[37]
2016 | Journal Article | IST-REx-ID: 1100 | OA
Optogenetic control of nodal signaling reveals a temporal pattern of nodal signaling regulating cell fate specification during gastrulation
K. Sako, S. Pradhan, V. Barone, Á. Inglés Prieto, P. Mueller, V. Ruprecht, D. Capek, S. Galande, H.L. Janovjak, C.-P.J. Heisenberg, Cell Reports 16 (2016) 866–877.
[Published Version] View | Files available | DOI
 
[36]
2015 | Book Chapter | IST-REx-ID: 1549 | OA
Flipping the photoswitch: Ion channels under light control
C. Mckenzie, I. Sanchez-Romero, H.L. Janovjak, in:, Novel Chemical Tools to Study Ion Channel Biology, Springer, 2015, pp. 101–117.
[Submitted Version] View | Files available | DOI
 
[35]
2015 | Journal Article | IST-REx-ID: 1611 | OA
Construction of a robust and sensitive arginine biosensor through ancestral protein reconstruction
J. Whitfield, W. Zhang, M. Herde, B. Clifton, J. Radziejewski, H.L. Janovjak, C. Henneberger, C. Jackson, Protein Science 24 (2015) 1412–1422.
[Submitted Version] View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 
[34]
2015 | Journal Article | IST-REx-ID: 1867
Quantification of riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in mammalian model cells by CE with LED-induced fluorescence detection
J. Hühner, Á. Inglés Prieto, C. Neusüß, M. Lämmerhofer, H.L. Janovjak, Electrophoresis 36 (2015) 518–525.
View | DOI
 
[33]
2015 | Journal Article | IST-REx-ID: 1678 | OA
Light-assisted small-molecule screening against protein kinases
Á. Inglés Prieto, E. Gschaider-Reichhart, M. Muellner, M. Nowak, S. Nijman, M. Grusch, H.L. Janovjak, Nature Chemical Biology 11 (2015) 952–954.
[Submitted Version] View | Files available | DOI
 
[32]
2014 | Journal Article | IST-REx-ID: 2032 | OA
The optogenetic promise for oncology: Episode I
Á. Inglés Prieto, E. Gschaider-Reichhart, K. Schelch, H.L. Janovjak, M. Grusch, Molecular and Cellular Oncology 1 (2014).
[Published Version] View | Files available | DOI
 
[31]
2014 | Journal Article | IST-REx-ID: 2084 | OA
Spatio-temporally precise activation of engineered receptor tyrosine kinases by light
M. Grusch, K. Schelch, R. Riedler, E. Gschaider-Reichhart, C. Differ, W. Berger, Á. Inglés Prieto, H.L. Janovjak, EMBO Journal 33 (2014) 1713–1726.
[Submitted Version] View | Files available | DOI | Download Submitted Version (ext.)
 
[30]
2013 | Journal Article | IST-REx-ID: 2857 | OA
Optical control of ligand-gated ion channels
S. Szobota, C. Mckenzie, H.L. Janovjak, Methods in Molecular Biology 998 (2013) 417–435.
[Submitted Version] View | Files available | DOI
 
[29]
2013 | Journal Article | IST-REx-ID: 2856 | OA
Optical control of metabotropic glutamate receptors
J. Levitz, C. Pantoja, B. Gaub, H.L. Janovjak, A. Reiner, A. Hoagland, D. Schoppik, B. Kane, P. Stawski, A. Schier, D. Trauner, E. Isacoff, Nature Neuroscience 16 (2013) 507–516.
[Submitted Version] View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 
[28]
2011 | Journal Article | IST-REx-ID: 3405 | OA
Modern ionotropic glutamate receptor with a K+ selectivity signature sequence
H.L. Janovjak, G. Sandoz, E. Isacoff, Nature Communications 2 (2011) 1–6.
[Submitted Version] View | Files available | DOI
 
[27]
2011 | Book Chapter | IST-REx-ID: 3724
Structure-based design of light-controlled proteins
H.L. Janovjak, E. Isacoff, in:, Photosensitive Molecules for the Control of Biological Function, Springer, 2011, pp. 233–266.
View | DOI
 
[26]
2010 | Journal Article | IST-REx-ID: 3407
A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing
H.L. Janovjak, S. Szobota, C. Wyart, D. Trauner, E. Isacoff, Nature Neuroscience 13 (2010) 1027–1032.
View | DOI
 
[25]
2010 | Book Review | IST-REx-ID: 3406
Pharmacology of ionotropic glutamate receptors: a structural perspective
P. Stawski, H.L. Janovjak, D. Trauner, Bioorganic and Medicinal Chemistry 18 (2010) 7759–7772.
View | DOI
 
[24]
2009 | Journal Article | IST-REx-ID: 3408
Periodic forces trigger a complex mechanical response in ubiquitin
P. Szymczak, H.L. Janovjak, Journal of Molecular Biology 390 (2009) 443–456.
View | DOI
 
[23]
2008 | Book Review | IST-REx-ID: 3410
From valleys to ridges: Exploring the energy landscape of single membrane proteins
H.L. Janovjak, T. Sapra, A. Kedrov, D. Mueller, ChemPhysChem 9 (2008) 954–966.
View | DOI
 
[22]
2008 | Journal Article | IST-REx-ID: 3409
Fully automated single-molecule force spectroscopy for screening applications
J. Struckmeier, R. Wahl, M. Leuschner, J. Nunes, H.L. Janovjak, U. Geisler, G. Hofmann, T. Jähnke, D. Mueller, Nanotechnology 19 (2008).
View | DOI
 
[21]
2008 | Book Chapter | IST-REx-ID: 3726
Single-molecule microscopy and force spectroscopy of membrane proteins
A. Engel, H.L. Janovjak, D. Fotiadis, A. Kedrov, D. Cisneros, D. Mueller, in:, Single Molecules and Nanotechnology, Springer, 2008, pp. 279–311.
View | DOI
 
[20]
2007 | Journal Article | IST-REx-ID: 3411 | OA
Free energy of membrane protein unfolding derived from single-molecule force measurements
J. Preiner, H.L. Janovjak, C. Rankl, H. Knaus, D. Cisneros, A. Kedrov, F. Kienberger, D. Mueller, P. Hinterdorfer, Biophysical Journal 93 (2007) 930–937.
View | DOI | Download (ext.)
 
[19]
2007 | Book Review | IST-REx-ID: 3412
Deciphering molecular interactions of native membrane proteins by single-molecule force spectroscopy
A. Kedrov, H.L. Janovjak, T. Sapra, D. Mueller, Annual Review of Biophysics 36 (2007) 233–260.
View | DOI
 
[18]
2007 | Journal Article | IST-REx-ID: 3727
Digital force-feedback for protein unfolding experiments using atomic force microscopy
C. Bippes, H.L. Janovjak, A. Kedrov, D. Mueller, Nanotechnology 18 (2007).
View | DOI
 
[17]
2007 | Journal Article | IST-REx-ID: 3723
Transmembrane helices have rough energy surfaces
H.L. Janovjak, H. Knaus, D. Mueller, Journal of the American Chemical Society 129 (2007) 246–247.
View | DOI
 
[16]
2006 | Book Chapter | IST-REx-ID: 3404
Atomic force microscopy
H.L. Janovjak, R. Sawhney, M. Stark, D. Mueller, in:, Techniques in Microscopy for Biomedical Applications, World Scientific Publishing, 2006, pp. 213–284.
View
 
[15]
2006 | Journal Article | IST-REx-ID: 3413
Bacteriorhodopsin folds into the membrane against an external force
M. Kessler, K. Gottschalk, H.L. Janovjak, D. Mueller, H. Gaub, Journal of Molecular Biology 357 (2006) 644–654.
View | DOI
 
[14]
2006 | Journal Article | IST-REx-ID: 3414
Observing folding pathways and kinetics of a single sodium-proton antiporter from Escherichia coli
A. Kedrov, H.L. Janovjak, C. Ziegler, W. Kühlbrandt, D. Mueller, Journal of Molecular Biology 355 (2006) 2–8.
View | DOI
 
[13]
2006 | Book Review | IST-REx-ID: 3415
Imaging and detecting molecular interactions of single membrane proteins
H.L. Janovjak, A. Kedrov, D. Cisneros, T. Sapra, J. Struckmeier, D. Mueller, Neurobiology of Aging 27 (2006) 546–561.
View | DOI
 
[12]
2006 | Journal Article | IST-REx-ID: 3729
Direct measurement of single-molecule visco-elasticity in atomic force microscope force-extension experiments
C. Bippes, A. Humphris, M. Stark, D. Mueller, H.L. Janovjak, European Biophysics Journal 35 (2006) 287–292.
View | DOI
 
[11]
2006 | Journal Article | IST-REx-ID: 3728
Pulling single bacteriorhodopsin out of a membrane: Comparison of simulation and experiment
M. Cieplak, S. Filipek, H.L. Janovjak, K. Krzysko, Biochimica et Biophysica Acta (BBA) - Biomembranes 1758 (2006) 537–544.
View | DOI
 
[10]
2006 | Book Chapter | IST-REx-ID: 3722
Rastersondenmikroskopie
H.L. Janovjak, D. Mueller, in:, Bioanalytik, Spektrum Akademischer Verlag, 2006.
View
 
[9]
2005 | Journal Article | IST-REx-ID: 3417
Automated alignment and pattern recognition of single-molecule force spectroscopy data
M. Kuhn, H.L. Janovjak, M. Hubain, D. Mueller, Journal of Microscopy 218 (2005) 125–132.
View | DOI
 
[8]
2005 | Journal Article | IST-REx-ID: 3416 | OA
Complex stability of single proteins explored by forced unfolding experiments
H.L. Janovjak, T. Sapra, D. Mueller, Biophysical Journal 88 (2005) 37–39.
View | DOI | Download (ext.)
 
[7]
2005 | Journal Article | IST-REx-ID: 3418
Hydrodynamic effects in fast AFM single molecule force measurements
H.L. Janovjak, J. Struckmeier, D. Mueller, European Biophysics Journal 34 (2005) 91–96.
View | DOI
 
[6]
2005 | Journal Article | IST-REx-ID: 3721 | OA
Molecular force modulation spectroscopy revealing the dynamic response of single bacteriorhodopsins
H.L. Janovjak, D. Mueller, A. Humphris, Biophysical Journal 88 (2005) 1423–1431.
View | DOI | Download (ext.)
 
[5]
2004 | Journal Article | IST-REx-ID: 3420
Controlled unfolding and refolding of a single sodium/proton antiporter using atomic force microscopy
A. Kedrov, C. Ziegler, H.L. Janovjak, W. Kühlbrandt, D. Mueller, Journal of Molecular Biology 340 (2004) 1143–1152.
View | DOI
 
[4]
2004 | Journal Article | IST-REx-ID: 3419
Probing the energy landscape of the membrane protein bacteriorhodopsin
H.L. Janovjak, J. Struckmeier, M. Hubain, M. Kessler, A. Kedrov, D. Mueller, Structure 12 (2004) 871–879.
View | DOI
 
[3]
2003 | Journal Article | IST-REx-ID: 3725 | OA
Unfolding pathways of native bacteriorhodopsin depend on temperature
H.L. Janovjak, M. Kessler, D. Oesterhelt, H. Gaub, D. Mueller, EMBO Journal 22 (2003) 5220–5229.
View | DOI | Download (ext.)
 
[2]
2002 | Journal Article | IST-REx-ID: 3421
Observing structure, function and assembly of single proteins by AFM
D. Mueller, H.L. Janovjak, T. Lehto, L. Kuerschner, K. Anderson, Progress in Biophysics and Molecular Biology 79 (2002) 1–43.
View | DOI | PubMed | Europe PMC
 
[1]
2002 | Journal Article | IST-REx-ID: 3422
Processing of gene expression data generated by quantitative real-time RT-PCR
P. Müller, H.L. Janovjak, A. Miserez, Z. Dobbie, Biotechniques 32 (2002) 1372–1379.
View | PubMed | Europe PMC
 
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54 Publications

Mark all

[54]
2021 | Journal Article | IST-REx-ID: 10144 | OA
Acute and chronic effects of a light-activated FGF receptor in keratinocytes in vitro and in mice
T. Rauschendorfer, S. Gurri, I. Heggli, L. Maddaluno, M. Meyer, Á. Inglés Prieto, H.L. Janovjak, S. Werner, Life Science Alliance 4 (2021).
[Published Version] View | Files available | DOI | PubMed | Europe PMC
 
[53]
2021 | Journal Article | IST-REx-ID: 9363 | OA
Optogenetic delivery of trophic signals in a genetic model of Parkinson's disease
Á. Inglés Prieto, N. Furthmann, S.H. Crossman, A.M. Tichy, N. Hoyer, M. Petersen, V. Zheden, J. Bicher, E. Gschaider-Reichhart, A. György, D.E. Siekhaus, P. Soba, K.F. Winklhofer, H.L. Janovjak, PLoS Genetics 17 (2021) e1009479.
[Published Version] View | Files available | DOI | WoS
 
[52]
2020 | Book Chapter | IST-REx-ID: 8173
Design and application of light-regulated receptor tyrosine kinases
S. Kainrath, H.L. Janovjak, in:, D. Niopek (Ed.), Photoswitching Proteins, Springer Nature, 2020, pp. 233–246.
View | DOI
 
[51]
2020 | Journal Article | IST-REx-ID: 8674 | OA
LTP induction boosts glutamate spillover by driving withdrawal of perisynaptic astroglia
Henneberger C, Bard L, Panatier A, Reynolds JP, Kopach O, Medvedev NI, Minge D, Herde MK, Anders S, Kraev I, Heller JP, Rama S, Zheng K, Jensen TP, Sanchez-Romero I, Jackson CJ, Janovjak HL, Ottersen OP, Nagelhus EA, Oliet SHR, Stewart MG, Nägerl UVa, Rusakov DA. 2020. LTP induction boosts glutamate spillover by driving withdrawal of perisynaptic astroglia. Neuron. 108(5), P919–936.E11.
[Published Version] View | Files available | DOI | WoS | PubMed | Europe PMC
 
[50]
2019 | Journal Article | IST-REx-ID: 6025 | OA
Light-activated Frizzled7 reveals a permissive role of non-canonical wnt signaling in mesendoderm cell migration
D. Capek, M. Smutny, A.M. Tichy, M. Morri, H.L. Janovjak, C.-P.J. Heisenberg, ELife 8 (2019).
[Published Version] View | Files available | DOI | WoS
 
[49]
2019 | Journal Article | IST-REx-ID: 6564 | OA
Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions
A.-M. Tichy, E.J. Gerrard, J.M.D. Legrand, R.M. Hobbs, H.L. Janovjak, Journal of Molecular Biology 431 (2019) 3046–3055.
[Preprint] View | DOI | Download Preprint (ext.) | WoS
 
[48]
2019 | Journal Article | IST-REx-ID: 7406
Isolation of synaptic vesicles from genetically engineered cultured neurons
C. Mckenzie, M. Spanova, A.J. Johnson, S. Kainrath, V. Zheden, H.H. Sitte, H.L. Janovjak, Journal of Neuroscience Methods 312 (2019) 114–121.
View | DOI | WoS | PubMed | Europe PMC
 
[47]
2018 | Journal Article | IST-REx-ID: 137 | OA
Monitoring hippocampal glycine with the computationally designed optical sensor GlyFS
W. Zhang, M. Herde, J. Mitchell, J. Whitfield, A. Wulff, V. Vongsouthi, I. Sanchez-Romero, P. Gulakova, D. Minge, B. Breithausen, S. Schoch, H.L. Janovjak, C. Jackson, C. Henneberger, Nature Chemical Biology 14 (2018) 861–869.
[Submitted Version] View | DOI | Download Submitted Version (ext.) | WoS | PubMed | Europe PMC
 
[46]
2018 | Journal Article | IST-REx-ID: 5984 | OA
Optical functionalization of human class A orphan G-protein-coupled receptors
M. Morri, I. Sanchez-Romero, A.-M. Tichy, S. Kainrath, E.J. Gerrard, P. Hirschfeld, J. Schwarz, H.L. Janovjak, Nature Communications 9 (2018).
[Published Version] View | Files available | DOI | WoS
 
[45]
2017 | Journal Article | IST-REx-ID: 538 | OA
Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen
S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie 129 (2017) 4679–4682.
[Published Version] View | Files available | DOI
 
[44]
2017 | Book Chapter | IST-REx-ID: 957
Ancestral protein reconstruction and circular permutation for improving the stability and dynamic range of FRET sensors
B. Clifton, J. Whitfield, I. Sanchez-Romero, M. Herde, C. Henneberger, H.L. Janovjak, C. Jackson, in:, V. Stein (Ed.), Synthetic Protein Switches, Springer, 2017, pp. 71–87.
View | DOI
 
[43]
2017 | Book Chapter | IST-REx-ID: 958
Method for developing optical sensors using a synthetic dye fluorescent protein FRET pair and computational modeling and assessment
J. Mitchell, W. Zhang, M. Herde, C. Henneberger, H.L. Janovjak, M. O’Mara, C. Jackson, in:, V. Stein (Ed.), Synthetic Protein Switches, Springer, 2017, pp. 89–99.
View | DOI
 
[42]
2017 | Journal Article | IST-REx-ID: 1026
Optogenetic methods in drug screening: Technologies and applications
V. Agus, H.L. Janovjak, Current Opinion in Biotechnology 48 (2017) 8–14.
View | DOI | WoS
 
[41]
2017 | Journal Article | IST-REx-ID: 1028 | OA
Green-light-induced inactivation of receptor signaling using cobalamin-binding domains
S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie - International Edition 56 (2017) 4608–4611.
[Published Version] View | Files available | DOI | WoS
 
[40]
2016 | Journal Article | IST-REx-ID: 1440
Light at the end of the protein: Crystal structure of a C-terminal light-sensing domain
H.L. Janovjak, Structure 24 (2016) 213–215.
View | DOI
 
[39]
2016 | Journal Article | IST-REx-ID: 1101
Rangefinder: A semisynthetic FRET sensor design algorithm
J. Mitchell, J. Whitfield, W. Zhang, C. Henneberger, H.L. Janovjak, M. O’Mara, C. Jackson, ACS SENSORS 1 (2016) 1286–1290.
View | DOI
 
[38]
2016 | Journal Article | IST-REx-ID: 1441 | OA
A phytochrome sensory domain permits receptor activation by red light
E. Gschaider-Reichhart, Á. Inglés Prieto, A.-M. Tichy, C. Mckenzie, H.L. Janovjak, Angewandte Chemie - International Edition 55 (2016) 6339–6342.
[Submitted Version] View | Files available | DOI
 
[37]
2016 | Journal Article | IST-REx-ID: 1100 | OA
Optogenetic control of nodal signaling reveals a temporal pattern of nodal signaling regulating cell fate specification during gastrulation
K. Sako, S. Pradhan, V. Barone, Á. Inglés Prieto, P. Mueller, V. Ruprecht, D. Capek, S. Galande, H.L. Janovjak, C.-P.J. Heisenberg, Cell Reports 16 (2016) 866–877.
[Published Version] View | Files available | DOI
 
[36]
2015 | Book Chapter | IST-REx-ID: 1549 | OA
Flipping the photoswitch: Ion channels under light control
C. Mckenzie, I. Sanchez-Romero, H.L. Janovjak, in:, Novel Chemical Tools to Study Ion Channel Biology, Springer, 2015, pp. 101–117.
[Submitted Version] View | Files available | DOI
 
[35]
2015 | Journal Article | IST-REx-ID: 1611 | OA
Construction of a robust and sensitive arginine biosensor through ancestral protein reconstruction
J. Whitfield, W. Zhang, M. Herde, B. Clifton, J. Radziejewski, H.L. Janovjak, C. Henneberger, C. Jackson, Protein Science 24 (2015) 1412–1422.
[Submitted Version] View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 
[34]
2015 | Journal Article | IST-REx-ID: 1867
Quantification of riboflavin, flavin mononucleotide, and flavin adenine dinucleotide in mammalian model cells by CE with LED-induced fluorescence detection
J. Hühner, Á. Inglés Prieto, C. Neusüß, M. Lämmerhofer, H.L. Janovjak, Electrophoresis 36 (2015) 518–525.
View | DOI
 
[33]
2015 | Journal Article | IST-REx-ID: 1678 | OA
Light-assisted small-molecule screening against protein kinases
Á. Inglés Prieto, E. Gschaider-Reichhart, M. Muellner, M. Nowak, S. Nijman, M. Grusch, H.L. Janovjak, Nature Chemical Biology 11 (2015) 952–954.
[Submitted Version] View | Files available | DOI
 
[32]
2014 | Journal Article | IST-REx-ID: 2032 | OA
The optogenetic promise for oncology: Episode I
Á. Inglés Prieto, E. Gschaider-Reichhart, K. Schelch, H.L. Janovjak, M. Grusch, Molecular and Cellular Oncology 1 (2014).
[Published Version] View | Files available | DOI
 
[31]
2014 | Journal Article | IST-REx-ID: 2084 | OA
Spatio-temporally precise activation of engineered receptor tyrosine kinases by light
M. Grusch, K. Schelch, R. Riedler, E. Gschaider-Reichhart, C. Differ, W. Berger, Á. Inglés Prieto, H.L. Janovjak, EMBO Journal 33 (2014) 1713–1726.
[Submitted Version] View | Files available | DOI | Download Submitted Version (ext.)
 
[30]
2013 | Journal Article | IST-REx-ID: 2857 | OA
Optical control of ligand-gated ion channels
S. Szobota, C. Mckenzie, H.L. Janovjak, Methods in Molecular Biology 998 (2013) 417–435.
[Submitted Version] View | Files available | DOI
 
[29]
2013 | Journal Article | IST-REx-ID: 2856 | OA
Optical control of metabotropic glutamate receptors
J. Levitz, C. Pantoja, B. Gaub, H.L. Janovjak, A. Reiner, A. Hoagland, D. Schoppik, B. Kane, P. Stawski, A. Schier, D. Trauner, E. Isacoff, Nature Neuroscience 16 (2013) 507–516.
[Submitted Version] View | DOI | Download Submitted Version (ext.) | PubMed | Europe PMC
 
[28]
2011 | Journal Article | IST-REx-ID: 3405 | OA
Modern ionotropic glutamate receptor with a K+ selectivity signature sequence
H.L. Janovjak, G. Sandoz, E. Isacoff, Nature Communications 2 (2011) 1–6.
[Submitted Version] View | Files available | DOI
 
[27]
2011 | Book Chapter | IST-REx-ID: 3724
Structure-based design of light-controlled proteins
H.L. Janovjak, E. Isacoff, in:, Photosensitive Molecules for the Control of Biological Function, Springer, 2011, pp. 233–266.
View | DOI
 
[26]
2010 | Journal Article | IST-REx-ID: 3407
A light-gated, potassium-selective glutamate receptor for the optical inhibition of neuronal firing
H.L. Janovjak, S. Szobota, C. Wyart, D. Trauner, E. Isacoff, Nature Neuroscience 13 (2010) 1027–1032.
View | DOI
 
[25]
2010 | Book Review | IST-REx-ID: 3406
Pharmacology of ionotropic glutamate receptors: a structural perspective
P. Stawski, H.L. Janovjak, D. Trauner, Bioorganic and Medicinal Chemistry 18 (2010) 7759–7772.
View | DOI
 
[24]
2009 | Journal Article | IST-REx-ID: 3408
Periodic forces trigger a complex mechanical response in ubiquitin
P. Szymczak, H.L. Janovjak, Journal of Molecular Biology 390 (2009) 443–456.
View | DOI
 
[23]
2008 | Book Review | IST-REx-ID: 3410
From valleys to ridges: Exploring the energy landscape of single membrane proteins
H.L. Janovjak, T. Sapra, A. Kedrov, D. Mueller, ChemPhysChem 9 (2008) 954–966.
View | DOI
 
[22]
2008 | Journal Article | IST-REx-ID: 3409
Fully automated single-molecule force spectroscopy for screening applications
J. Struckmeier, R. Wahl, M. Leuschner, J. Nunes, H.L. Janovjak, U. Geisler, G. Hofmann, T. Jähnke, D. Mueller, Nanotechnology 19 (2008).
View | DOI
 
[21]
2008 | Book Chapter | IST-REx-ID: 3726
Single-molecule microscopy and force spectroscopy of membrane proteins
A. Engel, H.L. Janovjak, D. Fotiadis, A. Kedrov, D. Cisneros, D. Mueller, in:, Single Molecules and Nanotechnology, Springer, 2008, pp. 279–311.
View | DOI
 
[20]
2007 | Journal Article | IST-REx-ID: 3411 | OA
Free energy of membrane protein unfolding derived from single-molecule force measurements
J. Preiner, H.L. Janovjak, C. Rankl, H. Knaus, D. Cisneros, A. Kedrov, F. Kienberger, D. Mueller, P. Hinterdorfer, Biophysical Journal 93 (2007) 930–937.
View | DOI | Download (ext.)
 
[19]
2007 | Book Review | IST-REx-ID: 3412
Deciphering molecular interactions of native membrane proteins by single-molecule force spectroscopy
A. Kedrov, H.L. Janovjak, T. Sapra, D. Mueller, Annual Review of Biophysics 36 (2007) 233–260.
View | DOI
 
[18]
2007 | Journal Article | IST-REx-ID: 3727
Digital force-feedback for protein unfolding experiments using atomic force microscopy
C. Bippes, H.L. Janovjak, A. Kedrov, D. Mueller, Nanotechnology 18 (2007).
View | DOI
 
[17]
2007 | Journal Article | IST-REx-ID: 3723
Transmembrane helices have rough energy surfaces
H.L. Janovjak, H. Knaus, D. Mueller, Journal of the American Chemical Society 129 (2007) 246–247.
View | DOI
 
[16]
2006 | Book Chapter | IST-REx-ID: 3404
Atomic force microscopy
H.L. Janovjak, R. Sawhney, M. Stark, D. Mueller, in:, Techniques in Microscopy for Biomedical Applications, World Scientific Publishing, 2006, pp. 213–284.
View
 
[15]
2006 | Journal Article | IST-REx-ID: 3413
Bacteriorhodopsin folds into the membrane against an external force
M. Kessler, K. Gottschalk, H.L. Janovjak, D. Mueller, H. Gaub, Journal of Molecular Biology 357 (2006) 644–654.
View | DOI
 
[14]
2006 | Journal Article | IST-REx-ID: 3414
Observing folding pathways and kinetics of a single sodium-proton antiporter from Escherichia coli
A. Kedrov, H.L. Janovjak, C. Ziegler, W. Kühlbrandt, D. Mueller, Journal of Molecular Biology 355 (2006) 2–8.
View | DOI
 
[13]
2006 | Book Review | IST-REx-ID: 3415
Imaging and detecting molecular interactions of single membrane proteins
H.L. Janovjak, A. Kedrov, D. Cisneros, T. Sapra, J. Struckmeier, D. Mueller, Neurobiology of Aging 27 (2006) 546–561.
View | DOI
 
[12]
2006 | Journal Article | IST-REx-ID: 3729
Direct measurement of single-molecule visco-elasticity in atomic force microscope force-extension experiments
C. Bippes, A. Humphris, M. Stark, D. Mueller, H.L. Janovjak, European Biophysics Journal 35 (2006) 287–292.
View | DOI
 
[11]
2006 | Journal Article | IST-REx-ID: 3728
Pulling single bacteriorhodopsin out of a membrane: Comparison of simulation and experiment
M. Cieplak, S. Filipek, H.L. Janovjak, K. Krzysko, Biochimica et Biophysica Acta (BBA) - Biomembranes 1758 (2006) 537–544.
View | DOI
 
[10]
2006 | Book Chapter | IST-REx-ID: 3722
Rastersondenmikroskopie
H.L. Janovjak, D. Mueller, in:, Bioanalytik, Spektrum Akademischer Verlag, 2006.
View
 
[9]
2005 | Journal Article | IST-REx-ID: 3417
Automated alignment and pattern recognition of single-molecule force spectroscopy data
M. Kuhn, H.L. Janovjak, M. Hubain, D. Mueller, Journal of Microscopy 218 (2005) 125–132.
View | DOI
 
[8]
2005 | Journal Article | IST-REx-ID: 3416 | OA
Complex stability of single proteins explored by forced unfolding experiments
H.L. Janovjak, T. Sapra, D. Mueller, Biophysical Journal 88 (2005) 37–39.
View | DOI | Download (ext.)
 
[7]
2005 | Journal Article | IST-REx-ID: 3418
Hydrodynamic effects in fast AFM single molecule force measurements
H.L. Janovjak, J. Struckmeier, D. Mueller, European Biophysics Journal 34 (2005) 91–96.
View | DOI
 
[6]
2005 | Journal Article | IST-REx-ID: 3721 | OA
Molecular force modulation spectroscopy revealing the dynamic response of single bacteriorhodopsins
H.L. Janovjak, D. Mueller, A. Humphris, Biophysical Journal 88 (2005) 1423–1431.
View | DOI | Download (ext.)
 
[5]
2004 | Journal Article | IST-REx-ID: 3420
Controlled unfolding and refolding of a single sodium/proton antiporter using atomic force microscopy
A. Kedrov, C. Ziegler, H.L. Janovjak, W. Kühlbrandt, D. Mueller, Journal of Molecular Biology 340 (2004) 1143–1152.
View | DOI
 
[4]
2004 | Journal Article | IST-REx-ID: 3419
Probing the energy landscape of the membrane protein bacteriorhodopsin
H.L. Janovjak, J. Struckmeier, M. Hubain, M. Kessler, A. Kedrov, D. Mueller, Structure 12 (2004) 871–879.
View | DOI
 
[3]
2003 | Journal Article | IST-REx-ID: 3725 | OA
Unfolding pathways of native bacteriorhodopsin depend on temperature
H.L. Janovjak, M. Kessler, D. Oesterhelt, H. Gaub, D. Mueller, EMBO Journal 22 (2003) 5220–5229.
View | DOI | Download (ext.)
 
[2]
2002 | Journal Article | IST-REx-ID: 3421
Observing structure, function and assembly of single proteins by AFM
D. Mueller, H.L. Janovjak, T. Lehto, L. Kuerschner, K. Anderson, Progress in Biophysics and Molecular Biology 79 (2002) 1–43.
View | DOI | PubMed | Europe PMC
 
[1]
2002 | Journal Article | IST-REx-ID: 3422
Processing of gene expression data generated by quantitative real-time RT-PCR
P. Müller, H.L. Janovjak, A. Miserez, Z. Dobbie, Biotechniques 32 (2002) 1372–1379.
View | PubMed | Europe PMC
 
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