53 Publications

Mark all

[53]
2019 | Journal Article | IST-REx-ID: 6859
Zhou L, Sazanov LA. Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase. Science. 2019;365(6455):eaaw9144. doi:10.1126/science.aaw9144
View | Files available | DOI | PubMed | Europe PMC
 
[52]
2019 | Journal Article | IST-REx-ID: 6848
Kampjut D, Sazanov LA. Structure and mechanism of mitochondrial proton-translocating transhydrogenase. Nature. 2019. doi:10.1038/s41586-019-1519-2
View | Files available | DOI | PubMed | Europe PMC
 
[51]
2018 | Journal Article | IST-REx-ID: 152   OA
Fiedorczuk K, Sazanov LA. Mammalian mitochondrial complex I structure and disease causing mutations. Trends in Cell Biology. 2018;28(10):835-867. doi:10.1016/j.tcb.2018.06.006
View | Files available | DOI
 
[50]
2017 | Journal Article | IST-REx-ID: 443   OA
Hardie R, Van Dam E, Cowley M, et al. Mitochondrial mutations and metabolic adaptation in pancreatic cancer. Cancer & Metabolism. 2017;5(2). doi:10.1186/s40170-017-0164-1
View | Files available | DOI
 
[49]
2017 | Book Chapter | IST-REx-ID: 444
Sazanov LA. Structure of respiratory complex I: “Minimal” bacterial and “de luxe” mammalian versions. In: Wikström M, ed. Mechanisms of Primary Energy Transduction in Biology . Mechanisms of Primary Energy Transduction in Biology . Royal Society of Chemistry; 2017:25-59. doi:10.1039/9781788010405-00025
View | DOI
 
[48]
2017 | Journal Article | IST-REx-ID: 515   OA
Letts JA, Sazanov LA. Clarifying the supercomplex: The higher-order organization of the mitochondrial electron transport chain. Nature Structural and Molecular Biology. 2017;24(10):800-808. doi:10.1038/nsmb.3460
View | Files available | DOI
 
[47]
2016 | Journal Article | IST-REx-ID: 1232
Letts JA, Fiedorczuk K, Sazanov LA. The architecture of respiratory supercomplexes. Nature. 2016;537(7622):644-648. doi:10.1038/nature19774
View | DOI
 
[46]
2016 | Journal Article | IST-REx-ID: 1226
Fiedorczuk K, Letts JA, Degliesposti G, Kaszuba K, Skehel M, Sazanov LA. Atomic structure of the entire mammalian mitochondrial complex i. Nature. 2016;538(7625):406-410. doi:10.1038/nature19794
View | DOI
 
[45]
2016 | Journal Article | IST-REx-ID: 1288
Holt P, Efremov R, Nakamaru Ogiso E, Sazanov LA. Reversible FMN dissociation from Escherichia coli respiratory complex I. Biochimica et Biophysica Acta - Bioenergetics. 2016;1857(11):1777-1785. doi:10.1016/j.bbabio.2016.08.008
View | DOI
 
[44]
2016 | Journal Article | IST-REx-ID: 1209   OA
Letts JA, Degliesposti G, Fiedorczuk K, Skehel M, Sazanov LA. Purification of ovine respiratory complex i results in a highly active and stable preparation. Journal of Biological Chemistry. 2016;291(47):24657-24675. doi:10.1074/jbc.M116.735142
View | DOI | Download (ext.)
 
[43]
2016 | Journal Article | IST-REx-ID: 1521
Berrisford J, Baradaran R, Sazanov LA. Structure of bacterial respiratory complex I. Biochimica et Biophysica Acta - Bioenergetics. 2016;1857(7):892-901. doi:10.1016/j.bbabio.2016.01.012
View | DOI
 
[42]
2015 | Journal Article | IST-REx-ID: 1638
Sazanov LA. A giant molecular proton pump: structure and mechanism of respiratory complex I. Nature Reviews Molecular Cell Biology. 2015;16(6):375-388. doi:10.1038/nrm3997
View | DOI
 
[41]
2015 | Journal Article | IST-REx-ID: 1683
Letts JA, Sazanov LA. Gaining mass: The structure of respiratory complex I-from bacterial towards mitochondrial versions. Current Opinion in Structural Biology. 2015;33(8):135-145. doi:10.1016/j.sbi.2015.08.008
View | DOI
 
[40]
2014 | Journal Article | IST-REx-ID: 1980
Heikal A, Nakatani Y, Dunn E, et al. Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation. Molecular Microbiology. 2014;91(5):950-964. doi:10.1111/mmi.12507
View | DOI
 
[39]
2014 | Journal Article | IST-REx-ID: 1979
Sazanov LA. The mechanism of coupling between electron transfer and proton translocation in respiratory complex I. Journal of Bioenergetics and Biomembranes. 2014;46(4):247-253. doi:10.1007/s10863-014-9554-z
View | DOI
 
[38]
2014 | Book Review | IST-REx-ID: 1981
Garvin M, Bielawski J, Sazanov LA, Gharrett A. Review and meta-analysis of natural selection in mitochondrial complex I in metazoans. Journal of Zoological Systematics and Evolutionary Research. 2014;53(1):1-17. doi:10.1111/jzs.12079
View | DOI
 
[37]
2013 | Journal Article | IST-REx-ID: 1977
Sazanov LA, Baradaran R, Efremov R, Berrisford J, Minhas G. A long road towards the structure of respiratory complex I, a giant molecular proton pump. Biochemical Society Transactions. 2013;41(5):1265-1271. doi:10.1042/BST20130193
View | DOI
 
[36]
2013 | Journal Article | IST-REx-ID: 1978
Baradaran R, Berrisford J, Minhas G, Sazanov LA. Crystal structure of the entire respiratory complex i. Nature. 2013;494(7438):443-448. doi:10.1038/nature11871
View | DOI
 
[35]
2012 | Book Review | IST-REx-ID: 1976
Efremov R, Sazanov LA. The coupling mechanism of respiratory complex i - A structural and evolutionary perspective. Biochimica et Biophysica Acta - Bioenergetics. 2012;1817(10):1785-1795. doi:10.1016/j.bbabio.2012.02.015
View | DOI
 
[34]
2012 | Journal Article | IST-REx-ID: 1972
Efremov R, Sazanov LA. Structure of Escherichia coli OmpF porin from lipidic mesophase. Journal of Structural Biology. 2012;178(3):311-318. doi:10.1016/j.jsb.2012.03.005
View | DOI
 
[33]
2011 | Journal Article | IST-REx-ID: 1973
Efremov R, Sazanov LA. Structure of the membrane domain of respiratory complex i. Nature. 2011;476(7361):414-421. doi:10.1038/nature10330
View | DOI
 
[32]
2011 | Journal Article | IST-REx-ID: 1974
Efremov R, Sazanov LA. Respiratory complex I: “steam engine” of the cell? Current Opinion in Structural Biology. 2011;21(4):532-540. doi:10.1016/j.sbi.2011.07.002
View | DOI
 
[31]
2011 | Journal Article | IST-REx-ID: 1975
Yip C, Harbour M, Jayawardena K, Fearnley I, Sazanov LA. Evolution of respiratory complex I "Supernumerary" subunits are present in the α-proteobacterial enzyme. Journal of Biological Chemistry. 2011;286(7):5023-5033. doi:10.1074/jbc.M110.194993
View | DOI
 
[30]
2010 | Journal Article | IST-REx-ID: 1970
Efremov R, Baradaran R, Sazanov LA. The architecture of respiratory complex I. Nature. 2010;465(7297):441-445. doi:10.1038/nature09066
View | DOI
 
[29]
2009 | Journal Article | IST-REx-ID: 1971
Berrisford J, Sazanov LA. Structural basis for the mechanism of respiratory complex I. Journal of Biological Chemistry. 2009;284(43):29773-29783. doi:10.1074/jbc.M109.032144
View | DOI
 
[28]
2008 | Journal Article | IST-REx-ID: 1967
Berrisford J, Thompson C, Sazanov LA. Chemical and NADH-induced, ROS-dependent, cross-linking between sublimits of complex I from Escherichia coli and Thermus thermophilus. Biochemistry. 2008;47(39):10262-10270. doi:10.1021/bi801160u
View | DOI
 
[27]
2008 | Journal Article | IST-REx-ID: 1968
Morgan D, Sazanov LA. Three-dimensional structure of respiratory complex I from Escherichia coli in ice in the presence of nucleotides. Biochimica et Biophysica Acta - Bioenergetics. 2008;1777(7-8):711-718. doi:10.1016/j.bbabio.2008.03.023
View | DOI
 
[26]
2007 | Journal Article | IST-REx-ID: 1964
Sazanov LA. Respiratory complex I: Mechanistic and structural insights provided by the crystal structure of the hydrophilic domain. Biochemistry. 2007;46(9):2275-2288. doi:10.1021/bi602508x
View | DOI
 
[25]
2007 | Journal Article | IST-REx-ID: 1969
Baranova E, Morgan D, Sazanov LA. Single particle analysis confirms distal location of subunits NuoL and NuoM in Escherichia coli complex I. Journal of Structural Biology. 2007;159(2 SPEC. ISS.):238-242. doi:10.1016/j.jsb.2007.01.009
View | DOI
 
[24]
2007 | Journal Article | IST-REx-ID: 1965
Baranova E, Holt P, Sazanov LA. Projection structure of the membrane domain of Escherichia coli respiratory Complex I at 8 Å resolution. Journal of Molecular Biology. 2007;366(1):140-154. doi:10.1016/j.jmb.2006.11.026
View | DOI
 
[23]
2006 | Journal Article | IST-REx-ID: 1961
Sazanov LA, Hinchliffe P. Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus. Science. 2006;311(5766):1430-1436. doi:10.1126/science.1123809
View | DOI
 
[22]
2006 | Journal Article | IST-REx-ID: 1966
Hinchliffe P, Carroll J, Sazanov LA. Identification of a novel subunit of respiratory complex I from Thermus thermophilus. Biochemistry. 2006;45(14):4413-4420. doi:10.1021/bi0600998
View | DOI
 
[21]
2005 | Journal Article | IST-REx-ID: 1962
Hinchliffe P, Sazanov LA. Biochemistry: Organization of iron-sulfur clusters in respiratory complex I. Science. 2005;309(5735):771-774. doi:10.1126/science.1113988
View | DOI
 
[20]
2004 | Journal Article | IST-REx-ID: 1963
Mamedova A, Holt P, Carroll J, Sazanov LA. Substrate-induced conformational change in bacterial complex I. Journal of Biological Chemistry. 2004;279(22):23830-23836. doi:10.1074/jbc.M401539200
View | DOI
 
[19]
2003 | Journal Article | IST-REx-ID: 1960
Sazanov LA, Carroll J, Holt P, Toime L, Fearnley I. A role for native lipids in the stabilization and two dimensional crystallization of the Escherichia coli NADH ubiquinone oxidoreductase (complex I). Journal of Biological Chemistry. 2003;278(21):19483-19491. doi:10.1074/jbc.M208959200
View | DOI
 
[18]
2003 | Journal Article | IST-REx-ID: 1959
Holt P, Morgan D, Sazanov LA. The location of NuoL and NuoM subunits in the membrane domain of the Escherichia coli Complex I: implications for the mechanism of proton pumping. Journal of Biological Chemistry. 2003;278(44):43114-43120. doi:10.1074/jbc.M308247200
View | DOI
 
[17]
2000 | Journal Article | IST-REx-ID: 1957
Sazanov LA, Walker J. Cryo-electron crystallography of two sub-complexes of bovine complex I reveals the relationship between the membrane and peripheral arms. Journal of Molecular Biology. 2000;302(2):455-464. doi:10.1006/jmbi.2000.4079
View | DOI
 
[16]
2000 | Journal Article | IST-REx-ID: 1958
Sazanov LA, Peak Chew S, Fearnley I, Walker J. Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme. Biochemistry. 2000;39(24):7229-7235. doi:10.1021/bi000335t
View | DOI
 
[15]
1998 | Journal Article | IST-REx-ID: 1954
Sazanov LA, Burrows P, Nixon P. The chloroplast Ndh complex mediates the dark reduction of the plastoquinone pool in response to heat stress in tobacco leaves. FEBS Letters. 1998;429(1):115-118. doi:10.1016/S0014-5793(98)00573-0
View | DOI
 
[14]
1998 | Journal Article | IST-REx-ID: 1955   OA
Burrows P, Sazanov LA, Sváb Z, Maliga P, Nixon P. Identification of a functional respiratory complex in chloroplasts through analysis of tobacco mutants containing disrupted plastid ndh genes. EMBO Journal. 1998;17(4):868-876. doi:10.1093/emboj/17.4.868
View | DOI | Download (ext.)
 
[13]
1998 | Journal Article | IST-REx-ID: 1956
Sazanov LA, Burrows P, Nixon P. The plastid ndh genes code for an NADH-specific dehydrogenase: Isolation of a complex I analogue from pea thylakoid membranes. PNAS. 1998;95(3):1319-1324. doi:10.1073/pnas.95.3.1319
View | DOI
 
[12]
1996 | Journal Article | IST-REx-ID: 1952
Bizouarn T, Sazanov LA, Aubourg S, Jackson J. Estimation of the H+/H- ratio of the reaction catalysed by the nicotinamide nucleotide transhydrogenase in chromatophores from over-expressing strains of Rhodospirillum rubrum and in liposomes inlaid with the purified bovine enzyme. Biochimica et Biophysica Acta - Bioenergetics. 1996;1273(1):4-12. doi:10.1016/0005-2728(95)00125-5
View | DOI
 
[11]
1996 | Conference Paper | IST-REx-ID: 1942
Sazanov LA, Burrows P, Nixon PJ. Presence of a large protein complex containing the ndhK gene product and possessing NADH-specific dehydrogenase activity in thylakoid membranes of higher plant chloroplasts. In: Vol 2. Kluwer; 1996:705-708.
View
 
[10]
1996 | Journal Article | IST-REx-ID: 1951
Sazanov LA, Burrows P, Nixon P. Detection and characterization of a complex I-like NADH-specific dehydrogenase from pea thylakoids. Biochemical Society Transactions. 1996;24(3):739-743.
View
 
[9]
1995 | Journal Article | IST-REx-ID: 1943
Sazanov LA, Jackson B. Cyclic reactions catalysed by detergent-dispersed and reconstituted transhydrogenase from beef heart mitochondria; implications for the mechanism of proton translocation. Biochimica et Biophysica Acta - Bioenergetics. 1995;1231(3):304-312. doi:10.1016/0005-2728(95)00096-2
View | DOI
 
[8]
1994 | Journal Article | IST-REx-ID: 1953
Efanov A, Koshkin A, Sazanov LA, Borodulina OI, Varfolomeev S, Zaǐtsev S. Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism. FEBS Letters. 1994;355(2):114-116. doi:10.1016/0014-5793(94)01109-5
View | DOI
 
[7]
1994 | Journal Article | IST-REx-ID: 1949
Sazanov LA, Jackson J. Proton translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria. FEBS Letters. 1994;344(2-3):109-116. doi:10.1016/0014-5793(94)00370-X
View | DOI
 
[6]
1993 | Journal Article | IST-REx-ID: 1947
Sazanov LA, Jackson J. Activation and inhibition of mitochondrial transhydrogenase by metal ions. Biochimica et Biophysica Acta - Bioenergetics. 1993;1144(2):225-228. doi:10.1016/0005-2728(93)90177-H
View | DOI
 
[5]
1993 | Journal Article | IST-REx-ID: 1948
Sazanov LA, Jackson J. Possible functions of the NADP-linked isocitrate dehydrogenase and H+ -transhydrogenase in heart mitochondria . Biochemical Society Transactions. 1993;21(3).
View
 
[4]
1993 | Journal Article | IST-REx-ID: 1950
Jackson J, Cotton NPJ, Williams R, et al. Proton-translocating transhydrogenase in bacteria. Biochemical Society Transactions. 1993;21(4):1010-1013.
View
 
[3]
1992 | Journal Article | IST-REx-ID: 1945
Sazanov LA, Zaǐtsev S. Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms. Biokhimiya. 1992;57(10):1443-1460.
View
 
[2]
1991 | Journal Article | IST-REx-ID: 1946
Zaǐtsev S, Sazanov LA, Koshkin A, Sud’Ina G, Varfolomeev S. Respiratory burst inhibition in human neutrophils by ultra-low doses of [D-Ala2] methionine enkephalinamide. FEBS Letters. 1991;291(1):84-86. doi:10.1016/0014-5793(91)81109-L
View | DOI
 
[1]
1988 | Journal Article | IST-REx-ID: 1941
Sazanov LA, Karavaev VA, Kukushkin AK. Mathematical model of photosynthesis regulation accounts for the effects of changes in external conditions and observed oscillations. J Phys Chem-Russia. 1988;52:3351-3354.
View
 

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53 Publications

Mark all

[53]
2019 | Journal Article | IST-REx-ID: 6859
Zhou L, Sazanov LA. Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase. Science. 2019;365(6455):eaaw9144. doi:10.1126/science.aaw9144
View | Files available | DOI | PubMed | Europe PMC
 
[52]
2019 | Journal Article | IST-REx-ID: 6848
Kampjut D, Sazanov LA. Structure and mechanism of mitochondrial proton-translocating transhydrogenase. Nature. 2019. doi:10.1038/s41586-019-1519-2
View | Files available | DOI | PubMed | Europe PMC
 
[51]
2018 | Journal Article | IST-REx-ID: 152   OA
Fiedorczuk K, Sazanov LA. Mammalian mitochondrial complex I structure and disease causing mutations. Trends in Cell Biology. 2018;28(10):835-867. doi:10.1016/j.tcb.2018.06.006
View | Files available | DOI
 
[50]
2017 | Journal Article | IST-REx-ID: 443   OA
Hardie R, Van Dam E, Cowley M, et al. Mitochondrial mutations and metabolic adaptation in pancreatic cancer. Cancer & Metabolism. 2017;5(2). doi:10.1186/s40170-017-0164-1
View | Files available | DOI
 
[49]
2017 | Book Chapter | IST-REx-ID: 444
Sazanov LA. Structure of respiratory complex I: “Minimal” bacterial and “de luxe” mammalian versions. In: Wikström M, ed. Mechanisms of Primary Energy Transduction in Biology . Mechanisms of Primary Energy Transduction in Biology . Royal Society of Chemistry; 2017:25-59. doi:10.1039/9781788010405-00025
View | DOI
 
[48]
2017 | Journal Article | IST-REx-ID: 515   OA
Letts JA, Sazanov LA. Clarifying the supercomplex: The higher-order organization of the mitochondrial electron transport chain. Nature Structural and Molecular Biology. 2017;24(10):800-808. doi:10.1038/nsmb.3460
View | Files available | DOI
 
[47]
2016 | Journal Article | IST-REx-ID: 1232
Letts JA, Fiedorczuk K, Sazanov LA. The architecture of respiratory supercomplexes. Nature. 2016;537(7622):644-648. doi:10.1038/nature19774
View | DOI
 
[46]
2016 | Journal Article | IST-REx-ID: 1226
Fiedorczuk K, Letts JA, Degliesposti G, Kaszuba K, Skehel M, Sazanov LA. Atomic structure of the entire mammalian mitochondrial complex i. Nature. 2016;538(7625):406-410. doi:10.1038/nature19794
View | DOI
 
[45]
2016 | Journal Article | IST-REx-ID: 1288
Holt P, Efremov R, Nakamaru Ogiso E, Sazanov LA. Reversible FMN dissociation from Escherichia coli respiratory complex I. Biochimica et Biophysica Acta - Bioenergetics. 2016;1857(11):1777-1785. doi:10.1016/j.bbabio.2016.08.008
View | DOI
 
[44]
2016 | Journal Article | IST-REx-ID: 1209   OA
Letts JA, Degliesposti G, Fiedorczuk K, Skehel M, Sazanov LA. Purification of ovine respiratory complex i results in a highly active and stable preparation. Journal of Biological Chemistry. 2016;291(47):24657-24675. doi:10.1074/jbc.M116.735142
View | DOI | Download (ext.)
 
[43]
2016 | Journal Article | IST-REx-ID: 1521
Berrisford J, Baradaran R, Sazanov LA. Structure of bacterial respiratory complex I. Biochimica et Biophysica Acta - Bioenergetics. 2016;1857(7):892-901. doi:10.1016/j.bbabio.2016.01.012
View | DOI
 
[42]
2015 | Journal Article | IST-REx-ID: 1638
Sazanov LA. A giant molecular proton pump: structure and mechanism of respiratory complex I. Nature Reviews Molecular Cell Biology. 2015;16(6):375-388. doi:10.1038/nrm3997
View | DOI
 
[41]
2015 | Journal Article | IST-REx-ID: 1683
Letts JA, Sazanov LA. Gaining mass: The structure of respiratory complex I-from bacterial towards mitochondrial versions. Current Opinion in Structural Biology. 2015;33(8):135-145. doi:10.1016/j.sbi.2015.08.008
View | DOI
 
[40]
2014 | Journal Article | IST-REx-ID: 1980
Heikal A, Nakatani Y, Dunn E, et al. Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation. Molecular Microbiology. 2014;91(5):950-964. doi:10.1111/mmi.12507
View | DOI
 
[39]
2014 | Journal Article | IST-REx-ID: 1979
Sazanov LA. The mechanism of coupling between electron transfer and proton translocation in respiratory complex I. Journal of Bioenergetics and Biomembranes. 2014;46(4):247-253. doi:10.1007/s10863-014-9554-z
View | DOI
 
[38]
2014 | Book Review | IST-REx-ID: 1981
Garvin M, Bielawski J, Sazanov LA, Gharrett A. Review and meta-analysis of natural selection in mitochondrial complex I in metazoans. Journal of Zoological Systematics and Evolutionary Research. 2014;53(1):1-17. doi:10.1111/jzs.12079
View | DOI
 
[37]
2013 | Journal Article | IST-REx-ID: 1977
Sazanov LA, Baradaran R, Efremov R, Berrisford J, Minhas G. A long road towards the structure of respiratory complex I, a giant molecular proton pump. Biochemical Society Transactions. 2013;41(5):1265-1271. doi:10.1042/BST20130193
View | DOI
 
[36]
2013 | Journal Article | IST-REx-ID: 1978
Baradaran R, Berrisford J, Minhas G, Sazanov LA. Crystal structure of the entire respiratory complex i. Nature. 2013;494(7438):443-448. doi:10.1038/nature11871
View | DOI
 
[35]
2012 | Book Review | IST-REx-ID: 1976
Efremov R, Sazanov LA. The coupling mechanism of respiratory complex i - A structural and evolutionary perspective. Biochimica et Biophysica Acta - Bioenergetics. 2012;1817(10):1785-1795. doi:10.1016/j.bbabio.2012.02.015
View | DOI
 
[34]
2012 | Journal Article | IST-REx-ID: 1972
Efremov R, Sazanov LA. Structure of Escherichia coli OmpF porin from lipidic mesophase. Journal of Structural Biology. 2012;178(3):311-318. doi:10.1016/j.jsb.2012.03.005
View | DOI
 
[33]
2011 | Journal Article | IST-REx-ID: 1973
Efremov R, Sazanov LA. Structure of the membrane domain of respiratory complex i. Nature. 2011;476(7361):414-421. doi:10.1038/nature10330
View | DOI
 
[32]
2011 | Journal Article | IST-REx-ID: 1974
Efremov R, Sazanov LA. Respiratory complex I: “steam engine” of the cell? Current Opinion in Structural Biology. 2011;21(4):532-540. doi:10.1016/j.sbi.2011.07.002
View | DOI
 
[31]
2011 | Journal Article | IST-REx-ID: 1975
Yip C, Harbour M, Jayawardena K, Fearnley I, Sazanov LA. Evolution of respiratory complex I "Supernumerary" subunits are present in the α-proteobacterial enzyme. Journal of Biological Chemistry. 2011;286(7):5023-5033. doi:10.1074/jbc.M110.194993
View | DOI
 
[30]
2010 | Journal Article | IST-REx-ID: 1970
Efremov R, Baradaran R, Sazanov LA. The architecture of respiratory complex I. Nature. 2010;465(7297):441-445. doi:10.1038/nature09066
View | DOI
 
[29]
2009 | Journal Article | IST-REx-ID: 1971
Berrisford J, Sazanov LA. Structural basis for the mechanism of respiratory complex I. Journal of Biological Chemistry. 2009;284(43):29773-29783. doi:10.1074/jbc.M109.032144
View | DOI
 
[28]
2008 | Journal Article | IST-REx-ID: 1967
Berrisford J, Thompson C, Sazanov LA. Chemical and NADH-induced, ROS-dependent, cross-linking between sublimits of complex I from Escherichia coli and Thermus thermophilus. Biochemistry. 2008;47(39):10262-10270. doi:10.1021/bi801160u
View | DOI
 
[27]
2008 | Journal Article | IST-REx-ID: 1968
Morgan D, Sazanov LA. Three-dimensional structure of respiratory complex I from Escherichia coli in ice in the presence of nucleotides. Biochimica et Biophysica Acta - Bioenergetics. 2008;1777(7-8):711-718. doi:10.1016/j.bbabio.2008.03.023
View | DOI
 
[26]
2007 | Journal Article | IST-REx-ID: 1964
Sazanov LA. Respiratory complex I: Mechanistic and structural insights provided by the crystal structure of the hydrophilic domain. Biochemistry. 2007;46(9):2275-2288. doi:10.1021/bi602508x
View | DOI
 
[25]
2007 | Journal Article | IST-REx-ID: 1969
Baranova E, Morgan D, Sazanov LA. Single particle analysis confirms distal location of subunits NuoL and NuoM in Escherichia coli complex I. Journal of Structural Biology. 2007;159(2 SPEC. ISS.):238-242. doi:10.1016/j.jsb.2007.01.009
View | DOI
 
[24]
2007 | Journal Article | IST-REx-ID: 1965
Baranova E, Holt P, Sazanov LA. Projection structure of the membrane domain of Escherichia coli respiratory Complex I at 8 Å resolution. Journal of Molecular Biology. 2007;366(1):140-154. doi:10.1016/j.jmb.2006.11.026
View | DOI
 
[23]
2006 | Journal Article | IST-REx-ID: 1961
Sazanov LA, Hinchliffe P. Structure of the hydrophilic domain of respiratory complex I from Thermus thermophilus. Science. 2006;311(5766):1430-1436. doi:10.1126/science.1123809
View | DOI
 
[22]
2006 | Journal Article | IST-REx-ID: 1966
Hinchliffe P, Carroll J, Sazanov LA. Identification of a novel subunit of respiratory complex I from Thermus thermophilus. Biochemistry. 2006;45(14):4413-4420. doi:10.1021/bi0600998
View | DOI
 
[21]
2005 | Journal Article | IST-REx-ID: 1962
Hinchliffe P, Sazanov LA. Biochemistry: Organization of iron-sulfur clusters in respiratory complex I. Science. 2005;309(5735):771-774. doi:10.1126/science.1113988
View | DOI
 
[20]
2004 | Journal Article | IST-REx-ID: 1963
Mamedova A, Holt P, Carroll J, Sazanov LA. Substrate-induced conformational change in bacterial complex I. Journal of Biological Chemistry. 2004;279(22):23830-23836. doi:10.1074/jbc.M401539200
View | DOI
 
[19]
2003 | Journal Article | IST-REx-ID: 1960
Sazanov LA, Carroll J, Holt P, Toime L, Fearnley I. A role for native lipids in the stabilization and two dimensional crystallization of the Escherichia coli NADH ubiquinone oxidoreductase (complex I). Journal of Biological Chemistry. 2003;278(21):19483-19491. doi:10.1074/jbc.M208959200
View | DOI
 
[18]
2003 | Journal Article | IST-REx-ID: 1959
Holt P, Morgan D, Sazanov LA. The location of NuoL and NuoM subunits in the membrane domain of the Escherichia coli Complex I: implications for the mechanism of proton pumping. Journal of Biological Chemistry. 2003;278(44):43114-43120. doi:10.1074/jbc.M308247200
View | DOI
 
[17]
2000 | Journal Article | IST-REx-ID: 1957
Sazanov LA, Walker J. Cryo-electron crystallography of two sub-complexes of bovine complex I reveals the relationship between the membrane and peripheral arms. Journal of Molecular Biology. 2000;302(2):455-464. doi:10.1006/jmbi.2000.4079
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[16]
2000 | Journal Article | IST-REx-ID: 1958
Sazanov LA, Peak Chew S, Fearnley I, Walker J. Resolution of the membrane domain of bovine complex I into subcomplexes: implications for the structural organization of the enzyme. Biochemistry. 2000;39(24):7229-7235. doi:10.1021/bi000335t
View | DOI
 
[15]
1998 | Journal Article | IST-REx-ID: 1954
Sazanov LA, Burrows P, Nixon P. The chloroplast Ndh complex mediates the dark reduction of the plastoquinone pool in response to heat stress in tobacco leaves. FEBS Letters. 1998;429(1):115-118. doi:10.1016/S0014-5793(98)00573-0
View | DOI
 
[14]
1998 | Journal Article | IST-REx-ID: 1955   OA
Burrows P, Sazanov LA, Sváb Z, Maliga P, Nixon P. Identification of a functional respiratory complex in chloroplasts through analysis of tobacco mutants containing disrupted plastid ndh genes. EMBO Journal. 1998;17(4):868-876. doi:10.1093/emboj/17.4.868
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[13]
1998 | Journal Article | IST-REx-ID: 1956
Sazanov LA, Burrows P, Nixon P. The plastid ndh genes code for an NADH-specific dehydrogenase: Isolation of a complex I analogue from pea thylakoid membranes. PNAS. 1998;95(3):1319-1324. doi:10.1073/pnas.95.3.1319
View | DOI
 
[12]
1996 | Journal Article | IST-REx-ID: 1952
Bizouarn T, Sazanov LA, Aubourg S, Jackson J. Estimation of the H+/H- ratio of the reaction catalysed by the nicotinamide nucleotide transhydrogenase in chromatophores from over-expressing strains of Rhodospirillum rubrum and in liposomes inlaid with the purified bovine enzyme. Biochimica et Biophysica Acta - Bioenergetics. 1996;1273(1):4-12. doi:10.1016/0005-2728(95)00125-5
View | DOI
 
[11]
1996 | Conference Paper | IST-REx-ID: 1942
Sazanov LA, Burrows P, Nixon PJ. Presence of a large protein complex containing the ndhK gene product and possessing NADH-specific dehydrogenase activity in thylakoid membranes of higher plant chloroplasts. In: Vol 2. Kluwer; 1996:705-708.
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[10]
1996 | Journal Article | IST-REx-ID: 1951
Sazanov LA, Burrows P, Nixon P. Detection and characterization of a complex I-like NADH-specific dehydrogenase from pea thylakoids. Biochemical Society Transactions. 1996;24(3):739-743.
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[9]
1995 | Journal Article | IST-REx-ID: 1943
Sazanov LA, Jackson B. Cyclic reactions catalysed by detergent-dispersed and reconstituted transhydrogenase from beef heart mitochondria; implications for the mechanism of proton translocation. Biochimica et Biophysica Acta - Bioenergetics. 1995;1231(3):304-312. doi:10.1016/0005-2728(95)00096-2
View | DOI
 
[8]
1994 | Journal Article | IST-REx-ID: 1953
Efanov A, Koshkin A, Sazanov LA, Borodulina OI, Varfolomeev S, Zaǐtsev S. Inhibition of the respiratory burst in mouse macrophages by ultra-low doses of an opioid peptide is consistent with a possible adaptation mechanism. FEBS Letters. 1994;355(2):114-116. doi:10.1016/0014-5793(94)01109-5
View | DOI
 
[7]
1994 | Journal Article | IST-REx-ID: 1949
Sazanov LA, Jackson J. Proton translocating transhydrogenase and NAD- and NADP-linked isocitrate dehydrogenases operate in a substrate cycle which contributes to fine regulation of the tricarboxylic acid cycle activity in mitochondria. FEBS Letters. 1994;344(2-3):109-116. doi:10.1016/0014-5793(94)00370-X
View | DOI
 
[6]
1993 | Journal Article | IST-REx-ID: 1947
Sazanov LA, Jackson J. Activation and inhibition of mitochondrial transhydrogenase by metal ions. Biochimica et Biophysica Acta - Bioenergetics. 1993;1144(2):225-228. doi:10.1016/0005-2728(93)90177-H
View | DOI
 
[5]
1993 | Journal Article | IST-REx-ID: 1948
Sazanov LA, Jackson J. Possible functions of the NADP-linked isocitrate dehydrogenase and H+ -transhydrogenase in heart mitochondria . Biochemical Society Transactions. 1993;21(3).
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[4]
1993 | Journal Article | IST-REx-ID: 1950
Jackson J, Cotton NPJ, Williams R, et al. Proton-translocating transhydrogenase in bacteria. Biochemical Society Transactions. 1993;21(4):1010-1013.
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[3]
1992 | Journal Article | IST-REx-ID: 1945
Sazanov LA, Zaǐtsev S. Effect of superlow doses (10(-18)-10-(-14) M) of biologically active substances: general rules, features, and possible mechanisms. Biokhimiya. 1992;57(10):1443-1460.
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[2]
1991 | Journal Article | IST-REx-ID: 1946
Zaǐtsev S, Sazanov LA, Koshkin A, Sud’Ina G, Varfolomeev S. Respiratory burst inhibition in human neutrophils by ultra-low doses of [D-Ala2] methionine enkephalinamide. FEBS Letters. 1991;291(1):84-86. doi:10.1016/0014-5793(91)81109-L
View | DOI
 
[1]
1988 | Journal Article | IST-REx-ID: 1941
Sazanov LA, Karavaev VA, Kukushkin AK. Mathematical model of photosynthesis regulation accounts for the effects of changes in external conditions and observed oscillations. J Phys Chem-Russia. 1988;52:3351-3354.
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