[{"citation":{"chicago":"Franschitz, Anna. “Individual and Social Immunity against Viral Infections in Ants.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:13984.","ista":"Franschitz A. 2023. Individual and social immunity against viral infections in ants. Institute of Science and Technology Austria.","mla":"Franschitz, Anna. Individual and Social Immunity against Viral Infections in Ants. Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:13984.","ieee":"A. Franschitz, “Individual and social immunity against viral infections in ants,” Institute of Science and Technology Austria, 2023.","short":"A. Franschitz, Individual and Social Immunity against Viral Infections in Ants, Institute of Science and Technology Austria, 2023.","ama":"Franschitz A. Individual and social immunity against viral infections in ants. 2023. doi:10.15479/at:ista:13984","apa":"Franschitz, A. (2023). Individual and social immunity against viral infections in ants. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:13984"},"user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","author":[{"last_name":"Franschitz","full_name":"Franschitz, Anna","id":"480826C8-F248-11E8-B48F-1D18A9856A87","first_name":"Anna"}],"article_processing_charge":"No","title":"Individual and social immunity against viral infections in ants","has_accepted_license":"1","year":"2023","day":"08","page":"89","date_published":"2023-08-08T00:00:00Z","doi":"10.15479/at:ista:13984","date_created":"2023-08-08T15:33:29Z","publisher":"Institute of Science and Technology Austria","supervisor":[{"orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia","last_name":"Cremer","first_name":"Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"}],"date_updated":"2024-03-01T15:25:17Z","ddc":["570","577"],"department":[{"_id":"GradSch"},{"_id":"SyCr"}],"file_date_updated":"2024-03-01T12:58:14Z","_id":"13984","type":"dissertation","status":"public","publication_identifier":{"issn":["2663 - 337X"],"isbn":["978-3-99078-034-3"]},"degree_awarded":"PhD","publication_status":"published","file":[{"access_level":"closed","relation":"main_file","content_type":"application/pdf","embargo_to":"open_access","file_id":"13986","checksum":"27220243d5d51c3b0d7d61c0879d7a0c","embargo":"2024-08-08","creator":"afransch","date_updated":"2024-03-01T08:51:42Z","file_size":10797612,"date_created":"2023-08-08T18:01:28Z","file_name":"Thesis_AnnaFranschitz_202308.pdf"},{"file_id":"13987","checksum":"40abf7ccca14a3893f72dc7fb88585d6","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","access_level":"closed","relation":"source_file","date_created":"2023-08-08T18:02:25Z","file_name":"Thesis_AnnaFranschitz_202308.docx","date_updated":"2023-08-09T07:25:27Z","file_size":2619085,"creator":"afransch"},{"file_name":"Addendum_AnnaFranschitz202402.pdf","date_created":"2024-03-01T08:37:15Z","title":"Addendum","creator":"cchlebak","file_size":85956,"date_updated":"2024-03-01T12:13:29Z","embargo":"2024-08-08","file_id":"15042","checksum":"8b991ecc2d59d045cc3cf0d676785ec7","relation":"erratum","access_level":"closed","embargo_to":"open_access","content_type":"application/pdf","description":"Minor modifications and clarifications - Feb 2024"},{"content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","access_level":"closed","relation":"source_file","checksum":"66745aa01f960f17472c024875c049ed","file_id":"15043","date_updated":"2024-03-01T08:51:42Z","file_size":11818,"creator":"cchlebak","date_created":"2024-03-01T08:39:20Z","title":"Addendum - source file","file_name":"Addendum_AnnaFranschitz202402.docx"},{"creator":"cchlebak","date_updated":"2024-03-01T12:58:14Z","file_size":10416761,"title":"Print Version","date_created":"2024-03-01T08:56:06Z","file_name":"Print_Version_Franschitz_Anna_Thesis.pdf","access_level":"closed","relation":"other","description":"For printing purposes","content_type":"application/pdf","checksum":"55c876b73d49db15228a7f571592ec77","file_id":"15044"}],"language":[{"iso":"eng"}],"abstract":[{"text":"Social insects fight disease using their individual immune systems and the cooperative\r\nsanitary behaviors of colony members. These social defenses are well explored against\r\nexternally-infecting pathogens, but little is known about defense strategies against\r\ninternally-infecting pathogens, such as viruses. Viruses are ubiquitous and in the last decades\r\nit has become evident that also many ant species harbor viruses. We present one of the first\r\nstudies addressing transmission dynamics and collective disease defenses against viruses in\r\nants on a mechanistic level. I successfully established an experimental ant host – viral\r\npathogen system as a model for the defense strategies used by social insects against internal\r\npathogen infections, as outlined in the third chapter. In particular, we studied how garden ants\r\n(Lasius neglectus) defend themselves and their colonies against the generalist insect virus\r\nCrPV (cricket paralysis virus). We chose microinjections of virus directly into the ants’\r\nhemolymph because it allowed us to use a defined exposure dose. Here we show that this is a\r\ngood model system, as the virus is replicating and thus infecting the host. The ants mount a\r\nclear individual immune response against the viral infection, which is characterized by a\r\nspecific siRNA pattern, namely siRNAs mapping against the viral genome with a peak of 21\r\nand 22 bp long fragments. The onset of this immune response is consistent with the timeline\r\nof viral replication that starts already within two days post injection. The disease manifests in\r\ndecreased survival over a course of two to three weeks.\r\nRegarding group living, we find that infected ants show a strong individual immune response,\r\nbut that their course of disease is little affected by nestmate presence, as described in chapter\r\nfour. Hence, we do not find social immunity in the context of viral infections in ants.\r\nNestmates, however, can contract the virus. Using Drosophila S2R+ cells in culture, we\r\nshowed that 94 % of the nestmates contract active virus within four days of social contact to\r\nan infected individual. Virus is transmitted in low doses, thus not causing disease\r\ntransmission within the colony. While virus can be transmitted during short direct contacts,\r\nwe also assume transmission from deceased ants and show that the nestmates’ immune\r\nsystem gets activated after contracting a low viral dose. We find considerable potential for\r\nindirect transmission via the nest space. Virus is shed to the nest, where it stays viable for one\r\nweek and is also picked up by other ants. Apart from that, we want to underline the potential\r\nof ant poison as antiviral agent. We determined that ant poison successfully inactivates CrPV\r\nin vitro. However, we found no evidence for effective poison use to sanitize the nest space.\r\nOn the other hand, local application of ant poison by oral poison uptake, which is part of the\r\nants prophylactic behavioral repertoire, probably contributes to keeping the gut of each\r\nindividual sanitized. We hypothesize that oral poison uptake might be the reason why we did\r\nnot find viable virus in the trophallactic fluid.\r\nThe fifth chapter encompasses preliminary data on potential social immunization. However,\r\nour experiments do not confirm an actual survival benefit for the nestmates upon pathogen\r\nchallenge under the given experimental settings. Nevertheless, we do not want to rule out the\r\npossibility for nestmate immunization, but rather emphasize that considering different\r\nexperimental timelines and viral doses would provide a multitude of options for follow-up\r\nexperiments.\r\nIn conclusion, we find that prophylactic individual behaviors, such as oral poison uptake,\r\nmight play a role in preventing viral disease transmission. Compared to colony defense\r\nagainst external pathogens, internal pathogen infections require a stronger component of\r\nindividual physiological immunity than behavioral social immunity, yet could still lead to\r\ncollective protection.","lang":"eng"}],"acknowledged_ssus":[{"_id":"LifeSc"}],"oa_version":"Published Version","alternative_title":["ISTA Thesis"],"month":"08"},{"volume":22,"issue":"12","publication_status":"published","publication_identifier":{"eissn":["1474-1741"],"issn":["1474-1733"]},"language":[{"iso":"eng"}],"scopus_import":"1","intvolume":" 22","month":"12","abstract":[{"text":"Social distancing is an effective way to prevent the spread of disease in societies, whereas infection elimination is a key element of organismal immunity. Here, we discuss how the study of social insects such as ants — which form a superorganism of unconditionally cooperative individuals and thus represent a level of organization that is intermediate between a classical society of individuals and an organism of cells — can help to determine common principles of disease defence across levels of organization.","lang":"eng"}],"pmid":1,"oa_version":"None","department":[{"_id":"SyCr"},{"_id":"MiSi"}],"date_updated":"2023-08-04T08:53:32Z","article_type":"letter_note","type":"journal_article","keyword":["Energy Engineering and Power Technology","Fuel Technology"],"status":"public","_id":"12133","page":"713-714","date_created":"2023-01-12T12:03:14Z","date_published":"2022-12-01T00:00:00Z","doi":"10.1038/s41577-022-00797-y","year":"2022","isi":1,"publication":"Nature Reviews Immunology","day":"01","publisher":"Springer Nature","quality_controlled":"1","article_processing_charge":"No","external_id":{"isi":["000871836300001"],"pmid":["36284178"]},"author":[{"first_name":"Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","last_name":"Cremer","full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868"},{"full_name":"Sixt, Michael K","orcid":"0000-0002-6620-9179","last_name":"Sixt","first_name":"Michael K","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87"}],"title":"Principles of disease defence in organisms, superorganisms and societies","citation":{"apa":"Cremer, S., & Sixt, M. K. (2022). Principles of disease defence in organisms, superorganisms and societies. Nature Reviews Immunology. Springer Nature. https://doi.org/10.1038/s41577-022-00797-y","ama":"Cremer S, Sixt MK. Principles of disease defence in organisms, superorganisms and societies. Nature Reviews Immunology. 2022;22(12):713-714. doi:10.1038/s41577-022-00797-y","ieee":"S. Cremer and M. K. Sixt, “Principles of disease defence in organisms, superorganisms and societies,” Nature Reviews Immunology, vol. 22, no. 12. Springer Nature, pp. 713–714, 2022.","short":"S. Cremer, M.K. Sixt, Nature Reviews Immunology 22 (2022) 713–714.","mla":"Cremer, Sylvia, and Michael K. Sixt. “Principles of Disease Defence in Organisms, Superorganisms and Societies.” Nature Reviews Immunology, vol. 22, no. 12, Springer Nature, 2022, pp. 713–14, doi:10.1038/s41577-022-00797-y.","ista":"Cremer S, Sixt MK. 2022. Principles of disease defence in organisms, superorganisms and societies. Nature Reviews Immunology. 22(12), 713–714.","chicago":"Cremer, Sylvia, and Michael K Sixt. “Principles of Disease Defence in Organisms, Superorganisms and Societies.” Nature Reviews Immunology. Springer Nature, 2022. https://doi.org/10.1038/s41577-022-00797-y."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8"},{"date_updated":"2023-08-14T11:45:29Z","ddc":["573"],"department":[{"_id":"SyCr"}],"file_date_updated":"2022-02-03T13:37:11Z","_id":"10284","article_type":"original","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"status":"public","publication_identifier":{"eissn":["1461-0248"],"issn":["1461-023X"]},"publication_status":"published","file":[{"date_created":"2022-02-03T13:37:11Z","file_name":"2021_EcologyLetters_CasillasPerez.pdf","creator":"cchlebak","date_updated":"2022-02-03T13:37:11Z","file_size":700087,"checksum":"0bd4210400e9876609b7c538ab4f9a3c","file_id":"10721","success":1,"access_level":"open_access","relation":"main_file","content_type":"application/pdf"}],"language":[{"iso":"eng"}],"related_material":{"record":[{"relation":"research_data","status":"public","id":"13061"}]},"issue":"1","volume":25,"ec_funded":1,"license":"https://creativecommons.org/licenses/by/4.0/","acknowledged_ssus":[{"_id":"ScienComp"}],"abstract":[{"text":"Infections early in life can have enduring effects on an organism's development and immunity. In this study, we show that this equally applies to developing ‘superorganisms’––incipient social insect colonies. When we exposed newly mated Lasius niger ant queens to a low pathogen dose, their colonies grew more slowly than controls before winter, but reached similar sizes afterwards. Independent of exposure, queen hibernation survival improved when the ratio of pupae to workers was small. Queens that reared fewer pupae before worker emergence exhibited lower pathogen levels, indicating that high brood rearing efforts interfere with the ability of the queen's immune system to suppress pathogen proliferation. Early-life queen pathogen exposure also improved the immunocompetence of her worker offspring, as demonstrated by challenging the workers to the same pathogen a year later. Transgenerational transfer of the queen's pathogen experience to her workforce can hence durably reduce the disease susceptibility of the whole superorganism.","lang":"eng"}],"oa_version":"Published Version","pmid":1,"scopus_import":"1","month":"01","intvolume":" 25","citation":{"ista":"Casillas Perez BE, Pull C, Naiser F, Naderlinger E, Matas J, Cremer S. 2022. Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies. Ecology Letters. 25(1), 89–100.","chicago":"Casillas Perez, Barbara E, Christopher Pull, Filip Naiser, Elisabeth Naderlinger, Jiri Matas, and Sylvia Cremer. “Early Queen Infection Shapes Developmental Dynamics and Induces Long-Term Disease Protection in Incipient Ant Colonies.” Ecology Letters. Wiley, 2022. https://doi.org/10.1111/ele.13907.","ama":"Casillas Perez BE, Pull C, Naiser F, Naderlinger E, Matas J, Cremer S. Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies. Ecology Letters. 2022;25(1):89-100. doi:10.1111/ele.13907","apa":"Casillas Perez, B. E., Pull, C., Naiser, F., Naderlinger, E., Matas, J., & Cremer, S. (2022). Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies. Ecology Letters. Wiley. https://doi.org/10.1111/ele.13907","ieee":"B. E. Casillas Perez, C. Pull, F. Naiser, E. Naderlinger, J. Matas, and S. Cremer, “Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies,” Ecology Letters, vol. 25, no. 1. Wiley, pp. 89–100, 2022.","short":"B.E. Casillas Perez, C. Pull, F. Naiser, E. Naderlinger, J. Matas, S. Cremer, Ecology Letters 25 (2022) 89–100.","mla":"Casillas Perez, Barbara E., et al. “Early Queen Infection Shapes Developmental Dynamics and Induces Long-Term Disease Protection in Incipient Ant Colonies.” Ecology Letters, vol. 25, no. 1, Wiley, 2022, pp. 89–100, doi:10.1111/ele.13907."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","author":[{"last_name":"Casillas Perez","full_name":"Casillas Perez, Barbara E","id":"351ED2AA-F248-11E8-B48F-1D18A9856A87","first_name":"Barbara E"},{"id":"3C7F4840-F248-11E8-B48F-1D18A9856A87","first_name":"Christopher","last_name":"Pull","full_name":"Pull, Christopher","orcid":"0000-0003-1122-3982"},{"last_name":"Naiser","full_name":"Naiser, Filip","first_name":"Filip"},{"id":"31757262-F248-11E8-B48F-1D18A9856A87","first_name":"Elisabeth","last_name":"Naderlinger","full_name":"Naderlinger, Elisabeth"},{"last_name":"Matas","full_name":"Matas, Jiri","first_name":"Jiri"},{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia","last_name":"Cremer","full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868"}],"article_processing_charge":"Yes (via OA deal)","external_id":{"pmid":["34725912"],"isi":["000713396100001"]},"title":"Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies","project":[{"grant_number":"771402","name":"Epidemics in ant societies on a chip","_id":"2649B4DE-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}],"isi":1,"has_accepted_license":"1","year":"2022","day":"01","publication":"Ecology Letters","page":"89-100","doi":"10.1111/ele.13907","date_published":"2022-01-01T00:00:00Z","date_created":"2021-11-14T23:01:25Z","acknowledgement":"The authors are grateful to G. Tkačik and V. Mireles for advice on data analyses and to A. Schloegl for help using the IST Austria HPC cluster for data processing. The authors thank J. Eilenberg for providing the fungal strain and A.V. Grasse for support with the molecular analysis. The authors also thank the Social Immunity group at IST Austria, in particular B. Milutinović, for discussions throughout and comments on the manuscript.","quality_controlled":"1","publisher":"Wiley","oa":1},{"file":[{"file_name":"Thesis_Sina_Metzler.docx","date_created":"2022-02-04T15:36:12Z","file_size":6757886,"date_updated":"2023-02-03T23:30:03Z","creator":"smetzler","checksum":"47ba18bb270dd6cc266e0a3f7c69d0e4","file_id":"10728","embargo_to":"open_access","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","relation":"source_file","access_level":"closed"},{"date_created":"2022-02-04T15:36:43Z","file_name":"Thesis_Sina_Metzler_A2.pdf","date_updated":"2023-02-03T23:30:03Z","file_size":6314921,"creator":"smetzler","checksum":"f3ec07d5d6b20ae6e46bfeedebce9027","file_id":"10730","embargo":"2023-02-02","content_type":"application/pdf","access_level":"open_access","relation":"main_file"},{"embargo":"2023-02-02","checksum":"dedd14b7be7a75d63018dbfc68dd8113","file_id":"10742","content_type":"application/pdf","relation":"main_file","access_level":"open_access","file_name":"Thesis_Sina_Metzler_print.pdf","date_created":"2022-02-07T10:35:02Z","file_size":6882557,"date_updated":"2023-02-04T23:30:03Z","creator":"smetzler"}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["2663-337X"]},"degree_awarded":"PhD","publication_status":"published","ec_funded":1,"oa_version":"Published Version","abstract":[{"text":"Social insects are a common model to study disease dynamics in social animals. Even though pathogens should thrive in social insect colonies as the hosts engage in frequent social interactions, are closely related and live in a pathogen-rich environment, disease outbreaks are rare. This is because social insects have evolved mechanisms to keep pathogens at bay – and fight disease as a collective. Social insect colonies are often viewed as “superorganisms” with division of labor between reproductive “germ-like” queens and males and “somatic” workers, which together form an interdependent reproductive unit that parallels a multicellular body. Superorganisms possess a “social immune system” that comprises of collective disease defenses performed by the workers - summarized as “social immunity”. In social groups immunization (reduced susceptibility to a parasite upon secondary exposure to the same parasite) can e.g. be triggered by social interactions (“social immunization”). Social immunization can be caused by (i) asymptomatic low-level infections that are acquired during caregiving to a contagious individual that can give an immune boost, which can induce protection upon later encounter with the same pathogen (active immunization) or (ii) by transfer of immune effectors between individuals (passive immunization).\r\nIn the second chapter, I built up on a study that I co-authored that found that low-level infections can not only be protective, but also be costly and make the host more susceptible to detrimental superinfections after contact to a very dissimilar pathogen. I here now tested different degrees of phylogenetically-distant fungal strains of M. brunneum and M. robertsii in L. neglectus and can describe the occurrence of cross-protection of social immunization if the first and second pathogen are from the same level. Interestingly, low-level infections only provided protection when the first strain was less virulent than the second strain and elicited higher immune gene expression.\r\nIn the third and fourth chapters, I expanded on the role of social immunity in sexual selection, a so far unstudied field. I used the fungus Metarhizium robertsii and the ant Cardiocondyla obscurior as a model, as in this species mating occurs in the presence of workers and can be studied under laboratory conditions. Before males mate with virgin queens in the nest they engage in fierce combat over the access to their mating partners.\r\nFirst, I focused on male-male competition in the third chapter and found that fighting with a contagious male is costly as it can lead to contamination of the rival, but that workers can decrease the risk of disease contraction by performing sanitary care.\r\nIn the fourth chapter, I studied the effect of fungal infection on survival and mating success of sexuals (freshly emerged queens and males) and found that worker-performed sanitary care can buffer the negative effect that a pathogenic contagion would have on sexuals by spore removal from the exposed individuals. When social immunity was prevented and queens could contract spores from their mating partner, very low dosages led to negative consequences: their lifespan was reduced and they produced fewer offspring with poor immunocompetence compared to healthy queens. Interestingly, cohabitation with a late-stage infected male where no spore transfer was possible had a positive effect on offspring immunity – male offspring of mothers that apparently perceived an infected partner in their vicinity reacted more sensitively to fungal challenge than male offspring without paternal pathogen history.","lang":"eng"}],"acknowledged_ssus":[{"_id":"LifeSc"}],"month":"02","alternative_title":["ISTA Thesis"],"ddc":["570"],"supervisor":[{"last_name":"Cremer","orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia","first_name":"Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"}],"date_updated":"2023-09-07T13:43:23Z","department":[{"_id":"GradSch"},{"_id":"SyCr"}],"file_date_updated":"2023-02-04T23:30:03Z","_id":"10727","status":"public","type":"dissertation","day":"07","has_accepted_license":"1","year":"2022","doi":"10.15479/AT:ISTA:10727","date_published":"2022-02-07T00:00:00Z","date_created":"2022-02-04T15:45:12Z","publisher":"Institute of Science and Technology Austria","oa":1,"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"ista":"Metzler S. 2022. Pathogen-mediated sexual selection and immunization in ant colonies. Institute of Science and Technology Austria.","chicago":"Metzler, Sina. “Pathogen-Mediated Sexual Selection and Immunization in Ant Colonies.” Institute of Science and Technology Austria, 2022. https://doi.org/10.15479/AT:ISTA:10727.","apa":"Metzler, S. (2022). Pathogen-mediated sexual selection and immunization in ant colonies. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:10727","ama":"Metzler S. Pathogen-mediated sexual selection and immunization in ant colonies. 2022. doi:10.15479/AT:ISTA:10727","short":"S. Metzler, Pathogen-Mediated Sexual Selection and Immunization in Ant Colonies, Institute of Science and Technology Austria, 2022.","ieee":"S. Metzler, “Pathogen-mediated sexual selection and immunization in ant colonies,” Institute of Science and Technology Austria, 2022.","mla":"Metzler, Sina. Pathogen-Mediated Sexual Selection and Immunization in Ant Colonies. Institute of Science and Technology Austria, 2022, doi:10.15479/AT:ISTA:10727."},"title":"Pathogen-mediated sexual selection and immunization in ant colonies","author":[{"last_name":"Metzler","full_name":"Metzler, Sina","orcid":"0000-0002-9547-2494","first_name":"Sina","id":"48204546-F248-11E8-B48F-1D18A9856A87"}],"article_processing_charge":"No","project":[{"call_identifier":"H2020","_id":"2649B4DE-B435-11E9-9278-68D0E5697425","name":"Epidemics in ant societies on a chip","grant_number":"771402"}]},{"author":[{"last_name":"Reber","full_name":"Reber, Stephan A.","first_name":"Stephan A."},{"id":"403169A4-080F-11EA-9993-BF3F3DDC885E","first_name":"Jinook","orcid":"0000-0001-7425-2372","full_name":"Oh, Jinook","last_name":"Oh"},{"last_name":"Janisch","full_name":"Janisch, Judith","first_name":"Judith"},{"full_name":"Stevenson, Colin","last_name":"Stevenson","first_name":"Colin"},{"last_name":"Foggett","full_name":"Foggett, Shaun","first_name":"Shaun"},{"last_name":"Wilkinson","full_name":"Wilkinson, Anna","first_name":"Anna"}],"article_processing_charge":"No","external_id":{"isi":["000608382100001"]},"title":"Early life differences in behavioral predispositions in two Alligatoridae species","citation":{"ista":"Reber SA, Oh J, Janisch J, Stevenson C, Foggett S, Wilkinson A. 2021. Early life differences in behavioral predispositions in two Alligatoridae species. Animal Cognition. 24(4), 753–764.","chicago":"Reber, Stephan A., Jinook Oh, Judith Janisch, Colin Stevenson, Shaun Foggett, and Anna Wilkinson. “Early Life Differences in Behavioral Predispositions in Two Alligatoridae Species.” Animal Cognition. Springer Nature, 2021. https://doi.org/10.1007/s10071-020-01461-5.","ama":"Reber SA, Oh J, Janisch J, Stevenson C, Foggett S, Wilkinson A. Early life differences in behavioral predispositions in two Alligatoridae species. Animal Cognition. 2021;24(4):753-764. doi:10.1007/s10071-020-01461-5","apa":"Reber, S. A., Oh, J., Janisch, J., Stevenson, C., Foggett, S., & Wilkinson, A. (2021). Early life differences in behavioral predispositions in two Alligatoridae species. Animal Cognition. Springer Nature. https://doi.org/10.1007/s10071-020-01461-5","ieee":"S. A. Reber, J. Oh, J. Janisch, C. Stevenson, S. Foggett, and A. Wilkinson, “Early life differences in behavioral predispositions in two Alligatoridae species,” Animal Cognition, vol. 24, no. 4. Springer Nature, pp. 753–764, 2021.","short":"S.A. Reber, J. Oh, J. Janisch, C. Stevenson, S. Foggett, A. Wilkinson, Animal Cognition 24 (2021) 753–764.","mla":"Reber, Stephan A., et al. “Early Life Differences in Behavioral Predispositions in Two Alligatoridae Species.” Animal Cognition, vol. 24, no. 4, Springer Nature, 2021, pp. 753–64, doi:10.1007/s10071-020-01461-5."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publisher":"Springer Nature","quality_controlled":"1","oa":1,"acknowledgement":"We thank Jamie Gilks and Terry Miles for their support at Crocodiles of the World. We are grateful to the Department of Cognitive Biology, University of Vienna for provision of working space and hardware. Finally, we would like to thank Cliodhna Quigley, Rachael Harrison and Urs A. Reber for discussion. Open Access funding provided by Lund University. This project was funded by the Marietta Blau grant (BMFWF) to S. A. R.","page":"753-764","doi":"10.1007/s10071-020-01461-5","date_published":"2021-07-01T00:00:00Z","date_created":"2021-02-07T23:01:13Z","has_accepted_license":"1","isi":1,"year":"2021","day":"01","publication":"Animal Cognition","article_type":"original","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"status":"public","_id":"9101","file_date_updated":"2021-02-09T07:40:14Z","department":[{"_id":"SyCr"}],"date_updated":"2023-08-07T13:41:08Z","ddc":["590"],"scopus_import":"1","month":"07","intvolume":" 24","abstract":[{"lang":"eng","text":"Behavioral predispositions are innate tendencies of animals to behave in a given way without the input of learning. They increase survival chances and, due to environmental and ecological challenges, may vary substantially even between closely related taxa. These differences are likely to be especially pronounced in long-lived species like crocodilians. This order is particularly relevant for comparative cognition due to its phylogenetic proximity to birds. Here we compared early life behavioral predispositions in two Alligatoridae species. We exposed American alligator and spectacled caiman hatchlings to three different novel situations: a novel object, a novel environment that was open and a novel environment with a shelter. This was then repeated a week later. During exposure to the novel environments, alligators moved around more and explored a larger range of the arena than the caimans. When exposed to the novel object, the alligators reduced the mean distance to the novel object in the second phase, while the caimans further increased it, indicating diametrically opposite ontogenetic development in behavioral predispositions. Although all crocodilian hatchlings face comparable challenges, e.g., high predation pressure, the effectiveness of parental protection might explain the observed pattern. American alligators are apex predators capable of protecting their offspring against most dangers, whereas adult spectacled caimans are frequently predated themselves. Their distancing behavior might be related to increased predator avoidance and also explain the success of invasive spectacled caimans in the natural habitats of other crocodilians."}],"oa_version":"Published Version","volume":24,"issue":"4","publication_identifier":{"eissn":["14359456"],"issn":["14359448"]},"publication_status":"published","file":[{"checksum":"d9dfa0d1de6d684692b041d936dd858e","file_id":"9107","success":1,"access_level":"open_access","relation":"main_file","content_type":"application/pdf","date_created":"2021-02-09T07:40:14Z","file_name":"2021_AnimalCognition_Reber.pdf","creator":"dernst","date_updated":"2021-02-09T07:40:14Z","file_size":1117991}],"language":[{"iso":"eng"}]},{"_id":"13061","tmp":{"image":"/images/cc_0.png","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","name":"Creative Commons Public Domain Dedication (CC0 1.0)","short":"CC0 (1.0)"},"type":"research_data_reference","status":"public","project":[{"_id":"2649B4DE-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","grant_number":"771402","name":"Epidemics in ant societies on a chip"}],"citation":{"short":"B.E. Casillas Perez, C. Pull, F. Naiser, E. Naderlinger, J. Matas, S. Cremer, (2021).","ieee":"B. E. Casillas Perez, C. Pull, F. Naiser, E. Naderlinger, J. Matas, and S. Cremer, “Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies.” Dryad, 2021.","apa":"Casillas Perez, B. E., Pull, C., Naiser, F., Naderlinger, E., Matas, J., & Cremer, S. (2021). Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies. Dryad. https://doi.org/10.5061/DRYAD.7PVMCVDTJ","ama":"Casillas Perez BE, Pull C, Naiser F, Naderlinger E, Matas J, Cremer S. Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies. 2021. doi:10.5061/DRYAD.7PVMCVDTJ","mla":"Casillas Perez, Barbara E., et al. Early Queen Infection Shapes Developmental Dynamics and Induces Long-Term Disease Protection in Incipient Ant Colonies. Dryad, 2021, doi:10.5061/DRYAD.7PVMCVDTJ.","ista":"Casillas Perez BE, Pull C, Naiser F, Naderlinger E, Matas J, Cremer S. 2021. Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies, Dryad, 10.5061/DRYAD.7PVMCVDTJ.","chicago":"Casillas Perez, Barbara E, Christopher Pull, Filip Naiser, Elisabeth Naderlinger, Jiri Matas, and Sylvia Cremer. “Early Queen Infection Shapes Developmental Dynamics and Induces Long-Term Disease Protection in Incipient Ant Colonies.” Dryad, 2021. https://doi.org/10.5061/DRYAD.7PVMCVDTJ."},"date_updated":"2023-08-14T11:45:28Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["570"],"article_processing_charge":"No","author":[{"last_name":"Casillas Perez","full_name":"Casillas Perez, Barbara E","id":"351ED2AA-F248-11E8-B48F-1D18A9856A87","first_name":"Barbara E"},{"id":"3C7F4840-F248-11E8-B48F-1D18A9856A87","first_name":"Christopher","last_name":"Pull","full_name":"Pull, Christopher","orcid":"0000-0003-1122-3982"},{"first_name":"Filip","full_name":"Naiser, Filip","last_name":"Naiser"},{"last_name":"Naderlinger","full_name":"Naderlinger, Elisabeth","first_name":"Elisabeth"},{"first_name":"Jiri","last_name":"Matas","full_name":"Matas, Jiri"},{"orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia"}],"title":"Early queen infection shapes developmental dynamics and induces long-term disease protection in incipient ant colonies","department":[{"_id":"SyCr"}],"abstract":[{"lang":"eng","text":"Infections early in life can have enduring effects on an organism’s development and immunity. In this study, we show that this equally applies to developing “superorganisms” – incipient social insect colonies. When we exposed newly mated Lasius niger ant queens to a low pathogen dose, their colonies grew more slowly than controls before winter, but reached similar sizes afterwards. Independent of exposure, queen hibernation survival improved when the ratio of pupae to workers was small. Queens that reared fewer pupae before worker emergence exhibited lower pathogen levels, indicating that high brood rearing efforts interfere with the ability of the queen’s immune system to suppress pathogen proliferation. Early-life queen pathogen-exposure also improved the immunocompetence of her worker offspring, as demonstrated by challenging the workers to the same pathogen a year later. Transgenerational transfer of the queen’s pathogen experience to her workforce can hence durably reduce the disease susceptibility of the whole superorganism."}],"oa_version":"Published Version","oa":1,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.7pvmcvdtj"}],"publisher":"Dryad","month":"10","year":"2021","day":"29","ec_funded":1,"license":"https://creativecommons.org/publicdomain/zero/1.0/","date_created":"2023-05-23T16:14:35Z","date_published":"2021-10-29T00:00:00Z","related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"10284"}]},"doi":"10.5061/DRYAD.7PVMCVDTJ"},{"_id":"10568","keyword":["ecology","evolution","behavior and systematics","trans-generational plasticity","genetic adaptation","local adaptation","phenotypic plasticity","Baltic Sea","climate change","salinity","syngnathids"],"status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","article_type":"original","ddc":["597"],"date_updated":"2023-08-17T06:27:22Z","department":[{"_id":"SyCr"}],"file_date_updated":"2021-12-20T10:44:20Z","oa_version":"Published Version","abstract":[{"lang":"eng","text":"Genetic adaptation and phenotypic plasticity facilitate the migration into new habitats and enable organisms to cope with a rapidly changing environment. In contrast to genetic adaptation that spans multiple generations as an evolutionary process, phenotypic plasticity allows acclimation within the life-time of an organism. Genetic adaptation and phenotypic plasticity are usually studied in isolation, however, only by including their interactive impact, we can understand acclimation and adaptation in nature. We aimed to explore the contribution of adaptation and plasticity in coping with an abiotic (salinity) and a biotic (Vibrio bacteria) stressor using six different populations of the broad-nosed pipefish Syngnathus typhle that originated from either high [14–17 Practical Salinity Unit (PSU)] or low (7–11 PSU) saline environments along the German coastline of the Baltic Sea. We exposed wild caught animals, to either high (15 PSU) or low (7 PSU) salinity, representing native and novel salinity conditions and allowed animals to mate. After male pregnancy, offspring was split and each half was exposed to one of the two salinities and infected with Vibrio alginolyticus bacteria that were evolved at either of the two salinities in a fully reciprocal design. We investigated life-history traits of fathers and expression of 47 target genes in mothers and offspring. Pregnant males originating from high salinity exposed to low salinity were highly susceptible to opportunistic fungi infections resulting in decreased offspring size and number. In contrast, no signs of fungal infection were identified in fathers originating from low saline conditions suggesting that genetic adaptation has the potential to overcome the challenges encountered at low salinity. Offspring from parents with low saline origin survived better at low salinity suggesting genetic adaptation to low salinity. In addition, gene expression analyses of juveniles indicated patterns of local adaptation, trans-generational plasticity and developmental plasticity. In conclusion, our study suggests that pipefish are locally adapted to the low salinity in their environment, however, they are retaining phenotypic plasticity, which allows them to also cope with ancestral salinity levels and prevailing pathogens."}],"intvolume":" 9","month":"03","scopus_import":"1","language":[{"iso":"eng"}],"file":[{"date_created":"2021-12-20T10:44:20Z","file_name":"2021_Frontiers_Goehlich.pdf","creator":"alisjak","date_updated":"2021-12-20T10:44:20Z","file_size":3175085,"file_id":"10572","checksum":"8d6e2b767bb0240a9b5a3a3555be51fd","success":1,"access_level":"open_access","relation":"main_file","content_type":"application/pdf"}],"publication_status":"published","publication_identifier":{"issn":["2296-701X"]},"volume":9,"article_number":"626442","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"ista":"Goehlich H, Sartoris L, Wagner K-S, Wendling CC, Roth O. 2021. Pipefish locally adapted to low salinity in the Baltic Sea retain phenotypic plasticity to cope with ancestral salinity levels. Frontiers in Ecology and Evolution. 9, 626442.","chicago":"Goehlich, Henry, Linda Sartoris, Kim-Sara Wagner, Carolin C. Wendling, and Olivia Roth. “Pipefish Locally Adapted to Low Salinity in the Baltic Sea Retain Phenotypic Plasticity to Cope with Ancestral Salinity Levels.” Frontiers in Ecology and Evolution. Frontiers Media, 2021. https://doi.org/10.3389/fevo.2021.626442.","apa":"Goehlich, H., Sartoris, L., Wagner, K.-S., Wendling, C. C., & Roth, O. (2021). Pipefish locally adapted to low salinity in the Baltic Sea retain phenotypic plasticity to cope with ancestral salinity levels. Frontiers in Ecology and Evolution. Frontiers Media. https://doi.org/10.3389/fevo.2021.626442","ama":"Goehlich H, Sartoris L, Wagner K-S, Wendling CC, Roth O. Pipefish locally adapted to low salinity in the Baltic Sea retain phenotypic plasticity to cope with ancestral salinity levels. Frontiers in Ecology and Evolution. 2021;9. doi:10.3389/fevo.2021.626442","ieee":"H. Goehlich, L. Sartoris, K.-S. Wagner, C. C. Wendling, and O. Roth, “Pipefish locally adapted to low salinity in the Baltic Sea retain phenotypic plasticity to cope with ancestral salinity levels,” Frontiers in Ecology and Evolution, vol. 9. Frontiers Media, 2021.","short":"H. Goehlich, L. Sartoris, K.-S. Wagner, C.C. Wendling, O. Roth, Frontiers in Ecology and Evolution 9 (2021).","mla":"Goehlich, Henry, et al. “Pipefish Locally Adapted to Low Salinity in the Baltic Sea Retain Phenotypic Plasticity to Cope with Ancestral Salinity Levels.” Frontiers in Ecology and Evolution, vol. 9, 626442, Frontiers Media, 2021, doi:10.3389/fevo.2021.626442."},"title":"Pipefish locally adapted to low salinity in the Baltic Sea retain phenotypic plasticity to cope with ancestral salinity levels","article_processing_charge":"No","external_id":{"isi":["000637736300001"]},"author":[{"first_name":"Henry","last_name":"Goehlich","full_name":"Goehlich, Henry"},{"first_name":"Linda","id":"2B9284CA-F248-11E8-B48F-1D18A9856A87","last_name":"Sartoris","full_name":"Sartoris, Linda"},{"first_name":"Kim-Sara","last_name":"Wagner","full_name":"Wagner, Kim-Sara"},{"first_name":"Carolin C.","last_name":"Wendling","full_name":"Wendling, Carolin C."},{"last_name":"Roth","full_name":"Roth, Olivia","first_name":"Olivia"}],"acknowledgement":"We are grateful for the help of Kristina Dauven, Andreas Ebner, Janina Röckner, and Paulina Urban for fish collection in the field and fish maintenance. Furthermore, we thank Fabian Wendt for setting up the aquaria system and Tatjana Liese, Paulina Urban, Jakob Gismann, and Thorsten Reusch for support with DNA extraction and analysis of pipefish population structure. The authors acknowledge support of Isabel Tanger, Agnes Piecyk, Jonas Müller, Grace Walls, Sebastian Albrecht, Julia Böge, and Julia Stefanschitz for their support in preparing cDNA and running of Fluidigm chips. A special thank goes to Diana Gill for general lab support, ordering materials and just being the good spirit of our molecular lab, to Till Bayer for bioinformatics support and to Melanie Heckwolf for fruitful discussion and feedback on the manuscript. HG is very grateful for inspirational office space with ocean view provided by Lisa Hentschel and family. This manuscript has been released as a pre-print at BIORXIV.","oa":1,"quality_controlled":"1","publisher":"Frontiers Media","publication":"Frontiers in Ecology and Evolution","day":"25","year":"2021","has_accepted_license":"1","isi":1,"date_created":"2021-12-20T07:53:19Z","date_published":"2021-03-25T00:00:00Z","doi":"10.3389/fevo.2021.626442"},{"_id":"10569","status":"public","article_type":"original","type":"journal_article","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"ddc":["573"],"date_updated":"2023-08-17T06:26:15Z","file_date_updated":"2021-12-20T10:14:14Z","department":[{"_id":"SyCr"}],"pmid":1,"oa_version":"Published Version","abstract":[{"lang":"eng","text":"For animals to survive until reproduction, it is crucial that juveniles successfully detect potential predators and respond with appropriate behavior. The recognition of cues originating from predators can be innate or learned. Cues of various modalities might be used alone or in multi-modal combinations to detect and distinguish predators but studies investigating multi-modal integration in predator avoidance are scarce. Here, we used wild, naive tadpoles of the Neotropical poison frog Allobates femoralis ( Boulenger, 1884) to test their reaction to cues with two modalities from two different sympatrically occurring potential predators: heterospecific predatory Dendrobates tinctorius tadpoles and dragonfly larvae. We presented A. femoralis tadpoles with olfactory or visual cues, or a combination of the two, and compared their reaction to a water control in a between-individual design. In our trials, A. femoralis tadpoles reacted to multi-modal stimuli (a combination of visual and chemical information) originating from dragonfly larvae with avoidance but showed no reaction to uni-modal cues or cues from heterospecific tadpoles. In addition, visual cues from conspecifics increased swimming activity while cues from predators had no effect on tadpole activity. Our results show that A. femoralis tadpoles can innately recognize some predators and probably need both visual and chemical information to effectively avoid them. This is the first study looking at anti-predator behavior in poison frog tadpoles. We discuss how parental care might influence the expression of predator avoidance responses in tadpoles."}],"month":"12","intvolume":" 224","file":[{"file_id":"10571","checksum":"75d13a5ec8e3b90e3bc02bd8a9c17eef","success":1,"content_type":"application/pdf","access_level":"open_access","relation":"main_file","date_created":"2021-12-20T10:14:14Z","file_name":"2021_JExpBio_Szabo.pdf","date_updated":"2021-12-20T10:14:14Z","file_size":607096,"creator":"cchlebak"}],"language":[{"iso":"eng"}],"publication_identifier":{"issn":["0022-0949"],"eissn":["1477-9145"]},"publication_status":"published","volume":224,"issue":"24","article_number":"jeb243647","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"mla":"Szabo, B., et al. “Naïve Poison Frog Tadpoles Use Bi-Modal Cues to Avoid Insect Predators but Not Heterospecific Predatory Tadpoles.” Journal of Experimental Biology, vol. 224, no. 24, jeb243647, The Company of Biologists, 2021, doi:10.1242/jeb.243647.","ama":"Szabo B, Mangione R, Rath M, et al. Naïve poison frog tadpoles use bi-modal cues to avoid insect predators but not heterospecific predatory tadpoles. Journal of Experimental Biology. 2021;224(24). doi:10.1242/jeb.243647","apa":"Szabo, B., Mangione, R., Rath, M., Pašukonis, A., Reber, S., Oh, J., … Ringler, E. (2021). Naïve poison frog tadpoles use bi-modal cues to avoid insect predators but not heterospecific predatory tadpoles. Journal of Experimental Biology. The Company of Biologists. https://doi.org/10.1242/jeb.243647","ieee":"B. Szabo et al., “Naïve poison frog tadpoles use bi-modal cues to avoid insect predators but not heterospecific predatory tadpoles,” Journal of Experimental Biology, vol. 224, no. 24. The Company of Biologists, 2021.","short":"B. Szabo, R. Mangione, M. Rath, A. Pašukonis, S. Reber, J. Oh, M. Ringler, E. Ringler, Journal of Experimental Biology 224 (2021).","chicago":"Szabo, B, R Mangione, M Rath, A Pašukonis, SA Reber, Jinook Oh, M Ringler, and E Ringler. “Naïve Poison Frog Tadpoles Use Bi-Modal Cues to Avoid Insect Predators but Not Heterospecific Predatory Tadpoles.” Journal of Experimental Biology. The Company of Biologists, 2021. https://doi.org/10.1242/jeb.243647.","ista":"Szabo B, Mangione R, Rath M, Pašukonis A, Reber S, Oh J, Ringler M, Ringler E. 2021. Naïve poison frog tadpoles use bi-modal cues to avoid insect predators but not heterospecific predatory tadpoles. Journal of Experimental Biology. 224(24), jeb243647."},"title":"Naïve poison frog tadpoles use bi-modal cues to avoid insect predators but not heterospecific predatory tadpoles","author":[{"last_name":"Szabo","full_name":"Szabo, B","first_name":"B"},{"full_name":"Mangione, R","last_name":"Mangione","first_name":"R"},{"last_name":"Rath","full_name":"Rath, M","first_name":"M"},{"full_name":"Pašukonis, A","last_name":"Pašukonis","first_name":"A"},{"first_name":"SA","full_name":"Reber, SA","last_name":"Reber"},{"first_name":"Jinook","id":"403169A4-080F-11EA-9993-BF3F3DDC885E","last_name":"Oh","full_name":"Oh, Jinook","orcid":"0000-0001-7425-2372"},{"first_name":"M","last_name":"Ringler","full_name":"Ringler, M"},{"last_name":"Ringler","full_name":"Ringler, E","first_name":"E"}],"article_processing_charge":"No","external_id":{"isi":["000738259300013"],"pmid":["34845497"]},"acknowledgement":"We are grateful to Véronique Helfer, Walter Hödl, Lisa Schretzmeyer and Julia Wotke, who assisted with fieldwork in French Guiana. This work was supported by the Austrian Science Fund (FWF) [P24788, T699 and P31518 to E.R.; P33728 to M.R.; J3827 to Thomas Bugnyar, Tecumseh Fitch and Ludwig Huber]; and by the Austrian Bundesministerium für Wissenschaft, Forschung und Wirtschaft [IS761001 to J.O. (Tecumseh Fitch, Thomas Bugnyar and Ludwig Huber)]. A.P. was supported by the European Union's Horizon 2020 research and innovation programme under the Marie Sklodowska-Curie grant agreement no. 835530. S.A.R. was supported by the HT faculty, Lund University. We thank the CNRS Nouragues Ecological Research Station, which benefited from the ‘Investissement d'Avenir’ grants managed by the Agence Nationale de la Recherche (AnaEE France ANR-11-INBS-0001; Labex CEBA ANR-10-LABX-25-01). Open access funding provided by University of Vienna. Deposited in PMC for immediate release.","publisher":"The Company of Biologists","quality_controlled":"1","oa":1,"day":"16","publication":"Journal of Experimental Biology","has_accepted_license":"1","isi":1,"year":"2021","doi":"10.1242/jeb.243647","date_published":"2021-12-16T00:00:00Z","date_created":"2021-12-20T07:54:22Z"},{"status":"public","type":"book_chapter","_id":"9096","editor":[{"last_name":"Starr","full_name":"Starr, C","first_name":"C"}],"title":"Parasites and Pathogens","department":[{"_id":"SyCr"}],"article_processing_charge":"No","author":[{"first_name":"Paul","full_name":"Schmid-Hempel, Paul","last_name":"Schmid-Hempel"},{"orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia M","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia M"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","date_updated":"2021-02-05T12:19:21Z","citation":{"chicago":"Schmid-Hempel, Paul, and Sylvia Cremer. “Parasites and Pathogens.” In Encyclopedia of Social Insects, edited by C Starr. Cham: Springer Nature, 2020. https://doi.org/10.1007/978-3-319-90306-4_94-1.","ista":"Schmid-Hempel P, Cremer S. 2020.Parasites and Pathogens. In: Encyclopedia of Social Insects. .","mla":"Schmid-Hempel, Paul, and Sylvia Cremer. “Parasites and Pathogens.” Encyclopedia of Social Insects, edited by C Starr, Springer Nature, 2020, doi:10.1007/978-3-319-90306-4_94-1.","apa":"Schmid-Hempel, P., & Cremer, S. (2020). Parasites and Pathogens. In C. Starr (Ed.), Encyclopedia of Social Insects. Cham: Springer Nature. https://doi.org/10.1007/978-3-319-90306-4_94-1","ama":"Schmid-Hempel P, Cremer S. Parasites and Pathogens. In: Starr C, ed. Encyclopedia of Social Insects. Cham: Springer Nature; 2020. doi:10.1007/978-3-319-90306-4_94-1","ieee":"P. Schmid-Hempel and S. Cremer, “Parasites and Pathogens,” in Encyclopedia of Social Insects, C. Starr, Ed. Cham: Springer Nature, 2020.","short":"P. Schmid-Hempel, S. Cremer, in:, C. Starr (Ed.), Encyclopedia of Social Insects, Springer Nature, Cham, 2020."},"place":"Cham","month":"02","quality_controlled":"1","publisher":"Springer Nature","oa_version":"None","date_created":"2021-02-05T12:15:18Z","doi":"10.1007/978-3-319-90306-4_94-1","date_published":"2020-02-22T00:00:00Z","language":[{"iso":"eng"}],"publication":"Encyclopedia of Social Insects","day":"22","publication_status":"published","year":"2020","publication_identifier":{"isbn":["9783319903064"]}},{"publication":"eLife","day":"23","year":"2020","isi":1,"has_accepted_license":"1","date_created":"2020-02-16T23:00:50Z","date_published":"2020-01-23T00:00:00Z","doi":"10.7554/eLife.52067","oa":1,"quality_controlled":"1","publisher":"eLife Sciences Publications","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","citation":{"ama":"Narasimhan M, Johnson AJ, Prizak R, et al. Evolutionarily unique mechanistic framework of clathrin-mediated endocytosis in plants. eLife. 2020;9. doi:10.7554/eLife.52067","apa":"Narasimhan, M., Johnson, A. J., Prizak, R., Kaufmann, W., Tan, S., Casillas Perez, B. E., & Friml, J. (2020). Evolutionarily unique mechanistic framework of clathrin-mediated endocytosis in plants. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.52067","ieee":"M. Narasimhan et al., “Evolutionarily unique mechanistic framework of clathrin-mediated endocytosis in plants,” eLife, vol. 9. eLife Sciences Publications, 2020.","short":"M. Narasimhan, A.J. Johnson, R. Prizak, W. Kaufmann, S. Tan, B.E. Casillas Perez, J. Friml, ELife 9 (2020).","mla":"Narasimhan, Madhumitha, et al. “Evolutionarily Unique Mechanistic Framework of Clathrin-Mediated Endocytosis in Plants.” ELife, vol. 9, e52067, eLife Sciences Publications, 2020, doi:10.7554/eLife.52067.","ista":"Narasimhan M, Johnson AJ, Prizak R, Kaufmann W, Tan S, Casillas Perez BE, Friml J. 2020. Evolutionarily unique mechanistic framework of clathrin-mediated endocytosis in plants. eLife. 9, e52067.","chicago":"Narasimhan, Madhumitha, Alexander J Johnson, Roshan Prizak, Walter Kaufmann, Shutang Tan, Barbara E Casillas Perez, and Jiří Friml. “Evolutionarily Unique Mechanistic Framework of Clathrin-Mediated Endocytosis in Plants.” ELife. eLife Sciences Publications, 2020. https://doi.org/10.7554/eLife.52067."},"title":"Evolutionarily unique mechanistic framework of clathrin-mediated endocytosis in plants","external_id":{"isi":["000514104100001"],"pmid":["31971511"]},"article_processing_charge":"No","author":[{"id":"44BF24D0-F248-11E8-B48F-1D18A9856A87","first_name":"Madhumitha","orcid":"0000-0002-8600-0671","full_name":"Narasimhan, Madhumitha","last_name":"Narasimhan"},{"full_name":"Johnson, Alexander J","orcid":"0000-0002-2739-8843","last_name":"Johnson","first_name":"Alexander J","id":"46A62C3A-F248-11E8-B48F-1D18A9856A87"},{"id":"4456104E-F248-11E8-B48F-1D18A9856A87","first_name":"Roshan","full_name":"Prizak, Roshan","last_name":"Prizak"},{"first_name":"Walter","id":"3F99E422-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9735-5315","full_name":"Kaufmann, Walter","last_name":"Kaufmann"},{"last_name":"Tan","orcid":"0000-0002-0471-8285","full_name":"Tan, Shutang","id":"2DE75584-F248-11E8-B48F-1D18A9856A87","first_name":"Shutang"},{"last_name":"Casillas Perez","full_name":"Casillas Perez, Barbara E","first_name":"Barbara E","id":"351ED2AA-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří","last_name":"Friml","first_name":"Jiří","id":"4159519E-F248-11E8-B48F-1D18A9856A87"}],"article_number":"e52067","project":[{"call_identifier":"H2020","_id":"261099A6-B435-11E9-9278-68D0E5697425","name":"Tracing Evolution of Auxin Transport and Polarity in Plants","grant_number":"742985"},{"call_identifier":"FWF","_id":"26538374-B435-11E9-9278-68D0E5697425","name":"Molecular mechanisms of endocytic cargo recognition in plants","grant_number":"I03630"}],"language":[{"iso":"eng"}],"file":[{"content_type":"application/pdf","relation":"main_file","access_level":"open_access","checksum":"2052daa4be5019534f3a42f200a09f32","file_id":"7494","file_size":7247468,"date_updated":"2020-07-14T12:47:59Z","creator":"dernst","file_name":"2020_eLife_Narasimhan.pdf","date_created":"2020-02-18T07:21:16Z"}],"publication_status":"published","publication_identifier":{"eissn":["2050-084X"]},"ec_funded":1,"volume":9,"oa_version":"Published Version","pmid":1,"acknowledged_ssus":[{"_id":"LifeSc"},{"_id":"Bio"},{"_id":"EM-Fac"}],"abstract":[{"lang":"eng","text":"In plants, clathrin mediated endocytosis (CME) represents the major route for cargo internalisation from the cell surface. It has been assumed to operate in an evolutionary conserved manner as in yeast and animals. Here we report characterisation of ultrastructure, dynamics and mechanisms of plant CME as allowed by our advancement in electron microscopy and quantitative live imaging techniques. Arabidopsis CME appears to follow the constant curvature model and the bona fide CME population generates vesicles of a predominantly hexagonal-basket type; larger and with faster kinetics than in other models. Contrary to the existing paradigm, actin is dispensable for CME events at the plasma membrane but plays a unique role in collecting endocytic vesicles, sorting of internalised cargos and directional endosome movement that itself actively promote CME events. Internalized vesicles display a strongly delayed and sequential uncoating. These unique features highlight the independent evolution of the plant CME mechanism during the autonomous rise of multicellularity in eukaryotes."}],"intvolume":" 9","month":"01","scopus_import":"1","ddc":["570","580"],"date_updated":"2023-08-18T06:33:07Z","department":[{"_id":"JiFr"},{"_id":"GaTk"},{"_id":"EM-Fac"},{"_id":"SyCr"}],"file_date_updated":"2020-07-14T12:47:59Z","_id":"7490","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_type":"original","type":"journal_article"},{"month":"03","intvolume":" 23","scopus_import":"1","oa_version":"Published Version","acknowledged_ssus":[{"_id":"LifeSc"}],"abstract":[{"text":"Coinfections with multiple pathogens can result in complex within‐host dynamics affecting virulence and transmission. While multiple infections are intensively studied in solitary hosts, it is so far unresolved how social host interactions interfere with pathogen competition, and if this depends on coinfection diversity. We studied how the collective disease defences of ants – their social immunity – influence pathogen competition in coinfections of same or different fungal pathogen species. Social immunity reduced virulence for all pathogen combinations, but interfered with spore production only in different‐species coinfections. Here, it decreased overall pathogen sporulation success while increasing co‐sporulation on individual cadavers and maintaining a higher pathogen diversity at the community level. Mathematical modelling revealed that host sanitary care alone can modulate competitive outcomes between pathogens, giving advantage to fast‐germinating, thus less grooming‐sensitive ones. Host social interactions can hence modulate infection dynamics in coinfected group members, thereby altering pathogen communities at the host level and population level.","lang":"eng"}],"related_material":{"record":[{"relation":"research_data","id":"13060","status":"public"}],"link":[{"description":"News on IST Homepage","url":"https://ist.ac.at/en/news/social-ants-shapes-disease-outcome/","relation":"press_release"}]},"issue":"3","volume":23,"license":"https://creativecommons.org/licenses/by-nc/4.0/","ec_funded":1,"file":[{"file_name":"2020_EcologyLetters_Milutinovic.pdf","date_created":"2020-11-19T11:27:10Z","creator":"dernst","file_size":561749,"date_updated":"2020-11-19T11:27:10Z","success":1,"checksum":"0cd8be386fa219db02845b7c3991ce04","file_id":"8776","relation":"main_file","access_level":"open_access","content_type":"application/pdf"}],"language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1461-0248"],"issn":["1461-023X"]},"publication_status":"published","status":"public","type":"journal_article","article_type":"letter_note","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","short":"CC BY-NC (4.0)"},"_id":"7343","department":[{"_id":"SyCr"},{"_id":"KrCh"}],"file_date_updated":"2020-11-19T11:27:10Z","ddc":["570"],"date_updated":"2023-09-05T16:04:49Z","quality_controlled":"1","publisher":"Wiley","oa":1,"acknowledgement":"We thank Bernhardt Steinwender and Jorgen Eilenberg for the fungal strains, Xavier Espadaler, Mireia Diaz, Christiane Wanke, Lumi Viljakainen and the Social Immunity Team at IST Austria, for help with ant collection, and Wanda Gorecka and Gertraud Stift of the IST Austria Life Science Facility for technical support. We are thankful to Dieter Ebert for input at all stages of the project, Roger Mundry for statistical advice, Hinrich Schulenburg, Paul Schmid-Hempel, Yuko\r\nUlrich and Joachim Kurtz for project discussion, Bor Kavcic for advice on growth curves, Marcus Roper for advice on modelling work and comments on the manuscript, as well as Marjon de Vos, Weini Huang and the Social Immunity Team for comments on the manuscript.\r\nThis study was funded by the German Research Foundation (DFG) within the Priority Programme 1399 Host-parasite Coevolution (CR 118/3 to S.C.) and the People Programme\r\n(Marie Curie Actions) of the European Union’s Seventh Framework Programme (FP7/2007-2013) under REA grant agreement no 291734 (ISTFELLOW to B.M.). ","date_published":"2020-03-01T00:00:00Z","doi":"10.1111/ele.13458","date_created":"2020-01-20T13:32:12Z","page":"565-574","day":"01","publication":"Ecology Letters","isi":1,"has_accepted_license":"1","year":"2020","project":[{"name":"International IST Postdoc Fellowship Programme","grant_number":"291734","call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425"},{"_id":"25DAF0B2-B435-11E9-9278-68D0E5697425","grant_number":"CR-118/3-1","name":"Host-Parasite Coevolution"}],"title":"Social immunity modulates competition between coinfecting pathogens","author":[{"first_name":"Barbara","id":"2CDC32B8-F248-11E8-B48F-1D18A9856A87","full_name":"Milutinovic, Barbara","orcid":"0000-0002-8214-4758","last_name":"Milutinovic"},{"last_name":"Stock","full_name":"Stock, Miriam","first_name":"Miriam","id":"42462816-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Grasse, Anna V","last_name":"Grasse","first_name":"Anna V","id":"406F989C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Naderlinger","full_name":"Naderlinger, Elisabeth","first_name":"Elisabeth","id":"31757262-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Hilbe","full_name":"Hilbe, Christian","orcid":"0000-0001-5116-955X","first_name":"Christian","id":"2FDF8F3C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868","last_name":"Cremer","first_name":"Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"}],"article_processing_charge":"Yes (via OA deal)","external_id":{"isi":["000507515900001"]},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"ista":"Milutinovic B, Stock M, Grasse AV, Naderlinger E, Hilbe C, Cremer S. 2020. Social immunity modulates competition between coinfecting pathogens. Ecology Letters. 23(3), 565–574.","chicago":"Milutinovic, Barbara, Miriam Stock, Anna V Grasse, Elisabeth Naderlinger, Christian Hilbe, and Sylvia Cremer. “Social Immunity Modulates Competition between Coinfecting Pathogens.” Ecology Letters. Wiley, 2020. https://doi.org/10.1111/ele.13458.","ama":"Milutinovic B, Stock M, Grasse AV, Naderlinger E, Hilbe C, Cremer S. Social immunity modulates competition between coinfecting pathogens. Ecology Letters. 2020;23(3):565-574. doi:10.1111/ele.13458","apa":"Milutinovic, B., Stock, M., Grasse, A. V., Naderlinger, E., Hilbe, C., & Cremer, S. (2020). Social immunity modulates competition between coinfecting pathogens. Ecology Letters. Wiley. https://doi.org/10.1111/ele.13458","ieee":"B. Milutinovic, M. Stock, A. V. Grasse, E. Naderlinger, C. Hilbe, and S. Cremer, “Social immunity modulates competition between coinfecting pathogens,” Ecology Letters, vol. 23, no. 3. Wiley, pp. 565–574, 2020.","short":"B. Milutinovic, M. Stock, A.V. Grasse, E. Naderlinger, C. Hilbe, S. Cremer, Ecology Letters 23 (2020) 565–574.","mla":"Milutinovic, Barbara, et al. “Social Immunity Modulates Competition between Coinfecting Pathogens.” Ecology Letters, vol. 23, no. 3, Wiley, 2020, pp. 565–74, doi:10.1111/ele.13458."}},{"author":[{"last_name":"Milutinovic","full_name":"Milutinovic, Barbara","orcid":"0000-0002-8214-4758","first_name":"Barbara","id":"2CDC32B8-F248-11E8-B48F-1D18A9856A87"},{"id":"42462816-F248-11E8-B48F-1D18A9856A87","first_name":"Miriam","last_name":"Stock","full_name":"Stock, Miriam"},{"last_name":"Grasse","full_name":"Grasse, Anna V","first_name":"Anna V","id":"406F989C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Naderlinger, Elisabeth","last_name":"Naderlinger","first_name":"Elisabeth","id":"31757262-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-5116-955X","full_name":"Hilbe, Christian","last_name":"Hilbe","first_name":"Christian","id":"2FDF8F3C-F248-11E8-B48F-1D18A9856A87"},{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia","last_name":"Cremer","orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia"}],"article_processing_charge":"No","department":[{"_id":"SyCr"},{"_id":"KrCh"}],"title":"Social immunity modulates competition between coinfecting pathogens","date_updated":"2023-09-05T16:04:48Z","citation":{"short":"B. Milutinovic, M. Stock, A.V. Grasse, E. Naderlinger, C. Hilbe, S. Cremer, (2020).","ieee":"B. Milutinovic, M. Stock, A. V. Grasse, E. Naderlinger, C. Hilbe, and S. Cremer, “Social immunity modulates competition between coinfecting pathogens.” Dryad, 2020.","ama":"Milutinovic B, Stock M, Grasse AV, Naderlinger E, Hilbe C, Cremer S. Social immunity modulates competition between coinfecting pathogens. 2020. doi:10.5061/DRYAD.CRJDFN318","apa":"Milutinovic, B., Stock, M., Grasse, A. V., Naderlinger, E., Hilbe, C., & Cremer, S. (2020). Social immunity modulates competition between coinfecting pathogens. Dryad. https://doi.org/10.5061/DRYAD.CRJDFN318","mla":"Milutinovic, Barbara, et al. Social Immunity Modulates Competition between Coinfecting Pathogens. Dryad, 2020, doi:10.5061/DRYAD.CRJDFN318.","ista":"Milutinovic B, Stock M, Grasse AV, Naderlinger E, Hilbe C, Cremer S. 2020. Social immunity modulates competition between coinfecting pathogens, Dryad, 10.5061/DRYAD.CRJDFN318.","chicago":"Milutinovic, Barbara, Miriam Stock, Anna V Grasse, Elisabeth Naderlinger, Christian Hilbe, and Sylvia Cremer. “Social Immunity Modulates Competition between Coinfecting Pathogens.” Dryad, 2020. https://doi.org/10.5061/DRYAD.CRJDFN318."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["570"],"type":"research_data_reference","tmp":{"image":"/images/cc_0.png","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","name":"Creative Commons Public Domain Dedication (CC0 1.0)","short":"CC0 (1.0)"},"status":"public","_id":"13060","date_published":"2020-12-19T00:00:00Z","related_material":{"record":[{"status":"public","id":"7343","relation":"used_in_publication"}]},"doi":"10.5061/DRYAD.CRJDFN318","date_created":"2023-05-23T16:11:22Z","year":"2020","day":"19","publisher":"Dryad","main_file_link":[{"url":"https://doi.org/10.5061/dryad.crjdfn318","open_access":"1"}],"oa":1,"month":"12","abstract":[{"lang":"eng","text":"Coinfections with multiple pathogens can result in complex within-host dynamics affecting virulence and transmission. Whilst multiple infections are intensively studied in solitary hosts, it is so far unresolved how social host interactions interfere with pathogen competition, and if this depends on coinfection diversity. We studied how the collective disease defenses of ants – their social immunity – influence pathogen competition in coinfections of same or different fungal pathogen species. Social immunity reduced virulence for all pathogen combinations, but interfered with spore production only in different-species coinfections. Here, it decreased overall pathogen sporulation success, whilst simultaneously increasing co-sporulation on individual cadavers and maintaining a higher pathogen diversity at the community-level. Mathematical modeling revealed that host sanitary care alone can modulate competitive outcomes between pathogens, giving advantage to fast-germinating, thus less grooming-sensitive ones. Host social interactions can hence modulate infection dynamics in coinfected group members, thereby altering pathogen communities at the host- and population-level."}],"oa_version":"Published Version"},{"abstract":[{"lang":"eng","text":" Hosts can alter their strategy towards pathogens during their lifetime; that is, they can show phenotypic plasticity in immunity or life history. Immune priming is one such example, where a previous encounter with a pathogen confers enhanced protection upon secondary challenge, resulting in reduced pathogen load (i.e., resistance) and improved host survival. However, an initial encounter might also enhance tolerance, particularly to less virulent opportunistic pathogens that establish persistent infections. In this scenario, individuals are better able to reduce the negative fecundity consequences that result from a high pathogen burden. Finally, previous exposure may also lead to life‐history adjustments, such as terminal investment into reproduction.\r\n Using different Drosophila melanogaster host genotypes and two bacterial pathogens, Lactococcus lactis and Pseudomonas entomophila, we tested whether previous exposure results in resistance or tolerance and whether it modifies immune gene expression during an acute‐phase infection (one day post‐challenge). We then asked whether previous pathogen exposure affects chronic‐phase pathogen persistence and longer‐term survival (28 days post‐challenge).\r\n We predicted that previous exposure would increase host resistance to an early stage bacterial infection while it might come at a cost to host fecundity tolerance. We reasoned that resistance would be due in part to stronger immune gene expression after challenge. We expected that previous exposure would improve long‐term survival, that it would reduce infection persistence, and we expected to find genetic variation in these responses.\r\n We found that previous exposure to P. entomophila weakened host resistance to a second infection independent of genotype and had no effect on immune gene expression. Fecundity tolerance showed genotypic variation but was not influenced by previous exposure. However, L. lactis persisted as a chronic infection, whereas survivors cleared the more pathogenic P. entomophila infection.\r\n To our knowledge, this is the first study that addresses host tolerance to bacteria in relation to previous exposure, taking a multi‐faceted approach to address the topic. Our results suggest that previous exposure comes with transient costs to resistance during the early stage of infection in this host–pathogen system and that infection persistence may be bacterium‐specific.\r\n"}],"oa_version":"Published Version","scopus_import":"1","intvolume":" 88","month":"04","publication_status":"published","publication_identifier":{"eissn":["13652656"],"issn":["00218790"]},"language":[{"iso":"eng"}],"file":[{"file_id":"6107","checksum":"405cde15120de26018b3bd0dfa29986c","content_type":"application/pdf","access_level":"open_access","relation":"main_file","date_created":"2019-03-18T07:43:06Z","file_name":"2019_JournalAnimalEcology_Kutzer.pdf","date_updated":"2020-07-14T12:47:19Z","file_size":1460662,"creator":"dernst"}],"ec_funded":1,"volume":88,"related_material":{"record":[{"relation":"research_data","status":"public","id":"9806"}]},"issue":"4","_id":"6105","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"article_type":"original","type":"journal_article","status":"public","date_updated":"2023-08-25T08:04:53Z","ddc":["570"],"department":[{"_id":"SyCr"}],"file_date_updated":"2020-07-14T12:47:19Z","oa":1,"publisher":"Wiley","quality_controlled":"1","year":"2019","has_accepted_license":"1","isi":1,"publication":"Journal of Animal Ecology","day":"01","page":"566-578","date_created":"2019-03-17T22:59:15Z","doi":"10.1111/1365-2656.12953","date_published":"2019-04-01T00:00:00Z","project":[{"call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","name":"International IST Postdoc Fellowship Programme","grant_number":"291734"}],"citation":{"ista":"Kutzer M, Kurtz J, Armitage SAO. 2019. A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance. Journal of Animal Ecology. 88(4), 566–578.","chicago":"Kutzer, Megan, Joachim Kurtz, and Sophie A.O. Armitage. “A Multi-Faceted Approach Testing the Effects of Previous Bacterial Exposure on Resistance and Tolerance.” Journal of Animal Ecology. Wiley, 2019. https://doi.org/10.1111/1365-2656.12953.","ieee":"M. Kutzer, J. Kurtz, and S. A. O. Armitage, “A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance,” Journal of Animal Ecology, vol. 88, no. 4. Wiley, pp. 566–578, 2019.","short":"M. Kutzer, J. Kurtz, S.A.O. Armitage, Journal of Animal Ecology 88 (2019) 566–578.","ama":"Kutzer M, Kurtz J, Armitage SAO. A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance. Journal of Animal Ecology. 2019;88(4):566-578. doi:10.1111/1365-2656.12953","apa":"Kutzer, M., Kurtz, J., & Armitage, S. A. O. (2019). A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance. Journal of Animal Ecology. Wiley. https://doi.org/10.1111/1365-2656.12953","mla":"Kutzer, Megan, et al. “A Multi-Faceted Approach Testing the Effects of Previous Bacterial Exposure on Resistance and Tolerance.” Journal of Animal Ecology, vol. 88, no. 4, Wiley, 2019, pp. 566–78, doi:10.1111/1365-2656.12953."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","external_id":{"isi":["000467994800007"]},"article_processing_charge":"No","author":[{"last_name":"Kutzer","orcid":"0000-0002-8696-6978","full_name":"Kutzer, Megan","id":"29D0B332-F248-11E8-B48F-1D18A9856A87","first_name":"Megan"},{"first_name":"Joachim","last_name":"Kurtz","full_name":"Kurtz, Joachim"},{"first_name":"Sophie A.O.","last_name":"Armitage","full_name":"Armitage, Sophie A.O."}],"title":"A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance"},{"related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"6105"}]},"doi":"10.5061/dryad.9kj41f0","date_published":"2019-02-05T00:00:00Z","date_created":"2021-08-06T12:06:40Z","year":"2019","day":"05","publisher":"Dryad","main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.9kj41f0"}],"oa":1,"month":"02","abstract":[{"lang":"eng","text":"1. Hosts can alter their strategy towards pathogens during their lifetime, i.e., they can show phenotypic plasticity in immunity or life history. Immune priming is one such example, where a previous encounter with a pathogen confers enhanced protection upon secondary challenge, resulting in reduced pathogen load (i.e. resistance) and improved host survival. However, an initial encounter might also enhance tolerance, particularly to less virulent opportunistic pathogens that establish persistent infections. In this scenario, individuals are better able to reduce the negative fitness consequences that result from a high pathogen load. Finally, previous exposure may also lead to life history adjustments, such as terminal investment into reproduction. 2. Using different Drosophila melanogaster host genotypes and two bacterial pathogens, Lactococcus lactis and Pseudomonas entomophila, we tested if previous exposure results in resistance or tolerance and whether it modifies immune gene expression during an acute-phase infection (one day post-challenge). We then asked if previous pathogen exposure affects chronic-phase pathogen persistence and longer-term survival (28 days post-challenge). 3. We predicted that previous exposure would increase host resistance to an early stage bacterial infection while it might come at a cost to host fecundity tolerance. We reasoned that resistance would be due in part to stronger immune gene expression after challenge. We expected that previous exposure would improve long-term survival, that it would reduce infection persistence, and we expected to find genetic variation in these responses. 4. We found that previous exposure to P. entomophila weakened host resistance to a second infection independent of genotype and had no effect on immune gene expression. Fecundity tolerance showed genotypic variation but was not influenced by previous exposure. However, L. lactis persisted as a chronic infection, whereas survivors cleared the more pathogenic P. entomophila infection. 5. To our knowledge, this is the first study that addresses host tolerance to bacteria in relation to previous exposure, taking a multi-faceted approach to address the topic. Our results suggest that previous exposure comes with transient costs to resistance during the early stage of infection in this host-pathogen system and that infection persistence may be bacterium-specific."}],"oa_version":"Published Version","author":[{"first_name":"Megan","id":"29D0B332-F248-11E8-B48F-1D18A9856A87","full_name":"Kutzer, Megan","orcid":"0000-0002-8696-6978","last_name":"Kutzer"},{"last_name":"Kurtz","full_name":"Kurtz, Joachim","first_name":"Joachim"},{"full_name":"Armitage, Sophie A.O.","last_name":"Armitage","first_name":"Sophie A.O."}],"article_processing_charge":"No","title":"Data from: A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance","department":[{"_id":"SyCr"}],"citation":{"mla":"Kutzer, Megan, et al. Data from: A Multi-Faceted Approach Testing the Effects of Previous Bacterial Exposure on Resistance and Tolerance. Dryad, 2019, doi:10.5061/dryad.9kj41f0.","ama":"Kutzer M, Kurtz J, Armitage SAO. Data from: A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance. 2019. doi:10.5061/dryad.9kj41f0","apa":"Kutzer, M., Kurtz, J., & Armitage, S. A. O. (2019). Data from: A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance. Dryad. https://doi.org/10.5061/dryad.9kj41f0","ieee":"M. Kutzer, J. Kurtz, and S. A. O. Armitage, “Data from: A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance.” Dryad, 2019.","short":"M. Kutzer, J. Kurtz, S.A.O. Armitage, (2019).","chicago":"Kutzer, Megan, Joachim Kurtz, and Sophie A.O. Armitage. “Data from: A Multi-Faceted Approach Testing the Effects of Previous Bacterial Exposure on Resistance and Tolerance.” Dryad, 2019. https://doi.org/10.5061/dryad.9kj41f0.","ista":"Kutzer M, Kurtz J, Armitage SAO. 2019. Data from: A multi-faceted approach testing the effects of previous bacterial exposure on resistance and tolerance, Dryad, 10.5061/dryad.9kj41f0."},"date_updated":"2023-08-25T08:04:52Z","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","type":"research_data_reference","status":"public","_id":"9806"},{"oa_version":"None","abstract":[{"text":"Ant invasions are often harmful to native species communities. Their pathogens and host disease defense mechanisms may be one component of their devastating success. First, they can introduce harmful diseases to their competitors in the introduced range, to which they themselves are tolerant. Second, their supercolonial social structure of huge multi-queen nest networks means that they will harbor a broad pathogen spectrum and high pathogen load while remaining resilient, unlike the smaller, territorial colonies of the native species. Thus, it is likely that invasive ants act as a disease reservoir, promoting their competitive advantage and invasive success.","lang":"eng"}],"intvolume":" 33","month":"06","quality_controlled":"1","publisher":"Elsevier","scopus_import":"1","language":[{"iso":"eng"}],"publication":"Current Opinion in Insect Science","day":"01","year":"2019","publication_status":"published","publication_identifier":{"issn":["22145745"],"eissn":["22145753"]},"isi":1,"date_created":"2019-05-13T07:58:36Z","doi":"10.1016/j.cois.2019.03.011","date_published":"2019-06-01T00:00:00Z","volume":33,"page":"63-68","_id":"6415","status":"public","type":"journal_article","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","date_updated":"2023-08-25T10:31:31Z","citation":{"ama":"Cremer S. Pathogens and disease defense of invasive ants. Current Opinion in Insect Science. 2019;33:63-68. doi:10.1016/j.cois.2019.03.011","apa":"Cremer, S. (2019). Pathogens and disease defense of invasive ants. Current Opinion in Insect Science. Elsevier. https://doi.org/10.1016/j.cois.2019.03.011","ieee":"S. Cremer, “Pathogens and disease defense of invasive ants,” Current Opinion in Insect Science, vol. 33. Elsevier, pp. 63–68, 2019.","short":"S. Cremer, Current Opinion in Insect Science 33 (2019) 63–68.","mla":"Cremer, Sylvia. “Pathogens and Disease Defense of Invasive Ants.” Current Opinion in Insect Science, vol. 33, Elsevier, 2019, pp. 63–68, doi:10.1016/j.cois.2019.03.011.","ista":"Cremer S. 2019. Pathogens and disease defense of invasive ants. Current Opinion in Insect Science. 33, 63–68.","chicago":"Cremer, Sylvia. “Pathogens and Disease Defense of Invasive Ants.” Current Opinion in Insect Science. Elsevier, 2019. https://doi.org/10.1016/j.cois.2019.03.011."},"department":[{"_id":"SyCr"}],"title":"Pathogens and disease defense of invasive ants","external_id":{"isi":["000477666000012"]},"article_processing_charge":"No","author":[{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia","last_name":"Cremer","full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868"}]},{"author":[{"full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia"}],"article_processing_charge":"No","external_id":{"isi":["000470902000023"],"pmid":["31163158"]},"title":"Social immunity in insects","citation":{"mla":"Cremer, Sylvia. “Social Immunity in Insects.” Current Biology, vol. 29, no. 11, Elsevier, 2019, pp. R458–63, doi:10.1016/j.cub.2019.03.035.","short":"S. Cremer, Current Biology 29 (2019) R458–R463.","ieee":"S. Cremer, “Social immunity in insects,” Current Biology, vol. 29, no. 11. Elsevier, pp. R458–R463, 2019.","ama":"Cremer S. Social immunity in insects. Current Biology. 2019;29(11):R458-R463. doi:10.1016/j.cub.2019.03.035","apa":"Cremer, S. (2019). Social immunity in insects. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2019.03.035","chicago":"Cremer, Sylvia. “Social Immunity in Insects.” Current Biology. Elsevier, 2019. https://doi.org/10.1016/j.cub.2019.03.035.","ista":"Cremer S. 2019. Social immunity in insects. Current Biology. 29(11), R458–R463."},"user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","page":"R458-R463","doi":"10.1016/j.cub.2019.03.035","date_published":"2019-06-03T00:00:00Z","date_created":"2019-06-09T21:59:10Z","isi":1,"year":"2019","day":"03","publication":"Current Biology","quality_controlled":"1","publisher":"Elsevier","oa":1,"department":[{"_id":"SyCr"}],"date_updated":"2023-08-28T09:38:00Z","article_type":"original","type":"journal_article","status":"public","_id":"6552","issue":"11","volume":29,"publication_identifier":{"issn":["09609822"]},"publication_status":"published","language":[{"iso":"eng"}],"scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.cub.2019.03.035"}],"month":"06","intvolume":" 29","abstract":[{"text":"When animals become sick, infected cells and an armada of activated immune cells attempt to eliminate the pathogen from the body. Once infectious particles have breached the body's physical barriers of the skin or gut lining, an initially local response quickly escalates into a systemic response, attracting mobile immune cells to the site of infection. These cells complement the initial, unspecific defense with a more specialized, targeted response. This can also provide long-term immune memory and protection against future infection. The cell-autonomous defenses of the infected cells are thus aided by the actions of recruited immune cells. These specialized cells are the most mobile cells in the body, constantly patrolling through the otherwise static tissue to detect incoming pathogens. Such constant immune surveillance means infections are noticed immediately and can be rapidly cleared from the body. Some immune cells also remove infected cells that have succumbed to infection. All this prevents pathogen replication and spread to healthy tissues. Although this may involve the sacrifice of some somatic tissue, this is typically replaced quickly. Particular care is, however, given to the reproductive organs, which should always remain disease free (immune privilege). ","lang":"eng"}],"pmid":1,"oa_version":"Published Version"},{"editor":[{"first_name":"Jae","full_name":"Choe, Jae","last_name":"Choe"}],"department":[{"_id":"SyCr"}],"title":"Social immunity","author":[{"last_name":"Cremer","orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia"},{"id":"29D0B332-F248-11E8-B48F-1D18A9856A87","first_name":"Megan","full_name":"Kutzer, Megan","orcid":"0000-0002-8696-6978","last_name":"Kutzer"}],"external_id":{"isi":["000248989500026"]},"article_processing_charge":"No","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"mla":"Cremer, Sylvia, and Megan Kutzer. “Social Immunity.” Encyclopedia of Animal Behavior, edited by Jae Choe, 2nd ed., Elsevier, 2019, pp. 747–55, doi:10.1016/B978-0-12-809633-8.90721-0.","ieee":"S. Cremer and M. Kutzer, “Social immunity,” in Encyclopedia of Animal Behavior, 2nd ed., J. Choe, Ed. Elsevier, 2019, pp. 747–755.","short":"S. Cremer, M. Kutzer, in:, J. Choe (Ed.), Encyclopedia of Animal Behavior, 2nd ed., Elsevier, 2019, pp. 747–755.","ama":"Cremer S, Kutzer M. Social immunity. In: Choe J, ed. Encyclopedia of Animal Behavior. 2nd ed. Elsevier; 2019:747-755. doi:10.1016/B978-0-12-809633-8.90721-0","apa":"Cremer, S., & Kutzer, M. (2019). Social immunity. In J. Choe (Ed.), Encyclopedia of Animal Behavior (2nd ed., pp. 747–755). Elsevier. https://doi.org/10.1016/B978-0-12-809633-8.90721-0","chicago":"Cremer, Sylvia, and Megan Kutzer. “Social Immunity.” In Encyclopedia of Animal Behavior, edited by Jae Choe, 2nd ed., 747–55. Elsevier, 2019. https://doi.org/10.1016/B978-0-12-809633-8.90721-0.","ista":"Cremer S, Kutzer M. 2019.Social immunity. In: Encyclopedia of Animal Behavior. , 747–755."},"date_updated":"2023-09-08T11:12:04Z","status":"public","type":"book_chapter","_id":"7513","date_published":"2019-02-06T00:00:00Z","doi":"10.1016/B978-0-12-809633-8.90721-0","date_created":"2020-02-23T23:00:36Z","page":"747-755","day":"06","publication":"Encyclopedia of Animal Behavior","language":[{"iso":"eng"}],"isi":1,"publication_identifier":{"isbn":["9780128132517"],"eisbn":["9780128132524"]},"publication_status":"published","year":"2019","month":"02","scopus_import":"1","quality_controlled":"1","publisher":"Elsevier","edition":"2","oa_version":"None","abstract":[{"lang":"eng","text":"Social insects (i.e., ants, termites and the social bees and wasps) protect their colonies from disease using a combination of individual immunity and collectively performed defenses, termed social immunity. The first line of social immune defense is sanitary care, which is performed by colony members to protect their pathogen-exposed nestmates from developing an infection. If sanitary care fails and an infection becomes established, a second line of social immune defense is deployed to stop disease transmission within the colony and to protect the valuable queens, which together with the males are the reproductive individuals of the colony. Insect colonies are separated into these reproductive individuals and the sterile worker force, forming a superorganismal reproductive unit reminiscent of the differentiated germline and soma in a multicellular organism. Ultimately, the social immune response preserves the germline of the superorganism insect colony and increases overall fitness of the colony in case of disease. "}]},{"publication_identifier":{"issn":["2663-337X"]},"degree_awarded":"PhD","publication_status":"published","file":[{"date_created":"2019-05-13T09:16:20Z","file_name":"tesisDoctoradoBC.pdf","date_updated":"2021-02-11T11:17:15Z","file_size":3895187,"creator":"casillas","checksum":"6daf2d2086111aa8fd3fbc919a3e2833","file_id":"6438","embargo":"2020-05-08","content_type":"application/pdf","access_level":"open_access","relation":"main_file"},{"file_name":"tesisDoctoradoBC.zip","date_created":"2019-05-13T09:16:20Z","file_size":7365118,"date_updated":"2020-07-14T12:47:30Z","creator":"casillas","file_id":"6439","checksum":"3d221aaff7559a7060230a1ff610594f","embargo_to":"open_access","content_type":"application/zip","relation":"source_file","access_level":"closed"}],"language":[{"iso":"eng"}],"related_material":{"record":[{"relation":"part_of_dissertation","status":"public","id":"1999"}]},"ec_funded":1,"acknowledged_ssus":[{"_id":"Bio"},{"_id":"ScienComp"},{"_id":"M-Shop"},{"_id":"LifeSc"}],"abstract":[{"lang":"eng","text":"Social insect colonies tend to have numerous members which function together like a single organism in such harmony that the term ``super-organism'' is often used. In this analogy the reproductive caste is analogous to the primordial germ\r\ncells of a metazoan, while the sterile worker caste corresponds to somatic cells. The worker castes, like tissues, are\r\nin charge of all functions of a living being, besides reproduction. The establishment of new super-organismal units\r\n(i.e. new colonies) is accomplished by the co-dependent castes. The term oftentimes goes beyond a metaphor. We invoke it when we speak about the metabolic rate, thermoregulation, nutrient regulation and gas exchange of a social insect colony. Furthermore, we assert that the super-organism has an immune system, and benefits from ``social immunity''.\r\n\r\nSocial immunity was first summoned by evolutionary biologists to resolve the apparent discrepancy between the expected high frequency of disease outbreak amongst numerous, closely related tightly-interacting hosts, living in stable and microbially-rich environments, against the exceptionally scarce epidemic accounts in natural populations. Social\r\nimmunity comprises a multi-layer assembly of behaviours which have evolved to effectively keep the pathogenic enemies of a colony at bay. The field of social immunity has drawn interest, as it becomes increasingly urgent to stop\r\nthe collapse of pollinator species and curb the growth of invasive pests. In the past decade, several mechanisms of\r\nsocial immune responses have been dissected, but many more questions remain open.\r\n\r\nI present my work in two experimental chapters. In the first, I use invasive garden ants (*Lasius neglectus*) to study how pathogen load and its distribution among nestmates affect the grooming response of the group. Any given group of ants will carry out the same total grooming work, but will direct their grooming effort towards individuals\r\ncarrying a relatively higher spore load. Contrary to expectation, the highest risk of transmission does not stem from grooming highly contaminated ants, but instead, we suggest that the grooming response likely minimizes spore loss to the environment, reducing contamination from inadvertent pickup from the substrate.\r\n\r\nThe second is a comparative developmental approach. I follow black garden ant queens (*Lasius niger*) and their colonies from mating flight, through hibernation for a year. Colonies which grow fast from the start, have a lower chance of survival through hibernation, and those which survive grow at a lower pace later. This is true for colonies of naive\r\nand challenged queens. Early pathogen exposure of the queens changes colony dynamics in an unexpected way: colonies from exposed queens are more likely to grow slowly and recover in numbers only after they survive hibernation.\r\n\r\nIn addition to the two experimental chapters, this thesis includes a co-authored published review on organisational\r\nimmunity, where we enlist the experimental evidence and theoretical framework on which this hypothesis is built,\r\nidentify the caveats and underline how the field is ripe to overcome them. In a final chapter, I describe my part in\r\ntwo collaborative efforts, one to develop an image-based tracker, and the second to develop a classifier for ant\r\nbehaviour."}],"oa_version":"Published Version","alternative_title":["ISTA Thesis"],"month":"05","supervisor":[{"first_name":"Sylvia M","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","last_name":"Cremer","orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia M"}],"date_updated":"2023-09-07T12:57:04Z","ddc":["570","006","578","592"],"file_date_updated":"2021-02-11T11:17:15Z","department":[{"_id":"SyCr"}],"_id":"6435","type":"dissertation","status":"public","keyword":["Social Immunity","Sanitary care","Social Insects","Organisational Immunity","Colony development","Multi-target tracking"],"has_accepted_license":"1","year":"2019","day":"07","page":"183","doi":"10.15479/AT:ISTA:6435","date_published":"2019-05-07T00:00:00Z","date_created":"2019-05-13T08:58:35Z","publisher":"Institute of Science and Technology Austria","oa":1,"citation":{"ista":"Casillas Perez BE. 2019. Collective defenses of garden ants against a fungal pathogen. Institute of Science and Technology Austria.","chicago":"Casillas Perez, Barbara E. “Collective Defenses of Garden Ants against a Fungal Pathogen.” Institute of Science and Technology Austria, 2019. https://doi.org/10.15479/AT:ISTA:6435.","ama":"Casillas Perez BE. Collective defenses of garden ants against a fungal pathogen. 2019. doi:10.15479/AT:ISTA:6435","apa":"Casillas Perez, B. E. (2019). Collective defenses of garden ants against a fungal pathogen. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:6435","short":"B.E. Casillas Perez, Collective Defenses of Garden Ants against a Fungal Pathogen, Institute of Science and Technology Austria, 2019.","ieee":"B. E. Casillas Perez, “Collective defenses of garden ants against a fungal pathogen,” Institute of Science and Technology Austria, 2019.","mla":"Casillas Perez, Barbara E. Collective Defenses of Garden Ants against a Fungal Pathogen. Institute of Science and Technology Austria, 2019, doi:10.15479/AT:ISTA:6435."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","author":[{"full_name":"Casillas Perez, Barbara E","last_name":"Casillas Perez","id":"351ED2AA-F248-11E8-B48F-1D18A9856A87","first_name":"Barbara E"}],"article_processing_charge":"No","title":"Collective defenses of garden ants against a fungal pathogen","project":[{"name":"Epidemics in ant societies on a chip","grant_number":"771402","call_identifier":"H2020","_id":"2649B4DE-B435-11E9-9278-68D0E5697425"}]},{"isi":1,"year":"2018","day":"13","publication":"PNAS","page":"2782 - 2787","doi":"10.1073/pnas.1713501115","date_published":"2018-03-13T00:00:00Z","date_created":"2018-12-11T11:46:20Z","quality_controlled":"1","publisher":"National Academy of Sciences","oa":1,"citation":{"apa":"Konrad, M., Pull, C., Metzler, S., Seif, K., Naderlinger, E., Grasse, A. V., & Cremer, S. (2018). Ants avoid superinfections by performing risk-adjusted sanitary care. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.1713501115","ama":"Konrad M, Pull C, Metzler S, et al. Ants avoid superinfections by performing risk-adjusted sanitary care. PNAS. 2018;115(11):2782-2787. doi:10.1073/pnas.1713501115","short":"M. Konrad, C. Pull, S. Metzler, K. Seif, E. Naderlinger, A.V. Grasse, S. Cremer, PNAS 115 (2018) 2782–2787.","ieee":"M. Konrad et al., “Ants avoid superinfections by performing risk-adjusted sanitary care,” PNAS, vol. 115, no. 11. National Academy of Sciences, pp. 2782–2787, 2018.","mla":"Konrad, Matthias, et al. “Ants Avoid Superinfections by Performing Risk-Adjusted Sanitary Care.” PNAS, vol. 115, no. 11, National Academy of Sciences, 2018, pp. 2782–87, doi:10.1073/pnas.1713501115.","ista":"Konrad M, Pull C, Metzler S, Seif K, Naderlinger E, Grasse AV, Cremer S. 2018. Ants avoid superinfections by performing risk-adjusted sanitary care. PNAS. 115(11), 2782–2787.","chicago":"Konrad, Matthias, Christopher Pull, Sina Metzler, Katharina Seif, Elisabeth Naderlinger, Anna V Grasse, and Sylvia Cremer. “Ants Avoid Superinfections by Performing Risk-Adjusted Sanitary Care.” PNAS. National Academy of Sciences, 2018. https://doi.org/10.1073/pnas.1713501115."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","publist_id":"7416","author":[{"last_name":"Konrad","full_name":"Konrad, Matthias","first_name":"Matthias","id":"46528076-F248-11E8-B48F-1D18A9856A87"},{"id":"3C7F4840-F248-11E8-B48F-1D18A9856A87","first_name":"Christopher","full_name":"Pull, Christopher","orcid":"0000-0003-1122-3982","last_name":"Pull"},{"id":"48204546-F248-11E8-B48F-1D18A9856A87","first_name":"Sina","last_name":"Metzler","orcid":"0000-0002-9547-2494","full_name":"Metzler, Sina"},{"first_name":"Katharina","id":"90F7894A-02CF-11E9-976E-E38CFE5CBC1D","last_name":"Seif","full_name":"Seif, Katharina"},{"full_name":"Naderlinger, Elisabeth","last_name":"Naderlinger","first_name":"Elisabeth","id":"31757262-F248-11E8-B48F-1D18A9856A87"},{"id":"406F989C-F248-11E8-B48F-1D18A9856A87","first_name":"Anna V","last_name":"Grasse","full_name":"Grasse, Anna V"},{"first_name":"Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","last_name":"Cremer","full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868"}],"external_id":{"pmid":["29463746"],"isi":["000427245400069"]},"article_processing_charge":"No","title":"Ants avoid superinfections by performing risk-adjusted sanitary care","project":[{"grant_number":"243071","name":"Social Vaccination in Ant Colonies: from Individual Mechanisms to Society Effects","call_identifier":"FP7","_id":"25DC711C-B435-11E9-9278-68D0E5697425"}],"publication_status":"published","language":[{"iso":"eng"}],"related_material":{"link":[{"url":"https://ist.ac.at/en/news/helping-in-spite-of-risk-ants-perform-risk-averse-sanitary-care-of-infectious-nest-mates/","relation":"press_release","description":"News on IST Homepage"}]},"issue":"11","volume":115,"ec_funded":1,"abstract":[{"text":"Being cared for when sick is a benefit of sociality that can reduce disease and improve survival of group members. However, individuals providing care risk contracting infectious diseases themselves. If they contract a low pathogen dose, they may develop low-level infections that do not cause disease but still affect host immunity by either decreasing or increasing the host’s vulnerability to subsequent infections. Caring for contagious individuals can thus significantly alter the future disease susceptibility of caregivers. Using ants and their fungal pathogens as a model system, we tested if the altered disease susceptibility of experienced caregivers, in turn, affects their expression of sanitary care behavior. We found that low-level infections contracted during sanitary care had protective or neutral effects on secondary exposure to the same (homologous) pathogen but consistently caused high mortality on superinfection with a different (heterologous) pathogen. In response to this risk, the ants selectively adjusted the expression of their sanitary care. Specifically, the ants performed less grooming and more antimicrobial disinfection when caring for nestmates contaminated with heterologous pathogens compared with homologous ones. By modulating the components of sanitary care in this way the ants acquired less infectious particles of the heterologous pathogens, resulting in reduced superinfection. The performance of risk-adjusted sanitary care reveals the remarkable capacity of ants to react to changes in their disease susceptibility, according to their own infection history and to flexibly adjust collective care to individual risk.","lang":"eng"}],"pmid":1,"oa_version":"Published Version","scopus_import":"1","main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pubmed/29463746"}],"month":"03","intvolume":" 115","date_updated":"2023-09-08T13:22:21Z","department":[{"_id":"SyCr"}],"_id":"413","type":"journal_article","status":"public"},{"oa":1,"quality_controlled":"1","publisher":"eLife Sciences Publications","year":"2018","has_accepted_license":"1","isi":1,"publication":"eLife","day":"09","date_created":"2018-12-11T11:47:31Z","date_published":"2018-01-09T00:00:00Z","doi":"10.7554/eLife.32073","article_number":"e32073","project":[{"_id":"25DC711C-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"Social Vaccination in Ant Colonies: from Individual Mechanisms to Society Effects","grant_number":"243071"},{"grant_number":"302004","name":"Pathogen Detectors Collective disease defence and pathogen detection abilities in ant societies: a chemo-neuro-immunological approach","_id":"25DDF0F0-B435-11E9-9278-68D0E5697425","call_identifier":"FP7"}],"citation":{"chicago":"Pull, Christopher, Line V Ugelvig, Florian Wiesenhofer, Anna V Grasse, Simon Tragust, Thomas Schmitt, Mark Brown, and Sylvia Cremer. “Destructive Disinfection of Infected Brood Prevents Systemic Disease Spread in Ant Colonies.” ELife. eLife Sciences Publications, 2018. https://doi.org/10.7554/eLife.32073.","ista":"Pull C, Ugelvig LV, Wiesenhofer F, Grasse AV, Tragust S, Schmitt T, Brown M, Cremer S. 2018. Destructive disinfection of infected brood prevents systemic disease spread in ant colonies. eLife. 7, e32073.","mla":"Pull, Christopher, et al. “Destructive Disinfection of Infected Brood Prevents Systemic Disease Spread in Ant Colonies.” ELife, vol. 7, e32073, eLife Sciences Publications, 2018, doi:10.7554/eLife.32073.","apa":"Pull, C., Ugelvig, L. V., Wiesenhofer, F., Grasse, A. V., Tragust, S., Schmitt, T., … Cremer, S. (2018). Destructive disinfection of infected brood prevents systemic disease spread in ant colonies. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.32073","ama":"Pull C, Ugelvig LV, Wiesenhofer F, et al. Destructive disinfection of infected brood prevents systemic disease spread in ant colonies. eLife. 2018;7. doi:10.7554/eLife.32073","short":"C. Pull, L.V. Ugelvig, F. Wiesenhofer, A.V. Grasse, S. Tragust, T. Schmitt, M. Brown, S. Cremer, ELife 7 (2018).","ieee":"C. Pull et al., “Destructive disinfection of infected brood prevents systemic disease spread in ant colonies,” eLife, vol. 7. eLife Sciences Publications, 2018."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","external_id":{"isi":["000419601300001"]},"article_processing_charge":"Yes","author":[{"last_name":"Pull","orcid":"0000-0003-1122-3982","full_name":"Pull, Christopher","id":"3C7F4840-F248-11E8-B48F-1D18A9856A87","first_name":"Christopher"},{"first_name":"Line V","id":"3DC97C8E-F248-11E8-B48F-1D18A9856A87","last_name":"Ugelvig","full_name":"Ugelvig, Line V","orcid":"0000-0003-1832-8883"},{"id":"39523C54-F248-11E8-B48F-1D18A9856A87","first_name":"Florian","full_name":"Wiesenhofer, Florian","last_name":"Wiesenhofer"},{"last_name":"Grasse","full_name":"Grasse, Anna V","first_name":"Anna V","id":"406F989C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Tragust, Simon","last_name":"Tragust","id":"35A7A418-F248-11E8-B48F-1D18A9856A87","first_name":"Simon"},{"first_name":"Thomas","full_name":"Schmitt, Thomas","last_name":"Schmitt"},{"first_name":"Mark","full_name":"Brown, Mark","last_name":"Brown"},{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia","last_name":"Cremer","orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia"}],"publist_id":"7188","title":"Destructive disinfection of infected brood prevents systemic disease spread in ant colonies","abstract":[{"lang":"eng","text":"Social insects protect their colonies from infectious disease through collective defences that result in social immunity. In ants, workers first try to prevent infection of colony members. Here, we show that if this fails and a pathogen establishes an infection, ants employ an efficient multicomponent behaviour − "destructive disinfection" − to prevent further spread of disease through the colony. Ants specifically target infected pupae during the pathogen's non-contagious incubation period, relying on chemical 'sickness cues' emitted by pupae. They then remove the pupal cocoon, perforate its cuticle and administer antimicrobial poison, which enters the body and prevents pathogen replication from the inside out. Like the immune system of a body that specifically targets and eliminates infected cells, this social immunity measure sacrifices infected brood to stop the pathogen completing its lifecycle, thus protecting the rest of the colony. Hence, the same principles of disease defence apply at different levels of biological organisation."}],"oa_version":"Published Version","scopus_import":"1","intvolume":" 7","month":"01","publication_status":"published","language":[{"iso":"eng"}],"file":[{"checksum":"540f941e8d3530a9441e4affd94f07d7","file_id":"4832","content_type":"application/pdf","access_level":"open_access","relation":"main_file","date_created":"2018-12-12T10:10:43Z","file_name":"IST-2018-978-v1+1_elife-32073-v1.pdf","date_updated":"2020-07-14T12:47:20Z","file_size":1435585,"creator":"system"}],"ec_funded":1,"volume":7,"related_material":{"record":[{"relation":"dissertation_contains","id":"819","status":"public"}]},"_id":"616","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","pubrep_id":"978","status":"public","date_updated":"2023-09-11T12:54:26Z","ddc":["570","590"],"file_date_updated":"2020-07-14T12:47:20Z","department":[{"_id":"SyCr"}]},{"acknowledgement":"We would like to thank Susann Wicke for performing the genome-wide SNP/indel analyses, as well as Veronica Alves, Kevin Ferro, Momir Futo, Barbara Hasert, Dafne Maximo, Nora Schulz, Marlene Sroka, and Barth Wieczorek for technical help. We thank Brian Lazzaro for the L. lactis strain and Bruno Lemaitre for the Pseudomonas entomophila strain. We would like to thank two anonymous reviewers for their helpful comments. We are grateful to the Deutsche Forschungsgemeinschaft (DFG) priority programme 1399 ‘Host parasite coevolution’ for funding this project (AR 872/1-1). ","quality_controlled":"1","publisher":"Wiley","oa":1,"day":"01","publication":"Journal of Evolutionary Biology","isi":1,"year":"2018","date_published":"2018-01-01T00:00:00Z","doi":"10.1111/jeb.13211","date_created":"2018-12-11T11:47:31Z","page":"159 - 171","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"short":"M. Kutzer, J. Kurtz, S. Armitage, Journal of Evolutionary Biology 31 (2018) 159–171.","ieee":"M. Kutzer, J. Kurtz, and S. Armitage, “Genotype and diet affect resistance, survival, and fecundity but not fecundity tolerance,” Journal of Evolutionary Biology, vol. 31, no. 1. Wiley, pp. 159–171, 2018.","ama":"Kutzer M, Kurtz J, Armitage S. Genotype and diet affect resistance, survival, and fecundity but not fecundity tolerance. Journal of Evolutionary Biology. 2018;31(1):159-171. doi:10.1111/jeb.13211","apa":"Kutzer, M., Kurtz, J., & Armitage, S. (2018). Genotype and diet affect resistance, survival, and fecundity but not fecundity tolerance. Journal of Evolutionary Biology. Wiley. https://doi.org/10.1111/jeb.13211","mla":"Kutzer, Megan, et al. “Genotype and Diet Affect Resistance, Survival, and Fecundity but Not Fecundity Tolerance.” Journal of Evolutionary Biology, vol. 31, no. 1, Wiley, 2018, pp. 159–71, doi:10.1111/jeb.13211.","ista":"Kutzer M, Kurtz J, Armitage S. 2018. Genotype and diet affect resistance, survival, and fecundity but not fecundity tolerance. Journal of Evolutionary Biology. 31(1), 159–171.","chicago":"Kutzer, Megan, Joachim Kurtz, and Sophie Armitage. “Genotype and Diet Affect Resistance, Survival, and Fecundity but Not Fecundity Tolerance.” Journal of Evolutionary Biology. Wiley, 2018. https://doi.org/10.1111/jeb.13211."},"title":"Genotype and diet affect resistance, survival, and fecundity but not fecundity tolerance","author":[{"full_name":"Kutzer, Megan","orcid":"0000-0002-8696-6978","last_name":"Kutzer","first_name":"Megan","id":"29D0B332-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Kurtz, Joachim","last_name":"Kurtz","first_name":"Joachim"},{"full_name":"Armitage, Sophie","last_name":"Armitage","first_name":"Sophie"}],"publist_id":"7187","article_processing_charge":"No","external_id":{"isi":["000419307000014"],"pmid":["29150962"]},"oa_version":"Published Version","pmid":1,"abstract":[{"text":"Insects are exposed to a variety of potential pathogens in their environment, many of which can severely impact fitness and health. Consequently, hosts have evolved resistance and tolerance strategies to suppress or cope with infections. Hosts utilizing resistance improve fitness by clearing or reducing pathogen loads, and hosts utilizing tolerance reduce harmful fitness effects per pathogen load. To understand variation in, and selective pressures on, resistance and tolerance, we asked to what degree they are shaped by host genetic background, whether plasticity in these responses depends upon dietary environment, and whether there are interactions between these two factors. Females from ten wild-type Drosophila melanogaster genotypes were kept on high- or low-protein (yeast) diets and infected with one of two opportunistic bacterial pathogens, Lactococcus lactis or Pseudomonas entomophila. We measured host resistance as the inverse of bacterial load in the early infection phase. The relationship (slope) between fly fecundity and individual-level bacteria load provided our fecundity tolerance measure. Genotype and dietary yeast determined host fecundity and strongly affected survival after infection with pathogenic P. entomophila. There was considerable genetic variation in host resistance, a commonly found phenomenon resulting from for example varying resistance costs or frequency-dependent selection. Despite this variation and the reproductive cost of higher P. entomophila loads, fecundity tolerance did not vary across genotypes. The absence of genetic variation in tolerance may suggest that at this early infection stage, fecundity tolerance is fixed or that any evolved tolerance mechanisms are not expressed under these infection conditions.","lang":"eng"}],"month":"01","intvolume":" 31","scopus_import":"1","main_file_link":[{"url":"https://doi.org/10.1111/jeb.13211","open_access":"1"}],"language":[{"iso":"eng"}],"publication_identifier":{"eissn":["1420-9101"],"issn":["1010-061X"]},"publication_status":"published","volume":31,"issue":"1","_id":"617","status":"public","type":"journal_article","article_type":"original","date_updated":"2023-09-11T14:06:04Z","department":[{"_id":"SyCr"}]},{"acknowledgement":"Research with C. obscurior from Brazil was permitted by Instituto Brasileiro do Meio Ambiente e dos Recursos Naturais Renováveis, IBAMA (permit no. 20324-1). We thank the German Science Foundation ( DFG ) for funding ( Schr1135/2-1 ), T. Suckert for help with sperm length measurements and A.K. Huylmans for advice concerning graphs. One referee made helpful comments on the manuscript.\r\n","quality_controlled":"1","publisher":"Elsevier","publication":"Journal of Insect Physiology","day":"01","year":"2018","isi":1,"date_created":"2018-12-11T11:46:25Z","doi":"10.1016/j.jinsphys.2017.12.003","date_published":"2018-05-01T00:00:00Z","page":"284-290","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"mla":"Metzler, Sina, et al. “Individual- and Ejaculate-Specific Sperm Traits in Ant Males.” Journal of Insect Physiology, vol. 107, Elsevier, 2018, pp. 284–90, doi:10.1016/j.jinsphys.2017.12.003.","short":"S. Metzler, A. Schrempf, J. Heinze, Journal of Insect Physiology 107 (2018) 284–290.","ieee":"S. Metzler, A. Schrempf, and J. Heinze, “Individual- and ejaculate-specific sperm traits in ant males,” Journal of Insect Physiology, vol. 107. Elsevier, pp. 284–290, 2018.","apa":"Metzler, S., Schrempf, A., & Heinze, J. (2018). Individual- and ejaculate-specific sperm traits in ant males. Journal of Insect Physiology. Elsevier. https://doi.org/10.1016/j.jinsphys.2017.12.003","ama":"Metzler S, Schrempf A, Heinze J. Individual- and ejaculate-specific sperm traits in ant males. Journal of Insect Physiology. 2018;107:284-290. doi:10.1016/j.jinsphys.2017.12.003","chicago":"Metzler, Sina, Alexandra Schrempf, and Jürgen Heinze. “Individual- and Ejaculate-Specific Sperm Traits in Ant Males.” Journal of Insect Physiology. Elsevier, 2018. https://doi.org/10.1016/j.jinsphys.2017.12.003.","ista":"Metzler S, Schrempf A, Heinze J. 2018. Individual- and ejaculate-specific sperm traits in ant males. Journal of Insect Physiology. 107, 284–290."},"title":"Individual- and ejaculate-specific sperm traits in ant males","external_id":{"isi":["000434751100034"]},"article_processing_charge":"No","publist_id":"7397","author":[{"orcid":"0000-0002-9547-2494","full_name":"Metzler, Sina","last_name":"Metzler","first_name":"Sina","id":"48204546-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Schrempf","full_name":"Schrempf, Alexandra","first_name":"Alexandra"},{"first_name":"Jürgen","full_name":"Heinze, Jürgen","last_name":"Heinze"}],"oa_version":"None","abstract":[{"lang":"eng","text":"Sperm cells are the most morphologically diverse cells across animal taxa. Within species, sperm and ejaculate traits have been suggested to vary with the male's competitive environment, e.g., level of sperm competition, female mating status and quality, and also with male age, body mass, physiological condition, and resource availability. Most previous studies have based their conclusions on the analysis of only one or a few ejaculates per male without investigating differences among the ejaculates of the same individual. This masks potential ejaculate-specific traits. Here, we provide data on the length, quantity, and viability of sperm ejaculated by wingless males of the ant Cardiocondyla obscurior. Males of this ant species are relatively long-lived and can mate with large numbers of female sexuals throughout their lives. We analyzed all ejaculates across the individuals' lifespan and manipulated the availability of mating partners. Our study shows that both the number and size of sperm cells transferred during copulations differ among individuals and also among ejaculates of the same male. Sperm quality does not decrease with male age, but the variation in sperm number between ejaculates indicates that males need considerable time to replenish their sperm supplies. Producing many ejaculates in a short time appears to be traded-off against male longevity rather than sperm quality."}],"intvolume":" 107","month":"05","scopus_import":"1","language":[{"iso":"eng"}],"publication_status":"published","volume":107,"_id":"426","status":"public","type":"journal_article","date_updated":"2023-09-12T07:43:26Z","department":[{"_id":"SyCr"}]},{"publication_identifier":{"issn":["08926638"]},"publication_status":"published","language":[{"iso":"eng"}],"issue":"12","volume":32,"abstract":[{"text":"Ants are emerging model systems to study cellular signaling because distinct castes possess different physiologic phenotypes within the same colony. Here we studied the functionality of inotocin signaling, an insect ortholog of mammalian oxytocin (OT), which was recently discovered in ants. In Lasius ants, we determined that specialization within the colony, seasonal factors, and physiologic conditions down-regulated the expression of the OT-like signaling system. Given this natural variation, we interrogated its function using RNAi knockdowns. Next-generation RNA sequencing of OT-like precursor knock-down ants highlighted its role in the regulation of genes involved in metabolism. Knock-down ants exhibited higher walking activity and increased self-grooming in the brood chamber. We propose that OT-like signaling in ants is important for regulating metabolic processes and locomotion.","lang":"eng"}],"oa_version":"Published Version","pmid":1,"scopus_import":"1","main_file_link":[{"open_access":"1","url":" https://doi.org/10.1096/fj.201800443"}],"month":"11","intvolume":" 32","date_updated":"2023-09-13T09:37:32Z","department":[{"_id":"SyCr"}],"_id":"194","type":"journal_article","article_type":"original","status":"public","isi":1,"year":"2018","day":"29","publication":"The FASEB Journal","page":"6808-6821","doi":"10.1096/fj.201800443","date_published":"2018-11-29T00:00:00Z","date_created":"2018-12-11T11:45:08Z","publisher":"FASEB","quality_controlled":"1","oa":1,"citation":{"ieee":"Z. Liutkeviciute et al., “Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity,” The FASEB Journal, vol. 32, no. 12. FASEB, pp. 6808–6821, 2018.","short":"Z. Liutkeviciute, E. Gil Mansilla, T. Eder, B.E. Casillas Perez, M. Giulia Di Giglio, E. Muratspahić, F. Grebien, T. Rattei, M. Muttenthaler, S. Cremer, C. Gruber, The FASEB Journal 32 (2018) 6808–6821.","ama":"Liutkeviciute Z, Gil Mansilla E, Eder T, et al. Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity. The FASEB Journal. 2018;32(12):6808-6821. doi:10.1096/fj.201800443","apa":"Liutkeviciute, Z., Gil Mansilla, E., Eder, T., Casillas Perez, B. E., Giulia Di Giglio, M., Muratspahić, E., … Gruber, C. (2018). Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity. The FASEB Journal. FASEB. https://doi.org/10.1096/fj.201800443","mla":"Liutkeviciute, Zita, et al. “Oxytocin-like Signaling in Ants Influences Metabolic Gene Expression and Locomotor Activity.” The FASEB Journal, vol. 32, no. 12, FASEB, 2018, pp. 6808–21, doi:10.1096/fj.201800443.","ista":"Liutkeviciute Z, Gil Mansilla E, Eder T, Casillas Perez BE, Giulia Di Giglio M, Muratspahić E, Grebien F, Rattei T, Muttenthaler M, Cremer S, Gruber C. 2018. Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity. The FASEB Journal. 32(12), 6808–6821.","chicago":"Liutkeviciute, Zita, Esther Gil Mansilla, Thomas Eder, Barbara E Casillas Perez, Maria Giulia Di Giglio, Edin Muratspahić, Florian Grebien, et al. “Oxytocin-like Signaling in Ants Influences Metabolic Gene Expression and Locomotor Activity.” The FASEB Journal. FASEB, 2018. https://doi.org/10.1096/fj.201800443."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","author":[{"first_name":"Zita","full_name":"Liutkeviciute, Zita","last_name":"Liutkeviciute"},{"last_name":"Gil Mansilla","full_name":"Gil Mansilla, Esther","first_name":"Esther"},{"last_name":"Eder","full_name":"Eder, Thomas","first_name":"Thomas"},{"id":"351ED2AA-F248-11E8-B48F-1D18A9856A87","first_name":"Barbara E","last_name":"Casillas Perez","full_name":"Casillas Perez, Barbara E"},{"full_name":"Giulia Di Giglio, Maria","last_name":"Giulia Di Giglio","first_name":"Maria"},{"last_name":"Muratspahić","full_name":"Muratspahić, Edin","first_name":"Edin"},{"first_name":"Florian","full_name":"Grebien, Florian","last_name":"Grebien"},{"first_name":"Thomas","last_name":"Rattei","full_name":"Rattei, Thomas"},{"first_name":"Markus","last_name":"Muttenthaler","full_name":"Muttenthaler, Markus"},{"first_name":"Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868","last_name":"Cremer"},{"first_name":"Christian","full_name":"Gruber, Christian","last_name":"Gruber"}],"publist_id":"7721","external_id":{"isi":["000449359700035"],"pmid":["29939785"]},"article_processing_charge":"No","title":"Oxytocin-like signaling in ants influences metabolic gene expression and locomotor activity","project":[{"_id":"25E3D34E-B435-11E9-9278-68D0E5697425","name":"Individual function and social role of oxytocin-like neuropeptides in ants"}]},{"date_updated":"2023-09-15T12:06:46Z","department":[{"_id":"SyCr"}],"_id":"55","status":"public","type":"journal_article","article_type":"original","language":[{"iso":"eng"}],"publication_status":"published","issue":"19","volume":28,"oa_version":"Published Version","abstract":[{"lang":"eng","text":"Many animals use antimicrobials to prevent or cure disease [1,2]. For example, some animals will ingest plants with medicinal properties, both prophylactically to prevent infection and therapeutically to self-medicate when sick. Antimicrobial substances are also used as topical disinfectants, to prevent infection, protect offspring and to sanitise their surroundings [1,2]. Social insects (ants, bees, wasps and termites) build nests in environments with a high abundance and diversity of pathogenic microorganisms — such as soil and rotting wood — and colonies are often densely crowded, creating conditions that favour disease outbreaks. Consequently, social insects have evolved collective disease defences to protect their colonies from epidemics. These traits can be seen as functionally analogous to the immune system of individual organisms [3,4]. This ‘social immunity’ utilises antimicrobials to prevent and eradicate infections, and to keep the brood and nest clean. However, these antimicrobial compounds can be harmful to the insects themselves, and it is unknown how colonies prevent collateral damage when using them. Here, we demonstrate that antimicrobial acids, produced by workers to disinfect the colony, are harmful to the delicate pupal brood stage, but that the pupae are protected from the acids by the presence of a silk cocoon. Garden ants spray their nests with an antimicrobial poison to sanitize contaminated nestmates and brood. Here, Pull et al show that they also prophylactically sanitise their colonies, and that the silk cocoon serves as a barrier to protect developing pupae, thus preventing collateral damage during nest sanitation."}],"intvolume":" 28","month":"10","main_file_link":[{"url":"https://doi.org/10.1016/j.cub.2018.08.063","open_access":"1"}],"scopus_import":"1","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"ista":"Pull C, Metzler S, Naderlinger E, Cremer S. 2018. Protection against the lethal side effects of social immunity in ants. Current Biology. 28(19), R1139–R1140.","chicago":"Pull, Christopher, Sina Metzler, Elisabeth Naderlinger, and Sylvia Cremer. “Protection against the Lethal Side Effects of Social Immunity in Ants.” Current Biology. Cell Press, 2018. https://doi.org/10.1016/j.cub.2018.08.063.","apa":"Pull, C., Metzler, S., Naderlinger, E., & Cremer, S. (2018). Protection against the lethal side effects of social immunity in ants. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2018.08.063","ama":"Pull C, Metzler S, Naderlinger E, Cremer S. Protection against the lethal side effects of social immunity in ants. Current Biology. 2018;28(19):R1139-R1140. doi:10.1016/j.cub.2018.08.063","ieee":"C. Pull, S. Metzler, E. Naderlinger, and S. Cremer, “Protection against the lethal side effects of social immunity in ants,” Current Biology, vol. 28, no. 19. Cell Press, pp. R1139–R1140, 2018.","short":"C. Pull, S. Metzler, E. Naderlinger, S. Cremer, Current Biology 28 (2018) R1139–R1140.","mla":"Pull, Christopher, et al. “Protection against the Lethal Side Effects of Social Immunity in Ants.” Current Biology, vol. 28, no. 19, Cell Press, 2018, pp. R1139–40, doi:10.1016/j.cub.2018.08.063."},"title":"Protection against the lethal side effects of social immunity in ants","article_processing_charge":"No","external_id":{"isi":["000446693400008"]},"author":[{"first_name":"Christopher","id":"3C7F4840-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1122-3982","full_name":"Pull, Christopher","last_name":"Pull"},{"id":"48204546-F248-11E8-B48F-1D18A9856A87","first_name":"Sina","last_name":"Metzler","full_name":"Metzler, Sina","orcid":"0000-0002-9547-2494"},{"full_name":"Naderlinger, Elisabeth","last_name":"Naderlinger","first_name":"Elisabeth","id":"31757262-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868","last_name":"Cremer"}],"publist_id":"7999","publication":"Current Biology","day":"08","year":"2018","isi":1,"date_created":"2018-12-11T11:44:23Z","doi":"10.1016/j.cub.2018.08.063","date_published":"2018-10-08T00:00:00Z","page":"R1139 - R1140","oa":1,"quality_controlled":"1","publisher":"Cell Press"},{"ddc":["576","591"],"date_updated":"2023-09-19T09:29:12Z","department":[{"_id":"SyCr"}],"file_date_updated":"2020-07-14T12:45:52Z","_id":"29","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","language":[{"iso":"eng"}],"file":[{"relation":"main_file","access_level":"open_access","content_type":"application/pdf","file_id":"5682","checksum":"0d1355c78627ca7210aadd9a17a01915","creator":"dernst","file_size":1272096,"date_updated":"2020-07-14T12:45:52Z","file_name":"Viljakainen_et_al-2018-Ecology_and_Evolution.pdf","date_created":"2018-12-17T08:27:04Z"}],"publication_status":"published","publication_identifier":{"issn":["20457758"]},"issue":"22","volume":8,"oa_version":"Published Version","abstract":[{"lang":"eng","text":"Social insects have evolved enormous capacities to collectively build nests and defend their colonies against both predators and pathogens. The latter is achieved by a combination of individual immune responses and sophisticated collective behavioral and organizational disease defenses, that is, social immunity. We investigated how the presence or absence of these social defense lines affects individual-level immunity in ant queens after bacterial infection. To this end, we injected queens of the ant Linepithema humile with a mix of gram+ and gram− bacteria or a control solution, reared them either with workers or alone and analyzed their gene expression patterns at 2, 4, 8, and 12 hr post-injection, using RNA-seq. This allowed us to test for the effect of bacterial infection, social context, as well as the interaction between the two over the course of infection and raising of an immune response. We found that social isolation per se affected queen gene expression for metabolism genes, but not for immune genes. When infected, queens reared with and without workers up-regulated similar numbers of innate immune genes revealing activation of Toll and Imd signaling pathways and melanization. Interestingly, however, they mostly regulated different genes along the pathways and showed a different pattern of overall gene up-regulation or down-regulation. Hence, we can conclude that the absence of workers does not compromise the onset of an individual immune response by the queens, but that the social environment impacts the route of the individual innate immune responses."}],"intvolume":" 8","month":"11","scopus_import":"1","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"mla":"Viljakainen, Lumi, et al. “Social Environment Affects the Transcriptomic Response to Bacteria in Ant Queens.” Ecology and Evolution, vol. 8, no. 22, Wiley, 2018, pp. 11031–70, doi:10.1002/ece3.4573.","ieee":"L. Viljakainen, J. Jurvansuu, I. Holmberg, T. Pamminger, S. Erler, and S. Cremer, “Social environment affects the transcriptomic response to bacteria in ant queens,” Ecology and Evolution, vol. 8, no. 22. Wiley, pp. 11031–11070, 2018.","short":"L. Viljakainen, J. Jurvansuu, I. Holmberg, T. Pamminger, S. Erler, S. Cremer, Ecology and Evolution 8 (2018) 11031–11070.","ama":"Viljakainen L, Jurvansuu J, Holmberg I, Pamminger T, Erler S, Cremer S. Social environment affects the transcriptomic response to bacteria in ant queens. Ecology and Evolution. 2018;8(22):11031-11070. doi:10.1002/ece3.4573","apa":"Viljakainen, L., Jurvansuu, J., Holmberg, I., Pamminger, T., Erler, S., & Cremer, S. (2018). Social environment affects the transcriptomic response to bacteria in ant queens. Ecology and Evolution. Wiley. https://doi.org/10.1002/ece3.4573","chicago":"Viljakainen, Lumi, Jaana Jurvansuu, Ida Holmberg, Tobias Pamminger, Silvio Erler, and Sylvia Cremer. “Social Environment Affects the Transcriptomic Response to Bacteria in Ant Queens.” Ecology and Evolution. Wiley, 2018. https://doi.org/10.1002/ece3.4573.","ista":"Viljakainen L, Jurvansuu J, Holmberg I, Pamminger T, Erler S, Cremer S. 2018. Social environment affects the transcriptomic response to bacteria in ant queens. Ecology and Evolution. 8(22), 11031–11070."},"title":"Social environment affects the transcriptomic response to bacteria in ant queens","external_id":{"isi":["000451611000032"]},"article_processing_charge":"No","publist_id":"8026","author":[{"last_name":"Viljakainen","full_name":"Viljakainen, Lumi","first_name":"Lumi"},{"full_name":"Jurvansuu, Jaana","last_name":"Jurvansuu","first_name":"Jaana"},{"full_name":"Holmberg, Ida","last_name":"Holmberg","first_name":"Ida"},{"first_name":"Tobias","full_name":"Pamminger, Tobias","last_name":"Pamminger"},{"full_name":"Erler, Silvio","last_name":"Erler","first_name":"Silvio"},{"orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia"}],"publication":"Ecology and Evolution","day":"01","year":"2018","isi":1,"has_accepted_license":"1","date_created":"2018-12-11T11:44:15Z","date_published":"2018-11-01T00:00:00Z","doi":"10.1002/ece3.4573","page":"11031-11070","oa":1,"publisher":"Wiley","quality_controlled":"1"},{"citation":{"ama":"Cremer S, Pull C, Fürst M. Social immunity: Emergence and evolution of colony-level disease protection. Annual Review of Entomology. 2018;63:105-123. doi:10.1146/annurev-ento-020117-043110","apa":"Cremer, S., Pull, C., & Fürst, M. (2018). Social immunity: Emergence and evolution of colony-level disease protection. Annual Review of Entomology. Annual Reviews. https://doi.org/10.1146/annurev-ento-020117-043110","short":"S. Cremer, C. Pull, M. Fürst, Annual Review of Entomology 63 (2018) 105–123.","ieee":"S. Cremer, C. Pull, and M. Fürst, “Social immunity: Emergence and evolution of colony-level disease protection,” Annual Review of Entomology, vol. 63. Annual Reviews, pp. 105–123, 2018.","mla":"Cremer, Sylvia, et al. “Social Immunity: Emergence and Evolution of Colony-Level Disease Protection.” Annual Review of Entomology, vol. 63, Annual Reviews, 2018, pp. 105–23, doi:10.1146/annurev-ento-020117-043110.","ista":"Cremer S, Pull C, Fürst M. 2018. Social immunity: Emergence and evolution of colony-level disease protection. Annual Review of Entomology. 63, 105–123.","chicago":"Cremer, Sylvia, Christopher Pull, and Matthias Fürst. “Social Immunity: Emergence and Evolution of Colony-Level Disease Protection.” Annual Review of Entomology. Annual Reviews, 2018. https://doi.org/10.1146/annurev-ento-020117-043110."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","author":[{"first_name":"Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","last_name":"Cremer","full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868"},{"last_name":"Pull","orcid":"0000-0003-1122-3982","full_name":"Pull, Christopher","first_name":"Christopher","id":"3C7F4840-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Matthias","id":"393B1196-F248-11E8-B48F-1D18A9856A87","last_name":"Fürst","orcid":"0000-0002-3712-925X","full_name":"Fürst, Matthias"}],"publist_id":"6844","article_processing_charge":"No","external_id":{"isi":["000424633700008"]},"title":"Social immunity: Emergence and evolution of colony-level disease protection","isi":1,"year":"2018","day":"07","publication":"Annual Review of Entomology","page":"105 - 123","doi":"10.1146/annurev-ento-020117-043110","date_published":"2018-01-07T00:00:00Z","date_created":"2018-12-11T11:48:36Z","publisher":"Annual Reviews","quality_controlled":"1","date_updated":"2023-09-19T09:29:45Z","department":[{"_id":"SyCr"}],"_id":"806","type":"journal_article","status":"public","publication_identifier":{"issn":["1545-4487"]},"publication_status":"published","language":[{"iso":"eng"}],"related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"819"}]},"volume":63,"abstract":[{"lang":"eng","text":"Social insect colonies have evolved many collectively performed adaptations that reduce the impact of infectious disease and that are expected to maximize their fitness. This colony-level protection is termed social immunity, and it enhances the health and survival of the colony. In this review, we address how social immunity emerges from its mechanistic components to produce colony-level disease avoidance, resistance, and tolerance. To understand the evolutionary causes and consequences of social immunity, we highlight the need for studies that evaluate the effects of social immunity on colony fitness. We discuss the role that host life history and ecology have on predicted eco-evolutionary dynamics, which differ among the social insect lineages. Throughout the review, we highlight current gaps in our knowledge and promising avenues for future research, which we hope will bring us closer to an integrated understanding of socio-eco-evo-immunology."}],"oa_version":"None","scopus_import":"1","month":"01","intvolume":" 63"},{"issue":"6417","volume":362,"related_material":{"record":[{"relation":"research_data","status":"public","id":"13055"}],"link":[{"relation":"press_release","url":"https://ist.ac.at/en/news/for-ants-unity-is-strength-and-health/","description":"News on IST Homepage"}]},"ec_funded":1,"language":[{"iso":"eng"}],"publication_identifier":{"issn":["1095-9203"]},"publication_status":"published","month":"11","intvolume":" 362","scopus_import":"1","main_file_link":[{"url":"https://serval.unil.ch/resource/serval:BIB_E9228C205467.P001/REF.pdf","open_access":"1"}],"oa_version":"Published Version","abstract":[{"lang":"eng","text":"Animal social networks are shaped by multiple selection pressures, including the need to ensure efficient communication and functioning while simultaneously limiting disease transmission. Social animals could potentially further reduce epidemic risk by altering their social networks in the presence of pathogens, yet there is currently no evidence for such pathogen-triggered responses. We tested this hypothesis experimentally in the ant Lasius niger using a combination of automated tracking, controlled pathogen exposure, transmission quantification, and temporally explicit simulations. Pathogen exposure induced behavioral changes in both exposed ants and their nestmates, which helped contain the disease by reinforcing key transmission-inhibitory properties of the colony's contact network. This suggests that social network plasticity in response to pathogens is an effective strategy for mitigating the effects of disease in social groups."}],"department":[{"_id":"SyCr"}],"date_updated":"2023-10-17T11:50:05Z","status":"public","article_type":"original","type":"journal_article","_id":"7","date_published":"2018-11-23T00:00:00Z","doi":"10.1126/science.aat4793","date_created":"2018-12-11T11:44:07Z","page":"941 - 945","day":"23","publication":"Science","isi":1,"year":"2018","quality_controlled":"1","publisher":"AAAS","oa":1,"acknowledgement":"This project was funded by two European Research Council Advanced Grants (Social Life, 249375, and resiliANT, 741491) and two Swiss National Science Foundation grants (CR32I3_141063 and 310030_156732) to L.K. and a European Research Council Starting Grant (SocialVaccines, 243071) to S.C.","title":"Social network plasticity decreases disease transmission in a eusocial insect","publist_id":"8049","author":[{"first_name":"Nathalie","last_name":"Stroeymeyt","full_name":"Stroeymeyt, Nathalie"},{"id":"406F989C-F248-11E8-B48F-1D18A9856A87","first_name":"Anna V","full_name":"Grasse, Anna V","last_name":"Grasse"},{"first_name":"Alessandro","last_name":"Crespi","full_name":"Crespi, Alessandro"},{"last_name":"Mersch","full_name":"Mersch, Danielle","first_name":"Danielle"},{"full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia"},{"first_name":"Laurent","full_name":"Keller, Laurent","last_name":"Keller"}],"article_processing_charge":"No","external_id":{"isi":["000451124500041"]},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"chicago":"Stroeymeyt, Nathalie, Anna V Grasse, Alessandro Crespi, Danielle Mersch, Sylvia Cremer, and Laurent Keller. “Social Network Plasticity Decreases Disease Transmission in a Eusocial Insect.” Science. AAAS, 2018. https://doi.org/10.1126/science.aat4793.","ista":"Stroeymeyt N, Grasse AV, Crespi A, Mersch D, Cremer S, Keller L. 2018. Social network plasticity decreases disease transmission in a eusocial insect. Science. 362(6417), 941–945.","mla":"Stroeymeyt, Nathalie, et al. “Social Network Plasticity Decreases Disease Transmission in a Eusocial Insect.” Science, vol. 362, no. 6417, AAAS, 2018, pp. 941–45, doi:10.1126/science.aat4793.","ama":"Stroeymeyt N, Grasse AV, Crespi A, Mersch D, Cremer S, Keller L. Social network plasticity decreases disease transmission in a eusocial insect. Science. 2018;362(6417):941-945. doi:10.1126/science.aat4793","apa":"Stroeymeyt, N., Grasse, A. V., Crespi, A., Mersch, D., Cremer, S., & Keller, L. (2018). Social network plasticity decreases disease transmission in a eusocial insect. Science. AAAS. https://doi.org/10.1126/science.aat4793","ieee":"N. Stroeymeyt, A. V. Grasse, A. Crespi, D. Mersch, S. Cremer, and L. Keller, “Social network plasticity decreases disease transmission in a eusocial insect,” Science, vol. 362, no. 6417. AAAS, pp. 941–945, 2018.","short":"N. Stroeymeyt, A.V. Grasse, A. Crespi, D. Mersch, S. Cremer, L. Keller, Science 362 (2018) 941–945."},"project":[{"_id":"25DC711C-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"243071","name":"Social Vaccination in Ant Colonies: from Individual Mechanisms to Society Effects"}]},{"day":"23","year":"2018","doi":"10.5281/ZENODO.1322669","date_published":"2018-10-23T00:00:00Z","related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"7"}]},"date_created":"2023-05-23T13:24:51Z","oa_version":"Published Version","abstract":[{"lang":"eng","text":"Dataset for manuscript 'Social network plasticity decreases disease transmission in a eusocial insect'\r\nCompared to previous versions: - raw image files added\r\n - correction of URLs within README.txt file\r\n"}],"month":"10","publisher":"Zenodo","oa":1,"main_file_link":[{"url":"https://doi.org/10.5281/zenodo.1480665","open_access":"1"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["570"],"citation":{"mla":"Stroeymeyt, Nathalie, et al. Social Network Plasticity Decreases Disease Transmission in a Eusocial Insect. Zenodo, 2018, doi:10.5281/ZENODO.1322669.","apa":"Stroeymeyt, N., Grasse, A. V., Crespi, A., Mersch, D., Cremer, S., & Keller, L. (2018). Social network plasticity decreases disease transmission in a eusocial insect. Zenodo. https://doi.org/10.5281/ZENODO.1322669","ama":"Stroeymeyt N, Grasse AV, Crespi A, Mersch D, Cremer S, Keller L. Social network plasticity decreases disease transmission in a eusocial insect. 2018. doi:10.5281/ZENODO.1322669","ieee":"N. Stroeymeyt, A. V. Grasse, A. Crespi, D. Mersch, S. Cremer, and L. Keller, “Social network plasticity decreases disease transmission in a eusocial insect.” Zenodo, 2018.","short":"N. Stroeymeyt, A.V. Grasse, A. Crespi, D. Mersch, S. Cremer, L. Keller, (2018).","chicago":"Stroeymeyt, Nathalie, Anna V Grasse, Alessandro Crespi, Danielle Mersch, Sylvia Cremer, and Laurent Keller. “Social Network Plasticity Decreases Disease Transmission in a Eusocial Insect.” Zenodo, 2018. https://doi.org/10.5281/ZENODO.1322669.","ista":"Stroeymeyt N, Grasse AV, Crespi A, Mersch D, Cremer S, Keller L. 2018. Social network plasticity decreases disease transmission in a eusocial insect, Zenodo, 10.5281/ZENODO.1322669."},"date_updated":"2023-10-17T11:50:04Z","department":[{"_id":"SyCr"}],"title":"Social network plasticity decreases disease transmission in a eusocial insect","author":[{"first_name":"Nathalie","full_name":"Stroeymeyt, Nathalie","last_name":"Stroeymeyt"},{"full_name":"Grasse, Anna V","last_name":"Grasse","id":"406F989C-F248-11E8-B48F-1D18A9856A87","first_name":"Anna V"},{"first_name":"Alessandro","last_name":"Crespi","full_name":"Crespi, Alessandro"},{"first_name":"Danielle","full_name":"Mersch, Danielle","last_name":"Mersch"},{"first_name":"Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia","last_name":"Cremer"},{"full_name":"Keller, Laurent","last_name":"Keller","first_name":"Laurent"}],"article_processing_charge":"No","_id":"13055","status":"public","type":"research_data_reference","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"}},{"language":[{"iso":"eng"}],"file":[{"file_id":"5236","access_level":"open_access","relation":"main_file","content_type":"application/pdf","date_created":"2018-12-12T10:16:46Z","file_name":"IST-2017-814-v1+1_s12864-017-3705-7.pdf","creator":"system","date_updated":"2018-12-12T10:16:46Z","file_size":2379672}],"publication_status":"published","publication_identifier":{"issn":["14712164"]},"related_material":{"record":[{"id":"9859","status":"public","relation":"research_data"},{"status":"public","id":"9860","relation":"research_data"}]},"volume":18,"issue":"1","oa_version":"Published Version","abstract":[{"lang":"eng","text":"Background: The phenomenon of immune priming, i.e. enhanced protection following a secondary exposure to a pathogen, has now been demonstrated in a wide range of invertebrate species. Despite accumulating phenotypic evidence, knowledge of its mechanistic underpinnings is currently very limited. Here we used the system of the red flour beetle, Tribolium castaneum and the insect pathogen Bacillus thuringiensis (Bt) to further our molecular understanding of the oral immune priming phenomenon. We addressed how ingestion of bacterial cues (derived from spore supernatants) of an orally pathogenic and non-pathogenic Bt strain affects gene expression upon later challenge exposure, using a whole-transcriptome sequencing approach. Results: Whereas gene expression of individuals primed with the orally non-pathogenic strain showed minor changes to controls, we found that priming with the pathogenic strain induced regulation of a large set of distinct genes, many of which are known immune candidates. Intriguingly, the immune repertoire activated upon priming and subsequent challenge qualitatively differed from the one mounted upon infection with Bt without previous priming. Moreover, a large subset of priming-specific genes showed an inverse regulation compared to their regulation upon challenge only. Conclusions: Our data demonstrate that gene expression upon infection is strongly affected by previous immune priming. We hypothesise that this shift in gene expression indicates activation of a more targeted and efficient response towards a previously encountered pathogen, in anticipation of potential secondary encounter."}],"intvolume":" 18","month":"04","scopus_import":"1","ddc":["570"],"date_updated":"2023-09-22T09:47:44Z","file_date_updated":"2018-12-12T10:16:46Z","department":[{"_id":"SyCr"}],"_id":"1006","pubrep_id":"814","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","publication":"BMC Genomics","day":"26","year":"2017","has_accepted_license":"1","isi":1,"date_created":"2018-12-11T11:49:39Z","doi":"10.1186/s12864-017-3705-7","date_published":"2017-04-26T00:00:00Z","page":"329","oa":1,"quality_controlled":"1","publisher":"BioMed Central","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"ista":"Greenwood J, Milutinovic B, Peuß R, Behrens S, Essar D, Rosenstiel P, Schulenburg H, Kurtz J. 2017. Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae. BMC Genomics. 18(1), 329.","chicago":"Greenwood, Jenny, Barbara Milutinovic, Robert Peuß, Sarah Behrens, Daniela Essar, Philip Rosenstiel, Hinrich Schulenburg, and Joachim Kurtz. “Oral Immune Priming with Bacillus Thuringiensis Induces a Shift in the Gene Expression of Tribolium Castaneum Larvae.” BMC Genomics. BioMed Central, 2017. https://doi.org/10.1186/s12864-017-3705-7.","ieee":"J. Greenwood et al., “Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae,” BMC Genomics, vol. 18, no. 1. BioMed Central, p. 329, 2017.","short":"J. Greenwood, B. Milutinovic, R. Peuß, S. Behrens, D. Essar, P. Rosenstiel, H. Schulenburg, J. Kurtz, BMC Genomics 18 (2017) 329.","apa":"Greenwood, J., Milutinovic, B., Peuß, R., Behrens, S., Essar, D., Rosenstiel, P., … Kurtz, J. (2017). Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae. BMC Genomics. BioMed Central. https://doi.org/10.1186/s12864-017-3705-7","ama":"Greenwood J, Milutinovic B, Peuß R, et al. Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae. BMC Genomics. 2017;18(1):329. doi:10.1186/s12864-017-3705-7","mla":"Greenwood, Jenny, et al. “Oral Immune Priming with Bacillus Thuringiensis Induces a Shift in the Gene Expression of Tribolium Castaneum Larvae.” BMC Genomics, vol. 18, no. 1, BioMed Central, 2017, p. 329, doi:10.1186/s12864-017-3705-7."},"title":"Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae","external_id":{"isi":["000400625200004"]},"article_processing_charge":"No","author":[{"first_name":"Jenny","full_name":"Greenwood, Jenny","last_name":"Greenwood"},{"id":"2CDC32B8-F248-11E8-B48F-1D18A9856A87","first_name":"Barbara","full_name":"Milutinovic, Barbara","orcid":"0000-0002-8214-4758","last_name":"Milutinovic"},{"first_name":"Robert","full_name":"Peuß, Robert","last_name":"Peuß"},{"full_name":"Behrens, Sarah","last_name":"Behrens","first_name":"Sarah"},{"last_name":"Essar","full_name":"Essar, Daniela","first_name":"Daniela"},{"last_name":"Rosenstiel","full_name":"Rosenstiel, Philip","first_name":"Philip"},{"full_name":"Schulenburg, Hinrich","last_name":"Schulenburg","first_name":"Hinrich"},{"first_name":"Joachim","last_name":"Kurtz","full_name":"Kurtz, Joachim"}],"publist_id":"6392"},{"oa_version":"Published Version","abstract":[{"text":"Lists of all differentially expressed genes in the different priming-challenge treatments (compared to the fully naïve control; xlsx file). Relevant columns include the following: sample_1 and sample_2 – treatment groups being compared; Normalised FPKM sample_1 and sample_2 – FPKM of samples being compared; log2(fold_change) – log2(FPKM sample 2/FPKM sample 1), i.e. negative means sample 1 upregulated compared with sample 2, positive means sample 2 upregulated compared with sample 1; cuffdiff test_statistic – test statistic of differential expression test; p_value – p-value of differential expression test; q_value (FDR correction) – adjusted P-value of differential expression test. (XLSX 598 kb)","lang":"eng"}],"month":"04","oa":1,"main_file_link":[{"url":"https://doi.org/10.6084/m9.figshare.c.3756974_d1.v1","open_access":"1"}],"publisher":"Springer Nature","day":"26","year":"2017","date_created":"2021-08-10T07:59:02Z","date_published":"2017-04-26T00:00:00Z","related_material":{"record":[{"id":"1006","status":"public","relation":"used_in_publication"}]},"doi":"10.6084/m9.figshare.c.3756974_d1.v1","_id":"9859","status":"public","type":"research_data_reference","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","citation":{"chicago":"Greenwood, Jenny, Barbara Milutinovic, Robert Peuß, Sarah Behrens, Daniela Essar, Philip Rosenstiel, Hinrich Schulenburg, and Joachim Kurtz. “Additional File 1: Table S1. of Oral Immune Priming with Bacillus Thuringiensis Induces a Shift in the Gene Expression of Tribolium Castaneum Larvae.” Springer Nature, 2017. https://doi.org/10.6084/m9.figshare.c.3756974_d1.v1.","ista":"Greenwood J, Milutinovic B, Peuß R, Behrens S, Essar D, Rosenstiel P, Schulenburg H, Kurtz J. 2017. Additional file 1: Table S1. of Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae, Springer Nature, 10.6084/m9.figshare.c.3756974_d1.v1.","mla":"Greenwood, Jenny, et al. Additional File 1: Table S1. of Oral Immune Priming with Bacillus Thuringiensis Induces a Shift in the Gene Expression of Tribolium Castaneum Larvae. Springer Nature, 2017, doi:10.6084/m9.figshare.c.3756974_d1.v1.","short":"J. Greenwood, B. Milutinovic, R. Peuß, S. Behrens, D. Essar, P. Rosenstiel, H. Schulenburg, J. Kurtz, (2017).","ieee":"J. Greenwood et al., “Additional file 1: Table S1. of Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae.” Springer Nature, 2017.","apa":"Greenwood, J., Milutinovic, B., Peuß, R., Behrens, S., Essar, D., Rosenstiel, P., … Kurtz, J. (2017). Additional file 1: Table S1. of Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae. Springer Nature. https://doi.org/10.6084/m9.figshare.c.3756974_d1.v1","ama":"Greenwood J, Milutinovic B, Peuß R, et al. Additional file 1: Table S1. of Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae. 2017. doi:10.6084/m9.figshare.c.3756974_d1.v1"},"date_updated":"2023-09-22T09:47:44Z","title":"Additional file 1: Table S1. of Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae","department":[{"_id":"SyCr"}],"article_processing_charge":"No","author":[{"first_name":"Jenny","full_name":"Greenwood, Jenny","last_name":"Greenwood"},{"last_name":"Milutinovic","orcid":"0000-0002-8214-4758","full_name":"Milutinovic, Barbara","id":"2CDC32B8-F248-11E8-B48F-1D18A9856A87","first_name":"Barbara"},{"full_name":"Peuß, Robert","last_name":"Peuß","first_name":"Robert"},{"first_name":"Sarah","last_name":"Behrens","full_name":"Behrens, Sarah"},{"last_name":"Essar","full_name":"Essar, Daniela","first_name":"Daniela"},{"first_name":"Philip","full_name":"Rosenstiel, Philip","last_name":"Rosenstiel"},{"full_name":"Schulenburg, Hinrich","last_name":"Schulenburg","first_name":"Hinrich"},{"last_name":"Kurtz","full_name":"Kurtz, Joachim","first_name":"Joachim"}]},{"year":"2017","day":"26","date_created":"2021-08-10T08:07:12Z","date_published":"2017-04-26T00:00:00Z","doi":"10.6084/m9.figshare.c.3756974_d5.v1","related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"1006"}]},"oa_version":"Published Version","oa":1,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.6084/m9.figshare.c.3756974_d5.v1"}],"publisher":"Springer Nature","month":"04","date_updated":"2023-09-22T09:47:44Z","citation":{"ista":"Greenwood J, Milutinovic B, Peuß R, Behrens S, Essar D, Rosenstiel P, Schulenburg H, Kurtz J. 2017. Additional file 5: Table S3. of Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae, Springer Nature, 10.6084/m9.figshare.c.3756974_d5.v1.","chicago":"Greenwood, Jenny, Barbara Milutinovic, Robert Peuß, Sarah Behrens, Daniela Essar, Philip Rosenstiel, Hinrich Schulenburg, and Joachim Kurtz. “Additional File 5: Table S3. of Oral Immune Priming with Bacillus Thuringiensis Induces a Shift in the Gene Expression of Tribolium Castaneum Larvae.” Springer Nature, 2017. https://doi.org/10.6084/m9.figshare.c.3756974_d5.v1.","apa":"Greenwood, J., Milutinovic, B., Peuß, R., Behrens, S., Essar, D., Rosenstiel, P., … Kurtz, J. (2017). Additional file 5: Table S3. of Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae. Springer Nature. https://doi.org/10.6084/m9.figshare.c.3756974_d5.v1","ama":"Greenwood J, Milutinovic B, Peuß R, et al. Additional file 5: Table S3. of Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae. 2017. doi:10.6084/m9.figshare.c.3756974_d5.v1","ieee":"J. Greenwood et al., “Additional file 5: Table S3. of Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae.” Springer Nature, 2017.","short":"J. Greenwood, B. Milutinovic, R. Peuß, S. Behrens, D. Essar, P. Rosenstiel, H. Schulenburg, J. Kurtz, (2017).","mla":"Greenwood, Jenny, et al. Additional File 5: Table S3. of Oral Immune Priming with Bacillus Thuringiensis Induces a Shift in the Gene Expression of Tribolium Castaneum Larvae. Springer Nature, 2017, doi:10.6084/m9.figshare.c.3756974_d5.v1."},"user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","article_processing_charge":"No","author":[{"first_name":"Jenny","full_name":"Greenwood, Jenny","last_name":"Greenwood"},{"full_name":"Milutinovic, Barbara","orcid":"0000-0002-8214-4758","last_name":"Milutinovic","first_name":"Barbara","id":"2CDC32B8-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Peuß","full_name":"Peuß, Robert","first_name":"Robert"},{"last_name":"Behrens","full_name":"Behrens, Sarah","first_name":"Sarah"},{"last_name":"Essar","full_name":"Essar, Daniela","first_name":"Daniela"},{"full_name":"Rosenstiel, Philip","last_name":"Rosenstiel","first_name":"Philip"},{"last_name":"Schulenburg","full_name":"Schulenburg, Hinrich","first_name":"Hinrich"},{"last_name":"Kurtz","full_name":"Kurtz, Joachim","first_name":"Joachim"}],"title":"Additional file 5: Table S3. of Oral immune priming with Bacillus thuringiensis induces a shift in the gene expression of Tribolium castaneum larvae","department":[{"_id":"SyCr"}],"_id":"9860","type":"research_data_reference","status":"public"},{"intvolume":" 4","month":"07","scopus_import":"1","oa_version":"Published Version","abstract":[{"text":"Infections with potentially lethal pathogens may negatively affect an individual’s lifespan and decrease its reproductive value. The terminal investment hypothesis predicts that individuals faced with a reduced survival should invest more into reproduction instead of maintenance and growth. Several studies suggest that individuals are indeed able to estimate their body condition and to increase their reproductive effort with approaching death, while other studies gave ambiguous results. We investigate whether queens of a perennial social insect (ant) are able to boost their reproduction following infection with an obligate killing pathogen. Social insect queens are special with regard to reproduction and aging, as they outlive conspecific non-reproductive workers. Moreover, in the ant Cardiocondyla obscurior, fecundity increases with queen age. However, it remained unclear whether this reflects negative reproductive senescence or terminal investment in response to approaching death. Here, we test whether queens of C. obscurior react to infection with the entomopathogenic fungus Metarhizium brunneum by an increased egg-laying rate. We show that a fungal infection triggers a reinforced investment in reproduction in queens. This adjustment of the reproductive rate by ant queens is consistent with predictions of the terminal investment hypothesis and is reported for the first time in a social insect.","lang":"eng"}],"related_material":{"record":[{"id":"9853","status":"public","relation":"research_data"}]},"volume":4,"issue":"7","language":[{"iso":"eng"}],"file":[{"checksum":"351ae5e7a37e6e7d9295cd41146c4190","file_id":"4684","relation":"main_file","access_level":"open_access","content_type":"application/pdf","file_name":"IST-2017-849-v1+1_2017_Grasse_Cremer_AntQueens.pdf","date_created":"2018-12-12T10:08:24Z","creator":"system","file_size":530412,"date_updated":"2020-07-14T12:48:15Z"}],"publication_status":"published","publication_identifier":{"issn":["20545703"]},"pubrep_id":"849","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","_id":"914","file_date_updated":"2020-07-14T12:48:15Z","department":[{"_id":"SyCr"}],"ddc":["576","592"],"date_updated":"2023-09-26T15:45:47Z","oa":1,"publisher":"Royal Society, The","quality_controlled":"1","acknowledgement":"We thank two anonymous reviewers for helpful suggestions on the manuscript.","date_created":"2018-12-11T11:49:10Z","doi":"10.1098/rsos.170547","date_published":"2017-07-05T00:00:00Z","publication":"Royal Society Open Science","day":"05","year":"2017","isi":1,"has_accepted_license":"1","article_number":"170547","title":"Ant queens increase their reproductive efforts after pathogen infection","external_id":{"isi":["000406670000025"]},"article_processing_charge":"No","publist_id":"6527","author":[{"last_name":"Giehr","full_name":"Giehr, Julia","first_name":"Julia"},{"id":"406F989C-F248-11E8-B48F-1D18A9856A87","first_name":"Anna V","full_name":"Grasse, Anna V","last_name":"Grasse"},{"last_name":"Cremer","full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia"},{"first_name":"Jürgen","full_name":"Heinze, Jürgen","last_name":"Heinze"},{"first_name":"Alexandra","last_name":"Schrempf","full_name":"Schrempf, Alexandra"}],"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"short":"J. Giehr, A.V. Grasse, S. Cremer, J. Heinze, A. Schrempf, Royal Society Open Science 4 (2017).","ieee":"J. Giehr, A. V. Grasse, S. Cremer, J. Heinze, and A. Schrempf, “Ant queens increase their reproductive efforts after pathogen infection,” Royal Society Open Science, vol. 4, no. 7. Royal Society, The, 2017.","apa":"Giehr, J., Grasse, A. V., Cremer, S., Heinze, J., & Schrempf, A. (2017). Ant queens increase their reproductive efforts after pathogen infection. Royal Society Open Science. Royal Society, The. https://doi.org/10.1098/rsos.170547","ama":"Giehr J, Grasse AV, Cremer S, Heinze J, Schrempf A. Ant queens increase their reproductive efforts after pathogen infection. Royal Society Open Science. 2017;4(7). doi:10.1098/rsos.170547","mla":"Giehr, Julia, et al. “Ant Queens Increase Their Reproductive Efforts after Pathogen Infection.” Royal Society Open Science, vol. 4, no. 7, 170547, Royal Society, The, 2017, doi:10.1098/rsos.170547.","ista":"Giehr J, Grasse AV, Cremer S, Heinze J, Schrempf A. 2017. Ant queens increase their reproductive efforts after pathogen infection. Royal Society Open Science. 4(7), 170547.","chicago":"Giehr, Julia, Anna V Grasse, Sylvia Cremer, Jürgen Heinze, and Alexandra Schrempf. “Ant Queens Increase Their Reproductive Efforts after Pathogen Infection.” Royal Society Open Science. Royal Society, The, 2017. https://doi.org/10.1098/rsos.170547."}},{"_id":"9853","type":"research_data_reference","status":"public","citation":{"chicago":"Giehr, Julia, Anna V Grasse, Sylvia Cremer, Jürgen Heinze, and Alexandra Schrempf. “Raw Data from Ant Queens Increase Their Reproductive Efforts after Pathogen Infection.” The Royal Society, 2017. https://doi.org/10.6084/m9.figshare.5117788.v1.","ista":"Giehr J, Grasse AV, Cremer S, Heinze J, Schrempf A. 2017. Raw data from ant queens increase their reproductive efforts after pathogen infection, The Royal Society, 10.6084/m9.figshare.5117788.v1.","mla":"Giehr, Julia, et al. Raw Data from Ant Queens Increase Their Reproductive Efforts after Pathogen Infection. The Royal Society, 2017, doi:10.6084/m9.figshare.5117788.v1.","short":"J. Giehr, A.V. Grasse, S. Cremer, J. Heinze, A. Schrempf, (2017).","ieee":"J. Giehr, A. V. Grasse, S. Cremer, J. Heinze, and A. Schrempf, “Raw data from ant queens increase their reproductive efforts after pathogen infection.” The Royal Society, 2017.","apa":"Giehr, J., Grasse, A. V., Cremer, S., Heinze, J., & Schrempf, A. (2017). Raw data from ant queens increase their reproductive efforts after pathogen infection. The Royal Society. https://doi.org/10.6084/m9.figshare.5117788.v1","ama":"Giehr J, Grasse AV, Cremer S, Heinze J, Schrempf A. Raw data from ant queens increase their reproductive efforts after pathogen infection. 2017. doi:10.6084/m9.figshare.5117788.v1"},"date_updated":"2023-09-26T15:45:47Z","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","author":[{"first_name":"Julia","full_name":"Giehr, Julia","last_name":"Giehr"},{"last_name":"Grasse","full_name":"Grasse, Anna V","id":"406F989C-F248-11E8-B48F-1D18A9856A87","first_name":"Anna V"},{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia","last_name":"Cremer","full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868"},{"first_name":"Jürgen","last_name":"Heinze","full_name":"Heinze, Jürgen"},{"full_name":"Schrempf, Alexandra","last_name":"Schrempf","first_name":"Alexandra"}],"article_processing_charge":"No","title":"Raw data from ant queens increase their reproductive efforts after pathogen infection","department":[{"_id":"SyCr"}],"abstract":[{"text":"Egg laying rates and infection loads of C. obscurior queens","lang":"eng"}],"oa_version":"Published Version","publisher":"The Royal Society","main_file_link":[{"url":"https://doi.org/10.6084/m9.figshare.5117788.v1","open_access":"1"}],"oa":1,"month":"06","year":"2017","day":"19","related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"914"}]},"date_published":"2017-06-19T00:00:00Z","doi":"10.6084/m9.figshare.5117788.v1","date_created":"2021-08-10T06:57:57Z"},{"oa":1,"quality_controlled":"1","publisher":"Cell Press","publication":"Trends in Ecology and Evolution","day":"01","year":"2017","isi":1,"has_accepted_license":"1","date_created":"2018-12-11T11:48:13Z","doi":"10.1016/j.tree.2017.08.004","date_published":"2017-11-01T00:00:00Z","page":"861 - 872","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"mla":"Kennedy, Patrick, et al. “Deconstructing Superorganisms and Societies to Address Big Questions in Biology.” Trends in Ecology and Evolution, vol. 32, no. 11, Cell Press, 2017, pp. 861–72, doi:10.1016/j.tree.2017.08.004.","ieee":"P. Kennedy et al., “Deconstructing superorganisms and societies to address big questions in biology,” Trends in Ecology and Evolution, vol. 32, no. 11. Cell Press, pp. 861–872, 2017.","short":"P. Kennedy, G. Baron, B. Qiu, D. Freitak, H. Helantera, E. Hunt, F. Manfredini, T. O’Shea Wheller, S. Patalano, C. Pull, T. Sasaki, D. Taylor, C. Wyatt, S. Sumner, Trends in Ecology and Evolution 32 (2017) 861–872.","ama":"Kennedy P, Baron G, Qiu B, et al. Deconstructing superorganisms and societies to address big questions in biology. Trends in Ecology and Evolution. 2017;32(11):861-872. doi:10.1016/j.tree.2017.08.004","apa":"Kennedy, P., Baron, G., Qiu, B., Freitak, D., Helantera, H., Hunt, E., … Sumner, S. (2017). Deconstructing superorganisms and societies to address big questions in biology. Trends in Ecology and Evolution. Cell Press. https://doi.org/10.1016/j.tree.2017.08.004","chicago":"Kennedy, Patrick, Gemma Baron, Bitao Qiu, Dalial Freitak, Heikki Helantera, Edmund Hunt, Fabio Manfredini, et al. “Deconstructing Superorganisms and Societies to Address Big Questions in Biology.” Trends in Ecology and Evolution. Cell Press, 2017. https://doi.org/10.1016/j.tree.2017.08.004.","ista":"Kennedy P, Baron G, Qiu B, Freitak D, Helantera H, Hunt E, Manfredini F, O’Shea Wheller T, Patalano S, Pull C, Sasaki T, Taylor D, Wyatt C, Sumner S. 2017. Deconstructing superorganisms and societies to address big questions in biology. Trends in Ecology and Evolution. 32(11), 861–872."},"title":"Deconstructing superorganisms and societies to address big questions in biology","external_id":{"isi":["000413231900011"]},"article_processing_charge":"No","publist_id":"6933","author":[{"first_name":"Patrick","last_name":"Kennedy","full_name":"Kennedy, Patrick"},{"first_name":"Gemma","full_name":"Baron, Gemma","last_name":"Baron"},{"first_name":"Bitao","last_name":"Qiu","full_name":"Qiu, Bitao"},{"full_name":"Freitak, Dalial","last_name":"Freitak","first_name":"Dalial"},{"last_name":"Helantera","full_name":"Helantera, Heikki","first_name":"Heikki"},{"last_name":"Hunt","full_name":"Hunt, Edmund","first_name":"Edmund"},{"first_name":"Fabio","full_name":"Manfredini, Fabio","last_name":"Manfredini"},{"last_name":"O'Shea Wheller","full_name":"O'Shea Wheller, Thomas","first_name":"Thomas"},{"last_name":"Patalano","full_name":"Patalano, Solenn","first_name":"Solenn"},{"last_name":"Pull","orcid":"0000-0003-1122-3982","full_name":"Pull, Christopher","first_name":"Christopher","id":"3C7F4840-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Takao","full_name":"Sasaki, Takao","last_name":"Sasaki"},{"first_name":"Daisy","last_name":"Taylor","full_name":"Taylor, Daisy"},{"first_name":"Christopher","last_name":"Wyatt","full_name":"Wyatt, Christopher"},{"first_name":"Seirian","last_name":"Sumner","full_name":"Sumner, Seirian"}],"oa_version":"Submitted Version","abstract":[{"text":"Social insect societies are long-standing models for understanding social behaviour and evolution. Unlike other advanced biological societies (such as the multicellular body), the component parts of social insect societies can be easily deconstructed and manipulated. Recent methodological and theoretical innovations have exploited this trait to address an expanded range of biological questions. We illustrate the broadening range of biological insight coming from social insect biology with four examples. These new frontiers promote open-minded, interdisciplinary exploration of one of the richest and most complex of biological phenomena: sociality.","lang":"eng"}],"intvolume":" 32","month":"11","scopus_import":"1","language":[{"iso":"eng"}],"file":[{"date_updated":"2020-07-14T12:47:56Z","file_size":15018382,"creator":"dernst","date_created":"2020-05-14T16:22:27Z","file_name":"2017_TrendsEcology_Kennedy.pdf","content_type":"application/pdf","access_level":"open_access","relation":"main_file","file_id":"7842","checksum":"c8f49309ed9436201814fa7153d66a99"}],"publication_status":"published","publication_identifier":{"issn":["01695347"]},"volume":32,"issue":"11","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"819"}]},"_id":"734","status":"public","article_type":"original","type":"journal_article","ddc":["570"],"date_updated":"2023-09-27T14:15:15Z","file_date_updated":"2020-07-14T12:47:56Z","department":[{"_id":"SyCr"}]},{"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","citation":{"ieee":"C. Pull, “Disease defence in garden ants,” Institute of Science and Technology Austria, 2017.","short":"C. Pull, Disease Defence in Garden Ants, Institute of Science and Technology Austria, 2017.","ama":"Pull C. Disease defence in garden ants. 2017. doi:10.15479/AT:ISTA:th_861","apa":"Pull, C. (2017). Disease defence in garden ants. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:th_861","mla":"Pull, Christopher. Disease Defence in Garden Ants. Institute of Science and Technology Austria, 2017, doi:10.15479/AT:ISTA:th_861.","ista":"Pull C. 2017. Disease defence in garden ants. Institute of Science and Technology Austria.","chicago":"Pull, Christopher. “Disease Defence in Garden Ants.” Institute of Science and Technology Austria, 2017. https://doi.org/10.15479/AT:ISTA:th_861."},"title":"Disease defence in garden ants","article_processing_charge":"No","author":[{"first_name":"Christopher","id":"3C7F4840-F248-11E8-B48F-1D18A9856A87","full_name":"Pull, Christopher","orcid":"0000-0003-1122-3982","last_name":"Pull"}],"publist_id":"6830","day":"26","year":"2017","has_accepted_license":"1","date_created":"2018-12-11T11:48:40Z","date_published":"2017-09-26T00:00:00Z","doi":"10.15479/AT:ISTA:th_861","page":"122","acknowledgement":"ERC FP7 programme (grant agreement no. 240371)\r\nI have been supremely spoilt to work in a lab with such good resources and I must thank the wonderful Cremer group technicians, Anna, Barbara, Eva and Florian, for all of their help and keeping the lab up and running. You guys will probably be the most missed once I realise just how much work you have been saving me! For the same reason, I must say a big Dzi ę kuj ę Ci to Wonder Woman Wanda, for her tireless efforts feeding my colonies and cranking out thousands of petri dishes and sugar tubes. Again, you will be sorely missed now that I will have to take this task on myself. Of course, I will be eternally indebted to Prof. Sylvia Cremer for taking me under her wing and being a constant source of guidance and inspiration. You have given me the perfect balance of independence and supervision. I cannot thank you enough for creating such a great working environment and allowing me the freedom to follow my own research questions. I have had so many exceptional opportunities – attending and presenting at conferences all over the world, inviting me to write the ARE with you, going to workshops in Panama and Switzerland, and even organising our own PhD course – that I often think I must have had the best PhD in the world. You have taught me so much and made me a scientist. I sincerely hope we get the chance to work together again in the future. Thank you for everything. I must also thank my PhD Committee, Daria Siekhaus and Jacobus “Koos” Boomsma, for being very supportive throughout the duration of my PhD. ","oa":1,"publisher":"Institute of Science and Technology Austria","ddc":["576","577","578","579","590","592"],"date_updated":"2023-09-28T11:31:32Z","supervisor":[{"id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia M","last_name":"Cremer","orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia M"}],"department":[{"_id":"SyCr"}],"file_date_updated":"2020-07-14T12:48:09Z","_id":"819","pubrep_id":"861","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"dissertation","language":[{"iso":"eng"}],"file":[{"relation":"source_file","access_level":"closed","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","checksum":"4993cdd5382295758ecc3ecbd2a9aaff","file_id":"6199","creator":"dernst","file_size":18580400,"date_updated":"2020-07-14T12:48:09Z","file_name":"2017_Thesis_Pull.docx","date_created":"2019-04-05T07:53:04Z"},{"access_level":"open_access","relation":"main_file","content_type":"application/pdf","checksum":"ee2e3ebb5b53c154c866f5b052b25153","file_id":"6200","creator":"dernst","date_updated":"2020-07-14T12:48:09Z","file_size":14400681,"date_created":"2019-04-05T07:53:04Z","file_name":"2017_Thesis_Pull.pdf"}],"publication_status":"published","degree_awarded":"PhD","publication_identifier":{"issn":["2663-337X"]},"related_material":{"record":[{"id":"616","status":"public","relation":"part_of_dissertation"},{"id":"806","status":"public","relation":"part_of_dissertation"},{"relation":"part_of_dissertation","id":"734","status":"public"},{"status":"public","id":"732","relation":"part_of_dissertation"}]},"oa_version":"Published Version","abstract":[{"text":"Contagious diseases must transmit from infectious to susceptible hosts in order to reproduce. Whilst vectored pathogens can rely on intermediaries to find new hosts for them, many infectious pathogens require close contact or direct interaction between hosts for transmission. Hence, this means that conspecifics are often the main source of infection for most animals and so, in theory, animals should avoid conspecifics to reduce their risk of infection. Of course, in reality animals must interact with one another, as a bare minimum, to mate. However, being social provides many additional benefits and group living has become a taxonomically diverse and widespread trait. How then do social animals overcome the issue of increased disease? Over the last few decades, the social insects (ants, termites and some bees and wasps) have become a model system for studying disease in social animals. On paper, a social insect colony should be particularly susceptible to disease, given that they often contain thousands of potential hosts that are closely related and frequently interact, as well as exhibiting stable environmental conditions that encourage microbial growth. Yet, disease outbreaks appear to be rare and attempts to eradicate pest species using pathogens have failed time and again. Evolutionary biologists investigating this observation have discovered that the reduced disease susceptibility in social insects is, in part, due to collectively performed disease defences of the workers. These defences act like a “social immune system” for the colony, resulting in a per capita decrease in disease, termed social immunity. Our understanding of social immunity, and its importance in relation to the immunological defences of each insect, continues to grow, but there remain many open questions. In this thesis I have studied disease defence in garden ants. In the first data chapter, I use the invasive garden ant, Lasius neglectus, to investigate how colonies mitigate lethal infections and prevent them from spreading systemically. I find that ants have evolved ‘destructive disinfection’ – a behaviour that uses endogenously produced acidic poison to kill diseased brood and to prevent the pathogen from replicating. In the second experimental chapter, I continue to study the use of poison in invasive garden ant colonies, finding that it is sprayed prophylactically within the nest. However, this spraying has negative effects on developing pupae when they have had their cocoons artificially removed. Hence, I suggest that acidic nest sanitation may be maintaining larval cocoon spinning in this species. In the next experimental chapter, I investigated how colony founding black garden ant queens (Lasius niger) prevent disease when a co-foundress dies. I show that ant queens prophylactically perform undertaking behaviours, similar to those performed by the workers in mature nests. When a co-foundress was infected, these undertaking behaviours improved the survival of the healthy queen. In the final data chapter, I explored how immunocompetence (measured as antifungal activity) changes as incipient black garden ant colonies grow and mature, from the solitary queen phase to colonies with several hundred workers. Queen and worker antifungal activity varied throughout this time period, but despite social immunity, did not decrease as colonies matured. In addition to the above data chapters, this thesis includes two co-authored reviews. In the first, we examine the state of the art in the field of social immunity and how it might develop in the future. In the second, we identify several challenges and open questions in the study of disease defence in animals. We highlight how social insects offer a unique model to tackle some of these problems, as disease defence can be studied from the cell to the society. ","lang":"eng"}],"month":"09","alternative_title":["ISTA Thesis"]},{"scopus_import":"1","month":"10","intvolume":" 17","abstract":[{"text":"Background: Social insects form densely crowded societies in environments with high pathogen loads, but have evolved collective defences that mitigate the impact of disease. However, colony-founding queens lack this protection and suffer high rates of mortality. The impact of pathogens may be exacerbated in species where queens found colonies together, as healthy individuals may contract pathogens from infectious co-founders. Therefore, we tested whether ant queens avoid founding colonies with pathogen-exposed conspecifics and how they might limit disease transmission from infectious individuals. Results: Using Lasius Niger queens and a naturally infecting fungal pathogen Metarhizium brunneum, we observed that queens were equally likely to found colonies with another pathogen-exposed or sham-treated queen. However, when one queen died, the surviving individual performed biting, burial and removal of the corpse. These undertaking behaviours were performed prophylactically, i.e. targeted equally towards non-infected and infected corpses, as well as carried out before infected corpses became infectious. Biting and burial reduced the risk of the queens contracting and dying from disease from an infectious corpse of a dead co-foundress. Conclusions: We show that co-founding ant queens express undertaking behaviours that, in mature colonies, are performed exclusively by workers. Such infection avoidance behaviours act before the queens can contract the disease and will therefore improve the overall chance of colony founding success in ant queens.","lang":"eng"}],"oa_version":"Published Version","issue":"1","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"819"}]},"volume":17,"ec_funded":1,"publication_identifier":{"issn":["14712148"]},"publication_status":"published","file":[{"date_created":"2018-12-12T10:17:18Z","file_name":"IST-2017-882-v1+1_12862_2017_Article_1062.pdf","creator":"system","date_updated":"2020-07-14T12:47:55Z","file_size":949857,"file_id":"5271","checksum":"3e24a2cfd48f49f7b3643d08d30fb480","access_level":"open_access","relation":"main_file","content_type":"application/pdf"}],"language":[{"iso":"eng"}],"type":"journal_article","article_type":"original","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"status":"public","pubrep_id":"882","_id":"732","file_date_updated":"2020-07-14T12:47:55Z","department":[{"_id":"SyCr"}],"date_updated":"2023-09-28T11:31:32Z","ddc":["576","592"],"quality_controlled":"1","publisher":"BioMed Central","oa":1,"date_published":"2017-10-13T00:00:00Z","doi":"10.1186/s12862-017-1062-4","date_created":"2018-12-11T11:48:12Z","isi":1,"has_accepted_license":"1","year":"2017","day":"13","publication":"BMC Evolutionary Biology","project":[{"call_identifier":"FP7","_id":"25DC711C-B435-11E9-9278-68D0E5697425","grant_number":"243071","name":"Social Vaccination in Ant Colonies: from Individual Mechanisms to Society Effects"}],"article_number":"219","publist_id":"6937","author":[{"last_name":"Pull","full_name":"Pull, Christopher","orcid":"0000-0003-1122-3982","id":"3C7F4840-F248-11E8-B48F-1D18A9856A87","first_name":"Christopher"},{"orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia","last_name":"Cremer","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia"}],"external_id":{"isi":["000412816800001"]},"article_processing_charge":"Yes","title":"Co-founding ant queens prevent disease by performing prophylactic undertaking behaviour","citation":{"short":"C. Pull, S. Cremer, BMC Evolutionary Biology 17 (2017).","ieee":"C. Pull and S. Cremer, “Co-founding ant queens prevent disease by performing prophylactic undertaking behaviour,” BMC Evolutionary Biology, vol. 17, no. 1. BioMed Central, 2017.","apa":"Pull, C., & Cremer, S. (2017). Co-founding ant queens prevent disease by performing prophylactic undertaking behaviour. BMC Evolutionary Biology. BioMed Central. https://doi.org/10.1186/s12862-017-1062-4","ama":"Pull C, Cremer S. Co-founding ant queens prevent disease by performing prophylactic undertaking behaviour. BMC Evolutionary Biology. 2017;17(1). doi:10.1186/s12862-017-1062-4","mla":"Pull, Christopher, and Sylvia Cremer. “Co-Founding Ant Queens Prevent Disease by Performing Prophylactic Undertaking Behaviour.” BMC Evolutionary Biology, vol. 17, no. 1, 219, BioMed Central, 2017, doi:10.1186/s12862-017-1062-4.","ista":"Pull C, Cremer S. 2017. Co-founding ant queens prevent disease by performing prophylactic undertaking behaviour. BMC Evolutionary Biology. 17(1), 219.","chicago":"Pull, Christopher, and Sylvia Cremer. “Co-Founding Ant Queens Prevent Disease by Performing Prophylactic Undertaking Behaviour.” BMC Evolutionary Biology. BioMed Central, 2017. https://doi.org/10.1186/s12862-017-1062-4."},"user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1"},{"file_date_updated":"2020-07-14T12:46:32Z","department":[{"_id":"SyCr"}],"date_updated":"2023-10-17T12:28:13Z","ddc":["592"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by-nd/4.0/legalcode","image":"/image/cc_by_nd.png","name":"Creative Commons Attribution-NoDerivatives 4.0 International (CC BY-ND 4.0)","short":"CC BY-ND (4.0)"},"type":"journal_article","pubrep_id":"962","status":"public","_id":"459","license":"https://creativecommons.org/licenses/by-nd/4.0/","volume":46,"publication_status":"published","publication_identifier":{"issn":["2366-2875"]},"language":[{"iso":"eng"}],"file":[{"date_updated":"2020-07-14T12:46:32Z","file_size":1711131,"creator":"system","date_created":"2018-12-12T10:15:52Z","file_name":"IST-2018-962-v1+1_044676698_07_Cremer__Invasive_Ameisen_in_Europa_...__BY-ND_.pdf","content_type":"application/pdf","access_level":"open_access","relation":"main_file","file_id":"5175","checksum":"4919baf9050415ca151fe22497379f78"}],"intvolume":" 46","month":"04","abstract":[{"text":"The social insects bees, wasps, ants, and termites are species-rich, occur in many habitats, and often constitute a large part of the biomass. Many are also invasive, including species of termites, the red imported fire ant, and the Argentine ant. While invasive social insects have been a problem in Southern Europe for some time, Central Europa was free of invasive ant species until recently because most ants are adapted to warmer climates. Only in the 1990s, did Lasius neglectus, a close relative of the common black garden ant, arrive in Germany. First described in 1990 based on individuals collected in Budapest, the species has since been detected for example in France, Germany, Spain, England, and Kyrgyzstan. The species is spread with soil during construction work or plantings, and L. neglectus therefore is often found in parks and botanical gardens. Another invasive ant now spreading in southern Germany is Formica fuscocinerea, which occurs along rivers, including in the sandy floodplains of the river Isar. As is typical of pioneer species, F. fuscocinerea quickly becomes extremely abundant and therefore causes problems for example on playgrounds in Munich. All invasive ant species are characterized by cooperation across nests, leading to strongly interconnected, very large super-colonies. The resulting dominance results in the extinction of native ant species as well as other arthropod species and thus in the reduction of biodiversity.","lang":"eng"}],"oa_version":"Published Version","article_processing_charge":"No","author":[{"last_name":"Cremer","orcid":"0000-0002-2193-3868","full_name":"Cremer, Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia"}],"publist_id":"7362","title":"Invasive Ameisen in Europa: Wie sie sich ausbreiten und die heimische Fauna verändern","citation":{"mla":"Cremer, Sylvia. “Invasive Ameisen in Europa: Wie Sie Sich Ausbreiten Und Die Heimische Fauna Verändern.” Rundgespräche Forum Ökologie, vol. 46, Verlag Dr. Friedrich Pfeil, 2017, pp. 105–16.","ama":"Cremer S. Invasive Ameisen in Europa: Wie sie sich ausbreiten und die heimische Fauna verändern. Rundgespräche Forum Ökologie. 2017;46:105-116.","apa":"Cremer, S. (2017). Invasive Ameisen in Europa: Wie sie sich ausbreiten und die heimische Fauna verändern. Rundgespräche Forum Ökologie. Verlag Dr. Friedrich Pfeil.","short":"S. Cremer, Rundgespräche Forum Ökologie 46 (2017) 105–116.","ieee":"S. Cremer, “Invasive Ameisen in Europa: Wie sie sich ausbreiten und die heimische Fauna verändern,” Rundgespräche Forum Ökologie, vol. 46. Verlag Dr. Friedrich Pfeil, pp. 105–116, 2017.","chicago":"Cremer, Sylvia. “Invasive Ameisen in Europa: Wie Sie Sich Ausbreiten Und Die Heimische Fauna Verändern.” Rundgespräche Forum Ökologie. Verlag Dr. Friedrich Pfeil, 2017.","ista":"Cremer S. 2017. Invasive Ameisen in Europa: Wie sie sich ausbreiten und die heimische Fauna verändern. Rundgespräche Forum Ökologie. 46, 105–116."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"105 - 116","date_created":"2018-12-11T11:46:35Z","date_published":"2017-04-04T00:00:00Z","year":"2017","has_accepted_license":"1","publication":"Rundgespräche Forum Ökologie","day":"04","oa":1,"quality_controlled":"1","publisher":"Verlag Dr. Friedrich Pfeil"},{"article_number":"0632","title":"Specificity of oral immune priming in the red flour beetle Tribolium castaneum","external_id":{"pmid":["29237813"]},"article_processing_charge":"No","author":[{"first_name":"Momir","full_name":"Futo, Momir","last_name":"Futo"},{"full_name":"Sell, Marie","last_name":"Sell","first_name":"Marie"},{"full_name":"Kutzer, Megan","orcid":"0000-0002-8696-6978","last_name":"Kutzer","id":"29D0B332-F248-11E8-B48F-1D18A9856A87","first_name":"Megan"},{"full_name":"Kurtz, Joachim","last_name":"Kurtz","first_name":"Joachim"}],"publist_id":"7255","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ama":"Futo M, Sell M, Kutzer M, Kurtz J. Specificity of oral immune priming in the red flour beetle Tribolium castaneum. Biology Letters. 2017;13(12). doi:10.1098/rsbl.2017.0632","apa":"Futo, M., Sell, M., Kutzer, M., & Kurtz, J. (2017). Specificity of oral immune priming in the red flour beetle Tribolium castaneum. Biology Letters. The Royal Society. https://doi.org/10.1098/rsbl.2017.0632","ieee":"M. Futo, M. Sell, M. Kutzer, and J. Kurtz, “Specificity of oral immune priming in the red flour beetle Tribolium castaneum,” Biology Letters, vol. 13, no. 12. The Royal Society, 2017.","short":"M. Futo, M. Sell, M. Kutzer, J. Kurtz, Biology Letters 13 (2017).","mla":"Futo, Momir, et al. “Specificity of Oral Immune Priming in the Red Flour Beetle Tribolium Castaneum.” Biology Letters, vol. 13, no. 12, 0632, The Royal Society, 2017, doi:10.1098/rsbl.2017.0632.","ista":"Futo M, Sell M, Kutzer M, Kurtz J. 2017. Specificity of oral immune priming in the red flour beetle Tribolium castaneum. Biology Letters. 13(12), 0632.","chicago":"Futo, Momir, Marie Sell, Megan Kutzer, and Joachim Kurtz. “Specificity of Oral Immune Priming in the Red Flour Beetle Tribolium Castaneum.” Biology Letters. The Royal Society, 2017. https://doi.org/10.1098/rsbl.2017.0632."},"publisher":"The Royal Society","quality_controlled":"1","date_created":"2018-12-11T11:47:10Z","date_published":"2017-12-01T00:00:00Z","doi":"10.1098/rsbl.2017.0632","publication":"Biology Letters","day":"01","year":"2017","status":"public","type":"journal_article","article_type":"original","_id":"558","department":[{"_id":"SyCr"}],"date_updated":"2023-10-18T06:42:25Z","intvolume":" 13","month":"12","scopus_import":"1","pmid":1,"oa_version":"None","abstract":[{"text":"Immune specificity is the degree to which a host’s immune system discriminates among various pathogens or antigenic variants. Vertebrate immune memory is highly specific due to antibody responses. On the other hand, some invertebrates show immune priming, i.e. improved survival after secondary exposure to a previously encountered pathogen. Until now, specificity of priming has only been demonstrated via the septic infection route or when live pathogens were used for priming. Therefore, we tested for specificity in the oral priming route in the red flour beetle, Tribolium castaneum. For priming, we used pathogen-free supernatants derived from three different strains of the entomopathogen, Bacillus thuringiensis, which express different Cry toxin variants known for their toxicity against this beetle. Subsequent exposure to the infective spores showed that oral priming was specific for two naturally occurring strains, while a third engineered strain did not induce any priming effect. Our data demonstrate that oral immune priming with a non-infectious bacterial agent can be specific, but the priming effect is not universal across all bacterial strains.","lang":"eng"}],"issue":"12","volume":13,"language":[{"iso":"eng"}],"publication_status":"published","publication_identifier":{"issn":["1744-9561"]}},{"title":"Mating and longevity in ant males","author":[{"id":"48204546-F248-11E8-B48F-1D18A9856A87","first_name":"Sina","last_name":"Metzler","full_name":"Metzler, Sina"},{"full_name":"Heinze, Jürgen","last_name":"Heinze","first_name":"Jürgen"},{"last_name":"Schrempf","full_name":"Schrempf, Alexandra","first_name":"Alexandra"}],"publist_id":"6169","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","citation":{"chicago":"Metzler, Sina, Jürgen Heinze, and Alexandra Schrempf. “Mating and Longevity in Ant Males.” Ecology and Evolution. Wiley-Blackwell, 2016. https://doi.org/10.1002/ece3.2474.","ista":"Metzler S, Heinze J, Schrempf A. 2016. Mating and longevity in ant males. Ecology and Evolution. 6(24), 8903–8906.","mla":"Metzler, Sina, et al. “Mating and Longevity in Ant Males.” Ecology and Evolution, vol. 6, no. 24, Wiley-Blackwell, 2016, pp. 8903–06, doi:10.1002/ece3.2474.","apa":"Metzler, S., Heinze, J., & Schrempf, A. (2016). Mating and longevity in ant males. Ecology and Evolution. Wiley-Blackwell. https://doi.org/10.1002/ece3.2474","ama":"Metzler S, Heinze J, Schrempf A. Mating and longevity in ant males. Ecology and Evolution. 2016;6(24):8903-8906. doi:10.1002/ece3.2474","ieee":"S. Metzler, J. Heinze, and A. Schrempf, “Mating and longevity in ant males,” Ecology and Evolution, vol. 6, no. 24. Wiley-Blackwell, pp. 8903–8906, 2016.","short":"S. Metzler, J. Heinze, A. Schrempf, Ecology and Evolution 6 (2016) 8903–8906."},"date_created":"2018-12-11T11:50:36Z","doi":"10.1002/ece3.2474","date_published":"2016-12-01T00:00:00Z","page":"8903 - 8906","publication":"Ecology and Evolution","day":"01","year":"2016","has_accepted_license":"1","oa":1,"quality_controlled":"1","publisher":"Wiley-Blackwell","acknowledgement":"German Science Foundation. Grant Number: SCHR 1135/2-1. We thank M. Adam for handling part of the setups and J. Zoellner for behavioral observations.","file_date_updated":"2020-07-14T12:44:37Z","department":[{"_id":"SyCr"}],"ddc":["576","592"],"date_updated":"2021-01-12T06:48:55Z","pubrep_id":"736","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","_id":"1184","issue":"24","volume":6,"language":[{"iso":"eng"}],"file":[{"content_type":"application/pdf","relation":"main_file","access_level":"open_access","checksum":"789026eb9e1be2a0da08376f29f569cf","file_id":"5062","file_size":328414,"date_updated":"2020-07-14T12:44:37Z","creator":"system","file_name":"IST-2017-736-v1+1_Metzler_et_al-2016-Ecology_and_Evolution.pdf","date_created":"2018-12-12T10:14:12Z"}],"publication_status":"published","intvolume":" 6","month":"12","scopus_import":1,"oa_version":"Published Version","abstract":[{"text":"Across multicellular organisms, the costs of reproduction and self-maintenance result in a life history trade-off between fecundity and longevity. Queens of perennial social Hymenoptera are both highly fertile and long-lived, and thus, this fundamental trade-off is lacking. Whether social insect males similarly evade the fecundity/longevity trade-off remains largely unstudied. Wingless males of the ant genus Cardiocondyla stay in their natal colonies throughout their relatively long lives and mate with multiple female sexuals. Here, we show that Cardiocondyla obscurior males that were allowed to mate with large numbers of female sexuals had a shortened life span compared to males that mated at a low frequency or virgin males. Although frequent mating negatively affects longevity, males clearly benefit from a “live fast, die young strategy” by inseminating as many female sexuals as possible at a cost to their own survival.","lang":"eng"}]},{"license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","issue":"4","volume":119,"language":[{"iso":"eng"}],"file":[{"file_name":"2016_Elsevier_Milutinovic.pdf","date_created":"2019-01-25T13:00:20Z","file_size":1473211,"date_updated":"2020-07-14T12:44:39Z","creator":"kschuh","file_id":"5885","checksum":"8396d5bd95f9c4295857162f902afabf","content_type":"application/pdf","relation":"main_file","access_level":"open_access"}],"publication_status":"published","intvolume":" 119","month":"08","scopus_import":1,"oa_version":"Published Version","department":[{"_id":"SyCr"}],"file_date_updated":"2020-07-14T12:44:39Z","ddc":["570"],"date_updated":"2021-01-12T06:49:03Z","status":"public","tmp":{"short":"CC BY-NC-ND (4.0)","name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","image":"/images/cc_by_nc_nd.png"},"type":"journal_article","_id":"1202","date_created":"2018-12-11T11:50:41Z","date_published":"2016-08-01T00:00:00Z","doi":"10.1016/j.zool.2016.03.006","page":"254 - 261","publication":"Zoology ","day":"01","year":"2016","has_accepted_license":"1","oa":1,"quality_controlled":"1","publisher":"Elsevier","acknowledgement":"The authors thank Sophie A.O. Armitage and Jan N. Offenborn for helpful comments on the figures, and two anonymous reviewers for their helpful comments. The project was funded by the Deutsche Forschungsgemeinschaft (DFG, KU 1929/4-2) within the priority programme SPP 1399 “Host–Parasite Coevolution”.","title":"Immune priming in arthropods: an update focusing on the red flour beetle","publist_id":"6147","author":[{"first_name":"Barbara","id":"2CDC32B8-F248-11E8-B48F-1D18A9856A87","last_name":"Milutinovic","full_name":"Milutinovic, Barbara","orcid":"0000-0002-8214-4758"},{"last_name":"Peuß","full_name":"Peuß, Robert","first_name":"Robert"},{"full_name":"Ferro, Kevin","last_name":"Ferro","first_name":"Kevin"},{"first_name":"Joachim","last_name":"Kurtz","full_name":"Kurtz, Joachim"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","citation":{"short":"B. Milutinovic, R. Peuß, K. Ferro, J. Kurtz, Zoology 119 (2016) 254–261.","ieee":"B. Milutinovic, R. Peuß, K. Ferro, and J. Kurtz, “Immune priming in arthropods: an update focusing on the red flour beetle,” Zoology , vol. 119, no. 4. Elsevier, pp. 254–261, 2016.","ama":"Milutinovic B, Peuß R, Ferro K, Kurtz J. Immune priming in arthropods: an update focusing on the red flour beetle. Zoology . 2016;119(4):254-261. doi:10.1016/j.zool.2016.03.006","apa":"Milutinovic, B., Peuß, R., Ferro, K., & Kurtz, J. (2016). Immune priming in arthropods: an update focusing on the red flour beetle. Zoology . Elsevier. https://doi.org/10.1016/j.zool.2016.03.006","mla":"Milutinovic, Barbara, et al. “Immune Priming in Arthropods: An Update Focusing on the Red Flour Beetle.” Zoology , vol. 119, no. 4, Elsevier, 2016, pp. 254–61, doi:10.1016/j.zool.2016.03.006.","ista":"Milutinovic B, Peuß R, Ferro K, Kurtz J. 2016. Immune priming in arthropods: an update focusing on the red flour beetle. Zoology . 119(4), 254–261.","chicago":"Milutinovic, Barbara, Robert Peuß, Kevin Ferro, and Joachim Kurtz. “Immune Priming in Arthropods: An Update Focusing on the Red Flour Beetle.” Zoology . Elsevier, 2016. https://doi.org/10.1016/j.zool.2016.03.006."},"project":[{"grant_number":"CR-118/3-1","name":"Host-Parasite Coevolution","_id":"25DAF0B2-B435-11E9-9278-68D0E5697425"}]},{"abstract":[{"text":"Down syndrome cell adhesion molecule 1 (Dscam1) has widereaching and vital neuronal functions although the role it plays in insect and crustacean immunity is less well understood. In this study, we combine different approaches to understand the roles that Dscam1 plays in fitness-related contexts in two model insect species. Contrary to our expectations, we found no short-term modulation of Dscam1 gene expression after haemocoelic or oral bacterial exposure in Tribolium castaneum, or after haemocoelic bacterial exposure in Drosophila melanogaster. Furthermore, RNAi-mediated Dscam1 knockdown and subsequent bacterial exposure did not reduce T. castaneum survival. However, Dscam1 knockdown in larvae resulted in adult locomotion defects, as well as dramatically reduced fecundity in males and females. We suggest that Dscam1 does not always play a straightforward role in immunity, but strongly influences behaviour and fecundity. This study takes a step towards understanding more about the role of this intriguing gene from different phenotypic perspectives.","lang":"eng"}],"oa_version":"Published Version","scopus_import":1,"intvolume":" 3","month":"04","publication_status":"published","language":[{"iso":"eng"}],"file":[{"file_size":627377,"date_updated":"2020-07-14T12:44:41Z","creator":"system","file_name":"IST-2016-704-v1+1_160138.full.pdf","date_created":"2018-12-12T10:14:01Z","content_type":"application/pdf","relation":"main_file","access_level":"open_access","file_id":"5049","checksum":"c3cd84666c8dc0ce6a784f1c82c1cf68"}],"volume":3,"issue":"4","_id":"1255","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","pubrep_id":"704","status":"public","date_updated":"2021-01-12T06:49:25Z","ddc":["576","592"],"department":[{"_id":"SyCr"}],"file_date_updated":"2020-07-14T12:44:41Z","acknowledgement":"We thank Dietmar Schmucker for reading a draft of this manuscript and thank him and his group for\r\nhelpful discussions. We thank Barbara Hasert, Kevin Ferro and Manuel F. Talarico for technical support and helpful\r\ndiscussions. We also thank two anonymous reviewers for their comments. This study was supported by grants from the Volkswagen Stiftung (1/83 516 and AZ 86020: both to S.A.O.A.) and from the DFG priority programme 1399 ‘Host parasite coevolution’ (KU 1929/4-2 to R.P. and J.K.).","oa":1,"publisher":"Royal Society, The","quality_controlled":"1","year":"2016","has_accepted_license":"1","publication":"Royal Society Open Science","day":"01","date_created":"2018-12-11T11:50:58Z","doi":"10.1098/rsos.160138","date_published":"2016-04-01T00:00:00Z","article_number":"160138","citation":{"mla":"Peuß, Robert, et al. “Down Syndrome Cell Adhesion Molecule 1: Testing for a Role in Insect Immunity, Behaviour and Reproduction.” Royal Society Open Science, vol. 3, no. 4, 160138, Royal Society, The, 2016, doi:10.1098/rsos.160138.","ama":"Peuß R, Wensing K, Woestmann L, et al. Down syndrome cell adhesion molecule 1: Testing for a role in insect immunity, behaviour and reproduction. Royal Society Open Science. 2016;3(4). doi:10.1098/rsos.160138","apa":"Peuß, R., Wensing, K., Woestmann, L., Eggert, H., Milutinovic, B., Sroka, M., … Armitage, S. (2016). Down syndrome cell adhesion molecule 1: Testing for a role in insect immunity, behaviour and reproduction. Royal Society Open Science. Royal Society, The. https://doi.org/10.1098/rsos.160138","short":"R. Peuß, K. Wensing, L. Woestmann, H. Eggert, B. Milutinovic, M. Sroka, J. Scharsack, J. Kurtz, S. Armitage, Royal Society Open Science 3 (2016).","ieee":"R. Peuß et al., “Down syndrome cell adhesion molecule 1: Testing for a role in insect immunity, behaviour and reproduction,” Royal Society Open Science, vol. 3, no. 4. Royal Society, The, 2016.","chicago":"Peuß, Robert, Kristina Wensing, Luisa Woestmann, Hendrik Eggert, Barbara Milutinovic, Marlene Sroka, Jörn Scharsack, Joachim Kurtz, and Sophie Armitage. “Down Syndrome Cell Adhesion Molecule 1: Testing for a Role in Insect Immunity, Behaviour and Reproduction.” Royal Society Open Science. Royal Society, The, 2016. https://doi.org/10.1098/rsos.160138.","ista":"Peuß R, Wensing K, Woestmann L, Eggert H, Milutinovic B, Sroka M, Scharsack J, Kurtz J, Armitage S. 2016. Down syndrome cell adhesion molecule 1: Testing for a role in insect immunity, behaviour and reproduction. Royal Society Open Science. 3(4), 160138."},"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","publist_id":"6070","author":[{"last_name":"Peuß","full_name":"Peuß, Robert","first_name":"Robert"},{"full_name":"Wensing, Kristina","last_name":"Wensing","first_name":"Kristina"},{"first_name":"Luisa","full_name":"Woestmann, Luisa","last_name":"Woestmann"},{"first_name":"Hendrik","full_name":"Eggert, Hendrik","last_name":"Eggert"},{"full_name":"Milutinovic, Barbara","orcid":"0000-0002-8214-4758","last_name":"Milutinovic","id":"2CDC32B8-F248-11E8-B48F-1D18A9856A87","first_name":"Barbara"},{"last_name":"Sroka","full_name":"Sroka, Marlene","first_name":"Marlene"},{"full_name":"Scharsack, Jörn","last_name":"Scharsack","first_name":"Jörn"},{"last_name":"Kurtz","full_name":"Kurtz, Joachim","first_name":"Joachim"},{"full_name":"Armitage, Sophie","last_name":"Armitage","first_name":"Sophie"}],"title":"Down syndrome cell adhesion molecule 1: Testing for a role in insect immunity, behaviour and reproduction"},{"doi":"10.1016/j.smim.2016.05.004","date_published":"2016-08-01T00:00:00Z","volume":28,"issue":"4","date_created":"2018-12-11T11:51:03Z","page":"328 - 342","day":"01","publication":"Seminars in Immunology","language":[{"iso":"eng"}],"year":"2016","publication_status":"published","month":"08","intvolume":" 28","quality_controlled":"1","publisher":"Academic Press","scopus_import":1,"oa_version":"None","acknowledgement":"We would like to thank Mihai Netea for inviting us to contribute to this Theme Issue.","title":"Immune memory in invertebrates","department":[{"_id":"SyCr"}],"author":[{"full_name":"Milutinovic, Barbara","orcid":"0000-0002-8214-4758","last_name":"Milutinovic","first_name":"Barbara","id":"2CDC32B8-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Kurtz","full_name":"Kurtz, Joachim","first_name":"Joachim"}],"publist_id":"6053","user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","date_updated":"2021-01-12T06:49:30Z","citation":{"ista":"Milutinovic B, Kurtz J. 2016. Immune memory in invertebrates. Seminars in Immunology. 28(4), 328–342.","chicago":"Milutinovic, Barbara, and Joachim Kurtz. “Immune Memory in Invertebrates.” Seminars in Immunology. Academic Press, 2016. https://doi.org/10.1016/j.smim.2016.05.004.","ieee":"B. Milutinovic and J. Kurtz, “Immune memory in invertebrates,” Seminars in Immunology, vol. 28, no. 4. Academic Press, pp. 328–342, 2016.","short":"B. Milutinovic, J. Kurtz, Seminars in Immunology 28 (2016) 328–342.","ama":"Milutinovic B, Kurtz J. Immune memory in invertebrates. Seminars in Immunology. 2016;28(4):328-342. doi:10.1016/j.smim.2016.05.004","apa":"Milutinovic, B., & Kurtz, J. (2016). Immune memory in invertebrates. Seminars in Immunology. Academic Press. https://doi.org/10.1016/j.smim.2016.05.004","mla":"Milutinovic, Barbara, and Joachim Kurtz. “Immune Memory in Invertebrates.” Seminars in Immunology, vol. 28, no. 4, Academic Press, 2016, pp. 328–42, doi:10.1016/j.smim.2016.05.004."},"status":"public","type":"journal_article","_id":"1268"},{"issue":"3","volume":2016,"publication_status":"published","language":[{"iso":"eng"}],"file":[{"date_created":"2018-12-12T10:17:19Z","file_name":"IST-2016-584-v1+1_peerj-1865.pdf","creator":"system","date_updated":"2020-07-14T12:44:53Z","file_size":1216360,"file_id":"5272","checksum":"c27d898598a1e3d7f629607a309254e1","access_level":"open_access","relation":"main_file","content_type":"application/pdf"}],"scopus_import":1,"intvolume":" 2016","month":"01","abstract":[{"text":"The rare socially parasitic butterfly Maculinea alcon occurs in two forms, which are characteristic of hygric or xeric habitats and which exploit different host plants and host ants. The status of these two forms has been the subject of considerable controversy. Populations of the two forms are usually spatially distinct, but at Răscruci in Romania both forms occur on the same site (syntopically). We examined the genetic differentiation between the two forms using eight microsatellite markers, and compared with a nearby hygric site, Şardu. Our results showed that while the two forms are strongly differentiated at Răscruci, it is the xeric form there that is most similar to the hygric form at Şardu, and Bayesian clustering algorithms suggest that these two populations have exchanged genes relatively recently. We found strong evidence for population substructuring, caused by high within host ant nest relatedness, indicating very limited dispersal of most ovipositing females, but not association with particular host ant species. Our results are consistent with the results of larger scale phylogeographic studies that suggest that the two forms represent local ecotypes specialising on different host plants, each with a distinct flowering phenology, providing a temporal rather than spatial barrier to gene flow.","lang":"eng"}],"oa_version":"Published Version","department":[{"_id":"SyCr"}],"file_date_updated":"2020-07-14T12:44:53Z","date_updated":"2021-01-12T06:50:41Z","ddc":["570"],"tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","pubrep_id":"584","status":"public","_id":"1431","date_created":"2018-12-11T11:51:59Z","doi":"10.7717/peerj.1865","date_published":"2016-01-01T00:00:00Z","year":"2016","has_accepted_license":"1","publication":"PeerJ","day":"01","oa":1,"publisher":"PeerJ","quality_controlled":"1","author":[{"first_name":"András","last_name":"Tartally","full_name":"Tartally, András"},{"first_name":"Andreas","full_name":"Kelager, Andreas","last_name":"Kelager"},{"first_name":"Matthias","id":"393B1196-F248-11E8-B48F-1D18A9856A87","last_name":"Fürst","full_name":"Fürst, Matthias","orcid":"0000-0002-3712-925X"},{"last_name":"Nash","full_name":"Nash, David","first_name":"David"}],"publist_id":"5767","title":"Host plant use drives genetic differentiation in syntopic populations of Maculinea alcon","citation":{"ista":"Tartally A, Kelager A, Fürst M, Nash D. 2016. Host plant use drives genetic differentiation in syntopic populations of Maculinea alcon. PeerJ. 2016(3), 1865.","chicago":"Tartally, András, Andreas Kelager, Matthias Fürst, and David Nash. “Host Plant Use Drives Genetic Differentiation in Syntopic Populations of Maculinea Alcon.” PeerJ. PeerJ, 2016. https://doi.org/10.7717/peerj.1865.","short":"A. Tartally, A. Kelager, M. Fürst, D. Nash, PeerJ 2016 (2016).","ieee":"A. Tartally, A. Kelager, M. Fürst, and D. Nash, “Host plant use drives genetic differentiation in syntopic populations of Maculinea alcon,” PeerJ, vol. 2016, no. 3. PeerJ, 2016.","apa":"Tartally, A., Kelager, A., Fürst, M., & Nash, D. (2016). Host plant use drives genetic differentiation in syntopic populations of Maculinea alcon. PeerJ. PeerJ. https://doi.org/10.7717/peerj.1865","ama":"Tartally A, Kelager A, Fürst M, Nash D. Host plant use drives genetic differentiation in syntopic populations of Maculinea alcon. PeerJ. 2016;2016(3). doi:10.7717/peerj.1865","mla":"Tartally, András, et al. “Host Plant Use Drives Genetic Differentiation in Syntopic Populations of Maculinea Alcon.” PeerJ, vol. 2016, no. 3, 1865, PeerJ, 2016, doi:10.7717/peerj.1865."},"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","article_number":"1865"},{"year":"2016","day":"22","date_created":"2021-07-26T09:14:19Z","related_material":{"record":[{"id":"1855","status":"public","relation":"used_in_publication"}]},"doi":"10.5061/dryad.4b565","date_published":"2016-01-22T00:00:00Z","abstract":[{"text":"Summary: Declining populations of bee pollinators are a cause of concern, with major repercussions for biodiversity loss and food security. RNA viruses associated with honeybees represent a potential threat to other insect pollinators, but the extent of this threat is poorly understood. This study aims to attain a detailed understanding of the current and ongoing risk of emerging infectious disease (EID) transmission between managed and wild pollinator species across a wide range of RNA viruses. Within a structured large-scale national survey across 26 independent sites, we quantify the prevalence and pathogen loads of multiple RNA viruses in co-occurring managed honeybee (Apis mellifera) and wild bumblebee (Bombus spp.) populations. We then construct models that compare virus prevalence between wild and managed pollinators. Multiple RNA viruses associated with honeybees are widespread in sympatric wild bumblebee populations. Virus prevalence in honeybees is a significant predictor of virus prevalence in bumblebees, but we remain cautious in speculating over the principle direction of pathogen transmission. We demonstrate species-specific differences in prevalence, indicating significant variation in disease susceptibility or tolerance. Pathogen loads within individual bumblebees may be high and in the case of at least one RNA virus, prevalence is higher in wild bumblebees than in managed honeybee populations. Our findings indicate widespread transmission of RNA viruses between managed and wild bee pollinators, pointing to an interconnected network of potential disease pressures within and among pollinator species. In the context of the biodiversity crisis, our study emphasizes the importance of targeting a wide range of pathogens and defining host associations when considering potential drivers of population decline.","lang":"eng"}],"oa_version":"Published Version","oa":1,"main_file_link":[{"url":"https://doi.org/10.5061/dryad.4b565","open_access":"1"}],"publisher":"Dryad","month":"01","citation":{"ista":"Mcmahon D, Fürst M, Caspar J, Theodorou P, Brown M, Paxton R. 2016. Data from: A sting in the spit: widespread cross-infection of multiple RNA viruses across wild and managed bees, Dryad, 10.5061/dryad.4b565.","chicago":"Mcmahon, Dino, Matthias Fürst, Jesicca Caspar, Panagiotis Theodorou, Mark Brown, and Robert Paxton. “Data from: A Sting in the Spit: Widespread Cross-Infection of Multiple RNA Viruses across Wild and Managed Bees.” Dryad, 2016. https://doi.org/10.5061/dryad.4b565.","short":"D. Mcmahon, M. Fürst, J. Caspar, P. Theodorou, M. Brown, R. Paxton, (2016).","ieee":"D. Mcmahon, M. Fürst, J. Caspar, P. Theodorou, M. Brown, and R. Paxton, “Data from: A sting in the spit: widespread cross-infection of multiple RNA viruses across wild and managed bees.” Dryad, 2016.","ama":"Mcmahon D, Fürst M, Caspar J, Theodorou P, Brown M, Paxton R. Data from: A sting in the spit: widespread cross-infection of multiple RNA viruses across wild and managed bees. 2016. doi:10.5061/dryad.4b565","apa":"Mcmahon, D., Fürst, M., Caspar, J., Theodorou, P., Brown, M., & Paxton, R. (2016). Data from: A sting in the spit: widespread cross-infection of multiple RNA viruses across wild and managed bees. Dryad. https://doi.org/10.5061/dryad.4b565","mla":"Mcmahon, Dino, et al. Data from: A Sting in the Spit: Widespread Cross-Infection of Multiple RNA Viruses across Wild and Managed Bees. Dryad, 2016, doi:10.5061/dryad.4b565."},"date_updated":"2023-02-23T10:17:25Z","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","article_processing_charge":"No","author":[{"full_name":"Mcmahon, Dino","last_name":"Mcmahon","first_name":"Dino"},{"last_name":"Fürst","orcid":"0000-0002-3712-925X","full_name":"Fürst, Matthias","first_name":"Matthias","id":"393B1196-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Caspar","full_name":"Caspar, Jesicca","first_name":"Jesicca"},{"first_name":"Panagiotis","full_name":"Theodorou, Panagiotis","last_name":"Theodorou"},{"full_name":"Brown, Mark","last_name":"Brown","first_name":"Mark"},{"last_name":"Paxton","full_name":"Paxton, Robert","first_name":"Robert"}],"department":[{"_id":"SyCr"}],"title":"Data from: A sting in the spit: widespread cross-infection of multiple RNA viruses across wild and managed bees","_id":"9720","type":"research_data_reference","status":"public"},{"acknowledgement":"This work was supported by the Federal Ministry of Food, Agriculture and Consumer Protection (Germany): Fit Bee project (grant 511-06.01-28-1-71.007-10), the EU: BeeDoc (grant 244956), iDiv (2013 NGS-Fast Track grant W47004118) and the Insect Pollinators Initiative (IPI grant BB/I000100/1 and BB/I000151/1). The IPI is funded jointly by the Biotechnology and Biological Sciences Research Council, the Department for Environment, Food and Rural Affairs, the Natural Environment Research Council, the Scottish Government and the Wellcome Trust, under the Living with Environmental Change Partnership. We thank A. Abrahams, M. Husemann and A. Soro\r\nfor support in obtaining\r\nV. destructor\r\n-free honeybees; and BBKA\r\nPresident D. Aston for access to records of colony overwinter\r\n2011–2012 mortality in the UK. We also thank the anonymous refe-\r\nrees and Stephen Martin for comments that led to substantial\r\nimprovement of the manuscript.","oa":1,"quality_controlled":"1","publisher":"Royal Society, The","year":"2016","has_accepted_license":"1","publication":"Proceedings of the Royal Society of London Series B Biological Sciences","day":"29","date_created":"2018-12-11T11:51:00Z","doi":"10.1098/rspb.2016.0811","date_published":"2016-06-29T00:00:00Z","article_number":"20160811","citation":{"chicago":"Mcmahon, Dino, Myrsini Natsopoulou, Vincent Doublet, Matthias Fürst, Silvio Weging, Mark Brown, Andreas Gogol Döring, and Robert Paxton. “Elevated Virulence of an Emerging Viral Genotype as a Driver of Honeybee Loss.” Proceedings of the Royal Society of London Series B Biological Sciences. Royal Society, The, 2016. https://doi.org/10.1098/rspb.2016.0811.","ista":"Mcmahon D, Natsopoulou M, Doublet V, Fürst M, Weging S, Brown M, Gogol Döring A, Paxton R. 2016. Elevated virulence of an emerging viral genotype as a driver of honeybee loss. Proceedings of the Royal Society of London Series B Biological Sciences. 283(1833), 20160811.","mla":"Mcmahon, Dino, et al. “Elevated Virulence of an Emerging Viral Genotype as a Driver of Honeybee Loss.” Proceedings of the Royal Society of London Series B Biological Sciences, vol. 283, no. 1833, 20160811, Royal Society, The, 2016, doi:10.1098/rspb.2016.0811.","short":"D. Mcmahon, M. Natsopoulou, V. Doublet, M. Fürst, S. Weging, M. Brown, A. Gogol Döring, R. Paxton, Proceedings of the Royal Society of London Series B Biological Sciences 283 (2016).","ieee":"D. Mcmahon et al., “Elevated virulence of an emerging viral genotype as a driver of honeybee loss,” Proceedings of the Royal Society of London Series B Biological Sciences, vol. 283, no. 1833. Royal Society, The, 2016.","ama":"Mcmahon D, Natsopoulou M, Doublet V, et al. Elevated virulence of an emerging viral genotype as a driver of honeybee loss. Proceedings of the Royal Society of London Series B Biological Sciences. 2016;283(1833). doi:10.1098/rspb.2016.0811","apa":"Mcmahon, D., Natsopoulou, M., Doublet, V., Fürst, M., Weging, S., Brown, M., … Paxton, R. (2016). Elevated virulence of an emerging viral genotype as a driver of honeybee loss. Proceedings of the Royal Society of London Series B Biological Sciences. Royal Society, The. https://doi.org/10.1098/rspb.2016.0811"},"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","author":[{"full_name":"Mcmahon, Dino","last_name":"Mcmahon","first_name":"Dino"},{"full_name":"Natsopoulou, Myrsini","last_name":"Natsopoulou","first_name":"Myrsini"},{"first_name":"Vincent","last_name":"Doublet","full_name":"Doublet, Vincent"},{"full_name":"Fürst, Matthias","orcid":"0000-0002-3712-925X","last_name":"Fürst","first_name":"Matthias","id":"393B1196-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Weging","full_name":"Weging, Silvio","first_name":"Silvio"},{"full_name":"Brown, Mark","last_name":"Brown","first_name":"Mark"},{"last_name":"Gogol Döring","full_name":"Gogol Döring, Andreas","first_name":"Andreas"},{"first_name":"Robert","full_name":"Paxton, Robert","last_name":"Paxton"}],"publist_id":"6060","title":"Elevated virulence of an emerging viral genotype as a driver of honeybee loss","abstract":[{"text":"Emerging infectious diseases (EIDs) have contributed significantly to the current biodiversity crisis, leading to widespread epidemics and population loss. Owing to genetic variation in pathogen virulence, a complete understanding of species decline requires the accurate identification and characterization of EIDs. We explore this issue in the Western honeybee, where increasing mortality of populations in the Northern Hemisphere has caused major concern. Specifically, we investigate the importance of genetic identity of the main suspect in mortality, deformed wing virus (DWV), in driving honeybee loss. Using laboratory experiments and a systematic field survey, we demonstrate that an emerging DWV genotype (DWV-B) is more virulent than the established DWV genotype (DWV-A) and is widespread in the landscape. Furthermore, we show in a simple model that colonies infected with DWV-B collapse sooner than colonies infected with DWV-A. We also identify potential for rapid DWV evolution by revealing extensive genome-wide recombination in vivo. The emergence of DWV-B in naive honeybee populations, including via recombination with DWV-A, could be of significant ecological and economic importance. Our findings emphasize that knowledge of pathogen genetic identity and diversity is critical to understanding drivers of species decline.","lang":"eng"}],"oa_version":"Published Version","scopus_import":1,"intvolume":" 283","month":"06","publication_status":"published","language":[{"iso":"eng"}],"file":[{"file_name":"IST-2016-701-v1+1_20160811.full.pdf","date_created":"2018-12-12T10:08:46Z","creator":"system","file_size":796872,"date_updated":"2020-07-14T12:44:42Z","file_id":"4708","checksum":"0b0d1be38b497d004064650acb3baced","relation":"main_file","access_level":"open_access","content_type":"application/pdf"}],"related_material":{"record":[{"relation":"research_data","status":"public","id":"9704"}]},"volume":283,"issue":"1833","_id":"1262","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","pubrep_id":"701","status":"public","date_updated":"2023-02-23T14:05:30Z","ddc":["576","592"],"department":[{"_id":"SyCr"}],"file_date_updated":"2020-07-14T12:44:42Z"},{"type":"research_data_reference","status":"public","_id":"9704","article_processing_charge":"No","author":[{"first_name":"Dino","last_name":"Mcmahon","full_name":"Mcmahon, Dino"},{"first_name":"Myrsini","full_name":"Natsopoulou, Myrsini","last_name":"Natsopoulou"},{"full_name":"Doublet, Vincent","last_name":"Doublet","first_name":"Vincent"},{"first_name":"Matthias","id":"393B1196-F248-11E8-B48F-1D18A9856A87","last_name":"Fürst","full_name":"Fürst, Matthias","orcid":"0000-0002-3712-925X"},{"last_name":"Weging","full_name":"Weging, Silvio","first_name":"Silvio"},{"full_name":"Brown, Mark","last_name":"Brown","first_name":"Mark"},{"full_name":"Gogol Döring, Andreas","last_name":"Gogol Döring","first_name":"Andreas"},{"last_name":"Paxton","full_name":"Paxton, Robert","first_name":"Robert"}],"title":"Data from: Elevated virulence of an emerging viral genotype as a driver of honeybee loss","department":[{"_id":"SyCr"}],"citation":{"mla":"Mcmahon, Dino, et al. Data from: Elevated Virulence of an Emerging Viral Genotype as a Driver of Honeybee Loss. Dryad, 2016, doi:10.5061/dryad.cq7t1.","ama":"Mcmahon D, Natsopoulou M, Doublet V, et al. Data from: Elevated virulence of an emerging viral genotype as a driver of honeybee loss. 2016. doi:10.5061/dryad.cq7t1","apa":"Mcmahon, D., Natsopoulou, M., Doublet, V., Fürst, M., Weging, S., Brown, M., … Paxton, R. (2016). Data from: Elevated virulence of an emerging viral genotype as a driver of honeybee loss. Dryad. https://doi.org/10.5061/dryad.cq7t1","ieee":"D. Mcmahon et al., “Data from: Elevated virulence of an emerging viral genotype as a driver of honeybee loss.” Dryad, 2016.","short":"D. Mcmahon, M. Natsopoulou, V. Doublet, M. Fürst, S. Weging, M. Brown, A. Gogol Döring, R. Paxton, (2016).","chicago":"Mcmahon, Dino, Myrsini Natsopoulou, Vincent Doublet, Matthias Fürst, Silvio Weging, Mark Brown, Andreas Gogol Döring, and Robert Paxton. “Data from: Elevated Virulence of an Emerging Viral Genotype as a Driver of Honeybee Loss.” Dryad, 2016. https://doi.org/10.5061/dryad.cq7t1.","ista":"Mcmahon D, Natsopoulou M, Doublet V, Fürst M, Weging S, Brown M, Gogol Döring A, Paxton R. 2016. Data from: Elevated virulence of an emerging viral genotype as a driver of honeybee loss, Dryad, 10.5061/dryad.cq7t1."},"date_updated":"2023-02-21T16:54:31Z","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","oa":1,"main_file_link":[{"open_access":"1","url":"https://doi.org/10.5061/dryad.cq7t1"}],"publisher":"Dryad","month":"05","abstract":[{"lang":"eng","text":"Emerging infectious diseases (EIDs) have contributed significantly to the current biodiversity crisis, leading to widespread epidemics and population loss. Owing to genetic variation in pathogen virulence, a complete understanding of species decline requires the accurate identification and characterization of EIDs. We explore this issue in the Western honeybee, where increasing mortality of populations in the Northern Hemisphere has caused major concern. Specifically, we investigate the importance of genetic identity of the main suspect in mortality, deformed wing virus (DWV), in driving honeybee loss. Using laboratory experiments and a systematic field survey, we demonstrate that an emerging DWV genotype (DWV-B) is more virulent than the established DWV genotype (DWV-A) and is widespread in the landscape. Furthermore, we show in a simple model that colonies infected with DWV-B collapse sooner than colonies infected with DWV-A. We also identify potential for rapid DWV evolution by revealing extensive genome-wide recombination in vivo. The emergence of DWV-B in naive honeybee populations, including via recombination with DWV-A, could be of significant ecological and economic importance. Our findings emphasize that knowledge of pathogen genetic identity and diversity is critical to understanding drivers of species decline."}],"oa_version":"Published Version","date_created":"2021-07-23T08:30:38Z","related_material":{"record":[{"id":"1262","status":"public","relation":"used_in_publication"}]},"date_published":"2016-05-06T00:00:00Z","doi":"10.5061/dryad.cq7t1","year":"2016","day":"06"},{"acknowledgement":"We are very grateful for funding from the German Science Foundation (DFG) to HS (SCHU 1415/8, SCHU 1415/9), PR (RO 2994/3), EBB (BO 2544/7), HL (LI 1690/2), AT (TE 976/2), RDS (SCHU 2522/1), JK (KU 1929/4); from the Kiel Excellence Cluster Inflammation at Interfaces to HS and PR; and from the ISTFELLOW program (Co-fund Marie Curie Actions of the European Commission) to LM.","oa":1,"publisher":"Public Library of Science","quality_controlled":"1","publication":"PLoS Biology","day":"04","year":"2015","has_accepted_license":"1","date_created":"2018-12-11T11:52:40Z","doi":"10.1371/journal.pbio.1002169","date_published":"2015-06-04T00:00:00Z","page":"1 - 30","project":[{"call_identifier":"FP7","_id":"25681D80-B435-11E9-9278-68D0E5697425","grant_number":"291734","name":"International IST Postdoc Fellowship Programme"}],"user_id":"3E5EF7F0-F248-11E8-B48F-1D18A9856A87","citation":{"mla":"El Masri, Leila, et al. “Host–Pathogen Coevolution: The Selective Advantage of Bacillus Thuringiensis Virulence and Its Cry Toxin Genes.” PLoS Biology, vol. 13, no. 6, Public Library of Science, 2015, pp. 1–30, doi:10.1371/journal.pbio.1002169.","apa":"El Masri, L., Branca, A., Sheppard, A., Papkou, A., Laehnemann, D., Guenther, P., … Schulenburg, H. (2015). Host–pathogen coevolution: The selective advantage of Bacillus thuringiensis virulence and its cry toxin genes. PLoS Biology. Public Library of Science. https://doi.org/10.1371/journal.pbio.1002169","ama":"El Masri L, Branca A, Sheppard A, et al. Host–pathogen coevolution: The selective advantage of Bacillus thuringiensis virulence and its cry toxin genes. PLoS Biology. 2015;13(6):1-30. doi:10.1371/journal.pbio.1002169","ieee":"L. El Masri et al., “Host–pathogen coevolution: The selective advantage of Bacillus thuringiensis virulence and its cry toxin genes,” PLoS Biology, vol. 13, no. 6. Public Library of Science, pp. 1–30, 2015.","short":"L. El Masri, A. Branca, A. Sheppard, A. Papkou, D. Laehnemann, P. Guenther, S. Prahl, M. Saebelfeld, J. Hollensteiner, H. Liesegang, E. Brzuszkiewicz, R. Daniel, N. Michiels, R. Schulte, J. Kurtz, P. Rosenstiel, A. Telschow, E. Bornberg Bauer, H. Schulenburg, PLoS Biology 13 (2015) 1–30.","chicago":"El Masri, Leila, Antoine Branca, Anna Sheppard, Andrei Papkou, David Laehnemann, Patrick Guenther, Swantje Prahl, et al. “Host–Pathogen Coevolution: The Selective Advantage of Bacillus Thuringiensis Virulence and Its Cry Toxin Genes.” PLoS Biology. Public Library of Science, 2015. https://doi.org/10.1371/journal.pbio.1002169.","ista":"El Masri L, Branca A, Sheppard A, Papkou A, Laehnemann D, Guenther P, Prahl S, Saebelfeld M, Hollensteiner J, Liesegang H, Brzuszkiewicz E, Daniel R, Michiels N, Schulte R, Kurtz J, Rosenstiel P, Telschow A, Bornberg Bauer E, Schulenburg H. 2015. Host–pathogen coevolution: The selective advantage of Bacillus thuringiensis virulence and its cry toxin genes. PLoS Biology. 13(6), 1–30."},"title":"Host–pathogen coevolution: The selective advantage of Bacillus thuringiensis virulence and its cry toxin genes","author":[{"first_name":"Leila","id":"349A6E66-F248-11E8-B48F-1D18A9856A87","full_name":"El Masri, Leila","last_name":"El Masri"},{"last_name":"Branca","full_name":"Branca, Antoine","first_name":"Antoine"},{"full_name":"Sheppard, Anna","last_name":"Sheppard","first_name":"Anna"},{"last_name":"Papkou","full_name":"Papkou, Andrei","first_name":"Andrei"},{"first_name":"David","full_name":"Laehnemann, David","last_name":"Laehnemann"},{"first_name":"Patrick","full_name":"Guenther, Patrick","last_name":"Guenther"},{"first_name":"Swantje","full_name":"Prahl, Swantje","last_name":"Prahl"},{"first_name":"Manja","full_name":"Saebelfeld, Manja","last_name":"Saebelfeld"},{"first_name":"Jacqueline","last_name":"Hollensteiner","full_name":"Hollensteiner, Jacqueline"},{"last_name":"Liesegang","full_name":"Liesegang, Heiko","first_name":"Heiko"},{"first_name":"Elzbieta","last_name":"Brzuszkiewicz","full_name":"Brzuszkiewicz, Elzbieta"},{"first_name":"Rolf","last_name":"Daniel","full_name":"Daniel, Rolf"},{"last_name":"Michiels","full_name":"Michiels, Nico","first_name":"Nico"},{"full_name":"Schulte, Rebecca","last_name":"Schulte","first_name":"Rebecca"},{"first_name":"Joachim","last_name":"Kurtz","full_name":"Kurtz, Joachim"},{"last_name":"Rosenstiel","full_name":"Rosenstiel, Philip","first_name":"Philip"},{"full_name":"Telschow, Arndt","last_name":"Telschow","first_name":"Arndt"},{"first_name":"Erich","last_name":"Bornberg Bauer","full_name":"Bornberg Bauer, Erich"},{"full_name":"Schulenburg, Hinrich","last_name":"Schulenburg","first_name":"Hinrich"}],"publist_id":"5620","oa_version":"Published Version","abstract":[{"lang":"eng","text":"Reciprocal coevolution between host and pathogen is widely seen as a major driver of evolution and biological innovation. Yet, to date, the underlying genetic mechanisms and associated trait functions that are unique to rapid coevolutionary change are generally unknown. We here combined experimental evolution of the bacterial biocontrol agent Bacillus thuringiensis and its nematode host Caenorhabditis elegans with large-scale phenotyping, whole genome analysis, and functional genetics to demonstrate the selective benefit of pathogen virulence and the underlying toxin genes during the adaptation process. We show that: (i) high virulence was specifically favoured during pathogen–host coevolution rather than pathogen one-sided adaptation to a nonchanging host or to an environment without host; (ii) the pathogen genotype BT-679 with known nematocidal toxin genes and high virulence specifically swept to fixation in all of the independent replicate populations under coevolution but only some under one-sided adaptation; (iii) high virulence in the BT-679-dominated populations correlated with elevated copy numbers of the plasmid containing the nematocidal toxin genes; (iv) loss of virulence in a toxin-plasmid lacking BT-679 isolate was reconstituted by genetic reintroduction or external addition of the toxins.We conclude that sustained coevolution is distinct from unidirectional selection in shaping the pathogen's genome and life history characteristics. To our knowledge, this study is the first to characterize the pathogen genes involved in coevolutionary adaptation in an animal host–pathogen interaction system."}],"intvolume":" 13","month":"06","scopus_import":1,"language":[{"iso":"eng"}],"file":[{"file_id":"5063","checksum":"30dee7a2c11ed09f2f5634655c0146f8","content_type":"application/pdf","relation":"main_file","access_level":"open_access","file_name":"IST-2016-481-v1+1_journal.pbio.1002169.pdf","date_created":"2018-12-12T10:14:13Z","file_size":3468956,"date_updated":"2020-07-14T12:45:02Z","creator":"system"}],"publication_status":"published","ec_funded":1,"issue":"6","volume":13,"_id":"1551","pubrep_id":"481","status":"public","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","ddc":["570"],"date_updated":"2021-01-12T06:51:33Z","file_date_updated":"2020-07-14T12:45:02Z","department":[{"_id":"SyCr"}]},{"department":[{"_id":"SyCr"}],"date_updated":"2021-01-12T06:51:31Z","type":"journal_article","status":"public","_id":"1548","volume":81,"issue":"23","publication_status":"published","language":[{"iso":"eng"}],"main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4651099/"}],"scopus_import":1,"intvolume":" 81","month":"12","abstract":[{"lang":"eng","text":"Reproduction within a host and transmission to the next host are crucial for the virulence and fitness of pathogens. Nevertheless, basic knowledge about such parameters is often missing from the literature, even for well-studied bacteria, such as Bacillus thuringiensis, an endospore-forming insect pathogen, which infects its hosts via the oral route. To characterize bacterial replication success, we made use of an experimental oral infection system for the red flour beetle Tribolium castaneum and developed a flow cytometric assay for the quantification of both spore ingestion by the individual beetle larvae and the resulting spore load after bacterial replication and resporulation within cadavers. On average, spore numbers increased 460-fold, showing that Bacillus thuringiensis grows and replicates successfully in insect cadavers. By inoculating cadaver-derived spores and spores from bacterial stock cultures into nutrient medium, we next investigated outgrowth characteristics of vegetative cells and found that cadaver- derived bacteria showed reduced growth compared to bacteria from the stock cultures. Interestingly, this reduced growth was a consequence of inhibited spore germination, probably originating from the host and resulting in reduced host mortality in subsequent infections by cadaver-derived spores. Nevertheless, we further showed that Bacillus thuringiensis transmission was possible via larval cannibalism when no other food was offered. These results contribute to our understanding of the ecology of Bacillus thuringiensis as an insect pathogen."}],"pmid":1,"oa_version":"Submitted Version","external_id":{"pmid":["26386058"]},"author":[{"orcid":"0000-0002-8214-4758","full_name":"Milutinovic, Barbara","last_name":"Milutinovic","id":"2CDC32B8-F248-11E8-B48F-1D18A9856A87","first_name":"Barbara"},{"first_name":"Christina","last_name":"Höfling","full_name":"Höfling, Christina"},{"full_name":"Futo, Momir","last_name":"Futo","first_name":"Momir"},{"last_name":"Scharsack","full_name":"Scharsack, Jörn","first_name":"Jörn"},{"last_name":"Kurtz","full_name":"Kurtz, Joachim","first_name":"Joachim"}],"publist_id":"5623","title":"Infection of Tribolium castaneum with Bacillus thuringiensis: Quantification of bacterial replication within cadavers, transmission via cannibalism, and inhibition of spore germination","citation":{"short":"B. Milutinovic, C. Höfling, M. Futo, J. Scharsack, J. Kurtz, Applied and Environmental Microbiology 81 (2015) 8135–8144.","ieee":"B. Milutinovic, C. Höfling, M. Futo, J. Scharsack, and J. Kurtz, “Infection of Tribolium castaneum with Bacillus thuringiensis: Quantification of bacterial replication within cadavers, transmission via cannibalism, and inhibition of spore germination,” Applied and Environmental Microbiology, vol. 81, no. 23. American Society for Microbiology, pp. 8135–8144, 2015.","apa":"Milutinovic, B., Höfling, C., Futo, M., Scharsack, J., & Kurtz, J. (2015). Infection of Tribolium castaneum with Bacillus thuringiensis: Quantification of bacterial replication within cadavers, transmission via cannibalism, and inhibition of spore germination. Applied and Environmental Microbiology. American Society for Microbiology. https://doi.org/10.1128/AEM.02051-15","ama":"Milutinovic B, Höfling C, Futo M, Scharsack J, Kurtz J. Infection of Tribolium castaneum with Bacillus thuringiensis: Quantification of bacterial replication within cadavers, transmission via cannibalism, and inhibition of spore germination. Applied and Environmental Microbiology. 2015;81(23):8135-8144. doi:10.1128/AEM.02051-15","mla":"Milutinovic, Barbara, et al. “Infection of Tribolium Castaneum with Bacillus Thuringiensis: Quantification of Bacterial Replication within Cadavers, Transmission via Cannibalism, and Inhibition of Spore Germination.” Applied and Environmental Microbiology, vol. 81, no. 23, American Society for Microbiology, 2015, pp. 8135–44, doi:10.1128/AEM.02051-15.","ista":"Milutinovic B, Höfling C, Futo M, Scharsack J, Kurtz J. 2015. Infection of Tribolium castaneum with Bacillus thuringiensis: Quantification of bacterial replication within cadavers, transmission via cannibalism, and inhibition of spore germination. Applied and Environmental Microbiology. 81(23), 8135–8144.","chicago":"Milutinovic, Barbara, Christina Höfling, Momir Futo, Jörn Scharsack, and Joachim Kurtz. “Infection of Tribolium Castaneum with Bacillus Thuringiensis: Quantification of Bacterial Replication within Cadavers, Transmission via Cannibalism, and Inhibition of Spore Germination.” Applied and Environmental Microbiology. American Society for Microbiology, 2015. https://doi.org/10.1128/AEM.02051-15."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","page":"8135 - 8144","date_created":"2018-12-11T11:52:39Z","date_published":"2015-12-01T00:00:00Z","doi":"10.1128/AEM.02051-15","year":"2015","publication":"Applied and Environmental Microbiology","day":"01","oa":1,"publisher":"American Society for Microbiology","quality_controlled":"1"},{"author":[{"first_name":"Peter","last_name":"Kappeler","full_name":"Kappeler, Peter"},{"last_name":"Cremer","full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","first_name":"Sylvia"},{"first_name":"Charles","last_name":"Nunn","full_name":"Nunn, Charles"}],"publist_id":"5272","external_id":{"pmid":["25870402"]},"title":"Sociality and health: Impacts of sociality on disease susceptibility and transmission in animal and human societies","citation":{"chicago":"Kappeler, Peter, Sylvia Cremer, and Charles Nunn. “Sociality and Health: Impacts of Sociality on Disease Susceptibility and Transmission in Animal and Human Societies.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Royal Society, 2015. https://doi.org/10.1098/rstb.2014.0116.","ista":"Kappeler P, Cremer S, Nunn C. 2015. Sociality and health: Impacts of sociality on disease susceptibility and transmission in animal and human societies. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. 370(1669), 20140116.","mla":"Kappeler, Peter, et al. “Sociality and Health: Impacts of Sociality on Disease Susceptibility and Transmission in Animal and Human Societies.” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 370, no. 1669, 20140116, Royal Society, 2015, doi:10.1098/rstb.2014.0116.","short":"P. Kappeler, S. Cremer, C. Nunn, Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences 370 (2015).","ieee":"P. Kappeler, S. Cremer, and C. Nunn, “Sociality and health: Impacts of sociality on disease susceptibility and transmission in animal and human societies,” Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences, vol. 370, no. 1669. Royal Society, 2015.","apa":"Kappeler, P., Cremer, S., & Nunn, C. (2015). Sociality and health: Impacts of sociality on disease susceptibility and transmission in animal and human societies. Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences. Royal Society. https://doi.org/10.1098/rstb.2014.0116","ama":"Kappeler P, Cremer S, Nunn C. Sociality and health: Impacts of sociality on disease susceptibility and transmission in animal and human societies. Philosophical Transactions of the Royal Society of London Series B, Biological Sciences. 2015;370(1669). doi:10.1098/rstb.2014.0116"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","article_number":"20140116","doi":"10.1098/rstb.2014.0116","date_published":"2015-05-01T00:00:00Z","date_created":"2018-12-11T11:54:15Z","year":"2015","day":"01","publication":"Philosophical Transactions of the Royal Society of London. Series B, Biological Sciences","quality_controlled":"1","publisher":"Royal Society","oa":1,"acknowledgement":"We thank the German Research Foundation (DFG), the Ministry of Science and Culture of Lower-Saxony (MWK Hannover) and the German Primate Centre (DPZ) for their support of the 9. Göttinger Freilandtage in 2013, a conference at which most contributions to this issue were first presented, the referees of the contributions to this issue for their constructive comments, Meggan Craft for comments, and Helen Eaton for her support in producing this theme issue.","department":[{"_id":"SyCr"}],"date_updated":"2021-01-12T06:53:29Z","type":"journal_article","status":"public","_id":"1831","volume":370,"issue":"1669","publication_status":"published","language":[{"iso":"eng"}],"scopus_import":1,"main_file_link":[{"open_access":"1","url":"http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4410382/"}],"month":"05","intvolume":" 370","abstract":[{"lang":"eng","text":"This paper introduces a theme issue presenting the latest developments in research on the impacts of sociality on health and fitness. The articles that follow cover research on societies ranging from insects to humans. Variation in measures of fitness (i.e. survival and reproduction) has been linked to various aspects of sociality in humans and animals alike, and variability in individual health and condition has been recognized as a key mediator of these relationships. Viewed from a broad evolutionary perspective, the evolutionary transitions from a solitary lifestyle to group living have resulted in several new health-related costs and benefits of sociality. Social transmission of parasites within groups represents a major cost of group living, but some behavioural mechanisms, such as grooming, have evolved repeatedly to reduce this cost. Group living also has created novel costs in terms of altered susceptibility to infectious and non-infectious disease as a result of the unavoidable physiological consequences of social competition and integration, which are partly alleviated by social buffering in some vertebrates. Here, we define the relevant aspects of sociality, summarize their health-related costs and benefits, and discuss possible fitness measures in different study systems. Given the pervasive effects of social factors on health and fitness, we propose a synthesis of existing conceptual approaches in disease ecology, ecological immunology and behavioural neurosciences by adding sociality as a key factor, with the goal to generate a broader framework for organismal integration of health-related research."}],"oa_version":"Submitted Version","pmid":1},{"ec_funded":1,"issue":"5","volume":372,"publication_status":"published","language":[{"iso":"eng"}],"file":[{"file_id":"5326","checksum":"3c0dcacc900bc45cc65a453dfda4ca43","relation":"main_file","access_level":"open_access","content_type":"application/pdf","file_name":"IST-2015-329-v1+1_manuscript.pdf","date_created":"2018-12-12T10:18:07Z","creator":"system","file_size":1546914,"date_updated":"2020-07-14T12:45:19Z"}],"scopus_import":1,"intvolume":" 372","month":"05","abstract":[{"lang":"eng","text":"Entomopathogenic fungi are potent biocontrol agents that are widely used against insect pests, many of which are social insects. Nevertheless, theoretical investigations of their particular life history are scarce. We develop a model that takes into account the main distinguishing features between traditionally studied diseases and obligate killing pathogens, like the (biocontrol-relevant) insect-pathogenic fungi Metarhizium and Beauveria. First, obligate killing entomopathogenic fungi produce new infectious particles (conidiospores) only after host death and not yet on the living host. Second, the killing rates of entomopathogenic fungi depend strongly on the initial exposure dosage, thus we explicitly consider the pathogen load of individual hosts. Further, we make the model applicable not only to solitary host species, but also to group living species by incorporating social interactions between hosts, like the collective disease defences of insect societies. Our results identify the optimal killing rate for the pathogen that minimises its invasion threshold. Furthermore, we find that the rate of contact between hosts has an ambivalent effect: dense interaction networks between individuals are considered to facilitate disease outbreaks because of increased pathogen transmission. In social insects, this is compensated by their collective disease defences, i.e., social immunity. For the type of pathogens considered here, we show that even without social immunity, high contact rates between live individuals dilute the pathogen in the host colony and hence can reduce individual pathogen loads below disease-causing levels."}],"oa_version":"Submitted Version","file_date_updated":"2020-07-14T12:45:19Z","department":[{"_id":"NiBa"},{"_id":"SyCr"}],"date_updated":"2021-01-12T06:53:37Z","ddc":["576"],"type":"journal_article","pubrep_id":"329","status":"public","_id":"1850","page":"54 - 64","date_created":"2018-12-11T11:54:21Z","date_published":"2015-05-07T00:00:00Z","doi":"10.1016/j.jtbi.2015.02.018","year":"2015","has_accepted_license":"1","publication":"Journal of Theoretical Biology","day":"07","oa":1,"quality_controlled":"1","publisher":"Elsevier","author":[{"full_name":"Novak, Sebastian","last_name":"Novak","id":"461468AE-F248-11E8-B48F-1D18A9856A87","first_name":"Sebastian"},{"full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868","last_name":"Cremer","first_name":"Sylvia","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87"}],"publist_id":"5251","title":"Fungal disease dynamics in insect societies: Optimal killing rates and the ambivalent effect of high social interaction rates","citation":{"ista":"Novak S, Cremer S. 2015. Fungal disease dynamics in insect societies: Optimal killing rates and the ambivalent effect of high social interaction rates. Journal of Theoretical Biology. 372(5), 54–64.","chicago":"Novak, Sebastian, and Sylvia Cremer. “Fungal Disease Dynamics in Insect Societies: Optimal Killing Rates and the Ambivalent Effect of High Social Interaction Rates.” Journal of Theoretical Biology. Elsevier, 2015. https://doi.org/10.1016/j.jtbi.2015.02.018.","short":"S. Novak, S. Cremer, Journal of Theoretical Biology 372 (2015) 54–64.","ieee":"S. Novak and S. Cremer, “Fungal disease dynamics in insect societies: Optimal killing rates and the ambivalent effect of high social interaction rates,” Journal of Theoretical Biology, vol. 372, no. 5. Elsevier, pp. 54–64, 2015.","apa":"Novak, S., & Cremer, S. (2015). Fungal disease dynamics in insect societies: Optimal killing rates and the ambivalent effect of high social interaction rates. Journal of Theoretical Biology. Elsevier. https://doi.org/10.1016/j.jtbi.2015.02.018","ama":"Novak S, Cremer S. Fungal disease dynamics in insect societies: Optimal killing rates and the ambivalent effect of high social interaction rates. Journal of Theoretical Biology. 2015;372(5):54-64. doi:10.1016/j.jtbi.2015.02.018","mla":"Novak, Sebastian, and Sylvia Cremer. “Fungal Disease Dynamics in Insect Societies: Optimal Killing Rates and the Ambivalent Effect of High Social Interaction Rates.” Journal of Theoretical Biology, vol. 372, no. 5, Elsevier, 2015, pp. 54–64, doi:10.1016/j.jtbi.2015.02.018."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","project":[{"call_identifier":"FP7","_id":"25B07788-B435-11E9-9278-68D0E5697425","name":"Limits to selection in biology and in evolutionary computation","grant_number":"250152"},{"_id":"25DC711C-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","grant_number":"243071","name":"Social Vaccination in Ant Colonies: from Individual Mechanisms to Society Effects"}]}]