---
_id: '617'
abstract:
- lang: eng
text: Insects are exposed to a variety of potential pathogens in their environment,
many of which can severely impact fitness and health. Consequently, hosts have
evolved resistance and tolerance strategies to suppress or cope with infections.
Hosts utilizing resistance improve fitness by clearing or reducing pathogen loads,
and hosts utilizing tolerance reduce harmful fitness effects per pathogen load.
To understand variation in, and selective pressures on, resistance and tolerance,
we asked to what degree they are shaped by host genetic background, whether plasticity
in these responses depends upon dietary environment, and whether there are interactions
between these two factors. Females from ten wild-type Drosophila melanogaster
genotypes were kept on high- or low-protein (yeast) diets and infected with one
of two opportunistic bacterial pathogens, Lactococcus lactis or Pseudomonas entomophila.
We measured host resistance as the inverse of bacterial load in the early infection
phase. The relationship (slope) between fly fecundity and individual-level bacteria
load provided our fecundity tolerance measure. Genotype and dietary yeast determined
host fecundity and strongly affected survival after infection with pathogenic
P. entomophila. There was considerable genetic variation in host resistance, a
commonly found phenomenon resulting from for example varying resistance costs
or frequency-dependent selection. Despite this variation and the reproductive
cost of higher P. entomophila loads, fecundity tolerance did not vary across genotypes.
The absence of genetic variation in tolerance may suggest that at this early infection
stage, fecundity tolerance is fixed or that any evolved tolerance mechanisms are
not expressed under these infection conditions.
acknowledgement: 'We would like to thank Susann Wicke for performing the genome-wide
SNP/indel analyses, as well as Veronica Alves, Kevin Ferro, Momir Futo, Barbara
Hasert, Dafne Maximo, Nora Schulz, Marlene Sroka, and Barth Wieczorek for technical
help. We thank Brian Lazzaro for the L. lactis strain and Bruno Lemaitre for the
Pseudomonas entomophila strain. We would like to thank two anonymous reviewers for
their helpful comments. We are grateful to the Deutsche Forschungsgemeinschaft (DFG)
priority programme 1399 ‘Host parasite coevolution’ for funding this project (AR
872/1-1). '
article_processing_charge: No
article_type: original
author:
- first_name: Megan
full_name: Kutzer, Megan
id: 29D0B332-F248-11E8-B48F-1D18A9856A87
last_name: Kutzer
orcid: 0000-0002-8696-6978
- first_name: Joachim
full_name: Kurtz, Joachim
last_name: Kurtz
- first_name: Sophie
full_name: Armitage, Sophie
last_name: Armitage
citation:
ama: Kutzer M, Kurtz J, Armitage S. Genotype and diet affect resistance, survival,
and fecundity but not fecundity tolerance. Journal of Evolutionary Biology.
2018;31(1):159-171. doi:10.1111/jeb.13211
apa: Kutzer, M., Kurtz, J., & Armitage, S. (2018). Genotype and diet affect
resistance, survival, and fecundity but not fecundity tolerance. Journal of
Evolutionary Biology. Wiley. https://doi.org/10.1111/jeb.13211
chicago: Kutzer, Megan, Joachim Kurtz, and Sophie Armitage. “Genotype and Diet Affect
Resistance, Survival, and Fecundity but Not Fecundity Tolerance.” Journal of
Evolutionary Biology. Wiley, 2018. https://doi.org/10.1111/jeb.13211.
ieee: M. Kutzer, J. Kurtz, and S. Armitage, “Genotype and diet affect resistance,
survival, and fecundity but not fecundity tolerance,” Journal of Evolutionary
Biology, vol. 31, no. 1. Wiley, pp. 159–171, 2018.
ista: Kutzer M, Kurtz J, Armitage S. 2018. Genotype and diet affect resistance,
survival, and fecundity but not fecundity tolerance. Journal of Evolutionary Biology.
31(1), 159–171.
mla: Kutzer, Megan, et al. “Genotype and Diet Affect Resistance, Survival, and Fecundity
but Not Fecundity Tolerance.” Journal of Evolutionary Biology, vol. 31,
no. 1, Wiley, 2018, pp. 159–71, doi:10.1111/jeb.13211.
short: M. Kutzer, J. Kurtz, S. Armitage, Journal of Evolutionary Biology 31 (2018)
159–171.
date_created: 2018-12-11T11:47:31Z
date_published: 2018-01-01T00:00:00Z
date_updated: 2023-09-11T14:06:04Z
day: '01'
department:
- _id: SyCr
doi: 10.1111/jeb.13211
external_id:
isi:
- '000419307000014'
pmid:
- '29150962'
intvolume: ' 31'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1111/jeb.13211
month: '01'
oa: 1
oa_version: Published Version
page: 159 - 171
pmid: 1
publication: Journal of Evolutionary Biology
publication_identifier:
eissn:
- 1420-9101
issn:
- 1010-061X
publication_status: published
publisher: Wiley
publist_id: '7187'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Genotype and diet affect resistance, survival, and fecundity but not fecundity
tolerance
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 31
year: '2018'
...
---
_id: '426'
abstract:
- lang: eng
text: Sperm cells are the most morphologically diverse cells across animal taxa.
Within species, sperm and ejaculate traits have been suggested to vary with the
male's competitive environment, e.g., level of sperm competition, female mating
status and quality, and also with male age, body mass, physiological condition,
and resource availability. Most previous studies have based their conclusions
on the analysis of only one or a few ejaculates per male without investigating
differences among the ejaculates of the same individual. This masks potential
ejaculate-specific traits. Here, we provide data on the length, quantity, and
viability of sperm ejaculated by wingless males of the ant Cardiocondyla obscurior.
Males of this ant species are relatively long-lived and can mate with large numbers
of female sexuals throughout their lives. We analyzed all ejaculates across the
individuals' lifespan and manipulated the availability of mating partners. Our
study shows that both the number and size of sperm cells transferred during copulations
differ among individuals and also among ejaculates of the same male. Sperm quality
does not decrease with male age, but the variation in sperm number between ejaculates
indicates that males need considerable time to replenish their sperm supplies.
Producing many ejaculates in a short time appears to be traded-off against male
longevity rather than sperm quality.
acknowledgement: "Research with C. obscurior from Brazil was permitted by Instituto
Brasileiro do Meio Ambiente e dos Recursos Naturais Renováveis, IBAMA (permit no.
20324-1). We thank the German Science Foundation ( DFG ) for funding ( Schr1135/2-1
), T. Suckert for help with sperm length measurements and A.K. Huylmans for advice
concerning graphs. One referee made helpful comments on the manuscript.\r\n"
article_processing_charge: No
author:
- first_name: Sina
full_name: Metzler, Sina
id: 48204546-F248-11E8-B48F-1D18A9856A87
last_name: Metzler
orcid: 0000-0002-9547-2494
- first_name: Alexandra
full_name: Schrempf, Alexandra
last_name: Schrempf
- first_name: Jürgen
full_name: Heinze, Jürgen
last_name: Heinze
citation:
ama: Metzler S, Schrempf A, Heinze J. Individual- and ejaculate-specific sperm traits
in ant males. Journal of Insect Physiology. 2018;107:284-290. doi:10.1016/j.jinsphys.2017.12.003
apa: Metzler, S., Schrempf, A., & Heinze, J. (2018). Individual- and ejaculate-specific
sperm traits in ant males. Journal of Insect Physiology. Elsevier. https://doi.org/10.1016/j.jinsphys.2017.12.003
chicago: Metzler, Sina, Alexandra Schrempf, and Jürgen Heinze. “Individual- and
Ejaculate-Specific Sperm Traits in Ant Males.” Journal of Insect Physiology.
Elsevier, 2018. https://doi.org/10.1016/j.jinsphys.2017.12.003.
ieee: S. Metzler, A. Schrempf, and J. Heinze, “Individual- and ejaculate-specific
sperm traits in ant males,” Journal of Insect Physiology, vol. 107. Elsevier,
pp. 284–290, 2018.
ista: Metzler S, Schrempf A, Heinze J. 2018. Individual- and ejaculate-specific
sperm traits in ant males. Journal of Insect Physiology. 107, 284–290.
mla: Metzler, Sina, et al. “Individual- and Ejaculate-Specific Sperm Traits in Ant
Males.” Journal of Insect Physiology, vol. 107, Elsevier, 2018, pp. 284–90,
doi:10.1016/j.jinsphys.2017.12.003.
short: S. Metzler, A. Schrempf, J. Heinze, Journal of Insect Physiology 107 (2018)
284–290.
date_created: 2018-12-11T11:46:25Z
date_published: 2018-05-01T00:00:00Z
date_updated: 2023-09-12T07:43:26Z
day: '01'
department:
- _id: SyCr
doi: 10.1016/j.jinsphys.2017.12.003
external_id:
isi:
- '000434751100034'
intvolume: ' 107'
isi: 1
language:
- iso: eng
month: '05'
oa_version: None
page: 284-290
publication: Journal of Insect Physiology
publication_status: published
publisher: Elsevier
publist_id: '7397'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Individual- and ejaculate-specific sperm traits in ant males
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 107
year: '2018'
...
---
_id: '194'
abstract:
- lang: eng
text: Ants are emerging model systems to study cellular signaling because distinct
castes possess different physiologic phenotypes within the same colony. Here we
studied the functionality of inotocin signaling, an insect ortholog of mammalian
oxytocin (OT), which was recently discovered in ants. In Lasius ants, we determined
that specialization within the colony, seasonal factors, and physiologic conditions
down-regulated the expression of the OT-like signaling system. Given this natural
variation, we interrogated its function using RNAi knockdowns. Next-generation
RNA sequencing of OT-like precursor knock-down ants highlighted its role in the
regulation of genes involved in metabolism. Knock-down ants exhibited higher walking
activity and increased self-grooming in the brood chamber. We propose that OT-like
signaling in ants is important for regulating metabolic processes and locomotion.
article_processing_charge: No
article_type: original
author:
- first_name: Zita
full_name: Liutkeviciute, Zita
last_name: Liutkeviciute
- first_name: Esther
full_name: Gil Mansilla, Esther
last_name: Gil Mansilla
- first_name: Thomas
full_name: Eder, Thomas
last_name: Eder
- first_name: Barbara E
full_name: Casillas Perez, Barbara E
id: 351ED2AA-F248-11E8-B48F-1D18A9856A87
last_name: Casillas Perez
- first_name: Maria
full_name: Giulia Di Giglio, Maria
last_name: Giulia Di Giglio
- first_name: Edin
full_name: Muratspahić, Edin
last_name: Muratspahić
- first_name: Florian
full_name: Grebien, Florian
last_name: Grebien
- first_name: Thomas
full_name: Rattei, Thomas
last_name: Rattei
- first_name: Markus
full_name: Muttenthaler, Markus
last_name: Muttenthaler
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Christian
full_name: Gruber, Christian
last_name: Gruber
citation:
ama: Liutkeviciute Z, Gil Mansilla E, Eder T, et al. Oxytocin-like signaling in
ants influences metabolic gene expression and locomotor activity. The FASEB
Journal. 2018;32(12):6808-6821. doi:10.1096/fj.201800443
apa: Liutkeviciute, Z., Gil Mansilla, E., Eder, T., Casillas Perez, B. E., Giulia
Di Giglio, M., Muratspahić, E., … Gruber, C. (2018). Oxytocin-like signaling in
ants influences metabolic gene expression and locomotor activity. The FASEB
Journal. FASEB. https://doi.org/10.1096/fj.201800443
chicago: Liutkeviciute, Zita, Esther Gil Mansilla, Thomas Eder, Barbara E Casillas
Perez, Maria Giulia Di Giglio, Edin Muratspahić, Florian Grebien, et al. “Oxytocin-like
Signaling in Ants Influences Metabolic Gene Expression and Locomotor Activity.”
The FASEB Journal. FASEB, 2018. https://doi.org/10.1096/fj.201800443.
ieee: Z. Liutkeviciute et al., “Oxytocin-like signaling in ants influences
metabolic gene expression and locomotor activity,” The FASEB Journal, vol.
32, no. 12. FASEB, pp. 6808–6821, 2018.
ista: Liutkeviciute Z, Gil Mansilla E, Eder T, Casillas Perez BE, Giulia Di Giglio
M, Muratspahić E, Grebien F, Rattei T, Muttenthaler M, Cremer S, Gruber C. 2018.
Oxytocin-like signaling in ants influences metabolic gene expression and locomotor
activity. The FASEB Journal. 32(12), 6808–6821.
mla: Liutkeviciute, Zita, et al. “Oxytocin-like Signaling in Ants Influences Metabolic
Gene Expression and Locomotor Activity.” The FASEB Journal, vol. 32, no.
12, FASEB, 2018, pp. 6808–21, doi:10.1096/fj.201800443.
short: Z. Liutkeviciute, E. Gil Mansilla, T. Eder, B.E. Casillas Perez, M. Giulia
Di Giglio, E. Muratspahić, F. Grebien, T. Rattei, M. Muttenthaler, S. Cremer,
C. Gruber, The FASEB Journal 32 (2018) 6808–6821.
date_created: 2018-12-11T11:45:08Z
date_published: 2018-11-29T00:00:00Z
date_updated: 2023-09-13T09:37:32Z
day: '29'
department:
- _id: SyCr
doi: 10.1096/fj.201800443
external_id:
isi:
- '000449359700035'
pmid:
- '29939785'
intvolume: ' 32'
isi: 1
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: ' https://doi.org/10.1096/fj.201800443'
month: '11'
oa: 1
oa_version: Published Version
page: 6808-6821
pmid: 1
project:
- _id: 25E3D34E-B435-11E9-9278-68D0E5697425
name: Individual function and social role of oxytocin-like neuropeptides in ants
publication: The FASEB Journal
publication_identifier:
issn:
- '08926638'
publication_status: published
publisher: FASEB
publist_id: '7721'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Oxytocin-like signaling in ants influences metabolic gene expression and locomotor
activity
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 32
year: '2018'
...
---
_id: '55'
abstract:
- lang: eng
text: Many animals use antimicrobials to prevent or cure disease [1,2]. For example,
some animals will ingest plants with medicinal properties, both prophylactically
to prevent infection and therapeutically to self-medicate when sick. Antimicrobial
substances are also used as topical disinfectants, to prevent infection, protect
offspring and to sanitise their surroundings [1,2]. Social insects (ants, bees,
wasps and termites) build nests in environments with a high abundance and diversity
of pathogenic microorganisms — such as soil and rotting wood — and colonies are
often densely crowded, creating conditions that favour disease outbreaks. Consequently,
social insects have evolved collective disease defences to protect their colonies
from epidemics. These traits can be seen as functionally analogous to the immune
system of individual organisms [3,4]. This ‘social immunity’ utilises antimicrobials
to prevent and eradicate infections, and to keep the brood and nest clean. However,
these antimicrobial compounds can be harmful to the insects themselves, and it
is unknown how colonies prevent collateral damage when using them. Here, we demonstrate
that antimicrobial acids, produced by workers to disinfect the colony, are harmful
to the delicate pupal brood stage, but that the pupae are protected from the acids
by the presence of a silk cocoon. Garden ants spray their nests with an antimicrobial
poison to sanitize contaminated nestmates and brood. Here, Pull et al show that
they also prophylactically sanitise their colonies, and that the silk cocoon serves
as a barrier to protect developing pupae, thus preventing collateral damage during
nest sanitation.
article_processing_charge: No
article_type: original
author:
- first_name: Christopher
full_name: Pull, Christopher
id: 3C7F4840-F248-11E8-B48F-1D18A9856A87
last_name: Pull
orcid: 0000-0003-1122-3982
- first_name: Sina
full_name: Metzler, Sina
id: 48204546-F248-11E8-B48F-1D18A9856A87
last_name: Metzler
orcid: 0000-0002-9547-2494
- first_name: Elisabeth
full_name: Naderlinger, Elisabeth
id: 31757262-F248-11E8-B48F-1D18A9856A87
last_name: Naderlinger
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Pull C, Metzler S, Naderlinger E, Cremer S. Protection against the lethal side
effects of social immunity in ants. Current Biology. 2018;28(19):R1139-R1140.
doi:10.1016/j.cub.2018.08.063
apa: Pull, C., Metzler, S., Naderlinger, E., & Cremer, S. (2018). Protection
against the lethal side effects of social immunity in ants. Current Biology.
Cell Press. https://doi.org/10.1016/j.cub.2018.08.063
chicago: Pull, Christopher, Sina Metzler, Elisabeth Naderlinger, and Sylvia Cremer.
“Protection against the Lethal Side Effects of Social Immunity in Ants.” Current
Biology. Cell Press, 2018. https://doi.org/10.1016/j.cub.2018.08.063.
ieee: C. Pull, S. Metzler, E. Naderlinger, and S. Cremer, “Protection against the
lethal side effects of social immunity in ants,” Current Biology, vol.
28, no. 19. Cell Press, pp. R1139–R1140, 2018.
ista: Pull C, Metzler S, Naderlinger E, Cremer S. 2018. Protection against the lethal
side effects of social immunity in ants. Current Biology. 28(19), R1139–R1140.
mla: Pull, Christopher, et al. “Protection against the Lethal Side Effects of Social
Immunity in Ants.” Current Biology, vol. 28, no. 19, Cell Press, 2018,
pp. R1139–40, doi:10.1016/j.cub.2018.08.063.
short: C. Pull, S. Metzler, E. Naderlinger, S. Cremer, Current Biology 28 (2018)
R1139–R1140.
date_created: 2018-12-11T11:44:23Z
date_published: 2018-10-08T00:00:00Z
date_updated: 2023-09-15T12:06:46Z
day: '08'
department:
- _id: SyCr
doi: 10.1016/j.cub.2018.08.063
external_id:
isi:
- '000446693400008'
intvolume: ' 28'
isi: 1
issue: '19'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cub.2018.08.063
month: '10'
oa: 1
oa_version: Published Version
page: R1139 - R1140
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '7999'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Protection against the lethal side effects of social immunity in ants
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 28
year: '2018'
...
---
_id: '29'
abstract:
- lang: eng
text: Social insects have evolved enormous capacities to collectively build nests
and defend their colonies against both predators and pathogens. The latter is
achieved by a combination of individual immune responses and sophisticated collective
behavioral and organizational disease defenses, that is, social immunity. We investigated
how the presence or absence of these social defense lines affects individual-level
immunity in ant queens after bacterial infection. To this end, we injected queens
of the ant Linepithema humile with a mix of gram+ and gram− bacteria or a control
solution, reared them either with workers or alone and analyzed their gene expression
patterns at 2, 4, 8, and 12 hr post-injection, using RNA-seq. This allowed us
to test for the effect of bacterial infection, social context, as well as the
interaction between the two over the course of infection and raising of an immune
response. We found that social isolation per se affected queen gene expression
for metabolism genes, but not for immune genes. When infected, queens reared with
and without workers up-regulated similar numbers of innate immune genes revealing
activation of Toll and Imd signaling pathways and melanization. Interestingly,
however, they mostly regulated different genes along the pathways and showed a
different pattern of overall gene up-regulation or down-regulation. Hence, we
can conclude that the absence of workers does not compromise the onset of an individual
immune response by the queens, but that the social environment impacts the route
of the individual innate immune responses.
article_processing_charge: No
author:
- first_name: Lumi
full_name: Viljakainen, Lumi
last_name: Viljakainen
- first_name: Jaana
full_name: Jurvansuu, Jaana
last_name: Jurvansuu
- first_name: Ida
full_name: Holmberg, Ida
last_name: Holmberg
- first_name: Tobias
full_name: Pamminger, Tobias
last_name: Pamminger
- first_name: Silvio
full_name: Erler, Silvio
last_name: Erler
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
citation:
ama: Viljakainen L, Jurvansuu J, Holmberg I, Pamminger T, Erler S, Cremer S. Social
environment affects the transcriptomic response to bacteria in ant queens. Ecology
and Evolution. 2018;8(22):11031-11070. doi:10.1002/ece3.4573
apa: Viljakainen, L., Jurvansuu, J., Holmberg, I., Pamminger, T., Erler, S., &
Cremer, S. (2018). Social environment affects the transcriptomic response to bacteria
in ant queens. Ecology and Evolution. Wiley. https://doi.org/10.1002/ece3.4573
chicago: Viljakainen, Lumi, Jaana Jurvansuu, Ida Holmberg, Tobias Pamminger, Silvio
Erler, and Sylvia Cremer. “Social Environment Affects the Transcriptomic Response
to Bacteria in Ant Queens.” Ecology and Evolution. Wiley, 2018. https://doi.org/10.1002/ece3.4573.
ieee: L. Viljakainen, J. Jurvansuu, I. Holmberg, T. Pamminger, S. Erler, and S.
Cremer, “Social environment affects the transcriptomic response to bacteria in
ant queens,” Ecology and Evolution, vol. 8, no. 22. Wiley, pp. 11031–11070,
2018.
ista: Viljakainen L, Jurvansuu J, Holmberg I, Pamminger T, Erler S, Cremer S. 2018.
Social environment affects the transcriptomic response to bacteria in ant queens.
Ecology and Evolution. 8(22), 11031–11070.
mla: Viljakainen, Lumi, et al. “Social Environment Affects the Transcriptomic Response
to Bacteria in Ant Queens.” Ecology and Evolution, vol. 8, no. 22, Wiley,
2018, pp. 11031–70, doi:10.1002/ece3.4573.
short: L. Viljakainen, J. Jurvansuu, I. Holmberg, T. Pamminger, S. Erler, S. Cremer,
Ecology and Evolution 8 (2018) 11031–11070.
date_created: 2018-12-11T11:44:15Z
date_published: 2018-11-01T00:00:00Z
date_updated: 2023-09-19T09:29:12Z
day: '01'
ddc:
- '576'
- '591'
department:
- _id: SyCr
doi: 10.1002/ece3.4573
external_id:
isi:
- '000451611000032'
file:
- access_level: open_access
checksum: 0d1355c78627ca7210aadd9a17a01915
content_type: application/pdf
creator: dernst
date_created: 2018-12-17T08:27:04Z
date_updated: 2020-07-14T12:45:52Z
file_id: '5682'
file_name: Viljakainen_et_al-2018-Ecology_and_Evolution.pdf
file_size: 1272096
relation: main_file
file_date_updated: 2020-07-14T12:45:52Z
has_accepted_license: '1'
intvolume: ' 8'
isi: 1
issue: '22'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 11031-11070
publication: Ecology and Evolution
publication_identifier:
issn:
- '20457758'
publication_status: published
publisher: Wiley
publist_id: '8026'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Social environment affects the transcriptomic response to bacteria in ant queens
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 8
year: '2018'
...
---
_id: '806'
abstract:
- lang: eng
text: Social insect colonies have evolved many collectively performed adaptations
that reduce the impact of infectious disease and that are expected to maximize
their fitness. This colony-level protection is termed social immunity, and it
enhances the health and survival of the colony. In this review, we address how
social immunity emerges from its mechanistic components to produce colony-level
disease avoidance, resistance, and tolerance. To understand the evolutionary causes
and consequences of social immunity, we highlight the need for studies that evaluate
the effects of social immunity on colony fitness. We discuss the role that host
life history and ecology have on predicted eco-evolutionary dynamics, which differ
among the social insect lineages. Throughout the review, we highlight current
gaps in our knowledge and promising avenues for future research, which we hope
will bring us closer to an integrated understanding of socio-eco-evo-immunology.
article_processing_charge: No
author:
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Christopher
full_name: Pull, Christopher
id: 3C7F4840-F248-11E8-B48F-1D18A9856A87
last_name: Pull
orcid: 0000-0003-1122-3982
- first_name: Matthias
full_name: Fürst, Matthias
id: 393B1196-F248-11E8-B48F-1D18A9856A87
last_name: Fürst
orcid: 0000-0002-3712-925X
citation:
ama: 'Cremer S, Pull C, Fürst M. Social immunity: Emergence and evolution of colony-level
disease protection. Annual Review of Entomology. 2018;63:105-123. doi:10.1146/annurev-ento-020117-043110'
apa: 'Cremer, S., Pull, C., & Fürst, M. (2018). Social immunity: Emergence and
evolution of colony-level disease protection. Annual Review of Entomology.
Annual Reviews. https://doi.org/10.1146/annurev-ento-020117-043110'
chicago: 'Cremer, Sylvia, Christopher Pull, and Matthias Fürst. “Social Immunity:
Emergence and Evolution of Colony-Level Disease Protection.” Annual Review
of Entomology. Annual Reviews, 2018. https://doi.org/10.1146/annurev-ento-020117-043110.'
ieee: 'S. Cremer, C. Pull, and M. Fürst, “Social immunity: Emergence and evolution
of colony-level disease protection,” Annual Review of Entomology, vol.
63. Annual Reviews, pp. 105–123, 2018.'
ista: 'Cremer S, Pull C, Fürst M. 2018. Social immunity: Emergence and evolution
of colony-level disease protection. Annual Review of Entomology. 63, 105–123.'
mla: 'Cremer, Sylvia, et al. “Social Immunity: Emergence and Evolution of Colony-Level
Disease Protection.” Annual Review of Entomology, vol. 63, Annual Reviews,
2018, pp. 105–23, doi:10.1146/annurev-ento-020117-043110.'
short: S. Cremer, C. Pull, M. Fürst, Annual Review of Entomology 63 (2018) 105–123.
date_created: 2018-12-11T11:48:36Z
date_published: 2018-01-07T00:00:00Z
date_updated: 2023-09-19T09:29:45Z
day: '07'
department:
- _id: SyCr
doi: 10.1146/annurev-ento-020117-043110
external_id:
isi:
- '000424633700008'
intvolume: ' 63'
isi: 1
language:
- iso: eng
month: '01'
oa_version: None
page: 105 - 123
publication: Annual Review of Entomology
publication_identifier:
issn:
- 1545-4487
publication_status: published
publisher: Annual Reviews
publist_id: '6844'
quality_controlled: '1'
related_material:
record:
- id: '819'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: 'Social immunity: Emergence and evolution of colony-level disease protection'
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 63
year: '2018'
...
---
_id: '7'
abstract:
- lang: eng
text: Animal social networks are shaped by multiple selection pressures, including
the need to ensure efficient communication and functioning while simultaneously
limiting disease transmission. Social animals could potentially further reduce
epidemic risk by altering their social networks in the presence of pathogens,
yet there is currently no evidence for such pathogen-triggered responses. We tested
this hypothesis experimentally in the ant Lasius niger using a combination of
automated tracking, controlled pathogen exposure, transmission quantification,
and temporally explicit simulations. Pathogen exposure induced behavioral changes
in both exposed ants and their nestmates, which helped contain the disease by
reinforcing key transmission-inhibitory properties of the colony's contact network.
This suggests that social network plasticity in response to pathogens is an effective
strategy for mitigating the effects of disease in social groups.
acknowledgement: This project was funded by two European Research Council Advanced
Grants (Social Life, 249375, and resiliANT, 741491) and two Swiss National Science
Foundation grants (CR32I3_141063 and 310030_156732) to L.K. and a European Research
Council Starting Grant (SocialVaccines, 243071) to S.C.
article_processing_charge: No
article_type: original
author:
- first_name: Nathalie
full_name: Stroeymeyt, Nathalie
last_name: Stroeymeyt
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Alessandro
full_name: Crespi, Alessandro
last_name: Crespi
- first_name: Danielle
full_name: Mersch, Danielle
last_name: Mersch
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Laurent
full_name: Keller, Laurent
last_name: Keller
citation:
ama: Stroeymeyt N, Grasse AV, Crespi A, Mersch D, Cremer S, Keller L. Social network
plasticity decreases disease transmission in a eusocial insect. Science.
2018;362(6417):941-945. doi:10.1126/science.aat4793
apa: Stroeymeyt, N., Grasse, A. V., Crespi, A., Mersch, D., Cremer, S., & Keller,
L. (2018). Social network plasticity decreases disease transmission in a eusocial
insect. Science. AAAS. https://doi.org/10.1126/science.aat4793
chicago: Stroeymeyt, Nathalie, Anna V Grasse, Alessandro Crespi, Danielle Mersch,
Sylvia Cremer, and Laurent Keller. “Social Network Plasticity Decreases Disease
Transmission in a Eusocial Insect.” Science. AAAS, 2018. https://doi.org/10.1126/science.aat4793.
ieee: N. Stroeymeyt, A. V. Grasse, A. Crespi, D. Mersch, S. Cremer, and L. Keller,
“Social network plasticity decreases disease transmission in a eusocial insect,”
Science, vol. 362, no. 6417. AAAS, pp. 941–945, 2018.
ista: Stroeymeyt N, Grasse AV, Crespi A, Mersch D, Cremer S, Keller L. 2018. Social
network plasticity decreases disease transmission in a eusocial insect. Science.
362(6417), 941–945.
mla: Stroeymeyt, Nathalie, et al. “Social Network Plasticity Decreases Disease Transmission
in a Eusocial Insect.” Science, vol. 362, no. 6417, AAAS, 2018, pp. 941–45,
doi:10.1126/science.aat4793.
short: N. Stroeymeyt, A.V. Grasse, A. Crespi, D. Mersch, S. Cremer, L. Keller, Science
362 (2018) 941–945.
date_created: 2018-12-11T11:44:07Z
date_published: 2018-11-23T00:00:00Z
date_updated: 2023-10-17T11:50:05Z
day: '23'
department:
- _id: SyCr
doi: 10.1126/science.aat4793
ec_funded: 1
external_id:
isi:
- '000451124500041'
intvolume: ' 362'
isi: 1
issue: '6417'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://serval.unil.ch/resource/serval:BIB_E9228C205467.P001/REF.pdf
month: '11'
oa: 1
oa_version: Published Version
page: 941 - 945
project:
- _id: 25DC711C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '243071'
name: 'Social Vaccination in Ant Colonies: from Individual Mechanisms to Society
Effects'
publication: Science
publication_identifier:
issn:
- 1095-9203
publication_status: published
publisher: AAAS
publist_id: '8049'
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/for-ants-unity-is-strength-and-health/
record:
- id: '13055'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Social network plasticity decreases disease transmission in a eusocial insect
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 362
year: '2018'
...
---
_id: '13055'
abstract:
- lang: eng
text: "Dataset for manuscript 'Social network plasticity decreases disease transmission
in a eusocial insect'\r\nCompared to previous versions: - raw image files added\r\n
\ - correction of URLs within
README.txt file\r\n"
article_processing_charge: No
author:
- first_name: Nathalie
full_name: Stroeymeyt, Nathalie
last_name: Stroeymeyt
- first_name: Anna V
full_name: Grasse, Anna V
id: 406F989C-F248-11E8-B48F-1D18A9856A87
last_name: Grasse
- first_name: Alessandro
full_name: Crespi, Alessandro
last_name: Crespi
- first_name: Danielle
full_name: Mersch, Danielle
last_name: Mersch
- first_name: Sylvia
full_name: Cremer, Sylvia
id: 2F64EC8C-F248-11E8-B48F-1D18A9856A87
last_name: Cremer
orcid: 0000-0002-2193-3868
- first_name: Laurent
full_name: Keller, Laurent
last_name: Keller
citation:
ama: Stroeymeyt N, Grasse AV, Crespi A, Mersch D, Cremer S, Keller L. Social network
plasticity decreases disease transmission in a eusocial insect. 2018. doi:10.5281/ZENODO.1322669
apa: Stroeymeyt, N., Grasse, A. V., Crespi, A., Mersch, D., Cremer, S., & Keller,
L. (2018). Social network plasticity decreases disease transmission in a eusocial
insect. Zenodo. https://doi.org/10.5281/ZENODO.1322669
chicago: Stroeymeyt, Nathalie, Anna V Grasse, Alessandro Crespi, Danielle Mersch,
Sylvia Cremer, and Laurent Keller. “Social Network Plasticity Decreases Disease
Transmission in a Eusocial Insect.” Zenodo, 2018. https://doi.org/10.5281/ZENODO.1322669.
ieee: N. Stroeymeyt, A. V. Grasse, A. Crespi, D. Mersch, S. Cremer, and L. Keller,
“Social network plasticity decreases disease transmission in a eusocial insect.”
Zenodo, 2018.
ista: Stroeymeyt N, Grasse AV, Crespi A, Mersch D, Cremer S, Keller L. 2018. Social
network plasticity decreases disease transmission in a eusocial insect, Zenodo,
10.5281/ZENODO.1322669.
mla: Stroeymeyt, Nathalie, et al. Social Network Plasticity Decreases Disease
Transmission in a Eusocial Insect. Zenodo, 2018, doi:10.5281/ZENODO.1322669.
short: N. Stroeymeyt, A.V. Grasse, A. Crespi, D. Mersch, S. Cremer, L. Keller, (2018).
date_created: 2023-05-23T13:24:51Z
date_published: 2018-10-23T00:00:00Z
date_updated: 2023-10-17T11:50:04Z
day: '23'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.5281/ZENODO.1322669
main_file_link:
- open_access: '1'
url: https://doi.org/10.5281/zenodo.1480665
month: '10'
oa: 1
oa_version: Published Version
publisher: Zenodo
related_material:
record:
- id: '7'
relation: used_in_publication
status: public
status: public
title: Social network plasticity decreases disease transmission in a eusocial insect
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2018'
...
---
_id: '1006'
abstract:
- lang: eng
text: 'Background: The phenomenon of immune priming, i.e. enhanced protection following
a secondary exposure to a pathogen, has now been demonstrated in a wide range
of invertebrate species. Despite accumulating phenotypic evidence, knowledge of
its mechanistic underpinnings is currently very limited. Here we used the system
of the red flour beetle, Tribolium castaneum and the insect pathogen Bacillus
thuringiensis (Bt) to further our molecular understanding of the oral immune priming
phenomenon. We addressed how ingestion of bacterial cues (derived from spore supernatants)
of an orally pathogenic and non-pathogenic Bt strain affects gene expression upon
later challenge exposure, using a whole-transcriptome sequencing approach. Results:
Whereas gene expression of individuals primed with the orally non-pathogenic strain
showed minor changes to controls, we found that priming with the pathogenic strain
induced regulation of a large set of distinct genes, many of which are known immune
candidates. Intriguingly, the immune repertoire activated upon priming and subsequent
challenge qualitatively differed from the one mounted upon infection with Bt without
previous priming. Moreover, a large subset of priming-specific genes showed an
inverse regulation compared to their regulation upon challenge only. Conclusions:
Our data demonstrate that gene expression upon infection is strongly affected
by previous immune priming. We hypothesise that this shift in gene expression
indicates activation of a more targeted and efficient response towards a previously
encountered pathogen, in anticipation of potential secondary encounter.'
article_processing_charge: No
author:
- first_name: Jenny
full_name: Greenwood, Jenny
last_name: Greenwood
- first_name: Barbara
full_name: Milutinovic, Barbara
id: 2CDC32B8-F248-11E8-B48F-1D18A9856A87
last_name: Milutinovic
orcid: 0000-0002-8214-4758
- first_name: Robert
full_name: Peuß, Robert
last_name: Peuß
- first_name: Sarah
full_name: Behrens, Sarah
last_name: Behrens
- first_name: Daniela
full_name: Essar, Daniela
last_name: Essar
- first_name: Philip
full_name: Rosenstiel, Philip
last_name: Rosenstiel
- first_name: Hinrich
full_name: Schulenburg, Hinrich
last_name: Schulenburg
- first_name: Joachim
full_name: Kurtz, Joachim
last_name: Kurtz
citation:
ama: Greenwood J, Milutinovic B, Peuß R, et al. Oral immune priming with Bacillus
thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae.
BMC Genomics. 2017;18(1):329. doi:10.1186/s12864-017-3705-7
apa: Greenwood, J., Milutinovic, B., Peuß, R., Behrens, S., Essar, D., Rosenstiel,
P., … Kurtz, J. (2017). Oral immune priming with Bacillus thuringiensis induces
a shift in the gene expression of Tribolium castaneum larvae. BMC Genomics.
BioMed Central. https://doi.org/10.1186/s12864-017-3705-7
chicago: Greenwood, Jenny, Barbara Milutinovic, Robert Peuß, Sarah Behrens, Daniela
Essar, Philip Rosenstiel, Hinrich Schulenburg, and Joachim Kurtz. “Oral Immune
Priming with Bacillus Thuringiensis Induces a Shift in the Gene Expression of
Tribolium Castaneum Larvae.” BMC Genomics. BioMed Central, 2017. https://doi.org/10.1186/s12864-017-3705-7.
ieee: J. Greenwood et al., “Oral immune priming with Bacillus thuringiensis
induces a shift in the gene expression of Tribolium castaneum larvae,” BMC
Genomics, vol. 18, no. 1. BioMed Central, p. 329, 2017.
ista: Greenwood J, Milutinovic B, Peuß R, Behrens S, Essar D, Rosenstiel P, Schulenburg
H, Kurtz J. 2017. Oral immune priming with Bacillus thuringiensis induces a shift
in the gene expression of Tribolium castaneum larvae. BMC Genomics. 18(1), 329.
mla: Greenwood, Jenny, et al. “Oral Immune Priming with Bacillus Thuringiensis Induces
a Shift in the Gene Expression of Tribolium Castaneum Larvae.” BMC Genomics,
vol. 18, no. 1, BioMed Central, 2017, p. 329, doi:10.1186/s12864-017-3705-7.
short: J. Greenwood, B. Milutinovic, R. Peuß, S. Behrens, D. Essar, P. Rosenstiel,
H. Schulenburg, J. Kurtz, BMC Genomics 18 (2017) 329.
date_created: 2018-12-11T11:49:39Z
date_published: 2017-04-26T00:00:00Z
date_updated: 2023-09-22T09:47:44Z
day: '26'
ddc:
- '570'
department:
- _id: SyCr
doi: 10.1186/s12864-017-3705-7
external_id:
isi:
- '000400625200004'
file:
- access_level: open_access
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:16:46Z
date_updated: 2018-12-12T10:16:46Z
file_id: '5236'
file_name: IST-2017-814-v1+1_s12864-017-3705-7.pdf
file_size: 2379672
relation: main_file
file_date_updated: 2018-12-12T10:16:46Z
has_accepted_license: '1'
intvolume: ' 18'
isi: 1
issue: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: '329'
publication: BMC Genomics
publication_identifier:
issn:
- '14712164'
publication_status: published
publisher: BioMed Central
publist_id: '6392'
pubrep_id: '814'
quality_controlled: '1'
related_material:
record:
- id: '9859'
relation: research_data
status: public
- id: '9860'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Oral immune priming with Bacillus thuringiensis induces a shift in the gene
expression of Tribolium castaneum larvae
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 18
year: '2017'
...
---
_id: '9859'
abstract:
- lang: eng
text: 'Lists of all differentially expressed genes in the different priming-challenge
treatments (compared to the fully naïve control; xlsx file). Relevant columns
include the following: sample_1 and sample_2 – treatment groups being compared;
Normalised FPKM sample_1 and sample_2 – FPKM of samples being compared; log2(fold_change)
– log2(FPKM sample 2/FPKM sample 1), i.e. negative means sample 1 upregulated
compared with sample 2, positive means sample 2 upregulated compared with sample
1; cuffdiff test_statistic – test statistic of differential expression test; p_value
– p-value of differential expression test; q_value (FDR correction) – adjusted
P-value of differential expression test. (XLSX 598 kb)'
article_processing_charge: No
author:
- first_name: Jenny
full_name: Greenwood, Jenny
last_name: Greenwood
- first_name: Barbara
full_name: Milutinovic, Barbara
id: 2CDC32B8-F248-11E8-B48F-1D18A9856A87
last_name: Milutinovic
orcid: 0000-0002-8214-4758
- first_name: Robert
full_name: Peuß, Robert
last_name: Peuß
- first_name: Sarah
full_name: Behrens, Sarah
last_name: Behrens
- first_name: Daniela
full_name: Essar, Daniela
last_name: Essar
- first_name: Philip
full_name: Rosenstiel, Philip
last_name: Rosenstiel
- first_name: Hinrich
full_name: Schulenburg, Hinrich
last_name: Schulenburg
- first_name: Joachim
full_name: Kurtz, Joachim
last_name: Kurtz
citation:
ama: 'Greenwood J, Milutinovic B, Peuß R, et al. Additional file 1: Table S1. of
Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression
of Tribolium castaneum larvae. 2017. doi:10.6084/m9.figshare.c.3756974_d1.v1'
apa: 'Greenwood, J., Milutinovic, B., Peuß, R., Behrens, S., Essar, D., Rosenstiel,
P., … Kurtz, J. (2017). Additional file 1: Table S1. of Oral immune priming with
Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum
larvae. Springer Nature. https://doi.org/10.6084/m9.figshare.c.3756974_d1.v1'
chicago: 'Greenwood, Jenny, Barbara Milutinovic, Robert Peuß, Sarah Behrens, Daniela
Essar, Philip Rosenstiel, Hinrich Schulenburg, and Joachim Kurtz. “Additional
File 1: Table S1. of Oral Immune Priming with Bacillus Thuringiensis Induces a
Shift in the Gene Expression of Tribolium Castaneum Larvae.” Springer Nature,
2017. https://doi.org/10.6084/m9.figshare.c.3756974_d1.v1.'
ieee: 'J. Greenwood et al., “Additional file 1: Table S1. of Oral immune
priming with Bacillus thuringiensis induces a shift in the gene expression of
Tribolium castaneum larvae.” Springer Nature, 2017.'
ista: 'Greenwood J, Milutinovic B, Peuß R, Behrens S, Essar D, Rosenstiel P, Schulenburg
H, Kurtz J. 2017. Additional file 1: Table S1. of Oral immune priming with Bacillus
thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae,
Springer Nature, 10.6084/m9.figshare.c.3756974_d1.v1.'
mla: 'Greenwood, Jenny, et al. Additional File 1: Table S1. of Oral Immune Priming
with Bacillus Thuringiensis Induces a Shift in the Gene Expression of Tribolium
Castaneum Larvae. Springer Nature, 2017, doi:10.6084/m9.figshare.c.3756974_d1.v1.'
short: J. Greenwood, B. Milutinovic, R. Peuß, S. Behrens, D. Essar, P. Rosenstiel,
H. Schulenburg, J. Kurtz, (2017).
date_created: 2021-08-10T07:59:02Z
date_published: 2017-04-26T00:00:00Z
date_updated: 2023-09-22T09:47:44Z
day: '26'
department:
- _id: SyCr
doi: 10.6084/m9.figshare.c.3756974_d1.v1
main_file_link:
- open_access: '1'
url: https://doi.org/10.6084/m9.figshare.c.3756974_d1.v1
month: '04'
oa: 1
oa_version: Published Version
publisher: Springer Nature
related_material:
record:
- id: '1006'
relation: used_in_publication
status: public
status: public
title: 'Additional file 1: Table S1. of Oral immune priming with Bacillus thuringiensis
induces a shift in the gene expression of Tribolium castaneum larvae'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2017'
...