---
_id: '14852'
abstract:
- lang: eng
text: The physical conditions giving rise to high escape fractions of ionizing radiation
(LyC fesc) in star-forming galaxies – most likely protagonists of cosmic reionization
– are not yet fully understood. Using the VLT/MUSE observations of ∼1400 Ly α
emitters at 2.9 < z < 6.7, we compare stacked rest-frame UV spectra
of candidates for LyC leakers and non-leakers selected based on their Ly α profiles.
We find that the stacks of potential LyC leakers, i.e. galaxies with narrow, symmetric
Ly α profiles with small peak separation, generally show (i) strong nebular O iii]λ1666,
[Si iii]λ1883, and [C iii]λ1907 +C iii]λ1909 emission, indicating a high-ionization
state of the interstellar medium (ISM); (ii) high equivalent widths of He iiλ1640
(∼1 − 3 Å), suggesting the presence of hard ionizing radiation fields; (iii) Si ii*λ1533
emission, revealing substantial amounts of neutral hydrogen off the line of sight;
(iv) high C ivλλ1548,1550 to [C iii]λ1907 +C iii]λ1909 ratios (C iv/C iii] ≳0.75)
, signalling the presence of low column density channels in the ISM. In contrast,
the stacks with broad, asymmetric Ly α profiles with large peak separation show
weak nebular emission lines, low He iiλ1640 equivalent widths (≲1 Å), and low
C iv/C iii] (≲0.25), implying low-ionization states and high-neutral hydrogen
column densities. Our results suggest that C iv/C iii] might be sensitive to the
physical conditions that govern LyC photon escape, providing a promising tool
for identification of ionizing sources among star-forming galaxies in the epoch
of reionization.
acknowledgement: 'We thank the anonymous referee for the constructive feedback that
helped to improve the manuscript. We thank Michael Maseda, Daniel Schaerer, Charlotte
Simmonds, and Rashmi Gottumukkala for useful comments and productive discussions.
We also thank the organizers and participants of the 24th MUSE Science Busy Week
in Leiden. IGK acknowledges an Excellence Master Fellowship granted by the Faculty
of Science of the University of Geneva. This work has received funding from the
Swiss State Secretariat for Education, Research and Innovation (SERI) under contract
number MB22.00072, as well as from the Swiss National Science Foundation (SNSF)
through project grant number 200020_207349 and SNSF Professorship grant number 190079.
The Cosmic Dawn Center (DAWN) is funded by the Danish National Research Foundation
under grant number 140. This paper is based on observations collected at the European
Organisation for Astronomical Research in the Southern Hemisphere under ESO programmes
094.A-0289(B), 095.A-0010(A), 096.A-0045(A), 096.A-0045(B), 094.A-0205, 095.A-0240,
096.A-0090, 097.A-0160, and 098.A-0017. We made extensive use of several open-source
software packages and we are thankful to the respective authors for sharing their
work: NUMPY (Harris et al. 2020), ASTROPY (Astropy Collaboration 2022), MATPLOTLIB
(Hunter 2007), IPYTHON (Perez & Granger 2007), and TOPCAT (Taylor 2005).'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Ivan
full_name: Kramarenko, Ivan
id: 9a9394cb-3200-11ee-973b-f5ba2a8b16e4
last_name: Kramarenko
- first_name: J
full_name: Kerutt, J
last_name: Kerutt
- first_name: A
full_name: Verhamme, A
last_name: Verhamme
- first_name: P A
full_name: Oesch, P A
last_name: Oesch
- first_name: L
full_name: Barrufet, L
last_name: Barrufet
- first_name: Jorryt J
full_name: Matthee, Jorryt J
id: 7439a258-f3c0-11ec-9501-9df22fe06720
last_name: Matthee
orcid: 0000-0003-2871-127X
- first_name: H
full_name: Kusakabe, H
last_name: Kusakabe
- first_name: I
full_name: Goovaerts, I
last_name: Goovaerts
- first_name: T T
full_name: Thai, T T
last_name: Thai
citation:
ama: Kramarenko I, Kerutt J, Verhamme A, et al. Linking UV spectral properties of
MUSE Ly α emitters at z ≳ 3 to Lyman continuum escape. Monthly Notices
of the Royal Astronomical Society. 2024;527(4):9853-9871. doi:10.1093/mnras/stad3853
apa: Kramarenko, I., Kerutt, J., Verhamme, A., Oesch, P. A., Barrufet, L., Matthee,
J. J., … Thai, T. T. (2024). Linking UV spectral properties of MUSE Ly α emitters
at z ≳ 3 to Lyman continuum escape. Monthly Notices of the Royal Astronomical
Society. Oxford University Press. https://doi.org/10.1093/mnras/stad3853
chicago: Kramarenko, Ivan, J Kerutt, A Verhamme, P A Oesch, L Barrufet, Jorryt J
Matthee, H Kusakabe, I Goovaerts, and T T Thai. “Linking UV Spectral Properties
of MUSE Ly α Emitters at z ≳ 3 to Lyman Continuum Escape.” Monthly Notices
of the Royal Astronomical Society. Oxford University Press, 2024. https://doi.org/10.1093/mnras/stad3853.
ieee: I. Kramarenko et al., “Linking UV spectral properties of MUSE Ly α
emitters at z ≳ 3 to Lyman continuum escape,” Monthly Notices of the
Royal Astronomical Society, vol. 527, no. 4. Oxford University Press, pp.
9853–9871, 2024.
ista: Kramarenko I, Kerutt J, Verhamme A, Oesch PA, Barrufet L, Matthee JJ, Kusakabe
H, Goovaerts I, Thai TT. 2024. Linking UV spectral properties of MUSE Ly α emitters
at z ≳ 3 to Lyman continuum escape. Monthly Notices of the Royal Astronomical
Society. 527(4), 9853–9871.
mla: Kramarenko, Ivan, et al. “Linking UV Spectral Properties of MUSE Ly α Emitters
at z ≳ 3 to Lyman Continuum Escape.” Monthly Notices of the Royal Astronomical
Society, vol. 527, no. 4, Oxford University Press, 2024, pp. 9853–71, doi:10.1093/mnras/stad3853.
short: I. Kramarenko, J. Kerutt, A. Verhamme, P.A. Oesch, L. Barrufet, J.J. Matthee,
H. Kusakabe, I. Goovaerts, T.T. Thai, Monthly Notices of the Royal Astronomical
Society 527 (2024) 9853–9871.
date_created: 2024-01-22T08:22:17Z
date_published: 2024-02-01T00:00:00Z
date_updated: 2024-01-23T12:33:50Z
day: '01'
ddc:
- '520'
department:
- _id: GradSch
- _id: JoMa
doi: 10.1093/mnras/stad3853
external_id:
arxiv:
- '2305.07044'
file:
- access_level: open_access
checksum: 9d02df4035c4951cf63dee0db1e462e9
content_type: application/pdf
creator: dernst
date_created: 2024-01-23T12:30:45Z
date_updated: 2024-01-23T12:30:45Z
file_id: '14879'
file_name: 2024_MNAstronomSoc_Kramarenko.pdf
file_size: 4521738
relation: main_file
success: 1
file_date_updated: 2024-01-23T12:30:45Z
has_accepted_license: '1'
intvolume: ' 527'
issue: '4'
keyword:
- Space and Planetary Science
- Astronomy and Astrophysics
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: 9853-9871
publication: Monthly Notices of the Royal Astronomical Society
publication_identifier:
eissn:
- 1365-2966
issn:
- 0035-8711
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
status: public
title: Linking UV spectral properties of MUSE Ly α emitters at z ≳ 3 to Lyman
continuum escape
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 527
year: '2024'
...
---
_id: '14711'
abstract:
- lang: eng
text: "In nature, different species find their niche in a range of environments,
each with its unique characteristics. While some thrive in uniform (homogeneous)
landscapes where environmental conditions stay relatively consistent across space,
others traverse the complexities of spatially heterogeneous terrains. Comprehending
how species are distributed and how they interact within these landscapes holds
the key to gaining insights into their evolutionary dynamics while also informing
conservation and management strategies.\r\n\r\nFor species inhabiting heterogeneous
landscapes, when the rate of dispersal is low compared to spatial fluctuations
in selection pressure, localized adaptations may emerge. Such adaptation in response
to varying selection strengths plays an important role in the persistence of populations
in our rapidly changing world. Hence, species in nature are continuously in a
struggle to adapt to local environmental conditions, to ensure their continued
survival. Natural populations can often adapt in time scales short enough for
evolutionary changes to influence ecological dynamics and vice versa, thereby
creating a feedback between evolution and demography. The analysis of this feedback
and the relative contributions of gene flow, demography, drift, and natural selection
to genetic variation and differentiation has remained a recurring theme in evolutionary
biology. Nevertheless, the effective role of these forces in maintaining variation
and shaping patterns of diversity is not fully understood. Even in homogeneous
environments devoid of local adaptations, such understanding remains elusive.
Understanding this feedback is crucial, for example in determining the conditions
under which extinction risk can be mitigated in peripheral populations subject
to deleterious mutation accumulation at the edges of species’ ranges\r\nas well
as in highly fragmented populations.\r\n\r\nIn this thesis we explore both uniform
and spatially heterogeneous metapopulations, investigating and providing theoretical
insights into the dynamics of local adaptation in the latter and examining the
dynamics of load and extinction as well as the impact of joint ecological and
evolutionary (eco-evolutionary) dynamics in the former. The thesis is divided
into 5 chapters.\r\n\r\nChapter 1 provides a general introduction into the subject
matter, clarifying concepts and ideas used throughout the thesis. In chapter 2,
we explore how fast a species distributed across a heterogeneous landscape adapts
to changing conditions marked by alterations in carrying capacity, selection pressure,
and migration rate.\r\n\r\nIn chapter 3, we investigate how migration selection
and drift influences adaptation and the maintenance of variation in a metapopulation
with three habitats, an extension of previous models of adaptation in two habitats.
We further develop analytical approximations for the critical threshold required
for polymorphism to persist.\r\n\r\nThe focus of chapter 4 of the thesis is on
understanding the interplay between ecology and evolution as coupled processes.
We investigate how eco-evolutionary feedback between migration, selection, drift,
and demography influences eco-evolutionary outcomes in marginal populations subject
to deleterious mutation accumulation. Using simulations as well as theoretical
approximations of the coupled dynamics of population size and allele frequency,
we analyze how gene flow from a large mainland source influences genetic load
and population size on an island (i.e., in a marginal population) under genetically
realistic assumptions. Analyses of this sort are important because small isolated
populations, are repeatedly affected by complex interactions between ecological
and evolutionary processes, which can lead to their death. Understanding these
interactions can therefore provide an insight into the conditions under which
extinction risk can be mitigated in peripheral populations thus, contributing
to conservation and restoration efforts.\r\n\r\nChapter 5 extends the analysis
in chapter 4 to consider the dynamics of load (due to deleterious mutation accumulation)
and extinction risk in a metapopulation. We explore the role of gene flow, selection,
and dominance on load and extinction risk and further pinpoint critical thresholds
required for metapopulation persistence.\r\n\r\nOverall this research contributes
to our understanding of ecological and evolutionary mechanisms that shape species’
persistence in fragmented landscapes, a crucial foundation for successful conservation
efforts and biodiversity management."
acknowledged_ssus:
- _id: SSU
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Oluwafunmilola O
full_name: Olusanya, Oluwafunmilola O
id: 41AD96DC-F248-11E8-B48F-1D18A9856A87
last_name: Olusanya
orcid: 0000-0003-1971-8314
citation:
ama: Olusanya OO. Local adaptation, genetic load and extinction in metapopulations.
2024. doi:10.15479/at:ista:14711
apa: Olusanya, O. O. (2024). Local adaptation, genetic load and extinction in
metapopulations. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14711
chicago: Olusanya, Oluwafunmilola O. “Local Adaptation, Genetic Load and Extinction
in Metapopulations.” Institute of Science and Technology Austria, 2024. https://doi.org/10.15479/at:ista:14711.
ieee: O. O. Olusanya, “Local adaptation, genetic load and extinction in metapopulations,”
Institute of Science and Technology Austria, 2024.
ista: Olusanya OO. 2024. Local adaptation, genetic load and extinction in metapopulations.
Institute of Science and Technology Austria.
mla: Olusanya, Oluwafunmilola O. Local Adaptation, Genetic Load and Extinction
in Metapopulations. Institute of Science and Technology Austria, 2024, doi:10.15479/at:ista:14711.
short: O.O. Olusanya, Local Adaptation, Genetic Load and Extinction in Metapopulations,
Institute of Science and Technology Austria, 2024.
date_created: 2023-12-26T22:49:53Z
date_published: 2024-01-19T00:00:00Z
date_updated: 2024-01-26T12:00:54Z
day: '19'
ddc:
- '576'
degree_awarded: PhD
department:
- _id: NiBa
- _id: GradSch
doi: 10.15479/at:ista:14711
ec_funded: 1
file:
- access_level: closed
checksum: de179b1c6758f182ff0c70d8b38c1501
content_type: application/zip
creator: oolusany
date_created: 2024-01-03T18:30:13Z
date_updated: 2024-01-03T18:30:13Z
file_id: '14730'
file_name: FinalSubmission_Thesis_OLUSANYA.zip
file_size: 16986244
relation: source_file
- access_level: open_access
checksum: 0e331585e3cd4823320aab4e69e64ccf
content_type: application/pdf
creator: oolusany
date_created: 2024-01-03T18:31:34Z
date_updated: 2024-01-03T18:31:34Z
file_id: '14731'
file_name: FinalSubmission2_Thesis_OLUSANYA.pdf
file_size: 6460403
relation: main_file
success: 1
file_date_updated: 2024-01-03T18:31:34Z
has_accepted_license: '1'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '01'
oa: 1
oa_version: Published Version
page: '183'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: c08d3278-5a5b-11eb-8a69-fdb09b55f4b8
grant_number: P32896
name: Causes and consequences of population fragmentation
- _id: 34c872fe-11ca-11ed-8bc3-8534b82131e6
grant_number: '26380'
name: Polygenic Adaptation in a Metapopulation
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '10658'
relation: part_of_dissertation
status: public
- id: '10787'
relation: part_of_dissertation
status: public
- id: '14732'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Jitka
full_name: Polechova, Jitka
last_name: Polechova
- first_name: Himani
full_name: Sachdeva, Himani
last_name: Sachdeva
title: Local adaptation, genetic load and extinction in metapopulations
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2024'
...
---
_id: '14821'
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Heloisa
full_name: Chiossi, Heloisa
id: 2BBA502C-F248-11E8-B48F-1D18A9856A87
last_name: Chiossi
citation:
ama: Chiossi HSC. Adaptive hierarchical representations in the hippocampus. 2024.
doi:10.15479/at:ista:14821
apa: Chiossi, H. S. C. (2024). Adaptive hierarchical representations in the hippocampus.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14821
chicago: Chiossi, Heloisa S. C. “Adaptive Hierarchical Representations in the Hippocampus.”
Institute of Science and Technology Austria, 2024. https://doi.org/10.15479/at:ista:14821.
ieee: H. S. C. Chiossi, “Adaptive hierarchical representations in the hippocampus,”
Institute of Science and Technology Austria, 2024.
ista: Chiossi HSC. 2024. Adaptive hierarchical representations in the hippocampus.
Institute of Science and Technology Austria.
mla: Chiossi, Heloisa S. C. Adaptive Hierarchical Representations in the Hippocampus.
Institute of Science and Technology Austria, 2024, doi:10.15479/at:ista:14821.
short: H.S.C. Chiossi, Adaptive Hierarchical Representations in the Hippocampus,
Institute of Science and Technology Austria, 2024.
date_created: 2024-01-16T14:25:21Z
date_published: 2024-01-19T00:00:00Z
date_updated: 2024-02-01T09:50:29Z
day: '19'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JoCs
doi: 10.15479/at:ista:14821
ec_funded: 1
file:
- access_level: closed
checksum: d3fa3de1abd5af5204c13e9d55375615
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: hchiossi
date_created: 2024-01-19T11:04:05Z
date_updated: 2024-01-19T11:04:05Z
file_id: '14838'
file_name: PhD_Thesis_190124.docx
file_size: 8656268
relation: source_file
- access_level: closed
checksum: 13adc8dcfb5b6b18107f89f0a98fa8bd
content_type: application/pdf
creator: hchiossi
date_created: 2024-01-19T11:03:59Z
date_updated: 2024-01-19T11:03:59Z
embargo: 2025-01-19
embargo_to: open_access
file_id: '14839'
file_name: PhD_Thesis_190124.pdf
file_size: 6567275
relation: main_file
file_date_updated: 2024-01-19T11:04:05Z
has_accepted_license: '1'
language:
- iso: eng
month: '01'
oa_version: Published Version
page: '89'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
title: Adaptive hierarchical representations in the hippocampus
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2024'
...
---
_id: '14901'
abstract:
- lang: eng
text: Global services like navigation, communication, and Earth observation have
increased dramatically in the 21st century due to advances in outer space industries.
But as orbits become increasingly crowded with both satellites and inevitable
space debris pollution, continued operations become endangered by the heightened
risks of debris collisions in orbit. Kessler Syndrome is the term for when a critical
threshold of orbiting debris triggers a runaway positive feedback loop of debris
collisions, creating debris congestion that can render orbits unusable. As this
potential tipping point becomes more widely recognized, there have been renewed
calls for debris mitigation and removal. Here, we combine complex systems and
social-ecological systems approaches to study how these efforts may affect space
debris accumulation and the likelihood of reaching Kessler Syndrome. Specifically,
we model how debris levels are affected by future launch rates, cleanup activities,
and collisions between extant debris. We contextualize and interpret our dynamic
model within a discussion of existing space debris governance and other social,
economic, and geopolitical factors that may influence effective collective management
of the orbital commons. In line with previous studies, our model finds that debris
congestion may be reached in less than 200 years, though a holistic management
strategy combining removal and mitigation actions can avoid such outcomes while
continuing space activities. Moreover, although active debris removal may be particularly
effective, the current lack of market and governance support may impede its implementation.
Research into these critical dynamics and the multi-faceted variables that influence
debris outcomes can support policymakers in curating impactful governance strategies
and realistic transition pathways to sustaining debris-free orbits. Overall, our
study is useful for communicating about space debris sustainability in policy
and education settings by providing an exploration of policy portfolio options
supported by a simple and clear social-ecological modeling approach.
acknowledgement: The authors would like to thank the special issue co-editors, Marco
Janssen and Xiao-Shan Yap, and the anonymous reviewers for their comments that helped
improve the manuscript. The paper also benefited from suggestions by other author
participants in this special issue. We would also like to thank the 2022 Santa Fe
Institute Complex Systems Summer School for providing space to initiate this study.
article_processing_charge: Yes
article_type: original
author:
- first_name: Keiko
full_name: Nomura, Keiko
last_name: Nomura
- first_name: Simon
full_name: Rella, Simon
id: B4765ACA-AA38-11E9-AC9A-0930E6697425
last_name: Rella
- first_name: Haily
full_name: Merritt, Haily
last_name: Merritt
- first_name: Mathieu
full_name: Baltussen, Mathieu
last_name: Baltussen
- first_name: Darcy
full_name: Bird, Darcy
last_name: Bird
- first_name: Annika
full_name: Tjuka, Annika
last_name: Tjuka
- first_name: Dan
full_name: Falk, Dan
last_name: Falk
citation:
ama: Nomura K, Rella S, Merritt H, et al. Tipping points of space debris in low
earth orbit. International Journal of the Commons. 2024;18(1). doi:10.5334/ijc.1275
apa: Nomura, K., Rella, S., Merritt, H., Baltussen, M., Bird, D., Tjuka, A., &
Falk, D. (2024). Tipping points of space debris in low earth orbit. International
Journal of the Commons. Ubiquity Press. https://doi.org/10.5334/ijc.1275
chicago: Nomura, Keiko, Simon Rella, Haily Merritt, Mathieu Baltussen, Darcy Bird,
Annika Tjuka, and Dan Falk. “Tipping Points of Space Debris in Low Earth Orbit.”
International Journal of the Commons. Ubiquity Press, 2024. https://doi.org/10.5334/ijc.1275.
ieee: K. Nomura et al., “Tipping points of space debris in low earth orbit,”
International Journal of the Commons, vol. 18, no. 1. Ubiquity Press, 2024.
ista: Nomura K, Rella S, Merritt H, Baltussen M, Bird D, Tjuka A, Falk D. 2024.
Tipping points of space debris in low earth orbit. International Journal of the
Commons. 18(1).
mla: Nomura, Keiko, et al. “Tipping Points of Space Debris in Low Earth Orbit.”
International Journal of the Commons, vol. 18, no. 1, Ubiquity Press, 2024,
doi:10.5334/ijc.1275.
short: K. Nomura, S. Rella, H. Merritt, M. Baltussen, D. Bird, A. Tjuka, D. Falk,
International Journal of the Commons 18 (2024).
date_created: 2024-01-30T11:58:02Z
date_published: 2024-01-11T00:00:00Z
date_updated: 2024-02-05T10:10:27Z
day: '11'
ddc:
- '550'
department:
- _id: GradSch
- _id: GaTk
doi: 10.5334/ijc.1275
file:
- access_level: open_access
checksum: b80ebc889033c365d8f8c05a0c655382
content_type: application/pdf
creator: dernst
date_created: 2024-02-05T10:06:35Z
date_updated: 2024-02-05T10:06:35Z
file_id: '14939'
file_name: 2023_IntJourCommons_Nomura.pdf
file_size: 1305786
relation: main_file
success: 1
file_date_updated: 2024-02-05T10:06:35Z
has_accepted_license: '1'
intvolume: ' 18'
issue: '1'
keyword:
- Sociology and Political Science
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
publication: International Journal of the Commons
publication_identifier:
issn:
- 1875-0281
publication_status: published
publisher: Ubiquity Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Tipping points of space debris in low earth orbit
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2024'
...
---
_id: '14705'
abstract:
- lang: eng
text: Since the commercialization of brine shrimp (genus Artemia) in the 1950s,
this lineage, and in particular the model species Artemia franciscana, has been
the subject of extensive research. However, our understanding of the genetic mechanisms
underlying various aspects of their reproductive biology, including sex determination,
are still lacking. This is partly due to the scarcity of genomic resources for
Artemia species and crustaceans in general. Here, we present a chromosome-level
genome assembly of Artemia franciscana (Kellogg 1906), from the Great Salt Lake,
USA. The genome is 1GB, and the majority of the genome (81%) is scaffolded into
21 linkage groups using a previously published high-density linkage map. We performed
coverage and FST analyses using male and female genomic and transcriptomic reads
to quantify the extent of differentiation between the Z and W chromosomes. Additionally,
we quantified the expression levels in male and female heads and gonads and found
further evidence for dosage compensation in this species.
article_processing_charge: No
author:
- first_name: Marwan N
full_name: Elkrewi, Marwan N
id: 0B46FACA-A8E1-11E9-9BD3-79D1E5697425
last_name: Elkrewi
orcid: 0000-0002-5328-7231
citation:
ama: Elkrewi MN. Data from “Chromosome-level assembly of Artemia franciscana sheds
light on sex-chromosome differentiation.” 2024. doi:10.15479/AT:ISTA:14705
apa: Elkrewi, M. N. (2024). Data from “Chromosome-level assembly of Artemia franciscana
sheds light on sex-chromosome differentiation.” Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:14705
chicago: Elkrewi, Marwan N. “Data from ‘Chromosome-Level Assembly of Artemia Franciscana
Sheds Light on Sex-Chromosome Differentiation.’” Institute of Science and Technology
Austria, 2024. https://doi.org/10.15479/AT:ISTA:14705.
ieee: M. N. Elkrewi, “Data from ‘Chromosome-level assembly of Artemia franciscana
sheds light on sex-chromosome differentiation.’” Institute of Science and Technology
Austria, 2024.
ista: Elkrewi MN. 2024. Data from ‘Chromosome-level assembly of Artemia franciscana
sheds light on sex-chromosome differentiation’, Institute of Science and Technology
Austria, 10.15479/AT:ISTA:14705.
mla: Elkrewi, Marwan N. Data from “Chromosome-Level Assembly of Artemia Franciscana
Sheds Light on Sex-Chromosome Differentiation.” Institute of Science and Technology
Austria, 2024, doi:10.15479/AT:ISTA:14705.
short: M.N. Elkrewi, (2024).
contributor:
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first_name: Vincent K
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last_name: Bett
- contributor_type: project_member
first_name: Ariana
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last_name: Macon
- contributor_type: supervisor
first_name: Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
- contributor_type: researcher
first_name: Marwan N
id: 0B46FACA-A8E1-11E9-9BD3-79D1E5697425
last_name: Elkrewi
orcid: 0000-0002-5328-7231
date_created: 2023-12-22T13:40:48Z
date_published: 2024-01-02T00:00:00Z
date_updated: 2024-02-26T09:59:29Z
day: '02'
ddc:
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- _id: BeVi
doi: 10.15479/AT:ISTA:14705
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keyword:
- sex chromosome evolution
- genome assembly
- dosage compensation
month: '01'
oa: 1
oa_version: Published Version
project:
- _id: 34ae1506-11ca-11ed-8bc3-c14f4c474396
grant_number: F8810
name: The highjacking of meiosis for asexual reproduction
publisher: Institute of Science and Technology Austria
related_material:
record:
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relation: used_in_publication
status: public
status: public
title: Data from "Chromosome-level assembly of Artemia franciscana sheds light on
sex-chromosome differentiation"
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2024'
...
---
_id: '14796'
abstract:
- lang: eng
text: Key innovations are fundamental to biological diversification, but their genetic
basis is poorly understood. A recent transition from egg-laying to live-bearing
in marine snails (Littorina spp.) provides the opportunity to study the genetic
architecture of an innovation that has evolved repeatedly across animals. Individuals
do not cluster by reproductive mode in a genome-wide phylogeny, but local genealogical
analysis revealed numerous small genomic regions where all live-bearers carry
the same core haplotype. Candidate regions show evidence for live-bearer–specific
positive selection and are enriched for genes that are differentially expressed
between egg-laying and live-bearing reproductive systems. Ages of selective sweeps
suggest that live-bearer–specific alleles accumulated over more than 200,000 generations.
Our results suggest that new functions evolve through the recruitment of many
alleles rather than in a single evolutionary step.
acknowledgement: "We thank J. Galindo, M. Montaño-Rendón, N. Mikhailova, A. Blakeslee,
E. Arnason, and P. Kemppainen for providing samples; R. Turney, G. Sotelo, J. Larsson,
T. Broquet, and S. Loisel for help collecting samples; Science Animated for providing
the snail cartoons shown in Fig. 1; M. Dunning for help in developing bioinformatic
pipelines; R. Faria, H. Morales, and V. Sousa for advice; and M. Hahn, J. Slate,
M. Ravinet, J. Raeymaekers, A. Comeault, and N. Barton for feedback on a draft manuscript.\r\nThis
work was supported by the Natural Environment Research Council (grant NE/P001610/1
to R.K.B.), the European Research Council (grant ERC-2015-AdG693030-BARRIERS to
R.K.B.), the Norwegian Research Council (RCN Project 315287 to A.M.W.), and the
Swedish Research Council (grant 2020-05385 to E.L.)."
article_processing_charge: No
article_type: original
author:
- first_name: Sean
full_name: Stankowski, Sean
id: 43161670-5719-11EA-8025-FABC3DDC885E
last_name: Stankowski
- first_name: Zuzanna B.
full_name: Zagrodzka, Zuzanna B.
last_name: Zagrodzka
- first_name: Martin D.
full_name: Garlovsky, Martin D.
last_name: Garlovsky
- first_name: Arka
full_name: Pal, Arka
id: 6AAB2240-CA9A-11E9-9C1A-D9D1E5697425
last_name: Pal
orcid: 0000-0002-4530-8469
- first_name: Daria
full_name: Shipilina, Daria
id: 428A94B0-F248-11E8-B48F-1D18A9856A87
last_name: Shipilina
orcid: 0000-0002-1145-9226
- first_name: Diego Fernando
full_name: Garcia Castillo, Diego Fernando
id: ae681a14-dc74-11ea-a0a7-c6ef18161701
last_name: Garcia Castillo
- first_name: Hila
full_name: Lifchitz, Hila
id: d6ab5470-2fb3-11ed-8633-986a9b84edac
last_name: Lifchitz
- first_name: Alan
full_name: Le Moan, Alan
last_name: Le Moan
- first_name: Erica
full_name: Leder, Erica
last_name: Leder
- first_name: James
full_name: Reeve, James
last_name: Reeve
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Roger K.
full_name: Butlin, Roger K.
last_name: Butlin
citation:
ama: Stankowski S, Zagrodzka ZB, Garlovsky MD, et al. The genetic basis of a recent
transition to live-bearing in marine snails. Science. 2024;383(6678):114-119.
doi:10.1126/science.adi2982
apa: Stankowski, S., Zagrodzka, Z. B., Garlovsky, M. D., Pal, A., Shipilina, D.,
Garcia Castillo, D. F., … Butlin, R. K. (2024). The genetic basis of a recent
transition to live-bearing in marine snails. Science. American Association
for the Advancement of Science. https://doi.org/10.1126/science.adi2982
chicago: Stankowski, Sean, Zuzanna B. Zagrodzka, Martin D. Garlovsky, Arka Pal,
Daria Shipilina, Diego Fernando Garcia Castillo, Hila Lifchitz, et al. “The Genetic
Basis of a Recent Transition to Live-Bearing in Marine Snails.” Science.
American Association for the Advancement of Science, 2024. https://doi.org/10.1126/science.adi2982.
ieee: S. Stankowski et al., “The genetic basis of a recent transition to
live-bearing in marine snails,” Science, vol. 383, no. 6678. American Association
for the Advancement of Science, pp. 114–119, 2024.
ista: Stankowski S, Zagrodzka ZB, Garlovsky MD, Pal A, Shipilina D, Garcia Castillo
DF, Lifchitz H, Le Moan A, Leder E, Reeve J, Johannesson K, Westram AM, Butlin
RK. 2024. The genetic basis of a recent transition to live-bearing in marine snails.
Science. 383(6678), 114–119.
mla: Stankowski, Sean, et al. “The Genetic Basis of a Recent Transition to Live-Bearing
in Marine Snails.” Science, vol. 383, no. 6678, American Association for
the Advancement of Science, 2024, pp. 114–19, doi:10.1126/science.adi2982.
short: S. Stankowski, Z.B. Zagrodzka, M.D. Garlovsky, A. Pal, D. Shipilina, D.F.
Garcia Castillo, H. Lifchitz, A. Le Moan, E. Leder, J. Reeve, K. Johannesson,
A.M. Westram, R.K. Butlin, Science 383 (2024) 114–119.
date_created: 2024-01-14T23:00:56Z
date_published: 2024-01-05T00:00:00Z
date_updated: 2024-03-05T09:35:25Z
day: '05'
department:
- _id: NiBa
- _id: GradSch
doi: 10.1126/science.adi2982
external_id:
pmid:
- '38175895'
intvolume: ' 383'
issue: '6678'
language:
- iso: eng
month: '01'
oa_version: None
page: 114-119
pmid: 1
publication: Science
publication_identifier:
eissn:
- 1095-9203
publication_status: published
publisher: American Association for the Advancement of Science
quality_controlled: '1'
related_material:
link:
- description: News on ISTA Website
relation: press_release
url: https://ista.ac.at/en/news/the-snail-or-the-egg/
record:
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relation: research_data
status: public
scopus_import: '1'
status: public
title: The genetic basis of a recent transition to live-bearing in marine snails
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 383
year: '2024'
...
---
_id: '15020'
abstract:
- lang: eng
text: "This thesis consists of four distinct pieces of work within theoretical biology,
with two themes in common: the concept of optimization in biological systems,
and the use of information-theoretic tools to quantify biological stochasticity
and statistical uncertainty.\r\nChapter 2 develops a statistical framework for
studying biological systems which we believe to be optimized for a particular
utility function, such as retinal neurons conveying information about visual stimuli.
We formalize such beliefs as maximum-entropy Bayesian priors, constrained by the
expected utility. We explore how such priors aid inference of system parameters
with limited data and enable optimality hypothesis testing: is the utility higher
than by chance?\r\nChapter 3 examines the ultimate biological optimization process:
evolution by natural selection. As some individuals survive and reproduce more
successfully than others, populations evolve towards fitter genotypes and phenotypes.
We formalize this as accumulation of genetic information, and use population genetics
theory to study how much such information can be accumulated per generation and
maintained in the face of random mutation and genetic drift. We identify the population
size and fitness variance as the key quantities that control information accumulation
and maintenance.\r\nChapter 4 reuses the concept of genetic information from Chapter
3, but from a different perspective: we ask how much genetic information organisms
actually need, in particular in the context of gene regulation. For example, how
much information is needed to bind transcription factors at correct locations
within the genome? Population genetics provides us with a refined answer: with
an increasing population size, populations achieve higher fitness by maintaining
more genetic information. Moreover, regulatory parameters experience selection
pressure to optimize the fitness-information trade-off, i.e. minimize the information
needed for a given fitness. This provides an evolutionary derivation of the optimization
priors introduced in Chapter 2.\r\nChapter 5 proves an upper bound on mutual information
between a signal and a communication channel output (such as neural activity).
Mutual information is an important utility measure for biological systems, but
its practical use can be difficult due to the large dimensionality of many biological
channels. Sometimes, a lower bound on mutual information is computed by replacing
the high-dimensional channel outputs with decodes (signal estimates). Our result
provides a corresponding upper bound, provided that the decodes are the maximum
posterior estimates of the signal."
acknowledged_ssus:
- _id: ScienComp
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Michal
full_name: Hledik, Michal
id: 4171253A-F248-11E8-B48F-1D18A9856A87
last_name: Hledik
citation:
ama: Hledik M. Genetic information and biological optimization. 2024. doi:10.15479/at:ista:15020
apa: Hledik, M. (2024). Genetic information and biological optimization.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:15020
chicago: Hledik, Michal. “Genetic Information and Biological Optimization.” Institute
of Science and Technology Austria, 2024. https://doi.org/10.15479/at:ista:15020.
ieee: M. Hledik, “Genetic information and biological optimization,” Institute of
Science and Technology Austria, 2024.
ista: Hledik M. 2024. Genetic information and biological optimization. Institute
of Science and Technology Austria.
mla: Hledik, Michal. Genetic Information and Biological Optimization. Institute
of Science and Technology Austria, 2024, doi:10.15479/at:ista:15020.
short: M. Hledik, Genetic Information and Biological Optimization, Institute of
Science and Technology Austria, 2024.
date_created: 2024-02-23T14:02:04Z
date_published: 2024-02-23T00:00:00Z
date_updated: 2024-03-06T14:22:52Z
day: '23'
ddc:
- '576'
- '519'
degree_awarded: PhD
department:
- _id: GradSch
- _id: NiBa
- _id: GaTk
doi: 10.15479/at:ista:15020
ec_funded: 1
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keyword:
- Theoretical biology
- Optimality
- Evolution
- Information
language:
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oa: 1
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call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
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grant_number: RGP0034/2018
name: Can evolution minimize spurious signaling crosstalk to reach optimal performance?
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name: Understanding the evolution of continuous genomes
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
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relation: part_of_dissertation
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status: public
status: public
supervisor:
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full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
title: Genetic information and biological optimization
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2024'
...
---
_id: '15101'
acknowledged_ssus:
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alternative_title:
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article_processing_charge: No
author:
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full_name: Chen, JingJing
id: 2C4E65C8-F248-11E8-B48F-1D18A9856A87
last_name: Chen
citation:
ama: Chen J. Developmental transformation of nanodomain coupling between Ca2+ channels
and release sensors at a central GABAergic synapse. 2024. doi:10.15479/at:ista:15101
apa: Chen, J. (2024). Developmental transformation of nanodomain coupling between
Ca2+ channels and release sensors at a central GABAergic synapse. Institute
of Science and Technology Austria. https://doi.org/10.15479/at:ista:15101
chicago: Chen, JingJing. “Developmental Transformation of Nanodomain Coupling between
Ca2+ Channels and Release Sensors at a Central GABAergic Synapse.” Institute of
Science and Technology Austria, 2024. https://doi.org/10.15479/at:ista:15101.
ieee: J. Chen, “Developmental transformation of nanodomain coupling between Ca2+
channels and release sensors at a central GABAergic synapse,” Institute of Science
and Technology Austria, 2024.
ista: Chen J. 2024. Developmental transformation of nanodomain coupling between
Ca2+ channels and release sensors at a central GABAergic synapse. Institute of
Science and Technology Austria.
mla: Chen, JingJing. Developmental Transformation of Nanodomain Coupling between
Ca2+ Channels and Release Sensors at a Central GABAergic Synapse. Institute
of Science and Technology Austria, 2024, doi:10.15479/at:ista:15101.
short: J. Chen, Developmental Transformation of Nanodomain Coupling between Ca2+
Channels and Release Sensors at a Central GABAergic Synapse, Institute of Science
and Technology Austria, 2024.
date_created: 2024-03-11T10:09:54Z
date_published: 2024-03-11T00:00:00Z
date_updated: 2024-03-14T13:14:19Z
day: '11'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: PeJo
doi: 10.15479/at:ista:15101
ec_funded: 1
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date_updated: 2024-03-11T14:11:06Z
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embargo_to: open_access
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file_name: Thesis_Jingjing CHEN_merged.pdf
file_size: 16627311
relation: main_file
file_date_updated: 2024-03-12T07:12:17Z
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language:
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month: '03'
oa_version: Published Version
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project:
- _id: 25B7EB9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '692692'
name: Biophysics and circuit function of a giant cortical glumatergic synapse
- _id: 25C5A090-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00312
name: The Wittgenstein Prize
- _id: bd88be38-d553-11ed-ba76-81d5a70a6ef5
grant_number: P36232
name: Mechanisms of GABA release in hippocampal circuits
- _id: 26B66A3E-B435-11E9-9278-68D0E5697425
grant_number: '25383'
name: Development of nanodomain coupling between Ca2+ channels and release sensors
at a central inhibitory synapse
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '14843'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Peter M
full_name: Jonas, Peter M
id: 353C1B58-F248-11E8-B48F-1D18A9856A87
last_name: Jonas
orcid: 0000-0001-5001-4804
title: Developmental transformation of nanodomain coupling between Ca2+ channels and
release sensors at a central GABAergic synapse
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2024'
...
---
_id: '10045'
abstract:
- lang: eng
text: "Given a fixed finite metric space (V,μ), the {\\em minimum 0-extension problem},
denoted as 0-Ext[μ], is equivalent to the following optimization problem: minimize
function of the form minx∈Vn∑ifi(xi)+∑ijcijμ(xi,xj) where cij,cvi are given nonnegative
costs and fi:V→R are functions given by fi(xi)=∑v∈Vcviμ(xi,v). The computational
complexity of 0-Ext[μ] has been recently established by Karzanov and by Hirai:
if metric μ is {\\em orientable modular} then 0-Ext[μ] can be solved in polynomial
time, otherwise 0-Ext[μ] is NP-hard. To prove the tractability part, Hirai developed
a theory of discrete convex functions on orientable modular graphs generalizing
several known classes of functions in discrete convex analysis, such as L♮-convex
functions. We consider a more general version of the problem in which unary functions
fi(xi) can additionally have terms of the form cuv;iμ(xi,{u,v}) for {u,v}∈F, where
set F⊆(V2) is fixed. We extend the complexity classification above by providing
an explicit condition on (μ,F) for the problem to be tractable. In order to prove
the tractability part, we generalize Hirai's theory and define a larger class
of discrete convex functions. It covers, in particular, another well-known class
of functions, namely submodular functions on an integer lattice. Finally, we improve
the complexity of Hirai's algorithm for solving 0-Ext on orientable modular graphs.\r\n"
acknowledgement: We thank the anonymous reviewers for their careful reading of our
manuscript and their many insightful comments and suggestions. Open access funding
provided by Institute of Science and Technology (IST Austria).
article_number: '2109.10203'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Martin
full_name: Dvorak, Martin
id: 40ED02A8-C8B4-11E9-A9C0-453BE6697425
last_name: Dvorak
orcid: 0000-0001-5293-214X
- first_name: Vladimir
full_name: Kolmogorov, Vladimir
id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
last_name: Kolmogorov
citation:
ama: Dvorak M, Kolmogorov V. Generalized minimum 0-extension problem and discrete
convexity. Mathematical Programming. 2024. doi:10.1007/s10107-024-02064-5
apa: Dvorak, M., & Kolmogorov, V. (2024). Generalized minimum 0-extension problem
and discrete convexity. Mathematical Programming. Springer Nature. https://doi.org/10.1007/s10107-024-02064-5
chicago: Dvorak, Martin, and Vladimir Kolmogorov. “Generalized Minimum 0-Extension
Problem and Discrete Convexity.” Mathematical Programming. Springer Nature,
2024. https://doi.org/10.1007/s10107-024-02064-5.
ieee: M. Dvorak and V. Kolmogorov, “Generalized minimum 0-extension problem and
discrete convexity,” Mathematical Programming. Springer Nature, 2024.
ista: Dvorak M, Kolmogorov V. 2024. Generalized minimum 0-extension problem and
discrete convexity. Mathematical Programming., 2109.10203.
mla: Dvorak, Martin, and Vladimir Kolmogorov. “Generalized Minimum 0-Extension Problem
and Discrete Convexity.” Mathematical Programming, 2109.10203, Springer
Nature, 2024, doi:10.1007/s10107-024-02064-5.
short: M. Dvorak, V. Kolmogorov, Mathematical Programming (2024).
date_created: 2021-09-27T10:48:23Z
date_published: 2024-03-07T00:00:00Z
date_updated: 2024-03-19T08:20:31Z
day: '07'
ddc:
- '004'
department:
- _id: GradSch
- _id: VlKo
doi: 10.1007/s10107-024-02064-5
external_id:
arxiv:
- '2109.10203'
file:
- access_level: open_access
checksum: e7e83065f7bc18b9c188bf93b5ca5db6
content_type: application/pdf
creator: mdvorak
date_created: 2021-09-27T10:54:51Z
date_updated: 2021-09-27T10:54:51Z
file_id: '10046'
file_name: Generalized-0-Ext.pdf
file_size: 603672
relation: main_file
success: 1
file_date_updated: 2021-09-27T10:54:51Z
has_accepted_license: '1'
keyword:
- minimum 0-extension problem
- metric labeling problem
- discrete metric spaces
- metric extensions
- computational complexity
- valued constraint satisfaction problems
- discrete convex analysis
- L-convex functions
language:
- iso: eng
month: '03'
oa: 1
oa_version: Preprint
publication: Mathematical Programming
publication_identifier:
eissn:
- 1436-4646
issn:
- 0025-5610
publication_status: epub_ahead
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Generalized minimum 0-extension problem and discrete convexity
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2024'
...
---
_id: '15094'
abstract:
- lang: eng
text: "Point sets, geometric networks, and arrangements of hyperplanes are fundamental
objects in\r\ndiscrete geometry that have captivated mathematicians for centuries,
if not millennia. This\r\nthesis seeks to cast new light on these structures by
illustrating specific instances where a\r\ntopological perspective, specifically
through discrete Morse theory and persistent homology,\r\nprovides valuable insights.\r\n\r\nAt
first glance, the topology of these geometric objects might seem uneventful: point
sets\r\nessentially lack of topology, arrangements of hyperplanes are a decomposition
of Rd, which\r\nis a contractible space, and the topology of a network primarily
involves the enumeration\r\nof connected components and cycles within the network.
However, beneath this apparent\r\nsimplicity, there lies an array of intriguing
structures, a small subset of which will be uncovered\r\nin this thesis.\r\n\r\nFocused
on three case studies, each addressing one of the mentioned objects, this work\r\nwill
showcase connections that intertwine topology with diverse fields such as combinatorial\r\ngeometry,
algorithms and data structures, and emerging applications like spatial biology.\r\n\r\n"
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Sebastiano
full_name: Cultrera di Montesano, Sebastiano
id: 34D2A09C-F248-11E8-B48F-1D18A9856A87
last_name: Cultrera di Montesano
orcid: 0000-0001-6249-0832
citation:
ama: Cultrera di Montesano S. Persistence and Morse theory for discrete geometric
structures. 2024. doi:10.15479/at:ista:15094
apa: Cultrera di Montesano, S. (2024). Persistence and Morse theory for discrete
geometric structures. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:15094
chicago: Cultrera di Montesano, Sebastiano. “Persistence and Morse Theory for Discrete
Geometric Structures.” Institute of Science and Technology Austria, 2024. https://doi.org/10.15479/at:ista:15094.
ieee: S. Cultrera di Montesano, “Persistence and Morse theory for discrete geometric
structures,” Institute of Science and Technology Austria, 2024.
ista: Cultrera di Montesano S. 2024. Persistence and Morse theory for discrete geometric
structures. Institute of Science and Technology Austria.
mla: Cultrera di Montesano, Sebastiano. Persistence and Morse Theory for Discrete
Geometric Structures. Institute of Science and Technology Austria, 2024, doi:10.15479/at:ista:15094.
short: S. Cultrera di Montesano, Persistence and Morse Theory for Discrete Geometric
Structures, Institute of Science and Technology Austria, 2024.
date_created: 2024-03-08T15:28:10Z
date_published: 2024-03-08T00:00:00Z
date_updated: 2024-03-20T09:36:57Z
day: '08'
ddc:
- '514'
- '500'
- '516'
degree_awarded: PhD
department:
- _id: GradSch
- _id: HeEd
doi: 10.15479/at:ista:15094
ec_funded: 1
file:
- access_level: open_access
checksum: 1e468bfa42a7dcf04d89f4dadc621c87
content_type: application/pdf
creator: scultrer
date_created: 2024-03-14T08:55:07Z
date_updated: 2024-03-14T08:55:07Z
file_id: '15112'
file_name: Thesis Sebastiano.pdf
file_size: 4106872
relation: main_file
success: 1
- access_level: closed
checksum: bcbd213490f5a7e68855a092bbce93f1
content_type: application/zip
creator: scultrer
date_created: 2024-03-14T08:56:24Z
date_updated: 2024-03-14T14:14:35Z
file_id: '15113'
file_name: Thesis (1).zip
file_size: 4746234
relation: source_file
file_date_updated: 2024-03-14T14:14:35Z
has_accepted_license: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: '108'
project:
- _id: 266A2E9E-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '788183'
name: Alpha Shape Theory Extended
- _id: 268116B8-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z00342
name: The Wittgenstein Prize
- _id: 0aa4bc98-070f-11eb-9043-e6fff9c6a316
grant_number: I4887
name: Discretization in Geometry and Dynamics
- _id: 2561EBF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I02979-N35
name: Persistence and stability of geometric complexes
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '11660'
relation: part_of_dissertation
status: public
- id: '11658'
relation: part_of_dissertation
status: public
- id: '13182'
relation: part_of_dissertation
status: public
- id: '15090'
relation: part_of_dissertation
status: public
- id: '15091'
relation: part_of_dissertation
status: public
- id: '15093'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
title: Persistence and Morse theory for discrete geometric structures
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2024'
...
---
_id: '12676'
abstract:
- lang: eng
text: Turn-based stochastic games (aka simple stochastic games) are two-player zero-sum
games played on directed graphs with probabilistic transitions. The goal of player-max
is to maximize the probability to reach a target state against the adversarial
player-min. These games lie in NP ∩ coNP and are among the rare combinatorial
problems that belong to this complexity class for which the existence of polynomial-time
algorithm is a major open question. While randomized sub-exponential time algorithm
exists, all known deterministic algorithms require exponential time in the worst-case.
An important open question has been whether faster algorithms can be obtained
parametrized by the treewidth of the game graph. Even deterministic sub-exponential
time algorithm for constant treewidth turn-based stochastic games has remain elusive.
In this work our main result is a deterministic algorithm to solve turn-based
stochastic games that, given a game with n states, treewidth at most t, and the
bit-complexity of the probabilistic transition function log D, has running time
O ((tn2 log D)t log n). In particular, our algorithm is quasi-polynomial time
for games with constant or poly-logarithmic treewidth.
acknowledgement: This research was partially supported by the ERC CoG 863818 (ForM-SMArt)
grant.
article_processing_charge: No
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Tobias
full_name: Meggendorfer, Tobias
id: b21b0c15-30a2-11eb-80dc-f13ca25802e1
last_name: Meggendorfer
orcid: 0000-0002-1712-2165
- first_name: Raimundo J
full_name: Saona Urmeneta, Raimundo J
id: BD1DF4C4-D767-11E9-B658-BC13E6697425
last_name: Saona Urmeneta
orcid: 0000-0001-5103-038X
- first_name: Jakub
full_name: Svoboda, Jakub
id: 130759D2-D7DD-11E9-87D2-DE0DE6697425
last_name: Svoboda
citation:
ama: 'Chatterjee K, Meggendorfer T, Saona Urmeneta RJ, Svoboda J. Faster algorithm
for turn-based stochastic games with bounded treewidth. In: Proceedings of
the 2023 Annual ACM-SIAM Symposium on Discrete Algorithms. Society for Industrial
and Applied Mathematics; 2023:4590-4605. doi:10.1137/1.9781611977554.ch173'
apa: 'Chatterjee, K., Meggendorfer, T., Saona Urmeneta, R. J., & Svoboda, J.
(2023). Faster algorithm for turn-based stochastic games with bounded treewidth.
In Proceedings of the 2023 Annual ACM-SIAM Symposium on Discrete Algorithms
(pp. 4590–4605). Florence, Italy: Society for Industrial and Applied Mathematics.
https://doi.org/10.1137/1.9781611977554.ch173'
chicago: Chatterjee, Krishnendu, Tobias Meggendorfer, Raimundo J Saona Urmeneta,
and Jakub Svoboda. “Faster Algorithm for Turn-Based Stochastic Games with Bounded
Treewidth.” In Proceedings of the 2023 Annual ACM-SIAM Symposium on Discrete
Algorithms, 4590–4605. Society for Industrial and Applied Mathematics, 2023.
https://doi.org/10.1137/1.9781611977554.ch173.
ieee: K. Chatterjee, T. Meggendorfer, R. J. Saona Urmeneta, and J. Svoboda, “Faster
algorithm for turn-based stochastic games with bounded treewidth,” in Proceedings
of the 2023 Annual ACM-SIAM Symposium on Discrete Algorithms, Florence, Italy,
2023, pp. 4590–4605.
ista: 'Chatterjee K, Meggendorfer T, Saona Urmeneta RJ, Svoboda J. 2023. Faster
algorithm for turn-based stochastic games with bounded treewidth. Proceedings
of the 2023 Annual ACM-SIAM Symposium on Discrete Algorithms. SODA: Symposium
on Discrete Algorithms, 4590–4605.'
mla: Chatterjee, Krishnendu, et al. “Faster Algorithm for Turn-Based Stochastic
Games with Bounded Treewidth.” Proceedings of the 2023 Annual ACM-SIAM Symposium
on Discrete Algorithms, Society for Industrial and Applied Mathematics, 2023,
pp. 4590–605, doi:10.1137/1.9781611977554.ch173.
short: K. Chatterjee, T. Meggendorfer, R.J. Saona Urmeneta, J. Svoboda, in:, Proceedings
of the 2023 Annual ACM-SIAM Symposium on Discrete Algorithms, Society for Industrial
and Applied Mathematics, 2023, pp. 4590–4605.
conference:
end_date: 2023-01-25
location: Florence, Italy
name: 'SODA: Symposium on Discrete Algorithms'
start_date: 2023-01-22
date_created: 2023-02-24T12:20:47Z
date_published: 2023-02-01T00:00:00Z
date_updated: 2023-02-27T09:01:16Z
day: '01'
department:
- _id: GradSch
- _id: KrCh
doi: 10.1137/1.9781611977554.ch173
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1137/1.9781611977554.ch173
month: '02'
oa: 1
oa_version: Published Version
page: 4590-4605
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '863818'
name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
publication: Proceedings of the 2023 Annual ACM-SIAM Symposium on Discrete Algorithms
publication_identifier:
isbn:
- '9781611977554'
publication_status: published
publisher: Society for Industrial and Applied Mathematics
quality_controlled: '1'
status: public
title: Faster algorithm for turn-based stochastic games with bounded treewidth
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12736'
abstract:
- lang: eng
text: Although a wide variety of handcrafted concurrent data structures have been
proposed, there is considerable interest in universal approaches (Universal Constructions
or UCs) for building concurrent data structures. UCs (semi-)automatically convert
a sequential data structure into a concurrent one. The simplest approach uses
locks [3, 6] that protect a sequential data structure and allow only one process
to access it at a time. However, the resulting data structure is blocking. Most
work on UCs instead focuses on obtaining non-blocking progress guarantees such
as obstruction-freedom, lock-freedom or wait-freedom. Many non-blocking UCs have
appeared. Key examples include the seminal wait-free UC [2] by Herlihy, a NUMA-aware
UC [10] by Yi et al., and an efficient UC for large objects [1] by Fatourou et
al.
acknowledgement: 'This work was supported by: the Natural Sciences and Engineering
Research Council of Canada (NSERC) Discovery Program grant: RGPIN-2019-04227, and
the Canada Foundation for Innovation John R. Evans Leaders Fund (CFI-JELF) with
equal support from the Ontario Research Fund CFI Leaders Opportunity Fund: 38512.'
article_processing_charge: No
author:
- first_name: Vitaly
full_name: Aksenov, Vitaly
last_name: Aksenov
- first_name: Trevor A
full_name: Brown, Trevor A
id: 3569F0A0-F248-11E8-B48F-1D18A9856A87
last_name: Brown
- first_name: Alexander
full_name: Fedorov, Alexander
id: 2e711909-896a-11ed-bdf8-eb0f5a2984c6
last_name: Fedorov
- first_name: Ilya
full_name: Kokorin, Ilya
last_name: Kokorin
citation:
ama: Aksenov V, Brown TA, Fedorov A, Kokorin I. Unexpected Scaling in Path Copying
Trees. Association for Computing Machinery; 2023:438-440. doi:10.1145/3572848.3577512
apa: 'Aksenov, V., Brown, T. A., Fedorov, A., & Kokorin, I. (2023). Unexpected
scaling in path copying trees. Proceedings of the ACM SIGPLAN Symposium
on Principles and Practice of Parallel Programming (pp. 438–440). Montreal,
QB, Canada: Association for Computing Machinery. https://doi.org/10.1145/3572848.3577512'
chicago: Aksenov, Vitaly, Trevor A Brown, Alexander Fedorov, and Ilya Kokorin. Unexpected
Scaling in Path Copying Trees. Proceedings of the ACM SIGPLAN Symposium
on Principles and Practice of Parallel Programming. Association for Computing
Machinery, 2023. https://doi.org/10.1145/3572848.3577512.
ieee: V. Aksenov, T. A. Brown, A. Fedorov, and I. Kokorin, Unexpected scaling
in path copying trees. Association for Computing Machinery, 2023, pp. 438–440.
ista: Aksenov V, Brown TA, Fedorov A, Kokorin I. 2023. Unexpected scaling in path
copying trees, Association for Computing Machinery,p.
mla: Aksenov, Vitaly, et al. “Unexpected Scaling in Path Copying Trees.” Proceedings
of the ACM SIGPLAN Symposium on Principles and Practice of Parallel Programming,
Association for Computing Machinery, 2023, pp. 438–40, doi:10.1145/3572848.3577512.
short: V. Aksenov, T.A. Brown, A. Fedorov, I. Kokorin, Unexpected Scaling in Path
Copying Trees, Association for Computing Machinery, 2023.
conference:
end_date: 2023-03-01
location: Montreal, QB, Canada
name: 'PPoPP: Sympopsium on Principles and Practice of Parallel Programming'
start_date: 2023-02-25
date_created: 2023-03-19T23:00:58Z
date_published: 2023-02-25T00:00:00Z
date_updated: 2023-03-20T07:57:27Z
day: '25'
department:
- _id: DaAl
- _id: GradSch
doi: 10.1145/3572848.3577512
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1145/3572848.3577512
month: '02'
oa: 1
oa_version: Published Version
page: 438-440
publication: Proceedings of the ACM SIGPLAN Symposium on Principles and Practice of
Parallel Programming
publication_identifier:
isbn:
- '9798400700156'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
status: public
title: Unexpected scaling in path copying trees
type: conference_poster
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12716'
abstract:
- lang: eng
text: "The process of detecting and evaluating sensory information to guide behaviour
is termed perceptual decision-making (PDM), and is critical for the ability of
an organism to interact with its external world. Individuals with autism, a neurodevelopmental
condition primarily characterised by social and communication difficulties, frequently
exhibit altered sensory processing and PDM difficulties are widely reported. Recent
technological advancements have pushed forward our understanding of the genetic
changes accompanying this condition, however our understanding of how these mutations
affect the function of specific neuronal circuits and bring about the corresponding
behavioural changes remains limited. Here, we use an innate PDM task, the looming
avoidance response (LAR) paradigm, to identify a convergent behavioural abnormality
across three molecularly distinct genetic mouse models of autism (Cul3, Setd5
and Ptchd1). Although mutant mice can rapidly detect threatening visual stimuli,
their responses are consistently delayed, requiring longer to initiate an appropriate
response than their wild-type siblings. Mutant animals show abnormal adaptation
in both their stimulus- evoked escape responses and exploratory dynamics following
repeated stimulus presentations. Similarly delayed behavioural responses are observed
in wild-type animals when faced with more ambiguous threats, suggesting the mutant
phenotype could arise from a dysfunction in the flexible control of this PDM process.\r\nOur
knowledge of the core neuronal circuitry mediating the LAR facilitated a detailed
dissection of the neuronal mechanisms underlying the behavioural impairment. In
vivo extracellular recording revealed that visual responses were unaffected within
a key brain region for the rapid processing of visual threats, the superior colliculus
(SC), indicating that the behavioural delay was unlikely to originate from sensory
impairments. Delayed behavioural responses were recapitulated in the Setd5 model
following optogenetic stimulation of the excitatory output neurons of the SC,
which are known to mediate escape initiation through the activation of cells in
the underlying dorsal periaqueductal grey (dPAG). In vitro patch-clamp recordings
of dPAG cells uncovered a stark hypoexcitability phenotype in two out of the three
genetic models investigated (Setd5 and Ptchd1), that in Setd5, is mediated by
the misregulation of voltage-gated potassium channels. Overall, our results show
that the ability to use visual information to drive efficient escape responses
is impaired in three diverse genetic mouse models of autism and that, in one of
the models studied, this behavioural delay likely originates from differences
in the intrinsic excitability of a key subcortical node, the dPAG. Furthermore,
this work showcases the use of an innate behavioural paradigm to mechanistically
dissect PDM processes in autism."
acknowledged_ssus:
- _id: PreCl
- _id: Bio
- _id: LifeSc
- _id: M-Shop
- _id: CampIT
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Laura
full_name: Burnett, Laura
id: 3B717F68-F248-11E8-B48F-1D18A9856A87
last_name: Burnett
orcid: 0000-0002-8937-410X
citation:
ama: Burnett L. To flee, or not to flee? Using innate defensive behaviours to investigate
rapid perceptual decision-making through subcortical circuits in mouse models
of autism. 2023. doi:10.15479/at:ista:12716
apa: Burnett, L. (2023). To flee, or not to flee? Using innate defensive behaviours
to investigate rapid perceptual decision-making through subcortical circuits in
mouse models of autism. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12716
chicago: Burnett, Laura. “To Flee, or Not to Flee? Using Innate Defensive Behaviours
to Investigate Rapid Perceptual Decision-Making through Subcortical Circuits in
Mouse Models of Autism.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:12716.
ieee: L. Burnett, “To flee, or not to flee? Using innate defensive behaviours to
investigate rapid perceptual decision-making through subcortical circuits in mouse
models of autism,” Institute of Science and Technology Austria, 2023.
ista: Burnett L. 2023. To flee, or not to flee? Using innate defensive behaviours
to investigate rapid perceptual decision-making through subcortical circuits in
mouse models of autism. Institute of Science and Technology Austria.
mla: Burnett, Laura. To Flee, or Not to Flee? Using Innate Defensive Behaviours
to Investigate Rapid Perceptual Decision-Making through Subcortical Circuits in
Mouse Models of Autism. Institute of Science and Technology Austria, 2023,
doi:10.15479/at:ista:12716.
short: L. Burnett, To Flee, or Not to Flee? Using Innate Defensive Behaviours to
Investigate Rapid Perceptual Decision-Making through Subcortical Circuits in Mouse
Models of Autism, Institute of Science and Technology Austria, 2023.
date_created: 2023-03-08T15:19:45Z
date_published: 2023-03-10T00:00:00Z
date_updated: 2023-04-05T10:59:04Z
day: '10'
ddc:
- '599'
- '573'
degree_awarded: PhD
department:
- _id: GradSch
- _id: MaJö
doi: 10.15479/at:ista:12716
ec_funded: 1
file:
- access_level: closed
checksum: 6c6d9cc2c4cdacb74e6b1047a34d7332
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: lburnett
date_created: 2023-03-08T15:08:46Z
date_updated: 2023-03-08T15:08:46Z
file_id: '12717'
file_name: Burnett_Thesis_2023.docx
file_size: 23029260
relation: source_file
- access_level: open_access
checksum: cebc77705288bf4382db9b3541483cd0
content_type: application/pdf
creator: lburnett
date_created: 2023-03-08T15:08:46Z
date_updated: 2023-03-08T15:08:46Z
file_id: '12718'
file_name: Burnett_Thesis_2023_pdfA.pdf
file_size: 11959869
relation: main_file
success: 1
file_date_updated: 2023-03-08T15:08:46Z
has_accepted_license: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: '178'
project:
- _id: 2634E9D2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '756502'
name: Circuits of Visual Attention
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Maximilian A
full_name: Jösch, Maximilian A
id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
last_name: Jösch
orcid: 0000-0002-3937-1330
title: To flee, or not to flee? Using innate defensive behaviours to investigate rapid
perceptual decision-making through subcortical circuits in mouse models of autism
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12846'
abstract:
- lang: eng
text: We present a formula for the signed area of a spherical polygon via prequantization.
In contrast to the traditional formula based on the Gauss-Bonnet theorem that
requires measuring angles, the new formula mimics Green's theorem and is applicable
to a wider range of degenerate spherical curves and polygons.
acknowledgement: The authors acknowledge Chris Wojtan for his continuous support to
the present work through discussions and advice. The second author thanks Anna Sisak
for a fruitful discussion on prequantum bundles. This project was funded in part
by the European Research Council (ERC Consolidator Grant 101045083 CoDiNA).
article_number: '2303.14555'
article_processing_charge: No
author:
- first_name: Albert
full_name: Chern, Albert
last_name: Chern
- first_name: Sadashige
full_name: Ishida, Sadashige
id: 6F7C4B96-A8E9-11E9-A7CA-09ECE5697425
last_name: Ishida
citation:
ama: Chern A, Ishida S. Area formula for spherical polygons via prequantization.
arXiv. doi:10.48550/arXiv.2303.14555
apa: Chern, A., & Ishida, S. (n.d.). Area formula for spherical polygons via
prequantization. arXiv. https://doi.org/10.48550/arXiv.2303.14555
chicago: Chern, Albert, and Sadashige Ishida. “Area Formula for Spherical Polygons
via Prequantization.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2303.14555.
ieee: A. Chern and S. Ishida, “Area formula for spherical polygons via prequantization,”
arXiv. .
ista: Chern A, Ishida S. Area formula for spherical polygons via prequantization.
arXiv, 2303.14555.
mla: Chern, Albert, and Sadashige Ishida. “Area Formula for Spherical Polygons via
Prequantization.” ArXiv, 2303.14555, doi:10.48550/arXiv.2303.14555.
short: A. Chern, S. Ishida, ArXiv (n.d.).
date_created: 2023-04-18T19:16:06Z
date_published: 2023-03-25T00:00:00Z
date_updated: 2023-04-25T06:51:21Z
day: '25'
department:
- _id: GradSch
- _id: ChWo
doi: 10.48550/arXiv.2303.14555
external_id:
arxiv:
- '2303.14555'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2303.14555
month: '03'
oa: 1
oa_version: Preprint
project:
- _id: 34bc2376-11ca-11ed-8bc3-9a3b3961a088
grant_number: '101045083'
name: Computational Discovery of Numerical Algorithms for Animation and Simulation
of Natural Phenomena
publication: arXiv
publication_status: submitted
status: public
title: Area formula for spherical polygons via prequantization
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12809'
abstract:
- lang: eng
text: "Understanding the mechanisms of learning and memory formation has always
been one of\r\nthe main goals in neuroscience. Already Pavlov (1927) in his early
days has used his classic\r\nconditioning experiments to study the neural mechanisms
governing behavioral adaptation.\r\nWhat was not known back then was that the
part of the brain that is largely responsible for\r\nthis type of associative
learning is the cerebellum.\r\nSince then, plenty of theories on cerebellar learning
have emerged. Despite their differences,\r\none thing they all have in common
is that learning relies on synaptic and intrinsic plasticity.\r\nThe goal of my
PhD project was to unravel the molecular mechanisms underlying synaptic\r\nplasticity
in two synapses that have been shown to be implicated in motor learning, in an\r\neffort
to understand how learning and memory formation are processed in the cerebellum.\r\nOne
of the earliest and most well-known cerebellar theories postulates that motor
learning\r\nlargely depends on long-term depression at the parallel fiber-Purkinje
cell (PC-PC) synapse.\r\nHowever, the discovery of other types of plasticity in
the cerebellar circuitry, like long-term\r\npotentiation (LTP) at the PC-PC synapse,
potentiation of molecular layer interneurons (MLIs),\r\nand plasticity transfer
from the cortex to the cerebellar/ vestibular nuclei has increased the\r\npopularity
of the idea that multiple sites of plasticity might be involved in learning.\r\nStill
a lot remains unknown about the molecular mechanisms responsible for these types
of\r\nplasticity and whether they occur during physiological learning.\r\nIn the
first part of this thesis we have analyzed the variation and nanodistribution
of voltagegated calcium channels (VGCCs) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic
acid\r\ntype glutamate receptors (AMPARs) on the parallel fiber-Purkinje cell
synapse after vestibuloocular reflex phase reversal adaptation, a behavior that
has been suggested to rely on PF-PC\r\nLTP. We have found that on the last day
of adaptation there is no learning trace in form of\r\nVGCCs nor AMPARs variation
at the PF-PC synapse, but instead a decrease in the number of\r\nPF-PC synapses.
These data seem to support the view that learning is only stored in the\r\ncerebellar
cortex in an initial learning phase, being transferred later to the vestibular
nuclei.\r\nNext, we have studied the role of MLIs in motor learning using a relatively
simple and well characterized behavioral paradigm – horizontal optokinetic reflex
(HOKR) adaptation. We\r\nhave found behavior-induced MLI potentiation in form
of release probability increase that\r\ncould be explained by the increase of
VGCCs at the presynaptic side. Our results strengthen\r\nthe idea of distributed
cerebellar plasticity contributing to learning and provide a novel\r\nmechanism
for release probability increase. "
acknowledged_ssus:
- _id: EM-Fac
- _id: Bio
- _id: PreCl
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Catarina
full_name: Alcarva, Catarina
id: 3A96634C-F248-11E8-B48F-1D18A9856A87
last_name: Alcarva
citation:
ama: 'Alcarva C. Plasticity in the cerebellum: What molecular mechanisms are behind
physiological learning. 2023. doi:10.15479/at:ista:12809'
apa: 'Alcarva, C. (2023). Plasticity in the cerebellum: What molecular mechanisms
are behind physiological learning. Institute of Science and Technology Austria.
https://doi.org/10.15479/at:ista:12809'
chicago: 'Alcarva, Catarina. “Plasticity in the Cerebellum: What Molecular Mechanisms
Are behind Physiological Learning.” Institute of Science and Technology Austria,
2023. https://doi.org/10.15479/at:ista:12809.'
ieee: 'C. Alcarva, “Plasticity in the cerebellum: What molecular mechanisms are
behind physiological learning,” Institute of Science and Technology Austria, 2023.'
ista: 'Alcarva C. 2023. Plasticity in the cerebellum: What molecular mechanisms
are behind physiological learning. Institute of Science and Technology Austria.'
mla: 'Alcarva, Catarina. Plasticity in the Cerebellum: What Molecular Mechanisms
Are behind Physiological Learning. Institute of Science and Technology Austria,
2023, doi:10.15479/at:ista:12809.'
short: 'C. Alcarva, Plasticity in the Cerebellum: What Molecular Mechanisms Are
behind Physiological Learning, Institute of Science and Technology Austria, 2023.'
date_created: 2023-04-06T07:54:09Z
date_published: 2023-04-06T00:00:00Z
date_updated: 2023-04-26T12:16:56Z
day: '06'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: RySh
doi: 10.15479/at:ista:12809
file:
- access_level: closed
checksum: 35b5997d2b0acb461f9d33d073da0df5
content_type: application/pdf
creator: cchlebak
date_created: 2023-04-07T06:16:06Z
date_updated: 2023-04-07T06:16:06Z
embargo: 2024-04-07
embargo_to: open_access
file_id: '12814'
file_name: Thesis_CatarinaAlcarva_final pdfA.pdf
file_size: 9881969
relation: main_file
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checksum: 81198f63c294890f6d58e8b29782efdc
content_type: application/pdf
creator: cchlebak
date_created: 2023-04-07T06:17:11Z
date_updated: 2023-04-07T06:17:11Z
file_id: '12815'
file_name: Thesis_CatarinaAlcarva_final_for printing.pdf
file_size: 44201583
relation: source_file
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checksum: 0317bf7f457bb585f99d453ffa69eb53
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: cchlebak
date_created: 2023-04-07T06:18:05Z
date_updated: 2023-04-07T06:18:05Z
file_id: '12816'
file_name: Thesis_CatarinaAlcarva_final.docx
file_size: 84731244
relation: source_file
file_date_updated: 2023-04-07T06:18:05Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa_version: Published Version
page: '115'
project:
- _id: 267DFB90-B435-11E9-9278-68D0E5697425
name: 'Plasticity in the cerebellum: Which molecular mechanisms are behind physiological
learning?'
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
title: 'Plasticity in the cerebellum: What molecular mechanisms are behind physiological
learning'
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '13053'
abstract:
- lang: eng
text: 'Deep neural networks (DNNs) often have to be compressed, via pruning and/or
quantization, before they can be deployed in practical settings. In this work
we propose a new compression-aware minimizer dubbed CrAM that modifies the optimization
step in a principled way, in order to produce models whose local loss behavior
is stable under compression operations such as pruning. Thus, dense models trained
via CrAM should be compressible post-training, in a single step, without significant
accuracy loss. Experimental results on standard benchmarks, such as residual networks
for ImageNet classification and BERT models for language modelling, show that
CrAM produces dense models that can be more accurate than the standard SGD/Adam-based
baselines, but which are stable under weight pruning: specifically, we can prune
models in one-shot to 70-80% sparsity with almost no accuracy loss, and to 90%
with reasonable (∼1%) accuracy loss, which is competitive with gradual compression
methods. Additionally, CrAM can produce sparse models which perform well for transfer
learning, and it also works for semi-structured 2:4 pruning patterns supported
by GPU hardware. The code for reproducing the results is available at this https
URL .'
acknowledged_ssus:
- _id: ScienComp
acknowledgement: "AP, EK, DA received funding from the European Research Council (ERC)
under the European\r\nUnion’s Horizon 2020 research and innovation programme (grant
agreement No 805223 ScaleML). AV acknowledges the support of the French Agence Nationale
de la Recherche (ANR), under grant ANR-21-CE48-0016 (project COMCOPT). We further
acknowledge the support from the Scientific Service Units (SSU) of ISTA through
resources provided by Scientific Computing (SciComp)-"
article_processing_charge: No
author:
- first_name: Elena-Alexandra
full_name: Peste, Elena-Alexandra
id: 32D78294-F248-11E8-B48F-1D18A9856A87
last_name: Peste
- first_name: Adrian
full_name: Vladu, Adrian
last_name: Vladu
- first_name: Eldar
full_name: Kurtic, Eldar
id: 47beb3a5-07b5-11eb-9b87-b108ec578218
last_name: Kurtic
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
citation:
ama: 'Peste E-A, Vladu A, Kurtic E, Lampert C, Alistarh D-A. CrAM: A Compression-Aware
Minimizer. In: 11th International Conference on Learning Representations .'
apa: 'Peste, E.-A., Vladu, A., Kurtic, E., Lampert, C., & Alistarh, D.-A. (n.d.).
CrAM: A Compression-Aware Minimizer. In 11th International Conference on Learning
Representations . Kigali, Rwanda .'
chicago: 'Peste, Elena-Alexandra, Adrian Vladu, Eldar Kurtic, Christoph Lampert,
and Dan-Adrian Alistarh. “CrAM: A Compression-Aware Minimizer.” In 11th International
Conference on Learning Representations , n.d.'
ieee: 'E.-A. Peste, A. Vladu, E. Kurtic, C. Lampert, and D.-A. Alistarh, “CrAM:
A Compression-Aware Minimizer,” in 11th International Conference on Learning
Representations , Kigali, Rwanda .'
ista: 'Peste E-A, Vladu A, Kurtic E, Lampert C, Alistarh D-A. CrAM: A Compression-Aware
Minimizer. 11th International Conference on Learning Representations . ICLR: International
Conference on Learning Representations.'
mla: 'Peste, Elena-Alexandra, et al. “CrAM: A Compression-Aware Minimizer.” 11th
International Conference on Learning Representations .'
short: E.-A. Peste, A. Vladu, E. Kurtic, C. Lampert, D.-A. Alistarh, in:, 11th International
Conference on Learning Representations , n.d.
conference:
end_date: 2023-05-05
location: 'Kigali, Rwanda '
name: 'ICLR: International Conference on Learning Representations'
start_date: 2023-05-01
date_created: 2023-05-23T11:36:18Z
date_published: 2023-05-01T00:00:00Z
date_updated: 2023-06-01T12:54:45Z
department:
- _id: GradSch
- _id: DaAl
- _id: ChLa
ec_funded: 1
external_id:
arxiv:
- '2207.14200'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://openreview.net/pdf?id=_eTZBs-yedr
month: '05'
oa: 1
oa_version: Preprint
project:
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '805223'
name: Elastic Coordination for Scalable Machine Learning
publication: '11th International Conference on Learning Representations '
publication_status: accepted
quality_controlled: '1'
related_material:
record:
- id: '13074'
relation: dissertation_contains
status: public
status: public
title: 'CrAM: A Compression-Aware Minimizer'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12826'
abstract:
- lang: eng
text: "During navigation, animals can infer the structure of the environment by
computing the optic flow cues elicited by their own movements, and subsequently
use this information to instruct proper locomotor actions. These computations
require a panoramic assessment of the visual environment in order to disambiguate
similar sensory experiences that may require distinct behavioral responses. The
estimation of the global motion patterns is therefore essential for successful
navigation. Yet, our understanding of the algorithms and implementations that
enable coherent panoramic visual perception remains scarce. Here I pursue this
problem by dissecting the functional aspects of interneuronal communication in
the lobula plate tangential cell network in Drosophila melanogaster. The results
presented in the thesis demonstrate that the basis for effective interpretation
of the optic flow in this circuit are stereotyped synaptic connections that mediate
the formation of distinct subnetworks, each extracting a particular pattern of
global motion. \r\nFirstly, I show that gap junctions are essential for a correct
interpretation of binocular motion cues by horizontal motion-sensitive cells.
HS cells form electrical synapses with contralateral H2 neurons that are involved
in detecting yaw rotation and translation. I developed an FlpStop-mediated mutant
of a gap junction protein ShakB that disrupts these electrical synapses. While
the loss of electrical synapses does not affect the tuning of the direction selectivity
in HS neurons, it severely alters their sensitivity to horizontal motion in the
contralateral side. These physiological changes result in an inappropriate integration
of binocular motion cues in walking animals. While wild-type flies form a binocular
perception of visual motion by non-linear integration of monocular optic flow
cues, the mutant flies sum the monocular inputs linearly. These results indicate
that rather than averaging signals in neighboring neurons, gap-junctions operate
in conjunction with chemical synapses to mediate complex non-linear optic flow
computations.\r\nSecondly, I show that stochastic manipulation of neuronal activity
in the lobula plate tangential cell network is a powerful approach to study the
neuronal implementation of optic flow-based navigation in flies. Tangential neurons
form multiple subnetworks, each mediating course-stabilizing response to a particular
global pattern of visual motion. Application of genetic mosaic techniques can
provide sparse optogenetic activation of HS cells in numerous combinations. These
distinct combinations of activated neurons drive an array of distinct behavioral
responses, providing important insights into how visuomotor transformation is
performed in the lobula plate tangential cell network. This approach can be complemented
by stochastic silencing of tangential neurons, enabling direct assessment of the
functional role of individual tangential neurons in the processing of specific
visual motion patterns.\r\n\tTaken together, the findings presented in this thesis
suggest that establishing specific activity patterns of tangential cells via stereotyped
synaptic connectivity is a key to efficient optic flow-based navigation in Drosophila
melanogaster."
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Victoria
full_name: Pokusaeva, Victoria
id: 3184041C-F248-11E8-B48F-1D18A9856A87
last_name: Pokusaeva
orcid: 0000-0001-7660-444X
citation:
ama: Pokusaeva V. Neural control of optic flow-based navigation in Drosophila melanogaster.
2023. doi:10.15479/at:ista:12826
apa: Pokusaeva, V. (2023). Neural control of optic flow-based navigation in Drosophila
melanogaster. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12826
chicago: Pokusaeva, Victoria. “Neural Control of Optic Flow-Based Navigation in
Drosophila Melanogaster.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:12826.
ieee: V. Pokusaeva, “Neural control of optic flow-based navigation in Drosophila
melanogaster,” Institute of Science and Technology Austria, 2023.
ista: Pokusaeva V. 2023. Neural control of optic flow-based navigation in Drosophila
melanogaster. Institute of Science and Technology Austria.
mla: Pokusaeva, Victoria. Neural Control of Optic Flow-Based Navigation in Drosophila
Melanogaster. Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:12826.
short: V. Pokusaeva, Neural Control of Optic Flow-Based Navigation in Drosophila
Melanogaster, Institute of Science and Technology Austria, 2023.
date_created: 2023-04-14T14:56:04Z
date_published: 2023-04-18T00:00:00Z
date_updated: 2023-06-23T09:47:36Z
day: '18'
ddc:
- '570'
- '571'
degree_awarded: PhD
department:
- _id: MaJö
- _id: GradSch
doi: 10.15479/at:ista:12826
ec_funded: 1
file:
- access_level: closed
checksum: 5f589a9af025f7eeebfd0c186209913e
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: vpokusae
date_created: 2023-04-20T09:14:38Z
date_updated: 2023-04-20T09:26:51Z
file_id: '12857'
file_name: Thesis_Pokusaeva.docx
file_size: 14507243
relation: source_file
- access_level: open_access
checksum: bbeed76db45a996b4c91a9abe12ce0ec
content_type: application/pdf
creator: vpokusae
date_created: 2023-04-20T09:14:44Z
date_updated: 2023-04-20T09:14:44Z
file_id: '12858'
file_name: Thesis_Pokusaeva.pdf
file_size: 10090711
relation: main_file
success: 1
file_date_updated: 2023-04-20T09:26:51Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: '106'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Maximilian A
full_name: Jösch, Maximilian A
id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
last_name: Jösch
orcid: 0000-0002-3937-1330
title: Neural control of optic flow-based navigation in Drosophila melanogaster
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12467'
abstract:
- lang: eng
text: Safety and liveness are elementary concepts of computation, and the foundation
of many verification paradigms. The safety-liveness classification of boolean
properties characterizes whether a given property can be falsified by observing
a finite prefix of an infinite computation trace (always for safety, never for
liveness). In quantitative specification and verification, properties assign not
truth values, but quantitative values to infinite traces (e.g., a cost, or the
distance to a boolean property). We introduce quantitative safety and liveness,
and we prove that our definitions induce conservative quantitative generalizations
of both (1)~the safety-progress hierarchy of boolean properties and (2)~the safety-liveness
decomposition of boolean properties. In particular, we show that every quantitative
property can be written as the pointwise minimum of a quantitative safety property
and a quantitative liveness property. Consequently, like boolean properties, also
quantitative properties can be min-decomposed into safety and liveness parts,
or alternatively, max-decomposed into co-safety and co-liveness parts. Moreover,
quantitative properties can be approximated naturally. We prove that every quantitative
property that has both safe and co-safe approximations can be monitored arbitrarily
precisely by a monitor that uses only a finite number of states.
acknowledgement: We thank the anonymous reviewers for their helpful comments. This
work was supported in part by the ERC-2020-AdG 101020093.
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
- first_name: Nicolas Adrien
full_name: Mazzocchi, Nicolas Adrien
id: b26baa86-3308-11ec-87b0-8990f34baa85
last_name: Mazzocchi
- first_name: Naci E
full_name: Sarac, Naci E
id: 8C6B42F8-C8E6-11E9-A03A-F2DCE5697425
last_name: Sarac
citation:
ama: 'Henzinger TA, Mazzocchi NA, Sarac NE. Quantitative safety and liveness. In:
26th International Conference Foundations of Software Science and Computation
Structures. Vol 13992. Springer Nature; 2023:349-370. doi:10.1007/978-3-031-30829-1_17'
apa: 'Henzinger, T. A., Mazzocchi, N. A., & Sarac, N. E. (2023). Quantitative
safety and liveness. In 26th International Conference Foundations of Software
Science and Computation Structures (Vol. 13992, pp. 349–370). Paris, France:
Springer Nature. https://doi.org/10.1007/978-3-031-30829-1_17'
chicago: Henzinger, Thomas A, Nicolas Adrien Mazzocchi, and Naci E Sarac. “Quantitative
Safety and Liveness.” In 26th International Conference Foundations of Software
Science and Computation Structures, 13992:349–70. Springer Nature, 2023. https://doi.org/10.1007/978-3-031-30829-1_17.
ieee: T. A. Henzinger, N. A. Mazzocchi, and N. E. Sarac, “Quantitative safety and
liveness,” in 26th International Conference Foundations of Software Science
and Computation Structures, Paris, France, 2023, vol. 13992, pp. 349–370.
ista: 'Henzinger TA, Mazzocchi NA, Sarac NE. 2023. Quantitative safety and liveness.
26th International Conference Foundations of Software Science and Computation
Structures. FOSSACS: Foundations of Software Science and Computation Structures,
LNCS, vol. 13992, 349–370.'
mla: Henzinger, Thomas A., et al. “Quantitative Safety and Liveness.” 26th International
Conference Foundations of Software Science and Computation Structures, vol.
13992, Springer Nature, 2023, pp. 349–70, doi:10.1007/978-3-031-30829-1_17.
short: T.A. Henzinger, N.A. Mazzocchi, N.E. Sarac, in:, 26th International Conference
Foundations of Software Science and Computation Structures, Springer Nature, 2023,
pp. 349–370.
conference:
end_date: 2023-04-27
location: Paris, France
name: 'FOSSACS: Foundations of Software Science and Computation Structures'
start_date: 2023-04-22
date_created: 2023-01-31T07:23:56Z
date_published: 2023-04-21T00:00:00Z
date_updated: 2023-07-14T11:20:27Z
day: '21'
ddc:
- '000'
department:
- _id: GradSch
- _id: ToHe
doi: 10.1007/978-3-031-30829-1_17
ec_funded: 1
external_id:
arxiv:
- '2301.11175'
file:
- access_level: open_access
checksum: 981025aed580b6b27c426cb8856cf63e
content_type: application/pdf
creator: esarac
date_created: 2023-01-31T07:22:21Z
date_updated: 2023-01-31T07:22:21Z
file_id: '12468'
file_name: qsl.pdf
file_size: 449027
relation: main_file
success: 1
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content_type: application/pdf
creator: dernst
date_created: 2023-06-19T10:28:09Z
date_updated: 2023-06-19T10:28:09Z
file_id: '13153'
file_name: 2023_LNCS_HenzingerT.pdf
file_size: 1048171
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success: 1
file_date_updated: 2023-06-19T10:28:09Z
has_accepted_license: '1'
intvolume: ' 13992'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 349-370
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
call_identifier: H2020
grant_number: '101020093'
name: Vigilant Algorithmic Monitoring of Software
publication: 26th International Conference Foundations of Software Science and Computation
Structures
publication_identifier:
eissn:
- 1611-3349
isbn:
- '9783031308284'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Quantitative safety and liveness
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
volume: 13992
year: '2023'
...
---
_id: '13292'
abstract:
- lang: eng
text: The operator precedence languages (OPLs) represent the largest known subclass
of the context-free languages which enjoys all desirable closure and decidability
properties. This includes the decidability of language inclusion, which is the
ultimate verification problem. Operator precedence grammars, automata, and logics
have been investigated and used, for example, to verify programs with arithmetic
expressions and exceptions (both of which are deterministic pushdown but lie outside
the scope of the visibly pushdown languages). In this paper, we complete the picture
and give, for the first time, an algebraic characterization of the class of OPLs
in the form of a syntactic congruence that has finitely many equivalence classes
exactly for the operator precedence languages. This is a generalization of the
celebrated Myhill-Nerode theorem for the regular languages to OPLs. As one of
the consequences, we show that universality and language inclusion for nondeterministic
operator precedence automata can be solved by an antichain algorithm. Antichain
algorithms avoid determinization and complementation through an explicit subset
construction, by leveraging a quasi-order on words, which allows the pruning of
the search space for counterexample words without sacrificing completeness. Antichain
algorithms can be implemented symbolically, and these implementations are today
the best-performing algorithms in practice for the inclusion of finite automata.
We give a generic construction of the quasi-order needed for antichain algorithms
from a finite syntactic congruence. This yields the first antichain algorithm
for OPLs, an algorithm that solves the ExpTime-hard language inclusion problem
for OPLs in exponential time.
acknowledgement: "This work was supported in part by the ERC-2020-AdG 101020093.\r\nWe
thank Pierre Ganty for early discussions and the anonymous reviewers for their helpful
comments.\r\n"
alternative_title:
- LIPIcs
article_processing_charge: Yes
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
- first_name: Pavol
full_name: Kebis, Pavol
last_name: Kebis
- first_name: Nicolas Adrien
full_name: Mazzocchi, Nicolas Adrien
id: b26baa86-3308-11ec-87b0-8990f34baa85
last_name: Mazzocchi
- first_name: Naci E
full_name: Sarac, Naci E
id: 8C6B42F8-C8E6-11E9-A03A-F2DCE5697425
last_name: Sarac
citation:
ama: 'Henzinger TA, Kebis P, Mazzocchi NA, Sarac NE. Regular methods for operator
precedence languages. In: 50th International Colloquium on Automata, Languages,
and Programming. Vol 261. Schloss Dagstuhl - Leibniz-Zentrum für Informatik;
2023:129:1--129:20. doi:10.4230/LIPIcs.ICALP.2023.129'
apa: 'Henzinger, T. A., Kebis, P., Mazzocchi, N. A., & Sarac, N. E. (2023).
Regular methods for operator precedence languages. In 50th International Colloquium
on Automata, Languages, and Programming (Vol. 261, p. 129:1--129:20). Paderborn,
Germany: Schloss Dagstuhl - Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.ICALP.2023.129'
chicago: Henzinger, Thomas A, Pavol Kebis, Nicolas Adrien Mazzocchi, and Naci E
Sarac. “Regular Methods for Operator Precedence Languages.” In 50th International
Colloquium on Automata, Languages, and Programming, 261:129:1--129:20. Schloss
Dagstuhl - Leibniz-Zentrum für Informatik, 2023. https://doi.org/10.4230/LIPIcs.ICALP.2023.129.
ieee: T. A. Henzinger, P. Kebis, N. A. Mazzocchi, and N. E. Sarac, “Regular methods
for operator precedence languages,” in 50th International Colloquium on Automata,
Languages, and Programming, Paderborn, Germany, 2023, vol. 261, p. 129:1--129:20.
ista: 'Henzinger TA, Kebis P, Mazzocchi NA, Sarac NE. 2023. Regular methods for
operator precedence languages. 50th International Colloquium on Automata, Languages,
and Programming. ICALP: International Colloquium on Automata, Languages, and Programming,
LIPIcs, vol. 261, 129:1--129:20.'
mla: Henzinger, Thomas A., et al. “Regular Methods for Operator Precedence Languages.”
50th International Colloquium on Automata, Languages, and Programming,
vol. 261, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2023, p. 129:1--129:20,
doi:10.4230/LIPIcs.ICALP.2023.129.
short: T.A. Henzinger, P. Kebis, N.A. Mazzocchi, N.E. Sarac, in:, 50th International
Colloquium on Automata, Languages, and Programming, Schloss Dagstuhl - Leibniz-Zentrum
für Informatik, 2023, p. 129:1--129:20.
conference:
end_date: 2023-07-14
location: Paderborn, Germany
name: 'ICALP: International Colloquium on Automata, Languages, and Programming'
start_date: 2023-07-10
date_created: 2023-07-24T15:11:41Z
date_published: 2023-07-05T00:00:00Z
date_updated: 2023-07-31T08:38:38Z
day: '05'
ddc:
- '000'
department:
- _id: GradSch
- _id: ToHe
doi: 10.4230/LIPIcs.ICALP.2023.129
ec_funded: 1
external_id:
arxiv:
- '2305.03447'
file:
- access_level: open_access
checksum: 5d4c8932ef3450615a53b9bb15d92eb2
content_type: application/pdf
creator: esarac
date_created: 2023-07-24T15:11:05Z
date_updated: 2023-07-24T15:11:05Z
file_id: '13293'
file_name: icalp23.pdf
file_size: 859379
relation: main_file
success: 1
file_date_updated: 2023-07-24T15:11:05Z
has_accepted_license: '1'
intvolume: ' 261'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 129:1--129:20
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
call_identifier: H2020
grant_number: '101020093'
name: Vigilant Algorithmic Monitoring of Software
publication: 50th International Colloquium on Automata, Languages, and Programming
publication_identifier:
eissn:
- 1868-8969
isbn:
- '9783959772785'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
status: public
title: Regular methods for operator precedence languages
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 261
year: '2023'
...
---
_id: '13262'
abstract:
- lang: eng
text: 'Determining the degree of inherent parallelism in classical sequential algorithms
and leveraging it for fast parallel execution is a key topic in parallel computing,
and detailed analyses are known for a wide range of classical algorithms. In this
paper, we perform the first such analysis for the fundamental Union-Find problem,
in which we are given a graph as a sequence of edges, and must maintain its connectivity
structure under edge additions. We prove that classic sequential algorithms for
this problem are well-parallelizable under reasonable assumptions, addressing
a conjecture by [Blelloch, 2017]. More precisely, we show via a new potential
argument that, under uniform random edge ordering, parallel union-find operations
are unlikely to interfere: T concurrent threads processing the graph in parallel
will encounter memory contention O(T2 · log |V| · log |E|) times in expectation,
where |E| and |V| are the number of edges and nodes in the graph, respectively.
We leverage this result to design a new parallel Union-Find algorithm that is
both internally deterministic, i.e., its results are guaranteed to match those
of a sequential execution, but also work-efficient and scalable, as long as the
number of threads T is O(|E|1 over 3 - ε), for an arbitrarily small constant ε
> 0, which holds for most large real-world graphs. We present lower bounds which
show that our analysis is close to optimal, and experimental results suggesting
that the performance cost of internal determinism is limited.'
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Alexander
full_name: Fedorov, Alexander
id: 2e711909-896a-11ed-bdf8-eb0f5a2984c6
last_name: Fedorov
- first_name: Diba
full_name: Hashemi, Diba
id: ed9595ea-2f8f-11ee-ba95-d2b546540783
last_name: Hashemi
- first_name: Giorgi
full_name: Nadiradze, Giorgi
id: 3279A00C-F248-11E8-B48F-1D18A9856A87
last_name: Nadiradze
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
citation:
ama: 'Fedorov A, Hashemi D, Nadiradze G, Alistarh D-A. Provably-efficient and internally-deterministic
parallel Union-Find. In: Proceedings of the 35th ACM Symposium on Parallelism
in Algorithms and Architectures. Association for Computing Machinery; 2023:261-271.
doi:10.1145/3558481.3591082'
apa: 'Fedorov, A., Hashemi, D., Nadiradze, G., & Alistarh, D.-A. (2023). Provably-efficient
and internally-deterministic parallel Union-Find. In Proceedings of the 35th
ACM Symposium on Parallelism in Algorithms and Architectures (pp. 261–271).
Orlando, FL, United States: Association for Computing Machinery. https://doi.org/10.1145/3558481.3591082'
chicago: Fedorov, Alexander, Diba Hashemi, Giorgi Nadiradze, and Dan-Adrian Alistarh.
“Provably-Efficient and Internally-Deterministic Parallel Union-Find.” In Proceedings
of the 35th ACM Symposium on Parallelism in Algorithms and Architectures,
261–71. Association for Computing Machinery, 2023. https://doi.org/10.1145/3558481.3591082.
ieee: A. Fedorov, D. Hashemi, G. Nadiradze, and D.-A. Alistarh, “Provably-efficient
and internally-deterministic parallel Union-Find,” in Proceedings of the 35th
ACM Symposium on Parallelism in Algorithms and Architectures, Orlando, FL,
United States, 2023, pp. 261–271.
ista: 'Fedorov A, Hashemi D, Nadiradze G, Alistarh D-A. 2023. Provably-efficient
and internally-deterministic parallel Union-Find. Proceedings of the 35th ACM
Symposium on Parallelism in Algorithms and Architectures. SPAA: Symposium on Parallelism
in Algorithms and Architectures, 261–271.'
mla: Fedorov, Alexander, et al. “Provably-Efficient and Internally-Deterministic
Parallel Union-Find.” Proceedings of the 35th ACM Symposium on Parallelism
in Algorithms and Architectures, Association for Computing Machinery, 2023,
pp. 261–71, doi:10.1145/3558481.3591082.
short: A. Fedorov, D. Hashemi, G. Nadiradze, D.-A. Alistarh, in:, Proceedings of
the 35th ACM Symposium on Parallelism in Algorithms and Architectures, Association
for Computing Machinery, 2023, pp. 261–271.
conference:
end_date: 2023-06-19
location: Orlando, FL, United States
name: 'SPAA: Symposium on Parallelism in Algorithms and Architectures'
start_date: 2023-06-17
date_created: 2023-07-23T22:01:12Z
date_published: 2023-06-17T00:00:00Z
date_updated: 2023-07-31T10:54:32Z
day: '17'
ddc:
- '000'
department:
- _id: DaAl
- _id: GradSch
doi: 10.1145/3558481.3591082
external_id:
arxiv:
- '2304.09331'
file:
- access_level: open_access
checksum: 72e312aabf0c5248c99b5cd3a88e4c88
content_type: application/pdf
creator: dernst
date_created: 2023-07-31T10:53:08Z
date_updated: 2023-07-31T10:53:08Z
file_id: '13334'
file_name: 2023_SPAA_Fedorov.pdf
file_size: 2087937
relation: main_file
success: 1
file_date_updated: 2023-07-31T10:53:08Z
has_accepted_license: '1'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 261-271
publication: Proceedings of the 35th ACM Symposium on Parallelism in Algorithms and
Architectures
publication_identifier:
isbn:
- '9781450395458'
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
scopus_import: '1'
status: public
title: Provably-efficient and internally-deterministic parallel Union-Find
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12545'
abstract:
- lang: eng
text: We study active surface wetting using a minimal model of bacteria that takes
into account the intrinsic motility diversity of living matter. A mixture of “fast”
and “slow” self-propelled Brownian particles is considered in the presence of
a wall. The evolution of the wetting layer thickness shows an overshoot before
stationarity and its composition evolves in two stages, equilibrating after a
slow elimination of excess particles. Nonmonotonic evolutions are shown to arise
from delayed avalanches towards the dilute phase combined with the emergence of
a transient particle front.
acknowledgement: 'MR-V and RS are supported by Fondecyt Grant No. 1220536 and ANID
– Millennium Science Initiative Program – NCN19 170D, Chile. PdC is supported by
grant #2021/10139-2, Sao Paulo Research Foundation (FAPESP), Brazil.'
article_number: '014608'
article_processing_charge: No
article_type: original
author:
- first_name: Mauricio Nicolas
full_name: Rojas Vega, Mauricio Nicolas
id: 441e7207-f91f-11ec-b67c-9e6fe3d8fd6d
last_name: Rojas Vega
- first_name: Pablo
full_name: De Castro, Pablo
last_name: De Castro
- first_name: Rodrigo
full_name: Soto, Rodrigo
last_name: Soto
citation:
ama: Rojas Vega MN, De Castro P, Soto R. Wetting dynamics by mixtures of fast and
slow self-propelled particles. Physical Review E. 2023;107(1). doi:10.1103/PhysRevE.107.014608
apa: Rojas Vega, M. N., De Castro, P., & Soto, R. (2023). Wetting dynamics by
mixtures of fast and slow self-propelled particles. Physical Review E.
American Physical Society. https://doi.org/10.1103/PhysRevE.107.014608
chicago: Rojas Vega, Mauricio Nicolas, Pablo De Castro, and Rodrigo Soto. “Wetting
Dynamics by Mixtures of Fast and Slow Self-Propelled Particles.” Physical Review
E. American Physical Society, 2023. https://doi.org/10.1103/PhysRevE.107.014608.
ieee: M. N. Rojas Vega, P. De Castro, and R. Soto, “Wetting dynamics by mixtures
of fast and slow self-propelled particles,” Physical Review E, vol. 107,
no. 1. American Physical Society, 2023.
ista: Rojas Vega MN, De Castro P, Soto R. 2023. Wetting dynamics by mixtures of
fast and slow self-propelled particles. Physical Review E. 107(1), 014608.
mla: Rojas Vega, Mauricio Nicolas, et al. “Wetting Dynamics by Mixtures of Fast
and Slow Self-Propelled Particles.” Physical Review E, vol. 107, no. 1,
014608, American Physical Society, 2023, doi:10.1103/PhysRevE.107.014608.
short: M.N. Rojas Vega, P. De Castro, R. Soto, Physical Review E 107 (2023).
date_created: 2023-02-12T23:00:59Z
date_published: 2023-01-24T00:00:00Z
date_updated: 2023-08-01T13:09:45Z
day: '24'
department:
- _id: GradSch
doi: 10.1103/PhysRevE.107.014608
external_id:
arxiv:
- '2301.01856'
isi:
- '000963909800006'
intvolume: ' 107'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2301.01856
month: '01'
oa: 1
oa_version: Preprint
publication: Physical Review E
publication_identifier:
eissn:
- 2470-0053
issn:
- 2470-0045
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Wetting dynamics by mixtures of fast and slow self-propelled particles
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 107
year: '2023'
...
---
_id: '12723'
abstract:
- lang: eng
text: 'Lead halide perovskites enjoy a number of remarkable optoelectronic properties.
To explain their origin, it is necessary to study how electromagnetic fields interact
with these systems. We address this problem here by studying two classical quantities:
Faraday rotation and the complex refractive index in a paradigmatic perovskite
CH3NH3PbBr3 in a broad wavelength range. We find that the minimal coupling of
electromagnetic fields to the k⋅p Hamiltonian is insufficient to describe the
observed data even on the qualitative level. To amend this, we demonstrate that
there exists a relevant atomic-level coupling between electromagnetic fields and
the spin degree of freedom. This spin-electric coupling allows for quantitative
description of a number of previous as well as present experimental data. In particular,
we use it here to show that the Faraday effect in lead halide perovskites is dominated
by the Zeeman splitting of the energy levels and has a substantial beyond-Becquerel
contribution. Finally, we present general symmetry-based phenomenological arguments
that in the low-energy limit our effective model includes all basis coupling terms
to the electromagnetic field in the linear order.'
article_number: '106901'
article_processing_charge: No
article_type: original
author:
- first_name: Artem
full_name: Volosniev, Artem
id: 37D278BC-F248-11E8-B48F-1D18A9856A87
last_name: Volosniev
orcid: 0000-0003-0393-5525
- first_name: Abhishek
full_name: Shiva Kumar, Abhishek
id: 5e9a6931-eb97-11eb-a6c2-e96f7058d77a
last_name: Shiva Kumar
- first_name: Dusan
full_name: Lorenc, Dusan
id: 40D8A3E6-F248-11E8-B48F-1D18A9856A87
last_name: Lorenc
- first_name: Younes
full_name: Ashourishokri, Younes
id: e32c111f-f6e0-11ea-865d-eb955baea334
last_name: Ashourishokri
- first_name: Ayan A.
full_name: Zhumekenov, Ayan A.
last_name: Zhumekenov
- first_name: Osman M.
full_name: Bakr, Osman M.
last_name: Bakr
- first_name: Mikhail
full_name: Lemeshko, Mikhail
id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
last_name: Lemeshko
orcid: 0000-0002-6990-7802
- first_name: Zhanybek
full_name: Alpichshev, Zhanybek
id: 45E67A2A-F248-11E8-B48F-1D18A9856A87
last_name: Alpichshev
orcid: 0000-0002-7183-5203
citation:
ama: Volosniev A, Shiva Kumar A, Lorenc D, et al. Spin-electric coupling in lead
halide perovskites. Physical Review Letters. 2023;130(10). doi:10.1103/physrevlett.130.106901
apa: Volosniev, A., Shiva Kumar, A., Lorenc, D., Ashourishokri, Y., Zhumekenov,
A. A., Bakr, O. M., … Alpichshev, Z. (2023). Spin-electric coupling in lead halide
perovskites. Physical Review Letters. American Physical Society. https://doi.org/10.1103/physrevlett.130.106901
chicago: Volosniev, Artem, Abhishek Shiva Kumar, Dusan Lorenc, Younes Ashourishokri,
Ayan A. Zhumekenov, Osman M. Bakr, Mikhail Lemeshko, and Zhanybek Alpichshev.
“Spin-Electric Coupling in Lead Halide Perovskites.” Physical Review Letters.
American Physical Society, 2023. https://doi.org/10.1103/physrevlett.130.106901.
ieee: A. Volosniev et al., “Spin-electric coupling in lead halide perovskites,”
Physical Review Letters, vol. 130, no. 10. American Physical Society, 2023.
ista: Volosniev A, Shiva Kumar A, Lorenc D, Ashourishokri Y, Zhumekenov AA, Bakr
OM, Lemeshko M, Alpichshev Z. 2023. Spin-electric coupling in lead halide perovskites.
Physical Review Letters. 130(10), 106901.
mla: Volosniev, Artem, et al. “Spin-Electric Coupling in Lead Halide Perovskites.”
Physical Review Letters, vol. 130, no. 10, 106901, American Physical Society,
2023, doi:10.1103/physrevlett.130.106901.
short: A. Volosniev, A. Shiva Kumar, D. Lorenc, Y. Ashourishokri, A.A. Zhumekenov,
O.M. Bakr, M. Lemeshko, Z. Alpichshev, Physical Review Letters 130 (2023).
date_created: 2023-03-14T13:11:59Z
date_published: 2023-03-10T00:00:00Z
date_updated: 2023-08-01T13:39:04Z
day: '10'
department:
- _id: GradSch
- _id: ZhAl
- _id: MiLe
doi: 10.1103/physrevlett.130.106901
external_id:
arxiv:
- '2203.09443'
isi:
- '000982435900002'
intvolume: ' 130'
isi: 1
issue: '10'
keyword:
- General Physics and Astronomy
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2203.09443
month: '03'
oa: 1
oa_version: Preprint
publication: Physical Review Letters
publication_identifier:
eissn:
- 1079-7114
issn:
- 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spin-electric coupling in lead halide perovskites
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 130
year: '2023'
...
---
_id: '12724'
abstract:
- lang: eng
text: 'We use general symmetry-based arguments to construct an effective model suitable
for studying optical properties of lead halide perovskites. To build the model,
we identify an atomic-level interaction between electromagnetic fields and the
spin degree of freedom that should be added to a minimally coupled k⋅p Hamiltonian.
As a first application, we study two basic optical characteristics of the material:
the Verdet constant and the refractive index. Beyond these linear characteristics
of the material, the model is suitable for calculating nonlinear effects such
as the third-order optical susceptibility. Analysis of this quantity shows that
the geometrical properties of the spin-electric term imply isotropic optical response
of the system, and that optical anisotropy of lead halide perovskites is a manifestation
of hopping of charge carriers. To illustrate this, we discuss third-harmonic generation.'
article_number: '125201'
article_processing_charge: No
article_type: original
author:
- first_name: Artem
full_name: Volosniev, Artem
id: 37D278BC-F248-11E8-B48F-1D18A9856A87
last_name: Volosniev
orcid: 0000-0003-0393-5525
- first_name: Abhishek
full_name: Shiva Kumar, Abhishek
id: 5e9a6931-eb97-11eb-a6c2-e96f7058d77a
last_name: Shiva Kumar
- first_name: Dusan
full_name: Lorenc, Dusan
id: 40D8A3E6-F248-11E8-B48F-1D18A9856A87
last_name: Lorenc
- first_name: Younes
full_name: Ashourishokri, Younes
id: e32c111f-f6e0-11ea-865d-eb955baea334
last_name: Ashourishokri
- first_name: Ayan
full_name: Zhumekenov, Ayan
last_name: Zhumekenov
- first_name: Osman M.
full_name: Bakr, Osman M.
last_name: Bakr
- first_name: Mikhail
full_name: Lemeshko, Mikhail
id: 37CB05FA-F248-11E8-B48F-1D18A9856A87
last_name: Lemeshko
orcid: 0000-0002-6990-7802
- first_name: Zhanybek
full_name: Alpichshev, Zhanybek
id: 45E67A2A-F248-11E8-B48F-1D18A9856A87
last_name: Alpichshev
orcid: 0000-0002-7183-5203
citation:
ama: Volosniev A, Shiva Kumar A, Lorenc D, et al. Effective model for studying optical
properties of lead halide perovskites. Physical Review B. 2023;107(12).
doi:10.1103/physrevb.107.125201
apa: Volosniev, A., Shiva Kumar, A., Lorenc, D., Ashourishokri, Y., Zhumekenov,
A., Bakr, O. M., … Alpichshev, Z. (2023). Effective model for studying optical
properties of lead halide perovskites. Physical Review B. American Physical
Society. https://doi.org/10.1103/physrevb.107.125201
chicago: Volosniev, Artem, Abhishek Shiva Kumar, Dusan Lorenc, Younes Ashourishokri,
Ayan Zhumekenov, Osman M. Bakr, Mikhail Lemeshko, and Zhanybek Alpichshev. “Effective
Model for Studying Optical Properties of Lead Halide Perovskites.” Physical
Review B. American Physical Society, 2023. https://doi.org/10.1103/physrevb.107.125201.
ieee: A. Volosniev et al., “Effective model for studying optical properties
of lead halide perovskites,” Physical Review B, vol. 107, no. 12. American
Physical Society, 2023.
ista: Volosniev A, Shiva Kumar A, Lorenc D, Ashourishokri Y, Zhumekenov A, Bakr
OM, Lemeshko M, Alpichshev Z. 2023. Effective model for studying optical properties
of lead halide perovskites. Physical Review B. 107(12), 125201.
mla: Volosniev, Artem, et al. “Effective Model for Studying Optical Properties of
Lead Halide Perovskites.” Physical Review B, vol. 107, no. 12, 125201,
American Physical Society, 2023, doi:10.1103/physrevb.107.125201.
short: A. Volosniev, A. Shiva Kumar, D. Lorenc, Y. Ashourishokri, A. Zhumekenov,
O.M. Bakr, M. Lemeshko, Z. Alpichshev, Physical Review B 107 (2023).
date_created: 2023-03-14T13:13:05Z
date_published: 2023-03-15T00:00:00Z
date_updated: 2023-08-01T13:39:47Z
day: '15'
department:
- _id: GradSch
- _id: ZhAl
- _id: MiLe
doi: 10.1103/physrevb.107.125201
external_id:
arxiv:
- '2204.04022'
isi:
- '000972602200006'
intvolume: ' 107'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2204.04022
month: '03'
oa: 1
oa_version: Preprint
publication: Physical Review B
publication_identifier:
eissn:
- 2469-9969
issn:
- 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Effective model for studying optical properties of lead halide perovskites
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 107
year: '2023'
...
---
_id: '13166'
abstract:
- lang: eng
text: Brachyury, a member of T-box gene family, is widely known for its major role
in mesoderm specification in bilaterians. It is also present in non-bilaterian
metazoans, such as cnidarians, where it acts as a component of an axial patterning
system. In this study, we present a phylogenetic analysis of Brachyury genes within
phylum Cnidaria, investigate differential expression and address a functional
framework of Brachyury paralogs in hydrozoan Dynamena pumila. Our analysis indicates
two duplication events of Brachyury within the cnidarian lineage. The first duplication
likely appeared in the medusozoan ancestor, resulting in two copies in medusozoans,
while the second duplication arose in the hydrozoan ancestor, resulting in three
copies in hydrozoans. Brachyury1 and 2 display a conservative expression pattern
marking the oral pole of the body axis in D. pumila. On the contrary, Brachyury3
expression was detected in scattered presumably nerve cells of the D. pumila larva.
Pharmacological modulations indicated that Brachyury3 is not under regulation
of cWnt signaling in contrast to the other two Brachyury genes. Divergence in
expression patterns and regulation suggest neofunctionalization of Brachyury3
in hydrozoans.
acknowledgement: "We thank N.A. Pertsov White Sea Biological Station of Moscow State
University for the help and support in obtaining samples and providing access to
all required facilities and equipment of the “Center of Microscopy WSBS MSU”. We
are grateful to Dr. Amro Hamdoun for pCS2+8 plasmid (Addgene plasmid # 34931).\r\nWork
in the Walentek lab is supported by the Deutsche Forschungsgemeinschaft (DFG) under
the Emmy Noether Programme (grant WA3365/2-2) and under Germany’s Excellence Strategy
(CIBSS-EXC-2189-Project ID 390939984). SK is supported by the project No. 0088-2021-0009
of the Koltzov Institute of Developmental Biology of the RAS. The study of molecular
patterning of D. pumila colony was funded by RFBR, project number 20-04-00978a (to
S.K.)."
article_number: '9382'
article_processing_charge: No
article_type: original
author:
- first_name: Alexandra A.
full_name: Vetrova, Alexandra A.
last_name: Vetrova
- first_name: Daria M.
full_name: Kupaeva, Daria M.
last_name: Kupaeva
- first_name: Alena
full_name: Kizenko, Alena
id: a521c60b-0815-11ed-9b02-b8bd522477c8
last_name: Kizenko
- first_name: Tatiana S.
full_name: Lebedeva, Tatiana S.
last_name: Lebedeva
- first_name: Peter
full_name: Walentek, Peter
last_name: Walentek
- first_name: Nikoloz
full_name: Tsikolia, Nikoloz
last_name: Tsikolia
- first_name: Stanislav V.
full_name: Kremnyov, Stanislav V.
last_name: Kremnyov
citation:
ama: Vetrova AA, Kupaeva DM, Kizenko A, et al. The evolutionary history of Brachyury
genes in Hydrozoa involves duplications, divergence, and neofunctionalization.
Scientific Reports. 2023;13. doi:10.1038/s41598-023-35979-8
apa: Vetrova, A. A., Kupaeva, D. M., Kizenko, A., Lebedeva, T. S., Walentek, P.,
Tsikolia, N., & Kremnyov, S. V. (2023). The evolutionary history of Brachyury
genes in Hydrozoa involves duplications, divergence, and neofunctionalization.
Scientific Reports. Springer Nature. https://doi.org/10.1038/s41598-023-35979-8
chicago: Vetrova, Alexandra A., Daria M. Kupaeva, Alena Kizenko, Tatiana S. Lebedeva,
Peter Walentek, Nikoloz Tsikolia, and Stanislav V. Kremnyov. “The Evolutionary
History of Brachyury Genes in Hydrozoa Involves Duplications, Divergence, and
Neofunctionalization.” Scientific Reports. Springer Nature, 2023. https://doi.org/10.1038/s41598-023-35979-8.
ieee: A. A. Vetrova et al., “The evolutionary history of Brachyury genes
in Hydrozoa involves duplications, divergence, and neofunctionalization,” Scientific
Reports, vol. 13. Springer Nature, 2023.
ista: Vetrova AA, Kupaeva DM, Kizenko A, Lebedeva TS, Walentek P, Tsikolia N, Kremnyov
SV. 2023. The evolutionary history of Brachyury genes in Hydrozoa involves duplications,
divergence, and neofunctionalization. Scientific Reports. 13, 9382.
mla: Vetrova, Alexandra A., et al. “The Evolutionary History of Brachyury Genes
in Hydrozoa Involves Duplications, Divergence, and Neofunctionalization.” Scientific
Reports, vol. 13, 9382, Springer Nature, 2023, doi:10.1038/s41598-023-35979-8.
short: A.A. Vetrova, D.M. Kupaeva, A. Kizenko, T.S. Lebedeva, P. Walentek, N. Tsikolia,
S.V. Kremnyov, Scientific Reports 13 (2023).
date_created: 2023-06-25T22:00:46Z
date_published: 2023-06-09T00:00:00Z
date_updated: 2023-08-02T06:17:18Z
day: '09'
ddc:
- '570'
department:
- _id: GradSch
doi: 10.1038/s41598-023-35979-8
external_id:
isi:
- '001006690200045'
pmid:
- '37296138'
file:
- access_level: open_access
checksum: baddf6b2fa9adf88263d4a3b0998f0f2
content_type: application/pdf
creator: dernst
date_created: 2023-06-26T09:58:53Z
date_updated: 2023-06-26T09:58:53Z
file_id: '13170'
file_name: 2023_ScientificReports_Vetrova.pdf
file_size: 4844149
relation: main_file
success: 1
file_date_updated: 2023-06-26T09:58:53Z
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
pmid: 1
publication: Scientific Reports
publication_identifier:
eissn:
- 2045-2322
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: The evolutionary history of Brachyury genes in Hydrozoa involves duplications,
divergence, and neofunctionalization
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 13
year: '2023'
...
---
_id: '13138'
abstract:
- lang: eng
text: "We consider the spin-\r\n1\r\n2\r\n Heisenberg chain (XXX model) weakly perturbed
away from integrability by an isotropic next-to-nearest neighbor exchange interaction.
Recently, it was conjectured that this model possesses an infinite tower of quasiconserved
integrals of motion (charges) [D. Kurlov et al., Phys. Rev. B 105, 104302 (2022)].
In this work we first test this conjecture by investigating how the norm of the
adiabatic gauge potential (AGP) scales with the system size, which is known to
be a remarkably accurate measure of chaos. We find that for the perturbed XXX
chain the behavior of the AGP norm corresponds to neither an integrable nor a
chaotic regime, which supports the conjectured quasi-integrability of the model.
We then prove the conjecture and explicitly construct the infinite set of quasiconserved
charges. Our proof relies on the fact that the XXX chain perturbed by next-to-nearest
exchange interaction can be viewed as a truncation of an integrable long-range
deformation of the Heisenberg spin chain."
acknowledgement: "The numerical computations in this work were performed using QuSpin
[83, 84]. We acknowledge useful discussions with Igor Aleiner, Boris Altshuler,
Jacopo de Nardis, Anatoli Polkovnikov, and Gora Shlyapnikov. We thank Piotr Sierant
and Dario Rosa for drawing our attention to Refs. [31, 42, 46] and Ref. [47], respectively.
We are grateful to an anonymous referee for very useful comments and for drawing
our attention to Refs. [80, 81]. The work of VG is part of the DeltaITP consortium,
a program of the Netherlands Organization for Scientific\r\nResearch (NWO) funded
by the Dutch Ministry of Education, Culture and Science (OCW). VG is also partially
supported by RSF 19-71-10092. The work of AT was supported by the ERC Starting Grant
101042293 (HEPIQ). RS acknowledges support from Slovenian Research Agency (ARRS)
- research programme P1-0402. "
article_number: '184312'
article_processing_charge: No
article_type: original
author:
- first_name: Pavel
full_name: Orlov, Pavel
last_name: Orlov
- first_name: Anastasiia
full_name: Tiutiakina, Anastasiia
last_name: Tiutiakina
- first_name: Rustem
full_name: Sharipov, Rustem
last_name: Sharipov
- first_name: Elena
full_name: Petrova, Elena
id: 0ac84990-897b-11ed-a09c-f5abb56a4ede
last_name: Petrova
- first_name: Vladimir
full_name: Gritsev, Vladimir
last_name: Gritsev
- first_name: Denis V.
full_name: Kurlov, Denis V.
last_name: Kurlov
citation:
ama: Orlov P, Tiutiakina A, Sharipov R, Petrova E, Gritsev V, Kurlov DV. Adiabatic
eigenstate deformations and weak integrability breaking of Heisenberg chain. Physical
Review B. 2023;107(18). doi:10.1103/PhysRevB.107.184312
apa: Orlov, P., Tiutiakina, A., Sharipov, R., Petrova, E., Gritsev, V., & Kurlov,
D. V. (2023). Adiabatic eigenstate deformations and weak integrability breaking
of Heisenberg chain. Physical Review B. American Physical Society. https://doi.org/10.1103/PhysRevB.107.184312
chicago: Orlov, Pavel, Anastasiia Tiutiakina, Rustem Sharipov, Elena Petrova, Vladimir
Gritsev, and Denis V. Kurlov. “Adiabatic Eigenstate Deformations and Weak Integrability
Breaking of Heisenberg Chain.” Physical Review B. American Physical Society,
2023. https://doi.org/10.1103/PhysRevB.107.184312.
ieee: P. Orlov, A. Tiutiakina, R. Sharipov, E. Petrova, V. Gritsev, and D. V. Kurlov,
“Adiabatic eigenstate deformations and weak integrability breaking of Heisenberg
chain,” Physical Review B, vol. 107, no. 18. American Physical Society,
2023.
ista: Orlov P, Tiutiakina A, Sharipov R, Petrova E, Gritsev V, Kurlov DV. 2023.
Adiabatic eigenstate deformations and weak integrability breaking of Heisenberg
chain. Physical Review B. 107(18), 184312.
mla: Orlov, Pavel, et al. “Adiabatic Eigenstate Deformations and Weak Integrability
Breaking of Heisenberg Chain.” Physical Review B, vol. 107, no. 18, 184312,
American Physical Society, 2023, doi:10.1103/PhysRevB.107.184312.
short: P. Orlov, A. Tiutiakina, R. Sharipov, E. Petrova, V. Gritsev, D.V. Kurlov,
Physical Review B 107 (2023).
date_created: 2023-06-18T22:00:46Z
date_published: 2023-05-01T00:00:00Z
date_updated: 2023-08-02T06:16:02Z
day: '01'
department:
- _id: GradSch
doi: 10.1103/PhysRevB.107.184312
external_id:
arxiv:
- '2303.00729'
isi:
- '001003686900004'
intvolume: ' 107'
isi: 1
issue: '18'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2303.00729
month: '05'
oa: 1
oa_version: Preprint
publication: Physical Review B
publication_identifier:
eissn:
- 2469-9969
issn:
- 2469-9950
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Adiabatic eigenstate deformations and weak integrability breaking of Heisenberg
chain
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 107
year: '2023'
...
---
_id: '12781'
abstract:
- lang: eng
text: "Most energy in humans is produced in form of ATP by the mitochondrial respiratory
chain consisting of several protein assemblies embedded into lipid membrane (complexes
I-V). Complex I is the first and the largest enzyme of the respiratory chain which
is essential for energy production. It couples the transfer of two electrons from
NADH to ubiquinone with proton translocation across bacterial or inner mitochondrial
membrane. The coupling mechanism between electron transfer and proton translocation
is one of the biggest enigma in bioenergetics and structural biology. Even though
the enzyme has been studied for decades, only recent technological advances in
cryo-EM allowed its extensive structural investigation. \r\n\r\nComplex I from
E.coli appears to be of special importance because it is a perfect model system
with a rich mutant library, however the structure of the entire complex was unknown.
In this thesis I have resolved structures of the minimal complex I version from
E. coli in different states including reduced, inhibited, under reaction turnover
and several others. Extensive structural analyses of these structures and comparison
to structures from other species allowed to derive general features of conformational
dynamics and propose a universal coupling mechanism. The mechanism is straightforward,
robust and consistent with decades of experimental data available for complex
I from different species. \r\n\r\nCyanobacterial NDH (cyanobacterial complex I)
is a part of broad complex I superfamily and was studied as well in this thesis.
It plays an important role in cyclic electron transfer (CET), during which electrons
are cycled within PSI through ferredoxin and plastoquinone to generate proton
gradient without NADPH production. Here, I solved structure of NDH and revealed
additional state, which was not observed before. The novel “resting” state allowed
to propose the mechanism of CET regulation. Moreover, conformational dynamics
of NDH resembles one in complex I which suggest more broad universality of the
proposed coupling mechanism.\r\n\r\nIn summary, results presented here helped
to interpret decades of experimental data for complex I and contributed to fundamental
mechanistic understanding of protein function.\r\n"
acknowledged_ssus:
- _id: EM-Fac
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Vladyslav
full_name: Kravchuk, Vladyslav
id: 4D62F2A6-F248-11E8-B48F-1D18A9856A87
last_name: Kravchuk
citation:
ama: Kravchuk V. Structural and mechanistic study of bacterial complex I and its
cyanobacterial ortholog. 2023. doi:10.15479/at:ista:12781
apa: Kravchuk, V. (2023). Structural and mechanistic study of bacterial complex
I and its cyanobacterial ortholog. Institute of Science and Technology Austria.
https://doi.org/10.15479/at:ista:12781
chicago: Kravchuk, Vladyslav. “Structural and Mechanistic Study of Bacterial Complex
I and Its Cyanobacterial Ortholog.” Institute of Science and Technology Austria,
2023. https://doi.org/10.15479/at:ista:12781.
ieee: V. Kravchuk, “Structural and mechanistic study of bacterial complex I and
its cyanobacterial ortholog,” Institute of Science and Technology Austria, 2023.
ista: Kravchuk V. 2023. Structural and mechanistic study of bacterial complex I
and its cyanobacterial ortholog. Institute of Science and Technology Austria.
mla: Kravchuk, Vladyslav. Structural and Mechanistic Study of Bacterial Complex
I and Its Cyanobacterial Ortholog. Institute of Science and Technology Austria,
2023, doi:10.15479/at:ista:12781.
short: V. Kravchuk, Structural and Mechanistic Study of Bacterial Complex I and
Its Cyanobacterial Ortholog, Institute of Science and Technology Austria, 2023.
date_created: 2023-03-31T12:24:42Z
date_published: 2023-03-23T00:00:00Z
date_updated: 2023-08-04T08:54:51Z
day: '23'
ddc:
- '570'
- '572'
degree_awarded: PhD
department:
- _id: GradSch
- _id: LeSa
doi: 10.15479/at:ista:12781
ec_funded: 1
file:
- access_level: closed
checksum: 5ebb6345cb4119f93460c81310265a6d
content_type: application/pdf
creator: vkravchu
date_created: 2023-04-19T14:33:41Z
date_updated: 2023-04-19T14:33:41Z
embargo: 2024-04-20
embargo_to: local
file_id: '12852'
file_name: VladyslavKravchuk_PhD_Thesis_PostSub_Final_1.pdf
file_size: 6071553
relation: main_file
- access_level: closed
checksum: c12055c48411d030d2afa51de2166221
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: vkravchu
date_created: 2023-04-19T14:33:52Z
date_updated: 2023-04-20T07:02:59Z
embargo: 2024-04-20
embargo_to: local
file_id: '12853'
file_name: VladyslavKravchuk_PhD_Thesis_PostSub_Final.docx
file_size: 19468766
relation: source_file
file_date_updated: 2023-04-20T07:02:59Z
has_accepted_license: '1'
language:
- iso: eng
month: '03'
oa_version: Published Version
page: '127'
project:
- _id: 238A0A5A-32DE-11EA-91FC-C7463DDC885E
grant_number: '25541'
name: 'Structural characterization of E. coli complex I: an important mechanistic
model'
- _id: 627abdeb-2b32-11ec-9570-ec31a97243d3
call_identifier: H2020
grant_number: '101020697'
name: Structure and mechanism of respiratory chain molecular machines
publication_identifier:
isbn:
- 978-3-99078-029-9
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '12138'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Leonid A
full_name: Sazanov, Leonid A
id: 338D39FE-F248-11E8-B48F-1D18A9856A87
last_name: Sazanov
orcid: 0000-0002-0977-7989
title: Structural and mechanistic study of bacterial complex I and its cyanobacterial
ortholog
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '13074'
abstract:
- lang: eng
text: "Deep learning has become an integral part of a large number of important
applications, and many of the recent breakthroughs have been enabled by the ability
to train very large models, capable to capture complex patterns and relationships
from the data. At the same time, the massive sizes of modern deep learning models
have made their deployment to smaller devices more challenging; this is particularly
important, as in many applications the users rely on accurate deep learning predictions,
but they only have access to devices with limited memory and compute power. One
solution to this problem is to prune neural networks, by setting as many of their
parameters as possible to zero, to obtain accurate sparse models with lower memory
footprint. Despite the great research progress in obtaining sparse models that
preserve accuracy, while satisfying memory and computational constraints, there
are still many challenges associated with efficiently training sparse models,
as well as understanding their generalization properties.\r\n\r\nThe focus of
this thesis is to investigate how the training process of sparse models can be
made more efficient, and to understand the differences between sparse and dense
models in terms of how well they can generalize to changes in the data distribution.
We first study a method for co-training sparse and dense models, at a lower cost
compared to regular training. With our method we can obtain very accurate sparse
networks, and dense models that can recover the baseline accuracy. Furthermore,
we are able to more easily analyze the differences, at prediction level, between
the sparse-dense model pairs. Next, we investigate the generalization properties
of sparse neural networks in more detail, by studying how well different sparse
models trained on a larger task can adapt to smaller, more specialized tasks,
in a transfer learning scenario. Our analysis across multiple pruning methods
and sparsity levels reveals that sparse models provide features that can transfer
similarly to or better than the dense baseline. However, the choice of the pruning
method plays an important role, and can influence the results when the features
are fixed (linear finetuning), or when they are allowed to adapt to the new task
(full finetuning). Using sparse models with fixed masks for finetuning on new
tasks has an important practical advantage, as it enables training neural networks
on smaller devices. However, one drawback of current pruning methods is that the
entire training cycle has to be repeated to obtain the initial sparse model, for
every sparsity target; in consequence, the entire training process is costly and
also multiple models need to be stored. In the last part of the thesis we propose
a method that can train accurate dense models that are compressible in a single
step, to multiple sparsity levels, without additional finetuning. Our method results
in sparse models that can be competitive with existing pruning methods, and which
can also successfully generalize to new tasks."
acknowledged_ssus:
- _id: ScienComp
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Elena-Alexandra
full_name: Peste, Elena-Alexandra
id: 32D78294-F248-11E8-B48F-1D18A9856A87
last_name: Peste
citation:
ama: Peste E-A. Efficiency and generalization of sparse neural networks. 2023. doi:10.15479/at:ista:13074
apa: Peste, E.-A. (2023). Efficiency and generalization of sparse neural networks.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:13074
chicago: Peste, Elena-Alexandra. “Efficiency and Generalization of Sparse Neural
Networks.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:13074.
ieee: E.-A. Peste, “Efficiency and generalization of sparse neural networks,” Institute
of Science and Technology Austria, 2023.
ista: Peste E-A. 2023. Efficiency and generalization of sparse neural networks.
Institute of Science and Technology Austria.
mla: Peste, Elena-Alexandra. Efficiency and Generalization of Sparse Neural Networks.
Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:13074.
short: E.-A. Peste, Efficiency and Generalization of Sparse Neural Networks, Institute
of Science and Technology Austria, 2023.
date_created: 2023-05-23T17:07:53Z
date_published: 2023-05-23T00:00:00Z
date_updated: 2023-08-04T10:33:27Z
day: '23'
ddc:
- '000'
degree_awarded: PhD
department:
- _id: GradSch
- _id: DaAl
- _id: ChLa
doi: 10.15479/at:ista:13074
ec_funded: 1
file:
- access_level: open_access
checksum: 6b3354968403cb9d48cc5a83611fb571
content_type: application/pdf
creator: epeste
date_created: 2023-05-24T16:11:16Z
date_updated: 2023-05-24T16:11:16Z
file_id: '13087'
file_name: PhD_Thesis_Alexandra_Peste_final.pdf
file_size: 2152072
relation: main_file
success: 1
- access_level: closed
checksum: 8d0df94bbcf4db72c991f22503b3fd60
content_type: application/zip
creator: epeste
date_created: 2023-05-24T16:12:59Z
date_updated: 2023-05-24T16:12:59Z
file_id: '13088'
file_name: PhD_Thesis_APeste.zip
file_size: 1658293
relation: source_file
file_date_updated: 2023-05-24T16:12:59Z
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: '147'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 268A44D6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '805223'
name: Elastic Coordination for Scalable Machine Learning
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '11458'
relation: part_of_dissertation
status: public
- id: '13053'
relation: part_of_dissertation
status: public
- id: '12299'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
title: Efficiency and generalization of sparse neural networks
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12964'
abstract:
- lang: eng
text: "Pattern formation is of great importance for its contribution across different
biological behaviours. During developmental processes for example, patterns of
chemical gradients are\r\nestablished to determine cell fate and complex tissue
patterns emerge to define structures such\r\nas limbs and vascular networks. Patterns
are also seen in collectively migrating groups, for\r\ninstance traveling waves
of density emerging in moving animal flocks as well as collectively migrating
cells and tissues. To what extent these biological patterns arise spontaneously
through\r\nthe local interaction of individual constituents or are dictated by
higher level instructions is\r\nstill an open question however there is evidence
for the involvement of both types of process.\r\nWhere patterns arise spontaneously
there is a long standing interest in how far the interplay\r\nof mechanics, e.g.
force generation and deformation, and chemistry, e.g. gene regulation\r\nand signaling,
contributes to the behaviour. This is because many systems are able to both\r\nchemically
regulate mechanical force production and chemically sense mechanical deformation,\r\nforming
mechano-chemical feedback loops which can potentially become unstable towards\r\nspatio
and/or temporal patterning.\r\nWe work with experimental collaborators to investigate
the possibility that this type of\r\ninteraction drives pattern formation in biological
systems at different scales. We focus first on\r\ntissue-level ERK-density waves
observed during the wound healing response across different\r\nsystems where many
previous studies have proposed that patterns depend on polarized cell\r\nmigration
and arise from a mechanical flocking-like mechanism. By combining theory with\r\nmechanical
and optogenetic perturbation experiments on in vitro monolayers we instead find\r\nevidence
for mechanochemical pattern formation involving only scalar bilateral feedbacks\r\nbetween
ERK signaling and cell contraction. We perform further modeling and experiment\r\nto
study how this instability couples with polar cell migration in order to produce
a robust\r\nand efficient wound healing response. In a following chapter we implement
ERK-density\r\ncoupling and cell migration in a 2D active vertex model to investigate
the interaction of\r\nERK-density patterning with different tissue rheologies
and find that the spatio-temporal\r\ndynamics are able to both locally and globally
fluidize a tissue across the solid-fluid glass\r\ntransition. In a last chapter
we move towards lower spatial scales in the context of subcellular\r\npatterning
of the cell cytoskeleton where we investigate the transition between phases of\r\nspatially
homogeneous temporal oscillations and chaotic spatio-temporal patterning in the\r\ndynamics
of myosin and ROCK activities (a motor component of the actomyosin cytoskeleton\r\nand
its activator). Experimental evidence supports an intrinsic chemical oscillator
which we\r\nencode in a reaction model and couple to a contractile active gel
description of the cell cortex.\r\nThe model exhibits phases of chemical oscillations
and contractile spatial patterning which\r\nreproduce many features of the dynamics
seen in Drosophila oocyte epithelia in vivo. However,\r\nadditional pharmacological
perturbations to inhibit myosin contractility leaves the role of\r\ncontractile
instability unclear. We discuss alternative hypotheses and investigate the possibility\r\nof
reaction-diffusion instability."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Daniel R
full_name: Boocock, Daniel R
id: 453AF628-F248-11E8-B48F-1D18A9856A87
last_name: Boocock
orcid: 0000-0002-1585-2631
citation:
ama: Boocock DR. Mechanochemical pattern formation across biological scales. 2023.
doi:10.15479/at:ista:12964
apa: Boocock, D. R. (2023). Mechanochemical pattern formation across biological
scales. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12964
chicago: Boocock, Daniel R. “Mechanochemical Pattern Formation across Biological
Scales.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:12964.
ieee: D. R. Boocock, “Mechanochemical pattern formation across biological scales,”
Institute of Science and Technology Austria, 2023.
ista: Boocock DR. 2023. Mechanochemical pattern formation across biological scales.
Institute of Science and Technology Austria.
mla: Boocock, Daniel R. Mechanochemical Pattern Formation across Biological Scales.
Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:12964.
short: D.R. Boocock, Mechanochemical Pattern Formation across Biological Scales,
Institute of Science and Technology Austria, 2023.
date_created: 2023-05-15T14:52:36Z
date_published: 2023-05-17T00:00:00Z
date_updated: 2023-08-04T11:02:40Z
day: '17'
ddc:
- '530'
degree_awarded: PhD
department:
- _id: GradSch
- _id: EdHa
doi: 10.15479/at:ista:12964
ec_funded: 1
file:
- access_level: closed
checksum: d51240675fc6dc0e3f5dc0c902695d3a
content_type: application/pdf
creator: dboocock
date_created: 2023-05-17T13:39:54Z
date_updated: 2023-05-19T07:04:25Z
embargo: 2024-05-17
embargo_to: open_access
file_id: '12988'
file_name: thesis_boocock.pdf
file_size: 40414730
relation: main_file
- access_level: closed
checksum: 581a2313ffeb40fe77e8a122a25a7795
content_type: application/zip
creator: dboocock
date_created: 2023-05-17T13:39:53Z
date_updated: 2023-05-17T14:35:13Z
file_id: '12989'
file_name: thesis_boocock.zip
file_size: 34338567
relation: source_file
file_date_updated: 2023-05-19T07:04:25Z
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa_version: Published Version
page: '146'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
isbn:
- 978-3-99078-032-9
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8602'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
title: Mechanochemical pattern formation across biological scales
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12885'
abstract:
- lang: eng
text: 'High-performance semiconductors rely upon precise control of heat and charge
transport. This can be achieved by precisely engineering defects in polycrystalline
solids. There are multiple approaches to preparing such polycrystalline semiconductors,
and the transformation of solution-processed colloidal nanoparticles is appealing
because colloidal nanoparticles combine low cost with structural and compositional
tunability along with rich surface chemistry. However, the multiple processes
from nanoparticle synthesis to the final bulk nanocomposites are very complex.
They involve nanoparticle purification, post-synthetic modifications, and finally
consolidation (thermal treatments and densification). All these properties dictate
the final material’s composition and microstructure, ultimately affecting its
functional properties. This thesis explores the synthesis, surface chemistry and
consolidation of colloidal semiconductor nanoparticles into dense solids. In particular,
the transformations that take place during these processes, and their effect on
the material’s transport properties are evaluated. '
acknowledged_ssus:
- _id: EM-Fac
- _id: NanoFab
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Mariano
full_name: Calcabrini, Mariano
id: 45D7531A-F248-11E8-B48F-1D18A9856A87
last_name: Calcabrini
orcid: 0000-0003-4566-5877
citation:
ama: 'Calcabrini M. Nanoparticle-based semiconductor solids: From synthesis to consolidation.
2023. doi:10.15479/at:ista:12885'
apa: 'Calcabrini, M. (2023). Nanoparticle-based semiconductor solids: From synthesis
to consolidation. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12885'
chicago: 'Calcabrini, Mariano. “Nanoparticle-Based Semiconductor Solids: From Synthesis
to Consolidation.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:12885.'
ieee: 'M. Calcabrini, “Nanoparticle-based semiconductor solids: From synthesis to
consolidation,” Institute of Science and Technology Austria, 2023.'
ista: 'Calcabrini M. 2023. Nanoparticle-based semiconductor solids: From synthesis
to consolidation. Institute of Science and Technology Austria.'
mla: 'Calcabrini, Mariano. Nanoparticle-Based Semiconductor Solids: From Synthesis
to Consolidation. Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:12885.'
short: 'M. Calcabrini, Nanoparticle-Based Semiconductor Solids: From Synthesis to
Consolidation, Institute of Science and Technology Austria, 2023.'
date_created: 2023-05-02T07:58:57Z
date_published: 2023-04-28T00:00:00Z
date_updated: 2023-08-14T07:25:26Z
day: '28'
ddc:
- '546'
- '541'
degree_awarded: PhD
department:
- _id: GradSch
- _id: MaIb
doi: 10.15479/at:ista:12885
ec_funded: 1
file:
- access_level: closed
checksum: 9347b0e09425f56fdcede5d3528404dc
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: mcalcabr
date_created: 2023-05-02T07:43:18Z
date_updated: 2023-05-02T07:43:18Z
file_id: '12887'
file_name: Thesis_Calcabrini.docx
file_size: 99627036
relation: source_file
- access_level: open_access
checksum: 2d188b76621086cd384f0b9264b0a576
content_type: application/pdf
creator: mcalcabr
date_created: 2023-05-02T07:42:45Z
date_updated: 2023-05-02T07:42:45Z
file_id: '12888'
file_name: Thesis_Calcabrini_pdfa.pdf
file_size: 8742220
relation: main_file
success: 1
file_date_updated: 2023-05-02T07:43:18Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: '82'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
isbn:
- 978-3-99078-028-2
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '10806'
relation: part_of_dissertation
status: public
- id: '10042'
relation: part_of_dissertation
status: public
- id: '12237'
relation: part_of_dissertation
status: public
- id: '9118'
relation: part_of_dissertation
status: public
- id: '10123'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Maria
full_name: Ibáñez, Maria
id: 43C61214-F248-11E8-B48F-1D18A9856A87
last_name: Ibáñez
orcid: 0000-0001-5013-2843
title: 'Nanoparticle-based semiconductor solids: From synthesis to consolidation'
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12521'
abstract:
- lang: eng
text: Differentiated X chromosomes are expected to have higher rates of adaptive
divergence than autosomes, if new beneficial mutations are recessive (the “faster-X
effect”), largely because these mutations are immediately exposed to selection
in males. The evolution of X chromosomes after they stop recombining in males,
but before they become hemizygous, has not been well explored theoretically. We
use the diffusion approximation to infer substitution rates of beneficial and
deleterious mutations under such a scenario. Our results show that selection is
less efficient on diploid X loci than on autosomal and hemizygous X loci under
a wide range of parameters. This “slower-X” effect is stronger for genes affecting
primarily (or only) male fitness, and for sexually antagonistic genes. These unusual
dynamics suggest that some of the peculiar features of X chromosomes, such as
the differential accumulation of genes with sex-specific functions, may start
arising earlier than previously appreciated.
acknowledgement: We thank the Vicoso and Barton groups and ISTA Scientific Computing
Unit. We also thank two anonymous reviewers for their valuable comments. This work
was supported by the European Research Council under the European Union’s Horizon
2020 research and innovation program (grant agreements no. 715257 and no. 716117).
article_number: qrac004
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Andrea
full_name: Mrnjavac, Andrea
id: 353FAC84-AE61-11E9-8BFC-00D3E5697425
last_name: Mrnjavac
- first_name: Kseniia
full_name: Khudiakova, Kseniia
id: 4E6DC800-AE37-11E9-AC72-31CAE5697425
last_name: Khudiakova
orcid: 0000-0002-6246-1465
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
citation:
ama: 'Mrnjavac A, Khudiakova K, Barton NH, Vicoso B. Slower-X: Reduced efficiency
of selection in the early stages of X chromosome evolution. Evolution Letters.
2023;7(1). doi:10.1093/evlett/qrac004'
apa: 'Mrnjavac, A., Khudiakova, K., Barton, N. H., & Vicoso, B. (2023). Slower-X:
Reduced efficiency of selection in the early stages of X chromosome evolution.
Evolution Letters. Oxford University Press. https://doi.org/10.1093/evlett/qrac004'
chicago: 'Mrnjavac, Andrea, Kseniia Khudiakova, Nicholas H Barton, and Beatriz Vicoso.
“Slower-X: Reduced Efficiency of Selection in the Early Stages of X Chromosome
Evolution.” Evolution Letters. Oxford University Press, 2023. https://doi.org/10.1093/evlett/qrac004.'
ieee: 'A. Mrnjavac, K. Khudiakova, N. H. Barton, and B. Vicoso, “Slower-X: Reduced
efficiency of selection in the early stages of X chromosome evolution,” Evolution
Letters, vol. 7, no. 1. Oxford University Press, 2023.'
ista: 'Mrnjavac A, Khudiakova K, Barton NH, Vicoso B. 2023. Slower-X: Reduced efficiency
of selection in the early stages of X chromosome evolution. Evolution Letters.
7(1), qrac004.'
mla: 'Mrnjavac, Andrea, et al. “Slower-X: Reduced Efficiency of Selection in the
Early Stages of X Chromosome Evolution.” Evolution Letters, vol. 7, no.
1, qrac004, Oxford University Press, 2023, doi:10.1093/evlett/qrac004.'
short: A. Mrnjavac, K. Khudiakova, N.H. Barton, B. Vicoso, Evolution Letters 7 (2023).
date_created: 2023-02-06T13:59:12Z
date_published: 2023-02-01T00:00:00Z
date_updated: 2023-08-16T11:44:32Z
day: '01'
ddc:
- '570'
department:
- _id: GradSch
- _id: BeVi
doi: 10.1093/evlett/qrac004
ec_funded: 1
external_id:
isi:
- '001021692200001'
pmid:
- '37065438'
file:
- access_level: open_access
checksum: a240a041cb9b9b7c8ba93a4706674a3f
content_type: application/pdf
creator: dernst
date_created: 2023-08-16T11:43:33Z
date_updated: 2023-08-16T11:43:33Z
file_id: '14068'
file_name: 2023_EvLetters_Mrnjavac.pdf
file_size: 2592189
relation: main_file
success: 1
file_date_updated: 2023-08-16T11:43:33Z
has_accepted_license: '1'
intvolume: ' 7'
isi: 1
issue: '1'
keyword:
- Genetics
- Ecology
- Evolution
- Behavior and Systematics
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 256E75B8-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '716117'
name: Optimal Transport and Stochastic Dynamics
- _id: 250BDE62-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715257'
name: Prevalence and Influence of Sexual Antagonism on Genome Evolution
publication: Evolution Letters
publication_identifier:
issn:
- 2056-3744
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Slower-X: Reduced efficiency of selection in the early stages of X chromosome
evolution'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7
year: '2023'
...
---
_id: '12762'
abstract:
- lang: eng
text: Neurons in the brain are wired into adaptive networks that exhibit collective
dynamics as diverse as scale-specific oscillations and scale-free neuronal avalanches.
Although existing models account for oscillations and avalanches separately, they
typically do not explain both phenomena, are too complex to analyze analytically
or intractable to infer from data rigorously. Here we propose a feedback-driven
Ising-like class of neural networks that captures avalanches and oscillations
simultaneously and quantitatively. In the simplest yet fully microscopic model
version, we can analytically compute the phase diagram and make direct contact
with human brain resting-state activity recordings via tractable inference of
the model’s two essential parameters. The inferred model quantitatively captures
the dynamics over a broad range of scales, from single sensor oscillations to
collective behaviors of extreme events and neuronal avalanches. Importantly, the
inferred parameters indicate that the co-existence of scale-specific (oscillations)
and scale-free (avalanches) dynamics occurs close to a non-equilibrium critical
point at the onset of self-sustained oscillations.
acknowledgement: This research was funded in whole, or in part, by the Austrian Science
Fund (FWF) (grant no. PT1013M03318 to F.L. and no. P34015 to G.T.). For the purpose
of open access, the author has applied a CC BY public copyright licence to any Author
Accepted Manuscript version arising from this submission. The study was supported
by the European Union Horizon 2020 research and innovation program under the Marie
Sklodowska-Curie action (grant agreement No. 754411 to F.L.).
article_processing_charge: No
article_type: original
author:
- first_name: Fabrizio
full_name: Lombardi, Fabrizio
id: A057D288-3E88-11E9-986D-0CF4E5697425
last_name: Lombardi
orcid: 0000-0003-2623-5249
- first_name: Selver
full_name: Pepic, Selver
id: F93245C4-C3CA-11E9-B4F0-C6F4E5697425
last_name: Pepic
- first_name: Oren
full_name: Shriki, Oren
last_name: Shriki
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- first_name: Daniele
full_name: De Martino, Daniele
id: 3FF5848A-F248-11E8-B48F-1D18A9856A87
last_name: De Martino
orcid: 0000-0002-5214-4706
citation:
ama: Lombardi F, Pepic S, Shriki O, Tkačik G, De Martino D. Statistical modeling
of adaptive neural networks explains co-existence of avalanches and oscillations
in resting human brain. Nature Computational Science. 2023;3:254-263. doi:10.1038/s43588-023-00410-9
apa: Lombardi, F., Pepic, S., Shriki, O., Tkačik, G., & De Martino, D. (2023).
Statistical modeling of adaptive neural networks explains co-existence of avalanches
and oscillations in resting human brain. Nature Computational Science.
Springer Nature. https://doi.org/10.1038/s43588-023-00410-9
chicago: Lombardi, Fabrizio, Selver Pepic, Oren Shriki, Gašper Tkačik, and Daniele
De Martino. “Statistical Modeling of Adaptive Neural Networks Explains Co-Existence
of Avalanches and Oscillations in Resting Human Brain.” Nature Computational
Science. Springer Nature, 2023. https://doi.org/10.1038/s43588-023-00410-9.
ieee: F. Lombardi, S. Pepic, O. Shriki, G. Tkačik, and D. De Martino, “Statistical
modeling of adaptive neural networks explains co-existence of avalanches and oscillations
in resting human brain,” Nature Computational Science, vol. 3. Springer
Nature, pp. 254–263, 2023.
ista: Lombardi F, Pepic S, Shriki O, Tkačik G, De Martino D. 2023. Statistical modeling
of adaptive neural networks explains co-existence of avalanches and oscillations
in resting human brain. Nature Computational Science. 3, 254–263.
mla: Lombardi, Fabrizio, et al. “Statistical Modeling of Adaptive Neural Networks
Explains Co-Existence of Avalanches and Oscillations in Resting Human Brain.”
Nature Computational Science, vol. 3, Springer Nature, 2023, pp. 254–63,
doi:10.1038/s43588-023-00410-9.
short: F. Lombardi, S. Pepic, O. Shriki, G. Tkačik, D. De Martino, Nature Computational
Science 3 (2023) 254–263.
date_created: 2023-03-26T22:01:08Z
date_published: 2023-03-20T00:00:00Z
date_updated: 2023-08-16T12:41:53Z
day: '20'
ddc:
- '570'
department:
- _id: GaTk
- _id: GradSch
doi: 10.1038/s43588-023-00410-9
ec_funded: 1
external_id:
arxiv:
- '2108.06686'
file:
- access_level: open_access
checksum: 7c63b2b2edfd68aaffe96d70ca6a865a
content_type: application/pdf
creator: dernst
date_created: 2023-08-16T12:39:57Z
date_updated: 2023-08-16T12:39:57Z
file_id: '14073'
file_name: 2023_NatureCompScience_Lombardi.pdf
file_size: 4474284
relation: main_file
success: 1
file_date_updated: 2023-08-16T12:39:57Z
has_accepted_license: '1'
intvolume: ' 3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 254-263
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: eb943429-77a9-11ec-83b8-9f471cdf5c67
grant_number: M03318
name: Functional Advantages of Critical Brain Dynamics
- _id: 626c45b5-2b32-11ec-9570-e509828c1ba6
grant_number: P34015
name: Efficient coding with biophysical realism
publication: Nature Computational Science
publication_identifier:
eissn:
- 2662-8457
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Statistical modeling of adaptive neural networks explains co-existence of avalanches
and oscillations in resting human brain
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 3
year: '2023'
...
---
_id: '12891'
abstract:
- lang: eng
text: "The tight spatiotemporal coordination of signaling activity determining embryo\r\npatterning
and the physical processes driving embryo morphogenesis renders\r\nembryonic development
robust, such that key developmental processes can unfold\r\nrelatively normally
even outside of the full embryonic context. For instance, embryonic\r\nstem cell
cultures can recapitulate the hallmarks of gastrulation, i.e. break symmetry\r\nleading
to germ layer formation and morphogenesis, in a very reduced environment.\r\nThis
leads to questions on specific contributions of embryo-specific features, such
as\r\nthe presence of extraembryonic tissues, which are inherently involved in
gastrulation\r\nin the full embryonic context. To address this, we established
zebrafish embryonic\r\nexplants without the extraembryonic yolk cell, an important
player as a signaling\r\nsource and for morphogenesis during gastrulation, as
a model of ex vivo development.\r\nWe found that dorsal-marginal determinants
are required and sufficient in these\r\nexplants to form and pattern all three
germ layers. However, formation of tissues,\r\nwhich require the highest Nodal-signaling
levels, is variable, demonstrating a\r\ncontribution of extraembryonic tissues
for reaching peak Nodal signaling levels.\r\nBlastoderm explants also undergo
gastrulation-like axis elongation. We found that this\r\nelongation movement shows
hallmarks of oriented mesendoderm cell intercalations\r\ntypically associated
with dorsal tissues in the intact embryo. These are disrupted by\r\nuniform upregulation
of BMP signaling activity and concomitant explant ventralization,\r\nsuggesting
that tight spatial control of BMP signaling is a prerequisite for explant\r\nmorphogenesis.
This control is achieved by Nodal signaling, which is critical for\r\neffectively
downregulating BMP signaling in the mesendoderm, highlighting that Nodal\r\nsignaling
is not only directly required for mesendoderm cell fate specification and\r\nmorphogenesis,
but also by maintaining low levels of BMP signaling at the dorsal side.\r\nCollectively,
we provide insights into the capacity and organization of signaling and\r\nmorphogenetic
domains to recapitulate features of zebrafish gastrulation outside of\r\nthe full
embryonic context."
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Alexandra
full_name: Schauer, Alexandra
id: 30A536BA-F248-11E8-B48F-1D18A9856A87
last_name: Schauer
orcid: 0000-0001-7659-9142
citation:
ama: 'Schauer A. Mesendoderm formation in zebrafish gastrulation: The role of extraembryonic
tissues. 2023. doi:10.15479/at:ista:12891'
apa: 'Schauer, A. (2023). Mesendoderm formation in zebrafish gastrulation: The
role of extraembryonic tissues. Institute of Science and Technology Austria.
https://doi.org/10.15479/at:ista:12891'
chicago: 'Schauer, Alexandra. “Mesendoderm Formation in Zebrafish Gastrulation:
The Role of Extraembryonic Tissues.” Institute of Science and Technology Austria,
2023. https://doi.org/10.15479/at:ista:12891.'
ieee: 'A. Schauer, “Mesendoderm formation in zebrafish gastrulation: The role of
extraembryonic tissues,” Institute of Science and Technology Austria, 2023.'
ista: 'Schauer A. 2023. Mesendoderm formation in zebrafish gastrulation: The role
of extraembryonic tissues. Institute of Science and Technology Austria.'
mla: 'Schauer, Alexandra. Mesendoderm Formation in Zebrafish Gastrulation: The
Role of Extraembryonic Tissues. Institute of Science and Technology Austria,
2023, doi:10.15479/at:ista:12891.'
short: 'A. Schauer, Mesendoderm Formation in Zebrafish Gastrulation: The Role of
Extraembryonic Tissues, Institute of Science and Technology Austria, 2023.'
date_created: 2023-05-05T08:48:20Z
date_published: 2023-05-05T00:00:00Z
date_updated: 2023-08-21T06:25:48Z
day: '05'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: CaHe
doi: 10.15479/at:ista:12891
ec_funded: 1
file:
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checksum: 59b0303dc483f40a96a610a90aab7ee9
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month: '05'
oa_version: Published Version
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project:
- _id: 260F1432-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742573'
name: Interaction and feedback between cell mechanics and fate specification in
vertebrate gastrulation
- _id: 26B1E39C-B435-11E9-9278-68D0E5697425
grant_number: '25239'
name: 'Mesendoderm specification in zebrafish: The role of extraembryonic tissues'
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
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relation: part_of_dissertation
status: public
- id: '7888'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
title: 'Mesendoderm formation in zebrafish gastrulation: The role of extraembryonic
tissues'
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '13175'
abstract:
- lang: eng
text: "About a 100 years ago, we discovered that our universe is inherently noisy,
that is, measuring any physical quantity with a precision beyond a certain point
is not possible because of an omnipresent inherent noise. We call this - the quantum
noise. Certain physical processes allow this quantum noise to get correlated in
conjugate physical variables. These quantum correlations can be used to go beyond
the potential of our inherently noisy universe and obtain a quantum advantage
over the classical applications. \r\n\r\nQuantum noise being inherent also means
that, at the fundamental level, the physical quantities are not well defined and
therefore, objects can stay in multiple states at the same time. For example,
the position of a particle not being well defined means that the particle is in
multiple positions at the same time. About 4 decades ago, we started exploring
the possibility of using objects which can be in multiple states at the same time
to increase the dimensionality in computation. Thus, the field of quantum computing
was born. We discovered that using quantum entanglement, a property closely related
to quantum correlations, can be used to speed up computation of certain problems,
such as factorisation of large numbers, faster than any known classical algorithm.
Thus began the pursuit to make quantum computers a reality. \r\n\r\nTill date,
we have explored quantum control over many physical systems including photons,
spins, atoms, ions and even simple circuits made up of superconducting material.
However, there persists one ubiquitous theme. The more readily a system interacts
with an external field or matter, the more easily we can control it. But this
also means that such a system can easily interact with a noisy environment and
quickly lose its coherence. Consequently, such systems like electron spins need
to be protected from the environment to ensure the longevity of their coherence.
Other systems like nuclear spins are naturally protected as they do not interact
easily with the environment. But, due to the same reason, it is harder to interact
with such systems. \r\n\r\nAfter decades of experimentation with various systems,
we are convinced that no one type of quantum system would be the best for all
the quantum applications. We would need hybrid systems which are all interconnected
- much like the current internet where all sorts of devices can all talk to each
other - but now for quantum devices. A quantum internet. \r\n\r\nOptical photons
are the best contenders to carry information for the quantum internet. They can
carry quantum information cheaply and without much loss - the same reasons which
has made them the backbone of our current internet. Following this direction,
many systems, like trapped ions, have already demonstrated successful quantum
links over a large distances using optical photons. However, some of the most
promising contenders for quantum computing which are based on microwave frequencies
have been left behind. This is because high energy optical photons can adversely
affect fragile low-energy microwave systems. \r\n\r\nIn this thesis, we present
substantial progress on this missing quantum link between microwave and optics
using electrooptical nonlinearities in lithium niobate. The nonlinearities are
enhanced by using resonant cavities for all the involved modes leading to observation
of strong direct coupling between optical and microwave frequencies. With this
strong coupling we are not only able to achieve almost 100\\% internal conversion
efficiency with low added noise, thus presenting a quantum-enabled transducer,
but also we are able to observe novel effects such as cooling of a microwave mode
using optics. The strong coupling regime also leads to direct observation of dynamical
backaction effect between microwave and optical frequencies which are studied
in detail here. Finally, we also report first observation of microwave-optics
entanglement in form of two-mode squeezed vacuum squeezed 0.7dB below vacuum level.
\r\nWith this new bridge between microwave and optics, the microwave-based quantum
technologies can finally be a part of a quantum network which is based on optical
photons - putting us one step closer to a future with quantum internet. "
acknowledged_ssus:
- _id: M-Shop
- _id: SSU
- _id: NanoFab
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Rishabh
full_name: Sahu, Rishabh
id: 47D26E34-F248-11E8-B48F-1D18A9856A87
last_name: Sahu
orcid: 0000-0001-6264-2162
citation:
ama: Sahu R. Cavity quantum electrooptics. 2023. doi:10.15479/at:ista:13175
apa: Sahu, R. (2023). Cavity quantum electrooptics. Institute of Science
and Technology Austria. https://doi.org/10.15479/at:ista:13175
chicago: Sahu, Rishabh. “Cavity Quantum Electrooptics.” Institute of Science and
Technology Austria, 2023. https://doi.org/10.15479/at:ista:13175.
ieee: R. Sahu, “Cavity quantum electrooptics,” Institute of Science and Technology
Austria, 2023.
ista: Sahu R. 2023. Cavity quantum electrooptics. Institute of Science and Technology
Austria.
mla: Sahu, Rishabh. Cavity Quantum Electrooptics. Institute of Science and
Technology Austria, 2023, doi:10.15479/at:ista:13175.
short: R. Sahu, Cavity Quantum Electrooptics, Institute of Science and Technology
Austria, 2023.
date_created: 2023-06-30T08:07:43Z
date_published: 2023-05-05T00:00:00Z
date_updated: 2023-08-24T11:16:35Z
day: '05'
ddc:
- '537'
- '535'
- '539'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JoFi
doi: 10.15479/at:ista:13175
ec_funded: 1
file:
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keyword:
- quantum optics
- electrooptics
- quantum networks
- quantum communication
- transduction
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: '202'
project:
- _id: 26336814-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '758053'
name: A Fiber Optic Transceiver for Superconducting Qubits
- _id: 9B868D20-BA93-11EA-9121-9846C619BF3A
call_identifier: H2020
grant_number: '899354'
name: Quantum Local Area Networks with Superconducting Qubits
- _id: bdb108fd-d553-11ed-ba76-83dc74a9864f
name: QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration
of Superconducting Quantum Circuits
publication_identifier:
isbn:
- 978-3-99078-030-5
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '12900'
relation: old_edition
status: public
- id: '10924'
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- id: '9114'
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status: public
status: public
supervisor:
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
title: Cavity quantum electrooptics
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
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short: CC BY-NC-SA (4.0)
type: dissertation
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year: '2023'
...
---
_id: '12900'
abstract:
- lang: eng
text: "About a 100 years ago, we discovered that our universe is inherently noisy,
that is, measuring any physical quantity with a precision beyond a certain point
is not possible because of an omnipresent inherent noise. We call this - the quantum
noise. Certain physical processes allow this quantum noise to get correlated in
conjugate physical variables. These quantum correlations can be used to go beyond
the potential of our inherently noisy universe and obtain a quantum advantage
over the classical applications. \r\n\r\nQuantum noise being inherent also means
that, at the fundamental level, the physical quantities are not well defined and
therefore, objects can stay in multiple states at the same time. For example,
the position of a particle not being well defined means that the particle is in
multiple positions at the same time. About 4 decades ago, we started exploring
the possibility of using objects which can be in multiple states at the same time
to increase the dimensionality in computation. Thus, the field of quantum computing
was born. We discovered that using quantum entanglement, a property closely related
to quantum correlations, can be used to speed up computation of certain problems,
such as factorisation of large numbers, faster than any known classical algorithm.
Thus began the pursuit to make quantum computers a reality. \r\n\r\nTill date,
we have explored quantum control over many physical systems including photons,
spins, atoms, ions and even simple circuits made up of superconducting material.
However, there persists one ubiquitous theme. The more readily a system interacts
with an external field or matter, the more easily we can control it. But this
also means that such a system can easily interact with a noisy environment and
quickly lose its coherence. Consequently, such systems like electron spins need
to be protected from the environment to ensure the longevity of their coherence.
Other systems like nuclear spins are naturally protected as they do not interact
easily with the environment. But, due to the same reason, it is harder to interact
with such systems. \r\n\r\nAfter decades of experimentation with various systems,
we are convinced that no one type of quantum system would be the best for all
the quantum applications. We would need hybrid systems which are all interconnected
- much like the current internet where all sorts of devices can all talk to each
other - but now for quantum devices. A quantum internet. \r\n\r\nOptical photons
are the best contenders to carry information for the quantum internet. They can
carry quantum information cheaply and without much loss - the same reasons which
has made them the backbone of our current internet. Following this direction,
many systems, like trapped ions, have already demonstrated successful quantum
links over a large distances using optical photons. However, some of the most
promising contenders for quantum computing which are based on microwave frequencies
have been left behind. This is because high energy optical photons can adversely
affect fragile low-energy microwave systems. \r\n\r\nIn this thesis, we present
substantial progress on this missing quantum link between microwave and optics
using electrooptical nonlinearities in lithium niobate. The nonlinearities are
enhanced by using resonant cavities for all the involved modes leading to observation
of strong direct coupling between optical and microwave frequencies. With this
strong coupling we are not only able to achieve almost 100\\% internal conversion
efficiency with low added noise, thus presenting a quantum-enabled transducer,
but also we are able to observe novel effects such as cooling of a microwave mode
using optics. The strong coupling regime also leads to direct observation of dynamical
backaction effect between microwave and optical frequencies which are studied
in detail here. Finally, we also report first observation of microwave-optics
entanglement in form of two-mode squeezed vacuum squeezed 0.7dB below vacuum level.
\r\nWith this new bridge between microwave and optics, the microwave-based quantum
technologies can finally be a part of a quantum network which is based on optical
photons - putting us one step closer to a future with quantum internet. "
acknowledged_ssus:
- _id: M-Shop
- _id: SSU
- _id: NanoFab
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Rishabh
full_name: Sahu, Rishabh
id: 47D26E34-F248-11E8-B48F-1D18A9856A87
last_name: Sahu
orcid: 0000-0001-6264-2162
citation:
ama: Sahu R. Cavity quantum electrooptics. 2023. doi:10.15479/at:ista:12900
apa: Sahu, R. (2023). Cavity quantum electrooptics. Institute of Science
and Technology Austria. https://doi.org/10.15479/at:ista:12900
chicago: Sahu, Rishabh. “Cavity Quantum Electrooptics.” Institute of Science and
Technology Austria, 2023. https://doi.org/10.15479/at:ista:12900.
ieee: R. Sahu, “Cavity quantum electrooptics,” Institute of Science and Technology
Austria, 2023.
ista: Sahu R. 2023. Cavity quantum electrooptics. Institute of Science and Technology
Austria.
mla: Sahu, Rishabh. Cavity Quantum Electrooptics. Institute of Science and
Technology Austria, 2023, doi:10.15479/at:ista:12900.
short: R. Sahu, Cavity Quantum Electrooptics, Institute of Science and Technology
Austria, 2023.
date_created: 2023-05-05T11:08:50Z
date_published: 2023-05-05T00:00:00Z
date_updated: 2023-08-24T11:16:35Z
day: '05'
ddc:
- '537'
- '535'
- '539'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JoFi
doi: 10.15479/at:ista:12900
ec_funded: 1
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keyword:
- quantum optics
- electrooptics
- quantum networks
- quantum communication
- transduction
language:
- iso: eng
month: '05'
oa_version: Published Version
page: '190'
project:
- _id: 26336814-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '758053'
name: A Fiber Optic Transceiver for Superconducting Qubits
- _id: 9B868D20-BA93-11EA-9121-9846C619BF3A
call_identifier: H2020
grant_number: '899354'
name: Quantum Local Area Networks with Superconducting Qubits
- _id: bdb108fd-d553-11ed-ba76-83dc74a9864f
name: QUANTUM INFORMATION SYSTEMS BEYOND CLASSICAL CAPABILITIES / P5- Integration
of Superconducting Quantum Circuits
publication_identifier:
isbn:
- 978-3-99078-030-5
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
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relation: new_edition
status: public
- id: '10924'
relation: part_of_dissertation
status: public
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relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
title: Cavity quantum electrooptics
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
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short: CC BY-NC-SA (4.0)
type: dissertation
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...
---
_id: '13310'
abstract:
- lang: eng
text: Machine-learned systems are in widespread use for making decisions about humans,
and it is important that they are fair, i.e., not biased against individuals based
on sensitive attributes. We present runtime verification of algorithmic fairness
for systems whose models are unknown, but are assumed to have a Markov chain structure.
We introduce a specification language that can model many common algorithmic fairness
properties, such as demographic parity, equal opportunity, and social burden.
We build monitors that observe a long sequence of events as generated by a given
system, and output, after each observation, a quantitative estimate of how fair
or biased the system was on that run until that point in time. The estimate is
proven to be correct modulo a variable error bound and a given confidence level,
where the error bound gets tighter as the observed sequence gets longer. Our monitors
are of two types, and use, respectively, frequentist and Bayesian statistical
inference techniques. While the frequentist monitors compute estimates that are
objectively correct with respect to the ground truth, the Bayesian monitors compute
estimates that are correct subject to a given prior belief about the system’s
model. Using a prototype implementation, we show how we can monitor if a bank
is fair in giving loans to applicants from different social backgrounds, and if
a college is fair in admitting students while maintaining a reasonable financial
burden on the society. Although they exhibit different theoretical complexities
in certain cases, in our experiments, both frequentist and Bayesian monitors took
less than a millisecond to update their verdicts after each observation.
acknowledgement: 'This work is supported by the European Research Council under Grant
No.: ERC-2020-AdG101020093.'
alternative_title:
- LNCS
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
- first_name: Mahyar
full_name: Karimi, Mahyar
id: f1dedef5-2f78-11ee-989a-c4c97bccf506
last_name: Karimi
orcid: 0009-0005-0820-1696
- first_name: Konstantin
full_name: Kueffner, Konstantin
id: 8121a2d0-dc85-11ea-9058-af578f3b4515
last_name: Kueffner
orcid: 0000-0001-8974-2542
- first_name: Kaushik
full_name: Mallik, Kaushik
id: 0834ff3c-6d72-11ec-94e0-b5b0a4fb8598
last_name: Mallik
orcid: 0000-0001-9864-7475
citation:
ama: 'Henzinger TA, Karimi M, Kueffner K, Mallik K. Monitoring algorithmic fairness.
In: Computer Aided Verification. Vol 13965. Springer Nature; 2023:358–382.
doi:10.1007/978-3-031-37703-7_17'
apa: 'Henzinger, T. A., Karimi, M., Kueffner, K., & Mallik, K. (2023). Monitoring
algorithmic fairness. In Computer Aided Verification (Vol. 13965, pp. 358–382).
Paris, France: Springer Nature. https://doi.org/10.1007/978-3-031-37703-7_17'
chicago: Henzinger, Thomas A, Mahyar Karimi, Konstantin Kueffner, and Kaushik Mallik.
“Monitoring Algorithmic Fairness.” In Computer Aided Verification, 13965:358–382.
Springer Nature, 2023. https://doi.org/10.1007/978-3-031-37703-7_17.
ieee: T. A. Henzinger, M. Karimi, K. Kueffner, and K. Mallik, “Monitoring algorithmic
fairness,” in Computer Aided Verification, Paris, France, 2023, vol. 13965,
pp. 358–382.
ista: 'Henzinger TA, Karimi M, Kueffner K, Mallik K. 2023. Monitoring algorithmic
fairness. Computer Aided Verification. CAV: Computer Aided Verification, LNCS,
vol. 13965, 358–382.'
mla: Henzinger, Thomas A., et al. “Monitoring Algorithmic Fairness.” Computer
Aided Verification, vol. 13965, Springer Nature, 2023, pp. 358–382, doi:10.1007/978-3-031-37703-7_17.
short: T.A. Henzinger, M. Karimi, K. Kueffner, K. Mallik, in:, Computer Aided Verification,
Springer Nature, 2023, pp. 358–382.
conference:
end_date: 2023-07-22
location: Paris, France
name: 'CAV: Computer Aided Verification'
start_date: 2023-07-17
date_created: 2023-07-25T18:32:40Z
date_published: 2023-07-18T00:00:00Z
date_updated: 2023-09-05T15:14:00Z
day: '18'
ddc:
- '000'
department:
- _id: GradSch
- _id: ToHe
doi: 10.1007/978-3-031-37703-7_17
ec_funded: 1
external_id:
arxiv:
- '2305.15979'
file:
- access_level: open_access
checksum: ccaf94bf7d658ba012c016e11869b54c
content_type: application/pdf
creator: dernst
date_created: 2023-07-31T08:11:20Z
date_updated: 2023-07-31T08:11:20Z
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success: 1
file_date_updated: 2023-07-31T08:11:20Z
has_accepted_license: '1'
intvolume: ' 13965'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 358–382
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
call_identifier: H2020
grant_number: '101020093'
name: Vigilant Algorithmic Monitoring of Software
publication: Computer Aided Verification
publication_identifier:
eisbn:
- '9783031377037'
eissn:
- 1611-3349
isbn:
- '9783031377020'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
status: public
title: Monitoring algorithmic fairness
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 13965
year: '2023'
...
---
_id: '14261'
abstract:
- lang: eng
text: In this work, a generalized, adapted Numerov implementation capable of determining
band structures of periodic quantum systems is outlined. Based on the input potential,
the presented approach numerically solves the Schrödinger equation in position
space at each momentum space point. Thus, in addition to the band structure, the
method inherently provides information about the state functions and probability
densities in position space at each momentum space point considered. The generalized,
adapted Numerov framework provided reliable estimates for a variety of increasingly
complex test suites in one, two, and three dimensions. The accuracy of the proposed
methodology was benchmarked against results obtained for the analytically solvable
Kronig-Penney model. Furthermore, the presented numerical solver was applied to
a model potential representing a 2D optical lattice being a challenging application
relevant, for example, in the field of quantum computing.
acknowledgement: Financial supports for this work via a PhD scholarship for J. Gamper
issued by the Leopold-Franzens-University of Innsbruck (Vicerector Prof. Dr Ulrike
Tanzer) are gratefully acknowledged. The computational results presented have been
achieved (in part) using the HPC infrastructure of the University of Innsbruck.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Jakob
full_name: Gamper, Jakob
last_name: Gamper
- first_name: Florian
full_name: Kluibenschedl, Florian
id: 7499e70e-eb2c-11ec-b98b-f925648bc9d9
last_name: Kluibenschedl
- first_name: Alexander K.H.
full_name: Weiss, Alexander K.H.
last_name: Weiss
- first_name: Thomas S.
full_name: Hofer, Thomas S.
last_name: Hofer
citation:
ama: Gamper J, Kluibenschedl F, Weiss AKH, Hofer TS. Accessing position space wave
functions in band structure calculations of periodic systems - a generalized,
adapted numerov implementation for one-, two-, and three-dimensional quantum problems.
Journal of Physical Chemistry Letters. 2023;14(33):7395-7403. doi:10.1021/acs.jpclett.3c01707
apa: Gamper, J., Kluibenschedl, F., Weiss, A. K. H., & Hofer, T. S. (2023).
Accessing position space wave functions in band structure calculations of periodic
systems - a generalized, adapted numerov implementation for one-, two-, and three-dimensional
quantum problems. Journal of Physical Chemistry Letters. American Chemical
Society. https://doi.org/10.1021/acs.jpclett.3c01707
chicago: Gamper, Jakob, Florian Kluibenschedl, Alexander K.H. Weiss, and Thomas
S. Hofer. “Accessing Position Space Wave Functions in Band Structure Calculations
of Periodic Systems - a Generalized, Adapted Numerov Implementation for One-,
Two-, and Three-Dimensional Quantum Problems.” Journal of Physical Chemistry
Letters. American Chemical Society, 2023. https://doi.org/10.1021/acs.jpclett.3c01707.
ieee: J. Gamper, F. Kluibenschedl, A. K. H. Weiss, and T. S. Hofer, “Accessing position
space wave functions in band structure calculations of periodic systems - a generalized,
adapted numerov implementation for one-, two-, and three-dimensional quantum problems,”
Journal of Physical Chemistry Letters, vol. 14, no. 33. American Chemical
Society, pp. 7395–7403, 2023.
ista: Gamper J, Kluibenschedl F, Weiss AKH, Hofer TS. 2023. Accessing position space
wave functions in band structure calculations of periodic systems - a generalized,
adapted numerov implementation for one-, two-, and three-dimensional quantum problems.
Journal of Physical Chemistry Letters. 14(33), 7395–7403.
mla: Gamper, Jakob, et al. “Accessing Position Space Wave Functions in Band Structure
Calculations of Periodic Systems - a Generalized, Adapted Numerov Implementation
for One-, Two-, and Three-Dimensional Quantum Problems.” Journal of Physical
Chemistry Letters, vol. 14, no. 33, American Chemical Society, 2023, pp. 7395–403,
doi:10.1021/acs.jpclett.3c01707.
short: J. Gamper, F. Kluibenschedl, A.K.H. Weiss, T.S. Hofer, Journal of Physical
Chemistry Letters 14 (2023) 7395–7403.
date_created: 2023-09-03T22:01:16Z
date_published: 2023-08-11T00:00:00Z
date_updated: 2023-09-06T11:04:31Z
day: '11'
ddc:
- '530'
- '540'
department:
- _id: GradSch
doi: 10.1021/acs.jpclett.3c01707
external_id:
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pmid:
- '37566743'
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intvolume: ' 14'
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month: '08'
oa: 1
oa_version: Published Version
page: 7395-7403
pmid: 1
publication: Journal of Physical Chemistry Letters
publication_identifier:
eissn:
- 1948-7185
publication_status: published
publisher: American Chemical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Accessing position space wave functions in band structure calculations of periodic
systems - a generalized, adapted numerov implementation for one-, two-, and three-dimensional
quantum problems
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 14
year: '2023'
...
---
_id: '12732'
abstract:
- lang: eng
text: "Nonergodic systems, whose out-of-equilibrium dynamics fail to thermalize,
provide a fascinating research direction both for fundamental reasons and for
application in state of the art quantum devices.\r\nGoing beyond the description
of statistical mechanics, ergodicity breaking yields a new paradigm in quantum
many-body physics, introducing novel phases of matter with no counterpart at equilibrium.\r\nIn
this Thesis, we address different open questions in the field, focusing on disorder-induced
many-body localization (MBL) and on weak ergodicity breaking in kinetically constrained
models.\r\nIn particular, we contribute to the debate about transport in kinetically
constrained models, studying the effect of $U(1)$ conservation and inversion-symmetry
breaking in a family of quantum East models.\r\nUsing tensor network techniques,
we analyze the dynamics of large MBL systems beyond the limit of exact numerical
methods.\r\nIn this setting, we approach the debated topic of the coexistence
of localized and thermal eigenstates separated by energy thresholds known as many-body
mobility edges.\r\nInspired by recent experiments, our work further investigates
the localization of a small bath induced by the coupling to a large localized
chain, the so-called MBL proximity effect.\r\n\r\nIn the first Chapter, we introduce
a family of particle-conserving kinetically constrained models, inspired by the
quantum East model.\r\nThe system we study features strong inversion-symmetry
breaking, due to the nature of the correlated hopping.\r\nWe show that these models
host so-called quantum Hilbert space fragmentation, consisting of disconnected
subsectors in an entangled basis, and further provide an analytical description
of this phenomenon.\r\nWe further probe its effect on dynamics of simple product
states, showing revivals in fidelity and local observalbes.\r\nThe study of dynamics
within the largest subsector reveals an anomalous transient superdiffusive behavior
crossing over to slow logarithmic dynamics at later times.\r\nThis work suggests
that particle conserving constrained models with inversion-symmetry breaking realize
new universality classes of dynamics and invite their further theoretical and
experimental studies.\r\n\r\nNext, we use kinetic constraints and disorder to
design a model with many-body mobility edges in particle density.\r\nThis feature
allows to study the dynamics of localized and thermal states in large systems
beyond the limitations of previous studies.\r\nThe time-evolution shows typical
signatures of localization at small densities, replaced by thermal behavior at
larger densities.\r\nOur results provide evidence in favor of the stability of
many-body mobility edges, which was recently challenged by a theoretical argument.\r\nTo
support our findings, we probe the mechanism proposed as a cause of delocalization
in many-body localized systems with mobility edges suggesting its ineffectiveness
in the model studied.\r\n\r\nIn the last Chapter of this Thesis, we address the
topic of many-body localization proximity effect.\r\nWe study a model inspired
by recent experiments, featuring Anderson localized coupled to a small bath of
free hard-core bosons.\r\nThe interaction among the two particle species results
in non-trivial dynamics, which we probe using tensor network techniques.\r\nOur
simulations show convincing evidence of many-body localization proximity effect
when the bath is composed by a single free particle and interactions are strong.\r\nWe
furthter observe an anomalous entanglement dynamics, which we explain through
a phenomenological theory.\r\nFinally, we extract highly excited eigenstates of
large systems, providing supplementary evidence in favor of our findings."
acknowledged_ssus:
- _id: ScienComp
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Pietro
full_name: Brighi, Pietro
id: 4115AF5C-F248-11E8-B48F-1D18A9856A87
last_name: Brighi
orcid: 0000-0002-7969-2729
citation:
ama: Brighi P. Ergodicity breaking in disordered and kinetically constrained quantum
many-body systems. 2023. doi:10.15479/at:ista:12732
apa: Brighi, P. (2023). Ergodicity breaking in disordered and kinetically constrained
quantum many-body systems. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12732
chicago: Brighi, Pietro. “Ergodicity Breaking in Disordered and Kinetically Constrained
Quantum Many-Body Systems.” Institute of Science and Technology Austria, 2023.
https://doi.org/10.15479/at:ista:12732.
ieee: P. Brighi, “Ergodicity breaking in disordered and kinetically constrained
quantum many-body systems,” Institute of Science and Technology Austria, 2023.
ista: Brighi P. 2023. Ergodicity breaking in disordered and kinetically constrained
quantum many-body systems. Institute of Science and Technology Austria.
mla: Brighi, Pietro. Ergodicity Breaking in Disordered and Kinetically Constrained
Quantum Many-Body Systems. Institute of Science and Technology Austria, 2023,
doi:10.15479/at:ista:12732.
short: P. Brighi, Ergodicity Breaking in Disordered and Kinetically Constrained
Quantum Many-Body Systems, Institute of Science and Technology Austria, 2023.
date_created: 2023-03-17T13:30:48Z
date_published: 2023-03-21T00:00:00Z
date_updated: 2023-09-20T10:44:12Z
day: '21'
ddc:
- '530'
degree_awarded: PhD
department:
- _id: GradSch
- _id: MaSe
doi: 10.15479/at:ista:12732
ec_funded: 1
file:
- access_level: closed
checksum: 5d2de651ef9449c1b8dc27148ca74777
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creator: pbrighi
date_created: 2023-03-23T16:42:56Z
date_updated: 2023-03-23T16:42:56Z
file_id: '12753'
file_name: Thesis_sub_PBrighi.zip
file_size: 42167561
relation: source_file
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checksum: 7caa153d4a5b0873a79358787d2dfe1e
content_type: application/pdf
creator: pbrighi
date_created: 2023-03-23T16:43:14Z
date_updated: 2023-03-23T16:43:14Z
file_id: '12754'
file_name: Thesis_PBrighi.pdf
file_size: 13977000
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file_date_updated: 2023-03-23T16:43:14Z
has_accepted_license: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: None
page: '158'
project:
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '850899'
name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '11470'
relation: part_of_dissertation
status: public
- id: '8308'
relation: part_of_dissertation
status: public
- id: '11469'
relation: part_of_dissertation
status: public
- id: '12750'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
title: Ergodicity breaking in disordered and kinetically constrained quantum many-body
systems
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '13120'
abstract:
- lang: eng
text: 'We formalized general (i.e., type-0) grammars using the Lean 3 proof assistant.
We defined basic notions of rewrite rules and of words derived by a grammar, and
used grammars to show closure of the class of type-0 languages under four operations:
union, reversal, concatenation, and the Kleene star. The literature mostly focuses
on Turing machine arguments, which are possibly more difficult to formalize. For
the Kleene star, we could not follow the literature and came up with our own grammar-based
construction.'
acknowledgement: "Jasmin Blanchette: This research has received funding from the Netherlands
Organization\r\nfor Scientific Research (NWO) under the Vidi program (project No.
016.Vidi.189.037, Lean Forward).\r\n__\r\nWe thank Vladimir Kolmogorov for making
this collaboration possible. We\r\nthank Václav Končický for discussing ideas about
the Kleene star construction. We thank Patrick Johnson, Floris van Doorn, and Damiano
Testa for their small yet very valuable contributions to our code. We thank Eric
Wieser for simplifying one of our proofs. We thank Mark Summerfield for suggesting
textual improvements. We thank the anonymous reviewers for very helpful comments.
Finally, we thank the Lean community for helping us with various technical issues
and answering many questions. "
alternative_title:
- LIPIcs
article_number: '15'
article_processing_charge: No
author:
- first_name: Martin
full_name: Dvorak, Martin
id: 40ED02A8-C8B4-11E9-A9C0-453BE6697425
last_name: Dvorak
orcid: 0000-0001-5293-214X
- first_name: Jasmin
full_name: Blanchette, Jasmin
last_name: Blanchette
citation:
ama: 'Dvorak M, Blanchette J. Closure properties of general grammars - formally
verified. In: 14th International Conference on Interactive Theorem Proving.
Vol 268. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2023. doi:10.4230/LIPIcs.ITP.2023.15'
apa: 'Dvorak, M., & Blanchette, J. (2023). Closure properties of general grammars
- formally verified. In 14th International Conference on Interactive Theorem
Proving (Vol. 268). Bialystok, Poland: Schloss Dagstuhl - Leibniz-Zentrum
für Informatik. https://doi.org/10.4230/LIPIcs.ITP.2023.15'
chicago: Dvorak, Martin, and Jasmin Blanchette. “Closure Properties of General Grammars
- Formally Verified.” In 14th International Conference on Interactive Theorem
Proving, Vol. 268. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2023.
https://doi.org/10.4230/LIPIcs.ITP.2023.15.
ieee: M. Dvorak and J. Blanchette, “Closure properties of general grammars - formally
verified,” in 14th International Conference on Interactive Theorem Proving,
Bialystok, Poland, 2023, vol. 268.
ista: 'Dvorak M, Blanchette J. 2023. Closure properties of general grammars - formally
verified. 14th International Conference on Interactive Theorem Proving. ITP: International
Conference on Interactive Theorem Proving, LIPIcs, vol. 268, 15.'
mla: Dvorak, Martin, and Jasmin Blanchette. “Closure Properties of General Grammars
- Formally Verified.” 14th International Conference on Interactive Theorem
Proving, vol. 268, 15, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2023, doi:10.4230/LIPIcs.ITP.2023.15.
short: M. Dvorak, J. Blanchette, in:, 14th International Conference on Interactive
Theorem Proving, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2023.
conference:
end_date: 2023-08-04
location: Bialystok, Poland
name: 'ITP: International Conference on Interactive Theorem Proving'
start_date: 2023-07-31
date_created: 2023-06-05T07:29:05Z
date_published: 2023-07-27T00:00:00Z
date_updated: 2023-09-25T11:04:29Z
day: '27'
ddc:
- '000'
department:
- _id: GradSch
- _id: VlKo
doi: 10.4230/LIPIcs.ITP.2023.15
external_id:
arxiv:
- '2302.06420'
file:
- access_level: open_access
checksum: 773a0197f05b67feaa6cb1e17ec3642d
content_type: application/pdf
creator: dernst
date_created: 2023-08-07T11:55:43Z
date_updated: 2023-08-07T11:55:43Z
file_id: '13982'
file_name: 2023_LIPIcS_Dvorak.pdf
file_size: 715976
relation: main_file
success: 1
file_date_updated: 2023-08-07T11:55:43Z
has_accepted_license: '1'
intvolume: ' 268'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: 14th International Conference on Interactive Theorem Proving
publication_identifier:
eissn:
- 1868-8969
isbn:
- '9783959772846'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/madvorak/grammars/tree/publish
scopus_import: '1'
status: public
title: Closure properties of general grammars - formally verified
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 268
year: '2023'
...
---
_id: '13081'
abstract:
- lang: eng
text: During development, tissues undergo changes in size and shape to form functional
organs. Distinct cellular processes such as cell division and cell rearrangements
underlie tissue morphogenesis. Yet how the distinct processes are controlled and
coordinated, and how they contribute to morphogenesis is poorly understood. In
our study, we addressed these questions using the developing mouse neural tube.
This epithelial organ transforms from a flat epithelial sheet to an epithelial
tube while increasing in size and undergoing morpho-gen-mediated patterning. The
extent and mechanism of neural progenitor rearrangement within the developing
mouse neuroepithelium is unknown. To investigate this, we per-formed high resolution
lineage tracing analysis to quantify the extent of epithelial rear-rangement at
different stages of neural tube development. We quantitatively described the relationship
between apical cell size with cell cycle dependent interkinetic nuclear migra-tions
(IKNM) and performed high cellular resolution live imaging of the neuroepithelium
to study the dynamics of junctional remodeling. Furthermore, developed a vertex
model of the neuroepithelium to investigate the quantitative contribution of cell
proliferation, cell differentiation and mechanical properties to the epithelial
rearrangement dynamics and validated the model predictions through functional
experiments. Our analysis revealed that at early developmental stages, the apical
cell area kinetics driven by IKNM induce high lev-els of cell rearrangements in
a regime of high junctional tension and contractility. After E9.5, there is a
sharp decline in the extent of cell rearrangements, suggesting that the epi-thelium
transitions from a fluid-like to a solid-like state. We found that this transition
is regulated by the growth rate of the tissue, rather than by changes in cell-cell
adhesion and contractile forces. Overall, our study provides a quantitative description
of the relationship between tissue growth, cell cycle dynamics, epithelia rearrangements
and the emergent tissue material properties, and novel insights on how epithelial
cell dynamics influences tissue morphogenesis.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Laura
full_name: Bocanegra, Laura
id: 4896F754-F248-11E8-B48F-1D18A9856A87
last_name: Bocanegra
citation:
ama: Bocanegra L. Epithelial dynamics during mouse neural tube development. 2023.
doi:10.15479/at:ista:13081
apa: Bocanegra, L. (2023). Epithelial dynamics during mouse neural tube development.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:13081
chicago: Bocanegra, Laura. “Epithelial Dynamics during Mouse Neural Tube Development.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:13081.
ieee: L. Bocanegra, “Epithelial dynamics during mouse neural tube development,”
Institute of Science and Technology Austria, 2023.
ista: Bocanegra L. 2023. Epithelial dynamics during mouse neural tube development.
Institute of Science and Technology Austria.
mla: Bocanegra, Laura. Epithelial Dynamics during Mouse Neural Tube Development.
Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:13081.
short: L. Bocanegra, Epithelial Dynamics during Mouse Neural Tube Development, Institute
of Science and Technology Austria, 2023.
date_created: 2023-05-23T19:10:42Z
date_published: 2023-05-23T00:00:00Z
date_updated: 2023-10-04T11:14:04Z
day: '23'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: AnKi
doi: 10.15479/at:ista:13081
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date_created: 2023-05-25T06:32:12Z
date_updated: 2023-05-25T06:32:12Z
file_id: '13089'
file_name: Thesis_final_LauraBocanegra.docx
file_size: 25615534
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date_created: 2023-05-25T06:32:16Z
date_updated: 2023-05-25T06:32:16Z
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file_name: TotalFinal_Thesis_LauraBocanegraArx.pdf
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file_date_updated: 2023-05-25T06:32:16Z
has_accepted_license: '1'
language:
- iso: eng
month: '05'
oa_version: Published Version
page: '93'
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '9349'
relation: part_of_dissertation
status: public
- id: '12837'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
title: Epithelial dynamics during mouse neural tube development
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12349'
abstract:
- lang: eng
text: Statistics of natural scenes are not uniform - their structure varies dramatically
from ground to sky. It remains unknown whether these non-uniformities are reflected
in the large-scale organization of the early visual system and what benefits such
adaptations would confer. Here, by relying on the efficient coding hypothesis,
we predict that changes in the structure of receptive fields across visual space
increase the efficiency of sensory coding. We show experimentally that, in agreement
with our predictions, receptive fields of retinal ganglion cells change their
shape along the dorsoventral retinal axis, with a marked surround asymmetry at
the visual horizon. Our work demonstrates that, according to principles of efficient
coding, the panoramic structure of natural scenes is exploited by the retina across
space and cell-types.
acknowledged_ssus:
- _id: ScienComp
- _id: PreCl
- _id: LifeSc
- _id: Bio
acknowledgement: We thank Hiroki Asari for sharing the dataset of naturalistic images,
Anton Sumser for sharing visual stimulus code, Yoav Ben Simon for initial explorative
work with the generation of AAVs, and Tomas Vega-Zuñiga for help with immunostainings.
We also thank Gasper Tkacik and members of the Neuroethology group for their comments
on the manuscript. This research was supported by the Scientific Service Units of
IST Austria through resources provided by Scientific Computing, the Preclinical
Facility, the Lab Support Facility, and the Imaging and Optics Facility. This work
was supported by European Union Horizon 2020 Marie Skłodowska-Curie grant 665385
(DG), Austrian Science Fund (FWF) stand-alone grant P 34015 (WM), Human Frontiers
Science Program LT000256/2018-L (AS), EMBO ALTF 1098-2017 (AS) and the European
Research Council Starting Grant 756502 (MJ).
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last_name: Sumser
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last_name: Symonova
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full_name: Svaton, Jan
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citation:
ama: Gupta D, Mlynarski WF, Sumser AL, Symonova O, Svaton J, Jösch MA. Panoramic
visual statistics shape retina-wide organization of receptive fields. Nature
Neuroscience. 2023;26:606-614. doi:10.1038/s41593-023-01280-0
apa: Gupta, D., Mlynarski, W. F., Sumser, A. L., Symonova, O., Svaton, J., &
Jösch, M. A. (2023). Panoramic visual statistics shape retina-wide organization
of receptive fields. Nature Neuroscience. Springer Nature. https://doi.org/10.1038/s41593-023-01280-0
chicago: Gupta, Divyansh, Wiktor F Mlynarski, Anton L Sumser, Olga Symonova, Jan
Svaton, and Maximilian A Jösch. “Panoramic Visual Statistics Shape Retina-Wide
Organization of Receptive Fields.” Nature Neuroscience. Springer Nature,
2023. https://doi.org/10.1038/s41593-023-01280-0.
ieee: D. Gupta, W. F. Mlynarski, A. L. Sumser, O. Symonova, J. Svaton, and M. A.
Jösch, “Panoramic visual statistics shape retina-wide organization of receptive
fields,” Nature Neuroscience, vol. 26. Springer Nature, pp. 606–614, 2023.
ista: Gupta D, Mlynarski WF, Sumser AL, Symonova O, Svaton J, Jösch MA. 2023. Panoramic
visual statistics shape retina-wide organization of receptive fields. Nature Neuroscience.
26, 606–614.
mla: Gupta, Divyansh, et al. “Panoramic Visual Statistics Shape Retina-Wide Organization
of Receptive Fields.” Nature Neuroscience, vol. 26, Springer Nature, 2023,
pp. 606–14, doi:10.1038/s41593-023-01280-0.
short: D. Gupta, W.F. Mlynarski, A.L. Sumser, O. Symonova, J. Svaton, M.A. Jösch,
Nature Neuroscience 26 (2023) 606–614.
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title: Panoramic visual statistics shape retina-wide organization of receptive fields
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legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
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...
---
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abstract:
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text: 'Statistics of natural scenes are not uniform - their structure varies dramatically
from ground to sky. It remains unknown whether these non-uniformities are reflected
in the large-scale organization of the early visual system and what benefits such
adaptations would confer. Here, by relying on the efficient coding hypothesis,
we predict that changes in the structure of receptive fields across visual space
increase the efficiency of sensory coding. We show experimentally that, in agreement
with our predictions, receptive fields of retinal ganglion cells change their
shape along the dorsoventral retinal axis, with a marked surround asymmetry at
the visual horizon. Our work demonstrates that, according to principles of efficient
coding, the panoramic structure of natural scenes is exploited by the retina across
space and cell-types. '
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shape retina-wide organization of receptive fields. 2023. doi:10.15479/AT:ISTA:12370'
apa: 'Gupta, D., Sumser, A. L., & Jösch, M. A. (2023). Research Data for: Panoramic
visual statistics shape retina-wide organization of receptive fields. Institute
of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:12370'
chicago: 'Gupta, Divyansh, Anton L Sumser, and Maximilian A Jösch. “Research Data
for: Panoramic Visual Statistics Shape Retina-Wide Organization of Receptive Fields.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/AT:ISTA:12370.'
ieee: 'D. Gupta, A. L. Sumser, and M. A. Jösch, “Research Data for: Panoramic visual
statistics shape retina-wide organization of receptive fields.” Institute of Science
and Technology Austria, 2023.'
ista: 'Gupta D, Sumser AL, Jösch MA. 2023. Research Data for: Panoramic visual statistics
shape retina-wide organization of receptive fields, Institute of Science and Technology
Austria, 10.15479/AT:ISTA:12370.'
mla: 'Gupta, Divyansh, et al. Research Data for: Panoramic Visual Statistics
Shape Retina-Wide Organization of Receptive Fields. Institute of Science and
Technology Austria, 2023, doi:10.15479/AT:ISTA:12370.'
short: D. Gupta, A.L. Sumser, M.A. Jösch, (2023).
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text: "The extension of extremal combinatorics to the setting of exterior algebra
is a work\r\nin progress that gained attention recently. In this thesis, we study
the combinatorial structure of exterior algebra by introducing a dictionary that
translates the notions from the set systems into the framework of exterior algebra.
We show both generalizations of celebrated Erdös--Ko--Rado theorem and Hilton--Milner
theorem to the setting of exterior algebra in the simplest non-trivial case of
two-forms.\r\n"
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and Technology Austria. https://doi.org/10.15479/at:ista:13331
chicago: Köse, Seyda. “Exterior Algebra and Combinatorics.” Institute of Science
and Technology Austria, 2023. https://doi.org/10.15479/at:ista:13331.
ieee: S. Köse, “Exterior algebra and combinatorics,” Institute of Science and Technology
Austria, 2023.
ista: Köse S. 2023. Exterior algebra and combinatorics. Institute of Science and
Technology Austria.
mla: Köse, Seyda. Exterior Algebra and Combinatorics. Institute of Science
and Technology Austria, 2023, doi:10.15479/at:ista:13331.
short: S. Köse, Exterior Algebra and Combinatorics, Institute of Science and Technology
Austria, 2023.
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---
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abstract:
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text: The celebrated Erdős–Ko–Rado theorem about the maximal size of an intersecting
family of r-element subsets of was extended to the setting of exterior algebra
in [5, Theorem 2.3] and in [6, Theorem 1.4]. However, the equality case has not
been settled yet. In this short note, we show that the extension of the Erdős–Ko–Rado
theorem and the characterization of the equality case therein, as well as those
of the Hilton–Milner theorem to the setting of exterior algebra in the simplest
non-trivial case of two-forms follow from a folklore puzzle about possible arrangements
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author:
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full_name: Ivanov, Grigory
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last_name: Ivanov
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last_name: Köse
citation:
ama: Ivanov G, Köse S. Erdős-Ko-Rado and Hilton-Milner theorems for two-forms. Discrete
Mathematics. 2023;346(6). doi:10.1016/j.disc.2023.113363
apa: Ivanov, G., & Köse, S. (2023). Erdős-Ko-Rado and Hilton-Milner theorems
for two-forms. Discrete Mathematics. Elsevier. https://doi.org/10.1016/j.disc.2023.113363
chicago: Ivanov, Grigory, and Seyda Köse. “Erdős-Ko-Rado and Hilton-Milner Theorems
for Two-Forms.” Discrete Mathematics. Elsevier, 2023. https://doi.org/10.1016/j.disc.2023.113363.
ieee: G. Ivanov and S. Köse, “Erdős-Ko-Rado and Hilton-Milner theorems for two-forms,”
Discrete Mathematics, vol. 346, no. 6. Elsevier, 2023.
ista: Ivanov G, Köse S. 2023. Erdős-Ko-Rado and Hilton-Milner theorems for two-forms.
Discrete Mathematics. 346(6), 113363.
mla: Ivanov, Grigory, and Seyda Köse. “Erdős-Ko-Rado and Hilton-Milner Theorems
for Two-Forms.” Discrete Mathematics, vol. 346, no. 6, 113363, Elsevier,
2023, doi:10.1016/j.disc.2023.113363.
short: G. Ivanov, S. Köse, Discrete Mathematics 346 (2023).
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date_updated: 2023-10-04T11:54:57Z
day: '01'
department:
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doi: 10.1016/j.disc.2023.113363
external_id:
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main_file_link:
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url: ' https://doi.org/10.48550/arXiv.2201.10892'
month: '06'
oa: 1
oa_version: Preprint
publication: Discrete Mathematics
publication_identifier:
issn:
- 0012-365X
publication_status: published
publisher: Elsevier
quality_controlled: '1'
related_material:
record:
- id: '13331'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Erdős-Ko-Rado and Hilton-Milner theorems for two-forms
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 346
year: '2023'
...
---
_id: '13221'
abstract:
- lang: eng
text: The safety-liveness dichotomy is a fundamental concept in formal languages
which plays a key role in verification. Recently, this dichotomy has been lifted
to quantitative properties, which are arbitrary functions from infinite words
to partially-ordered domains. We look into harnessing the dichotomy for the specific
classes of quantitative properties expressed by quantitative automata. These automata
contain finitely many states and rational-valued transition weights, and their
common value functions Inf, Sup, LimInf, LimSup, LimInfAvg, LimSupAvg, and DSum
map infinite words into the totallyordered domain of real numbers. In this automata-theoretic
setting, we establish a connection between quantitative safety and topological
continuity and provide an alternative characterization of quantitative safety
and liveness in terms of their boolean counterparts. For all common value functions,
we show how the safety closure of a quantitative automaton can be constructed
in PTime, and we provide PSpace-complete checks of whether a given quantitative
automaton is safe or live, with the exception of LimInfAvg and LimSupAvg automata,
for which the safety check is in ExpSpace. Moreover, for deterministic Sup, LimInf,
and LimSup automata, we give PTime decompositions into safe and live automata.
These decompositions enable the separation of techniques for safety and liveness
verification for quantitative specifications.
acknowledgement: We thank Christof Löding for pointing us to some results on PSpace-hardess
of universality problems and the anonymous reviewers for their helpful comments.
This work was supported in part by the ERC-2020-AdG 101020093 and the Israel Science
Foundation grant 2410/22.
alternative_title:
- LIPIcs
article_number: '17'
article_processing_charge: No
author:
- first_name: Udi
full_name: Boker, Udi
id: 31E297B6-F248-11E8-B48F-1D18A9856A87
last_name: Boker
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000-0002-2985-7724
- first_name: Nicolas Adrien
full_name: Mazzocchi, Nicolas Adrien
id: b26baa86-3308-11ec-87b0-8990f34baa85
last_name: Mazzocchi
- first_name: Naci E
full_name: Sarac, Naci E
id: 8C6B42F8-C8E6-11E9-A03A-F2DCE5697425
last_name: Sarac
citation:
ama: 'Boker U, Henzinger TA, Mazzocchi NA, Sarac NE. Safety and liveness of quantitative
automata. In: 34th International Conference on Concurrency Theory. Vol
279. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2023. doi:10.4230/LIPIcs.CONCUR.2023.17'
apa: 'Boker, U., Henzinger, T. A., Mazzocchi, N. A., & Sarac, N. E. (2023).
Safety and liveness of quantitative automata. In 34th International Conference
on Concurrency Theory (Vol. 279). Antwerp, Belgium: Schloss Dagstuhl - Leibniz-Zentrum
für Informatik. https://doi.org/10.4230/LIPIcs.CONCUR.2023.17'
chicago: Boker, Udi, Thomas A Henzinger, Nicolas Adrien Mazzocchi, and Naci E Sarac.
“Safety and Liveness of Quantitative Automata.” In 34th International Conference
on Concurrency Theory, Vol. 279. Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2023. https://doi.org/10.4230/LIPIcs.CONCUR.2023.17.
ieee: U. Boker, T. A. Henzinger, N. A. Mazzocchi, and N. E. Sarac, “Safety and liveness
of quantitative automata,” in 34th International Conference on Concurrency
Theory, Antwerp, Belgium, 2023, vol. 279.
ista: 'Boker U, Henzinger TA, Mazzocchi NA, Sarac NE. 2023. Safety and liveness
of quantitative automata. 34th International Conference on Concurrency Theory.
CONCUR: Conference on Concurrency Theory, LIPIcs, vol. 279, 17.'
mla: Boker, Udi, et al. “Safety and Liveness of Quantitative Automata.” 34th
International Conference on Concurrency Theory, vol. 279, 17, Schloss Dagstuhl
- Leibniz-Zentrum für Informatik, 2023, doi:10.4230/LIPIcs.CONCUR.2023.17.
short: U. Boker, T.A. Henzinger, N.A. Mazzocchi, N.E. Sarac, in:, 34th International
Conference on Concurrency Theory, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2023.
conference:
end_date: 2023-09-23
location: Antwerp, Belgium
name: 'CONCUR: Conference on Concurrency Theory'
start_date: 2023-09-18
date_created: 2023-07-14T10:00:15Z
date_published: 2023-09-01T00:00:00Z
date_updated: 2023-10-09T07:14:03Z
day: '01'
ddc:
- '000'
department:
- _id: GradSch
- _id: ToHe
doi: 10.4230/LIPIcs.CONCUR.2023.17
ec_funded: 1
external_id:
arxiv:
- '2307.06016'
file:
- access_level: open_access
checksum: d40e57a04448ea5c77d7e1cfb9590a81
content_type: application/pdf
creator: esarac
date_created: 2023-07-14T12:03:48Z
date_updated: 2023-07-14T12:03:48Z
file_id: '13224'
file_name: CONCUR23.pdf
file_size: 755529
relation: main_file
success: 1
file_date_updated: 2023-07-14T12:03:48Z
has_accepted_license: '1'
intvolume: ' 279'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
project:
- _id: 62781420-2b32-11ec-9570-8d9b63373d4d
call_identifier: H2020
grant_number: '101020093'
name: Vigilant Algorithmic Monitoring of Software
publication: 34th International Conference on Concurrency Theory
publication_identifier:
eissn:
- 1868-8969
isbn:
- '9783959772990'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
status: public
title: Safety and liveness of quantitative automata
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 279
year: '2023'
...
---
_id: '12406'
abstract:
- lang: eng
text: Let X be a sufficiently large positive integer. We prove that one may choose
a subset S of primes with cardinality O(logX) such that a positive proportion
of integers less than X can be represented by x2+py2 for at least one p∈S.
acknowledgement: "This article is a version the author’s master thesis at the University
of Bonn. The author would like to thank his advisor Valentin Blomer for introducing
the problem, and giving generous feedback and encouragement along the way, especially
during the global pandemic.\r\nThe author thanks Edgar Assing for his lectures on
analytic number theory. Finally, the author is grateful to the anonymous referees
for their valuable time and comments.\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Yijie
full_name: Diao, Yijie
id: 7b7eb4ca-eb2c-11ec-b98b-accec0b20c3b
last_name: Diao
orcid: 0000-0002-4989-5330
citation:
ama: Diao Y. Density of the union of positive diagonal binary quadratic forms. Acta
Arithmetica. 2023;207:1-17. doi:10.4064/aa210830-24-11
apa: Diao, Y. (2023). Density of the union of positive diagonal binary quadratic
forms. Acta Arithmetica. Instytut Matematyczny. https://doi.org/10.4064/aa210830-24-11
chicago: Diao, Yijie. “Density of the Union of Positive Diagonal Binary Quadratic
Forms.” Acta Arithmetica. Instytut Matematyczny, 2023. https://doi.org/10.4064/aa210830-24-11.
ieee: Y. Diao, “Density of the union of positive diagonal binary quadratic forms,”
Acta Arithmetica, vol. 207. Instytut Matematyczny, pp. 1–17, 2023.
ista: Diao Y. 2023. Density of the union of positive diagonal binary quadratic forms.
Acta Arithmetica. 207, 1–17.
mla: Diao, Yijie. “Density of the Union of Positive Diagonal Binary Quadratic Forms.”
Acta Arithmetica, vol. 207, Instytut Matematyczny, 2023, pp. 1–17, doi:10.4064/aa210830-24-11.
short: Y. Diao, Acta Arithmetica 207 (2023) 1–17.
date_created: 2023-01-26T21:17:04Z
date_published: 2023-01-09T00:00:00Z
date_updated: 2023-10-17T09:15:17Z
day: '09'
department:
- _id: GradSch
doi: 10.4064/aa210830-24-11
external_id:
arxiv:
- '2103.08268'
isi:
- '000912903000001'
intvolume: ' 207'
isi: 1
keyword:
- Algebra
- Number Theory
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2103.08268
month: '01'
oa: 1
oa_version: Preprint
page: 1-17
publication: Acta Arithmetica
publication_identifier:
eissn:
- 1730-6264
issn:
- 0065-1036
publication_status: published
publisher: Instytut Matematyczny
quality_controlled: '1'
status: public
title: Density of the union of positive diagonal binary quadratic forms
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 207
year: '2023'
...
---
_id: '14422'
abstract:
- lang: eng
text: "Animals exhibit a remarkable ability to learn and remember new behaviors,
skills, and associations throughout their lifetime. These capabilities are made
possible thanks to a variety of\r\nchanges in the brain throughout adulthood,
regrouped under the term \"plasticity\". Some cells\r\nin the brain —neurons—
and specifically changes in the connections between neurons, the\r\nsynapses,
were shown to be crucial for the formation, selection, and consolidation of memories\r\nfrom
past experiences. These ongoing changes of synapses across time are called synaptic\r\nplasticity.
Understanding how a myriad of biochemical processes operating at individual\r\nsynapses
can somehow work in concert to give rise to meaningful changes in behavior is
a\r\nfascinating problem and an active area of research.\r\nHowever, the experimental
search for the precise plasticity mechanisms at play in the brain\r\nis daunting,
as it is difficult to control and observe synapses during learning. Theoretical\r\napproaches
have thus been the default method to probe the plasticity-behavior connection.
Such\r\nstudies attempt to extract unifying principles across synapses and model
all observed synaptic\r\nchanges using plasticity rules: equations that govern
the evolution of synaptic strengths across\r\ntime in neuronal network models.
These rules can use many relevant quantities to determine\r\nthe magnitude of
synaptic changes, such as the precise timings of pre- and postsynaptic\r\naction
potentials, the recent neuronal activity levels, the state of neighboring synapses,
etc.\r\nHowever, analytical studies rely heavily on human intuition and are forced
to make simplifying\r\nassumptions about plasticity rules.\r\nIn this thesis,
we aim to assist and augment human intuition in this search for plasticity rules.\r\nWe
explore whether a numerical approach could automatically discover the plasticity
rules\r\nthat elicit desired behaviors in large networks of interconnected neurons.
This approach is\r\ndubbed meta-learning synaptic plasticity: learning plasticity
rules which themselves will make\r\nneuronal networks learn how to solve a desired
task. We first write all the potential plasticity\r\nmechanisms to consider using
a single expression with adjustable parameters. We then optimize\r\nthese plasticity
parameters using evolutionary strategies or Bayesian inference on tasks known\r\nto
involve synaptic plasticity, such as familiarity detection and network stabilization.\r\nWe
show that these automated approaches are powerful tools, able to complement established\r\nanalytical
methods. By comprehensively screening plasticity rules at all synapse types in\r\nrealistic,
spiking neuronal network models, we discover entire sets of degenerate plausible\r\nplasticity
rules that reliably elicit memory-related behaviors. Our approaches allow for
more\r\nrobust experimental predictions, by abstracting out the idiosyncrasies
of individual plasticity\r\nrules, and provide fresh insights on synaptic plasticity
in spiking network models.\r\n"
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Basile J
full_name: Confavreux, Basile J
id: C7610134-B532-11EA-BD9F-F5753DDC885E
last_name: Confavreux
citation:
ama: 'Confavreux BJ. Synapseek: Meta-learning synaptic plasticity rules. 2023. doi:10.15479/at:ista:14422'
apa: 'Confavreux, B. J. (2023). Synapseek: Meta-learning synaptic plasticity
rules. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14422'
chicago: 'Confavreux, Basile J. “Synapseek: Meta-Learning Synaptic Plasticity Rules.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:14422.'
ieee: 'B. J. Confavreux, “Synapseek: Meta-learning synaptic plasticity rules,” Institute
of Science and Technology Austria, 2023.'
ista: 'Confavreux BJ. 2023. Synapseek: Meta-learning synaptic plasticity rules.
Institute of Science and Technology Austria.'
mla: 'Confavreux, Basile J. Synapseek: Meta-Learning Synaptic Plasticity Rules.
Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:14422.'
short: 'B.J. Confavreux, Synapseek: Meta-Learning Synaptic Plasticity Rules, Institute
of Science and Technology Austria, 2023.'
date_created: 2023-10-12T14:13:25Z
date_published: 2023-10-12T00:00:00Z
date_updated: 2023-10-18T09:20:56Z
day: '12'
ddc:
- '610'
degree_awarded: PhD
department:
- _id: GradSch
- _id: TiVo
doi: 10.15479/at:ista:14422
ec_funded: 1
file:
- access_level: closed
checksum: 7f636555eae7803323df287672fd13ed
content_type: application/pdf
creator: cchlebak
date_created: 2023-10-12T14:53:50Z
date_updated: 2023-10-12T14:54:52Z
embargo: 2024-10-12
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file_name: Confavreux_Thesis_2A.pdf
file_size: 30599717
relation: main_file
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checksum: 725e85946db92290a4583a0de9779e1b
content_type: application/x-zip-compressed
creator: cchlebak
date_created: 2023-10-18T07:38:34Z
date_updated: 2023-10-18T07:56:08Z
file_id: '14440'
file_name: Confavreux Thesis.zip
file_size: 68406739
relation: source_file
file_date_updated: 2023-10-18T07:56:08Z
has_accepted_license: '1'
language:
- iso: eng
month: '10'
oa_version: Published Version
page: '148'
project:
- _id: 0aacfa84-070f-11eb-9043-d7eb2c709234
call_identifier: H2020
grant_number: '819603'
name: Learning the shape of synaptic plasticity rules for neuronal architectures
and function through machine learning.
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '9633'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Tim P
full_name: Vogels, Tim P
id: CB6FF8D2-008F-11EA-8E08-2637E6697425
last_name: Vogels
orcid: 0000-0003-3295-6181
title: 'Synapseek: Meta-learning synaptic plasticity rules'
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14374'
abstract:
- lang: eng
text: "Superconductivity has many important applications ranging from levitating
trains over qubits to MRI scanners. The phenomenon is successfully modeled by
Bardeen-Cooper-Schrieffer (BCS) theory. From a mathematical perspective, BCS theory
has been studied extensively for systems without boundary. However, little is
known in the presence of boundaries. With the help of numerical methods physicists
observed that the critical temperature may increase in the presence of a boundary.
The goal of this thesis is to understand the influence of boundaries on the critical
temperature in BCS theory and to give a first rigorous justification of these
observations. On the way, we also study two-body Schrödinger operators on domains
with boundaries and prove additional results for superconductors without boundary.\r\n\r\nBCS
theory is based on a non-linear functional, where the minimizer indicates whether
the system is superconducting or in the normal, non-superconducting state. By
considering the Hessian of the BCS functional at the normal state, one can analyze
whether the normal state is possibly a minimum of the BCS functional and estimate
the critical temperature. The Hessian turns out to be a linear operator resembling
a Schrödinger operator for two interacting particles, but with more complicated
kinetic energy. As a first step, we study the two-body Schrödinger operator in
the presence of boundaries.\r\nFor Neumann boundary conditions, we prove that
the addition of a boundary can create new eigenvalues, which correspond to the
two particles forming a bound state close to the boundary.\r\n\r\nSecond, we need
to understand superconductivity in the translation invariant setting. While in
three dimensions this has been extensively studied, there is no mathematical literature
for the one and two dimensional cases. In dimensions one and two, we compute the
weak coupling asymptotics of the critical temperature and the energy gap in the
translation invariant setting. We also prove that their ratio is independent of
the microscopic details of the model in the weak coupling limit; this property
is referred to as universality.\r\n\r\nIn the third part, we study the critical
temperature of superconductors in the presence of boundaries. We start by considering
the one-dimensional case of a half-line with contact interaction. Then, we generalize
the results to generic interactions and half-spaces in one, two and three dimensions.
Finally, we compare the critical temperature of a quarter space in two dimensions
to the critical temperatures of a half-space and of the full space."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Barbara
full_name: Roos, Barbara
id: 5DA90512-D80F-11E9-8994-2E2EE6697425
last_name: Roos
orcid: 0000-0002-9071-5880
citation:
ama: Roos B. Boundary superconductivity in BCS theory. 2023. doi:10.15479/at:ista:14374
apa: Roos, B. (2023). Boundary superconductivity in BCS theory. Institute
of Science and Technology Austria. https://doi.org/10.15479/at:ista:14374
chicago: Roos, Barbara. “Boundary Superconductivity in BCS Theory.” Institute of
Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:14374.
ieee: B. Roos, “Boundary superconductivity in BCS theory,” Institute of Science
and Technology Austria, 2023.
ista: Roos B. 2023. Boundary superconductivity in BCS theory. Institute of Science
and Technology Austria.
mla: Roos, Barbara. Boundary Superconductivity in BCS Theory. Institute of
Science and Technology Austria, 2023, doi:10.15479/at:ista:14374.
short: B. Roos, Boundary Superconductivity in BCS Theory, Institute of Science and
Technology Austria, 2023.
date_created: 2023-09-28T14:23:04Z
date_published: 2023-09-30T00:00:00Z
date_updated: 2023-10-27T10:37:30Z
day: '30'
ddc:
- '515'
- '539'
degree_awarded: PhD
department:
- _id: GradSch
- _id: RoSe
doi: 10.15479/at:ista:14374
ec_funded: 1
file:
- access_level: open_access
checksum: ef039ffc3de2cb8dee5b14110938e9b6
content_type: application/pdf
creator: broos
date_created: 2023-10-06T11:35:56Z
date_updated: 2023-10-06T11:35:56Z
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file_size: 2365702
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content_type: application/x-zip-compressed
creator: broos
date_created: 2023-10-06T11:38:01Z
date_updated: 2023-10-06T11:38:01Z
file_id: '14399'
file_name: Version5.zip
file_size: 4691734
relation: source_file
file_date_updated: 2023-10-06T11:38:01Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: '206'
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
- _id: bda63fe5-d553-11ed-ba76-a16e3d2f256b
grant_number: I06427
name: Mathematical Challenges in BCS Theory of Superconductivity
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '13207'
relation: part_of_dissertation
status: public
- id: '10850'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
title: Boundary superconductivity in BCS theory
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '13207'
abstract:
- lang: eng
text: We consider the linear BCS equation, determining the BCS critical temperature,
in the presence of a boundary, where Dirichlet boundary conditions are imposed.
In the one-dimensional case with point interactions, we prove that the critical
temperature is strictly larger than the bulk value, at least at weak coupling.
In particular, the Cooper-pair wave function localizes near the boundary, an effect
that cannot be modeled by effective Neumann boundary conditions on the order parameter
as often imposed in Ginzburg–Landau theory. We also show that the relative shift
in critical temperature vanishes if the coupling constant either goes to zero
or to infinity.
acknowledgement: We thank Egor Babaev for encouraging us to study this problem, and
Rupert Frank for many fruitful discussions. scussions. Funding. Funding from the
European Union’s Horizon 2020 research and innovation programme under the ERC grant
agreement No. 694227 (Barbara Roos and Robert Seiringer) is gratefully acknowledged.
article_processing_charge: No
article_type: original
author:
- first_name: Christian
full_name: Hainzl, Christian
last_name: Hainzl
- first_name: Barbara
full_name: Roos, Barbara
id: 5DA90512-D80F-11E9-8994-2E2EE6697425
last_name: Roos
orcid: 0000-0002-9071-5880
- first_name: Robert
full_name: Seiringer, Robert
id: 4AFD0470-F248-11E8-B48F-1D18A9856A87
last_name: Seiringer
orcid: 0000-0002-6781-0521
citation:
ama: Hainzl C, Roos B, Seiringer R. Boundary superconductivity in the BCS model.
Journal of Spectral Theory. 2023;12(4):1507–1540. doi:10.4171/JST/439
apa: Hainzl, C., Roos, B., & Seiringer, R. (2023). Boundary superconductivity
in the BCS model. Journal of Spectral Theory. EMS Press. https://doi.org/10.4171/JST/439
chicago: Hainzl, Christian, Barbara Roos, and Robert Seiringer. “Boundary Superconductivity
in the BCS Model.” Journal of Spectral Theory. EMS Press, 2023. https://doi.org/10.4171/JST/439.
ieee: C. Hainzl, B. Roos, and R. Seiringer, “Boundary superconductivity in the BCS
model,” Journal of Spectral Theory, vol. 12, no. 4. EMS Press, pp. 1507–1540,
2023.
ista: Hainzl C, Roos B, Seiringer R. 2023. Boundary superconductivity in the BCS
model. Journal of Spectral Theory. 12(4), 1507–1540.
mla: Hainzl, Christian, et al. “Boundary Superconductivity in the BCS Model.” Journal
of Spectral Theory, vol. 12, no. 4, EMS Press, 2023, pp. 1507–1540, doi:10.4171/JST/439.
short: C. Hainzl, B. Roos, R. Seiringer, Journal of Spectral Theory 12 (2023) 1507–1540.
date_created: 2023-07-10T16:35:45Z
date_published: 2023-05-18T00:00:00Z
date_updated: 2023-10-27T10:37:29Z
day: '18'
ddc:
- '530'
department:
- _id: GradSch
- _id: RoSe
doi: 10.4171/JST/439
ec_funded: 1
external_id:
arxiv:
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isi:
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intvolume: ' 12'
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language:
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month: '05'
oa: 1
oa_version: Published Version
page: 1507–1540
project:
- _id: 25C6DC12-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '694227'
name: Analysis of quantum many-body systems
publication: Journal of Spectral Theory
publication_identifier:
eissn:
- 1664-0403
issn:
- 1664-039X
publication_status: published
publisher: EMS Press
quality_controlled: '1'
related_material:
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- id: '14374'
relation: dissertation_contains
status: public
status: public
title: Boundary superconductivity in the BCS model
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 12
year: '2023'
...
---
_id: '14485'
abstract:
- lang: eng
text: "Batching is a technique that stores multiple keys/values in each node of
a data structure. In sequential search data structures, batching reduces latency
by reducing the number of cache misses and shortening the chain of pointers to
dereference. Applying batching to concurrent data structures is challenging, because
it is difficult to maintain the search property and keep contention low in the
presence of batching.\r\nIn this paper, we present a general methodology for leveraging
batching in concurrent search data structures, called BatchBoost. BatchBoost builds
a search data structure from distinct \"data\" and \"index\" layers. The data
layer’s purpose is to store a batch of key/value pairs in each of its nodes. The
index layer uses an unmodified concurrent search data structure to route operations
to a position in the data layer that is \"close\" to where the corresponding key
should exist. The requirements on the index and data layers are low: with minimal
effort, we were able to compose three highly scalable concurrent search data structures
based on three original data structures as the index layers with a batched version
of the Lazy List as the data layer. The resulting BatchBoost data structures provide
significant performance improvements over their original counterparts."
alternative_title:
- LIPIcs
article_number: '35'
article_processing_charge: Yes
author:
- first_name: Vitaly
full_name: Aksenov, Vitaly
last_name: Aksenov
- first_name: Michael
full_name: Anoprenko, Michael
last_name: Anoprenko
- first_name: Alexander
full_name: Fedorov, Alexander
id: 2e711909-896a-11ed-bdf8-eb0f5a2984c6
last_name: Fedorov
- first_name: Michael
full_name: Spear, Michael
last_name: Spear
citation:
ama: 'Aksenov V, Anoprenko M, Fedorov A, Spear M. Brief announcement: BatchBoost:
Universal batching for concurrent data structures. In: 37th International Symposium
on Distributed Computing. Vol 281. Schloss Dagstuhl - Leibniz-Zentrum für
Informatik; 2023. doi:10.4230/LIPIcs.DISC.2023.35'
apa: 'Aksenov, V., Anoprenko, M., Fedorov, A., & Spear, M. (2023). Brief announcement:
BatchBoost: Universal batching for concurrent data structures. In 37th International
Symposium on Distributed Computing (Vol. 281). L’Aquila, Italy: Schloss Dagstuhl
- Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.DISC.2023.35'
chicago: 'Aksenov, Vitaly, Michael Anoprenko, Alexander Fedorov, and Michael Spear.
“Brief Announcement: BatchBoost: Universal Batching for Concurrent Data Structures.”
In 37th International Symposium on Distributed Computing, Vol. 281. Schloss
Dagstuhl - Leibniz-Zentrum für Informatik, 2023. https://doi.org/10.4230/LIPIcs.DISC.2023.35.'
ieee: 'V. Aksenov, M. Anoprenko, A. Fedorov, and M. Spear, “Brief announcement:
BatchBoost: Universal batching for concurrent data structures,” in 37th International
Symposium on Distributed Computing, L’Aquila, Italy, 2023, vol. 281.'
ista: 'Aksenov V, Anoprenko M, Fedorov A, Spear M. 2023. Brief announcement: BatchBoost:
Universal batching for concurrent data structures. 37th International Symposium
on Distributed Computing. DISC: Symposium on Distributed Computing, LIPIcs, vol.
281, 35.'
mla: 'Aksenov, Vitaly, et al. “Brief Announcement: BatchBoost: Universal Batching
for Concurrent Data Structures.” 37th International Symposium on Distributed
Computing, vol. 281, 35, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2023, doi:10.4230/LIPIcs.DISC.2023.35.'
short: V. Aksenov, M. Anoprenko, A. Fedorov, M. Spear, in:, 37th International Symposium
on Distributed Computing, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2023.
conference:
end_date: 2023-10-13
location: L'Aquila, Italy
name: 'DISC: Symposium on Distributed Computing'
start_date: 2023-10-09
date_created: 2023-11-05T23:00:53Z
date_published: 2023-10-01T00:00:00Z
date_updated: 2023-11-07T07:48:01Z
day: '01'
ddc:
- '000'
department:
- _id: GradSch
doi: 10.4230/LIPIcs.DISC.2023.35
file:
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checksum: d9f8d2915cccdf2df5905b7cd1b4a560
content_type: application/pdf
creator: dernst
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date_updated: 2023-11-06T11:45:21Z
file_id: '14492'
file_name: 2023_LIPIcs_Aksenov.pdf
file_size: 646665
relation: main_file
success: 1
file_date_updated: 2023-11-06T11:45:21Z
has_accepted_license: '1'
intvolume: ' 281'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
publication: 37th International Symposium on Distributed Computing
publication_identifier:
isbn:
- '9783959773010'
issn:
- 1868-8969
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Brief announcement: BatchBoost: Universal batching for concurrent data structures'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 281
year: '2023'
...
---
_id: '12869'
abstract:
- lang: eng
text: 'We introduce a stochastic cellular automaton as a model for culture and border
formation. The model can be conceptualized as a game where the expansion rate
of cultures is quantified in terms of their area and perimeter in such a way that
approximately round cultures get a competitive advantage. We first analyse the
model with periodic boundary conditions, where we study how the model can end
up in a fixed state, i.e. freezes. Then we implement the model on the European
geography with mountains and rivers. We see how the model reproduces some qualitative
features of European culture formation, namely that rivers and mountains are more
frequently borders between cultures, mountainous regions tend to have higher cultural
diversity and the central European plain has less clear cultural borders. '
acknowledgement: 'FRK acknowledges support from the Villum Foundation for support
through the QMATH center of Excellence (Grant No. 10059) and the Villum Young Investigator
(Grant No. 25452) programs. '
article_processing_charge: No
author:
- first_name: Frederik Ravn
full_name: Klausen, Frederik Ravn
last_name: Klausen
- first_name: Asbjørn Bækgaard
full_name: Lauritsen, Asbjørn Bækgaard
id: e1a2682f-dc8d-11ea-abe3-81da9ac728f1
last_name: Lauritsen
orcid: 0000-0003-4476-2288
citation:
ama: 'Klausen FR, Lauritsen AB. Research data for: A stochastic cellular automaton
model of culture formation. 2023. doi:10.15479/AT:ISTA:12869'
apa: 'Klausen, F. R., & Lauritsen, A. B. (2023). Research data for: A stochastic
cellular automaton model of culture formation. Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:12869'
chicago: 'Klausen, Frederik Ravn, and Asbjørn Bækgaard Lauritsen. “Research Data
for: A Stochastic Cellular Automaton Model of Culture Formation.” Institute of
Science and Technology Austria, 2023. https://doi.org/10.15479/AT:ISTA:12869.'
ieee: 'F. R. Klausen and A. B. Lauritsen, “Research data for: A stochastic cellular
automaton model of culture formation.” Institute of Science and Technology Austria,
2023.'
ista: 'Klausen FR, Lauritsen AB. 2023. Research data for: A stochastic cellular
automaton model of culture formation, Institute of Science and Technology Austria,
10.15479/AT:ISTA:12869.'
mla: 'Klausen, Frederik Ravn, and Asbjørn Bækgaard Lauritsen. Research Data for:
A Stochastic Cellular Automaton Model of Culture Formation. Institute of Science
and Technology Austria, 2023, doi:10.15479/AT:ISTA:12869.'
short: F.R. Klausen, A.B. Lauritsen, (2023).
date_created: 2023-04-26T12:34:49Z
date_published: 2023-04-26T00:00:00Z
date_updated: 2023-11-13T07:47:29Z
day: '26'
ddc:
- '000'
department:
- _id: GradSch
- _id: RoSe
doi: 10.15479/AT:ISTA:12869
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date_created: 2023-04-26T12:30:06Z
date_updated: 2023-04-26T12:30:06Z
file_id: '12870'
file_name: README.md
file_size: 4567
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success: 1
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checksum: 25bf79452ae895f9c8a20571a096b4c3
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creator: alaurits
date_created: 2023-04-26T12:27:34Z
date_updated: 2023-04-26T12:27:34Z
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file_name: simulations_era=10_flux_varied_europe.zip
file_size: 732586731
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creator: alaurits
date_created: 2023-04-26T12:29:53Z
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success: 1
file_date_updated: 2023-04-26T12:30:06Z
has_accepted_license: '1'
license: https://creativecommons.org/publicdomain/zero/1.0/
month: '04'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '14505'
relation: used_in_publication
status: for_moderation
- id: '12890'
relation: used_in_publication
status: public
status: public
title: 'Research data for: A stochastic cellular automaton model of culture formation'
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12890'
abstract:
- lang: eng
text: We introduce a stochastic cellular automaton as a model for culture and border
formation. The model can be conceptualized as a game where the expansion rate
of cultures is quantified in terms of their area and perimeter in such a way that
approximately geometrically round cultures get a competitive advantage. We first
analyze the model with periodic boundary conditions, where we study how the model
can end up in a fixed state, i.e., freezes. Then we implement the model on the
European geography with mountains and rivers. We see how the model reproduces
some qualitative features of European culture formation, namely, that rivers and
mountains are more frequently borders between cultures, mountainous regions tend
to have higher cultural diversity, and the central European plain has less clear
cultural borders.
acknowledgement: Thanks to Kim Sneppen, Svend Krøjer, Peter Wildemann, Peter Rasmussen
and Kent Bækgaard Lauritsen for discussions and suggestions. FRK acknowledges support
from the Villum Foundation for support through the QMATH center of Excellence (Grant
No. 10059) and the Villum Young Investigator (Grant No. 25452) programs.
article_number: '054307'
article_processing_charge: No
article_type: original
author:
- first_name: Frederik Ravn
full_name: Klausen, Frederik Ravn
last_name: Klausen
- first_name: Asbjørn Bækgaard
full_name: Lauritsen, Asbjørn Bækgaard
id: e1a2682f-dc8d-11ea-abe3-81da9ac728f1
last_name: Lauritsen
orcid: 0000-0003-4476-2288
citation:
ama: Klausen FR, Lauritsen AB. Stochastic cellular automaton model of culture formation.
Physical Review E. 2023;108(5). doi:10.1103/PhysRevE.108.054307
apa: Klausen, F. R., & Lauritsen, A. B. (2023). Stochastic cellular automaton
model of culture formation. Physical Review E. American Physical Society.
https://doi.org/10.1103/PhysRevE.108.054307
chicago: Klausen, Frederik Ravn, and Asbjørn Bækgaard Lauritsen. “Stochastic Cellular
Automaton Model of Culture Formation.” Physical Review E. American Physical
Society, 2023. https://doi.org/10.1103/PhysRevE.108.054307.
ieee: F. R. Klausen and A. B. Lauritsen, “Stochastic cellular automaton model of
culture formation,” Physical Review E, vol. 108, no. 5. American Physical
Society, 2023.
ista: Klausen FR, Lauritsen AB. 2023. Stochastic cellular automaton model of culture
formation. Physical Review E. 108(5), 054307.
mla: Klausen, Frederik Ravn, and Asbjørn Bækgaard Lauritsen. “Stochastic Cellular
Automaton Model of Culture Formation.” Physical Review E, vol. 108, no.
5, 054307, American Physical Society, 2023, doi:10.1103/PhysRevE.108.054307.
short: F.R. Klausen, A.B. Lauritsen, Physical Review E 108 (2023).
date_created: 2023-05-04T08:35:01Z
date_published: 2023-11-08T00:00:00Z
date_updated: 2023-11-13T07:47:30Z
day: '08'
department:
- _id: GradSch
- _id: RoSe
doi: 10.1103/PhysRevE.108.054307
external_id:
arxiv:
- '2305.02153'
intvolume: ' 108'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2305.02153
month: '11'
oa: 1
oa_version: Preprint
publication: Physical Review E
publication_identifier:
eissn:
- 2470-0053
issn:
- 2470-0045
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/FrederikRavnKlausen/model-for-culture-formation
record:
- id: '12869'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Stochastic cellular automaton model of culture formation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 108
year: '2023'
...
---
_id: '14543'
abstract:
- lang: eng
text: The acyl-CoA-binding domain-containing protein 6 (ACBD6) is ubiquitously expressed,
plays a role in the acylation of lipids and proteins, and regulates the N-myristoylation
of proteins via N-myristoyltransferase enzymes (NMTs). However, its precise function
in cells is still unclear, as is the consequence of ACBD6 defects on human pathophysiology.
Utilizing exome sequencing and extensive international data sharing efforts, we
identified 45 affected individuals from 28 unrelated families (consanguinity 93%)
with bi-allelic pathogenic, predominantly loss-of-function (18/20) variants in
ACBD6. We generated zebrafish and Xenopus tropicalis acbd6 knockouts by CRISPR/Cas9
and characterized the role of ACBD6 on protein N-myristoylation with YnMyr chemical
proteomics in the model organisms and human cells, with the latter also being
subjected further to ACBD6 peroxisomal localization studies. The affected individuals
(23 males and 22 females), with ages ranging from 1 to 50 years old, typically
present with a complex and progressive disease involving moderate-to-severe global
developmental delay/intellectual disability (100%) with significant expressive
language impairment (98%), movement disorders (97%), facial dysmorphism (95%),
and mild cerebellar ataxia (85%) associated with gait impairment (94%), limb spasticity/hypertonia
(76%), oculomotor (71%) and behavioural abnormalities (65%), overweight (59%),
microcephaly (39%) and epilepsy (33%). The most conspicuous and common movement
disorder was dystonia (94%), frequently leading to early-onset progressive postural
deformities (97%), limb dystonia (55%), and cervical dystonia (31%). A jerky tremor
in the upper limbs (63%), a mild head tremor (59%), parkinsonism/hypokinesia developing
with advancing age (32%), and simple motor and vocal tics were among other frequent
movement disorders. Midline brain malformations including corpus callosum abnormalities
(70%), hypoplasia/agenesis of the anterior commissure (66%), short midbrain and
small inferior cerebellar vermis (38% each), as well as hypertrophy of the clava
(24%) were common neuroimaging findings. acbd6-deficient zebrafish and Xenopus
models effectively recapitulated many clinical phenotypes reported in patients
including movement disorders, progressive neuromotor impairment, seizures, microcephaly,
craniofacial dysmorphism, and midbrain defects accompanied by developmental delay
with increased mortality over time. Unlike ACBD5, ACBD6 did not show a peroxisomal
localisation and ACBD6-deficiency was not associated with altered peroxisomal
parameters in patient fibroblasts. Significant differences in YnMyr-labelling
were observed for 68 co- and 18 post-translationally N-myristoylated proteins
in patient-derived fibroblasts. N-Myristoylation was similarly affected in acbd6-deficient
zebrafish and Xenopus tropicalis models, including Fus, Marcks, and Chchd-related
proteins implicated in neurological diseases. The present study provides evidence
that bi-allelic pathogenic variants in ACBD6 lead to a distinct neurodevelopmental
syndrome accompanied by complex and progressive cognitive and movement disorders.
article_number: awad380
article_processing_charge: No
article_type: original
author:
- first_name: Rauan
full_name: Kaiyrzhanov, Rauan
last_name: Kaiyrzhanov
- first_name: Aboulfazl
full_name: Rad, Aboulfazl
last_name: Rad
- first_name: Sheng-Jia
full_name: Lin, Sheng-Jia
last_name: Lin
- first_name: Aida
full_name: Bertoli-Avella, Aida
last_name: Bertoli-Avella
- first_name: Wouter W
full_name: Kallemeijn, Wouter W
last_name: Kallemeijn
- first_name: Annie
full_name: Godwin, Annie
last_name: Godwin
- first_name: Maha S
full_name: Zaki, Maha S
last_name: Zaki
- first_name: Kevin
full_name: Huang, Kevin
id: 3b3d2888-1ff6-11ee-9fa6-8f209ca91fe3
last_name: Huang
orcid: 0000-0002-2512-7812
- first_name: Tracy
full_name: Lau, Tracy
last_name: Lau
- first_name: Cassidy
full_name: Petree, Cassidy
last_name: Petree
- first_name: Stephanie
full_name: Efthymiou, Stephanie
last_name: Efthymiou
- first_name: Ehsan
full_name: Ghayoor Karimiani, Ehsan
last_name: Ghayoor Karimiani
- first_name: Maja
full_name: Hempel, Maja
last_name: Hempel
- first_name: Elizabeth A
full_name: Normand, Elizabeth A
last_name: Normand
- first_name: Sabine
full_name: Rudnik-Schöneborn, Sabine
last_name: Rudnik-Schöneborn
- first_name: Ulrich A
full_name: Schatz, Ulrich A
last_name: Schatz
- first_name: Marc P
full_name: Baggelaar, Marc P
last_name: Baggelaar
- first_name: Muhammad
full_name: Ilyas, Muhammad
last_name: Ilyas
- first_name: Tipu
full_name: Sultan, Tipu
last_name: Sultan
- first_name: Javeria Raza
full_name: Alvi, Javeria Raza
last_name: Alvi
- first_name: Manizha
full_name: Ganieva, Manizha
last_name: Ganieva
- first_name: Ben
full_name: Fowler, Ben
last_name: Fowler
- first_name: Ruxandra
full_name: Aanicai, Ruxandra
last_name: Aanicai
- first_name: Gulsen
full_name: Akay Tayfun, Gulsen
last_name: Akay Tayfun
- first_name: Abdulaziz
full_name: Al Saman, Abdulaziz
last_name: Al Saman
- first_name: Abdulrahman
full_name: Alswaid, Abdulrahman
last_name: Alswaid
- first_name: Nafise
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last_name: Amiri
- first_name: Nilufar
full_name: Asilova, Nilufar
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- first_name: Vorasuk
full_name: Shotelersuk, Vorasuk
last_name: Shotelersuk
- first_name: Patra
full_name: Yeetong, Patra
last_name: Yeetong
- first_name: Matloob
full_name: Azam, Matloob
last_name: Azam
- first_name: Meisam
full_name: Babaei, Meisam
last_name: Babaei
- first_name: Gholamreza
full_name: Bahrami Monajemi, Gholamreza
last_name: Bahrami Monajemi
- first_name: Pouria
full_name: Mohammadi, Pouria
last_name: Mohammadi
- first_name: Saeed
full_name: Samie, Saeed
last_name: Samie
- first_name: Selina Husna
full_name: Banu, Selina Husna
last_name: Banu
- first_name: Jorge Pinto
full_name: Basto, Jorge Pinto
last_name: Basto
- first_name: Fanny
full_name: Kortüm, Fanny
last_name: Kortüm
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full_name: Bauer, Mislen
last_name: Bauer
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full_name: Bauer, Peter
last_name: Bauer
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full_name: Beetz, Christian
last_name: Beetz
- first_name: Masoud
full_name: Garshasbi, Masoud
last_name: Garshasbi
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full_name: Hameed Issa, Awatif
last_name: Hameed Issa
- first_name: Wafaa
full_name: Eyaid, Wafaa
last_name: Eyaid
- first_name: Hind
full_name: Ahmed, Hind
last_name: Ahmed
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full_name: Hashemi, Narges
last_name: Hashemi
- first_name: Kazem
full_name: Hassanpour, Kazem
last_name: Hassanpour
- first_name: Isabella
full_name: Herman, Isabella
last_name: Herman
- first_name: Sherozjon
full_name: Ibrohimov, Sherozjon
last_name: Ibrohimov
- first_name: Ban A
full_name: Abdul-Majeed, Ban A
last_name: Abdul-Majeed
- first_name: Maria
full_name: Imdad, Maria
last_name: Imdad
- first_name: Maksudjon
full_name: Isrofilov, Maksudjon
last_name: Isrofilov
- first_name: Qassem
full_name: Kaiyal, Qassem
last_name: Kaiyal
- first_name: Suliman
full_name: Khan, Suliman
last_name: Khan
- first_name: Brian
full_name: Kirmse, Brian
last_name: Kirmse
- first_name: Janet
full_name: Koster, Janet
last_name: Koster
- first_name: Charles Marques
full_name: Lourenço, Charles Marques
last_name: Lourenço
- first_name: Tadahiro
full_name: Mitani, Tadahiro
last_name: Mitani
- first_name: Oana
full_name: Moldovan, Oana
last_name: Moldovan
- first_name: David
full_name: Murphy, David
last_name: Murphy
- first_name: Maryam
full_name: Najafi, Maryam
last_name: Najafi
- first_name: Davut
full_name: Pehlivan, Davut
last_name: Pehlivan
- first_name: Maria Eugenia
full_name: Rocha, Maria Eugenia
last_name: Rocha
- first_name: Vincenzo
full_name: Salpietro, Vincenzo
last_name: Salpietro
- first_name: Miriam
full_name: Schmidts, Miriam
last_name: Schmidts
- first_name: Adel
full_name: Shalata, Adel
last_name: Shalata
- first_name: Mohammad
full_name: Mahroum, Mohammad
last_name: Mahroum
- first_name: Jawabreh Kassem
full_name: Talbeya, Jawabreh Kassem
last_name: Talbeya
- first_name: Robert W
full_name: Taylor, Robert W
last_name: Taylor
- first_name: Dayana
full_name: Vazquez, Dayana
last_name: Vazquez
- first_name: Annalisa
full_name: Vetro, Annalisa
last_name: Vetro
- first_name: Hans R
full_name: Waterham, Hans R
last_name: Waterham
- first_name: Mashaya
full_name: Zaman, Mashaya
last_name: Zaman
- first_name: Tina A
full_name: Schrader, Tina A
last_name: Schrader
- first_name: Wendy K
full_name: Chung, Wendy K
last_name: Chung
- first_name: Renzo
full_name: Guerrini, Renzo
last_name: Guerrini
- first_name: James R
full_name: Lupski, James R
last_name: Lupski
- first_name: Joseph
full_name: Gleeson, Joseph
last_name: Gleeson
- first_name: Mohnish
full_name: Suri, Mohnish
last_name: Suri
- first_name: Yalda
full_name: Jamshidi, Yalda
last_name: Jamshidi
- first_name: Kailash P
full_name: Bhatia, Kailash P
last_name: Bhatia
- first_name: Barbara
full_name: Vona, Barbara
last_name: Vona
- first_name: Michael
full_name: Schrader, Michael
last_name: Schrader
- first_name: Mariasavina
full_name: Severino, Mariasavina
last_name: Severino
- first_name: Matthew
full_name: Guille, Matthew
last_name: Guille
- first_name: Edward W
full_name: Tate, Edward W
last_name: Tate
- first_name: Gaurav K
full_name: Varshney, Gaurav K
last_name: Varshney
- first_name: Henry
full_name: Houlden, Henry
last_name: Houlden
- first_name: Reza
full_name: Maroofian, Reza
last_name: Maroofian
citation:
ama: Kaiyrzhanov R, Rad A, Lin S-J, et al. Bi-allelic ACBD6 variants lead to a neurodevelopmental
syndrome with progressive and complex movement disorders. Brain. 2023.
doi:10.1093/brain/awad380
apa: Kaiyrzhanov, R., Rad, A., Lin, S.-J., Bertoli-Avella, A., Kallemeijn, W. W.,
Godwin, A., … Maroofian, R. (2023). Bi-allelic ACBD6 variants lead to a neurodevelopmental
syndrome with progressive and complex movement disorders. Brain. Oxford
University Press. https://doi.org/10.1093/brain/awad380
chicago: Kaiyrzhanov, Rauan, Aboulfazl Rad, Sheng-Jia Lin, Aida Bertoli-Avella,
Wouter W Kallemeijn, Annie Godwin, Maha S Zaki, et al. “Bi-Allelic ACBD6 Variants
Lead to a Neurodevelopmental Syndrome with Progressive and Complex Movement Disorders.”
Brain. Oxford University Press, 2023. https://doi.org/10.1093/brain/awad380.
ieee: R. Kaiyrzhanov et al., “Bi-allelic ACBD6 variants lead to a neurodevelopmental
syndrome with progressive and complex movement disorders,” Brain. Oxford
University Press, 2023.
ista: Kaiyrzhanov R, Rad A, Lin S-J, Bertoli-Avella A, Kallemeijn WW, Godwin A,
Zaki MS, Huang K, Lau T, Petree C, Efthymiou S, Ghayoor Karimiani E, Hempel M,
Normand EA, Rudnik-Schöneborn S, Schatz UA, Baggelaar MP, Ilyas M, Sultan T, Alvi
JR, Ganieva M, Fowler B, Aanicai R, Akay Tayfun G, Al Saman A, Alswaid A, Amiri
N, Asilova N, Shotelersuk V, Yeetong P, Azam M, Babaei M, Bahrami Monajemi G,
Mohammadi P, Samie S, Banu SH, Basto JP, Kortüm F, Bauer M, Bauer P, Beetz C,
Garshasbi M, Hameed Issa A, Eyaid W, Ahmed H, Hashemi N, Hassanpour K, Herman
I, Ibrohimov S, Abdul-Majeed BA, Imdad M, Isrofilov M, Kaiyal Q, Khan S, Kirmse
B, Koster J, Lourenço CM, Mitani T, Moldovan O, Murphy D, Najafi M, Pehlivan D,
Rocha ME, Salpietro V, Schmidts M, Shalata A, Mahroum M, Talbeya JK, Taylor RW,
Vazquez D, Vetro A, Waterham HR, Zaman M, Schrader TA, Chung WK, Guerrini R, Lupski
JR, Gleeson J, Suri M, Jamshidi Y, Bhatia KP, Vona B, Schrader M, Severino M,
Guille M, Tate EW, Varshney GK, Houlden H, Maroofian R. 2023. Bi-allelic ACBD6
variants lead to a neurodevelopmental syndrome with progressive and complex movement
disorders. Brain., awad380.
mla: Kaiyrzhanov, Rauan, et al. “Bi-Allelic ACBD6 Variants Lead to a Neurodevelopmental
Syndrome with Progressive and Complex Movement Disorders.” Brain, awad380,
Oxford University Press, 2023, doi:10.1093/brain/awad380.
short: R. Kaiyrzhanov, A. Rad, S.-J. Lin, A. Bertoli-Avella, W.W. Kallemeijn, A.
Godwin, M.S. Zaki, K. Huang, T. Lau, C. Petree, S. Efthymiou, E. Ghayoor Karimiani,
M. Hempel, E.A. Normand, S. Rudnik-Schöneborn, U.A. Schatz, M.P. Baggelaar, M.
Ilyas, T. Sultan, J.R. Alvi, M. Ganieva, B. Fowler, R. Aanicai, G. Akay Tayfun,
A. Al Saman, A. Alswaid, N. Amiri, N. Asilova, V. Shotelersuk, P. Yeetong, M.
Azam, M. Babaei, G. Bahrami Monajemi, P. Mohammadi, S. Samie, S.H. Banu, J.P.
Basto, F. Kortüm, M. Bauer, P. Bauer, C. Beetz, M. Garshasbi, A. Hameed Issa,
W. Eyaid, H. Ahmed, N. Hashemi, K. Hassanpour, I. Herman, S. Ibrohimov, B.A. Abdul-Majeed,
M. Imdad, M. Isrofilov, Q. Kaiyal, S. Khan, B. Kirmse, J. Koster, C.M. Lourenço,
T. Mitani, O. Moldovan, D. Murphy, M. Najafi, D. Pehlivan, M.E. Rocha, V. Salpietro,
M. Schmidts, A. Shalata, M. Mahroum, J.K. Talbeya, R.W. Taylor, D. Vazquez, A.
Vetro, H.R. Waterham, M. Zaman, T.A. Schrader, W.K. Chung, R. Guerrini, J.R. Lupski,
J. Gleeson, M. Suri, Y. Jamshidi, K.P. Bhatia, B. Vona, M. Schrader, M. Severino,
M. Guille, E.W. Tate, G.K. Varshney, H. Houlden, R. Maroofian, Brain (2023).
date_created: 2023-11-16T12:36:51Z
date_published: 2023-11-10T00:00:00Z
date_updated: 2023-11-20T10:17:32Z
day: '10'
department:
- _id: GradSch
doi: 10.1093/brain/awad380
extern: '1'
keyword:
- Neurology (clinical)
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1093/brain/awad380
month: '11'
oa: 1
oa_version: Submitted Version
publication: Brain
publication_identifier:
eissn:
- 1460-2156
issn:
- 0006-8950
publication_status: epub_ahead
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Bi-allelic ACBD6 variants lead to a neurodevelopmental syndrome with progressive
and complex movement disorders
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '14542'
abstract:
- lang: eng
text: "It is a remarkable property of BCS theory that the ratio of the energy gap
at zero temperature Ξ\r\n and the critical temperature Tc is (approximately) given
by a universal constant, independent of the microscopic details of the fermionic
interaction. This universality has rigorously been proven quite recently in three
spatial dimensions and three different limiting regimes: weak coupling, low density
and high density. The goal of this short note is to extend the universal behavior
to lower dimensions d=1,2 and give an exemplary proof in the weak coupling limit."
acknowledgement: We thank Robert Seiringer for comments on the paper. J. H. gratefully
acknowledges partial financial support by the ERC Advanced Grant “RMTBeyond”No.
101020331.This research was funded in part by the Austrian Science Fund (FWF) grantnumber
I6427.
article_number: '2360005 '
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Sven Joscha
full_name: Henheik, Sven Joscha
id: 31d731d7-d235-11ea-ad11-b50331c8d7fb
last_name: Henheik
orcid: 0000-0003-1106-327X
- first_name: Asbjørn Bækgaard
full_name: Lauritsen, Asbjørn Bækgaard
id: e1a2682f-dc8d-11ea-abe3-81da9ac728f1
last_name: Lauritsen
orcid: 0000-0003-4476-2288
- first_name: Barbara
full_name: Roos, Barbara
id: 5DA90512-D80F-11E9-8994-2E2EE6697425
last_name: Roos
orcid: 0000-0002-9071-5880
citation:
ama: Henheik SJ, Lauritsen AB, Roos B. Universality in low-dimensional BCS theory.
Reviews in Mathematical Physics. 2023. doi:10.1142/s0129055x2360005x
apa: Henheik, S. J., Lauritsen, A. B., & Roos, B. (2023). Universality in low-dimensional
BCS theory. Reviews in Mathematical Physics. World Scientific Publishing.
https://doi.org/10.1142/s0129055x2360005x
chicago: Henheik, Sven Joscha, Asbjørn Bækgaard Lauritsen, and Barbara Roos. “Universality
in Low-Dimensional BCS Theory.” Reviews in Mathematical Physics. World
Scientific Publishing, 2023. https://doi.org/10.1142/s0129055x2360005x.
ieee: S. J. Henheik, A. B. Lauritsen, and B. Roos, “Universality in low-dimensional
BCS theory,” Reviews in Mathematical Physics. World Scientific Publishing,
2023.
ista: Henheik SJ, Lauritsen AB, Roos B. 2023. Universality in low-dimensional BCS
theory. Reviews in Mathematical Physics., 2360005.
mla: Henheik, Sven Joscha, et al. “Universality in Low-Dimensional BCS Theory.”
Reviews in Mathematical Physics, 2360005, World Scientific Publishing,
2023, doi:10.1142/s0129055x2360005x.
short: S.J. Henheik, A.B. Lauritsen, B. Roos, Reviews in Mathematical Physics (2023).
date_created: 2023-11-15T23:48:14Z
date_published: 2023-10-31T00:00:00Z
date_updated: 2023-11-20T10:04:38Z
day: '31'
department:
- _id: GradSch
- _id: LaEr
- _id: RoSe
doi: 10.1142/s0129055x2360005x
ec_funded: 1
external_id:
arxiv:
- '2301.05621'
has_accepted_license: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1142/S0129055X2360005X
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
- _id: bda63fe5-d553-11ed-ba76-a16e3d2f256b
grant_number: I06427
name: Mathematical Challenges in BCS Theory of Superconductivity
publication: Reviews in Mathematical Physics
publication_identifier:
eissn:
- 1793-6659
issn:
- 0129-055X
publication_status: epub_ahead
publisher: World Scientific Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Universality in low-dimensional BCS theory
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '14506'
abstract:
- lang: eng
text: "Payment channel networks are a promising approach to improve the scalability
bottleneck\r\nof cryptocurrencies. Two design principles behind payment channel
networks are\r\nefficiency and privacy. Payment channel networks improve efficiency
by allowing users\r\nto transact in a peer-to-peer fashion along multi-hop routes
in the network, avoiding\r\nthe lengthy process of consensus on the blockchain.
Transacting over payment channel\r\nnetworks also improves privacy as these transactions
are not broadcast to the blockchain.\r\nDespite the influx of recent protocols
built on top of payment channel networks and\r\ntheir analysis, a common shortcoming
of many of these protocols is that they typically\r\nfocus only on either improving
efficiency or privacy, but not both. Another limitation\r\non the efficiency front
is that the models used to model actions, costs and utilities of\r\nusers are
limited or come with unrealistic assumptions.\r\nThis thesis aims to address some
of the shortcomings of recent protocols and algorithms\r\non payment channel networks,
particularly in their privacy and efficiency aspects. We\r\nfirst present a payment
route discovery protocol based on hub labelling and private\r\ninformation retrieval
that hides the route query and is also efficient. We then present\r\na rebalancing
protocol that formulates the rebalancing problem as a linear program\r\nand solves
the linear program using multiparty computation so as to hide the channel\r\nbalances.
The rebalancing solution as output by our protocol is also globally optimal.\r\nWe
go on to develop more realistic models of the action space, costs, and utilities
of\r\nboth existing and new users that want to join the network. In each of these
settings,\r\nwe also develop algorithms to optimise the utility of these users
with good guarantees\r\non the approximation and competitive ratios."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Michelle X
full_name: Yeo, Michelle X
id: 2D82B818-F248-11E8-B48F-1D18A9856A87
last_name: Yeo
citation:
ama: Yeo MX. Advances in efficiency and privacy in payment channel network analysis.
2023. doi:10.15479/14506
apa: Yeo, M. X. (2023). Advances in efficiency and privacy in payment channel
network analysis. Institute of Science and Technology Austria. https://doi.org/10.15479/14506
chicago: Yeo, Michelle X. “Advances in Efficiency and Privacy in Payment Channel
Network Analysis.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/14506.
ieee: M. X. Yeo, “Advances in efficiency and privacy in payment channel network
analysis,” Institute of Science and Technology Austria, 2023.
ista: Yeo MX. 2023. Advances in efficiency and privacy in payment channel network
analysis. Institute of Science and Technology Austria.
mla: Yeo, Michelle X. Advances in Efficiency and Privacy in Payment Channel Network
Analysis. Institute of Science and Technology Austria, 2023, doi:10.15479/14506.
short: M.X. Yeo, Advances in Efficiency and Privacy in Payment Channel Network Analysis,
Institute of Science and Technology Austria, 2023.
date_created: 2023-11-10T08:10:43Z
date_published: 2023-11-10T00:00:00Z
date_updated: 2023-11-30T10:54:51Z
day: '10'
ddc:
- '000'
degree_awarded: PhD
department:
- _id: GradSch
- _id: KrPi
doi: 10.15479/14506
ec_funded: 1
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creator: cchlebak
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project:
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call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '9969'
relation: part_of_dissertation
status: public
- id: '13238'
relation: part_of_dissertation
status: public
- id: '14490'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Krzysztof Z
full_name: Pietrzak, Krzysztof Z
id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
last_name: Pietrzak
orcid: 0000-0002-9139-1654
title: Advances in efficiency and privacy in payment channel network analysis
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12726'
abstract:
- lang: eng
text: "Most motions of many-body systems at any scale in nature with sufficient
degrees\r\nof freedom tend to be chaotic; reaching from the orbital motion of
planets, the air\r\ncurrents in our atmosphere, down to the water flowing through
our pipelines or\r\nthe movement of a population of bacteria. To the observer
it is therefore intriguing\r\nwhen a moving collective exhibits order. Collective
motion of flocks of birds, schools\r\nof fish or swarms of self-propelled particles
or robots have been studied extensively\r\nover the past decades but the mechanisms
involved in the transition from chaos to\r\norder remain unclear. Here, the interactions,
that in most systems give rise to chaos,\r\nsustain order. In this thesis we investigate
mechanisms that preserve, destabilize\r\nor lead to the ordered state. We show
that endothelial cells migrating in circular\r\nconfinements transition to a collective
rotating state and concomitantly synchronize\r\nthe frequencies of nucleating
actin waves within individual cells. Consequently,\r\nthe frequency dependent
cell migration speed uniformizes across the population.\r\nComplementary to the
WAVE dependent nucleation of traveling actin waves, we\r\nshow that in leukocytes
the actin polymerization depending on WASp generates\r\npushing forces locally
at stationary patches. Next, in pipe flows, we study methods\r\nto disrupt the
self–sustaining cycle of turbulence and therefore relaminarize the\r\nflow. While
we find in pulsating flow conditions that turbulence emerges through a\r\nhelical
instability during the decelerating phase. Finally, we show quantitatively in\r\nbrain
slices of mice that wild-type control neurons can compensate the migratory\r\ndeficits
of a genetically modified neuronal sub–population in the developing cortex."
acknowledged_ssus:
- _id: M-Shop
- _id: Bio
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Michael
full_name: Riedl, Michael
id: 3BE60946-F248-11E8-B48F-1D18A9856A87
last_name: Riedl
orcid: 0000-0003-4844-6311
citation:
ama: Riedl M. Synchronization in collectively moving active matter. 2023. doi:10.15479/at:ista:12726
apa: Riedl, M. (2023). Synchronization in collectively moving active matter.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12726
chicago: Riedl, Michael. “Synchronization in Collectively Moving Active Matter.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:12726.
ieee: M. Riedl, “Synchronization in collectively moving active matter,” Institute
of Science and Technology Austria, 2023.
ista: Riedl M. 2023. Synchronization in collectively moving active matter. Institute
of Science and Technology Austria.
mla: Riedl, Michael. Synchronization in Collectively Moving Active Matter.
Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:12726.
short: M. Riedl, Synchronization in Collectively Moving Active Matter, Institute
of Science and Technology Austria, 2023.
date_created: 2023-03-15T13:22:13Z
date_published: 2023-03-23T00:00:00Z
date_updated: 2023-11-30T10:55:13Z
day: '23'
ddc:
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degree_awarded: PhD
department:
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- _id: BjHo
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date_created: 2023-03-23T12:49:23Z
date_updated: 2023-11-24T11:57:46Z
description: the main file is missing the bibliography. See new thesis record 14530
for updated files.
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publisher: Institute of Science and Technology Austria
related_material:
record:
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relation: part_of_dissertation
status: public
- id: '10791'
relation: part_of_dissertation
status: public
- id: '7932'
relation: part_of_dissertation
status: public
- id: '461'
relation: part_of_dissertation
status: public
- id: '14530'
relation: new_edition
status: public
status: public
supervisor:
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
title: Synchronization in collectively moving active matter
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14530'
abstract:
- lang: eng
text: 'Most motions of many-body systems at any scale in nature with sufficient
degrees of freedom tend to be chaotic; reaching from the orbital motion of planets,
the air currents in our atmosphere, down to the water flowing through our pipelines
or the movement of a population of bacteria. To the observer it is therefore intriguing
when a moving collective exhibits order. Collective motion of flocks of birds,
schools of fish or swarms of self-propelled particles or robots have been studied
extensively over the past decades but the mechanisms involved in the transition
from chaos to order remain unclear. Here, the interactions, that in most systems
give rise to chaos, sustain order. In this thesis we investigate mechanisms that
preserve, destabilize or lead to the ordered state. We show that endothelial cells
migrating in circular confinements transition to a collective rotating state and
concomitantly synchronize the frequencies of nucleating actin waves within individual
cells. Consequently, the frequency dependent cell migration speed uniformizes
across the population. Complementary to the WAVE dependent nucleation of traveling
actin waves, we show that in leukocytes the actin polymerization depending on
WASp generates pushing forces locally at stationary patches. Next, in pipe flows,
we study methods to disrupt the self--sustaining cycle of turbulence and therefore
relaminarize the flow. While we find in pulsating flow conditions that turbulence
emerges through a helical instability during the decelerating phase. Finally,
we show quantitatively in brain slices of mice that wild-type control neurons
can compensate the migratory deficits of a genetically modified neuronal sub--population
in the developing cortex. '
acknowledged_ssus:
- _id: M-Shop
- _id: Bio
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Michael
full_name: Riedl, Michael
id: 3BE60946-F248-11E8-B48F-1D18A9856A87
last_name: Riedl
orcid: 0000-0003-4844-6311
citation:
ama: Riedl M. Synchronization in collectively moving active matter. 2023. doi:10.15479/14530
apa: Riedl, M. (2023). Synchronization in collectively moving active matter.
Institute of Science and Technology Austria. https://doi.org/10.15479/14530
chicago: Riedl, Michael. “Synchronization in Collectively Moving Active Matter.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/14530.
ieee: M. Riedl, “Synchronization in collectively moving active matter,” Institute
of Science and Technology Austria, 2023.
ista: Riedl M. 2023. Synchronization in collectively moving active matter. Institute
of Science and Technology Austria.
mla: Riedl, Michael. Synchronization in Collectively Moving Active Matter.
Institute of Science and Technology Austria, 2023, doi:10.15479/14530.
short: M. Riedl, Synchronization in Collectively Moving Active Matter, Institute
of Science and Technology Austria, 2023.
date_created: 2023-11-15T09:59:03Z
date_published: 2023-11-16T00:00:00Z
date_updated: 2023-11-30T10:55:13Z
day: '16'
ddc:
- '530'
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: MiSi
doi: 10.15479/14530
file:
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checksum: 52e1d0ab6c1abe59c82dfe8c9ff5f83a
content_type: application/pdf
creator: mriedl
date_created: 2023-11-15T09:52:54Z
date_updated: 2023-11-15T09:52:54Z
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file_size: 36743942
relation: main_file
success: 1
file_date_updated: 2023-11-15T09:52:54Z
has_accepted_license: '1'
keyword:
- Synchronization
- Collective Movement
- Active Matter
- Cell Migration
- Active Colloids
language:
- iso: eng
month: '11'
oa: 1
oa_version: Updated Version
page: '260'
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '10703'
relation: part_of_dissertation
status: public
- id: '10791'
relation: part_of_dissertation
status: public
- id: '7932'
relation: part_of_dissertation
status: public
- id: '461'
relation: part_of_dissertation
status: public
- id: '12726'
relation: old_edition
status: public
status: public
supervisor:
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
title: Synchronization in collectively moving active matter
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14547'
abstract:
- lang: eng
text: "Superconductor-semiconductor heterostructures currently capture a significant
amount of research interest and they serve as the physical platform in many proposals
towards topological quantum computation.\r\nDespite being under extensive investigations,
historically using transport techniques, the basic properties of the interface
between the superconductor and the semiconductor remain to be understood.\r\n\r\nIn
this thesis, two separate studies on the Al-InAs heterostructures are reported
with the first focusing on the physics of the material motivated by the emergence
of a new phase, the Bogoliubov-Fermi surface. \r\nThe second focuses on a technological
application, a gate-tunable Josephson parametric amplifier.\r\n\r\nIn the first
study, we investigate the hypothesized unconventional nature of the induced superconductivity
at the interface between the Al thin film and the InAs quantum well.\r\nWe embed
a two-dimensional Al-InAs hybrid system in a resonant microwave circuit allowing
measurements of change in inductance.\r\nThe behaviour of the resonance in a range
of temperature and in-plane magnetic field has been studied and compared with
the theory of conventional s-wave superconductor and a two-component theory that
includes both contribution of the $s$-wave pairing in Al and the intraband $p
\\pm ip$ pairing in InAs.\r\nMeasuring the temperature dependence of resonant
frequency, no discrepancy is found between data and the conventional theory.\r\nWe
observe the breakdown of superconductivity due to an applied magnetic field which
contradicts the conventional theory.\r\nIn contrast, the data can be captured
quantitatively by fitting to a two-component model.\r\nWe find the evidence of
the intraband $p \\pm ip$ pairing in the InAs and the emergence of the Bogoliubov-Fermi
surfaces due to magnetic field with the characteristic value $B^* = 0.33~\\mathrm{T}$.\r\nFrom
the fits, the sheet resistance of Al, the carrier density and mobility in InAs
are determined.\r\nBy systematically studying the anisotropy of the circuit response,
we find weak anisotropy for $B < B^*$ and increasingly strong anisotropy for $B
> B^*$ resulting in a pronounced two-lobe structure in polar plot of frequency
versus field angle.\r\nStrong resemblance between the field dependence of dissipation
and superfluid density hints at a hidden signature of the Bogoliubov-Fermi surface
that is burried in the dissipation data.\r\n\r\nIn the second study, we realize
a parametric amplifier with a Josephson field effect transistor as the active
element.\r\nThe device's modest construction consists of a gated SNS weak link
embedded at the center of a coplanar waveguide resonator.\r\nBy applying a gate
voltage, the resonant frequency is field-effect tunable over a range of 2 GHz.\r\nModelling
the JoFET minimally as a parallel RL circuit, the dissipation introduced by the
JoFET can be quantitatively related to the gate voltage.\r\nWe observed gate-tunable
Kerr nonlinearity qualitatively in line with expectation.\r\nThe JoFET amplifier
has 20 dB of gain, 4 MHz of instantaneous bandwidth, and a 1dB compression point
of -125.5 dBm when operated at a fixed resonant frequency.\r\nIn general, the
signal-to-noise ratio is improved by 5-7 dB when the JoFET amplifier is activated
compared.\r\nThe noise of the measurement chain and insertion loss of relevant
circuit elements are calibrated to determine the expected and the real noise performance
of the JoFET amplifier.\r\nAs a quantification of the noise performance, the measured
total input-referred noise of the JoFET amplifier is in good agreement with the
estimated expectation which takes device loss into account.\r\nWe found that the
noise performance of the device reported in this document approaches one photon
of total input-referred added noise which is the quantum limit imposed in nondegenerate
parametric amplifier."
acknowledged_ssus:
- _id: NanoFab
- _id: Bio
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Duc T
full_name: Phan, Duc T
id: 29C8C0B4-F248-11E8-B48F-1D18A9856A87
last_name: Phan
citation:
ama: Phan DT. Resonant microwave spectroscopy of Al-InAs. 2023. doi:10.15479/14547
apa: Phan, D. T. (2023). Resonant microwave spectroscopy of Al-InAs. Institute
of Science and Technology Austria. https://doi.org/10.15479/14547
chicago: Phan, Duc T. “Resonant Microwave Spectroscopy of Al-InAs.” Institute of
Science and Technology Austria, 2023. https://doi.org/10.15479/14547.
ieee: D. T. Phan, “Resonant microwave spectroscopy of Al-InAs,” Institute of Science
and Technology Austria, 2023.
ista: Phan DT. 2023. Resonant microwave spectroscopy of Al-InAs. Institute of Science
and Technology Austria.
mla: Phan, Duc T. Resonant Microwave Spectroscopy of Al-InAs. Institute of
Science and Technology Austria, 2023, doi:10.15479/14547.
short: D.T. Phan, Resonant Microwave Spectroscopy of Al-InAs, Institute of Science
and Technology Austria, 2023.
date_created: 2023-11-17T13:45:26Z
date_published: 2023-11-16T00:00:00Z
date_updated: 2023-11-30T10:56:04Z
day: '16'
ddc:
- '530'
degree_awarded: PhD
department:
- _id: GradSch
- _id: AnHi
doi: 10.15479/14547
file:
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checksum: db0c37d213bc002125bd59690e9db246
content_type: application/pdf
creator: pduc
date_created: 2023-11-17T13:36:44Z
date_updated: 2023-11-22T09:46:06Z
file_id: '14548'
file_name: Phan_Thesis_pdfa.pdf
file_size: 34828019
relation: main_file
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checksum: 8d3bd6afa279a0078ffd13e06bb6d56d
content_type: application/zip
creator: pduc
date_created: 2023-11-17T13:44:53Z
date_updated: 2023-11-17T13:47:54Z
file_id: '14549'
file_name: dissertation_src.zip
file_size: 279319709
relation: source_file
file_date_updated: 2023-11-22T09:46:06Z
has_accepted_license: '1'
keyword:
- superconductor-semiconductor
- superconductivity
- Al
- InAs
- p-wave
- superconductivity
- JPA
- microwave
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: '80'
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '10851'
relation: part_of_dissertation
status: public
- id: '13264'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Andrew P
full_name: Higginbotham, Andrew P
id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
last_name: Higginbotham
orcid: 0000-0003-2607-2363
title: Resonant microwave spectroscopy of Al-InAs
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14628'
abstract:
- lang: eng
text: We introduce a compact, intuitive procedural graph representation for cellular
metamaterials, which are small-scale, tileable structures that can be architected
to exhibit many useful material properties. Because the structures’ “architectures”
vary widely—with elements such as beams, thin shells, and solid bulks—it is difficult
to explore them using existing representations. Generic approaches like voxel
grids are versatile, but it is cumbersome to represent and edit individual structures;
architecture-specific approaches address these issues, but are incompatible with
one another. By contrast, our procedural graph succinctly represents the construction
process for any structure using a simple skeleton annotated with spatially varying
thickness. To express the highly constrained triply periodic minimal surfaces
(TPMS) in this manner, we present the first fully automated version of the conjugate
surface construction method, which allows novices to create complex TPMS from
intuitive input. We demonstrate our representation’s expressiveness, accuracy,
and compactness by constructing a wide range of established structures and hundreds
of novel structures with diverse architectures and material properties. We also
conduct a user study to verify our representation’s ease-of-use and ability to
expand engineers’ capacity for exploration.
acknowledgement: "The authors thank Mina Konaković Luković and Michael Foshey for
their early contributions to this project, David Palmer and Paul Zhang for their
insightful discussions about minimal surfaces and the CSCM, Julian Panetta for providing
the Elastic Textures code, and Hannes Hergeth for his feedback and support. We also
thank our user study participants and anonymous reviewers.\r\nThis material is based
upon work supported by the National Science Foundation\r\n(NSF) Graduate Research
Fellowship under Grant No. 2141064; the MIT Morningside\r\nAcademy for Design Fellowship;
the Defense Advanced Research Projects Agency\r\n(DARPA) Grant No. FA8750-20-C-0075;
the ERC Consolidator Grant No. 101045083,\r\n“CoDiNA: Computational Discovery of
Numerical Algorithms for Animation and Simulation of Natural Phenomena”; and the
NewSat project, which is co-funded by the Operational Program for Competitiveness
and Internationalisation (COMPETE2020), Portugal 2020, the European Regional Development
Fund (ERDF), and the Portuguese Foundation for Science and Technology (FTC) under
the MIT Portugal program."
article_number: '168'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Liane
full_name: Makatura, Liane
last_name: Makatura
- first_name: Bohan
full_name: Wang, Bohan
last_name: Wang
- first_name: Yi-Lu
full_name: Chen, Yi-Lu
id: 0b467602-dbcd-11ea-9d1d-ed480aa46b70
last_name: Chen
- first_name: Bolei
full_name: Deng, Bolei
last_name: Deng
- first_name: Christopher J
full_name: Wojtan, Christopher J
id: 3C61F1D2-F248-11E8-B48F-1D18A9856A87
last_name: Wojtan
orcid: 0000-0001-6646-5546
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
- first_name: Wojciech
full_name: Matusik, Wojciech
last_name: Matusik
citation:
ama: 'Makatura L, Wang B, Chen Y-L, et al. Procedural metamaterials: A unified procedural
graph for metamaterial design. ACM Transactions on Graphics. 2023;42(5).
doi:10.1145/3605389'
apa: 'Makatura, L., Wang, B., Chen, Y.-L., Deng, B., Wojtan, C., Bickel, B., &
Matusik, W. (2023). Procedural metamaterials: A unified procedural graph for metamaterial
design. ACM Transactions on Graphics. Association for Computing Machinery.
https://doi.org/10.1145/3605389'
chicago: 'Makatura, Liane, Bohan Wang, Yi-Lu Chen, Bolei Deng, Chris Wojtan, Bernd
Bickel, and Wojciech Matusik. “Procedural Metamaterials: A Unified Procedural
Graph for Metamaterial Design.” ACM Transactions on Graphics. Association
for Computing Machinery, 2023. https://doi.org/10.1145/3605389.'
ieee: 'L. Makatura et al., “Procedural metamaterials: A unified procedural
graph for metamaterial design,” ACM Transactions on Graphics, vol. 42,
no. 5. Association for Computing Machinery, 2023.'
ista: 'Makatura L, Wang B, Chen Y-L, Deng B, Wojtan C, Bickel B, Matusik W. 2023.
Procedural metamaterials: A unified procedural graph for metamaterial design.
ACM Transactions on Graphics. 42(5), 168.'
mla: 'Makatura, Liane, et al. “Procedural Metamaterials: A Unified Procedural Graph
for Metamaterial Design.” ACM Transactions on Graphics, vol. 42, no. 5,
168, Association for Computing Machinery, 2023, doi:10.1145/3605389.'
short: L. Makatura, B. Wang, Y.-L. Chen, B. Deng, C. Wojtan, B. Bickel, W. Matusik,
ACM Transactions on Graphics 42 (2023).
date_created: 2023-11-29T15:02:03Z
date_published: 2023-10-01T00:00:00Z
date_updated: 2023-12-04T08:09:05Z
day: '01'
ddc:
- '531'
- '006'
department:
- _id: GradSch
- _id: ChWo
- _id: BeBi
doi: 10.1145/3605389
file:
- access_level: open_access
checksum: 0192f597d7a2ceaf89baddfd6190d4c8
content_type: application/zip
creator: yichen
date_created: 2023-11-29T15:16:01Z
date_updated: 2023-11-29T15:16:01Z
file_id: '14630'
file_name: tog-22-0089-File004.zip
file_size: 95467870
relation: main_file
success: 1
- access_level: open_access
checksum: 7fb024963be81933494f38de191e4710
content_type: application/zip
creator: yichen
date_created: 2023-11-29T15:16:01Z
date_updated: 2023-11-29T15:16:01Z
file_id: '14631'
file_name: tog-22-0089-File005.zip
file_size: 103731880
relation: main_file
success: 1
- access_level: open_access
checksum: b7d6829ce396e21cac9fae0ec7130a6b
content_type: application/pdf
creator: dernst
date_created: 2023-12-04T08:04:14Z
date_updated: 2023-12-04T08:04:14Z
file_id: '14638'
file_name: 2023_ACMToG_Makatura.pdf
file_size: 57067476
relation: main_file
success: 1
file_date_updated: 2023-12-04T08:04:14Z
has_accepted_license: '1'
intvolume: ' 42'
issue: '5'
keyword:
- Computer Graphics and Computer-Aided Design
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 34bc2376-11ca-11ed-8bc3-9a3b3961a088
grant_number: '101045083'
name: Computational Discovery of Numerical Algorithms for Animation and Simulation
of Natural Phenomena
publication: ACM Transactions on Graphics
publication_identifier:
issn:
- 0730-0301
- 1557-7368
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
status: public
title: 'Procedural metamaterials: A unified procedural graph for metamaterial design'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 42
year: '2023'
...
---
_id: '14653'
abstract:
- lang: eng
text: 'Mass spectrometry imaging (MSI) is a powerful analytical technique for the
two-dimensional (2D) localization of chemicals on surfaces. Conventional MSI experiments
require to predefine the surface of interest based on photographic or microscopic
images. Typically, these boundaries can no longer be changed or adjusted once
the experiment has been started. In terms of a more interactive approach we recently
developed a pen-like ionization interface which is directly connected to the mass
spectrometer. The device allows the user to ionize chemicals by desorption electrospray
ionization (DESI) and to freely move the interface over a surface of interest.
A mini camera, which is mounted on the tip of the pen, magnifies the desorption
area and enables a simple positioning of the pen. The combination of optical data
from the camera module and chemical data obtained by mass analysis facilitates
a novel type of imaging experiment: interactive mass spectrometry imaging (IMSI).
For this application, we present a novel approach for a robust, optical flow-based
motion detection. While the live video stream from the camera is used to track
the pen''s motion across the surface a post-acquisition algorithm correlates the
coordinates of the pen trajectory with respective mass spectra obtained from a
simultaneous mass spectrometric data acquisition. This algorithm is no longer
dependent on a single, manually applied optical marker on the sample surface,
which has to be visible on all video frames throughout the analysis. The advanced
DESI-IMSI method was successfully tested on inkjet-printed letters as well as
mouse brain tissue samples. Validation of the results was done by comparing DESI-IMSI
with standard DESI-MSI data.'
acknowledgement: We would like to thank Marco Sealey Cardona, PhD for help with the
mouse brain samples and acknowledge the financial support by 1669 Förderkreis of
the University of Innsbruck, Austria Wirtschaftsservice (AWS), D. Swarovski KG and
Tyrolean Science Fund (TWF).
article_number: '117168'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Florian
full_name: Kluibenschedl, Florian
id: 7499e70e-eb2c-11ec-b98b-f925648bc9d9
last_name: Kluibenschedl
- first_name: Anna
full_name: Ploner, Anna
last_name: Ploner
- first_name: Christina
full_name: Meisenbichler, Christina
last_name: Meisenbichler
- first_name: Robert
full_name: Konrat, Robert
last_name: Konrat
- first_name: Thomas
full_name: Müller, Thomas
last_name: Müller
citation:
ama: Kluibenschedl F, Ploner A, Meisenbichler C, Konrat R, Müller T. Advanced motion
tracking for interactive mass spectrometry imaging (IMSI). International Journal
of Mass Spectrometry. 2023;495. doi:10.1016/j.ijms.2023.117168
apa: Kluibenschedl, F., Ploner, A., Meisenbichler, C., Konrat, R., & Müller,
T. (2023). Advanced motion tracking for interactive mass spectrometry imaging
(IMSI). International Journal of Mass Spectrometry. Elsevier. https://doi.org/10.1016/j.ijms.2023.117168
chicago: Kluibenschedl, Florian, Anna Ploner, Christina Meisenbichler, Robert Konrat,
and Thomas Müller. “Advanced Motion Tracking for Interactive Mass Spectrometry
Imaging (IMSI).” International Journal of Mass Spectrometry. Elsevier,
2023. https://doi.org/10.1016/j.ijms.2023.117168.
ieee: F. Kluibenschedl, A. Ploner, C. Meisenbichler, R. Konrat, and T. Müller, “Advanced
motion tracking for interactive mass spectrometry imaging (IMSI),” International
Journal of Mass Spectrometry, vol. 495. Elsevier, 2023.
ista: Kluibenschedl F, Ploner A, Meisenbichler C, Konrat R, Müller T. 2023. Advanced
motion tracking for interactive mass spectrometry imaging (IMSI). International
Journal of Mass Spectrometry. 495, 117168.
mla: Kluibenschedl, Florian, et al. “Advanced Motion Tracking for Interactive Mass
Spectrometry Imaging (IMSI).” International Journal of Mass Spectrometry,
vol. 495, 117168, Elsevier, 2023, doi:10.1016/j.ijms.2023.117168.
short: F. Kluibenschedl, A. Ploner, C. Meisenbichler, R. Konrat, T. Müller, International
Journal of Mass Spectrometry 495 (2023).
date_created: 2023-12-10T23:00:57Z
date_published: 2023-11-23T00:00:00Z
date_updated: 2023-12-11T08:16:35Z
day: '23'
department:
- _id: GradSch
doi: 10.1016/j.ijms.2023.117168
intvolume: ' 495'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.ijms.2023.117168
month: '11'
oa: 1
oa_version: Published Version
publication: International Journal of Mass Spectrometry
publication_identifier:
issn:
- 1387-3806
publication_status: epub_ahead
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Advanced motion tracking for interactive mass spectrometry imaging (IMSI)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 495
year: '2023'
...
---
_id: '13274'
abstract:
- lang: eng
text: Viscous flows through pipes and channels are steady and ordered until, with
increasing velocity, the laminar motion catastrophically breaks down and gives
way to turbulence. How this apparently discontinuous change from low- to high-dimensional
motion can be rationalized within the framework of the Navier-Stokes equations
is not well understood. Exploiting geometrical properties of transitional channel
flow we trace turbulence to far lower Reynolds numbers (Re) than previously possible
and identify the complete path that reversibly links fully turbulent motion to
an invariant solution. This precursor of turbulence destabilizes rapidly with
Re, and the accompanying explosive increase in attractor dimension effectively
marks the transition between deterministic and de facto stochastic dynamics.
acknowledgement: We thank Baofang Song as well as the developers of Channelflow for
sharing their numerical codes, and Mukund Vasudevan and Holger Kantz for fruitful
discussions. This work was supported by a grant from the Simons Foundation (662960,
B. H.).
article_number: '034002'
article_processing_charge: No
article_type: original
author:
- first_name: Chaitanya S
full_name: Paranjape, Chaitanya S
id: 3D85B7C4-F248-11E8-B48F-1D18A9856A87
last_name: Paranjape
- first_name: Gökhan
full_name: Yalniz, Gökhan
id: 66E74FA2-D8BF-11E9-8249-8DE2E5697425
last_name: Yalniz
orcid: 0000-0002-8490-9312
- first_name: Yohann
full_name: Duguet, Yohann
last_name: Duguet
- first_name: Nazmi B
full_name: Budanur, Nazmi B
id: 3EA1010E-F248-11E8-B48F-1D18A9856A87
last_name: Budanur
orcid: 0000-0003-0423-5010
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
citation:
ama: Paranjape CS, Yalniz G, Duguet Y, Budanur NB, Hof B. Direct path from turbulence
to time-periodic solutions. Physical Review Letters. 2023;131(3). doi:10.1103/physrevlett.131.034002
apa: Paranjape, C. S., Yalniz, G., Duguet, Y., Budanur, N. B., & Hof, B. (2023).
Direct path from turbulence to time-periodic solutions. Physical Review Letters.
American Physical Society. https://doi.org/10.1103/physrevlett.131.034002
chicago: Paranjape, Chaitanya S, Gökhan Yalniz, Yohann Duguet, Nazmi B Budanur,
and Björn Hof. “Direct Path from Turbulence to Time-Periodic Solutions.” Physical
Review Letters. American Physical Society, 2023. https://doi.org/10.1103/physrevlett.131.034002.
ieee: C. S. Paranjape, G. Yalniz, Y. Duguet, N. B. Budanur, and B. Hof, “Direct
path from turbulence to time-periodic solutions,” Physical Review Letters,
vol. 131, no. 3. American Physical Society, 2023.
ista: Paranjape CS, Yalniz G, Duguet Y, Budanur NB, Hof B. 2023. Direct path from
turbulence to time-periodic solutions. Physical Review Letters. 131(3), 034002.
mla: Paranjape, Chaitanya S., et al. “Direct Path from Turbulence to Time-Periodic
Solutions.” Physical Review Letters, vol. 131, no. 3, 034002, American
Physical Society, 2023, doi:10.1103/physrevlett.131.034002.
short: C.S. Paranjape, G. Yalniz, Y. Duguet, N.B. Budanur, B. Hof, Physical Review
Letters 131 (2023).
date_created: 2023-07-24T09:43:59Z
date_published: 2023-07-21T00:00:00Z
date_updated: 2023-12-13T11:40:19Z
day: '21'
department:
- _id: GradSch
- _id: BjHo
doi: 10.1103/physrevlett.131.034002
external_id:
arxiv:
- '2306.05098'
isi:
- '001052929900004'
intvolume: ' 131'
isi: 1
issue: '3'
keyword:
- General Physics and Astronomy
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2306.05098
month: '07'
oa: 1
oa_version: Preprint
project:
- _id: 238598C6-32DE-11EA-91FC-C7463DDC885E
grant_number: '662960'
name: 'Revisiting the Turbulence Problem Using Statistical Mechanics: Experimental
Studies on Transitional and Turbulent Flows'
publication: Physical Review Letters
publication_identifier:
eissn:
- 1079-7114
issn:
- 0031-9007
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
status: public
title: Direct path from turbulence to time-periodic solutions
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 131
year: '2023'
...
---
_id: '14058'
abstract:
- lang: eng
text: "Females and males across species are subject to divergent selective pressures
arising\r\nfrom di↵erent reproductive interests and ecological niches. This often
translates into a\r\nintricate array of sex-specific natural and sexual selection
on traits that have a shared\r\ngenetic basis between both sexes, causing a genetic
sexual conflict. The resolution of\r\nthis conflict mostly relies on the evolution
of sex-specific expression of the shared genes,\r\nleading to phenotypic sexual
dimorphism. Such sex-specific gene expression is thought\r\nto evolve via modifications
of the genetic networks ultimately linked to sex-determining\r\ntranscription
factors. Although much empirical and theoretical evidence supports this\r\nstandard
picture of the molecular basis of sexual conflict resolution, there still are
a\r\nfew open questions regarding the complex array of selective forces driving
phenotypic\r\ndi↵erentiation between the sexes, as well as the molecular mechanisms
underlying sexspecific adaptation. I address some of these open questions in my
PhD thesis.\r\nFirst, how do patterns of phenotypic sexual dimorphism vary within
populations,\r\nas a response to the temporal and spatial changes in sex-specific
selective forces? To\r\ntackle this question, I analyze the patterns of sex-specific
phenotypic variation along\r\nthree life stages and across populations spanning
the whole geographical range of Rumex\r\nhastatulus, a wind-pollinated angiosperm,
in the first Chapter of the thesis.\r\nSecond, how do gene expression patterns
lead to phenotypic dimorphism, and what\r\nare the molecular mechanisms underlying
the observed transcriptomic variation? I\r\naddress this question by examining
the sex- and tissue-specific expression variation in\r\nnewly-generated datasets
of sex-specific expression in heads and gonads of Drosophila\r\nmelanogaster.
I additionally used two complementary approaches for the study of the\r\ngenetic
basis of sex di↵erences in gene expression in the second and third Chapters of\r\nthe
thesis.\r\nThird, how does intersex correlation, thought to be one of the main
aspects constraining the ability for the two sexes to decouple, interact with
the evolution of sexual\r\ndimorphism? I develop models of sex-specific stabilizing
selection, mutation and drift\r\nto formalize common intuition regarding the patterns
of covariation between intersex\r\ncorrelation and sexual dimorphism in the fourth
Chapter of the thesis.\r\nAlltogether, the work described in this PhD thesis provides
useful insights into the\r\nlinks between genetic, transcriptomic and phenotypic
layers of sex-specific variation,\r\nand contributes to our general understanding
of the dynamics of sexual dimorphism\r\nevolution."
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Gemma
full_name: Puixeu Sala, Gemma
id: 33AB266C-F248-11E8-B48F-1D18A9856A87
last_name: Puixeu Sala
orcid: 0000-0001-8330-1754
citation:
ama: 'Puixeu Sala G. The molecular basis of sexual dimorphism: Experimental and
theoretical characterization of phenotypic, transcriptomic and genetic patterns
of sex-specific adaptation. 2023. doi:10.15479/at:ista:14058'
apa: 'Puixeu Sala, G. (2023). The molecular basis of sexual dimorphism: Experimental
and theoretical characterization of phenotypic, transcriptomic and genetic patterns
of sex-specific adaptation. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14058'
chicago: 'Puixeu Sala, Gemma. “The Molecular Basis of Sexual Dimorphism: Experimental
and Theoretical Characterization of Phenotypic, Transcriptomic and Genetic Patterns
of Sex-Specific Adaptation.” Institute of Science and Technology Austria, 2023.
https://doi.org/10.15479/at:ista:14058.'
ieee: 'G. Puixeu Sala, “The molecular basis of sexual dimorphism: Experimental and
theoretical characterization of phenotypic, transcriptomic and genetic patterns
of sex-specific adaptation,” Institute of Science and Technology Austria, 2023.'
ista: 'Puixeu Sala G. 2023. The molecular basis of sexual dimorphism: Experimental
and theoretical characterization of phenotypic, transcriptomic and genetic patterns
of sex-specific adaptation. Institute of Science and Technology Austria.'
mla: 'Puixeu Sala, Gemma. The Molecular Basis of Sexual Dimorphism: Experimental
and Theoretical Characterization of Phenotypic, Transcriptomic and Genetic Patterns
of Sex-Specific Adaptation. Institute of Science and Technology Austria, 2023,
doi:10.15479/at:ista:14058.'
short: 'G. Puixeu Sala, The Molecular Basis of Sexual Dimorphism: Experimental and
Theoretical Characterization of Phenotypic, Transcriptomic and Genetic Patterns
of Sex-Specific Adaptation, Institute of Science and Technology Austria, 2023.'
date_created: 2023-08-15T10:20:40Z
date_published: 2023-08-15T00:00:00Z
date_updated: 2023-12-13T12:15:36Z
day: '15'
ddc:
- '576'
degree_awarded: PhD
department:
- _id: GradSch
- _id: NiBa
- _id: BeVi
doi: 10.15479/at:ista:14058
ec_funded: 1
file:
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checksum: 4e44e169f2724ee8c9324cd60bcc2b71
content_type: application/zip
creator: gpuixeus
date_created: 2023-08-16T18:15:17Z
date_updated: 2023-08-17T06:55:24Z
file_id: '14075'
file_name: Thesis_latex_forpdfa.zip
file_size: 10891454
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date_created: 2023-08-18T10:47:55Z
date_updated: 2023-08-18T10:47:55Z
file_id: '14079'
file_name: PhDThesis_PuixeuG.pdf
file_size: 19856686
relation: main_file
success: 1
file_date_updated: 2023-08-18T10:47:55Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '230'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 9B9DFC9E-BA93-11EA-9121-9846C619BF3A
grant_number: '25817'
name: 'Sexual conflict: resolution, constraints and biomedical implications'
publication_identifier:
isbn:
- 978-3-99078-035-0
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '9803'
relation: research_data
status: public
- id: '12933'
relation: research_data
status: public
- id: '6831'
relation: part_of_dissertation
status: public
- id: '14077'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
title: 'The molecular basis of sexual dimorphism: Experimental and theoretical characterization
of phenotypic, transcriptomic and genetic patterns of sex-specific adaptation'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14077'
abstract:
- lang: eng
text: "The regulatory architecture of gene expression is known to differ substantially
between sexes in Drosophila, but most studies performed\r\nso far used whole-body
data and only single crosses, which may have limited their scope to detect patterns
that are robust across tissues\r\nand biological replicates. Here, we use allele-specific
gene expression of parental and reciprocal hybrid crosses between 6 Drosophila\r\nmelanogaster
inbred lines to quantify cis- and trans-regulatory variation in heads and gonads
of both sexes separately across 3 replicate\r\ncrosses. Our results suggest that
female and male heads, as well as ovaries, have a similar regulatory architecture.
On the other hand,\r\ntestes display more and substantially different cis-regulatory
effects, suggesting that sex differences in the regulatory architecture that\r\nhave
been previously observed may largely derive from testis-specific effects. We also
examine the difference in cis-regulatory variation\r\nof genes across different
levels of sex bias in gonads and heads. Consistent with the idea that intersex
correlations constrain expression\r\nand can lead to sexual antagonism, we find
more cis variation in unbiased and moderately biased genes in heads. In ovaries,
reduced cis\r\nvariation is observed for male-biased genes, suggesting that cis
variants acting on these genes in males do not lead to changes in ovary\r\nexpression.
Finally, we examine the dominance patterns of gene expression and find that sex-
and tissue-specific patterns of inheritance\r\nas well as trans-regulatory variation
are highly variable across biological crosses, although these were performed in
highly controlled\r\nexperimental conditions. This highlights the importance of
using various genetic backgrounds to infer generalizable patterns."
acknowledged_ssus:
- _id: ScienComp
acknowledgement: We thank members of the Vicoso Group for comments on the manuscript,
the Scientific Computing Unit at ISTA for technical support, and 2 anonymous reviewers
for useful feedback. GP is the recipient of a DOC Fellowship of the Austrian Academy
of Sciences at the Institute of Science and Technology Austria (DOC 25817) and received
funding from the European Union’s Horizon 2020 research and innovation program under
the Marie Skłodowska-Curie Grant (agreement no. 665385).
article_processing_charge: Yes
article_type: original
author:
- first_name: Gemma
full_name: Puixeu Sala, Gemma
id: 33AB266C-F248-11E8-B48F-1D18A9856A87
last_name: Puixeu Sala
orcid: 0000-0001-8330-1754
- first_name: Ariana
full_name: Macon, Ariana
id: 2A0848E2-F248-11E8-B48F-1D18A9856A87
last_name: Macon
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
citation:
ama: 'Puixeu Sala G, Macon A, Vicoso B. Sex-specific estimation of cis and trans
regulation of gene expression in heads and gonads of Drosophila melanogaster.
G3: Genes, Genomes, Genetics. 2023;13(8). doi:10.1093/g3journal/jkad121'
apa: 'Puixeu Sala, G., Macon, A., & Vicoso, B. (2023). Sex-specific estimation
of cis and trans regulation of gene expression in heads and gonads of Drosophila
melanogaster. G3: Genes, Genomes, Genetics. Oxford University Press. https://doi.org/10.1093/g3journal/jkad121'
chicago: 'Puixeu Sala, Gemma, Ariana Macon, and Beatriz Vicoso. “Sex-Specific Estimation
of Cis and Trans Regulation of Gene Expression in Heads and Gonads of Drosophila
Melanogaster.” G3: Genes, Genomes, Genetics. Oxford University Press, 2023.
https://doi.org/10.1093/g3journal/jkad121.'
ieee: 'G. Puixeu Sala, A. Macon, and B. Vicoso, “Sex-specific estimation of cis
and trans regulation of gene expression in heads and gonads of Drosophila melanogaster,”
G3: Genes, Genomes, Genetics, vol. 13, no. 8. Oxford University Press,
2023.'
ista: 'Puixeu Sala G, Macon A, Vicoso B. 2023. Sex-specific estimation of cis and
trans regulation of gene expression in heads and gonads of Drosophila melanogaster.
G3: Genes, Genomes, Genetics. 13(8).'
mla: 'Puixeu Sala, Gemma, et al. “Sex-Specific Estimation of Cis and Trans Regulation
of Gene Expression in Heads and Gonads of Drosophila Melanogaster.” G3: Genes,
Genomes, Genetics, vol. 13, no. 8, Oxford University Press, 2023, doi:10.1093/g3journal/jkad121.'
short: 'G. Puixeu Sala, A. Macon, B. Vicoso, G3: Genes, Genomes, Genetics 13 (2023).'
date_created: 2023-08-18T06:52:14Z
date_published: 2023-08-01T00:00:00Z
date_updated: 2023-12-13T12:15:37Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
- _id: NiBa
- _id: GradSch
doi: 10.1093/g3journal/jkad121
ec_funded: 1
external_id:
isi:
- '001002997200001'
file:
- access_level: open_access
checksum: c62e29fc7c5efbf8356f4c60cab4a2d1
content_type: application/pdf
creator: dernst
date_created: 2023-11-07T09:00:19Z
date_updated: 2023-11-07T09:00:19Z
file_id: '14498'
file_name: 2023_G3_Puixeu.pdf
file_size: 845642
relation: main_file
success: 1
file_date_updated: 2023-11-07T09:00:19Z
has_accepted_license: '1'
intvolume: ' 13'
isi: 1
issue: '8'
keyword:
- Genetics (clinical)
- Genetics
- Molecular Biology
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 9B9DFC9E-BA93-11EA-9121-9846C619BF3A
grant_number: '25817'
name: 'Sexual conflict: resolution, constraints and biomedical implications'
publication: 'G3: Genes, Genomes, Genetics'
publication_identifier:
issn:
- 2160-1836
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
record:
- id: '12933'
relation: research_data
status: public
- id: '14058'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: Sex-specific estimation of cis and trans regulation of gene expression in heads
and gonads of Drosophila melanogaster
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13
year: '2023'
...
---
_id: '12933'
abstract:
- lang: eng
text: Datasets of the publication "Sex-specific estimation of cis and trans regulation
of gene expression in heads and gonads of Drosophila melanogaster".
article_processing_charge: No
author:
- first_name: Gemma
full_name: Puixeu Sala, Gemma
id: 33AB266C-F248-11E8-B48F-1D18A9856A87
last_name: Puixeu Sala
orcid: 0000-0001-8330-1754
citation:
ama: 'Puixeu Sala G. Data from: Sex-specific estimation of cis and trans regulation
of gene expression in heads and gonads of Drosophila melanogaster. 2023. doi:10.15479/AT:ISTA:12933'
apa: 'Puixeu Sala, G. (2023). Data from: Sex-specific estimation of cis and trans
regulation of gene expression in heads and gonads of Drosophila melanogaster.
Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:12933'
chicago: 'Puixeu Sala, Gemma. “Data from: Sex-Specific Estimation of Cis and Trans
Regulation of Gene Expression in Heads and Gonads of Drosophila Melanogaster.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/AT:ISTA:12933.'
ieee: 'G. Puixeu Sala, “Data from: Sex-specific estimation of cis and trans regulation
of gene expression in heads and gonads of Drosophila melanogaster.” Institute
of Science and Technology Austria, 2023.'
ista: 'Puixeu Sala G. 2023. Data from: Sex-specific estimation of cis and trans
regulation of gene expression in heads and gonads of Drosophila melanogaster,
Institute of Science and Technology Austria, 10.15479/AT:ISTA:12933.'
mla: 'Puixeu Sala, Gemma. Data from: Sex-Specific Estimation of Cis and Trans
Regulation of Gene Expression in Heads and Gonads of Drosophila Melanogaster.
Institute of Science and Technology Austria, 2023, doi:10.15479/AT:ISTA:12933.'
short: G. Puixeu Sala, (2023).
contributor:
- first_name: Ariana
id: 2A0848E2-F248-11E8-B48F-1D18A9856A87
last_name: Macon
- first_name: Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
date_created: 2023-05-10T10:00:49Z
date_published: 2023-05-15T00:00:00Z
date_updated: 2023-12-13T12:15:36Z
day: '15'
ddc:
- '570'
department:
- _id: GradSch
- _id: NiBa
- _id: BeVi
doi: 10.15479/AT:ISTA:12933
file:
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content_type: text/csv
creator: gpuixeus
date_created: 2023-05-10T09:41:43Z
date_updated: 2023-05-10T09:41:43Z
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file_size: 8029982
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file_size: 4566
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month: '05'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '14058'
relation: used_in_publication
status: public
- id: '14077'
relation: used_in_publication
status: public
status: public
title: 'Data from: Sex-specific estimation of cis and trans regulation of gene expression
in heads and gonads of Drosophila melanogaster'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '14343'
abstract:
- lang: eng
text: The total energy of an eigenstate in a composite quantum system tends to be
distributed equally among its constituents. We identify the quantum fluctuation
around this equipartition principle in the simplest disordered quantum system
consisting of linear combinations of Wigner matrices. As our main ingredient,
we prove the Eigenstate Thermalisation Hypothesis and Gaussian fluctuation for
general quadratic forms of the bulk eigenvectors of Wigner matrices with an arbitrary
deformation.
acknowledgement: "G.C. and L.E. gratefully acknowledge many discussions with Dominik
Schröder at the preliminary stage of this project, especially his essential contribution
to identify the correct generalisation of traceless observables to the deformed
Wigner ensembles.\r\nL.E. and J.H. acknowledges support by ERC Advanced Grant ‘RMTBeyond’
No. 101020331."
article_number: e74
article_processing_charge: Yes
article_type: original
author:
- first_name: Giorgio
full_name: Cipolloni, Giorgio
id: 42198EFA-F248-11E8-B48F-1D18A9856A87
last_name: Cipolloni
orcid: 0000-0002-4901-7992
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Sven Joscha
full_name: Henheik, Sven Joscha
id: 31d731d7-d235-11ea-ad11-b50331c8d7fb
last_name: Henheik
orcid: 0000-0003-1106-327X
- first_name: Oleksii
full_name: Kolupaiev, Oleksii
id: 149b70d4-896a-11ed-bdf8-8c63fd44ca61
last_name: Kolupaiev
citation:
ama: Cipolloni G, Erdös L, Henheik SJ, Kolupaiev O. Gaussian fluctuations in the
equipartition principle for Wigner matrices. Forum of Mathematics, Sigma.
2023;11. doi:10.1017/fms.2023.70
apa: Cipolloni, G., Erdös, L., Henheik, S. J., & Kolupaiev, O. (2023). Gaussian
fluctuations in the equipartition principle for Wigner matrices. Forum of Mathematics,
Sigma. Cambridge University Press. https://doi.org/10.1017/fms.2023.70
chicago: Cipolloni, Giorgio, László Erdös, Sven Joscha Henheik, and Oleksii Kolupaiev.
“Gaussian Fluctuations in the Equipartition Principle for Wigner Matrices.” Forum
of Mathematics, Sigma. Cambridge University Press, 2023. https://doi.org/10.1017/fms.2023.70.
ieee: G. Cipolloni, L. Erdös, S. J. Henheik, and O. Kolupaiev, “Gaussian fluctuations
in the equipartition principle for Wigner matrices,” Forum of Mathematics,
Sigma, vol. 11. Cambridge University Press, 2023.
ista: Cipolloni G, Erdös L, Henheik SJ, Kolupaiev O. 2023. Gaussian fluctuations
in the equipartition principle for Wigner matrices. Forum of Mathematics, Sigma.
11, e74.
mla: Cipolloni, Giorgio, et al. “Gaussian Fluctuations in the Equipartition Principle
for Wigner Matrices.” Forum of Mathematics, Sigma, vol. 11, e74, Cambridge
University Press, 2023, doi:10.1017/fms.2023.70.
short: G. Cipolloni, L. Erdös, S.J. Henheik, O. Kolupaiev, Forum of Mathematics,
Sigma 11 (2023).
date_created: 2023-09-17T22:01:09Z
date_published: 2023-08-23T00:00:00Z
date_updated: 2023-12-13T12:24:23Z
day: '23'
ddc:
- '510'
department:
- _id: LaEr
- _id: GradSch
doi: 10.1017/fms.2023.70
ec_funded: 1
external_id:
arxiv:
- '2301.05181'
isi:
- '001051980200001'
file:
- access_level: open_access
checksum: eb747420e6a88a7796fa934151957676
content_type: application/pdf
creator: dernst
date_created: 2023-09-20T11:09:35Z
date_updated: 2023-09-20T11:09:35Z
file_id: '14352'
file_name: 2023_ForumMathematics_Cipolloni.pdf
file_size: 852652
relation: main_file
success: 1
file_date_updated: 2023-09-20T11:09:35Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication: Forum of Mathematics, Sigma
publication_identifier:
eissn:
- 2050-5094
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Gaussian fluctuations in the equipartition principle for Wigner matrices
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2023'
...
---
_id: '14421'
abstract:
- lang: eng
text: Only recently has it been possible to construct a self-adjoint Hamiltonian
that involves the creation of Dirac particles at a point source in 3d space. Its
definition makes use of an interior-boundary condition. Here, we develop for this
Hamiltonian a corresponding theory of the Bohmian configuration. That is, we (non-rigorously)
construct a Markov jump process $(Q_t)_{t\in\mathbb{R}}$ in the configuration
space of a variable number of particles that is $|\psi_t|^2$-distributed at every
time t and follows Bohmian trajectories between the jumps. The jumps correspond
to particle creation or annihilation events and occur either to or from a configuration
with a particle located at the source. The process is the natural analog of Bell's
jump process, and a central piece in its construction is the determination of
the rate of particle creation. The construction requires an analysis of the asymptotic
behavior of the Bohmian trajectories near the source. We find that the particle
reaches the source with radial speed 0, but orbits around the source infinitely
many times in finite time before absorption (or after emission).
acknowledgement: J H gratefully acknowledges partial financial support by the ERC
Advanced Grant 'RMTBeyond' No. 101020331.
article_number: '445201'
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Sven Joscha
full_name: Henheik, Sven Joscha
id: 31d731d7-d235-11ea-ad11-b50331c8d7fb
last_name: Henheik
orcid: 0000-0003-1106-327X
- first_name: Roderich
full_name: Tumulka, Roderich
last_name: Tumulka
citation:
ama: 'Henheik SJ, Tumulka R. Creation rate of Dirac particles at a point source.
Journal of Physics A: Mathematical and Theoretical. 2023;56(44). doi:10.1088/1751-8121/acfe62'
apa: 'Henheik, S. J., & Tumulka, R. (2023). Creation rate of Dirac particles
at a point source. Journal of Physics A: Mathematical and Theoretical.
IOP Publishing. https://doi.org/10.1088/1751-8121/acfe62'
chicago: 'Henheik, Sven Joscha, and Roderich Tumulka. “Creation Rate of Dirac Particles
at a Point Source.” Journal of Physics A: Mathematical and Theoretical.
IOP Publishing, 2023. https://doi.org/10.1088/1751-8121/acfe62.'
ieee: 'S. J. Henheik and R. Tumulka, “Creation rate of Dirac particles at a point
source,” Journal of Physics A: Mathematical and Theoretical, vol. 56, no.
44. IOP Publishing, 2023.'
ista: 'Henheik SJ, Tumulka R. 2023. Creation rate of Dirac particles at a point
source. Journal of Physics A: Mathematical and Theoretical. 56(44), 445201.'
mla: 'Henheik, Sven Joscha, and Roderich Tumulka. “Creation Rate of Dirac Particles
at a Point Source.” Journal of Physics A: Mathematical and Theoretical,
vol. 56, no. 44, 445201, IOP Publishing, 2023, doi:10.1088/1751-8121/acfe62.'
short: 'S.J. Henheik, R. Tumulka, Journal of Physics A: Mathematical and Theoretical
56 (2023).'
date_created: 2023-10-12T12:42:53Z
date_published: 2023-10-11T00:00:00Z
date_updated: 2023-12-13T13:01:25Z
day: '11'
ddc:
- '510'
department:
- _id: GradSch
- _id: LaEr
doi: 10.1088/1751-8121/acfe62
ec_funded: 1
external_id:
arxiv:
- '2211.16606'
isi:
- '001080908000001'
file:
- access_level: open_access
checksum: 5b68de147dd4c608b71a6e0e844d2ce9
content_type: application/pdf
creator: dernst
date_created: 2023-10-16T07:07:24Z
date_updated: 2023-10-16T07:07:24Z
file_id: '14429'
file_name: 2023_JourPhysics_Henheik.pdf
file_size: 721399
relation: main_file
success: 1
file_date_updated: 2023-10-16T07:07:24Z
has_accepted_license: '1'
intvolume: ' 56'
isi: 1
issue: '44'
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication: 'Journal of Physics A: Mathematical and Theoretical'
publication_identifier:
eissn:
- 1751-8121
issn:
- 1751-8113
publication_status: published
publisher: IOP Publishing
quality_controlled: '1'
scopus_import: '1'
status: public
title: Creation rate of Dirac particles at a point source
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 56
year: '2023'
...
---
_id: '14425'
abstract:
- lang: eng
text: 'Water adsorption and dissociation processes on pristine low-index TiO2 interfaces
are important but poorly understood outside the well-studied anatase (101) and
rutile (110). To understand these, we construct three sets of machine learning
potentials that are simultaneously applicable to various TiO2 surfaces, based
on three density-functional-theory approximations. Here we show the water dissociation
free energies on seven pristine TiO2 surfaces, and predict that anatase (100),
anatase (110), rutile (001), and rutile (011) favor water dissociation, anatase
(101) and rutile (100) have mostly molecular adsorption, while the simulations
of rutile (110) sensitively depend on the slab thickness and molecular adsorption
is preferred with thick slabs. Moreover, using an automated algorithm, we reveal
that these surfaces follow different types of atomistic mechanisms for proton
transfer and water dissociation: one-step, two-step, or both. These mechanisms
can be rationalized based on the arrangements of water molecules on the different
surfaces. Our finding thus demonstrates that the different pristine TiO2 surfaces
react with water in distinct ways, and cannot be represented using just the low-energy
anatase (101) and rutile (110) surfaces.'
acknowledgement: F.S., J.H., and B.C. thank the Swiss National Supercomputing Centre
(CSCS) for the generous allocation of CPU hours via production project s1108 at
the Piz Daint supercomputer. B.C. acknowledges resources provided by the Cambridge
Tier-2 system operated by the University of Cambridge Research Computing Service
funded by EPSRC Tier-2 capital grant EP/P020259/1. J.C. acknowledges the Beijing
Natural Science Foundation for support under grant No. JQ22001. F.S., and J.H. thank
the Swiss Platform for Advanced Scientific Computing (PASC) via the 2021-2024 “Ab
Initio Molecular Dynamics at the Exa-Scale” project. This project has received funding
from the European Union’s Horizon 2020 research and innovation programme under the
Marie Skłodowska-Curie grant agreement No 101034413.
article_number: '6131'
article_processing_charge: Yes
article_type: original
author:
- first_name: Zezhu
full_name: Zeng, Zezhu
id: 54a2c730-803f-11ed-ab7e-95b29d2680e7
last_name: Zeng
- first_name: Felix
full_name: Wodaczek, Felix
id: 8b4b6a9f-32b0-11ee-9fa8-bbe85e26258e
last_name: Wodaczek
orcid: 0009-0000-1457-795X
- first_name: Keyang
full_name: Liu, Keyang
last_name: Liu
- first_name: Frederick
full_name: Stein, Frederick
last_name: Stein
- first_name: Jürg
full_name: Hutter, Jürg
last_name: Hutter
- first_name: Ji
full_name: Chen, Ji
last_name: Chen
- first_name: Bingqing
full_name: Cheng, Bingqing
id: cbe3cda4-d82c-11eb-8dc7-8ff94289fcc9
last_name: Cheng
orcid: 0000-0002-3584-9632
citation:
ama: Zeng Z, Wodaczek F, Liu K, et al. Mechanistic insight on water dissociation
on pristine low-index TiO2 surfaces from machine learning molecular dynamics simulations.
Nature Communications. 2023;14. doi:10.1038/s41467-023-41865-8
apa: Zeng, Z., Wodaczek, F., Liu, K., Stein, F., Hutter, J., Chen, J., & Cheng,
B. (2023). Mechanistic insight on water dissociation on pristine low-index TiO2
surfaces from machine learning molecular dynamics simulations. Nature Communications.
Springer Nature. https://doi.org/10.1038/s41467-023-41865-8
chicago: Zeng, Zezhu, Felix Wodaczek, Keyang Liu, Frederick Stein, Jürg Hutter,
Ji Chen, and Bingqing Cheng. “Mechanistic Insight on Water Dissociation on Pristine
Low-Index TiO2 Surfaces from Machine Learning Molecular Dynamics Simulations.”
Nature Communications. Springer Nature, 2023. https://doi.org/10.1038/s41467-023-41865-8.
ieee: Z. Zeng et al., “Mechanistic insight on water dissociation on pristine
low-index TiO2 surfaces from machine learning molecular dynamics simulations,”
Nature Communications, vol. 14. Springer Nature, 2023.
ista: Zeng Z, Wodaczek F, Liu K, Stein F, Hutter J, Chen J, Cheng B. 2023. Mechanistic
insight on water dissociation on pristine low-index TiO2 surfaces from machine
learning molecular dynamics simulations. Nature Communications. 14, 6131.
mla: Zeng, Zezhu, et al. “Mechanistic Insight on Water Dissociation on Pristine
Low-Index TiO2 Surfaces from Machine Learning Molecular Dynamics Simulations.”
Nature Communications, vol. 14, 6131, Springer Nature, 2023, doi:10.1038/s41467-023-41865-8.
short: Z. Zeng, F. Wodaczek, K. Liu, F. Stein, J. Hutter, J. Chen, B. Cheng, Nature
Communications 14 (2023).
date_created: 2023-10-15T22:01:10Z
date_published: 2023-10-02T00:00:00Z
date_updated: 2023-12-13T13:02:07Z
day: '02'
ddc:
- '540'
- '000'
department:
- _id: BiCh
- _id: GradSch
doi: 10.1038/s41467-023-41865-8
ec_funded: 1
external_id:
arxiv:
- '2303.07433'
isi:
- '001084354900008'
pmid:
- '37783698'
file:
- access_level: open_access
checksum: 7d1dffd36b672ec679f08f70ce79da87
content_type: application/pdf
creator: dernst
date_created: 2023-10-16T07:34:49Z
date_updated: 2023-10-16T07:34:49Z
file_id: '14432'
file_name: 2023_NatureComm_Zeng.pdf
file_size: 3194116
relation: main_file
success: 1
file_date_updated: 2023-10-16T07:34:49Z
has_accepted_license: '1'
intvolume: ' 14'
isi: 1
language:
- iso: eng
month: '10'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: fc2ed2f7-9c52-11eb-aca3-c01059dda49c
call_identifier: H2020
grant_number: '101034413'
name: 'IST-BRIDGE: International postdoctoral program'
publication: Nature Communications
publication_identifier:
eissn:
- 2041-1723
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/BingqingCheng/TiO2-water
scopus_import: '1'
status: public
title: Mechanistic insight on water dissociation on pristine low-index TiO2 surfaces
from machine learning molecular dynamics simulations
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 14
year: '2023'
...
---
_id: '14622'
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Stefan
full_name: Sack, Stefan
id: dd622248-f6e0-11ea-865d-ce382a1c81a5
last_name: Sack
orcid: 0000-0001-5400-8508
citation:
ama: 'Sack S. Improving variational quantum algorithms: Innovative initialization
techniques and extensions to qudit systems. 2023. doi:10.15479/at:ista:14622'
apa: 'Sack, S. (2023). Improving variational quantum algorithms: Innovative initialization
techniques and extensions to qudit systems. Institute of Science and Technology
Austria. https://doi.org/10.15479/at:ista:14622'
chicago: 'Sack, Stefan. “Improving Variational Quantum Algorithms: Innovative Initialization
Techniques and Extensions to Qudit Systems.” Institute of Science and Technology
Austria, 2023. https://doi.org/10.15479/at:ista:14622.'
ieee: 'S. Sack, “Improving variational quantum algorithms: Innovative initialization
techniques and extensions to qudit systems,” Institute of Science and Technology
Austria, 2023.'
ista: 'Sack S. 2023. Improving variational quantum algorithms: Innovative initialization
techniques and extensions to qudit systems. Institute of Science and Technology
Austria.'
mla: 'Sack, Stefan. Improving Variational Quantum Algorithms: Innovative Initialization
Techniques and Extensions to Qudit Systems. Institute of Science and Technology
Austria, 2023, doi:10.15479/at:ista:14622.'
short: 'S. Sack, Improving Variational Quantum Algorithms: Innovative Initialization
Techniques and Extensions to Qudit Systems, Institute of Science and Technology
Austria, 2023.'
date_created: 2023-11-28T10:58:13Z
date_published: 2023-11-30T00:00:00Z
date_updated: 2023-12-13T14:47:25Z
day: '30'
ddc:
- '530'
degree_awarded: PhD
department:
- _id: GradSch
- _id: MaSe
doi: 10.15479/at:ista:14622
ec_funded: 1
file:
- access_level: closed
checksum: 068fd3570506ec42b2faa390de784bc4
content_type: application/pdf
creator: ssack
date_created: 2023-11-30T15:53:10Z
date_updated: 2023-12-01T11:10:46Z
embargo: 2024-11-30
embargo_to: open_access
file_id: '14635'
file_name: PhD_Thesis.pdf
file_size: 11947523
relation: main_file
- access_level: closed
checksum: 0fa3bc0d108aed0ac59d2c6beef2220a
content_type: application/zip
creator: ssack
date_created: 2023-11-30T15:54:11Z
date_updated: 2023-12-01T11:10:46Z
file_id: '14636'
file_name: PhD Thesis (1).zip
file_size: 18422964
relation: source_file
file_date_updated: 2023-12-01T11:10:46Z
has_accepted_license: '1'
language:
- iso: eng
month: '11'
oa_version: Published Version
page: '142'
project:
- _id: bd660c93-d553-11ed-ba76-fb0fb6f49c0d
name: Quantum_Quantum Circuits and Software_Variational quantum algorithms on NISQ
devices
- _id: 23841C26-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '850899'
name: 'Non-Ergodic Quantum Matter: Universality, Dynamics and Control'
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '11471'
relation: part_of_dissertation
status: public
- id: '13125'
relation: part_of_dissertation
status: public
- id: '9760'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Maksym
full_name: Serbyn, Maksym
id: 47809E7E-F248-11E8-B48F-1D18A9856A87
last_name: Serbyn
orcid: 0000-0002-2399-5827
title: 'Improving variational quantum algorithms: Innovative initialization techniques
and extensions to qudit systems'
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14697'
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Julian A
full_name: Stopp, Julian A
id: 489E3F00-F248-11E8-B48F-1D18A9856A87
last_name: Stopp
citation:
ama: 'Stopp JA. Neutrophils on the hunt: Migratory strategies employed by neutrophils
to fulfill their effector function. 2023. doi:10.15479/at:ista:14697'
apa: 'Stopp, J. A. (2023). Neutrophils on the hunt: Migratory strategies employed
by neutrophils to fulfill their effector function. Institute of Science and
Technology Austria. https://doi.org/10.15479/at:ista:14697'
chicago: 'Stopp, Julian A. “Neutrophils on the Hunt: Migratory Strategies Employed
by Neutrophils to Fulfill Their Effector Function.” Institute of Science and Technology
Austria, 2023. https://doi.org/10.15479/at:ista:14697.'
ieee: 'J. A. Stopp, “Neutrophils on the hunt: Migratory strategies employed by neutrophils
to fulfill their effector function,” Institute of Science and Technology Austria,
2023.'
ista: 'Stopp JA. 2023. Neutrophils on the hunt: Migratory strategies employed by
neutrophils to fulfill their effector function. Institute of Science and Technology
Austria.'
mla: 'Stopp, Julian A. Neutrophils on the Hunt: Migratory Strategies Employed
by Neutrophils to Fulfill Their Effector Function. Institute of Science and
Technology Austria, 2023, doi:10.15479/at:ista:14697.'
short: 'J.A. Stopp, Neutrophils on the Hunt: Migratory Strategies Employed by Neutrophils
to Fulfill Their Effector Function, Institute of Science and Technology Austria,
2023.'
date_created: 2023-12-18T19:14:28Z
date_published: 2023-12-20T00:00:00Z
date_updated: 2023-12-21T14:30:02Z
day: '20'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: MiSi
doi: 10.15479/at:ista:14697
ec_funded: 1
file:
- access_level: closed
checksum: 457927165d5d556305d3086f6b83e5c7
content_type: application/pdf
creator: jstopp
date_created: 2023-12-20T09:35:34Z
date_updated: 2023-12-20T09:35:34Z
embargo: 2024-12-20
embargo_to: open_access
file_id: '14699'
file_name: Thesis.pdf
file_size: 51585778
relation: main_file
- access_level: closed
checksum: e8d26449ac461f5e8478a62c9507506f
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: jstopp
date_created: 2023-12-20T09:35:35Z
date_updated: 2023-12-20T10:41:42Z
file_id: '14700'
file_name: Thesis.docx
file_size: 69625950
relation: source_file
file_date_updated: 2023-12-20T10:41:42Z
has_accepted_license: '1'
language:
- iso: eng
month: '12'
oa_version: Published Version
page: '226'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
isbn:
- 978-3-99078-038-1
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '6328'
relation: part_of_dissertation
status: public
- id: '7885'
relation: part_of_dissertation
status: public
- id: '12272'
relation: part_of_dissertation
status: public
- id: '14274'
relation: part_of_dissertation
status: public
- id: '14360'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
title: 'Neutrophils on the hunt: Migratory strategies employed by neutrophils to fulfill
their effector function'
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14651'
abstract:
- lang: eng
text: 'For self-incompatibility (SI) to be stable in a population, theory predicts
that sufficient inbreeding depression (ID) is required: the fitness of offspring
from self-mated individuals must be low enough to prevent the spread of self-compatibility
(SC). Reviews of natural plant populations have supported this theory, with SI
species generally showing high levels of ID. However, there is thought to be an
under-sampling of self-incompatible taxa in the current literature. In this thesis,
I study inbreeding depression in the SI plant species Antirrhinum majus using
both greenhouse crosses and a large collected field dataset. Additionally, the
gametophytic S-locus of A. majus is highly heterozygous and polymorphic, thus
making assembly and discovery of S-alleles very difficult. Here, 206 new alleles
of the male component SLFs are presented, along with a phylogeny showing the high
conservation with alleles from another Antirrhinum species. Lastly, selected sites
within the protein structure of SLFs are investigated, with one site in particular
highlighted as potentially being involved in the SI recognition mechanism.'
acknowledged_ssus:
- _id: ScienComp
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Louise S
full_name: Arathoon, Louise S
id: 2CFCFF98-F248-11E8-B48F-1D18A9856A87
last_name: Arathoon
orcid: 0000-0003-1771-714X
citation:
ama: Arathoon LS. Investigating inbreeding depression and the self-incompatibility
locus of Antirrhinum majus. 2023. doi:10.15479/at:ista:14651
apa: Arathoon, L. S. (2023). Investigating inbreeding depression and the self-incompatibility
locus of Antirrhinum majus. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14651
chicago: Arathoon, Louise S. “Investigating Inbreeding Depression and the Self-Incompatibility
Locus of Antirrhinum Majus.” Institute of Science and Technology Austria, 2023.
https://doi.org/10.15479/at:ista:14651.
ieee: L. S. Arathoon, “Investigating inbreeding depression and the self-incompatibility
locus of Antirrhinum majus,” Institute of Science and Technology Austria, 2023.
ista: Arathoon LS. 2023. Investigating inbreeding depression and the self-incompatibility
locus of Antirrhinum majus. Institute of Science and Technology Austria.
mla: Arathoon, Louise S. Investigating Inbreeding Depression and the Self-Incompatibility
Locus of Antirrhinum Majus. Institute of Science and Technology Austria, 2023,
doi:10.15479/at:ista:14651.
short: L.S. Arathoon, Investigating Inbreeding Depression and the Self-Incompatibility
Locus of Antirrhinum Majus, Institute of Science and Technology Austria, 2023.
date_created: 2023-12-11T19:30:37Z
date_published: 2023-12-12T00:00:00Z
date_updated: 2023-12-22T11:04:45Z
day: '12'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: NiBa
doi: 10.15479/at:ista:14651
ec_funded: 1
file:
- access_level: open_access
checksum: 520bdb61e95e66070e02824947d2c5fa
content_type: application/pdf
creator: larathoo
date_created: 2023-12-13T15:37:55Z
date_updated: 2023-12-13T15:37:55Z
file_id: '14684'
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file_size: 34101468
relation: main_file
success: 1
- access_level: closed
checksum: d8e59afd0817c98fba2564a264508e5c
content_type: application/zip
creator: larathoo
date_created: 2023-12-13T15:42:23Z
date_updated: 2023-12-14T08:58:18Z
file_id: '14685'
file_name: Phd_Thesis_LA.zip
file_size: 31052872
relation: source_file
- access_level: closed
checksum: 9a778c949932286f4519e1f1fca2820d
content_type: application/zip
creator: larathoo
date_created: 2023-12-11T19:24:59Z
date_updated: 2023-12-14T08:58:18Z
file_id: '14681'
file_name: Supplementary_Materials.zip
file_size: 10713896
relation: supplementary_material
file_date_updated: 2023-12-14T08:58:18Z
has_accepted_license: '1'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: '96'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '11411'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
title: Investigating inbreeding depression and the self-incompatibility locus of Antirrhinum
majus
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14703'
abstract:
- lang: eng
text: We present a discretization of the dynamic optimal transport problem for which
we can obtain the convergence rate for the value of the transport cost to its
continuous value when the temporal and spatial stepsize vanish. This convergence
result does not require any regularity assumption on the measures, though experiments
suggest that the rate is not sharp. Via an analysis of the duality gap we also
obtain the convergence rates for the gradient of the optimal potentials and the
velocity field under mild regularity assumptions. To obtain such rates we discretize
the dual formulation of the dynamic optimal transport problem and use the mature
literature related to the error due to discretizing the Hamilton-Jacobi equation.
acknowledgement: "The authors would like to thank Chris Wojtan for his continuous
support and several interesting discussions. Part of this research was performed
during two visits: one of SI to the BIDSA research center at Bocconi University,
and one of HL to the Institute of Science and Technology Austria. Both host institutions
are warmly acknowledged for the hospital-\r\nity. HL is partially supported by the
MUR-Prin 2022-202244A7YL “Gradient Flows and Non-Smooth Geometric Structures with
Applications to Optimization and Machine Learning”, funded by the European Union
- Next Generation EU. SI is supported in part by ERC Consolidator Grant 101045083
“CoDiNA” funded by the European Research Council."
article_number: '2312.12213'
article_processing_charge: No
author:
- first_name: Sadashige
full_name: Ishida, Sadashige
id: 6F7C4B96-A8E9-11E9-A7CA-09ECE5697425
last_name: Ishida
- first_name: Hugo
full_name: Lavenant, Hugo
last_name: Lavenant
citation:
ama: Ishida S, Lavenant H. Quantitative convergence of a discretization of dynamic
optimal transport using the dual formulation. arXiv. doi:10.48550/arXiv.2312.12213
apa: Ishida, S., & Lavenant, H. (n.d.). Quantitative convergence of a discretization
of dynamic optimal transport using the dual formulation. arXiv. https://doi.org/10.48550/arXiv.2312.12213
chicago: Ishida, Sadashige, and Hugo Lavenant. “Quantitative Convergence of a Discretization
of Dynamic Optimal Transport Using the Dual Formulation.” ArXiv, n.d. https://doi.org/10.48550/arXiv.2312.12213.
ieee: S. Ishida and H. Lavenant, “Quantitative convergence of a discretization of
dynamic optimal transport using the dual formulation,” arXiv. .
ista: Ishida S, Lavenant H. Quantitative convergence of a discretization of dynamic
optimal transport using the dual formulation. arXiv, 2312.12213.
mla: Ishida, Sadashige, and Hugo Lavenant. “Quantitative Convergence of a Discretization
of Dynamic Optimal Transport Using the Dual Formulation.” ArXiv, 2312.12213,
doi:10.48550/arXiv.2312.12213.
short: S. Ishida, H. Lavenant, ArXiv (n.d.).
date_created: 2023-12-21T10:14:37Z
date_published: 2023-12-19T00:00:00Z
date_updated: 2023-12-27T13:44:33Z
day: '19'
department:
- _id: GradSch
- _id: ChWo
doi: 10.48550/arXiv.2312.12213
external_id:
arxiv:
- '2312.12213'
keyword:
- Optimal transport
- Hamilton-Jacobi equation
- convex optimization
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2312.12213
month: '12'
oa: 1
oa_version: Preprint
project:
- _id: 34bc2376-11ca-11ed-8bc3-9a3b3961a088
grant_number: '101045083'
name: Computational Discovery of Numerical Algorithms for Animation and Simulation
of Natural Phenomena
publication: arXiv
publication_status: submitted
status: public
title: Quantitative convergence of a discretization of dynamic optimal transport using
the dual formulation
type: preprint
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '14735'
abstract:
- lang: eng
text: "Scaling blockchain protocols to perform on par with the expected needs of
Web3.0 has been proven to be a challenging task with almost a decade of research.
In the forefront of the current solution is the idea of separating the execution
of the updates encoded in a block from the ordering of blocks. In order to achieve
this, a new class of protocols called rollups has emerged. Rollups have as input
a total ordering of valid and invalid transactions and as output a new valid state-transition.\r\nIf
we study rollups from a distributed computing perspective, we uncover that rollups
take as input the output of a Byzantine Atomic Broadcast (BAB) protocol and convert
it to a State Machine Replication (SMR) protocol. BAB and SMR, however, are considered
equivalent as far as distributed computing is concerned and a solution to one
can easily be retrofitted to solve the other simply by adding/removing an execution
step before the validation of the input.\r\nThis “easy” step of retrofitting an
atomic broadcast solution to implement an SMR has, however, been overlooked in
practice. In this paper, we formalize the problem and show that after BAB is solved,
traditional impossibility results for consensus no longer apply towards an SMR.
Leveraging this we propose a distributed execution protocol that allows reduced
execution and storage cost per executor (O(log2n/n)) without relaxing the network
assumptions of the underlying BAB protocol and providing censorship-resistance.
Finally, we propose efficient non-interactive light client constructions that
leverage our efficient execution protocols and do not require any synchrony assumptions
or expensive ZK-proofs."
acknowledgement: 'Eleftherios Kokoris-Kogias is partially supported by Austrian Science
Fund (FWF) grant No: F8512-N.'
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Christos
full_name: Stefo, Christos
id: a20e8902-32b0-11ee-9fa8-b23fa638b793
last_name: Stefo
- first_name: Zhuolun
full_name: Xiang, Zhuolun
last_name: Xiang
- first_name: Eleftherios
full_name: Kokoris Kogias, Eleftherios
id: f5983044-d7ef-11ea-ac6d-fd1430a26d30
last_name: Kokoris Kogias
citation:
ama: 'Stefo C, Xiang Z, Kokoris Kogias E. Executing and proving over dirty ledgers.
In: 27th International Conference on Financial Cryptography and Data Security.
Vol 13950. Springer Nature; 2023:3-20. doi:10.1007/978-3-031-47754-6_1'
apa: 'Stefo, C., Xiang, Z., & Kokoris Kogias, E. (2023). Executing and proving
over dirty ledgers. In 27th International Conference on Financial Cryptography
and Data Security (Vol. 13950, pp. 3–20). Bol, Brac, Croatia: Springer Nature.
https://doi.org/10.1007/978-3-031-47754-6_1'
chicago: Stefo, Christos, Zhuolun Xiang, and Eleftherios Kokoris Kogias. “Executing
and Proving over Dirty Ledgers.” In 27th International Conference on Financial
Cryptography and Data Security, 13950:3–20. Springer Nature, 2023. https://doi.org/10.1007/978-3-031-47754-6_1.
ieee: C. Stefo, Z. Xiang, and E. Kokoris Kogias, “Executing and proving over dirty
ledgers,” in 27th International Conference on Financial Cryptography and Data
Security, Bol, Brac, Croatia, 2023, vol. 13950, pp. 3–20.
ista: 'Stefo C, Xiang Z, Kokoris Kogias E. 2023. Executing and proving over dirty
ledgers. 27th International Conference on Financial Cryptography and Data Security.
FC: Financial Cryptography and Data Security, LNCS, vol. 13950, 3–20.'
mla: Stefo, Christos, et al. “Executing and Proving over Dirty Ledgers.” 27th
International Conference on Financial Cryptography and Data Security, vol.
13950, Springer Nature, 2023, pp. 3–20, doi:10.1007/978-3-031-47754-6_1.
short: C. Stefo, Z. Xiang, E. Kokoris Kogias, in:, 27th International Conference
on Financial Cryptography and Data Security, Springer Nature, 2023, pp. 3–20.
conference:
end_date: 2023-05-05
location: Bol, Brac, Croatia
name: 'FC: Financial Cryptography and Data Security'
start_date: 2023-05-01
date_created: 2024-01-08T09:17:38Z
date_published: 2023-12-01T00:00:00Z
date_updated: 2024-01-08T09:28:14Z
day: '01'
department:
- _id: ElKo
- _id: GradSch
doi: 10.1007/978-3-031-47754-6_1
intvolume: ' 13950'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2022/1554
month: '12'
oa: 1
oa_version: Preprint
page: 3-20
project:
- _id: 34a4ce89-11ca-11ed-8bc3-8cc37fb6e11f
grant_number: F8512
name: Secure Network and Hardware for Efficient Blockchains
publication: 27th International Conference on Financial Cryptography and Data Security
publication_identifier:
eisbn:
- '9783031477546'
eissn:
- 0302-9743
isbn:
- '9783031477539'
issn:
- 1611-3349
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Executing and proving over dirty ledgers
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13950
year: '2023'
...
---
_id: '14539'
abstract:
- lang: eng
text: "Stochastic systems provide a formal framework for modelling and quantifying
uncertainty in systems and have been widely adopted in many application domains.
Formal\r\nverification and control of finite state stochastic systems, a subfield
of formal methods\r\nalso known as probabilistic model checking, is well studied.
In contrast, formal verification and control of infinite state stochastic systems
have received comparatively\r\nless attention. However, infinite state stochastic
systems commonly arise in practice.\r\nFor instance, probabilistic models that
contain continuous probability distributions such\r\nas normal or uniform, or
stochastic dynamical systems which are a classical model for\r\ncontrol under
uncertainty, both give rise to infinite state systems.\r\nThe goal of this thesis
is to contribute to laying theoretical and algorithmic foundations\r\nof fully
automated formal verification and control of infinite state stochastic systems,\r\nwith
a particular focus on systems that may be executed over a long or infinite time.\r\nWe
consider formal verification of infinite state stochastic systems in the setting
of\r\nstatic analysis of probabilistic programs and formal control in the setting
of controller\r\nsynthesis in stochastic dynamical systems. For both problems,
we present some of the\r\nfirst fully automated methods for probabilistic (a.k.a.
quantitative) reachability and\r\nsafety analysis applicable to infinite time
horizon systems. We also advance the state\r\nof the art of probability 1 (a.k.a.
qualitative) reachability analysis for both problems.\r\nFinally, for formal controller
synthesis in stochastic dynamical systems, we present a\r\nnovel framework for
learning neural network control policies in stochastic dynamical\r\nsystems with
formal guarantees on correctness with respect to quantitative reachability,\r\nsafety
or reach-avoid specifications.\r\n"
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Dorde
full_name: Zikelic, Dorde
id: 294AA7A6-F248-11E8-B48F-1D18A9856A87
last_name: Zikelic
orcid: 0000-0002-4681-1699
citation:
ama: Zikelic D. Automated verification and control of infinite state stochastic
systems. 2023. doi:10.15479/14539
apa: Zikelic, D. (2023). Automated verification and control of infinite state
stochastic systems. Institute of Science and Technology Austria. https://doi.org/10.15479/14539
chicago: Zikelic, Dorde. “Automated Verification and Control of Infinite State Stochastic
Systems.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/14539.
ieee: D. Zikelic, “Automated verification and control of infinite state stochastic
systems,” Institute of Science and Technology Austria, 2023.
ista: Zikelic D. 2023. Automated verification and control of infinite state stochastic
systems. Institute of Science and Technology Austria.
mla: Zikelic, Dorde. Automated Verification and Control of Infinite State Stochastic
Systems. Institute of Science and Technology Austria, 2023, doi:10.15479/14539.
short: D. Zikelic, Automated Verification and Control of Infinite State Stochastic
Systems, Institute of Science and Technology Austria, 2023.
date_created: 2023-11-15T13:39:10Z
date_published: 2023-11-15T00:00:00Z
date_updated: 2024-01-16T11:58:15Z
day: '15'
ddc:
- '000'
degree_awarded: PhD
department:
- _id: KrCh
- _id: GradSch
doi: 10.15479/14539
ec_funded: 1
file:
- access_level: open_access
checksum: f23e002b0059ca78e1fbb864da52dd7e
content_type: application/pdf
creator: cchlebak
date_created: 2023-11-15T13:43:28Z
date_updated: 2023-11-15T13:43:28Z
file_id: '14540'
file_name: main.pdf
file_size: 2116426
relation: main_file
success: 1
- access_level: closed
checksum: 80ca37618a3c7b59866875f8be9b15ed
content_type: application/x-zip-compressed
creator: cchlebak
date_created: 2023-11-15T13:44:24Z
date_updated: 2023-11-15T13:44:24Z
file_id: '14541'
file_name: thesis_source.zip
file_size: 35884057
relation: source_file
file_date_updated: 2023-11-15T13:44:24Z
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: '256'
project:
- _id: 0599E47C-7A3F-11EA-A408-12923DDC885E
call_identifier: H2020
grant_number: '863818'
name: 'Formal Methods for Stochastic Models: Algorithms and Applications'
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
isbn:
- 978-3-99078-036-7
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '1194'
relation: part_of_dissertation
status: public
- id: '12000'
relation: part_of_dissertation
status: public
- id: '9644'
relation: part_of_dissertation
status: public
- id: '12511'
relation: part_of_dissertation
status: public
- id: '14600'
relation: part_of_dissertation
status: public
- id: '14601'
relation: part_of_dissertation
status: public
- id: '10414'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
title: Automated verification and control of infinite state stochastic systems
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14863'
article_number: EGU23-6157
article_processing_charge: No
author:
- first_name: Andrea
full_name: Polesello, Andrea
id: 74c777f4-32da-11ee-b498-874db0835561
last_name: Polesello
- first_name: Caroline J
full_name: Muller, Caroline J
id: f978ccb0-3f7f-11eb-b193-b0e2bd13182b
last_name: Muller
orcid: 0000-0001-5836-5350
- first_name: Claudia
full_name: Pasquero, Claudia
last_name: Pasquero
- first_name: Agostino N.
full_name: Meroni, Agostino N.
last_name: Meroni
citation:
ama: 'Polesello A, Muller CJ, Pasquero C, Meroni AN. Intensification mechanisms
of tropical cyclones. In: EGU General Assembly 2023. European Geosciences
Union; 2023. doi:10.5194/egusphere-egu23-6157'
apa: 'Polesello, A., Muller, C. J., Pasquero, C., & Meroni, A. N. (2023). Intensification
mechanisms of tropical cyclones. In EGU General Assembly 2023. Vienna,
Austria & Virtual: European Geosciences Union. https://doi.org/10.5194/egusphere-egu23-6157'
chicago: Polesello, Andrea, Caroline J Muller, Claudia Pasquero, and Agostino N.
Meroni. “Intensification Mechanisms of Tropical Cyclones.” In EGU General Assembly
2023. European Geosciences Union, 2023. https://doi.org/10.5194/egusphere-egu23-6157.
ieee: A. Polesello, C. J. Muller, C. Pasquero, and A. N. Meroni, “Intensification
mechanisms of tropical cyclones,” in EGU General Assembly 2023, Vienna,
Austria & Virtual, 2023.
ista: Polesello A, Muller CJ, Pasquero C, Meroni AN. 2023. Intensification mechanisms
of tropical cyclones. EGU General Assembly 2023. EGU General Assembly, EGU23-6157.
mla: Polesello, Andrea, et al. “Intensification Mechanisms of Tropical Cyclones.”
EGU General Assembly 2023, EGU23-6157, European Geosciences Union, 2023,
doi:10.5194/egusphere-egu23-6157.
short: A. Polesello, C.J. Muller, C. Pasquero, A.N. Meroni, in:, EGU General Assembly
2023, European Geosciences Union, 2023.
conference:
end_date: 2023-04-28
location: Vienna, Austria & Virtual
name: EGU General Assembly
start_date: 2023-04-23
date_created: 2024-01-22T12:08:12Z
date_published: 2023-04-13T00:00:00Z
date_updated: 2024-01-24T11:25:07Z
day: '13'
ddc:
- '550'
department:
- _id: CaMu
- _id: GradSch
doi: 10.5194/egusphere-egu23-6157
file:
- access_level: open_access
checksum: 8cb88c1bc80ccee328478a62064d98f7
content_type: application/pdf
creator: dernst
date_created: 2024-01-24T11:19:54Z
date_updated: 2024-01-24T11:19:54Z
file_id: '14883'
file_name: 2023_EGU_Polesello.pdf
file_size: 296769
relation: main_file
success: 1
file_date_updated: 2024-01-24T11:19:54Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
publication: EGU General Assembly 2023
publication_status: published
publisher: European Geosciences Union
status: public
title: Intensification mechanisms of tropical cyclones
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference_abstract
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '13049'
abstract:
- lang: eng
text: "We propose a computational design approach for covering a surface with individually
addressable RGB LEDs, effectively forming a low-resolution surface screen. To
achieve a low-cost and scalable approach, we propose creating designs from flat
PCB panels bent in-place along the surface of a 3D printed core. Working with
standard rigid PCBs enables the use of\r\nestablished PCB manufacturing services,
allowing the fabrication of designs with several hundred LEDs. \r\nOur approach
optimizes the PCB geometry for folding, and then jointly optimizes the LED packing,
circuit and routing, solving a challenging layout problem under strict manufacturing
requirements. Unlike paper, PCBs cannot bend beyond a certain point without breaking.
Therefore, we introduce parametric cut patterns acting as hinges, designed to
allow bending while remaining compact. To tackle the joint optimization of placement,
circuit and routing, we propose a specialized algorithm that splits the global
problem into one sub-problem per triangle, which is then individually solved.\r\nOur
technique generates PCB blueprints in a completely automated way. After being
fabricated by a PCB manufacturing service, the boards are bent and glued by the
user onto the 3D printed support. We demonstrate our technique on a range of physical
models and virtual examples, creating intricate surface light patterns from hundreds
of LEDs."
acknowledged_ssus:
- _id: M-Shop
acknowledgement: We thank the reviewers for the valuable feedback. We also thank the
Miba Machine Shop at ISTA, PCBWay, and PragoBoard for helping us with fabrication
and assembly. This project was supported by the European Research Council (ERC)
under the European Union’s Horizon 2020 research and innovation program (Grant Agreement
No. 715767 – MATERIALIZABLE).
article_number: '142'
article_processing_charge: No
article_type: original
author:
- first_name: Marco
full_name: Freire, Marco
last_name: Freire
- first_name: Manas
full_name: Bhargava, Manas
id: FF8FA64C-AA6A-11E9-99AD-50D4E5697425
last_name: Bhargava
orcid: 0009-0007-6138-6890
- first_name: Camille
full_name: Schreck, Camille
id: 2B14B676-F248-11E8-B48F-1D18A9856A87
last_name: Schreck
- first_name: Pierre-Alexandre
full_name: Hugron, Pierre-Alexandre
last_name: Hugron
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
- first_name: Sylvain
full_name: Lefebvre, Sylvain
last_name: Lefebvre
citation:
ama: 'Freire M, Bhargava M, Schreck C, Hugron P-A, Bickel B, Lefebvre S. PCBend:
Light up your 3D shapes with foldable circuit boards. Transactions on Graphics.
2023;42(4). doi:10.1145/3592411'
apa: 'Freire, M., Bhargava, M., Schreck, C., Hugron, P.-A., Bickel, B., & Lefebvre,
S. (2023). PCBend: Light up your 3D shapes with foldable circuit boards. Transactions
on Graphics. Los Angeles, CA, United States: Association for Computing Machinery.
https://doi.org/10.1145/3592411'
chicago: 'Freire, Marco, Manas Bhargava, Camille Schreck, Pierre-Alexandre Hugron,
Bernd Bickel, and Sylvain Lefebvre. “PCBend: Light up Your 3D Shapes with Foldable
Circuit Boards.” Transactions on Graphics. Association for Computing Machinery,
2023. https://doi.org/10.1145/3592411.'
ieee: 'M. Freire, M. Bhargava, C. Schreck, P.-A. Hugron, B. Bickel, and S. Lefebvre,
“PCBend: Light up your 3D shapes with foldable circuit boards,” Transactions
on Graphics, vol. 42, no. 4. Association for Computing Machinery, 2023.'
ista: 'Freire M, Bhargava M, Schreck C, Hugron P-A, Bickel B, Lefebvre S. 2023.
PCBend: Light up your 3D shapes with foldable circuit boards. Transactions on
Graphics. 42(4), 142.'
mla: 'Freire, Marco, et al. “PCBend: Light up Your 3D Shapes with Foldable Circuit
Boards.” Transactions on Graphics, vol. 42, no. 4, 142, Association for
Computing Machinery, 2023, doi:10.1145/3592411.'
short: M. Freire, M. Bhargava, C. Schreck, P.-A. Hugron, B. Bickel, S. Lefebvre,
Transactions on Graphics 42 (2023).
conference:
end_date: 2023-08-10
location: Los Angeles, CA, United States
name: 'SIGGRAPH: Computer Graphics and Interactive Techniques Conference'
start_date: 2023-08-06
date_created: 2023-05-22T08:37:04Z
date_published: 2023-07-26T00:00:00Z
date_updated: 2024-01-29T10:30:49Z
day: '26'
ddc:
- '006'
department:
- _id: GradSch
- _id: BeBi
doi: 10.1145/3592411
ec_funded: 1
external_id:
isi:
- '001044671300108'
file:
- access_level: open_access
checksum: a0b0ba3b36f43a94388e8824613d812a
content_type: application/pdf
creator: dernst
date_created: 2023-06-19T11:02:23Z
date_updated: 2023-06-19T11:02:23Z
file_id: '13156'
file_name: 2023_ACMToG_Freire.pdf
file_size: 78940724
relation: main_file
success: 1
- access_level: open_access
checksum: b9206bbb67af82df49b7e7cdbde3410c
content_type: application/pdf
creator: dernst
date_created: 2023-06-20T12:20:51Z
date_updated: 2023-06-20T12:20:51Z
file_id: '13157'
file_name: 2023_ACMToG_SuppMaterial_Freire.pdf
file_size: 34345905
relation: main_file
success: 1
file_date_updated: 2023-06-20T12:20:51Z
has_accepted_license: '1'
intvolume: ' 42'
isi: 1
issue: '4'
keyword:
- PCB design and layout
- Mesh geometry models
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
project:
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publication: Transactions on Graphics
publication_identifier:
eissn:
- 1557-7368
issn:
- 0730-0301
publication_status: published
publisher: Association for Computing Machinery
quality_controlled: '1'
status: public
title: 'PCBend: Light up your 3D shapes with foldable circuit boards'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 42
year: '2023'
...
---
_id: '14032'
abstract:
- lang: eng
text: Arrays of Josephson junctions are governed by a competition between superconductivity
and repulsive Coulomb interactions, and are expected to exhibit diverging low-temperature
resistance when interactions exceed a critical level. Here we report a study of
the transport and microwave response of Josephson arrays with interactions exceeding
this level. Contrary to expectations, we observe that the array resistance drops
dramatically as the temperature is decreased—reminiscent of superconducting behaviour—and
then saturates at low temperature. Applying a magnetic field, we eventually observe
a transition to a highly resistive regime. These observations can be understood
within a theoretical picture that accounts for the effect of thermal fluctuations
on the insulating phase. On the basis of the agreement between experiment and
theory, we suggest that apparent superconductivity in our Josephson arrays arises
from melting the zero-temperature insulator.
acknowledged_ssus:
- _id: M-Shop
- _id: NanoFab
acknowledgement: We thank D. Haviland, J. Pekola, C. Ciuti, A. Bubis and A. Shnirman
for helpful feedback on the paper. This research was supported by the Scientific
Service Units of IST Austria through resources provided by the MIBA Machine Shop
and the Nanofabrication Facility. Work supported by the Austrian FWF grant P33692-N
(S.M., J.S. and A.P.H.), the European Union’s Horizon 2020 Research and Innovation
programme under the Marie Skłodowska-Curie Grant Agreement No. 754411 (J.S.) and
a NOMIS foundation research grant (J.M.F. and A.P.H.).
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Soham
full_name: Mukhopadhyay, Soham
id: FDE60288-A89D-11E9-947F-1AF6E5697425
last_name: Mukhopadhyay
- first_name: Jorden L
full_name: Senior, Jorden L
id: 5479D234-2D30-11EA-89CC-40953DDC885E
last_name: Senior
orcid: 0000-0002-0672-9295
- first_name: Jaime
full_name: Saez Mollejo, Jaime
id: e0390f72-f6e0-11ea-865d-862393336714
last_name: Saez Mollejo
- first_name: Denise
full_name: Puglia, Denise
id: 4D495994-AE37-11E9-AC72-31CAE5697425
last_name: Puglia
orcid: 0000-0003-1144-2763
- first_name: Martin
full_name: Zemlicka, Martin
id: 2DCF8DE6-F248-11E8-B48F-1D18A9856A87
last_name: Zemlicka
- first_name: Johannes M
full_name: Fink, Johannes M
id: 4B591CBA-F248-11E8-B48F-1D18A9856A87
last_name: Fink
orcid: 0000-0001-8112-028X
- first_name: Andrew P
full_name: Higginbotham, Andrew P
id: 4AD6785A-F248-11E8-B48F-1D18A9856A87
last_name: Higginbotham
orcid: 0000-0003-2607-2363
citation:
ama: Mukhopadhyay S, Senior JL, Saez Mollejo J, et al. Superconductivity from a
melted insulator in Josephson junction arrays. Nature Physics. 2023;19:1630-1635.
doi:10.1038/s41567-023-02161-w
apa: Mukhopadhyay, S., Senior, J. L., Saez Mollejo, J., Puglia, D., Zemlicka, M.,
Fink, J. M., & Higginbotham, A. P. (2023). Superconductivity from a melted
insulator in Josephson junction arrays. Nature Physics. Springer Nature.
https://doi.org/10.1038/s41567-023-02161-w
chicago: Mukhopadhyay, Soham, Jorden L Senior, Jaime Saez Mollejo, Denise Puglia,
Martin Zemlicka, Johannes M Fink, and Andrew P Higginbotham. “Superconductivity
from a Melted Insulator in Josephson Junction Arrays.” Nature Physics.
Springer Nature, 2023. https://doi.org/10.1038/s41567-023-02161-w.
ieee: S. Mukhopadhyay et al., “Superconductivity from a melted insulator
in Josephson junction arrays,” Nature Physics, vol. 19. Springer Nature,
pp. 1630–1635, 2023.
ista: Mukhopadhyay S, Senior JL, Saez Mollejo J, Puglia D, Zemlicka M, Fink JM,
Higginbotham AP. 2023. Superconductivity from a melted insulator in Josephson
junction arrays. Nature Physics. 19, 1630–1635.
mla: Mukhopadhyay, Soham, et al. “Superconductivity from a Melted Insulator in Josephson
Junction Arrays.” Nature Physics, vol. 19, Springer Nature, 2023, pp. 1630–35,
doi:10.1038/s41567-023-02161-w.
short: S. Mukhopadhyay, J.L. Senior, J. Saez Mollejo, D. Puglia, M. Zemlicka, J.M.
Fink, A.P. Higginbotham, Nature Physics 19 (2023) 1630–1635.
date_created: 2023-08-11T07:41:17Z
date_published: 2023-11-01T00:00:00Z
date_updated: 2024-01-29T11:27:49Z
day: '01'
ddc:
- '530'
department:
- _id: GradSch
- _id: AnHi
- _id: JoFi
doi: 10.1038/s41567-023-02161-w
ec_funded: 1
external_id:
isi:
- '001054563800006'
file:
- access_level: open_access
checksum: 1fc86d71bfbf836e221c1e925343adc5
content_type: application/pdf
creator: dernst
date_created: 2024-01-29T11:25:38Z
date_updated: 2024-01-29T11:25:38Z
file_id: '14899'
file_name: 2023_NaturePhysics_Mukhopadhyay.pdf
file_size: 1977706
relation: main_file
success: 1
file_date_updated: 2024-01-29T11:25:38Z
has_accepted_license: '1'
intvolume: ' 19'
isi: 1
keyword:
- General Physics and Astronomy
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 1630-1635
project:
- _id: 0aa3608a-070f-11eb-9043-e9cd8a2bd931
grant_number: P33692
name: Cavity electromechanics across a quantum phase transition
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: eb9b30ac-77a9-11ec-83b8-871f581d53d2
name: Protected states of quantum matter
- _id: bd5b4ec5-d553-11ed-ba76-a6eedb083344
name: Protected states of quantum matter
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Superconductivity from a melted insulator in Josephson junction arrays
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2023'
...
---
_id: '13128'
abstract:
- lang: eng
text: "Given A⊆GL2(Fq), we prove that there exist disjoint subsets B,C⊆A such
that A=B⊔C and their additive and multiplicative energies satisfying max{E+(B),E×(C)}≪|A|3/M(|A|),
where\r\nM(|A|)=min{q4/3/|A|1/3(log|A|)2/3,|A|4/5/q13/5(log|A|)27/10}.\r\n We
also study some related questions on moderate expanders over matrix rings, namely,
for A,B,C⊆GL2(Fq), we have |AB+C|, |(A+B)C|≫q4, whenever |A||B||C|≫q10+1/2.
These improve earlier results due to Karabulut, Koh, Pham, Shen, and Vinh ([2019],
Expanding phenomena over matrix rings, ForumMath., 31, 951–970).\r\n"
article_processing_charge: No
article_type: original
author:
- first_name: Ali
full_name: Mohammadi, Ali
last_name: Mohammadi
- first_name: Thang
full_name: Pham, Thang
last_name: Pham
- first_name: Yiting
full_name: Wang, Yiting
id: 1917d194-076e-11ed-97cd-837255f88785
last_name: Wang
orcid: 0000-0002-2856-767X
citation:
ama: Mohammadi A, Pham T, Wang Y. An energy decomposition theorem for matrices and
related questions. Canadian Mathematical Bulletin. 2023;66(4):1280-1295.
doi:10.4153/S000843952300036X
apa: Mohammadi, A., Pham, T., & Wang, Y. (2023). An energy decomposition theorem
for matrices and related questions. Canadian Mathematical Bulletin. Cambridge
University Press. https://doi.org/10.4153/S000843952300036X
chicago: Mohammadi, Ali, Thang Pham, and Yiting Wang. “An Energy Decomposition Theorem
for Matrices and Related Questions.” Canadian Mathematical Bulletin. Cambridge
University Press, 2023. https://doi.org/10.4153/S000843952300036X.
ieee: A. Mohammadi, T. Pham, and Y. Wang, “An energy decomposition theorem for matrices
and related questions,” Canadian Mathematical Bulletin, vol. 66, no. 4.
Cambridge University Press, pp. 1280–1295, 2023.
ista: Mohammadi A, Pham T, Wang Y. 2023. An energy decomposition theorem for matrices
and related questions. Canadian Mathematical Bulletin. 66(4), 1280–1295.
mla: Mohammadi, Ali, et al. “An Energy Decomposition Theorem for Matrices and Related
Questions.” Canadian Mathematical Bulletin, vol. 66, no. 4, Cambridge University
Press, 2023, pp. 1280–95, doi:10.4153/S000843952300036X.
short: A. Mohammadi, T. Pham, Y. Wang, Canadian Mathematical Bulletin 66 (2023)
1280–1295.
date_created: 2023-06-11T22:00:40Z
date_published: 2023-12-01T00:00:00Z
date_updated: 2024-01-29T11:00:46Z
day: '01'
department:
- _id: GradSch
doi: 10.4153/S000843952300036X
external_id:
arxiv:
- '2106.07328'
isi:
- '001011963000001'
intvolume: ' 66'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2106.07328
month: '12'
oa: 1
oa_version: Preprint
page: 1280-1295
publication: Canadian Mathematical Bulletin
publication_identifier:
eissn:
- 1496-4287
issn:
- 0008-4395
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: An energy decomposition theorem for matrices and related questions
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 66
year: '2023'
...
---
_id: '14087'
abstract:
- lang: eng
text: Polar active matter of self-propelled particles sustain spontaneous flows
through the full-integer topological defects. We study theoretically the incompressible
flow profiles around ±1 defects induced by polar and dipolar active forces. We
show that dipolar forces induce vortical flows around the +1 defect, while the
flow around the −1 defect has an 8-fold rotational symmetry. The vortical flow
changes its chirality near the +1 defect core in the absence of the friction with
a substrate. We show analytically that the flow induced by polar active forces
is vortical near the +1 defect and is 4-fold symmetric near the −1 defect, while
it becomes uniform in the far-field. For a pair of oppositely charged defects,
this polar flow contributes to a mutual interaction force that depends only on
the orientation of the defect pair relative to the background polarization, and
that enhances defect pair annihilation. This is in contradiction with the effect
of dipolar active forces which decay inversely proportional with the defect separation
distance. As such, our analyses reveals a long-ranged mechanism for the pairwise
interaction between topological defects in polar active matter.
acknowledgement: J. Rø and L. A. acknowledge support from the Research Council of
Norway through the Center of Excellence funding scheme, Project No. 262644 (PoreLab).
A. D. acknowledges funding from the Novo Nordisk Foundation (grant No. NNF18SA0035142
and NERD grant No. NNF21OC0068687), Villum Fonden Grant no. 29476, and the European
Union via the ERC-Starting Grant PhysCoMeT. Views and opinions expressed are however
those of the authors only and do not necessarily reflect those of the European Union
or the European Research Council. Neither the European Union nor the granting authority
can be held responsible for them.
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Jonas
full_name: Rønning, Jonas
last_name: Rønning
- first_name: Julian B
full_name: Renaud, Julian B
id: 7af6767d-14eb-11ed-b536-a32449ae867c
last_name: Renaud
- first_name: Amin
full_name: Doostmohammadi, Amin
last_name: Doostmohammadi
- first_name: Luiza
full_name: Angheluta, Luiza
last_name: Angheluta
citation:
ama: Rønning J, Renaud JB, Doostmohammadi A, Angheluta L. Spontaneous flows and
dynamics of full-integer topological defects in polar active matter. Soft Matter.
2023;39:7513-7527. doi:10.1039/d3sm00316g
apa: Rønning, J., Renaud, J. B., Doostmohammadi, A., & Angheluta, L. (2023).
Spontaneous flows and dynamics of full-integer topological defects in polar active
matter. Soft Matter. Royal Society of Chemistry. https://doi.org/10.1039/d3sm00316g
chicago: Rønning, Jonas, Julian B Renaud, Amin Doostmohammadi, and Luiza Angheluta.
“Spontaneous Flows and Dynamics of Full-Integer Topological Defects in Polar Active
Matter.” Soft Matter. Royal Society of Chemistry, 2023. https://doi.org/10.1039/d3sm00316g.
ieee: J. Rønning, J. B. Renaud, A. Doostmohammadi, and L. Angheluta, “Spontaneous
flows and dynamics of full-integer topological defects in polar active matter,”
Soft Matter, vol. 39. Royal Society of Chemistry, pp. 7513–7527, 2023.
ista: Rønning J, Renaud JB, Doostmohammadi A, Angheluta L. 2023. Spontaneous flows
and dynamics of full-integer topological defects in polar active matter. Soft
Matter. 39, 7513–7527.
mla: Rønning, Jonas, et al. “Spontaneous Flows and Dynamics of Full-Integer Topological
Defects in Polar Active Matter.” Soft Matter, vol. 39, Royal Society of
Chemistry, 2023, pp. 7513–27, doi:10.1039/d3sm00316g.
short: J. Rønning, J.B. Renaud, A. Doostmohammadi, L. Angheluta, Soft Matter 39
(2023) 7513–7527.
date_created: 2023-08-20T22:01:15Z
date_published: 2023-09-01T00:00:00Z
date_updated: 2024-01-30T12:49:24Z
day: '01'
ddc:
- '540'
department:
- _id: GradSch
doi: 10.1039/d3sm00316g
external_id:
arxiv:
- '2303.07063'
isi:
- '001035766100001'
file:
- access_level: open_access
checksum: b936747170d0b708172b518078c4081a
content_type: application/pdf
creator: dernst
date_created: 2024-01-30T12:48:24Z
date_updated: 2024-01-30T12:48:24Z
file_id: '14908'
file_name: 2023_SoftMatter_Ronning.pdf
file_size: 7660662
relation: main_file
success: 1
file_date_updated: 2024-01-30T12:48:24Z
has_accepted_license: '1'
intvolume: ' 39'
isi: 1
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 7513-7527
publication: Soft Matter
publication_identifier:
eissn:
- 1744-6848
issn:
- 1744-683X
publication_status: published
publisher: Royal Society of Chemistry
quality_controlled: '1'
scopus_import: '1'
status: public
title: Spontaneous flows and dynamics of full-integer topological defects in polar
active matter
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 39
year: '2023'
...
---
_id: '12859'
abstract:
- lang: eng
text: 'Machine learning models are vulnerable to adversarial perturbations, and
a thought-provoking paper by Bubeck and Sellke has analyzed this phenomenon through
the lens of over-parameterization: interpolating smoothly the data requires significantly
more parameters than simply memorizing it. However, this "universal" law provides
only a necessary condition for robustness, and it is unable to discriminate between
models. In this paper, we address these gaps by focusing on empirical risk minimization
in two prototypical settings, namely, random features and the neural tangent kernel
(NTK). We prove that, for random features, the model is not robust for any degree
of over-parameterization, even when the necessary condition coming from the universal
law of robustness is satisfied. In contrast, for even activations, the NTK model
meets the universal lower bound, and it is robust as soon as the necessary condition
on over-parameterization is fulfilled. This also addresses a conjecture in prior
work by Bubeck, Li and Nagaraj. Our analysis decouples the effect of the kernel
of the model from an "interaction matrix", which describes the interaction with
the test data and captures the effect of the activation. Our theoretical results
are corroborated by numerical evidence on both synthetic and standard datasets
(MNIST, CIFAR-10).'
acknowledgement: "Simone Bombari and Marco Mondelli were partially supported by the
2019 Lopez-Loreta prize, and\r\nthe authors would like to thank Hamed Hassani for
helpful discussions.\r\n"
alternative_title:
- PMLR
article_processing_charge: No
author:
- first_name: Simone
full_name: Bombari, Simone
id: ca726dda-de17-11ea-bc14-f9da834f63aa
last_name: Bombari
- first_name: Shayan
full_name: Kiyani, Shayan
id: f5a2b424-e339-11ed-8435-ff3b4fe70cf8
last_name: Kiyani
- first_name: Marco
full_name: Mondelli, Marco
id: 27EB676C-8706-11E9-9510-7717E6697425
last_name: Mondelli
orcid: 0000-0002-3242-7020
citation:
ama: 'Bombari S, Kiyani S, Mondelli M. Beyond the universal law of robustness: Sharper
laws for random features and neural tangent kernels. In: Proceedings of the
40th International Conference on Machine Learning. Vol 202. ML Research Press;
2023:2738-2776.'
apa: 'Bombari, S., Kiyani, S., & Mondelli, M. (2023). Beyond the universal law
of robustness: Sharper laws for random features and neural tangent kernels. In
Proceedings of the 40th International Conference on Machine Learning (Vol.
202, pp. 2738–2776). Honolulu, HI, United States: ML Research Press.'
chicago: 'Bombari, Simone, Shayan Kiyani, and Marco Mondelli. “Beyond the Universal
Law of Robustness: Sharper Laws for Random Features and Neural Tangent Kernels.”
In Proceedings of the 40th International Conference on Machine Learning,
202:2738–76. ML Research Press, 2023.'
ieee: 'S. Bombari, S. Kiyani, and M. Mondelli, “Beyond the universal law of robustness:
Sharper laws for random features and neural tangent kernels,” in Proceedings
of the 40th International Conference on Machine Learning, Honolulu, HI, United
States, 2023, vol. 202, pp. 2738–2776.'
ista: 'Bombari S, Kiyani S, Mondelli M. 2023. Beyond the universal law of robustness:
Sharper laws for random features and neural tangent kernels. Proceedings of the
40th International Conference on Machine Learning. ICML: International Conference
on Machine Learning, PMLR, vol. 202, 2738–2776.'
mla: 'Bombari, Simone, et al. “Beyond the Universal Law of Robustness: Sharper Laws
for Random Features and Neural Tangent Kernels.” Proceedings of the 40th International
Conference on Machine Learning, vol. 202, ML Research Press, 2023, pp. 2738–76.'
short: S. Bombari, S. Kiyani, M. Mondelli, in:, Proceedings of the 40th International
Conference on Machine Learning, ML Research Press, 2023, pp. 2738–2776.
conference:
end_date: 2023-07-29
location: Honolulu, HI, United States
name: 'ICML: International Conference on Machine Learning'
start_date: 2023-07-23
date_created: 2023-04-23T16:11:03Z
date_published: 2023-10-27T00:00:00Z
date_updated: 2024-02-06T07:42:00Z
day: '27'
department:
- _id: GradSch
- _id: MaMo
external_id:
arxiv:
- '2302.01629'
intvolume: ' 202'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/2302.01629
month: '10'
oa: 1
oa_version: Preprint
page: 2738-2776
project:
- _id: 059876FA-7A3F-11EA-A408-12923DDC885E
name: Prix Lopez-Loretta 2019 - Marco Mondelli
publication: Proceedings of the 40th International Conference on Machine Learning
publication_status: published
publisher: ML Research Press
quality_controlled: '1'
related_material:
link:
- relation: software
url: https://github.com/simone-bombari/beyond-universal-robustness
status: public
title: 'Beyond the universal law of robustness: Sharper laws for random features and
neural tangent kernels'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 202
year: '2023'
...
---
_id: '13107'
abstract:
- lang: eng
text: "Within the human body, the brain exhibits the highest rate of energy consumption
amongst all organs, with the majority of generated ATP being utilized to sustain
neuronal activity. Therefore, the metabolism of the mature cerebral cortex is
geared towards preserving metabolic homeostasis whilst generating significant
amounts of energy. This requires a precise interplay between diverse metabolic
pathways, spanning from a tissue-wide scale to the level of individual neurons.
Disturbances to this delicate metabolic equilibrium, such as those resulting from
maternal malnutrition\r\nor mutations affecting metabolic enzymes, often result
in neuropathological variants of neurodevelopment. For instance, mutations in
SLC7A5, a transporter of metabolically essential large neutral amino acids (LNAAs),
have been associated with autism and microcephaly. However, despite recent progress
in the field, the extent of metabolic restructuring that occurs within the developing
brain and the corresponding alterations in nutrient demands during various critical
periods remain largely unknown. To investigate this, we performed metabolomic
profiling of the murine cerebral cortex to characterize the metabolic state of
the forebrain at different developmental stages. We found that the developing
cortex undergoes substantial metabolic reprogramming, with specific sets of metabolites
displaying stage-specific changes. According to our observations, we determined
a distinct temporal period in postnatal development during which the cortex displays
heightened reliance on LNAAs. Hence, using a conditional knock-out mouse model,
we deleted Slc7a5 in neural cells, allowing us to monitor the impact of a perturbed
neuronal metabolic state across multiple developmental stages of corticogenesis.
We found that manipulating the levels of essential LNAAs in cortical neurons in
vivo affects one particular perinatal developmental period critical for cortical
network refinement. Abnormally low intracellular LNAA levels result in cell-autonomous
alterations in neuronal lipid metabolism, excitability, and survival during this
particular time window. Although most of the effects of Slc7a5 deletion on neuronal
physiology are transient, derailment of these processes during this brief but
crucial window leads to long-term circuit dysfunction in mice. In conclusion,
out data indicate that the cerebral cortex undergoes significant metabolic reorganization
during development. This process involves the intricate integration of multiple
metabolic pathways to ensure optimal neuronal function throughout different developmental
stages. Our findings offer a paradigm for understanding how neurons synchronize
the expression of nutrient-related genes with their activity to allow proper brain
maturation. Further, our results demonstrate that disruptions in these precisely
calibrated metabolic processes during critical periods of brain development may
result in neuropathological outcomes in mice and in humans."
acknowledged_ssus:
- _id: PreCl
- _id: Bio
- _id: EM-Fac
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Lisa
full_name: Knaus, Lisa
id: 3B2ABCF4-F248-11E8-B48F-1D18A9856A87
last_name: Knaus
citation:
ama: 'Knaus L. The metabolism of the developing brain : How large neutral amino
acids modulate perinatal neuronal excitability and survival. 2023. doi:10.15479/at:ista:13107'
apa: 'Knaus, L. (2023). The metabolism of the developing brain : How large neutral
amino acids modulate perinatal neuronal excitability and survival. Institute
of Science and Technology Austria. https://doi.org/10.15479/at:ista:13107'
chicago: 'Knaus, Lisa. “The Metabolism of the Developing Brain : How Large Neutral
Amino Acids Modulate Perinatal Neuronal Excitability and Survival.” Institute
of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:13107.'
ieee: 'L. Knaus, “The metabolism of the developing brain : How large neutral amino
acids modulate perinatal neuronal excitability and survival,” Institute of Science
and Technology Austria, 2023.'
ista: 'Knaus L. 2023. The metabolism of the developing brain : How large neutral
amino acids modulate perinatal neuronal excitability and survival. Institute of
Science and Technology Austria.'
mla: 'Knaus, Lisa. The Metabolism of the Developing Brain : How Large Neutral
Amino Acids Modulate Perinatal Neuronal Excitability and Survival. Institute
of Science and Technology Austria, 2023, doi:10.15479/at:ista:13107.'
short: 'L. Knaus, The Metabolism of the Developing Brain : How Large Neutral Amino
Acids Modulate Perinatal Neuronal Excitability and Survival, Institute of Science
and Technology Austria, 2023.'
date_created: 2023-06-01T09:05:24Z
date_published: 2023-05-31T00:00:00Z
date_updated: 2024-02-07T08:03:33Z
day: '31'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: GaNo
doi: 10.15479/at:ista:13107
ec_funded: 1
file:
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language:
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month: '05'
oa: 1
oa_version: Published Version
page: '147'
project:
- _id: 25444568-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715508'
name: Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo
and in vitro Models
- _id: 2548AE96-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '12802'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
title: 'The metabolism of the developing brain : How large neutral amino acids modulate
perinatal neuronal excitability and survival'
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14466'
abstract:
- lang: eng
text: The first long-lived turbulent structures observable in planar shear flows
take the form of localized stripes, inclined with respect to the mean flow direction.
The dynamics of these stripes is central to transition, and recent studies proposed
an analogy to directed percolation where the stripes’ proliferation is ultimately
responsible for the turbulence becoming sustained. In the present study we focus
on the internal stripe dynamics as well as on the eventual stripe expansion, and
we compare the underlying mechanisms in pressure- and shear-driven planar flows,
respectively, plane-Poiseuille and plane-Couette flow. Despite the similarities
of the overall laminar–turbulence patterns, the stripe proliferation processes
in the two cases are fundamentally different. Starting from the growth and sustenance
of individual stripes, we find that in plane-Couette flow new streaks are created
stochastically throughout the stripe whereas in plane-Poiseuille flow streak creation
is deterministic and occurs locally at the downstream tip. Because of the up/downstream
symmetry, Couette stripes, in contrast to Poiseuille stripes, have two weak and
two strong laminar turbulent interfaces. These differences in symmetry as well
as in internal growth give rise to two fundamentally different stripe splitting
mechanisms. In plane-Poiseuille flow splitting is connected to the elongational
growth of the original stripe, and it results from a break-off/shedding of the
stripe's tail. In plane-Couette flow splitting follows from a broadening of the
original stripe and a division along the stripe into two slimmer stripes.
acknowledgement: E.M. acknowledges funding from the ISTplus fellowship programme.
G.Y. and B.H. acknowledge a grant from the Simons Foundation (662960, BH).
article_number: A21
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Elena
full_name: Marensi, Elena
id: 0BE7553A-1004-11EA-B805-18983DDC885E
last_name: Marensi
orcid: 0000-0001-7173-4923
- first_name: Gökhan
full_name: Yalniz, Gökhan
id: 66E74FA2-D8BF-11E9-8249-8DE2E5697425
last_name: Yalniz
orcid: 0000-0002-8490-9312
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
citation:
ama: Marensi E, Yalniz G, Hof B. Dynamics and proliferation of turbulent stripes
in plane-Poiseuille and plane-Couette flows. Journal of Fluid Mechanics.
2023;974. doi:10.1017/jfm.2023.780
apa: Marensi, E., Yalniz, G., & Hof, B. (2023). Dynamics and proliferation of
turbulent stripes in plane-Poiseuille and plane-Couette flows. Journal of Fluid
Mechanics. Cambridge University Press. https://doi.org/10.1017/jfm.2023.780
chicago: Marensi, Elena, Gökhan Yalniz, and Björn Hof. “Dynamics and Proliferation
of Turbulent Stripes in Plane-Poiseuille and Plane-Couette Flows.” Journal
of Fluid Mechanics. Cambridge University Press, 2023. https://doi.org/10.1017/jfm.2023.780.
ieee: E. Marensi, G. Yalniz, and B. Hof, “Dynamics and proliferation of turbulent
stripes in plane-Poiseuille and plane-Couette flows,” Journal of Fluid Mechanics,
vol. 974. Cambridge University Press, 2023.
ista: Marensi E, Yalniz G, Hof B. 2023. Dynamics and proliferation of turbulent
stripes in plane-Poiseuille and plane-Couette flows. Journal of Fluid Mechanics.
974, A21.
mla: Marensi, Elena, et al. “Dynamics and Proliferation of Turbulent Stripes in
Plane-Poiseuille and Plane-Couette Flows.” Journal of Fluid Mechanics,
vol. 974, A21, Cambridge University Press, 2023, doi:10.1017/jfm.2023.780.
short: E. Marensi, G. Yalniz, B. Hof, Journal of Fluid Mechanics 974 (2023).
date_created: 2023-10-30T09:32:28Z
date_published: 2023-11-10T00:00:00Z
date_updated: 2024-02-15T09:06:23Z
day: '10'
ddc:
- '530'
department:
- _id: GradSch
- _id: BjHo
doi: 10.1017/jfm.2023.780
external_id:
arxiv:
- '2212.12406'
isi:
- '001088363700001'
file:
- access_level: open_access
checksum: 17c64c1fb0d5f73252364bf98b0b9e1a
content_type: application/pdf
creator: dernst
date_created: 2024-02-15T09:05:21Z
date_updated: 2024-02-15T09:05:21Z
file_id: '14996'
file_name: 2023_JourFluidMechanics_Marensi.pdf
file_size: 2804641
relation: main_file
success: 1
file_date_updated: 2024-02-15T09:05:21Z
has_accepted_license: '1'
intvolume: ' 974'
isi: 1
keyword:
- turbulence
- transition to turbulence
- patterns
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 238598C6-32DE-11EA-91FC-C7463DDC885E
grant_number: '662960'
name: 'Revisiting the Turbulence Problem Using Statistical Mechanics: Experimental
Studies on Transitional and Turbulent Flows'
publication: Journal of Fluid Mechanics
publication_identifier:
eissn:
- 1469-7645
issn:
- 0022-1120
publication_status: published
publisher: Cambridge University Press
quality_controlled: '1'
status: public
title: Dynamics and proliferation of turbulent stripes in plane-Poiseuille and plane-Couette
flows
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 974
year: '2023'
...
---
_id: '14687'
abstract:
- lang: eng
text: The short history of research on Li-O2 batteries has seen a remarkable number
of mechanistic U-turns over the years. From the initial use of carbonate electrolytes,
that were then found to be entirely unsuitable, to the belief that (su)peroxide
was solely responsible for degradation, before the more reactive singlet oxygen
was found to form, to the hypothesis that capacity depends on a competing surface/solution
mechanism before a practically exclusive solution mechanism was identified. Herein,
we argue for an ever-fresh look at the reported data without bias towards supposedly
established explanations. We explain how the latest findings on rate and capacity
limits, as well as the origin of side reactions, are connected via the disproportionation
(DISP) step in the (dis)charge mechanism. Therefrom, directions emerge for the
design of electrolytes and mediators on how to suppress side reactions and to
enable high rate and high reversible capacity.
article_number: e202316476
article_processing_charge: Yes (via OA deal)
article_type: review
author:
- first_name: Rajesh B
full_name: Jethwa, Rajesh B
id: 4cc538d5-803f-11ed-ab7e-8139573aad8f
last_name: Jethwa
orcid: 0000-0002-0404-4356
- first_name: Soumyadip
full_name: Mondal, Soumyadip
id: d25d21ef-dc8d-11ea-abe3-ec4576307f48
last_name: Mondal
- first_name: Bhargavi
full_name: Pant, Bhargavi
id: 50c64d4d-eb97-11eb-a6c2-d33e5e14f112
last_name: Pant
- first_name: Stefan Alexander
full_name: Freunberger, Stefan Alexander
id: A8CA28E6-CE23-11E9-AD2D-EC27E6697425
last_name: Freunberger
orcid: 0000-0003-2902-5319
citation:
ama: Jethwa RB, Mondal S, Pant B, Freunberger SA. To DISP or not? The far‐reaching
reaction mechanisms underpinning Lithium‐air batteries. Angewandte Chemie International
Edition. 2023. doi:10.1002/anie.202316476
apa: Jethwa, R. B., Mondal, S., Pant, B., & Freunberger, S. A. (2023). To DISP
or not? The far‐reaching reaction mechanisms underpinning Lithium‐air batteries.
Angewandte Chemie International Edition. Wiley. https://doi.org/10.1002/anie.202316476
chicago: Jethwa, Rajesh B, Soumyadip Mondal, Bhargavi Pant, and Stefan Alexander
Freunberger. “To DISP or Not? The Far‐reaching Reaction Mechanisms Underpinning
Lithium‐air Batteries.” Angewandte Chemie International Edition. Wiley,
2023. https://doi.org/10.1002/anie.202316476.
ieee: R. B. Jethwa, S. Mondal, B. Pant, and S. A. Freunberger, “To DISP or not?
The far‐reaching reaction mechanisms underpinning Lithium‐air batteries,” Angewandte
Chemie International Edition. Wiley, 2023.
ista: Jethwa RB, Mondal S, Pant B, Freunberger SA. 2023. To DISP or not? The far‐reaching
reaction mechanisms underpinning Lithium‐air batteries. Angewandte Chemie International
Edition., e202316476.
mla: Jethwa, Rajesh B., et al. “To DISP or Not? The Far‐reaching Reaction Mechanisms
Underpinning Lithium‐air Batteries.” Angewandte Chemie International Edition,
e202316476, Wiley, 2023, doi:10.1002/anie.202316476.
short: R.B. Jethwa, S. Mondal, B. Pant, S.A. Freunberger, Angewandte Chemie International
Edition (2023).
date_created: 2023-12-15T16:10:13Z
date_published: 2023-12-14T00:00:00Z
date_updated: 2024-02-15T14:43:05Z
day: '14'
department:
- _id: StFr
- _id: GradSch
doi: 10.1002/anie.202316476
keyword:
- General Chemistry
- Catalysis
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.1002/anie.202316476'
month: '12'
oa: 1
oa_version: Published Version
publication: Angewandte Chemie International Edition
publication_identifier:
eissn:
- 1521-3773
issn:
- 1433-7851
publication_status: epub_ahead
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: To DISP or not? The far‐reaching reaction mechanisms underpinning Lithium‐air
batteries
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12675'
abstract:
- lang: eng
text: Aromatic side chains are important reporters of the plasticity of proteins,
and often form important contacts in protein--protein interactions. By studying
a pair of structurally homologous cross-β amyloid fibrils, HET-s and HELLF, with
a specific isotope-labeling approach and magic-angle-spinning (MAS) NMR, we have
characterized the dynamic behavior of Phe and Tyr aromatic rings to show that
the hydrophobic amyloid core is rigid, without any sign of "breathing motions"
over hundreds of milliseconds at least. Aromatic residues exposed at the fibril
surface have a rigid ring axis but undergo ring flips, on a variety of time scales
from ns to µs. Our approach provides direct insight into hydrophobic-core motions,
enabling a better evaluation of the conformational heterogeneity generated from
a NMR structural ensemble of such amyloid cross-β architecture.
acknowledgement: We thank AlbertA. Smith (Leipzig)for insightful discussions. This
work was supported by funding from the European Research Council (StG-2012-311318
to P.S.) and used the platforms of the Grenoble Instruct-ERIC center (ISBG;UMS 3518
CNRS-CEA-UJF-EMBL) within the Grenoble Partnership for Structural Biology(PSB) and
facilities and expertiseof the Biophysical and Structural Chemistry platform (BPCS)
at IECB,CNRSUAR3033,INSERMUS001 and Bordeaux University.
article_number: e202219314
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Lea Marie
full_name: Becker, Lea Marie
id: 36336939-eb97-11eb-a6c2-c83f1214ca79
last_name: Becker
orcid: 0000-0002-6401-5151
- first_name: Mélanie
full_name: Berbon, Mélanie
last_name: Berbon
- first_name: Alicia
full_name: Vallet, Alicia
last_name: Vallet
- first_name: Axelle
full_name: Grelard, Axelle
last_name: Grelard
- first_name: Estelle
full_name: Morvan, Estelle
last_name: Morvan
- first_name: Benjamin
full_name: Bardiaux, Benjamin
last_name: Bardiaux
- first_name: Roman
full_name: Lichtenecker, Roman
last_name: Lichtenecker
- first_name: Matthias
full_name: Ernst, Matthias
last_name: Ernst
- first_name: Antoine
full_name: Loquet, Antoine
last_name: Loquet
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
citation:
ama: Becker LM, Berbon M, Vallet A, et al. The rigid core and flexible surface of
amyloid fibrils probed by Magic‐Angle Spinning NMR of aromatic residues. Angewandte
Chemie International Edition. 2023;62(19). doi:10.1002/anie.202219314
apa: Becker, L. M., Berbon, M., Vallet, A., Grelard, A., Morvan, E., Bardiaux, B.,
… Schanda, P. (2023). The rigid core and flexible surface of amyloid fibrils probed
by Magic‐Angle Spinning NMR of aromatic residues. Angewandte Chemie International
Edition. Wiley. https://doi.org/10.1002/anie.202219314
chicago: Becker, Lea Marie, Mélanie Berbon, Alicia Vallet, Axelle Grelard, Estelle
Morvan, Benjamin Bardiaux, Roman Lichtenecker, Matthias Ernst, Antoine Loquet,
and Paul Schanda. “The Rigid Core and Flexible Surface of Amyloid Fibrils Probed
by Magic‐Angle Spinning NMR of Aromatic Residues.” Angewandte Chemie International
Edition. Wiley, 2023. https://doi.org/10.1002/anie.202219314.
ieee: L. M. Becker et al., “The rigid core and flexible surface of amyloid
fibrils probed by Magic‐Angle Spinning NMR of aromatic residues,” Angewandte
Chemie International Edition, vol. 62, no. 19. Wiley, 2023.
ista: Becker LM, Berbon M, Vallet A, Grelard A, Morvan E, Bardiaux B, Lichtenecker
R, Ernst M, Loquet A, Schanda P. 2023. The rigid core and flexible surface of
amyloid fibrils probed by Magic‐Angle Spinning NMR of aromatic residues. Angewandte
Chemie International Edition. 62(19), e202219314.
mla: Becker, Lea Marie, et al. “The Rigid Core and Flexible Surface of Amyloid Fibrils
Probed by Magic‐Angle Spinning NMR of Aromatic Residues.” Angewandte Chemie
International Edition, vol. 62, no. 19, e202219314, Wiley, 2023, doi:10.1002/anie.202219314.
short: L.M. Becker, M. Berbon, A. Vallet, A. Grelard, E. Morvan, B. Bardiaux, R.
Lichtenecker, M. Ernst, A. Loquet, P. Schanda, Angewandte Chemie International
Edition 62 (2023).
date_created: 2023-02-24T10:45:01Z
date_published: 2023-05-01T00:00:00Z
date_updated: 2024-02-21T12:14:06Z
day: '01'
ddc:
- '540'
department:
- _id: GradSch
- _id: PaSc
doi: 10.1002/anie.202219314
external_id:
isi:
- '000956919900001'
pmid:
- '36738230'
file:
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checksum: 7dd083ed8850faa55c34e411ed390de9
content_type: application/pdf
creator: dernst
date_created: 2023-08-16T12:33:31Z
date_updated: 2023-08-16T12:33:31Z
file_id: '14072'
file_name: 2023_AngewChemInt_Becker.pdf
file_size: 1422445
relation: main_file
success: 1
file_date_updated: 2023-08-16T12:33:31Z
has_accepted_license: '1'
intvolume: ' 62'
isi: 1
issue: '19'
keyword:
- General Chemistry
- Catalysis
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '05'
oa: 1
oa_version: Published Version
pmid: 1
publication: Angewandte Chemie International Edition
publication_identifier:
eissn:
- 1521-3773
issn:
- 1433-7851
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
link:
- description: News on ISTA website
relation: press_release
url: https://ista.ac.at/en/news/dancing-styles-of-atoms/
record:
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relation: other
status: public
- id: '12497'
relation: research_data
status: public
status: public
title: The rigid core and flexible surface of amyloid fibrils probed by Magic‐Angle
Spinning NMR of aromatic residues
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 62
year: '2023'
...
---
_id: '12497'
abstract:
- lang: eng
text: Aromatic side chains are important reporters of the plasticity of proteins,
and often form important contacts in protein–protein interactions. We studied
aromatic residues in the two structurally homologous cross-β amyloid fibrils HET-s,
and HELLF by employing a specific isotope-labeling approach and magic-angle-spinning
NMR. The dynamic behavior of the aromatic residues Phe and Tyr indicates that
the hydrophobic amyloid core is rigid, without any sign of "breathing motions"
over hundreds of milliseconds at least. Aromatic residues exposed at the fibril
surface have a rigid ring axis but undergo ring flips on a variety of time scales
from nanoseconds to microseconds. Our approach provides direct insight into hydrophobic-core
motions, enabling a better evaluation of the conformational heterogeneity generated
from an NMR structural ensemble of such amyloid cross-β architecture.
article_processing_charge: No
author:
- first_name: Lea Marie
full_name: Becker, Lea Marie
id: 36336939-eb97-11eb-a6c2-c83f1214ca79
last_name: Becker
orcid: 0000-0002-6401-5151
- first_name: Paul
full_name: Schanda, Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
citation:
ama: 'Becker LM, Schanda P. Research data to: The rigid core and flexible surface
of amyloid fibrils probed by magic-angle-spinning NMR spectroscopy of aromatic
residues. 2023. doi:10.15479/AT:ISTA:12497'
apa: 'Becker, L. M., & Schanda, P. (2023). Research data to: The rigid core
and flexible surface of amyloid fibrils probed by magic-angle-spinning NMR spectroscopy
of aromatic residues. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:12497'
chicago: 'Becker, Lea Marie, and Paul Schanda. “Research Data to: The Rigid Core
and Flexible Surface of Amyloid Fibrils Probed by Magic-Angle-Spinning NMR Spectroscopy
of Aromatic Residues.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/AT:ISTA:12497.'
ieee: 'L. M. Becker and P. Schanda, “Research data to: The rigid core and flexible
surface of amyloid fibrils probed by magic-angle-spinning NMR spectroscopy of
aromatic residues.” Institute of Science and Technology Austria, 2023.'
ista: 'Becker LM, Schanda P. 2023. Research data to: The rigid core and flexible
surface of amyloid fibrils probed by magic-angle-spinning NMR spectroscopy of
aromatic residues, Institute of Science and Technology Austria, 10.15479/AT:ISTA:12497.'
mla: 'Becker, Lea Marie, and Paul Schanda. Research Data to: The Rigid Core and
Flexible Surface of Amyloid Fibrils Probed by Magic-Angle-Spinning NMR Spectroscopy
of Aromatic Residues. Institute of Science and Technology Austria, 2023, doi:10.15479/AT:ISTA:12497.'
short: L.M. Becker, P. Schanda, (2023).
contributor:
- contributor_type: researcher
first_name: Mélanie
last_name: Berbon
- contributor_type: researcher
first_name: Alicia
last_name: Vallet
- contributor_type: researcher
first_name: Axelle
last_name: Grelard
- contributor_type: researcher
first_name: Estelle
last_name: Morvan
- contributor_type: researcher
first_name: Benjamin
last_name: Bardiaux
- contributor_type: researcher
first_name: Roman
last_name: Lichtenecker
- contributor_type: researcher
first_name: Matthias
last_name: Ernst
- contributor_type: researcher
first_name: Antoine
last_name: Loquet
- contributor_type: contact_person
first_name: Paul
id: 7B541462-FAF6-11E9-A490-E8DFE5697425
last_name: Schanda
orcid: 0000-0002-9350-7606
- contributor_type: researcher
first_name: Lea Marie
id: 36336939-eb97-11eb-a6c2-c83f1214ca79
last_name: Becker
orcid: 0000-0002-6401-5151
date_created: 2023-02-03T08:08:02Z
date_published: 2023-03-23T00:00:00Z
date_updated: 2024-02-21T12:14:06Z
day: '23'
ddc:
- '572'
department:
- _id: GradSch
- _id: PaSc
doi: 10.15479/AT:ISTA:12497
file:
- access_level: open_access
checksum: fd9a28620a81a82991fb70f4fd6591d9
content_type: application/zip
creator: lbecker
date_created: 2023-03-23T10:03:16Z
date_updated: 2023-03-24T09:34:20Z
file_id: '12743'
file_name: Research_Data.zip
file_size: 87018103
relation: main_file
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checksum: 30ebdfb600af118fcf8518b6efe0b7e9
content_type: text/plain
creator: dernst
date_created: 2023-03-24T07:13:55Z
date_updated: 2023-03-24T09:42:03Z
file_id: '12755'
file_name: README.txt
file_size: 747
relation: main_file
file_date_updated: 2023-03-24T09:42:03Z
has_accepted_license: '1'
keyword:
- aromatic side chains
- isotopic labeling
- protein dynamics
- ring flips
- spin relaxation
month: '03'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '12675'
relation: used_in_publication
status: public
status: public
title: 'Research data to: The rigid core and flexible surface of amyloid fibrils probed
by magic-angle-spinning NMR spectroscopy of aromatic residues'
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '13314'
abstract:
- lang: eng
text: The emergence of large-scale order in self-organized systems relies on local
interactions between individual components. During bacterial cell division, FtsZ—a
prokaryotic homologue of the eukaryotic protein tubulin—polymerizes into treadmilling
filaments that further organize into a cytoskeletal ring. In vitro, FtsZ filaments
can form dynamic chiral assemblies. However, how the active and passive properties
of individual filaments relate to these large-scale self-organized structures
remains poorly understood. Here we connect single-filament properties with the
mesoscopic scale by combining minimal active matter simulations and biochemical
reconstitution experiments. We show that the density and flexibility of active
chiral filaments define their global order. At intermediate densities, curved,
flexible filaments organize into chiral rings and polar bands. An effectively
nematic organization dominates for high densities and for straight, mutant filaments
with increased rigidity. Our predicted phase diagram quantitatively captures these
features, demonstrating how the flexibility, density and chirality of the active
filaments affect their collective behaviour. Our findings shed light on the fundamental
properties of active chiral matter and explain how treadmilling FtsZ filaments
organize during bacterial cell division.
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
acknowledgement: 'This work was supported by the European Research Council through
grant ERC 2015-StG-679239 and by the Austrian Science Fund (FWF) StandAlone P34607
to M.L., B. P.M. was also supported by the Kanazawa University WPI- NanoLSI Bio-SPM
collaborative research program. Z.D. has received funding from Doctoral Programme
of the Austrian Academy of Sciences (OeAW): Grant agreement 26360. We thank Jan
Brugues (MPI CBG, Dresden, Germany), Andela Saric (ISTA, Klosterneuburg, Austria),
Daniel Pearce (Uni Geneva, Switzerland) for valuable scientific input and comments
on the manuscript. We are also thankful for the support by the Scientific Service
Units (SSU) of IST Austria through resources provided by the Imaging and Optics
Facility (IOF) and the Lab Support Facility (LSF).'
article_processing_charge: Yes (in subscription journal)
article_type: original
author:
- first_name: Zuzana
full_name: Dunajova, Zuzana
id: 4B39F286-F248-11E8-B48F-1D18A9856A87
last_name: Dunajova
- first_name: Batirtze
full_name: Prats Mateu, Batirtze
id: 299FE892-F248-11E8-B48F-1D18A9856A87
last_name: Prats Mateu
- first_name: Philipp
full_name: Radler, Philipp
id: 40136C2A-F248-11E8-B48F-1D18A9856A87
last_name: Radler
orcid: '0000-0001-9198-2182 '
- first_name: Keesiang
full_name: Lim, Keesiang
last_name: Lim
- first_name: Dörte
full_name: Brandis, Dörte
id: 21d64d35-f128-11eb-9611-b8bcca7a12fd
last_name: Brandis
- first_name: Philipp
full_name: Velicky, Philipp
id: 39BDC62C-F248-11E8-B48F-1D18A9856A87
last_name: Velicky
orcid: 0000-0002-2340-7431
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
- first_name: Richard W.
full_name: Wong, Richard W.
last_name: Wong
- first_name: Jens
full_name: Elgeti, Jens
last_name: Elgeti
- first_name: Edouard B
full_name: Hannezo, Edouard B
id: 3A9DB764-F248-11E8-B48F-1D18A9856A87
last_name: Hannezo
orcid: 0000-0001-6005-1561
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
citation:
ama: Dunajova Z, Prats Mateu B, Radler P, et al. Chiral and nematic phases of flexible
active filaments. Nature Physics. 2023;19:1916-1926. doi:10.1038/s41567-023-02218-w
apa: Dunajova, Z., Prats Mateu, B., Radler, P., Lim, K., Brandis, D., Velicky, P.,
… Loose, M. (2023). Chiral and nematic phases of flexible active filaments. Nature
Physics. Springer Nature. https://doi.org/10.1038/s41567-023-02218-w
chicago: Dunajova, Zuzana, Batirtze Prats Mateu, Philipp Radler, Keesiang Lim, Dörte
Brandis, Philipp Velicky, Johann G Danzl, et al. “Chiral and Nematic Phases of
Flexible Active Filaments.” Nature Physics. Springer Nature, 2023. https://doi.org/10.1038/s41567-023-02218-w.
ieee: Z. Dunajova et al., “Chiral and nematic phases of flexible active filaments,”
Nature Physics, vol. 19. Springer Nature, pp. 1916–1926, 2023.
ista: Dunajova Z, Prats Mateu B, Radler P, Lim K, Brandis D, Velicky P, Danzl JG,
Wong RW, Elgeti J, Hannezo EB, Loose M. 2023. Chiral and nematic phases of flexible
active filaments. Nature Physics. 19, 1916–1926.
mla: Dunajova, Zuzana, et al. “Chiral and Nematic Phases of Flexible Active Filaments.”
Nature Physics, vol. 19, Springer Nature, 2023, pp. 1916–26, doi:10.1038/s41567-023-02218-w.
short: Z. Dunajova, B. Prats Mateu, P. Radler, K. Lim, D. Brandis, P. Velicky, J.G.
Danzl, R.W. Wong, J. Elgeti, E.B. Hannezo, M. Loose, Nature Physics 19 (2023)
1916–1926.
date_created: 2023-07-27T14:44:45Z
date_published: 2023-12-01T00:00:00Z
date_updated: 2024-02-21T12:19:08Z
day: '01'
ddc:
- '530'
department:
- _id: JoDa
- _id: EdHa
- _id: MaLo
- _id: GradSch
doi: 10.1038/s41567-023-02218-w
ec_funded: 1
external_id:
pmid:
- '38075437'
file:
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checksum: bc7673ca07d37309013a86166577b2f7
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has_accepted_license: '1'
intvolume: ' 19'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 1916-1926
pmid: 1
project:
- _id: 2595697A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '679239'
name: Self-Organization of the Bacterial Cell
- _id: fc38323b-9c52-11eb-aca3-ff8afb4a011d
grant_number: P34607
name: "Understanding bacterial cell division by in vitro\r\nreconstitution"
- _id: 34d75525-11ca-11ed-8bc3-89b6307fee9d
grant_number: '26360'
name: Motile active matter models of migrating cells and chiral filaments
publication: Nature Physics
publication_identifier:
eissn:
- 1745-2481
issn:
- 1745-2473
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
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relation: research_data
status: public
scopus_import: '1'
status: public
title: Chiral and nematic phases of flexible active filaments
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2023'
...
---
_id: '14280'
abstract:
- lang: eng
text: "Cell division in Escherichia coli is performed by the divisome, a multi-protein
complex composed of more than 30 proteins. The divisome spans from the cytoplasm
through the inner membrane to the cell wall and the outer membrane. Divisome assembly
is initiated by a cytoskeletal structure, the so-called Z-ring, which localizes
at the center of the E. coli cell and determines the position of the future cell
septum. The Z-ring is composed of the highly conserved bacterial tubulin homologue
FtsZ, which forms treadmilling filaments. These filaments are recruited to the
inner membrane by FtsA, a highly conserved bacterial actin homologue. FtsA interacts
with other proteins in the periplasm and thus connects the cytoplasmic and periplasmic
components of the divisome. \r\nA previous model postulated that FtsA regulates
maturation of the divisome by switching from an oligomeric, inactive state to
a monomeric and active state. This model was based mostly on in vivo studies,
as a biochemical characterization of FtsA has been hampered by difficulties in
purifying the protein. Here, we studied FtsA using an in vitro reconstitution
approach and aimed to answer two questions: (i) How are dynamics from cytoplasmic,
treadmilling FtsZ filaments coupled to proteins acting in the periplasmic space
and (ii) How does FtsA regulate the maturation of the divisome?\r\nWe found that
the cytoplasmic peptides of the transmembrane proteins FtsN and FtsQ interact
directly with FtsA and can follow the spatiotemporal signal of FtsA/Z filaments.
When we investigated the underlying mechanism by imaging single molecules of FtsNcyto,
we found the peptide to interact transiently with FtsA. An in depth analysis of
the single molecule trajectories helped to postulate a model where PG synthases
follow the dynamics of FtsZ by a diffusion and capture mechanism. \r\nFollowing
up on these findings we were interested in how the self-interaction of FtsA changes
when it encounters FtsNcyto and if we can confirm the proposed oligomer-monomer
switch. For this, we compared the behavior of the previously identified, hyperactive
mutant FtsA R286W with wildtype FtsA. The mutant outperforms WT in mirroring and
transmitting the spatiotemporal signal of treadmilling FtsZ filaments. Surprisingly
however, we found that this was not due to a difference in the self-interaction
strength of the two variants, but a difference in their membrane residence time.
Furthermore, in contrast to our expectations, upon binding of FtsNcyto the measured
self-interaction of FtsA actually increased. \r\nWe propose that FtsNcyto induces
a rearrangement of the oligomeric architecture of FtsA. In further consequence
this change leads to more persistent FtsZ filaments which results in a defined
signalling zone, allowing formation of the mature divisome. The observed difference
between FtsA WT and R286W is due to the vastly different membrane turnover of
the proteins. R286W cycles 5-10x faster compared to WT which allows to sample
FtsZ filaments at faster frequencies. These findings can explain the observed
differences in toxicity for overexpression of FtsA WT and R286W and help to understand
how FtsA regulates divisome maturation."
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Philipp
full_name: Radler, Philipp
id: 40136C2A-F248-11E8-B48F-1D18A9856A87
last_name: Radler
orcid: '0000-0001-9198-2182 '
citation:
ama: Radler P. Spatiotemporal signaling during assembly of the bacterial divisome.
2023. doi:10.15479/at:ista:14280
apa: Radler, P. (2023). Spatiotemporal signaling during assembly of the bacterial
divisome. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14280
chicago: Radler, Philipp. “Spatiotemporal Signaling during Assembly of the Bacterial
Divisome.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:14280.
ieee: P. Radler, “Spatiotemporal signaling during assembly of the bacterial divisome,”
Institute of Science and Technology Austria, 2023.
ista: Radler P. 2023. Spatiotemporal signaling during assembly of the bacterial
divisome. Institute of Science and Technology Austria.
mla: Radler, Philipp. Spatiotemporal Signaling during Assembly of the Bacterial
Divisome. Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:14280.
short: P. Radler, Spatiotemporal Signaling during Assembly of the Bacterial Divisome,
Institute of Science and Technology Austria, 2023.
date_created: 2023-09-06T10:58:25Z
date_published: 2023-09-25T00:00:00Z
date_updated: 2024-02-21T12:35:18Z
day: '25'
ddc:
- '572'
degree_awarded: PhD
department:
- _id: GradSch
- _id: MaLo
doi: 10.15479/at:ista:14280
ec_funded: 1
file:
- access_level: closed
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creator: pradler
date_created: 2023-10-04T10:11:53Z
date_updated: 2023-10-04T10:28:35Z
file_id: '14390'
file_name: PhD Thesis_Philipp Radler_20231004.docx
file_size: 114932847
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file_name: PhD Thesis_Philipp Radler_20231004.pdf
file_size: 37838778
relation: main_file
file_date_updated: 2023-10-04T10:28:35Z
has_accepted_license: '1'
keyword:
- Cell Division
- Reconstitution
- FtsZ
- FtsA
- Divisome
- E.coli
language:
- iso: eng
month: '09'
oa_version: Published Version
page: '156'
project:
- _id: 2595697A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '679239'
name: Self-Organization of the Bacterial Cell
- _id: fc38323b-9c52-11eb-aca3-ff8afb4a011d
grant_number: P34607
name: "Understanding bacterial cell division by in vitro\r\nreconstitution"
- _id: 2596EAB6-B435-11E9-9278-68D0E5697425
grant_number: ALTF 2015-1163
name: Synthesis of bacterial cell wall
- _id: 259B655A-B435-11E9-9278-68D0E5697425
grant_number: LT000824/2016
name: Reconstitution of bacterial cell wall sythesis
publication_identifier:
isbn:
- 978-3-99078-033-6
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '11373'
relation: part_of_dissertation
status: public
- id: '7387'
relation: part_of_dissertation
status: public
- id: '10934'
relation: research_data
status: public
status: public
supervisor:
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
title: Spatiotemporal signaling during assembly of the bacterial divisome
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '13286'
abstract:
- lang: eng
text: Semiconductor-superconductor hybrid systems are the harbour of many intriguing
mesoscopic phenomena. This material combination leads to spatial variations of
the superconducting properties, which gives rise to Andreev bound states (ABSs).
Some of these states might exhibit remarkable properties that render them highly
desirable for topological quantum computing. The most prominent and hunted of
such states are Majorana zero modes (MZMs), quasiparticles equals to their own
quasiparticles that they follow non-abelian statistics. In this thesis, we first
introduce the general framework of such hybrid systems and, then, we unveil a
series of mesoscopic phenomena that we discovered. Firstly, we show tunneling
spectroscopy experiments on full-shell nanowires (NWs) showing that unwanted quantum-dot
states coupled to superconductors (Yu-Shiba-Rusinov states) can mimic MZMs signatures.
Then, we introduce a novel protocol which allowed the integration of tunneling
spectroscopy with Coulomb spectroscopy within the same device. Employing this
approach on both full-shell NWs and partial-shell NWs, we demonstrated that longitudinally
confined states reveal charge transport phenomenology similar to the one expected
for MZMs. These findings shed light on the intricate interplay between superconductivity
and quantum confinement, which brought us to explore another material platform,
i.e. a two-dimensional Germanium hole gas. After developing a robust way to induce
superconductivity in such system, we showed how to engineer the proximity effect
and we revealed a superconducting hard gap. Finally, we created a superconducting
radio frequency driven ideal diode and a generator of non-sinusoidal current-phase
relations. Our results open the path for the exploration of protected superconducting
qubits and more complex hybrid devices in planar Germanium, like Kitaev chains
and hybrid qubit devices.
acknowledged_ssus:
- _id: NanoFab
- _id: M-Shop
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Marco
full_name: Valentini, Marco
id: C0BB2FAC-D767-11E9-B658-BC13E6697425
last_name: Valentini
citation:
ama: 'Valentini M. Mesoscopic phenomena in hybrid semiconductor-superconductor nanodevices :
From full-shell nanowires to two-dimensional hole gas in germanium. 2023. doi:10.15479/at:ista:13286'
apa: 'Valentini, M. (2023). Mesoscopic phenomena in hybrid semiconductor-superconductor
nanodevices : From full-shell nanowires to two-dimensional hole gas in germanium.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:13286'
chicago: 'Valentini, Marco. “Mesoscopic Phenomena in Hybrid Semiconductor-Superconductor
Nanodevices : From Full-Shell Nanowires to Two-Dimensional Hole Gas in Germanium.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:13286.'
ieee: 'M. Valentini, “Mesoscopic phenomena in hybrid semiconductor-superconductor
nanodevices : From full-shell nanowires to two-dimensional hole gas in germanium,”
Institute of Science and Technology Austria, 2023.'
ista: 'Valentini M. 2023. Mesoscopic phenomena in hybrid semiconductor-superconductor
nanodevices : From full-shell nanowires to two-dimensional hole gas in germanium.
Institute of Science and Technology Austria.'
mla: 'Valentini, Marco. Mesoscopic Phenomena in Hybrid Semiconductor-Superconductor
Nanodevices : From Full-Shell Nanowires to Two-Dimensional Hole Gas in Germanium.
Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:13286.'
short: 'M. Valentini, Mesoscopic Phenomena in Hybrid Semiconductor-Superconductor
Nanodevices : From Full-Shell Nanowires to Two-Dimensional Hole Gas in Germanium,
Institute of Science and Technology Austria, 2023.'
date_created: 2023-07-24T14:10:45Z
date_published: 2023-07-21T00:00:00Z
date_updated: 2024-02-21T12:35:34Z
day: '21'
ddc:
- '530'
degree_awarded: PhD
department:
- _id: GradSch
- _id: GeKa
doi: 10.15479/at:ista:13286
ec_funded: 1
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date_updated: 2023-08-11T10:01:34Z
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file_name: PhD_thesis_Valentini_final_validated.pdf
file_size: 38199711
relation: main_file
file_date_updated: 2023-08-11T14:39:17Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: '184'
project:
- _id: 262116AA-B435-11E9-9278-68D0E5697425
name: Hybrid Semiconductor - Superconductor Quantum Devices
- _id: 237E5020-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '862046'
name: TOPOLOGICALLY PROTECTED AND SCALABLE QUANTUM BITS
- _id: 34a66131-11ca-11ed-8bc3-a31681c6b03e
grant_number: F8606
name: Conventional and unconventional topological superconductors
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '13312'
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status: public
- id: '12118'
relation: part_of_dissertation
status: public
- id: '8910'
relation: part_of_dissertation
status: public
- id: '12522'
relation: research_data
status: public
status: public
supervisor:
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
title: 'Mesoscopic phenomena in hybrid semiconductor-superconductor nanodevices :
From full-shell nanowires to two-dimensional hole gas in germanium'
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14260'
abstract:
- lang: eng
text: "This paper presents Lincheck, a new practical and user-friendly framework
for testing concurrent algorithms on the Java Virtual Machine (JVM). Lincheck
provides a simple and declarative way to write concurrent tests: instead of describing
how to perform the test, users specify what to test by declaring all the operations
to examine; the framework automatically handles the rest. As a result, tests written
with Lincheck are concise and easy to understand. The framework automatically
generates a set of concurrent scenarios, examines them using stress-testing or
bounded model checking, and verifies that the results of each invocation are correct.
Notably, if an error is detected via model checking, Lincheck provides an easy-to-follow
trace to reproduce it, significantly simplifying the bug investigation.\r\n\r\nTo
the best of our knowledge, Lincheck is the first production-ready tool on the
JVM that offers such a simple way of writing concurrent tests, without requiring
special skills or expertise. We successfully integrated Lincheck in the development
process of several large projects, such as Kotlin Coroutines, and identified new
bugs in popular concurrency libraries, such as a race in Java’s standard ConcurrentLinkedDeque
and a liveliness bug in Java’s AbstractQueuedSynchronizer framework, which is
used in most of the synchronization primitives. We believe that Lincheck can significantly
improve the quality and productivity of concurrent algorithms research and development
and become the state-of-the-art tool for checking their correctness."
alternative_title:
- LNCS
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Nikita
full_name: Koval, Nikita
id: 2F4DB10C-F248-11E8-B48F-1D18A9856A87
last_name: Koval
- first_name: Alexander
full_name: Fedorov, Alexander
id: 2e711909-896a-11ed-bdf8-eb0f5a2984c6
last_name: Fedorov
- first_name: Maria
full_name: Sokolova, Maria
last_name: Sokolova
- first_name: Dmitry
full_name: Tsitelov, Dmitry
last_name: Tsitelov
- first_name: Dan-Adrian
full_name: Alistarh, Dan-Adrian
id: 4A899BFC-F248-11E8-B48F-1D18A9856A87
last_name: Alistarh
orcid: 0000-0003-3650-940X
citation:
ama: 'Koval N, Fedorov A, Sokolova M, Tsitelov D, Alistarh D-A. Lincheck: A practical
framework for testing concurrent data structures on JVM. In: 35th International
Conference on Computer Aided Verification . Vol 13964. Springer Nature; 2023:156-169.
doi:10.1007/978-3-031-37706-8_8'
apa: 'Koval, N., Fedorov, A., Sokolova, M., Tsitelov, D., & Alistarh, D.-A.
(2023). Lincheck: A practical framework for testing concurrent data structures
on JVM. In 35th International Conference on Computer Aided Verification
(Vol. 13964, pp. 156–169). Paris, France: Springer Nature. https://doi.org/10.1007/978-3-031-37706-8_8'
chicago: 'Koval, Nikita, Alexander Fedorov, Maria Sokolova, Dmitry Tsitelov, and
Dan-Adrian Alistarh. “Lincheck: A Practical Framework for Testing Concurrent Data
Structures on JVM.” In 35th International Conference on Computer Aided Verification
, 13964:156–69. Springer Nature, 2023. https://doi.org/10.1007/978-3-031-37706-8_8.'
ieee: 'N. Koval, A. Fedorov, M. Sokolova, D. Tsitelov, and D.-A. Alistarh, “Lincheck:
A practical framework for testing concurrent data structures on JVM,” in 35th
International Conference on Computer Aided Verification , Paris, France, 2023,
vol. 13964, pp. 156–169.'
ista: 'Koval N, Fedorov A, Sokolova M, Tsitelov D, Alistarh D-A. 2023. Lincheck:
A practical framework for testing concurrent data structures on JVM. 35th International
Conference on Computer Aided Verification . CAV: Computer Aided Verification,
LNCS, vol. 13964, 156–169.'
mla: 'Koval, Nikita, et al. “Lincheck: A Practical Framework for Testing Concurrent
Data Structures on JVM.” 35th International Conference on Computer Aided Verification
, vol. 13964, Springer Nature, 2023, pp. 156–69, doi:10.1007/978-3-031-37706-8_8.'
short: N. Koval, A. Fedorov, M. Sokolova, D. Tsitelov, D.-A. Alistarh, in:, 35th
International Conference on Computer Aided Verification , Springer Nature, 2023,
pp. 156–169.
conference:
end_date: 2023-07-22
location: Paris, France
name: 'CAV: Computer Aided Verification'
start_date: 2023-07-17
date_created: 2023-09-03T22:01:16Z
date_published: 2023-07-17T00:00:00Z
date_updated: 2024-02-27T07:46:52Z
day: '17'
ddc:
- '000'
department:
- _id: DaAl
- _id: GradSch
doi: 10.1007/978-3-031-37706-8_8
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creator: dernst
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intvolume: ' 13964'
language:
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month: '07'
oa: 1
oa_version: Published Version
page: 156-169
publication: '35th International Conference on Computer Aided Verification '
publication_identifier:
eissn:
- 1611-3349
isbn:
- '9783031377051'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
related_material:
record:
- id: '14995'
relation: research_data
status: public
scopus_import: '1'
status: public
title: 'Lincheck: A practical framework for testing concurrent data structures on JVM'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 13964
year: '2023'
...
---
_id: '13984'
abstract:
- lang: eng
text: "Social insects fight disease using their individual immune systems and the
cooperative\r\nsanitary behaviors of colony members. These social defenses are
well explored against\r\nexternally-infecting pathogens, but little is known about
defense strategies against\r\ninternally-infecting pathogens, such as viruses.
Viruses are ubiquitous and in the last decades\r\nit has become evident that also
many ant species harbor viruses. We present one of the first\r\nstudies addressing
transmission dynamics and collective disease defenses against viruses in\r\nants
on a mechanistic level. I successfully established an experimental ant host –
viral\r\npathogen system as a model for the defense strategies used by social
insects against internal\r\npathogen infections, as outlined in the third chapter.
In particular, we studied how garden ants\r\n(Lasius neglectus) defend themselves
and their colonies against the generalist insect virus\r\nCrPV (cricket paralysis
virus). We chose microinjections of virus directly into the ants’\r\nhemolymph
because it allowed us to use a defined exposure dose. Here we show that this is
a\r\ngood model system, as the virus is replicating and thus infecting the host.
The ants mount a\r\nclear individual immune response against the viral infection,
which is characterized by a\r\nspecific siRNA pattern, namely siRNAs mapping against
the viral genome with a peak of 21\r\nand 22 bp long fragments. The onset of this
immune response is consistent with the timeline\r\nof viral replication that starts
already within two days post injection. The disease manifests in\r\ndecreased
survival over a course of two to three weeks.\r\nRegarding group living, we find
that infected ants show a strong individual immune response,\r\nbut that their
course of disease is little affected by nestmate presence, as described in chapter\r\nfour.
Hence, we do not find social immunity in the context of viral infections in ants.\r\nNestmates,
however, can contract the virus. Using Drosophila S2R+ cells in culture, we\r\nshowed
that 94 % of the nestmates contract active virus within four days of social contact
to\r\nan infected individual. Virus is transmitted in low doses, thus not causing
disease\r\ntransmission within the colony. While virus can be transmitted during
short direct contacts,\r\nwe also assume transmission from deceased ants and show
that the nestmates’ immune\r\nsystem gets activated after contracting a low viral
dose. We find considerable potential for\r\nindirect transmission via the nest
space. Virus is shed to the nest, where it stays viable for one\r\nweek and is
also picked up by other ants. Apart from that, we want to underline the potential\r\nof
ant poison as antiviral agent. We determined that ant poison successfully inactivates
CrPV\r\nin vitro. However, we found no evidence for effective poison use to sanitize
the nest space.\r\nOn the other hand, local application of ant poison by oral
poison uptake, which is part of the\r\nants prophylactic behavioral repertoire,
probably contributes to keeping the gut of each\r\nindividual sanitized. We hypothesize
that oral poison uptake might be the reason why we did\r\nnot find viable virus
in the trophallactic fluid.\r\nThe fifth chapter encompasses preliminary data
on potential social immunization. However,\r\nour experiments do not confirm an
actual survival benefit for the nestmates upon pathogen\r\nchallenge under the
given experimental settings. Nevertheless, we do not want to rule out the\r\npossibility
for nestmate immunization, but rather emphasize that considering different\r\nexperimental
timelines and viral doses would provide a multitude of options for follow-up\r\nexperiments.\r\nIn
conclusion, we find that prophylactic individual behaviors, such as oral poison
uptake,\r\nmight play a role in preventing viral disease transmission. Compared
to colony defense\r\nagainst external pathogens, internal pathogen infections
require a stronger component of\r\nindividual physiological immunity than behavioral
social immunity, yet could still lead to\r\ncollective protection."
acknowledged_ssus:
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Anna
full_name: Franschitz, Anna
id: 480826C8-F248-11E8-B48F-1D18A9856A87
last_name: Franschitz
citation:
ama: Franschitz A. Individual and social immunity against viral infections in ants.
2023. doi:10.15479/at:ista:13984
apa: Franschitz, A. (2023). Individual and social immunity against viral infections
in ants. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:13984
chicago: Franschitz, Anna. “Individual and Social Immunity against Viral Infections
in Ants.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:13984.
ieee: A. Franschitz, “Individual and social immunity against viral infections in
ants,” Institute of Science and Technology Austria, 2023.
ista: Franschitz A. 2023. Individual and social immunity against viral infections
in ants. Institute of Science and Technology Austria.
mla: Franschitz, Anna. Individual and Social Immunity against Viral Infections
in Ants. Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:13984.
short: A. Franschitz, Individual and Social Immunity against Viral Infections in
Ants, Institute of Science and Technology Austria, 2023.
date_created: 2023-08-08T15:33:29Z
date_published: 2023-08-08T00:00:00Z
date_updated: 2024-03-01T15:25:17Z
day: '08'
ddc:
- '570'
- '577'
degree_awarded: PhD
department:
- _id: GradSch
- _id: SyCr
doi: 10.15479/at:ista:13984
file:
- access_level: closed
checksum: 27220243d5d51c3b0d7d61c0879d7a0c
content_type: application/pdf
creator: afransch
date_created: 2023-08-08T18:01:28Z
date_updated: 2024-03-01T08:51:42Z
embargo: 2024-08-08
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file_size: 10797612
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creator: afransch
date_created: 2023-08-08T18:02:25Z
date_updated: 2023-08-09T07:25:27Z
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file_size: 2619085
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content_type: application/pdf
creator: cchlebak
date_created: 2024-03-01T08:37:15Z
date_updated: 2024-03-01T12:13:29Z
description: Minor modifications and clarifications - Feb 2024
embargo: 2024-08-08
embargo_to: open_access
file_id: '15042'
file_name: Addendum_AnnaFranschitz202402.pdf
file_size: 85956
relation: erratum
title: Addendum
- access_level: closed
checksum: 66745aa01f960f17472c024875c049ed
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: cchlebak
date_created: 2024-03-01T08:39:20Z
date_updated: 2024-03-01T08:51:42Z
file_id: '15043'
file_name: Addendum_AnnaFranschitz202402.docx
file_size: 11818
relation: source_file
title: Addendum - source file
- access_level: closed
checksum: 55c876b73d49db15228a7f571592ec77
content_type: application/pdf
creator: cchlebak
date_created: 2024-03-01T08:56:06Z
date_updated: 2024-03-01T12:58:14Z
description: For printing purposes
file_id: '15044'
file_name: Print_Version_Franschitz_Anna_Thesis.pdf
file_size: 10416761
relation: other
title: Print Version
file_date_updated: 2024-03-01T12:58:14Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa_version: Published Version
page: '89'
publication_identifier:
isbn:
- 978-3-99078-034-3
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
title: Individual and social immunity against viral infections in ants
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '15039'
abstract:
- lang: eng
text: 'A crucial property for achieving secure, trustworthy and interpretable deep
learning systems is their robustness: small changes to a system''s inputs should
not result in large changes to its outputs. Mathematically, this means one strives
for networks with a small Lipschitz constant. Several recent works have focused
on how to construct such Lipschitz networks, typically by imposing constraints
on the weight matrices. In this work, we study an orthogonal aspect, namely the
role of the activation function. We show that commonly used activation functions,
such as MaxMin, as well as all piece-wise linear ones with two segments unnecessarily
restrict the class of representable functions, even in the simplest one-dimensional
setting. We furthermore introduce the new N-activation function that is provably
more expressive than currently popular activation functions. We provide code at
this https URL.'
article_number: '2311.06103'
article_processing_charge: No
author:
- first_name: Bernd
full_name: Prach, Bernd
id: 2D561D42-C427-11E9-89B4-9C1AE6697425
last_name: Prach
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
citation:
ama: Prach B, Lampert C. 1-Lipschitz neural networks are more expressive with N-activations.
arXiv. doi:10.48550/ARXIV.2311.06103
apa: Prach, B., & Lampert, C. (n.d.). 1-Lipschitz neural networks are more expressive
with N-activations. arXiv. https://doi.org/10.48550/ARXIV.2311.06103
chicago: Prach, Bernd, and Christoph Lampert. “1-Lipschitz Neural Networks Are More
Expressive with N-Activations.” ArXiv, n.d. https://doi.org/10.48550/ARXIV.2311.06103.
ieee: B. Prach and C. Lampert, “1-Lipschitz neural networks are more expressive
with N-activations,” arXiv. .
ista: Prach B, Lampert C. 1-Lipschitz neural networks are more expressive with N-activations.
arXiv, 2311.06103.
mla: Prach, Bernd, and Christoph Lampert. “1-Lipschitz Neural Networks Are More
Expressive with N-Activations.” ArXiv, 2311.06103, doi:10.48550/ARXIV.2311.06103.
short: B. Prach, C. Lampert, ArXiv (n.d.).
date_created: 2024-02-28T17:59:32Z
date_published: 2023-11-10T00:00:00Z
date_updated: 2024-03-04T07:02:39Z
day: '10'
department:
- _id: GradSch
- _id: ChLa
doi: 10.48550/ARXIV.2311.06103
external_id:
arxiv:
- '2311.06103'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2311.06103
month: '11'
oa: 1
oa_version: Preprint
publication: arXiv
publication_status: submitted
status: public
title: 1-Lipschitz neural networks are more expressive with N-activations
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '14323'
abstract:
- lang: eng
text: Morphogens are signaling molecules that are known for their prominent role
in pattern formation within developing tissues. In addition to patterning, morphogens
also control tissue growth. However, the underlying mechanisms are poorly understood.
We studied the role of morphogens in regulating tissue growth in the developing
vertebrate neural tube. In this system, opposing morphogen gradients of Shh and
BMP establish the dorsoventral pattern of neural progenitor domains. Perturbations
in these morphogen pathways result in alterations in tissue growth and cell cycle
progression, however, it has been unclear what cellular process is affected. To
address this, we analysed the rates of cell proliferation and cell death in mouse
mutants in which signaling is perturbed, as well as in chick neural plate explants
exposed to defined concentrations of signaling activators or inhibitors. Our results
indicated that the rate of cell proliferation was not altered in these assays.
By contrast, both the Shh and BMP signaling pathways had profound effects on neural
progenitor survival. Our results indicate that these pathways synergise to promote
cell survival within neural progenitors. Consistent with this, we found that progenitors
within the intermediate region of the neural tube, where the combined levels of
Shh and BMP are the lowest, are most prone to cell death when signaling activity
is inhibited. In addition, we found that downregulation of Shh results in increased
apoptosis within the roof plate, which is the dorsal source of BMP ligand production.
This revealed a cross-interaction between the Shh and BMP morphogen signaling
pathways that may be relevant for understanding how gradients scale in neural
tubes with different overall sizes. We further studied the mechanism acting downstream
of Shh in cell survival regulation using genetic and genomic approaches. We propose
that Shh transcriptionally regulates a non-canonical apoptotic pathway. Altogether,
our study points to a novel role of opposing morphogen gradients in tissue size
regulation and provides new insights into complex interactions between Shh and
BMP signaling gradients in the neural tube.
acknowledged_ssus:
- _id: Bio
- _id: PreCl
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Katarzyna
full_name: Kuzmicz-Kowalska, Katarzyna
id: 4CED352A-F248-11E8-B48F-1D18A9856A87
last_name: Kuzmicz-Kowalska
citation:
ama: Kuzmicz-Kowalska K. Regulation of neural progenitor survival by Shh and BMP
in the developing spinal cord. 2023. doi:10.15479/at:ista:14323
apa: Kuzmicz-Kowalska, K. (2023). Regulation of neural progenitor survival by
Shh and BMP in the developing spinal cord. Institute of Science and Technology
Austria. https://doi.org/10.15479/at:ista:14323
chicago: Kuzmicz-Kowalska, Katarzyna. “Regulation of Neural Progenitor Survival
by Shh and BMP in the Developing Spinal Cord.” Institute of Science and Technology
Austria, 2023. https://doi.org/10.15479/at:ista:14323.
ieee: K. Kuzmicz-Kowalska, “Regulation of neural progenitor survival by Shh and
BMP in the developing spinal cord,” Institute of Science and Technology Austria,
2023.
ista: Kuzmicz-Kowalska K. 2023. Regulation of neural progenitor survival by Shh
and BMP in the developing spinal cord. Institute of Science and Technology Austria.
mla: Kuzmicz-Kowalska, Katarzyna. Regulation of Neural Progenitor Survival by
Shh and BMP in the Developing Spinal Cord. Institute of Science and Technology
Austria, 2023, doi:10.15479/at:ista:14323.
short: K. Kuzmicz-Kowalska, Regulation of Neural Progenitor Survival by Shh and
BMP in the Developing Spinal Cord, Institute of Science and Technology Austria,
2023.
date_created: 2023-09-13T10:07:18Z
date_published: 2023-09-13T00:00:00Z
date_updated: 2024-03-07T15:02:59Z
day: '13'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: AnKi
doi: 10.15479/at:ista:14323
file:
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checksum: bd83596869c814b24aeff7077d031c0e
content_type: application/pdf
creator: kkuzmicz
date_created: 2023-09-13T09:52:52Z
date_updated: 2023-09-13T10:08:25Z
embargo: 2025-03-13
embargo_to: open_access
file_id: '14324'
file_name: PhDThesis_KK_final_pdfA.pdf
file_size: 10147911
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creator: kkuzmicz
date_created: 2023-09-13T09:53:29Z
date_updated: 2023-09-13T09:53:29Z
file_id: '14325'
file_name: thesis_KK_final_corrections_092023.docx
file_size: 103980668
relation: source_file
file_date_updated: 2023-09-13T10:08:25Z
has_accepted_license: '1'
language:
- iso: eng
month: '09'
oa_version: Published Version
page: '151'
project:
- _id: 267AF0E4-B435-11E9-9278-68D0E5697425
name: The role of morphogens in the regulation of neural tube growth
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '7883'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
title: Regulation of neural progenitor survival by Shh and BMP in the developing spinal
cord
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14641'
acknowledged_ssus:
- _id: LifeSc
- _id: Bio
- _id: CampIT
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Mike
full_name: Hennessey-Wesen, Mike
id: 3F338C72-F248-11E8-B48F-1D18A9856A87
last_name: Hennessey-Wesen
citation:
ama: Hennessey-Wesen M. Adaptive mutation in E. coli modulated by luxS. 2023. doi:10.15479/at:ista:14641
apa: Hennessey-Wesen, M. (2023). Adaptive mutation in E. coli modulated by luxS.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14641
chicago: Hennessey-Wesen, Mike. “Adaptive Mutation in E. Coli Modulated by LuxS.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:14641.
ieee: M. Hennessey-Wesen, “Adaptive mutation in E. coli modulated by luxS,” Institute
of Science and Technology Austria, 2023.
ista: Hennessey-Wesen M. 2023. Adaptive mutation in E. coli modulated by luxS. Institute
of Science and Technology Austria.
mla: Hennessey-Wesen, Mike. Adaptive Mutation in E. Coli Modulated by LuxS.
Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:14641.
short: M. Hennessey-Wesen, Adaptive Mutation in E. Coli Modulated by LuxS, Institute
of Science and Technology Austria, 2023.
date_created: 2023-12-04T13:17:37Z
date_published: 2023-11-30T00:00:00Z
date_updated: 2024-03-22T13:21:17Z
day: '30'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: BjHo
doi: 10.15479/at:ista:14641
ec_funded: 1
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date_created: 2023-12-06T13:13:26Z
date_updated: 2023-12-06T13:13:26Z
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date_created: 2023-12-06T13:14:15Z
date_updated: 2023-12-06T13:14:15Z
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creator: cchlebak
date_created: 2024-03-20T13:19:36Z
date_updated: 2024-03-20T13:19:36Z
file_id: '15145'
file_name: 2023_Hennessey_Michael_Thesis_from_source.pdf
file_size: 2930287
relation: other
file_date_updated: 2024-03-20T13:19:36Z
has_accepted_license: '1'
keyword:
- microfluidics
- miceobiology
- mutations
- quorum sensing
language:
- iso: eng
month: '11'
oa_version: Published Version
page: '104'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
title: Adaptive mutation in E. coli modulated by luxS
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14587'
abstract:
- lang: eng
text: "This thesis concerns the application of variational methods to the study
of evolution problems arising in fluid mechanics and in material sciences. The
main focus is on weak-strong stability properties of some curvature driven interface
evolution problems, such as the two-phase Navier–Stokes flow with surface tension
and multiphase mean curvature flow, and on the phase-field approximation of the
latter. Furthermore, we discuss a variational approach to the study of a class
of doubly nonlinear wave equations.\r\nFirst, we consider the two-phase Navier–Stokes
flow with surface tension within a bounded domain. The two fluids are immiscible
and separated by a sharp interface, which intersects the boundary of the domain
at a constant contact angle of ninety degree. We devise a suitable concept of
varifolds solutions for the associated interface evolution problem and we establish
a weak-strong uniqueness principle in case of a two dimensional ambient space.
In order to focus on the boundary effects and on the singular geometry of the
evolving domains, we work for simplicity in the regime of same viscosities for
the two fluids.\r\nThe core of the thesis consists in the rigorous proof of the
convergence of the vectorial Allen-Cahn equation towards multiphase mean curvature
flow for a suitable class of multi- well potentials and for well-prepared initial
data. We even establish a rate of convergence. Our relative energy approach relies
on the concept of gradient-flow calibration for branching singularities in multiphase
mean curvature flow and thus enables us to overcome the limitations of other approaches.
To the best of the author’s knowledge, our result is the first quantitative and
unconditional one available in the literature for the vectorial/multiphase setting.\r\nThis
thesis also contains a first study of weak-strong stability for planar multiphase
mean curvature flow beyond the singularity resulting from a topology change. Previous
weak-strong results are indeed limited to time horizons before the first topology
change of the strong solution. We consider circular topology changes and we prove
weak-strong stability for BV solutions to planar multiphase mean curvature flow
beyond the associated singular times by dynamically adapting the strong solutions
to the weak one by means of a space-time shift.\r\nIn the context of interface
evolution problems, our proofs for the main results of this thesis are based on
the relative energy technique, relying on novel suitable notions of relative energy
functionals, which in particular measure the interface error. Our statements follow
from the resulting stability estimates for the relative energy associated to the
problem.\r\nAt last, we introduce a variational approach to the study of nonlinear
evolution problems. This approach hinges on the minimization of a parameter dependent
family of convex functionals over entire trajectories, known as Weighted Inertia-Dissipation-Energy
(WIDE) functionals. We consider a class of doubly nonlinear wave equations and
establish the convergence, up to subsequences, of the associated WIDE minimizers
to a solution of the target problem as the parameter goes to zero."
acknowledgement: The research projects contained in this thesis have received funding
from the European Research Council (ERC) under the European Union’s Horizon 2020
research and innovation programme (grant agreement No 948819).
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Alice
full_name: Marveggio, Alice
id: 25647992-AA84-11E9-9D75-8427E6697425
last_name: Marveggio
citation:
ama: Marveggio A. Weak-strong stability and phase-field approximation of interface
evolution problems in fluid mechanics and in material sciences. 2023. doi:10.15479/at:ista:14587
apa: Marveggio, A. (2023). Weak-strong stability and phase-field approximation
of interface evolution problems in fluid mechanics and in material sciences.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14587
chicago: Marveggio, Alice. “Weak-Strong Stability and Phase-Field Approximation
of Interface Evolution Problems in Fluid Mechanics and in Material Sciences.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:14587.
ieee: A. Marveggio, “Weak-strong stability and phase-field approximation of interface
evolution problems in fluid mechanics and in material sciences,” Institute of
Science and Technology Austria, 2023.
ista: Marveggio A. 2023. Weak-strong stability and phase-field approximation of
interface evolution problems in fluid mechanics and in material sciences. Institute
of Science and Technology Austria.
mla: Marveggio, Alice. Weak-Strong Stability and Phase-Field Approximation of
Interface Evolution Problems in Fluid Mechanics and in Material Sciences.
Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:14587.
short: A. Marveggio, Weak-Strong Stability and Phase-Field Approximation of Interface
Evolution Problems in Fluid Mechanics and in Material Sciences, Institute of Science
and Technology Austria, 2023.
date_created: 2023-11-21T11:41:05Z
date_published: 2023-11-21T00:00:00Z
date_updated: 2024-03-22T13:21:28Z
day: '21'
ddc:
- '515'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JuFi
doi: 10.15479/at:ista:14587
ec_funded: 1
file:
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creator: amarvegg
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date_created: 2023-11-29T09:10:19Z
date_updated: 2024-03-20T12:28:32Z
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has_accepted_license: '1'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: '228'
project:
- _id: 0aa76401-070f-11eb-9043-b5bb049fa26d
call_identifier: H2020
grant_number: '948819'
name: Bridging Scales in Random Materials
publication_identifier:
issn:
- 2663 - 337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '11842'
relation: part_of_dissertation
status: public
- id: '14597'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Julian L
full_name: Fischer, Julian L
id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
last_name: Fischer
orcid: 0000-0002-0479-558X
title: Weak-strong stability and phase-field approximation of interface evolution
problems in fluid mechanics and in material sciences
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '15128'
abstract:
- lang: eng
text: "We prove a universal mesoscopic central limit theorem for linear eigenvalue
statistics of a Wigner-type matrix inside the bulk of the spectrum with compactly
supported twice continuously differentiable test functions. The main novel ingredient
is an optimal local law for the two-point function $T(z,\\zeta)$ and a general
class of related quantities involving two resolvents\r\nat nearby spectral parameters. "
acknowledgement: Supported by the ERC Advanced Grant ”RMTBeyond” No. 101020331
article_number: '2301.01712'
article_processing_charge: No
author:
- first_name: Volodymyr
full_name: Riabov, Volodymyr
id: 1949f904-edfb-11eb-afb5-e2dfddabb93b
last_name: Riabov
citation:
ama: Riabov V. Mesoscopic eigenvalue statistics for Wigner-type matrices. arXiv.
doi:10.48550/arXiv.2301.01712
apa: Riabov, V. (n.d.). Mesoscopic eigenvalue statistics for Wigner-type matrices.
arXiv. https://doi.org/10.48550/arXiv.2301.01712
chicago: Riabov, Volodymyr. “Mesoscopic Eigenvalue Statistics for Wigner-Type Matrices.”
ArXiv, n.d. https://doi.org/10.48550/arXiv.2301.01712.
ieee: V. Riabov, “Mesoscopic eigenvalue statistics for Wigner-type matrices,” arXiv.
.
ista: Riabov V. Mesoscopic eigenvalue statistics for Wigner-type matrices. arXiv,
2301.01712.
mla: Riabov, Volodymyr. “Mesoscopic Eigenvalue Statistics for Wigner-Type Matrices.”
ArXiv, 2301.01712, doi:10.48550/arXiv.2301.01712.
short: V. Riabov, ArXiv (n.d.).
date_created: 2024-03-20T09:41:04Z
date_published: 2023-01-04T00:00:00Z
date_updated: 2024-03-25T12:48:20Z
day: '04'
department:
- _id: GradSch
- _id: LaEr
doi: 10.48550/arXiv.2301.01712
ec_funded: 1
external_id:
arxiv:
- '2301.01712'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.48550/arXiv.2301.01712
month: '01'
oa: 1
oa_version: Preprint
project:
- _id: 62796744-2b32-11ec-9570-940b20777f1d
call_identifier: H2020
grant_number: '101020331'
name: Random matrices beyond Wigner-Dyson-Mehta
publication: arXiv
publication_status: submitted
status: public
title: Mesoscopic eigenvalue statistics for Wigner-type matrices
type: preprint
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2023'
...
---
_id: '12491'
abstract:
- lang: eng
text: "The extracellular matrix (ECM) is a hydrated and complex three-dimensional
network consisting of proteins, polysaccharides, and water. It provides structural
scaffolding for the cells embedded within it and is essential in regulating numerous
physiological processes, including cell migration and proliferation, wound healing,
and stem cell fate. \r\nDespite extensive study, detailed structural knowledge
of ECM components in physiologically relevant conditions is still rudimentary.
This is due to methodological limitations in specimen preparation protocols which
are incompatible with keeping large samples, such as the ECM, in their native
state for subsequent imaging. Conventional electron microscopy (EM) techniques
rely on fixation, dehydration, contrasting, and sectioning. This results in the
alteration of a highly hydrated environment and the potential introduction of
artifacts. Other structural biology techniques, such as nuclear magnetic resonance
(NMR) spectroscopy and X-ray crystallography, allow high-resolution analysis of
protein structures but only work on homogenous and purified samples, hence lacking
contextual information. Currently, no approach exists for the ultrastructural
and structural study of extracellular components under native conditions in a
physiological, 3D environment. \r\nIn this thesis, I have developed a workflow
that allows for the ultrastructural analysis of the ECM in near-native conditions
at molecular resolution. The developments I introduced include implementing a
novel specimen preparation workflow for cell-derived matrices (CDMs) to render
them compatible with ion-beam milling and subsequent high-resolution cryo-electron
tomography (ET). \r\nTo this end, I have established protocols to generate CDMs
grown over several weeks on EM grids that are compatible with downstream cryo-EM
sample preparation and imaging techniques. Characterization of these ECMs confirmed
that they contain essential ECM components such as collagen I, collagen VI, and
fibronectin I in high abundance and hence represent a bona fide biologically-relevant
sample. I successfully optimized vitrification of these specimens by testing various
vitrification techniques and cryoprotectants. \r\nIn order to obtain high-resolution
molecular insights into the ultrastructure and organization of CDMs, I established
cryo-focused ion beam scanning electron microscopy (FIBSEM) on these challenging
and complex specimens. I explored different approaches for the creation of thin
cryo-lamellae by FIB milling and succeeded in optimizing the cryo-lift-out technique,
resulting in high-quality lamellae of approximately 200 nm thickness. \r\nHigh-resolution
Cryo-ET of these lamellae revealed for the first time the architecture of native
CDM in the context of matrix-secreting cells. This allowed for the in situ visualization
of fibrillar matrix proteins such as collagen, laying the foundation for future
structural and ultrastructural characterization of these proteins in their near-native
environment. \r\nIn summary, in this thesis, I present a novel workflow that combines
state-of-the-art cryo-EM specimen preparation and imaging technologies to permit
characterization of the ECM, an important tissue component in higher organisms.
This innovative and highly versatile workflow will enable addressing far-reaching
questions on ECM architecture, composition, and reciprocal ECM-cell interactions."
acknowledged_ssus:
- _id: EM-Fac
- _id: LifeSc
- _id: Bio
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Bettina
full_name: Zens, Bettina
id: 45FD126C-F248-11E8-B48F-1D18A9856A87
last_name: Zens
orcid: 0000-0002-9561-1239
citation:
ama: Zens B. Ultrastructural characterization of natively preserved extracellular
matrix by cryo-electron tomography. 2023. doi:10.15479/at:ista:12491
apa: Zens, B. (2023). Ultrastructural characterization of natively preserved
extracellular matrix by cryo-electron tomography. Institute of Science and
Technology Austria. https://doi.org/10.15479/at:ista:12491
chicago: Zens, Bettina. “Ultrastructural Characterization of Natively Preserved
Extracellular Matrix by Cryo-Electron Tomography.” Institute of Science and Technology
Austria, 2023. https://doi.org/10.15479/at:ista:12491.
ieee: B. Zens, “Ultrastructural characterization of natively preserved extracellular
matrix by cryo-electron tomography,” Institute of Science and Technology Austria,
2023.
ista: Zens B. 2023. Ultrastructural characterization of natively preserved extracellular
matrix by cryo-electron tomography. Institute of Science and Technology Austria.
mla: Zens, Bettina. Ultrastructural Characterization of Natively Preserved Extracellular
Matrix by Cryo-Electron Tomography. Institute of Science and Technology Austria,
2023, doi:10.15479/at:ista:12491.
short: B. Zens, Ultrastructural Characterization of Natively Preserved Extracellular
Matrix by Cryo-Electron Tomography, Institute of Science and Technology Austria,
2023.
date_created: 2023-02-02T14:50:20Z
date_published: 2023-02-02T00:00:00Z
date_updated: 2024-03-25T23:30:05Z
day: '02'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: FlSc
doi: 10.15479/at:ista:12491
file:
- access_level: open_access
checksum: 069d87f025e0799bf9e3c375664264f2
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date_updated: 2024-02-08T23:30:04Z
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date_updated: 2024-02-08T23:30:04Z
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file_name: PhDThesis_BettinaZens_2023_final.docx
file_size: 106169509
relation: source_file
file_date_updated: 2024-02-08T23:30:04Z
has_accepted_license: '1'
keyword:
- cryo-EM
- cryo-ET
- FIB milling
- method development
- FIBSEM
- extracellular matrix
- ECM
- cell-derived matrices
- CDMs
- cell culture
- high pressure freezing
- HPF
- structural biology
- tomography
- collagen
language:
- iso: eng
month: '02'
oa: 1
oa_version: Published Version
page: '187'
project:
- _id: eba3b5f6-77a9-11ec-83b8-cf0905748aa3
name: Integrated visual proteomics of reciprocal cell-extracellular matrix interactions
- _id: 059B463C-7A3F-11EA-A408-12923DDC885E
name: NÖ-Fonds Preis für die Jungforscherin des Jahres am IST Austria
publication_identifier:
isbn:
- 978-3-99078-027-5
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8586'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Florian KM
full_name: Schur, Florian KM
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
title: Ultrastructural characterization of natively preserved extracellular matrix
by cryo-electron tomography
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14226'
abstract:
- lang: eng
text: "We introduce the notion of a Faustian interchange in a 1-parameter family
of smooth\r\nfunctions to generalize the medial axis to critical points of index
larger than 0.\r\nWe construct and implement a general purpose algorithm for approximating
such\r\ngeneralized medial axes."
alternative_title:
- ISTA Master's Thesis
article_processing_charge: No
author:
- first_name: Elizabeth R
full_name: Stephenson, Elizabeth R
id: 2D04F932-F248-11E8-B48F-1D18A9856A87
last_name: Stephenson
orcid: 0000-0002-6862-208X
citation:
ama: Stephenson ER. Generalizing medial axes with homology switches. 2023. doi:10.15479/at:ista:14226
apa: Stephenson, E. R. (2023). Generalizing medial axes with homology switches.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14226
chicago: Stephenson, Elizabeth R. “Generalizing Medial Axes with Homology Switches.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:14226.
ieee: E. R. Stephenson, “Generalizing medial axes with homology switches,” Institute
of Science and Technology Austria, 2023.
ista: Stephenson ER. 2023. Generalizing medial axes with homology switches. Institute
of Science and Technology Austria.
mla: Stephenson, Elizabeth R. Generalizing Medial Axes with Homology Switches.
Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:14226.
short: E.R. Stephenson, Generalizing Medial Axes with Homology Switches, Institute
of Science and Technology Austria, 2023.
date_created: 2023-08-24T13:01:18Z
date_published: 2023-08-24T00:00:00Z
date_updated: 2024-02-26T23:30:04Z
day: '24'
ddc:
- '500'
degree_awarded: MS
department:
- _id: GradSch
- _id: HeEd
doi: 10.15479/at:ista:14226
file:
- access_level: closed
checksum: 453caf851d75c3478c10ed09bd242a91
content_type: application/x-zip-compressed
creator: cchlebak
date_created: 2023-08-24T13:02:49Z
date_updated: 2024-02-26T23:30:03Z
embargo_to: open_access
file_id: '14227'
file_name: documents-export-2023-08-24.zip
file_size: 15501411
relation: source_file
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checksum: 7349d29963d6695e555e171748648d9a
content_type: application/pdf
creator: cchlebak
date_created: 2023-08-24T13:03:42Z
date_updated: 2024-02-26T23:30:03Z
embargo: 2024-02-25
file_id: '14228'
file_name: thesis_pdf_a.pdf
file_size: 6854783
relation: main_file
file_date_updated: 2024-02-26T23:30:03Z
has_accepted_license: '1'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
page: '43'
publication_identifier:
issn:
- 2791-4585
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
title: Generalizing medial axes with homology switches
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12470'
abstract:
- lang: eng
text: "The brain is an exceptionally sophisticated organ consisting of billions
of cells and trillions of \r\nconnections that orchestrate our cognition and behavior.
To decode its complex connectivity, it is \r\npivotal to disentangle its intricate
architecture spanning from cm-sized circuits down to tens of \r\nnm-small synapses.\r\nTo
achieve this goal, I developed CATS – Comprehensive Analysis of nervous Tissue
across \r\nScales, a versatile toolbox for obtaining a holistic view of nervous
tissue context with (super\x02resolution) fluorescence microscopy. CATS combines
comprehensive labeling of the extracellular\r\nspace, that is compatible with
chemical fixation, with information on molecular markers, super\x02resolved data
acquisition and machine-learning based data analysis for segmentation and synapse
\r\nidentification.\r\nI used CATS to analyze key features of nervous tissue connectivity,
ranging from whole tissue \r\narchitecture, neuronal in- and output-fields, down
to synapse morphology.\r\nFocusing on the hippocampal circuitry, I quantified
synaptic transmission properties of mossy \r\nfiber boutons and analyzed the connectivity
pattern of dentate gyrus granule cells with CA3 \r\npyramidal neurons. This shows
that CATS is a viable tool to study hallmarks of neuronal \r\nconnectivity with
light microscopy."
acknowledged_ssus:
- _id: Bio
- _id: LifeSc
- _id: PreCl
- _id: EM-Fac
- _id: M-Shop
- _id: ScienComp
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Julia M
full_name: Michalska, Julia M
id: 443DB6DE-F248-11E8-B48F-1D18A9856A87
last_name: Michalska
orcid: 0000-0003-3862-1235
citation:
ama: Michalska JM. A versatile toolbox for the comprehensive analysis of nervous
tissue organization with light microscopy. 2023. doi:10.15479/at:ista:12470
apa: Michalska, J. M. (2023). A versatile toolbox for the comprehensive analysis
of nervous tissue organization with light microscopy. Institute of Science
and Technology Austria. https://doi.org/10.15479/at:ista:12470
chicago: Michalska, Julia M. “A Versatile Toolbox for the Comprehensive Analysis
of Nervous Tissue Organization with Light Microscopy.” Institute of Science and
Technology Austria, 2023. https://doi.org/10.15479/at:ista:12470.
ieee: J. M. Michalska, “A versatile toolbox for the comprehensive analysis of nervous
tissue organization with light microscopy,” Institute of Science and Technology
Austria, 2023.
ista: Michalska JM. 2023. A versatile toolbox for the comprehensive analysis of
nervous tissue organization with light microscopy. Institute of Science and Technology
Austria.
mla: Michalska, Julia M. A Versatile Toolbox for the Comprehensive Analysis of
Nervous Tissue Organization with Light Microscopy. Institute of Science and
Technology Austria, 2023, doi:10.15479/at:ista:12470.
short: J.M. Michalska, A Versatile Toolbox for the Comprehensive Analysis of Nervous
Tissue Organization with Light Microscopy, Institute of Science and Technology
Austria, 2023.
date_created: 2023-01-31T15:10:53Z
date_published: 2023-01-09T00:00:00Z
date_updated: 2023-08-31T12:26:58Z
day: '09'
ddc:
- '610'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JoDa
doi: 10.15479/at:ista:12470
ec_funded: 1
file:
- access_level: open_access
checksum: 1a2306e5f59f52df598e7ecfadf921ac
content_type: application/pdf
creator: cchlebak
date_created: 2023-01-31T15:11:42Z
date_updated: 2023-07-27T22:30:54Z
embargo: 2023-07-09
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file_size: 41771714
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creator: cchlebak
date_created: 2023-01-31T15:11:51Z
date_updated: 2023-07-10T22:30:04Z
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file_name: 20230109_PhD_thesis_JM_final.docx
file_size: 66983464
relation: source_file
file_date_updated: 2023-07-27T22:30:54Z
has_accepted_license: '1'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Published Version
page: '201'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
- _id: 26AA4EF2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: W1232-B24
name: Molecular Drug Targets
publication_identifier:
isbn:
- ' 978-3-99078-026-8'
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '11943'
relation: part_of_dissertation
status: public
- id: '11950'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Johann G
full_name: Danzl, Johann G
id: 42EFD3B6-F248-11E8-B48F-1D18A9856A87
last_name: Danzl
orcid: 0000-0001-8559-3973
title: A versatile toolbox for the comprehensive analysis of nervous tissue organization
with light microscopy
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12531'
abstract:
- lang: eng
text: "All visual experiences of the vertebrates begin with light being converted
into electrical signals\r\nby the eye retina. Retinal ganglion cells (RGCs) are
the neurons of the innermost layer of the\r\nmammal retina, and they transmit
visual information to the rest of the brain.\r\nIt has been shown that RGCs vary
in their morphology and genetic profiles, moreover they can\r\nbe unambiguously
grouped into subtypes that share the same morphological and/or molecular\r\nproperties.
However, in terms of RGCs function, it remains unclear how many distinct types\r\nthere
are and what response properties their typology relies on. Even given the recent
studies\r\nthat successfully classified RGCs in a patch of the retina [1] and
in scotopic conditions [2], the\r\nquestion remains whether the found subtypes
persist across the entire retina.\r\nIn this work, using a novel imaging method,
we show that, when sampled from a large portion\r\nof the retina, RGCs can not
be clearly divided into functional subtypes. We found that in\r\nphotopic conditions,
which implies more prominent natural scene statistic differences across\r\nthe
visual field, response properties can be exhibited by cells differently depending
on their\r\nlocation in the retina, which leads to formation of a gradient of
features rather than distinct\r\nclasses.\r\nThis finding suggests that RGCs follow
a global organization across the visual field of the\r\nanimal, adapting each
RGC subtype to the requirements imposed by the natural scene statistics."
alternative_title:
- ISTA Master's Thesis
article_processing_charge: No
author:
- first_name: Kseniia
full_name: Kirillova, Kseniia
id: 8e3f931e-dc85-11ea-9058-e7b957bf23f0
last_name: Kirillova
citation:
ama: Kirillova K. Panoramic functional gradients across the mouse retina. 2023.
doi:10.15479/at:ista:12531
apa: Kirillova, K. (2023). Panoramic functional gradients across the mouse retina.
Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12531
chicago: Kirillova, Kseniia. “Panoramic Functional Gradients across the Mouse Retina.”
Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:12531.
ieee: K. Kirillova, “Panoramic functional gradients across the mouse retina,” Institute
of Science and Technology Austria, 2023.
ista: Kirillova K. 2023. Panoramic functional gradients across the mouse retina.
Institute of Science and Technology Austria.
mla: Kirillova, Kseniia. Panoramic Functional Gradients across the Mouse Retina.
Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:12531.
short: K. Kirillova, Panoramic Functional Gradients across the Mouse Retina, Institute
of Science and Technology Austria, 2023.
date_created: 2023-02-09T07:45:05Z
date_published: 2023-02-08T00:00:00Z
date_updated: 2024-02-09T23:30:04Z
day: '08'
ddc:
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degree_awarded: MS
department:
- _id: GradSch
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doi: 10.15479/at:ista:12531
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- iso: eng
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oa_version: Published Version
page: '46'
publication_identifier:
issn:
- 2791-4585
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Maximilian A
full_name: Jösch, Maximilian A
id: 2BD278E6-F248-11E8-B48F-1D18A9856A87
last_name: Jösch
orcid: 0000-0002-3937-1330
title: Panoramic functional gradients across the mouse retina
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2023'
...
---
_id: '12800'
abstract:
- lang: eng
text: 'The evolutionary processes that brought about today’s plethora of living
species and the many billions more ancient ones all underlie biology. Evolutionary
pathways are neither directed nor deterministic, but rather an interplay between
selection, migration, mutation, genetic drift and other environmental factors.
Hybrid zones, as natural crossing experiments, offer a great opportunity to use
cline analysis to deduce different evolutionary processes - for example, selection
strength. Theoretical cline models, largely assuming uniform distribution of individuals,
often lack the capability of incorporating population structure. Since in reality
organisms mostly live in patchy distributions and their dispersal is hardly ever
Gaussian, it is necessary to unravel the effect of these different elements of
population structure on cline parameters and shape. In this thesis, I develop
a simulation inspired by the A. majus hybrid zone of a single selected locus under
frequency dependent selection. This simulation enables us to untangle the effects
of different elements of population structure as for example a low-density center
and long-range dispersal. This thesis is therefore a first step towards theoretically
untangling the effects of different elements of population structure on cline
parameters and shape. '
alternative_title:
- ISTA Master's Thesis
article_processing_charge: No
author:
- first_name: Mara
full_name: Julseth, Mara
id: 1cf464b2-dc7d-11ea-9b2f-f9b1aa9417d1
last_name: Julseth
citation:
ama: Julseth M. The effect of local population structure on genetic variation at
selected loci in the A. majus hybrid zone. 2023. doi:10.15479/at:ista:12800
apa: Julseth, M. (2023). The effect of local population structure on genetic
variation at selected loci in the A. majus hybrid zone. Institute of Science
and Technology Austria. https://doi.org/10.15479/at:ista:12800
chicago: Julseth, Mara. “The Effect of Local Population Structure on Genetic Variation
at Selected Loci in the A. Majus Hybrid Zone.” Institute of Science and Technology
Austria, 2023. https://doi.org/10.15479/at:ista:12800.
ieee: M. Julseth, “The effect of local population structure on genetic variation
at selected loci in the A. majus hybrid zone,” Institute of Science and Technology
Austria, 2023.
ista: Julseth M. 2023. The effect of local population structure on genetic variation
at selected loci in the A. majus hybrid zone. Institute of Science and Technology
Austria.
mla: Julseth, Mara. The Effect of Local Population Structure on Genetic Variation
at Selected Loci in the A. Majus Hybrid Zone. Institute of Science and Technology
Austria, 2023, doi:10.15479/at:ista:12800.
short: M. Julseth, The Effect of Local Population Structure on Genetic Variation
at Selected Loci in the A. Majus Hybrid Zone, Institute of Science and Technology
Austria, 2023.
date_created: 2023-04-04T18:57:11Z
date_published: 2023-04-05T00:00:00Z
date_updated: 2023-06-02T22:30:05Z
day: '05'
ddc:
- '576'
degree_awarded: MS
department:
- _id: GradSch
- _id: NiBa
doi: 10.15479/at:ista:12800
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date_updated: 2023-06-02T22:30:04Z
embargo: 2023-06-01
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file_name: ThesisMaraJulseth_04_23.pdf
file_size: 1741364
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file_date_updated: 2023-06-02T22:30:04Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: '21'
publication_identifier:
issn:
- 2791-4585
publication_status: published
publisher: Institute of Science and Technology Austria
status: public
supervisor:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
title: The effect of local population structure on genetic variation at selected loci
in the A. majus hybrid zone
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '14510'
acknowledged_ssus:
- _id: EM-Fac
- _id: Bio
- _id: LifeSc
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Nataliia
full_name: Gnyliukh, Nataliia
id: 390C1120-F248-11E8-B48F-1D18A9856A87
last_name: Gnyliukh
orcid: 0000-0002-2198-0509
citation:
ama: Gnyliukh N. Mechanism of clathrin-coated vesicle formation during endocytosis
in plants. 2023. doi:10.15479/at:ista:14510
apa: Gnyliukh, N. (2023). Mechanism of clathrin-coated vesicle formation during
endocytosis in plants. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:14510
chicago: Gnyliukh, Nataliia. “Mechanism of Clathrin-Coated Vesicle Formation during
Endocytosis in Plants.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:14510.
ieee: N. Gnyliukh, “Mechanism of clathrin-coated vesicle formation during endocytosis
in plants,” Institute of Science and Technology Austria, 2023.
ista: Gnyliukh N. 2023. Mechanism of clathrin-coated vesicle formation during endocytosis
in plants. Institute of Science and Technology Austria.
mla: Gnyliukh, Nataliia. Mechanism of Clathrin-Coated Vesicle Formation during
Endocytosis in Plants. Institute of Science and Technology Austria, 2023,
doi:10.15479/at:ista:14510.
short: N. Gnyliukh, Mechanism of Clathrin-Coated Vesicle Formation during Endocytosis
in Plants, Institute of Science and Technology Austria, 2023.
date_created: 2023-11-10T09:10:06Z
date_published: 2023-11-10T00:00:00Z
date_updated: 2024-03-27T23:30:45Z
day: '10'
ddc:
- '570'
degree_awarded: PhD
department:
- _id: GradSch
- _id: JiFr
- _id: MaLo
doi: 10.15479/at:ista:14510
ec_funded: 1
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creator: ngnyliuk
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date_updated: 2023-11-20T09:18:51Z
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file_size: 20824903
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creator: ngnyliuk
date_created: 2023-11-20T09:23:11Z
date_updated: 2023-11-23T13:10:55Z
embargo: 2024-11-23
embargo_to: open_access
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file_name: Thesis_Gnyliukh_final_20_11_23.pdf
file_size: 24871844
relation: main_file
file_date_updated: 2023-11-23T13:10:55Z
has_accepted_license: '1'
keyword:
- Clathrin-Mediated Endocytosis
- vesicle scission
- Dynamin-Related Protein 2
- SH3P2
- TPLATE complex
- Total internal reflection fluorescence microscopy
- Arabidopsis thaliana
language:
- iso: eng
month: '11'
oa_version: Published Version
page: '180'
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication_identifier:
isbn:
- 978-3-99078-037-4
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '14591'
relation: part_of_dissertation
status: public
- id: '9887'
relation: part_of_dissertation
status: public
- id: '8139'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Jiří
full_name: Friml, Jiří
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Martin
full_name: Loose, Martin
id: 462D4284-F248-11E8-B48F-1D18A9856A87
last_name: Loose
orcid: 0000-0001-7309-9724
title: Mechanism of clathrin-coated vesicle formation during endocytosis in plants
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: dissertation
user_id: 8b945eb4-e2f2-11eb-945a-df72226e66a9
year: '2023'
...
---
_id: '12897'
abstract:
- lang: eng
text: "Inverse design problems in fabrication-aware shape optimization are typically
solved on discrete representations such as polygonal meshes. This thesis argues
that there are benefits to treating these problems in the same domain as human
designers, namely, the parametric one. One reason is that discretizing a parametric
model usually removes the capability of making further manual changes to the design,
because the human intent is captured by the shape parameters. Beyond this, knowledge
about a design problem can sometimes reveal a structure that is present in a smooth
representation, but is fundamentally altered by discretizing. In this case, working
in the parametric domain may even simplify the optimization task. We present two
lines of research that explore both of these aspects of fabrication-aware shape
optimization on parametric representations.\r\n\r\nThe first project studies the
design of plane elastic curves and Kirchhoff rods, which are common mathematical
models for describing the deformation of thin elastic rods such as beams, ribbons,
cables, and hair. Our main contribution is a characterization of all curved shapes
that can be attained by bending and twisting elastic rods having a stiffness that
is allowed to vary across the length. Elements like these can be manufactured
using digital fabrication devices such as 3d printers and digital cutters, and
have applications in free-form architecture and soft robotics.\r\n\r\nWe show
that the family of curved shapes that can be produced this way admits geometric
description that is concise and computationally convenient. In the case of plane
curves, the geometric description is intuitive enough to allow a designer to determine
whether a curved shape is physically achievable by visual inspection alone. We
also present shape optimization algorithms that convert a user-defined curve in
the plane or in three dimensions into the geometry of an elastic rod that will
naturally deform to follow this curve when its endpoints are attached to a support
structure. Implemented in an interactive software design tool, the rod geometry
is generated in real time as the user edits a curve and enables fast prototyping.
\r\n\r\nThe second project tackles the problem of general-purpose shape optimization
on CAD models using a novel variant of the extended finite element method (XFEM).
Our goal is the decoupling between the simulation mesh and the CAD model, so no
geometry-dependent meshing or remeshing needs to be performed when the CAD parameters
change during optimization. This is achieved by discretizing the embedding space
of the CAD model, and using a new high-accuracy numerical integration method to
enable XFEM on free-form elements bounded by the parametric surface patches of
the model. Our simulation is differentiable from the CAD parameters to the simulation
output, which enables us to use off-the-shelf gradient-based optimization procedures.
The result is a method that fits seamlessly into the CAD workflow because it works
on the same representation as the designer, enabling the alternation of manual
editing and fabrication-aware optimization at will."
acknowledged_ssus:
- _id: M-Shop
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Christian
full_name: Hafner, Christian
id: 400429CC-F248-11E8-B48F-1D18A9856A87
last_name: Hafner
citation:
ama: 'Hafner C. Inverse shape design with parametric representations: Kirchhoff
Rods and parametric surface models. 2023. doi:10.15479/at:ista:12897'
apa: 'Hafner, C. (2023). Inverse shape design with parametric representations:
Kirchhoff Rods and parametric surface models. Institute of Science and Technology
Austria. https://doi.org/10.15479/at:ista:12897'
chicago: 'Hafner, Christian. “Inverse Shape Design with Parametric Representations:
Kirchhoff Rods and Parametric Surface Models.” Institute of Science and Technology
Austria, 2023. https://doi.org/10.15479/at:ista:12897.'
ieee: 'C. Hafner, “Inverse shape design with parametric representations: Kirchhoff
Rods and parametric surface models,” Institute of Science and Technology Austria,
2023.'
ista: 'Hafner C. 2023. Inverse shape design with parametric representations: Kirchhoff
Rods and parametric surface models. Institute of Science and Technology Austria.'
mla: 'Hafner, Christian. Inverse Shape Design with Parametric Representations:
Kirchhoff Rods and Parametric Surface Models. Institute of Science and Technology
Austria, 2023, doi:10.15479/at:ista:12897.'
short: 'C. Hafner, Inverse Shape Design with Parametric Representations: Kirchhoff
Rods and Parametric Surface Models, Institute of Science and Technology Austria,
2023.'
date_created: 2023-05-05T10:40:14Z
date_published: 2023-05-05T00:00:00Z
date_updated: 2024-01-29T10:47:51Z
day: '05'
ddc:
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- '004'
- '518'
- '531'
degree_awarded: PhD
department:
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- _id: BeBi
doi: 10.15479/at:ista:12897
ec_funded: 1
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language:
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oa: 1
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page: '180'
project:
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call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publication_identifier:
isbn:
- 978-3-99078-031-2
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
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status: public
supervisor:
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
title: 'Inverse shape design with parametric representations: Kirchhoff Rods and parametric
surface models'
type: dissertation
user_id: 400429CC-F248-11E8-B48F-1D18A9856A87
year: '2023'
...