[{"oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"external_id":{"pmid":["38096816"]},"project":[{"grant_number":"F07805","_id":"059F6AB4-7A3F-11EA-A408-12923DDC885E","name":"Molecular Mechanisms of Neural Stem Cell Lineage Progression"}],"quality_controlled":"1","doi":"10.1016/j.neuron.2023.11.009","language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"Bio"},{"_id":"M-Shop"},{"_id":"LifeSc"},{"_id":"PreCl"}],"publication_identifier":{"issn":["0896-6273"]},"month":"01","pmid":1,"year":"2024","acknowledgement":"We thank Liqun Luo for his continued support, for providing essential resources for generating Fzd10-CreER mice which were generated in his laboratory, and for comments on the manuscript; W. Zhong for providing Nestin-Cre transgenic mouse line for this study; A. Heger for mouse colony management; R. Beattie and T. Asenov for designing and producing components of acute slice recovery chamber for MADM-CloneSeq experiments; and K. Leopold, J. Rodarte and N. Amberg for initial experiments, technical support and/or assistance. This study was supported by the Scientific Service Units (SSU) of IST Austria through resources provided by the Imaging & Optics Facility (IOF), Laboratory Support Facility (LSF), Miba Machine Shop, and Pre-clinical Facility (PCF). G.C. received funding from European Commission (IST plus postdoctoral fellowship). This work was supported by ISTA institutional\r\nfunds; the Austrian Science Fund Special Research Programmes (FWF SFB F78 Neuro Stem Modulation) to S.H. ","department":[{"_id":"SiHi"},{"_id":"RySh"}],"publisher":"Elsevier","publication_status":"published","related_material":{"link":[{"url":"https://ista.ac.at/en/news/the-pedigree-of-brain-cells/","description":"News on ISTA Website","relation":"press_release"}]},"author":[{"full_name":"Cheung, Giselle T","first_name":"Giselle T","last_name":"Cheung","id":"471195F6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8457-2572"},{"full_name":"Pauler, Florian","last_name":"Pauler","first_name":"Florian","orcid":"0000-0002-7462-0048","id":"48EA0138-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Koppensteiner, Peter","first_name":"Peter","last_name":"Koppensteiner","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3509-1948"},{"last_name":"Krausgruber","first_name":"Thomas","full_name":"Krausgruber, Thomas"},{"first_name":"Carmen","last_name":"Streicher","id":"36BCB99C-F248-11E8-B48F-1D18A9856A87","full_name":"Streicher, Carmen"},{"first_name":"Martin","last_name":"Schrammel","id":"f13e7cae-e8bd-11ed-841a-96dedf69f46d","full_name":"Schrammel, Martin"},{"last_name":"Özgen","first_name":"Natalie Y","id":"e68ece33-f6e0-11ea-865d-ae1031dcc090","full_name":"Özgen, Natalie Y"},{"full_name":"Ivec, Alexis","last_name":"Ivec","first_name":"Alexis","id":"1d144691-e8be-11ed-9b33-bdd3077fad4c"},{"last_name":"Bock","first_name":"Christoph","full_name":"Bock, Christoph"},{"full_name":"Shigemoto, Ryuichi","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto"},{"orcid":"0000-0003-2279-1061","id":"37B36620-F248-11E8-B48F-1D18A9856A87","last_name":"Hippenmeyer","first_name":"Simon","full_name":"Hippenmeyer, Simon"}],"volume":112,"date_created":"2023-04-27T09:41:48Z","date_updated":"2024-03-05T09:43:02Z","file_date_updated":"2024-02-06T13:56:15Z","citation":{"ama":"Cheung GT, Pauler F, Koppensteiner P, et al. Multipotent progenitors instruct ontogeny of the superior colliculus. Neuron. 2024;112(2):230-246.e11. doi:10.1016/j.neuron.2023.11.009","ista":"Cheung GT, Pauler F, Koppensteiner P, Krausgruber T, Streicher C, Schrammel M, Özgen NY, Ivec A, Bock C, Shigemoto R, Hippenmeyer S. 2024. Multipotent progenitors instruct ontogeny of the superior colliculus. Neuron. 112(2), 230–246.e11.","ieee":"G. T. Cheung et al., “Multipotent progenitors instruct ontogeny of the superior colliculus,” Neuron, vol. 112, no. 2. Elsevier, p. 230–246.e11, 2024.","apa":"Cheung, G. T., Pauler, F., Koppensteiner, P., Krausgruber, T., Streicher, C., Schrammel, M., … Hippenmeyer, S. (2024). Multipotent progenitors instruct ontogeny of the superior colliculus. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2023.11.009","mla":"Cheung, Giselle T., et al. “Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus.” Neuron, vol. 112, no. 2, Elsevier, 2024, p. 230–246.e11, doi:10.1016/j.neuron.2023.11.009.","short":"G.T. Cheung, F. Pauler, P. Koppensteiner, T. Krausgruber, C. Streicher, M. Schrammel, N.Y. Özgen, A. Ivec, C. Bock, R. Shigemoto, S. Hippenmeyer, Neuron 112 (2024) 230–246.e11.","chicago":"Cheung, Giselle T, Florian Pauler, Peter Koppensteiner, Thomas Krausgruber, Carmen Streicher, Martin Schrammel, Natalie Y Özgen, et al. “Multipotent Progenitors Instruct Ontogeny of the Superior Colliculus.” Neuron. Elsevier, 2024. https://doi.org/10.1016/j.neuron.2023.11.009."},"publication":"Neuron","page":"230-246.e11","article_type":"original","date_published":"2024-01-17T00:00:00Z","scopus_import":"1","article_processing_charge":"Yes (via OA deal)","has_accepted_license":"1","day":"17","_id":"12875","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":" 112","status":"public","title":"Multipotent progenitors instruct ontogeny of the superior colliculus","ddc":["570"],"file":[{"relation":"main_file","file_id":"14944","date_updated":"2024-02-06T13:56:15Z","date_created":"2024-02-06T13:56:15Z","checksum":"32b3788f7085cf44a84108d8faaff3ce","success":1,"file_name":"2024_Neuron_Cheung.pdf","access_level":"open_access","file_size":5942467,"content_type":"application/pdf","creator":"dernst"}],"oa_version":"Published Version","type":"journal_article","issue":"2","abstract":[{"lang":"eng","text":"The superior colliculus (SC) in the mammalian midbrain is essential for multisensory integration and is composed of a rich diversity of excitatory and inhibitory neurons and glia. However, the developmental principles directing the generation of SC cell-type diversity are not understood. Here, we pursued systematic cell lineage tracing in silico and in vivo, preserving full spatial information, using genetic mosaic analysis with double markers (MADM)-based clonal analysis with single-cell sequencing (MADM-CloneSeq). The analysis of clonally related cell lineages revealed that radial glial progenitors (RGPs) in SC are exceptionally multipotent. Individual resident RGPs have the capacity to produce all excitatory and inhibitory SC neuron types, even at the stage of terminal division. While individual clonal units show no pre-defined cellular composition, the establishment of appropriate relative proportions of distinct neuronal types occurs in a PTEN-dependent manner. Collectively, our findings provide an inaugural framework at the single-RGP/-cell level of the mammalian SC ontogeny."}]},{"publication_identifier":{"issn":["0027-8424"],"eissn":["1091-6490"]},"month":"02","oa":1,"tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png"},"external_id":{"pmid":["38346189"]},"project":[{"grant_number":"694539","_id":"25CA28EA-B435-11E9-9278-68D0E5697425","name":"In situ analysis of single channel subunit composition in neurons: physiological implication in synaptic plasticity and behaviour","call_identifier":"H2020"},{"grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","name":"International IST Doctoral Program","call_identifier":"H2020"}],"quality_controlled":"1","doi":"10.1073/pnas.2301449121","language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"M-Shop"},{"_id":"PreCl"},{"_id":"EM-Fac"}],"article_number":"e2301449121","ec_funded":1,"file_date_updated":"2024-03-12T13:42:42Z","pmid":1,"year":"2024","acknowledgement":"We thank Erwin Neher and Ipe Ninan for critical comments on the manuscript. This project has received funding from the European Research Council (ERC) and European Commission, under the European Union’s Horizon 2020 research and innovation program (ERC grant agreement no. 694539 to R.S. and the Marie Skłodowska-Curie grant agreement no. 665385 to C.Ö.). This study was supported by the Cooperative Study Program of Center for Animal Resources and Collaborative Study of NINS. We thank Kohgaku Eguchi for statistical analysis, Yu Kasugai for additional EM imaging, Robert Beattie for the design of the slice recovery chamber for Flash and Freeze experiments, Todor Asenov from the ISTA machine shop for custom part preparations for high-pressure freezing, the ISTA preclinical facility for animal caretaking, and the ISTA EM facilities for technical support.","publisher":"Proceedings of the National Academy of Sciences","department":[{"_id":"RySh"},{"_id":"PeJo"}],"publication_status":"published","related_material":{"record":[{"id":"13173","status":"public","relation":"research_data"}],"link":[{"url":"https://ista.ac.at/en/news/neuronal-insights-flash-and-freeze-fracture/","description":"News on ISTA Website","relation":"press_release"}]},"author":[{"first_name":"Peter","last_name":"Koppensteiner","id":"3B8B25A8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3509-1948","full_name":"Koppensteiner, Peter"},{"full_name":"Bhandari, Pradeep","last_name":"Bhandari","first_name":"Pradeep","orcid":"0000-0003-0863-4481","id":"45EDD1BC-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Önal, Hüseyin C","last_name":"Önal","first_name":"Hüseyin C","orcid":"0000-0002-2771-2011","id":"4659D740-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Borges Merjane","first_name":"Carolina","orcid":"0000-0003-0005-401X","id":"4305C450-F248-11E8-B48F-1D18A9856A87","full_name":"Borges Merjane, Carolina"},{"full_name":"Le Monnier, Elodie","last_name":"Le Monnier","first_name":"Elodie","id":"3B59276A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Roy, Utsa","first_name":"Utsa","last_name":"Roy","id":"4d26cf11-5355-11ee-ae5a-eb05e255b9b2"},{"full_name":"Nakamura, Yukihiro","last_name":"Nakamura","first_name":"Yukihiro"},{"last_name":"Sadakata","first_name":"Tetsushi","full_name":"Sadakata, Tetsushi"},{"full_name":"Sanbo, Makoto","last_name":"Sanbo","first_name":"Makoto"},{"full_name":"Hirabayashi, Masumi","last_name":"Hirabayashi","first_name":"Masumi"},{"full_name":"Rhee, JeongSeop","first_name":"JeongSeop","last_name":"Rhee"},{"full_name":"Brose, Nils","last_name":"Brose","first_name":"Nils"},{"first_name":"Peter M","last_name":"Jonas","id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","full_name":"Jonas, Peter M"},{"full_name":"Shigemoto, Ryuichi","last_name":"Shigemoto","first_name":"Ryuichi","orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87"}],"volume":121,"date_updated":"2024-03-12T13:44:18Z","date_created":"2024-03-05T09:23:55Z","has_accepted_license":"1","article_processing_charge":"Yes (in subscription journal)","day":"20","citation":{"chicago":"Koppensteiner, Peter, Pradeep Bhandari, Cihan Önal, Carolina Borges Merjane, Elodie Le Monnier, Utsa Roy, Yukihiro Nakamura, et al. “GABAB Receptors Induce Phasic Release from Medial Habenula Terminals through Activity-Dependent Recruitment of Release-Ready Vesicles.” Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences, 2024. https://doi.org/10.1073/pnas.2301449121.","short":"P. Koppensteiner, P. Bhandari, C. Önal, C. Borges Merjane, E. Le Monnier, U. Roy, Y. Nakamura, T. Sadakata, M. Sanbo, M. Hirabayashi, J. Rhee, N. Brose, P.M. Jonas, R. Shigemoto, Proceedings of the National Academy of Sciences 121 (2024).","mla":"Koppensteiner, Peter, et al. “GABAB Receptors Induce Phasic Release from Medial Habenula Terminals through Activity-Dependent Recruitment of Release-Ready Vesicles.” Proceedings of the National Academy of Sciences, vol. 121, no. 8, e2301449121, Proceedings of the National Academy of Sciences, 2024, doi:10.1073/pnas.2301449121.","apa":"Koppensteiner, P., Bhandari, P., Önal, C., Borges Merjane, C., Le Monnier, E., Roy, U., … Shigemoto, R. (2024). GABAB receptors induce phasic release from medial habenula terminals through activity-dependent recruitment of release-ready vesicles. Proceedings of the National Academy of Sciences. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.2301449121","ieee":"P. Koppensteiner et al., “GABAB receptors induce phasic release from medial habenula terminals through activity-dependent recruitment of release-ready vesicles,” Proceedings of the National Academy of Sciences, vol. 121, no. 8. Proceedings of the National Academy of Sciences, 2024.","ista":"Koppensteiner P, Bhandari P, Önal C, Borges Merjane C, Le Monnier E, Roy U, Nakamura Y, Sadakata T, Sanbo M, Hirabayashi M, Rhee J, Brose N, Jonas PM, Shigemoto R. 2024. GABAB receptors induce phasic release from medial habenula terminals through activity-dependent recruitment of release-ready vesicles. Proceedings of the National Academy of Sciences. 121(8), e2301449121.","ama":"Koppensteiner P, Bhandari P, Önal C, et al. GABAB receptors induce phasic release from medial habenula terminals through activity-dependent recruitment of release-ready vesicles. Proceedings of the National Academy of Sciences. 2024;121(8). doi:10.1073/pnas.2301449121"},"publication":"Proceedings of the National Academy of Sciences","article_type":"original","date_published":"2024-02-20T00:00:00Z","type":"journal_article","issue":"8","abstract":[{"text":"GABAB receptor (GBR) activation inhibits neurotransmitter release in axon terminals in the brain, except in medial habenula (MHb) terminals, which show robust potentiation. However, mechanisms underlying this enigmatic potentiation remain elusive. Here, we report that GBR activation on MHb terminals induces an activity-dependent transition from a facilitating, tonic to a depressing, phasic neurotransmitter release mode. This transition is accompanied by a 4.1-fold increase in readily releasable vesicle pool (RRP) size and a 3.5-fold increase of docked synaptic vesicles (SVs) at the presynaptic active zone (AZ). Strikingly, the depressing phasic release exhibits looser coupling distance than the tonic release. Furthermore, the tonic and phasic release are selectively affected by deletion of synaptoporin (SPO) and Ca\r\n 2+\r\n -dependent activator protein for secretion 2 (CAPS2), respectively. SPO modulates augmentation, the short-term plasticity associated with tonic release, and CAPS2 retains the increased RRP for initial responses in phasic response trains. The cytosolic protein CAPS2 showed a SV-associated distribution similar to the vesicular transmembrane protein SPO, and they were colocalized in the same terminals. We developed the “Flash and Freeze-fracture” method, and revealed the release of SPO-associated vesicles in both tonic and phasic modes and activity-dependent recruitment of CAPS2 to the AZ during phasic release, which lasted several minutes. Overall, these results indicate that GBR activation translocates CAPS2 to the AZ along with the fusion of CAPS2-associated SVs, contributing to persistency of the RRP increase. Thus, we identified structural and molecular mechanisms underlying tonic and phasic neurotransmitter release and their transition by GBR activation in MHb terminals.","lang":"eng"}],"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"15084","intvolume":" 121","status":"public","title":"GABAB receptors induce phasic release from medial habenula terminals through activity-dependent recruitment of release-ready vesicles","ddc":["570"],"oa_version":"Published Version","file":[{"file_id":"15110","relation":"main_file","date_created":"2024-03-12T13:42:42Z","date_updated":"2024-03-12T13:42:42Z","success":1,"checksum":"b25b2a057c266ff317a48b0d54d6fc8a","file_name":"2024_PNAS_Koppensteiner.pdf","access_level":"open_access","creator":"dernst","file_size":13648221,"content_type":"application/pdf"}]},{"date_published":"2024-01-11T00:00:00Z","article_type":"original","citation":{"apa":"Chen, J., Kaufmann, W., Chen, C., Arai, itaru, Kim, O., Shigemoto, R., & Jonas, P. M. (n.d.). Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse. Neuron. Elsevier. https://doi.org/10.1016/j.neuron.2023.12.002","ieee":"J. Chen et al., “Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse,” Neuron. Elsevier.","ista":"Chen J, Kaufmann W, Chen C, Arai itaru, Kim O, Shigemoto R, Jonas PM. Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse. Neuron.","ama":"Chen J, Kaufmann W, Chen C, et al. Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse. Neuron. doi:10.1016/j.neuron.2023.12.002","chicago":"Chen, JingJing, Walter Kaufmann, Chong Chen, itaru Arai, Olena Kim, Ryuichi Shigemoto, and Peter M Jonas. “Developmental Transformation of Ca2+ Channel-Vesicle Nanotopography at a Central GABAergic Synapse.” Neuron. Elsevier, n.d. https://doi.org/10.1016/j.neuron.2023.12.002.","short":"J. Chen, W. Kaufmann, C. Chen, itaru Arai, O. Kim, R. Shigemoto, P.M. Jonas, Neuron (n.d.).","mla":"Chen, JingJing, et al. “Developmental Transformation of Ca2+ Channel-Vesicle Nanotopography at a Central GABAergic Synapse.” Neuron, Elsevier, doi:10.1016/j.neuron.2023.12.002."},"publication":"Neuron","article_processing_charge":"No","day":"11","scopus_import":"1","oa_version":"None","status":"public","title":"Developmental transformation of Ca2+ channel-vesicle nanotopography at a central GABAergic synapse","_id":"14843","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"lang":"eng","text":"The coupling between Ca2+ channels and release sensors is a key factor defining the signaling properties of a synapse. However, the coupling nanotopography at many synapses remains unknown, and it is unclear how it changes during development. To address these questions, we examined coupling at the cerebellar inhibitory basket cell (BC)-Purkinje cell (PC) synapse. Biophysical analysis of transmission by paired recording and intracellular pipette perfusion revealed that the effects of exogenous Ca2+ chelators decreased during development, despite constant reliance of release on P/Q-type Ca2+ channels. Structural analysis by freeze-fracture replica labeling (FRL) and transmission electron microscopy (EM) indicated that presynaptic P/Q-type Ca2+ channels formed nanoclusters throughout development, whereas docked vesicles were only clustered at later developmental stages. Modeling suggested a developmental transformation from a more random to a more clustered coupling nanotopography. Thus, presynaptic signaling developmentally approaches a point-to-point configuration, optimizing speed, reliability, and energy efficiency of synaptic transmission."}],"type":"journal_article","language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"PreCl"},{"_id":"M-Shop"}],"doi":"10.1016/j.neuron.2023.12.002","project":[{"name":"Biophysics and circuit function of a giant cortical glumatergic synapse","call_identifier":"H2020","grant_number":"692692","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425"},{"_id":"25C5A090-B435-11E9-9278-68D0E5697425","grant_number":"Z00312","name":"The Wittgenstein Prize","call_identifier":"FWF"},{"name":"Mechanisms of GABA release in hippocampal circuits","grant_number":"P36232","_id":"bd88be38-d553-11ed-ba76-81d5a70a6ef5"},{"_id":"26B66A3E-B435-11E9-9278-68D0E5697425","grant_number":"25383","name":"Development of nanodomain coupling between Ca2+ channels and release sensors at a central inhibitory synapse"}],"quality_controlled":"1","external_id":{"pmid":["38215739"]},"publication_identifier":{"issn":["0896-6273"],"eissn":["1097-4199"]},"month":"01","date_created":"2024-01-21T23:00:56Z","date_updated":"2024-03-14T13:14:18Z","related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"15101"}],"link":[{"description":"News on ISTA Website","relation":"press_release","url":"https://ista.ac.at/en/news/synapses-brought-to-the-point/"}]},"author":[{"id":"2C4E65C8-F248-11E8-B48F-1D18A9856A87","last_name":"Chen","first_name":"JingJing","full_name":"Chen, JingJing"},{"orcid":"0000-0001-9735-5315","id":"3F99E422-F248-11E8-B48F-1D18A9856A87","last_name":"Kaufmann","first_name":"Walter","full_name":"Kaufmann, Walter"},{"first_name":"Chong","last_name":"Chen","id":"3DFD581A-F248-11E8-B48F-1D18A9856A87","full_name":"Chen, Chong"},{"full_name":"Arai, Itaru","last_name":"Arai","first_name":"Itaru","id":"32A73F6C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Kim","first_name":"Olena","id":"3F8ABDDA-F248-11E8-B48F-1D18A9856A87","full_name":"Kim, Olena"},{"first_name":"Ryuichi","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi"},{"full_name":"Jonas, Peter M","last_name":"Jonas","first_name":"Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"}],"publisher":"Elsevier","department":[{"_id":"PeJo"},{"_id":"EM-Fac"},{"_id":"RySh"}],"publication_status":"inpress","pmid":1,"acknowledgement":"We thank Drs. David DiGregorio and Erwin Neher for critically reading an earlier version of the manuscript, Ralf Schneggenburger for helpful discussions, Benjamin Suter and Katharina Lichter for support with image analysis, Chris Wojtan for advice on numerical solution of partial differential equations, Maria Reva for help with Ripley analysis, Alois Schlögl for programming, and Akari Hagiwara and Toshihisa Ohtsuka for anti-ELKS antibody. We are grateful to Florian Marr, Christina Altmutter, and Vanessa Zheden for excellent technical assistance and to Eleftheria Kralli-Beller for manuscript editing. This research was supported by the Scientific Services Units (SSUs) of ISTA (Electron Microscopy Facility, Preclinical Facility, and Machine Shop). The project received funding from the European Research Council (ERC) under the European Union’s Horizon 2020 research and innovation program (grant agreement no. 692692), the Fonds zur Förderung der Wissenschaftlichen Forschung (Z 312-B27, Wittgenstein award; P 36232-B), all to P.J., and a DOC fellowship of the Austrian Academy of Sciences to J.-J.C.","year":"2024","ec_funded":1},{"oa_version":"Published Version","file":[{"file_id":"12814","embargo":"2024-04-07","relation":"main_file","checksum":"35b5997d2b0acb461f9d33d073da0df5","date_updated":"2023-04-07T06:16:06Z","date_created":"2023-04-07T06:16:06Z","access_level":"closed","file_name":"Thesis_CatarinaAlcarva_final pdfA.pdf","embargo_to":"open_access","creator":"cchlebak","file_size":9881969,"content_type":"application/pdf"},{"relation":"source_file","file_id":"12815","date_created":"2023-04-07T06:17:11Z","date_updated":"2023-04-07T06:17:11Z","checksum":"81198f63c294890f6d58e8b29782efdc","file_name":"Thesis_CatarinaAlcarva_final_for printing.pdf","access_level":"closed","file_size":44201583,"content_type":"application/pdf","creator":"cchlebak"},{"access_level":"closed","file_name":"Thesis_CatarinaAlcarva_final.docx","content_type":"application/vnd.openxmlformats-officedocument.wordprocessingml.document","file_size":84731244,"creator":"cchlebak","relation":"source_file","file_id":"12816","checksum":"0317bf7f457bb585f99d453ffa69eb53","date_updated":"2023-04-07T06:18:05Z","date_created":"2023-04-07T06:18:05Z"}],"title":"Plasticity in the cerebellum: What molecular mechanisms are behind physiological learning","ddc":["570"],"status":"public","user_id":"8b945eb4-e2f2-11eb-945a-df72226e66a9","_id":"12809","abstract":[{"text":"Understanding the mechanisms of learning and memory formation has always been one of\r\nthe main goals in neuroscience. Already Pavlov (1927) in his early days has used his classic\r\nconditioning experiments to study the neural mechanisms governing behavioral adaptation.\r\nWhat was not known back then was that the part of the brain that is largely responsible for\r\nthis type of associative learning is the cerebellum.\r\nSince then, plenty of theories on cerebellar learning have emerged. Despite their differences,\r\none thing they all have in common is that learning relies on synaptic and intrinsic plasticity.\r\nThe goal of my PhD project was to unravel the molecular mechanisms underlying synaptic\r\nplasticity in two synapses that have been shown to be implicated in motor learning, in an\r\neffort to understand how learning and memory formation are processed in the cerebellum.\r\nOne of the earliest and most well-known cerebellar theories postulates that motor learning\r\nlargely depends on long-term depression at the parallel fiber-Purkinje cell (PC-PC) synapse.\r\nHowever, the discovery of other types of plasticity in the cerebellar circuitry, like long-term\r\npotentiation (LTP) at the PC-PC synapse, potentiation of molecular layer interneurons (MLIs),\r\nand plasticity transfer from the cortex to the cerebellar/ vestibular nuclei has increased the\r\npopularity of the idea that multiple sites of plasticity might be involved in learning.\r\nStill a lot remains unknown about the molecular mechanisms responsible for these types of\r\nplasticity and whether they occur during physiological learning.\r\nIn the first part of this thesis we have analyzed the variation and nanodistribution of voltagegated calcium channels (VGCCs) and α-amino-3-hydroxy-5-methyl-4-isoxazolepropionic acid\r\ntype glutamate receptors (AMPARs) on the parallel fiber-Purkinje cell synapse after vestibuloocular reflex phase reversal adaptation, a behavior that has been suggested to rely on PF-PC\r\nLTP. We have found that on the last day of adaptation there is no learning trace in form of\r\nVGCCs nor AMPARs variation at the PF-PC synapse, but instead a decrease in the number of\r\nPF-PC synapses. These data seem to support the view that learning is only stored in the\r\ncerebellar cortex in an initial learning phase, being transferred later to the vestibular nuclei.\r\nNext, we have studied the role of MLIs in motor learning using a relatively simple and well characterized behavioral paradigm – horizontal optokinetic reflex (HOKR) adaptation. We\r\nhave found behavior-induced MLI potentiation in form of release probability increase that\r\ncould be explained by the increase of VGCCs at the presynaptic side. Our results strengthen\r\nthe idea of distributed cerebellar plasticity contributing to learning and provide a novel\r\nmechanism for release probability increase. ","lang":"eng"}],"alternative_title":["ISTA Thesis"],"type":"dissertation","date_published":"2023-04-06T00:00:00Z","page":"115","citation":{"ista":"Alcarva C. 2023. Plasticity in the cerebellum: What molecular mechanisms are behind physiological learning. Institute of Science and Technology Austria.","apa":"Alcarva, C. (2023). Plasticity in the cerebellum: What molecular mechanisms are behind physiological learning. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:12809","ieee":"C. Alcarva, “Plasticity in the cerebellum: What molecular mechanisms are behind physiological learning,” Institute of Science and Technology Austria, 2023.","ama":"Alcarva C. Plasticity in the cerebellum: What molecular mechanisms are behind physiological learning. 2023. doi:10.15479/at:ista:12809","chicago":"Alcarva, Catarina. “Plasticity in the Cerebellum: What Molecular Mechanisms Are behind Physiological Learning.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/at:ista:12809.","mla":"Alcarva, Catarina. Plasticity in the Cerebellum: What Molecular Mechanisms Are behind Physiological Learning. Institute of Science and Technology Austria, 2023, doi:10.15479/at:ista:12809.","short":"C. Alcarva, Plasticity in the Cerebellum: What Molecular Mechanisms Are behind Physiological Learning, Institute of Science and Technology Austria, 2023."},"article_processing_charge":"No","has_accepted_license":"1","day":"06","date_created":"2023-04-06T07:54:09Z","date_updated":"2023-04-26T12:16:56Z","author":[{"id":"3A96634C-F248-11E8-B48F-1D18A9856A87","last_name":"Alcarva","first_name":"Catarina","full_name":"Alcarva, Catarina"}],"publisher":"Institute of Science and Technology Austria","department":[{"_id":"GradSch"},{"_id":"RySh"}],"publication_status":"published","year":"2023","file_date_updated":"2023-04-07T06:18:05Z","language":[{"iso":"eng"}],"supervisor":[{"full_name":"Shigemoto, Ryuichi","first_name":"Ryuichi","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444"}],"degree_awarded":"PhD","acknowledged_ssus":[{"_id":"EM-Fac"},{"_id":"Bio"},{"_id":"PreCl"}],"doi":"10.15479/at:ista:12809","project":[{"_id":"267DFB90-B435-11E9-9278-68D0E5697425","name":"Plasticity in the cerebellum: Which molecular mechanisms are behind physiological learning?"}],"publication_identifier":{"issn":["2663 - 337X"]},"month":"04"},{"file_date_updated":"2023-09-06T06:50:07Z","article_number":"5231","author":[{"last_name":"Vierra","first_name":"Nicholas C.","full_name":"Vierra, Nicholas C."},{"full_name":"Ribeiro-Silva, Luisa","last_name":"Ribeiro-Silva","first_name":"Luisa"},{"last_name":"Kirmiz","first_name":"Michael","full_name":"Kirmiz, Michael"},{"first_name":"Deborah","last_name":"Van Der List","full_name":"Van Der List, Deborah"},{"orcid":"0000-0003-0863-4481","id":"45EDD1BC-F248-11E8-B48F-1D18A9856A87","last_name":"Bhandari","first_name":"Pradeep","full_name":"Bhandari, Pradeep"},{"full_name":"Mack, Olivia A.","first_name":"Olivia A.","last_name":"Mack"},{"last_name":"Carroll","first_name":"James","full_name":"Carroll, James"},{"full_name":"Le Monnier, Elodie","first_name":"Elodie","last_name":"Le Monnier","id":"3B59276A-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Aicher, Sue A.","last_name":"Aicher","first_name":"Sue A."},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi"},{"full_name":"Trimmer, James S.","first_name":"James S.","last_name":"Trimmer"}],"volume":14,"date_updated":"2023-09-06T06:53:32Z","date_created":"2023-09-03T22:01:14Z","pmid":1,"acknowledgement":"We thank Kayla Templeton and Peter Turcanu for technical assistance, Michelle Salemi for assistance with LC-MS data acquisition and analysis, Dr. Belvin Gong for advice on monoclonal antibody generation, Drs. Maria Casas Prat and Eamonn Dickson for assistance with super-resolution TIRF microscopy, Dr. Oscar Cerda for assistance with the design of TAT-FFAT peptides, Dr. Fernando Santana for helpful discussions, and Dr. Jodi Nunnari for a careful reading of our manuscript. We also thank Dr. Alan Howe, Dr. Sohum Mehta, and Dr. Jin Zhang for providing plasmids used in this study. This project was funded by NIH Grants R01NS114210 and R21NS101648 (J.S.T.), and F32NS108519 (N.C.V.).","year":"2023","department":[{"_id":"RySh"}],"publisher":"Springer Nature","publication_status":"published","publication_identifier":{"eissn":["2041-1723"]},"month":"08","doi":"10.1038/s41467-023-40930-6","language":[{"iso":"eng"}],"oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"external_id":{"pmid":["37633939"]},"quality_controlled":"1","abstract":[{"text":"Junctions between the endoplasmic reticulum (ER) and the plasma membrane (PM) are specialized membrane contacts ubiquitous in eukaryotic cells. Concentration of intracellular signaling machinery near ER-PM junctions allows these domains to serve critical roles in lipid and Ca2+ signaling and homeostasis. Subcellular compartmentalization of protein kinase A (PKA) signaling also regulates essential cellular functions, however, no specific association between PKA and ER-PM junctional domains is known. Here, we show that in brain neurons type I PKA is directed to Kv2.1 channel-dependent ER-PM junctional domains via SPHKAP, a type I PKA-specific anchoring protein. SPHKAP association with type I PKA regulatory subunit RI and ER-resident VAP proteins results in the concentration of type I PKA between stacked ER cisternae associated with ER-PM junctions. This ER-associated PKA signalosome enables reciprocal regulation between PKA and Ca2+ signaling machinery to support Ca2+ influx and excitation-transcription coupling. These data reveal that neuronal ER-PM junctions support a receptor-independent form of PKA signaling driven by membrane depolarization and intracellular Ca2+, allowing conversion of information encoded in electrical signals into biochemical changes universally recognized throughout the cell.","lang":"eng"}],"type":"journal_article","oa_version":"Published Version","file":[{"file_name":"2023_NatureComm_Vierra.pdf","access_level":"open_access","creator":"dernst","file_size":9412549,"content_type":"application/pdf","file_id":"14270","relation":"main_file","date_created":"2023-09-06T06:50:07Z","date_updated":"2023-09-06T06:50:07Z","success":1,"checksum":"6ab8aab4e957f626a09a1c73db3388fb"}],"_id":"14253","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":" 14","title":"Neuronal ER-plasma membrane junctions couple excitation to Ca2+-activated PKA signaling","ddc":["570"],"status":"public","article_processing_charge":"Yes","has_accepted_license":"1","day":"26","scopus_import":"1","date_published":"2023-08-26T00:00:00Z","citation":{"chicago":"Vierra, Nicholas C., Luisa Ribeiro-Silva, Michael Kirmiz, Deborah Van Der List, Pradeep Bhandari, Olivia A. Mack, James Carroll, et al. “Neuronal ER-Plasma Membrane Junctions Couple Excitation to Ca2+-Activated PKA Signaling.” Nature Communications. Springer Nature, 2023. https://doi.org/10.1038/s41467-023-40930-6.","mla":"Vierra, Nicholas C., et al. “Neuronal ER-Plasma Membrane Junctions Couple Excitation to Ca2+-Activated PKA Signaling.” Nature Communications, vol. 14, 5231, Springer Nature, 2023, doi:10.1038/s41467-023-40930-6.","short":"N.C. Vierra, L. Ribeiro-Silva, M. Kirmiz, D. Van Der List, P. Bhandari, O.A. Mack, J. Carroll, E. Le Monnier, S.A. Aicher, R. Shigemoto, J.S. Trimmer, Nature Communications 14 (2023).","ista":"Vierra NC, Ribeiro-Silva L, Kirmiz M, Van Der List D, Bhandari P, Mack OA, Carroll J, Le Monnier E, Aicher SA, Shigemoto R, Trimmer JS. 2023. Neuronal ER-plasma membrane junctions couple excitation to Ca2+-activated PKA signaling. Nature Communications. 14, 5231.","apa":"Vierra, N. C., Ribeiro-Silva, L., Kirmiz, M., Van Der List, D., Bhandari, P., Mack, O. A., … Trimmer, J. S. (2023). Neuronal ER-plasma membrane junctions couple excitation to Ca2+-activated PKA signaling. Nature Communications. Springer Nature. https://doi.org/10.1038/s41467-023-40930-6","ieee":"N. C. Vierra et al., “Neuronal ER-plasma membrane junctions couple excitation to Ca2+-activated PKA signaling,” Nature Communications, vol. 14. Springer Nature, 2023.","ama":"Vierra NC, Ribeiro-Silva L, Kirmiz M, et al. Neuronal ER-plasma membrane junctions couple excitation to Ca2+-activated PKA signaling. Nature Communications. 2023;14. doi:10.1038/s41467-023-40930-6"},"publication":"Nature Communications","article_type":"original"},{"abstract":[{"lang":"eng","text":"Phosphatidylinositol-4,5-bisphosphate (PI(4,5)P2) plays an essential role in neuronal activities through interaction with various proteins involved in signaling at membranes. However, the distribution pattern of PI(4,5)P2 and the association with these proteins on the neuronal cell membranes remain elusive. In this study, we established a method for visualizing PI(4,5)P2 by SDS-digested freeze-fracture replica labeling (SDS-FRL) to investigate the quantitative nanoscale distribution of PI(4,5)P2 in cryo-fixed brain. We demonstrate that PI(4,5)P2 forms tiny clusters with a mean size of ∼1000 nm2 rather than randomly distributed in cerebellar neuronal membranes in male C57BL/6J mice. These clusters show preferential accumulation in specific membrane compartments of different cell types, in particular, in Purkinje cell (PC) spines and granule cell (GC) presynaptic active zones. Furthermore, we revealed extensive association of PI(4,5)P2 with CaV2.1 and GIRK3 across different membrane compartments, whereas its association with mGluR1α was compartment specific. These results suggest that our SDS-FRL method provides valuable insights into the physiological functions of PI(4,5)P2 in neurons."}],"issue":"23","type":"journal_article","oa_version":"Published Version","file":[{"creator":"alisjak","file_size":7794425,"content_type":"application/pdf","access_level":"open_access","file_name":"2023_JN_Eguchi.pdf","success":1,"checksum":"70b2141870e0bf1c94fd343e18fdbc32","date_updated":"2023-07-10T09:04:58Z","date_created":"2023-07-10T09:04:58Z","file_id":"13205","relation":"main_file"}],"_id":"13202","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","ddc":["570"],"title":"Nanoscale phosphoinositide distribution on cell membranes of mouse cerebellar neurons","intvolume":" 43","day":"07","article_processing_charge":"No","has_accepted_license":"1","scopus_import":"1","date_published":"2023-06-07T00:00:00Z","publication":"The Journal of Neuroscience","citation":{"chicago":"Eguchi, Kohgaku, Elodie Le Monnier, and Ryuichi Shigemoto. “Nanoscale Phosphoinositide Distribution on Cell Membranes of Mouse Cerebellar Neurons.” The Journal of Neuroscience. Society for Neuroscience, 2023. https://doi.org/10.1523/JNEUROSCI.1514-22.2023.","mla":"Eguchi, Kohgaku, et al. “Nanoscale Phosphoinositide Distribution on Cell Membranes of Mouse Cerebellar Neurons.” The Journal of Neuroscience, vol. 43, no. 23, Society for Neuroscience, 2023, pp. 4197–216, doi:10.1523/JNEUROSCI.1514-22.2023.","short":"K. Eguchi, E. Le Monnier, R. Shigemoto, The Journal of Neuroscience 43 (2023) 4197–4216.","ista":"Eguchi K, Le Monnier E, Shigemoto R. 2023. Nanoscale phosphoinositide distribution on cell membranes of mouse cerebellar neurons. The Journal of Neuroscience. 43(23), 4197–4216.","apa":"Eguchi, K., Le Monnier, E., & Shigemoto, R. (2023). Nanoscale phosphoinositide distribution on cell membranes of mouse cerebellar neurons. The Journal of Neuroscience. Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.1514-22.2023","ieee":"K. Eguchi, E. Le Monnier, and R. Shigemoto, “Nanoscale phosphoinositide distribution on cell membranes of mouse cerebellar neurons,” The Journal of Neuroscience, vol. 43, no. 23. Society for Neuroscience, pp. 4197–4216, 2023.","ama":"Eguchi K, Le Monnier E, Shigemoto R. Nanoscale phosphoinositide distribution on cell membranes of mouse cerebellar neurons. The Journal of Neuroscience. 2023;43(23):4197-4216. doi:10.1523/JNEUROSCI.1514-22.2023"},"article_type":"original","page":"4197-4216","file_date_updated":"2023-07-10T09:04:58Z","ec_funded":1,"author":[{"full_name":"Eguchi, Kohgaku","id":"2B7846DC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6170-2546","first_name":"Kohgaku","last_name":"Eguchi"},{"id":"3B59276A-F248-11E8-B48F-1D18A9856A87","last_name":"Le Monnier","first_name":"Elodie","full_name":"Le Monnier, Elodie"},{"id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","first_name":"Ryuichi","last_name":"Shigemoto","full_name":"Shigemoto, Ryuichi"}],"date_created":"2023-07-09T22:01:12Z","date_updated":"2023-10-18T07:12:47Z","volume":43,"acknowledgement":"This work was supported by The Institute of Science and Technology (IST) Austria, the European Union's Horizon 2020 Research and Innovation Program under the Marie Skłodowska-Curie Grant Agreement No. 793482 (to K.E.) and by the European Research Council (ERC) Grant Agreement No. 694539 (to R.S.). We thank Nicoleta Condruz (IST Austria, Klosterneuburg, Austria) for technical assistance with sample preparation, the Electron Microscopy Facility of IST Austria (Klosterneuburg, Austria) for technical support with EM works, Natalia Baranova (University of Vienna, Vienna, Austria) and Martin Loose (IST Austria, Klosterneuburg, Austria) for advice on liposome preparation, and Yugo Fukazawa (University of Fukui, Fukui, Japan) for comments.","year":"2023","pmid":1,"publication_status":"published","publisher":"Society for Neuroscience","department":[{"_id":"RySh"}],"month":"06","publication_identifier":{"eissn":["1529-2401"],"issn":["0270-6474"]},"doi":"10.1523/JNEUROSCI.1514-22.2023","acknowledged_ssus":[{"_id":"EM-Fac"}],"language":[{"iso":"eng"}],"external_id":{"pmid":["37160366"],"isi":["001020132100005"]},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"isi":1,"quality_controlled":"1","project":[{"grant_number":"793482","_id":"2659CC84-B435-11E9-9278-68D0E5697425","name":"Ultrastructural analysis of phosphoinositides in nerve terminals: distribution, dynamics and physiological roles in synaptic transmission","call_identifier":"H2020"},{"call_identifier":"H2020","name":"In situ analysis of single channel subunit composition in neurons: physiological implication in synaptic plasticity and behaviour","_id":"25CA28EA-B435-11E9-9278-68D0E5697425","grant_number":"694539"}]},{"citation":{"chicago":"Danzl, Johann G. “Research Data for the Publication ‘Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.’” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/AT:ISTA:13126.","short":"J.G. Danzl, (2023).","mla":"Danzl, Johann G. Research Data for the Publication “Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.” Institute of Science and Technology Austria, 2023, doi:10.15479/AT:ISTA:13126.","ieee":"J. G. Danzl, “Research data for the publication ‘Imaging brain tissue architecture across millimeter to nanometer scales.’” Institute of Science and Technology Austria, 2023.","apa":"Danzl, J. G. (2023). Research data for the publication “Imaging brain tissue architecture across millimeter to nanometer scales.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:13126","ista":"Danzl JG. 2023. Research data for the publication ‘Imaging brain tissue architecture across millimeter to nanometer scales’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:13126.","ama":"Danzl JG. Research data for the publication “Imaging brain tissue architecture across millimeter to nanometer scales.” 2023. doi:10.15479/AT:ISTA:13126"},"date_published":"2023-08-04T00:00:00Z","article_processing_charge":"No","has_accepted_license":"1","day":"04","_id":"13126","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","title":"Research data for the publication \"Imaging brain tissue architecture across millimeter to nanometer scales\"","ddc":["610"],"status":"public","file":[{"access_level":"open_access","file_name":"Readme_Michalska_2023.txt","content_type":"text/plain","file_size":541,"creator":"jdanzl","relation":"main_file","file_id":"13961","checksum":"6f18ce9b89b47ce5abeb379869ff5c49","success":1,"date_created":"2023-08-04T13:19:47Z","date_updated":"2023-08-04T13:19:47Z"},{"content_type":"image/tiff","file_size":64582744,"creator":"jdanzl","access_level":"open_access","file_name":"Fig1_b_top-left.tif","checksum":"2098e8c5285c5e86cb69075e1b5dcf39","success":1,"date_created":"2023-08-03T11:29:29Z","date_updated":"2023-08-03T11:29:29Z","relation":"main_file","file_id":"13482"},{"creator":"jdanzl","file_size":1442113,"content_type":"image/tiff","access_level":"open_access","file_name":"Fig1_b_top-right.tif","success":1,"checksum":"9affab3dacf847096cc8e8d5ff99467e","date_updated":"2023-08-03T11:29:28Z","date_created":"2023-08-03T11:29:28Z","file_id":"13483","relation":"main_file"},{"creator":"jdanzl","content_type":"image/tiff","file_size":40078276,"file_name":"Fig1_c_1.tif","access_level":"open_access","date_created":"2023-08-03T11:29:29Z","date_updated":"2023-08-03T11:29:29Z","success":1,"checksum":"d7fec0296123a17f6bcdbfee17411424","file_id":"13484","relation":"main_file"},{"relation":"main_file","file_id":"13485","date_updated":"2023-08-03T11:29:29Z","date_created":"2023-08-03T11:29:29Z","checksum":"5195a180c4f26a7adc994bad0b3c53c7","success":1,"file_name":"Fig1_c_2.tif","access_level":"open_access","file_size":7984315,"content_type":"image/tiff","creator":"jdanzl"},{"file_size":8693320,"content_type":"image/tiff","creator":"jdanzl","file_name":"Fig1_c_3.tif","access_level":"open_access","date_created":"2023-08-03T11:29:29Z","date_updated":"2023-08-03T11:29:29Z","checksum":"df1105d8f41ebd5373cacc597ffa91f3","success":1,"relation":"main_file","file_id":"13486"},{"relation":"main_file","file_id":"13487","checksum":"00edbb0c9f42032c830d2291ec55c4c0","success":1,"date_updated":"2023-08-03T11:29:30Z","date_created":"2023-08-03T11:29:30Z","access_level":"open_access","file_name":"Fig1_c_4.tif","file_size":6003063,"content_type":"image/tiff","creator":"jdanzl"},{"content_type":"image/tiff","file_size":24003063,"creator":"jdanzl","file_name":"Fig1_d.tif","access_level":"open_access","date_created":"2023-08-03T11:29:30Z","date_updated":"2023-08-03T11:29:30Z","checksum":"a58399e98ec4b6506a5dae13e387f391","success":1,"relation":"main_file","file_id":"13488"},{"date_updated":"2023-08-03T11:29:30Z","date_created":"2023-08-03T11:29:30Z","success":1,"checksum":"699df4bc104df14607359678963b3d2d","file_id":"13489","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":18063,"file_name":"Fig1_e_zoom.tif","access_level":"open_access"},{"file_id":"13490","relation":"main_file","success":1,"checksum":"ea7b1278da490d221fc7698fd6bc39a4","date_created":"2023-08-03T11:29:30Z","date_updated":"2023-08-03T11:29:30Z","access_level":"open_access","file_name":"Fig1_e.tif","creator":"jdanzl","file_size":186813,"content_type":"image/tiff"},{"creator":"jdanzl","file_size":17494,"content_type":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","access_level":"open_access","file_name":"Fig1_f.xlsx","success":1,"checksum":"37b05ef3a36b9f6bf4ec46199230874a","date_created":"2023-08-03T11:29:30Z","date_updated":"2023-08-03T11:29:30Z","file_id":"13491","relation":"main_file"},{"file_size":816786862,"content_type":"image/tiff","creator":"jdanzl","file_name":"Fig2_a_1.tif","access_level":"open_access","date_created":"2023-08-03T11:40:43Z","date_updated":"2023-08-03T11:40:43Z","checksum":"872eb3dc1a94afb26947a365bfae581a","success":1,"relation":"main_file","file_id":"13492"},{"date_created":"2023-08-03T11:40:13Z","date_updated":"2023-08-03T11:40:13Z","checksum":"cab6f72d7d546a81c105c229747949ef","success":1,"relation":"main_file","file_id":"13493","file_size":8654692,"content_type":"image/tiff","creator":"jdanzl","file_name":"Fig2_a_2.tif","access_level":"open_access"},{"relation":"main_file","file_id":"13494","date_created":"2023-08-03T11:40:14Z","date_updated":"2023-08-03T11:40:14Z","checksum":"c85bc3ffe7f6bdf16a81290761ed6253","success":1,"file_name":"Fig2_a_3.tif","access_level":"open_access","content_type":"image/tiff","file_size":8654692,"creator":"jdanzl"},{"success":1,"checksum":"5a3fd5484e566c34e210a4acb2b97791","date_updated":"2023-08-03T11:40:24Z","date_created":"2023-08-03T11:40:24Z","file_id":"13495","relation":"main_file","creator":"jdanzl","file_size":272262438,"content_type":"image/tiff","access_level":"open_access","file_name":"Fig2_a_4.tif"},{"file_id":"13496","relation":"main_file","success":1,"checksum":"ae5cbacf56e3fdf934a6d6fd489f5fe0","date_created":"2023-08-03T11:40:37Z","date_updated":"2023-08-03T11:40:37Z","access_level":"open_access","file_name":"Fig2_a_5.tif","creator":"jdanzl","file_size":272262438,"content_type":"image/tiff"},{"date_created":"2023-08-03T11:40:44Z","date_updated":"2023-08-03T11:40:44Z","success":1,"checksum":"e6da436b83bbe3a34138b52e5de49d69","file_id":"13497","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":204301228,"file_name":"Fig2_a_6.tif","access_level":"open_access"},{"relation":"main_file","file_id":"13498","date_created":"2023-08-03T11:40:49Z","date_updated":"2023-08-03T11:40:49Z","checksum":"855f0a0bcf5b3d7cc7d50561f2c8f625","success":1,"file_name":"Fig2_a_7-8.tif","access_level":"open_access","content_type":"image/tiff","file_size":68094350,"creator":"jdanzl"},{"creator":"jdanzl","content_type":"application/octet-stream","file_size":156,"file_name":"Fig2_a_roi.roi","access_level":"open_access","date_created":"2023-08-03T11:40:48Z","date_updated":"2023-08-03T11:40:48Z","success":1,"checksum":"ff709f9f8ebaa8cf50a4b2fca5ce9813","file_id":"13499","relation":"main_file"},{"file_id":"13500","relation":"main_file","success":1,"checksum":"ce9b774ff5163ebfa4e3fb162f4cfffe","date_created":"2023-08-03T11:41:37Z","date_updated":"2023-08-03T11:41:37Z","access_level":"open_access","file_name":"Fig2_c-i_1_n2v.tif","creator":"jdanzl","file_size":1036927887,"content_type":"image/tiff"},{"access_level":"open_access","file_name":"Fig2_c-i_1.tif","creator":"jdanzl","file_size":518519275,"content_type":"image/tiff","file_id":"13501","relation":"main_file","success":1,"checksum":"21f1bb8d2a00c88bdd6febe6285acc2a","date_updated":"2023-08-03T11:41:25Z","date_created":"2023-08-03T11:41:25Z"},{"file_name":"Fig2_c-i_3_n2v.tif","access_level":"open_access","content_type":"image/tiff","file_size":1444202302,"creator":"jdanzl","relation":"main_file","file_id":"13502","date_updated":"2023-08-03T11:42:48Z","date_created":"2023-08-03T11:42:48Z","checksum":"9af5b66b74c2ff4b2b99b0d94f2864e6","success":1},{"creator":"jdanzl","content_type":"image/tiff","file_size":1075338708,"file_name":"Fig2_c-i_3.tif","access_level":"open_access","date_updated":"2023-08-03T11:42:57Z","date_created":"2023-08-03T11:42:57Z","success":1,"checksum":"c83261e88821747b301197314d92f2b2","file_id":"13503","relation":"main_file"},{"file_id":"13504","relation":"main_file","success":1,"checksum":"5d1278ba4b7e085c0c186ea49fce535b","date_updated":"2023-08-03T11:44:05Z","date_created":"2023-08-03T11:44:05Z","access_level":"open_access","file_name":"Fig2_c-i_2_n2v.tif","creator":"jdanzl","content_type":"image/tiff","file_size":851145493},{"file_name":"Fig2_c-i_2.tif","access_level":"open_access","file_size":432099834,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13505","date_created":"2023-08-03T11:43:47Z","date_updated":"2023-08-03T11:43:47Z","checksum":"5aaf1eba65582cf437ff3ce753eba4d7","success":1},{"access_level":"open_access","file_name":"Fig2_h_n2v.tif","file_size":1036927887,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13506","checksum":"ce9b774ff5163ebfa4e3fb162f4cfffe","success":1,"date_updated":"2023-08-03T11:44:41Z","date_created":"2023-08-03T11:44:41Z"},{"creator":"jdanzl","file_size":518519275,"content_type":"image/tiff","access_level":"open_access","file_name":"Fig2_h.tif","success":1,"checksum":"21f1bb8d2a00c88bdd6febe6285acc2a","date_updated":"2023-08-03T11:44:36Z","date_created":"2023-08-03T11:44:36Z","file_id":"13507","relation":"main_file"},{"file_id":"13508","relation":"main_file","success":1,"checksum":"b37f25a90ef42fa4358649fdd6b41f35","date_updated":"2023-08-03T11:44:40Z","date_created":"2023-08-03T11:44:40Z","access_level":"open_access","file_name":"Fig2_j_1.tif","creator":"jdanzl","content_type":"image/tiff","file_size":19287397},{"access_level":"open_access","file_name":"Fig2_j_2.tif","file_size":617552,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13509","checksum":"50f0969c6c2c1209ff776bec4861030a","success":1,"date_updated":"2023-08-03T11:44:41Z","date_created":"2023-08-03T11:44:41Z"},{"content_type":"image/tiff","file_size":19287392,"creator":"jdanzl","access_level":"open_access","file_name":"Fig2_j_3.tif","checksum":"2a8cc93471378ac4c3b640e4318d89eb","success":1,"date_updated":"2023-08-03T11:44:41Z","date_created":"2023-08-03T11:44:41Z","relation":"main_file","file_id":"13510"},{"file_size":617552,"content_type":"image/tiff","creator":"jdanzl","file_name":"Fig2_j_4.tif","access_level":"open_access","date_created":"2023-08-03T11:44:42Z","date_updated":"2023-08-03T11:44:42Z","checksum":"b90965d20133fea73c99050c32eb7695","success":1,"relation":"main_file","file_id":"13511"},{"creator":"jdanzl","content_type":"image/tiff","file_size":19287339,"access_level":"open_access","file_name":"Fig2_j_coCATS_N2V.tif","success":1,"checksum":"568a1e0efaa62527b51e66a7aabfd05c","date_updated":"2023-08-03T11:44:43Z","date_created":"2023-08-03T11:44:43Z","file_id":"13512","relation":"main_file"},{"relation":"main_file","file_id":"13513","date_created":"2023-08-03T11:44:44Z","date_updated":"2023-08-03T11:44:44Z","checksum":"c70447cebe073dd78e0ac34ecc36ad85","success":1,"file_name":"Fig2_j_roi.roi","access_level":"open_access","file_size":148,"content_type":"application/octet-stream","creator":"jdanzl"},{"file_id":"13514","relation":"main_file","success":1,"checksum":"505252cc4b443b76c2e41ecf5879a542","date_updated":"2023-08-03T11:44:52Z","date_created":"2023-08-03T11:44:52Z","access_level":"open_access","file_name":"Fig3_a_n2v.tif","creator":"jdanzl","file_size":316842690,"content_type":"image/tiff"},{"creator":"jdanzl","content_type":"image/tiff","file_size":172839057,"access_level":"open_access","file_name":"Fig3_a.tif","success":1,"checksum":"35463183611e8ee4fba2025772c40eb2","date_updated":"2023-08-03T11:45:01Z","date_created":"2023-08-03T11:45:01Z","file_id":"13515","relation":"main_file"},{"creator":"jdanzl","content_type":"image/tiff","file_size":309407894,"file_name":"Fig3_g_n2v.tif","access_level":"open_access","date_created":"2023-08-03T11:45:05Z","date_updated":"2023-08-03T11:45:05Z","success":1,"checksum":"e0469102a87332b46904b4ba35b8fb2f","file_id":"13516","relation":"main_file"},{"access_level":"open_access","file_name":"Fig4_a_MIP.tif","content_type":"image/tiff","file_size":11327792,"creator":"jdanzl","relation":"main_file","file_id":"13517","checksum":"854c8fe02acd920f8e8f6a3173458e86","success":1,"date_created":"2023-08-03T11:51:15Z","date_updated":"2023-08-03T11:51:15Z"},{"creator":"jdanzl","content_type":"image/tiff","file_size":106696700,"file_name":"Fig4_c_dghilus_bouton2_n2v.tif","access_level":"open_access","date_updated":"2023-08-03T11:51:18Z","date_created":"2023-08-03T11:51:18Z","success":1,"checksum":"ab35811ffbe3f40733d0e054d9d6c4e6","file_id":"13518","relation":"main_file"},{"content_type":"image/tiff","file_size":53367287,"creator":"jdanzl","access_level":"open_access","file_name":"Fig4_c_dghilus_bouton2.tif","checksum":"e3b6410d68e42004ef3857967707aeb3","success":1,"date_updated":"2023-08-03T11:51:17Z","date_created":"2023-08-03T11:51:17Z","relation":"main_file","file_id":"13519"},{"content_type":"image/tiff","file_size":103816699,"creator":"jdanzl","file_name":"Fig4_c_dghilus_bouton5_n2v.tif","access_level":"open_access","date_updated":"2023-08-03T11:51:20Z","date_created":"2023-08-03T11:51:20Z","checksum":"9ef0e3f3ec6f0b7b2666e3a0d7e6f355","success":1,"relation":"main_file","file_id":"13520"},{"success":1,"checksum":"d5d846a4edaf0168ca6cc53d8cc39dde","date_created":"2023-08-03T11:51:21Z","date_updated":"2023-08-03T11:51:21Z","file_id":"13521","relation":"main_file","creator":"jdanzl","file_size":51927287,"content_type":"image/tiff","access_level":"open_access","file_name":"Fig4_c_dghilus_bouton5.tif"},{"date_updated":"2023-08-03T11:51:24Z","date_created":"2023-08-03T11:51:24Z","success":1,"checksum":"690a87182441c9742da2550189641e5a","file_id":"13522","relation":"main_file","creator":"jdanzl","file_size":76391971,"content_type":"image/tiff","file_name":"Fig4_c_stratum_bouton11_n2v.tif","access_level":"open_access"},{"success":1,"checksum":"4dc575424729c5ba181bd9a3962d4781","date_created":"2023-08-03T11:51:23Z","date_updated":"2023-08-03T11:51:23Z","file_id":"13523","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":38217920,"access_level":"open_access","file_name":"Fig4_c_stratum_bouton11.tif"},{"file_id":"13524","relation":"main_file","date_updated":"2023-08-03T11:51:29Z","date_created":"2023-08-03T11:51:29Z","success":1,"checksum":"9fdd51636928f45e8e534cc5a37a48ff","file_name":"Fig4_c_stratum_bouton13_n2v.tif","access_level":"open_access","creator":"jdanzl","file_size":154149020,"content_type":"image/tiff"},{"relation":"main_file","file_id":"13525","checksum":"643169464252d67753ac6f8493668f34","success":1,"date_updated":"2023-08-03T11:51:28Z","date_created":"2023-08-03T11:51:28Z","access_level":"open_access","file_name":"Fig4_c_stratum_bouton13.tif","file_size":77099447,"content_type":"image/tiff","creator":"jdanzl"},{"date_updated":"2023-08-03T11:51:32Z","date_created":"2023-08-03T11:51:32Z","success":1,"checksum":"ab35811ffbe3f40733d0e054d9d6c4e6","file_id":"13526","relation":"main_file","creator":"jdanzl","file_size":106696700,"content_type":"image/tiff","file_name":"Fig4_d.tif","access_level":"open_access"},{"content_type":"image/tiff","file_size":154149020,"creator":"jdanzl","access_level":"open_access","file_name":"Fig4_e.tif","checksum":"9fdd51636928f45e8e534cc5a37a48ff","success":1,"date_created":"2023-08-03T11:51:35Z","date_updated":"2023-08-03T11:51:35Z","relation":"main_file","file_id":"13527"},{"creator":"jdanzl","content_type":"image/tiff","file_size":5986760,"file_name":"Fig4_f_1_top.tif","access_level":"open_access","date_updated":"2023-08-03T11:51:32Z","date_created":"2023-08-03T11:51:32Z","success":1,"checksum":"5380d0a98e97d7d8462b38bd0a96644c","file_id":"13528","relation":"main_file"},{"success":1,"checksum":"7d1309e806eb31588ebafcf40388e13f","date_updated":"2023-08-03T11:51:33Z","date_created":"2023-08-03T11:51:33Z","file_id":"13529","relation":"main_file","creator":"jdanzl","file_size":6001178,"content_type":"image/tiff","access_level":"open_access","file_name":"Fig4_f_2_top.tif"},{"file_id":"13530","relation":"main_file","date_updated":"2023-08-03T11:51:33Z","date_created":"2023-08-03T11:51:33Z","success":1,"checksum":"a71c80207655d508cbc7626bc144d7a1","file_name":"Fig4_f_3_top.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":6023318},{"date_created":"2023-08-03T11:51:34Z","date_updated":"2023-08-03T11:51:34Z","success":1,"checksum":"5d76b2ad7d7acbb1afa27cf52194b1cb","file_id":"13531","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":6038186,"file_name":"Fig4_f_4_top.tif","access_level":"open_access"},{"date_created":"2023-08-03T11:51:34Z","date_updated":"2023-08-03T11:51:34Z","success":1,"checksum":"9cee6b3387bd880843f2c6cdfa0d4a8d","file_id":"13532","relation":"main_file","creator":"jdanzl","file_size":2324158,"content_type":"image/tiff","file_name":"Fig4_f_5_top.tif","access_level":"open_access"},{"file_size":1150264,"content_type":"image/png","creator":"jdanzl","access_level":"open_access","file_name":"Fig4_f_1_bottom.png","checksum":"a48fc9e1bb2710cf28466ae6d2a20c19","success":1,"date_updated":"2023-08-03T11:51:34Z","date_created":"2023-08-03T11:51:34Z","relation":"main_file","file_id":"13533"},{"relation":"main_file","file_id":"13534","checksum":"ff47ca30f814e17561974b73b0913a1a","success":1,"date_created":"2023-08-03T11:51:34Z","date_updated":"2023-08-03T11:51:34Z","access_level":"open_access","file_name":"Fig4_f_2_bottom.png","content_type":"image/png","file_size":1157424,"creator":"jdanzl"},{"content_type":"image/png","file_size":1152715,"creator":"jdanzl","file_name":"Fig4_f_3_bottom.png","access_level":"open_access","date_updated":"2023-08-03T11:51:34Z","date_created":"2023-08-03T11:51:34Z","checksum":"2ea3fb8d79cee8ae9de7ca31d003910f","success":1,"relation":"main_file","file_id":"13535"},{"checksum":"d25e5ecf2f0c3be7c20a7e25a7a334b8","success":1,"date_created":"2023-08-03T11:51:34Z","date_updated":"2023-08-03T11:51:34Z","relation":"main_file","file_id":"13536","content_type":"image/png","file_size":1105240,"creator":"jdanzl","access_level":"open_access","file_name":"Fig4_f_4_bottom.png"},{"creator":"jdanzl","content_type":"image/png","file_size":1228157,"access_level":"open_access","file_name":"Fig4_f_5_bottom.png","success":1,"checksum":"76535f569a57b967e378df89b7d2982a","date_updated":"2023-08-03T11:51:35Z","date_created":"2023-08-03T11:51:35Z","file_id":"13537","relation":"main_file"},{"checksum":"d46fefe73daa3ec08b847631e9de6828","success":1,"date_updated":"2023-08-03T11:53:52Z","date_created":"2023-08-03T11:53:52Z","relation":"main_file","file_id":"13538","file_size":91181184,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Fig5_a_1.tif"},{"file_name":"Fig5_a_2.tif","access_level":"open_access","file_size":176024124,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13539","date_updated":"2023-08-03T11:53:54Z","date_created":"2023-08-03T11:53:54Z","checksum":"354c0ba876a33672eca37cd61dac7073","success":1},{"file_id":"13540","relation":"main_file","success":1,"checksum":"d07925040ef0c3c51edbdca8cf3ec1fa","date_created":"2023-08-03T11:53:53Z","date_updated":"2023-08-03T11:53:53Z","access_level":"open_access","file_name":"Fig5_a_3.tif","creator":"jdanzl","content_type":"image/tiff","file_size":15812494},{"checksum":"7c34b19a1764e2f501f11dcabd442ce2","success":1,"date_updated":"2023-08-03T11:53:53Z","date_created":"2023-08-03T11:53:53Z","relation":"main_file","file_id":"13541","content_type":"image/tiff","file_size":11117689,"creator":"jdanzl","access_level":"open_access","file_name":"Fig5_a_4.tif"},{"access_level":"open_access","file_name":"Fig5_a_5.tif","content_type":"image/tiff","file_size":111665,"creator":"jdanzl","relation":"main_file","file_id":"13542","checksum":"c49af4b96532e00b3a51574a2a94decb","success":1,"date_created":"2023-08-03T11:53:53Z","date_updated":"2023-08-03T11:53:53Z"},{"success":1,"checksum":"1b42eadcdd71f2dc00d82784673aa577","date_updated":"2023-08-03T11:53:54Z","date_created":"2023-08-03T11:53:54Z","file_id":"13543","relation":"main_file","creator":"jdanzl","file_size":16676449,"content_type":"image/tiff","access_level":"open_access","file_name":"Fig5_b_1.tif"},{"date_updated":"2023-08-03T11:53:54Z","date_created":"2023-08-03T11:53:54Z","success":1,"checksum":"0d27266bf216f71fcb5496731ce76dd5","file_id":"13544","relation":"main_file","creator":"jdanzl","file_size":427651,"content_type":"image/tiff","file_name":"Fig5_b_2-4.tif","access_level":"open_access"},{"creator":"jdanzl","file_size":11117705,"content_type":"image/tiff","access_level":"open_access","file_name":"Fig5_c_1-3.tif","success":1,"checksum":"c4232930068a0a8f7c8a70ce0ea48dc2","date_updated":"2023-08-03T11:53:55Z","date_created":"2023-08-03T11:53:55Z","file_id":"13545","relation":"main_file"},{"creator":"jdanzl","content_type":"image/tiff","file_size":254153,"file_name":"Fig5_c_2-4.tif","access_level":"open_access","date_updated":"2023-08-03T11:53:55Z","date_created":"2023-08-03T11:53:55Z","success":1,"checksum":"c9caad749be0ef04ef8013cfdb69f8fc","file_id":"13546","relation":"main_file"},{"relation":"main_file","file_id":"13547","checksum":"5c6d36b96bde1e090cc428b269aba6ec","success":1,"date_updated":"2023-08-03T11:54:14Z","date_created":"2023-08-03T11:54:14Z","access_level":"open_access","file_name":"Fig5_e_1.tif","file_size":737290746,"content_type":"image/tiff","creator":"jdanzl"},{"file_id":"13548","relation":"main_file","date_updated":"2023-08-03T11:53:57Z","date_created":"2023-08-03T11:53:57Z","success":1,"checksum":"f97632984b6a73e06cc0c8c947cdcc71","file_name":"Fig5_e_2.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":31366288},{"date_updated":"2023-08-03T11:53:57Z","date_created":"2023-08-03T11:53:57Z","success":1,"checksum":"8c471eeaa59008eed9e91afe5e1f1698","file_id":"13549","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":1216304,"file_name":"Fig5_e_3.tif","access_level":"open_access"},{"date_created":"2023-08-03T11:53:59Z","date_updated":"2023-08-03T11:53:59Z","checksum":"31c10c3a1d874b5028e35e2dd8800a68","success":1,"relation":"main_file","file_id":"13550","content_type":"image/tiff","file_size":35669193,"creator":"jdanzl","file_name":"Fig5_g.tif","access_level":"open_access"},{"file_name":"Fig5_h.tif","access_level":"open_access","content_type":"image/tiff","file_size":7492349,"creator":"jdanzl","relation":"main_file","file_id":"13551","date_updated":"2023-08-03T11:53:59Z","date_created":"2023-08-03T11:53:59Z","checksum":"0e9fe7b7ee06a630837e9d3c41b80e01","success":1},{"access_level":"open_access","file_name":"Fig6_a_1.tif","content_type":"image/tiff","file_size":121446390,"creator":"jdanzl","relation":"main_file","file_id":"13552","checksum":"d25b3d04bb8364089cafdf8deb6846b6","success":1,"date_created":"2023-08-03T11:59:18Z","date_updated":"2023-08-03T11:59:18Z"},{"file_name":"Fig6_a_2.tif","access_level":"open_access","creator":"jdanzl","file_size":264412158,"content_type":"image/tiff","file_id":"13553","relation":"main_file","date_updated":"2023-08-03T11:59:22Z","date_created":"2023-08-03T11:59:22Z","success":1,"checksum":"4361e10db6ec48c2d4579ac089ff3ca3"},{"creator":"jdanzl","file_size":57399051,"content_type":"image/tiff","access_level":"open_access","file_name":"Fig6_a_3.tif","success":1,"checksum":"fe3a00ae75fb3388438e53ced92a9498","date_updated":"2023-08-03T11:59:21Z","date_created":"2023-08-03T11:59:21Z","file_id":"13554","relation":"main_file"},{"relation":"main_file","file_id":"13555","date_updated":"2023-08-03T11:59:21Z","date_created":"2023-08-03T11:59:21Z","checksum":"4372c13d6dd2274aa749799b8e96bf06","success":1,"file_name":"Fig6_b_left.tif","access_level":"open_access","file_size":6003163,"content_type":"image/tiff","creator":"jdanzl"},{"file_size":511265,"content_type":"image/tiff","creator":"jdanzl","file_name":"Fig6_b_right.tif","access_level":"open_access","date_updated":"2023-08-03T11:59:21Z","date_created":"2023-08-03T11:59:21Z","checksum":"f7ae4e50f2f4d414c598bddd691b722a","success":1,"relation":"main_file","file_id":"13556"},{"creator":"jdanzl","content_type":"image/tiff","file_size":467125933,"access_level":"open_access","file_name":"Fig6_c_n2v.tif","success":1,"checksum":"cde658a9ca666bdef1b29613ab72092d","date_updated":"2023-08-03T11:59:39Z","date_created":"2023-08-03T11:59:39Z","file_id":"13557","relation":"main_file"},{"file_name":"Fig6_c.tif","access_level":"open_access","file_size":322251440,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13558","date_updated":"2023-08-03T11:59:36Z","date_created":"2023-08-03T11:59:36Z","checksum":"57e73c1fedcee4bd8ab62518baa0e0e5","success":1},{"date_created":"2023-08-03T11:59:38Z","date_updated":"2023-08-03T11:59:38Z","checksum":"53175073b83ab569241ae64ef7f180b3","success":1,"relation":"main_file","file_id":"13559","file_size":37641738,"content_type":"image/tiff","creator":"jdanzl","file_name":"Fig6_d_1.tif","access_level":"open_access"},{"file_id":"13560","relation":"main_file","date_updated":"2023-08-03T11:59:40Z","date_created":"2023-08-03T11:59:40Z","success":1,"checksum":"af97423e1077af85465a5e39fa25d1e4","file_name":"Fig6_d_2.tif","access_level":"open_access","creator":"jdanzl","file_size":70596929,"content_type":"image/tiff"},{"access_level":"open_access","file_name":"Fig6_d_3.tif","content_type":"image/tiff","file_size":15303146,"creator":"jdanzl","relation":"main_file","file_id":"13561","checksum":"f1fd7a9fa2a12a930fe35bdf53ba3ff7","success":1,"date_updated":"2023-08-03T11:59:42Z","date_created":"2023-08-03T11:59:42Z"},{"checksum":"95655df5cdb05f09912298de9a3711b4","success":1,"date_updated":"2023-08-03T11:59:41Z","date_created":"2023-08-03T11:59:41Z","relation":"main_file","file_id":"13562","file_size":893051,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Fig6_d_4.tif"},{"file_size":381232200,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Fig6_e.tif","checksum":"4d722b4e09ce617252d284f78ea2ee30","success":1,"date_created":"2023-08-03T11:59:58Z","date_updated":"2023-08-03T11:59:58Z","relation":"main_file","file_id":"13563"},{"content_type":"image/tiff","file_size":345804470,"creator":"jdanzl","access_level":"open_access","file_name":"Fig6_f.tif","checksum":"d1eda9599f422a614404dd112f0c3185","success":1,"date_updated":"2023-08-03T11:59:58Z","date_created":"2023-08-03T11:59:58Z","relation":"main_file","file_id":"13564"},{"creator":"jdanzl","content_type":"image/tiff","file_size":346119927,"file_name":"Fig6_g.tif","access_level":"open_access","date_created":"2023-08-03T12:00:08Z","date_updated":"2023-08-03T12:00:08Z","success":1,"checksum":"1cd202570f964b78e1f55c987d5d5de1","file_id":"13565","relation":"main_file"},{"file_size":7064977,"content_type":"image/tiff","creator":"jdanzl","file_name":"Fig6_h.tif","access_level":"open_access","date_updated":"2023-08-03T12:00:02Z","date_created":"2023-08-03T12:00:02Z","checksum":"78cbf1906ff8746ed524c62f8f580f52","success":1,"relation":"main_file","file_id":"13566"},{"success":1,"checksum":"21635ce59f1ae5a334aaad3f4c0b171c","date_updated":"2023-08-03T12:00:03Z","date_created":"2023-08-03T12:00:03Z","file_id":"13567","relation":"main_file","creator":"jdanzl","file_size":7110129,"content_type":"image/tiff","access_level":"open_access","file_name":"Fig6_i.tif"},{"creator":"jdanzl","content_type":"image/tiff","file_size":110297540,"file_name":"Fig6_j.tif","access_level":"open_access","date_created":"2023-08-03T12:00:07Z","date_updated":"2023-08-03T12:00:07Z","success":1,"checksum":"704962856f2a024ce1f321a1785556e3","file_id":"13568","relation":"main_file"},{"file_id":"13569","relation":"main_file","success":1,"checksum":"4b74ba5ae1e2bb2201bf51c74d733268","date_created":"2023-08-03T12:00:07Z","date_updated":"2023-08-03T12:00:07Z","access_level":"open_access","file_name":"Fig6_k.tif","creator":"jdanzl","content_type":"image/tiff","file_size":11117689},{"file_id":"13570","relation":"main_file","success":1,"checksum":"a8efa3007df4e9e0f80c7a2bbc451178","date_created":"2023-08-03T12:05:41Z","date_updated":"2023-08-03T12:05:41Z","access_level":"open_access","file_name":"Extdata_01_a_1.tif","creator":"jdanzl","file_size":1287107,"content_type":"image/tiff"},{"file_name":"Extdata_01_a_2.tif","access_level":"open_access","file_size":58307,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13571","date_updated":"2023-08-03T12:05:41Z","date_created":"2023-08-03T12:05:41Z","checksum":"7f24b6c84ce96a67347eb5ef4c43fac1","success":1},{"success":1,"checksum":"fa7ae4eefc11b9b60c4ab80f6e839b73","date_created":"2023-08-03T12:05:41Z","date_updated":"2023-08-03T12:05:41Z","file_id":"13572","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":1283209,"access_level":"open_access","file_name":"Extdata_01_a_3.tif"},{"relation":"main_file","file_id":"13573","checksum":"cec9a5eb87f1b56e64626a00c6d0e53d","success":1,"date_created":"2023-08-03T12:05:41Z","date_updated":"2023-08-03T12:05:41Z","access_level":"open_access","file_name":"Extdata_01_a_4.tif","content_type":"image/tiff","file_size":54409,"creator":"jdanzl"},{"file_size":2431,"content_type":"image/png","creator":"jdanzl","access_level":"open_access","file_name":"Extdata_01_c_1.png","checksum":"450e4786d66d5059028420153908a4dc","success":1,"date_updated":"2023-08-03T12:05:41Z","date_created":"2023-08-03T12:05:41Z","relation":"main_file","file_id":"13574"},{"file_name":"Extdata_01_c_2.png","access_level":"open_access","file_size":612,"content_type":"image/png","creator":"jdanzl","relation":"main_file","file_id":"13575","date_updated":"2023-08-03T12:05:41Z","date_created":"2023-08-03T12:05:41Z","checksum":"feb758609b399cf644dd3ae7cd75fb96","success":1},{"file_size":433981,"content_type":"image/tiff","creator":"jdanzl","file_name":"Extdata_01_d_1.tif","access_level":"open_access","date_created":"2023-08-03T12:05:41Z","date_updated":"2023-08-03T12:05:41Z","checksum":"52f43300a50f83f9a6ff1409324086ee","success":1,"relation":"main_file","file_id":"13576"},{"relation":"main_file","file_id":"13577","checksum":"28925dcf8792f524e286beb16b0c532c","success":1,"date_created":"2023-08-03T12:05:41Z","date_updated":"2023-08-03T12:05:41Z","access_level":"open_access","file_name":"Extdata_01_d_2.tif","content_type":"image/tiff","file_size":19649,"creator":"jdanzl"},{"relation":"main_file","file_id":"13578","date_created":"2023-08-03T12:05:41Z","date_updated":"2023-08-03T12:05:41Z","checksum":"c93b2f0426c80d18e252435f1e146568","success":1,"file_name":"Extdata_01_d_3.tif","access_level":"open_access","content_type":"image/tiff","file_size":433981,"creator":"jdanzl"},{"access_level":"open_access","file_name":"Extdata_01_d_4.tif","file_size":19649,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13579","checksum":"c0ed722a768001431f47646ef98c44da","success":1,"date_updated":"2023-08-03T12:05:41Z","date_created":"2023-08-03T12:05:41Z"},{"access_level":"open_access","file_name":"Extdata_01_f_1.png","creator":"jdanzl","content_type":"image/png","file_size":4752,"file_id":"13580","relation":"main_file","success":1,"checksum":"db9d386276b985b8e702f797e910bd0b","date_updated":"2023-08-03T12:05:41Z","date_created":"2023-08-03T12:05:41Z"},{"checksum":"244f6645d191c50d997c0dc6a15535ec","success":1,"date_updated":"2023-08-03T12:05:41Z","date_created":"2023-08-03T12:05:41Z","relation":"main_file","file_id":"13581","file_size":2698,"content_type":"image/png","creator":"jdanzl","access_level":"open_access","file_name":"Extdata_01_f_2.png"},{"creator":"jdanzl","file_size":24003247,"content_type":"image/tiff","access_level":"open_access","file_name":"Extdata_02_a.tif","success":1,"checksum":"3d6100b836d850b38e66e0f5a7919495","date_updated":"2023-08-03T12:07:27Z","date_created":"2023-08-03T12:07:27Z","file_id":"13582","relation":"main_file"},{"access_level":"open_access","file_name":"Extdata_02_b.tif","creator":"jdanzl","content_type":"image/tiff","file_size":1164723,"file_id":"13583","relation":"main_file","success":1,"checksum":"3cd6a3b7bf2061cf5c7810c0001236e5","date_created":"2023-08-03T12:07:27Z","date_updated":"2023-08-03T12:07:27Z"},{"file_name":"Extdata_03_SYPH1_xy_1.tif","access_level":"open_access","creator":"jdanzl","file_size":7109763,"content_type":"image/tiff","file_id":"13584","relation":"main_file","date_created":"2023-08-03T12:10:32Z","date_updated":"2023-08-03T12:10:32Z","success":1,"checksum":"d87c82d663ffea379cc86c56981e2e16"},{"creator":"jdanzl","content_type":"image/tiff","file_size":27791,"file_name":"Extdata_03_SYPH1_xz_1-2.tif","access_level":"open_access","date_updated":"2023-08-03T12:10:32Z","date_created":"2023-08-03T12:10:32Z","success":1,"checksum":"a3703d0d26393578d4ba466681fc6be8","file_id":"13585","relation":"main_file"},{"file_name":"Extdata_03_SYPH1_xz_3-4.tif","access_level":"open_access","file_size":27721,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13586","date_updated":"2023-08-03T12:10:32Z","date_created":"2023-08-03T12:10:32Z","checksum":"f653ac7d531cf9896cbd6a9edf2a7759","success":1},{"checksum":"04edbb337df4d5470e033a4f53c07300","success":1,"date_updated":"2023-08-03T12:10:33Z","date_created":"2023-08-03T12:10:33Z","relation":"main_file","file_id":"13587","content_type":"image/tiff","file_size":57657482,"creator":"jdanzl","access_level":"open_access","file_name":"Extdata_03_SYPH1_xz_n2v.tif"},{"date_created":"2023-08-03T12:10:34Z","date_updated":"2023-08-03T12:10:34Z","success":1,"checksum":"09e1fe2dd3a1e8349693fda55d0985ca","file_id":"13588","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":57657527,"file_name":"Extdata_03_SYPH1_xz.tif","access_level":"open_access"},{"creator":"jdanzl","content_type":"image/tiff","file_size":7109763,"file_name":"Extdata_03_SYP1_xy_1.tif","access_level":"open_access","date_created":"2023-08-03T12:12:25Z","date_updated":"2023-08-03T12:12:25Z","success":1,"checksum":"458f8d486cb63876c6664cde4a9be27c","file_id":"13589","relation":"main_file"},{"access_level":"open_access","file_name":"Extdata_03_SYP1_xy_2-3.tif","content_type":"image/tiff","file_size":72963,"creator":"jdanzl","relation":"main_file","file_id":"13590","checksum":"e2dfccc882d85b660d65a596e1a8cbac","success":1,"date_updated":"2023-08-03T12:12:25Z","date_created":"2023-08-03T12:12:25Z"},{"success":1,"checksum":"a331be6052c68cc027cdb79f15447d9a","date_created":"2023-08-03T12:12:25Z","date_updated":"2023-08-03T12:12:25Z","file_id":"13591","relation":"main_file","creator":"jdanzl","file_size":27724,"content_type":"image/tiff","access_level":"open_access","file_name":"Extdata_03_SYP1_xz_1-2.tif"},{"access_level":"open_access","file_name":"Extdata_03_SYP1_xz_3-4.tif","content_type":"image/tiff","file_size":27724,"creator":"jdanzl","relation":"main_file","file_id":"13592","checksum":"4de626b035b43feaacd923fca411e6a2","success":1,"date_updated":"2023-08-03T12:12:25Z","date_created":"2023-08-03T12:12:25Z"},{"relation":"main_file","file_id":"13593","date_updated":"2023-08-03T12:12:30Z","date_created":"2023-08-03T12:12:30Z","checksum":"d8076e927a074f024924d9bdb6fdd5e6","success":1,"file_name":"Extdata_03_SYP1_xz_n2v.tif","access_level":"open_access","content_type":"image/tiff","file_size":214613644,"creator":"jdanzl"},{"file_size":214613687,"content_type":"image/tiff","creator":"jdanzl","file_name":"Extdata_03_SYP1_xz.tif","access_level":"open_access","date_updated":"2023-08-03T12:12:30Z","date_created":"2023-08-03T12:12:30Z","checksum":"79cf7d0f450c397caa877dd06b52f8df","success":1,"relation":"main_file","file_id":"13594"},{"file_size":7109747,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Extdata03_VAMP2_xy_1.tif","checksum":"60ac6ea988d9b8bdaba2f09e0e1ef370","success":1,"date_created":"2023-08-03T12:14:29Z","date_updated":"2023-08-03T12:14:29Z","relation":"main_file","file_id":"13595"},{"file_name":"Extdata03_VAMP2_xy_2-3.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":72947,"file_id":"13596","relation":"main_file","date_updated":"2023-08-03T12:14:29Z","date_created":"2023-08-03T12:14:29Z","success":1,"checksum":"92bf312da2dd356aa4fc9a0e7d811af2"},{"file_name":"Extdata03_VAMP2_xz_1-2.tif","access_level":"open_access","creator":"jdanzl","file_size":27724,"content_type":"image/tiff","file_id":"13597","relation":"main_file","date_updated":"2023-08-03T12:14:29Z","date_created":"2023-08-03T12:14:29Z","success":1,"checksum":"9319e293092eeee24e3c658fc178af1a"},{"file_name":"Extdata03_VAMP2_xz_3-4.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":27708,"file_id":"13598","relation":"main_file","date_updated":"2023-08-03T12:14:29Z","date_created":"2023-08-03T12:14:29Z","success":1,"checksum":"a627d7fd9a89bdde968e6d9bff846254"},{"file_id":"13599","relation":"main_file","success":1,"checksum":"7a5363a185edce59ce57535f7d855092","date_created":"2023-08-03T12:14:32Z","date_updated":"2023-08-03T12:14:32Z","access_level":"open_access","file_name":"Extdata03_VAMP2_xz_n2v.tif","creator":"jdanzl","file_size":102457485,"content_type":"image/tiff"},{"access_level":"open_access","file_name":"Extdata03_VAMP2_xz.tif","creator":"jdanzl","content_type":"image/tiff","file_size":102457527,"file_id":"13600","relation":"main_file","success":1,"checksum":"8e7fc4d00fff8ec6d9340e969f37e176","date_created":"2023-08-03T12:14:32Z","date_updated":"2023-08-03T12:14:32Z"},{"access_level":"open_access","file_name":"Extdata04_VGLUT_xy_1.tif","creator":"jdanzl","content_type":"image/tiff","file_size":11117763,"file_id":"13601","relation":"main_file","success":1,"checksum":"be17472f73ed8cd02a700b861f1dbac0","date_created":"2023-08-03T12:16:08Z","date_updated":"2023-08-03T12:16:08Z"},{"relation":"main_file","file_id":"13602","date_updated":"2023-08-03T12:16:08Z","date_created":"2023-08-03T12:16:08Z","checksum":"dbc3ec477f491ce3e98ab40475bd90ca","success":1,"file_name":"Extdata04_VGLUT_xy_2-3.tif","access_level":"open_access","file_size":72947,"content_type":"image/tiff","creator":"jdanzl"},{"content_type":"image/tiff","file_size":53367,"creator":"jdanzl","file_name":"Extdata04_VGLUT_xz_1-2.tif","access_level":"open_access","date_updated":"2023-08-03T12:16:08Z","date_created":"2023-08-03T12:16:08Z","checksum":"8ee877e6b843bb0e38febb0481962d69","success":1,"relation":"main_file","file_id":"13603"},{"success":1,"checksum":"9873f54d50955a2c204d0559c87aa13d","date_created":"2023-08-03T12:16:08Z","date_updated":"2023-08-03T12:16:08Z","file_id":"13604","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":53358,"access_level":"open_access","file_name":"Extdata04_VGLUT_xz_3-4.tif"},{"relation":"main_file","file_id":"13605","date_updated":"2023-08-03T12:16:11Z","date_created":"2023-08-03T12:16:11Z","checksum":"8eda08ae5981fcfa3758d0320b1923af","success":1,"file_name":"Extdata04_VGLUT_xz_n2v.tif","access_level":"open_access","content_type":"image/tiff","file_size":144076208,"creator":"jdanzl"},{"file_name":"Extdata04_VGLUT_xz.tif","access_level":"open_access","content_type":"image/tiff","file_size":72071440,"creator":"jdanzl","relation":"main_file","file_id":"13606","date_updated":"2023-08-03T12:16:10Z","date_created":"2023-08-03T12:16:10Z","checksum":"bc0b10229d498f60996a5b05cb87c428","success":1},{"file_name":"Extdata03_VGAT_xy_1.tif","access_level":"open_access","file_size":7109763,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13607","date_created":"2023-08-03T12:32:32Z","date_updated":"2023-08-03T12:32:32Z","checksum":"e8d093ce7d98ea5647d8a80e3084c40b","success":1},{"file_size":72947,"content_type":"image/tiff","creator":"jdanzl","file_name":"Extdata03_VGAT_xy_2-3.tif","access_level":"open_access","date_updated":"2023-08-03T12:32:32Z","date_created":"2023-08-03T12:32:32Z","checksum":"36590ca7a586de7ad76d3ad659c38995","success":1,"relation":"main_file","file_id":"13608"},{"file_id":"13609","relation":"main_file","date_created":"2023-08-03T12:32:32Z","date_updated":"2023-08-03T12:32:32Z","success":1,"checksum":"3914c7709f69d4d18f23a9fb6dc64572","file_name":"Extdata03_VGAT_xz_1-2.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":53355},{"file_name":"Extdata03_VGAT_xz_3-4.tif","access_level":"open_access","content_type":"image/tiff","file_size":53339,"creator":"jdanzl","relation":"main_file","file_id":"13610","date_created":"2023-08-03T12:32:32Z","date_updated":"2023-08-03T12:32:32Z","checksum":"fa98aa521adaefb9e4476fe519e88e59","success":1},{"date_created":"2023-08-03T12:32:36Z","date_updated":"2023-08-03T12:32:36Z","checksum":"cd6f384c51756977e37f45043c913252","success":1,"relation":"main_file","file_id":"13611","content_type":"image/tiff","file_size":204861338,"creator":"jdanzl","file_name":"Extdata03_VGAT_xz_n2v.tif","access_level":"open_access"},{"access_level":"open_access","file_name":"Extdata03_VGAT_xz.tif","creator":"jdanzl","file_size":102457527,"content_type":"image/tiff","file_id":"13612","relation":"main_file","success":1,"checksum":"fb7e46feda5ac07877a91ad963da0e31","date_created":"2023-08-03T12:32:35Z","date_updated":"2023-08-03T12:32:35Z"},{"success":1,"checksum":"fe033e0a377d391cd8e4af04987d9900","date_created":"2023-08-03T12:36:46Z","date_updated":"2023-08-03T12:36:46Z","file_id":"13613","relation":"main_file","creator":"jdanzl","content_type":"image/png","file_size":4348932,"access_level":"open_access","file_name":"Extdata04_MUNC_xy_1.png"},{"relation":"main_file","file_id":"13614","date_updated":"2023-08-03T12:35:58Z","date_created":"2023-08-03T12:35:58Z","checksum":"771d8e2b9192b6620f54ab30e4fad594","success":1,"file_name":"Extdata04_MUNC_xy_2-3.tif","access_level":"open_access","file_size":72947,"content_type":"image/tiff","creator":"jdanzl"},{"date_updated":"2023-08-03T12:35:58Z","date_created":"2023-08-03T12:35:58Z","success":1,"checksum":"4256d8f06fa2077b352776cf76b46618","file_id":"13615","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":53435,"file_name":"Extdata04_MUNC_xz_1-2.tif","access_level":"open_access"},{"access_level":"open_access","file_name":"Extdata04_MUNC_xz_3-4.tif","file_size":55941,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13616","checksum":"0b9365638c81d545e773170cf04b04b8","success":1,"date_updated":"2023-08-03T12:35:58Z","date_created":"2023-08-03T12:35:58Z"},{"file_id":"13617","relation":"main_file","success":1,"checksum":"9fa62688dab03c592cec47bf5d1c304d","date_updated":"2023-08-03T12:36:04Z","date_created":"2023-08-03T12:36:04Z","access_level":"open_access","file_name":"Extdata04_MUNC_xz_n2v.tif","creator":"jdanzl","file_size":204861404,"content_type":"image/tiff"},{"checksum":"39f710080a26136dbbe4c8916b434c65","success":1,"date_updated":"2023-08-03T12:36:02Z","date_created":"2023-08-03T12:36:02Z","relation":"main_file","file_id":"13618","file_size":102457527,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Extdata04_MUNC_xz.tif"},{"relation":"main_file","file_id":"13619","checksum":"eaabc8112645a73f4326e621b4e6ad0a","success":1,"date_created":"2023-08-03T12:38:39Z","date_updated":"2023-08-03T12:38:39Z","access_level":"open_access","file_name":"Extdata04_BASSOON_xy_1.tif","file_size":11117757,"content_type":"image/tiff","creator":"jdanzl"},{"access_level":"open_access","file_name":"Extdata04_BASSOON_xy_2-3.tif","creator":"jdanzl","content_type":"image/tiff","file_size":74041,"file_id":"13620","relation":"main_file","success":1,"checksum":"15f624d29c473ce6e0ae7e466efc059a","date_created":"2023-08-03T12:38:39Z","date_updated":"2023-08-03T12:38:39Z"},{"relation":"main_file","file_id":"13621","checksum":"1cb4b4d219767a30072c804a07140240","success":1,"date_created":"2023-08-03T12:38:39Z","date_updated":"2023-08-03T12:38:39Z","access_level":"open_access","file_name":"Extdata04_BASSOON_xz_1-2.tif","file_size":53435,"content_type":"image/tiff","creator":"jdanzl"},{"relation":"main_file","file_id":"13622","date_updated":"2023-08-03T12:38:39Z","date_created":"2023-08-03T12:38:39Z","checksum":"1bac9c192da9375d81cb3747f48c9be4","success":1,"file_name":"Extdata04_BASSOON_xz_3-4.tif","access_level":"open_access","content_type":"image/tiff","file_size":53362,"creator":"jdanzl"},{"checksum":"57fa91bfb1e2937e3449e57096b6fc74","success":1,"date_created":"2023-08-03T12:38:50Z","date_updated":"2023-08-03T12:38:50Z","relation":"main_file","file_id":"13623","file_size":576071410,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Extdata04_BASSOON_xz_n2v.tif"},{"creator":"jdanzl","file_size":288066640,"content_type":"image/tiff","file_name":"Extdata04_BASSOON_xz.tif","access_level":"open_access","date_created":"2023-08-03T12:38:46Z","date_updated":"2023-08-03T12:38:46Z","success":1,"checksum":"ac51a734dcf7d1b94afcd4a471f10626","file_id":"13624","relation":"main_file"},{"file_id":"13625","relation":"main_file","date_created":"2023-08-03T12:40:57Z","date_updated":"2023-08-03T12:40:57Z","success":1,"checksum":"244043f7acba250d560e29123702dcd7","file_name":"Extdata04_HOMER1_xy_1.tif","access_level":"open_access","creator":"jdanzl","file_size":7109763,"content_type":"image/tiff"},{"checksum":"eff51ff97539f6491989bfc3d3f88860","success":1,"date_created":"2023-08-03T12:40:57Z","date_updated":"2023-08-03T12:40:57Z","relation":"main_file","file_id":"13626","file_size":72963,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Extdata04_HOMER1_xy_2-3.tif"},{"access_level":"open_access","file_name":"Extdata04_HOMER1_xz_1-2.tif","file_size":53375,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13627","checksum":"df35046d9bca4e97a5625c5a55218cfb","success":1,"date_created":"2023-08-03T12:40:57Z","date_updated":"2023-08-03T12:40:57Z"},{"relation":"main_file","file_id":"13628","date_updated":"2023-08-03T12:40:57Z","date_created":"2023-08-03T12:40:57Z","checksum":"5dc7536f7aaea084dfc329537d8412ce","success":1,"file_name":"Extdata04_HOMER1_xz_3-4.tif","access_level":"open_access","content_type":"image/tiff","file_size":53359,"creator":"jdanzl"},{"checksum":"0b407669a26b9d7730a41361ceffda9a","success":1,"date_created":"2023-08-03T12:41:00Z","date_updated":"2023-08-03T12:41:00Z","relation":"main_file","file_id":"13629","file_size":204861339,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Extdata04_HOMER1_xz_n2v.tif"},{"date_updated":"2023-08-03T12:40:59Z","date_created":"2023-08-03T12:40:59Z","success":1,"checksum":"f95a0da9bea8b605fc2ed310190836b3","file_id":"13630","relation":"main_file","creator":"jdanzl","file_size":102457527,"content_type":"image/tiff","file_name":"Extdata04_HOMER1_xz.tif","access_level":"open_access"},{"creator":"jdanzl","content_type":"image/tiff","file_size":7120361,"access_level":"open_access","file_name":"Extdata04_SHANK2_xy_1.tif","success":1,"checksum":"cf74307696548e7aa90e59a0935a74a1","date_updated":"2023-08-03T12:45:08Z","date_created":"2023-08-03T12:45:08Z","file_id":"13631","relation":"main_file"},{"file_name":"Extdata04_SHANK2_xy_2-3.tif","access_level":"open_access","content_type":"image/tiff","file_size":72973,"creator":"jdanzl","relation":"main_file","file_id":"13632","date_created":"2023-08-03T12:45:08Z","date_updated":"2023-08-03T12:45:08Z","checksum":"7b3490246df4f5bb68d0df682161820f","success":1},{"date_updated":"2023-08-03T12:45:08Z","date_created":"2023-08-03T12:45:08Z","checksum":"c599d6830e61c386219e266f4717fe7c","success":1,"relation":"main_file","file_id":"13633","file_size":53443,"content_type":"image/tiff","creator":"jdanzl","file_name":"Extdata04_SHANK2_xz_1-2.tif","access_level":"open_access"},{"relation":"main_file","file_id":"13634","checksum":"5b9912b2a408d224ad669f39dc8d5bc6","success":1,"date_updated":"2023-08-03T12:45:08Z","date_created":"2023-08-03T12:45:08Z","access_level":"open_access","file_name":"Extdata04_SHANK2_xz_3-4.tif","content_type":"image/tiff","file_size":53362,"creator":"jdanzl"},{"relation":"main_file","file_id":"13635","date_updated":"2023-08-03T12:45:30Z","date_created":"2023-08-03T12:45:30Z","checksum":"17f2064ceeb99cbb51208c27b1961ed5","success":1,"file_name":"Extdata04_SHANK2_xz_n2v.tif","access_level":"open_access","content_type":"image/tiff","file_size":691291157,"creator":"jdanzl"},{"content_type":"image/tiff","file_size":518519275,"creator":"jdanzl","access_level":"open_access","file_name":"Extdata04_SHANK2_xz.tif","checksum":"21f1bb8d2a00c88bdd6febe6285acc2a","success":1,"date_updated":"2023-08-03T12:45:26Z","date_created":"2023-08-03T12:45:26Z","relation":"main_file","file_id":"13636"},{"file_size":752109,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Extdata04_GEPHYRIN_xy_1.tif","checksum":"47597ca873f1ea81cd4f7e9bfbb34aa4","success":1,"date_created":"2023-08-03T12:46:25Z","date_updated":"2023-08-03T12:46:25Z","relation":"main_file","file_id":"13637"},{"creator":"jdanzl","content_type":"image/tiff","file_size":72909,"file_name":"Extdata04_GEPHYRIN_xy_2-3.tif","access_level":"open_access","date_created":"2023-08-03T12:46:25Z","date_updated":"2023-08-03T12:46:25Z","success":1,"checksum":"14ed7ae64eb783e6b30f824f21959d0f","file_id":"13638","relation":"main_file"},{"creator":"jdanzl","file_size":53375,"content_type":"image/tiff","file_name":"Extdata04_GEPHYRIN_xz_1-2.tif","access_level":"open_access","date_updated":"2023-08-03T12:46:25Z","date_created":"2023-08-03T12:46:25Z","success":1,"checksum":"e361e226428d7b23618eed35b1cad080","file_id":"13639","relation":"main_file"},{"date_updated":"2023-08-03T12:46:25Z","date_created":"2023-08-03T12:46:25Z","checksum":"abe7cee22f69fc2bf1a3ff9955ccf45a","success":1,"relation":"main_file","file_id":"13640","file_size":53360,"content_type":"image/tiff","creator":"jdanzl","file_name":"Extdata04_GEPHYRIN_xz_3-4.tif","access_level":"open_access"},{"file_name":"Extdata04_GEPHYRIN_xz_n2v.tif","access_level":"open_access","file_size":73174939,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13641","date_updated":"2023-08-03T12:46:27Z","date_created":"2023-08-03T12:46:27Z","checksum":"59b49b451a63c5ac06fa31a17640c1a2","success":1},{"file_id":"13642","relation":"main_file","date_updated":"2023-08-03T12:46:26Z","date_created":"2023-08-03T12:46:26Z","success":1,"checksum":"1ee1feea85c8319ebc6c49147502e412","file_name":"Extdata04_GEPHYRIN_xz.tif","access_level":"open_access","creator":"jdanzl","file_size":36614327,"content_type":"image/tiff"},{"date_updated":"2023-08-03T12:52:23Z","date_created":"2023-08-03T12:52:23Z","checksum":"64d9d868ef89c5cfc65cb199aff831b4","success":1,"relation":"main_file","file_id":"13643","content_type":"image/tiff","file_size":2195652677,"creator":"jdanzl","file_name":"Extdata06_a-b_n2v.tif","access_level":"open_access"},{"file_size":1097875840,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Extdata06_a-b.tif","checksum":"df41d97987798715b1f66e6e72be169b","success":1,"date_updated":"2023-08-03T12:51:41Z","date_created":"2023-08-03T12:51:41Z","relation":"main_file","file_id":"13644"},{"content_type":"image/tiff","file_size":3564577,"creator":"jdanzl","file_name":"Extdata07_01_bottom.tif","access_level":"open_access","date_created":"2023-08-03T12:52:57Z","date_updated":"2023-08-03T12:52:57Z","checksum":"95a3eaa3b70e964f6871a5765a53659b","success":1,"relation":"main_file","file_id":"13645"},{"creator":"jdanzl","content_type":"image/tiff","file_size":11958844,"access_level":"open_access","file_name":"Extdata07_01_top.tif","success":1,"checksum":"80b41ad0de73fd61eb67a35262627fac","date_updated":"2023-08-03T12:52:57Z","date_created":"2023-08-03T12:52:57Z","file_id":"13646","relation":"main_file"},{"access_level":"open_access","file_name":"Extdata07_2_bottom.tif","creator":"jdanzl","file_size":3564581,"content_type":"image/tiff","file_id":"13647","relation":"main_file","success":1,"checksum":"f694a0f11e2f782702cb4c411941873a","date_created":"2023-08-03T12:54:27Z","date_updated":"2023-08-03T12:54:27Z"},{"content_type":"image/tiff","file_size":11973592,"creator":"jdanzl","file_name":"Extdata07_2_top.tif","access_level":"open_access","date_updated":"2023-08-03T12:54:27Z","date_created":"2023-08-03T12:54:27Z","checksum":"b8b1a1339a25806615c0aa7906a032ff","success":1,"relation":"main_file","file_id":"13648"},{"creator":"jdanzl","content_type":"image/tiff","file_size":1281901,"access_level":"open_access","file_name":"Extdata07_3_bottom.tif","success":1,"checksum":"8a24eb623d65d809fe8afbd527528a77","date_updated":"2023-08-03T12:54:27Z","date_created":"2023-08-03T12:54:27Z","file_id":"13649","relation":"main_file"},{"file_id":"13650","relation":"main_file","success":1,"checksum":"816b35def703bc48d55b0293fcd8212f","date_updated":"2023-08-03T12:54:27Z","date_created":"2023-08-03T12:54:27Z","access_level":"open_access","file_name":"Extdata07_3_top.tif","creator":"jdanzl","file_size":16569776,"content_type":"image/tiff"},{"file_id":"13651","relation":"main_file","success":1,"checksum":"7f1375ab8cf28cd136e2e44d1fdfd87d","date_created":"2023-08-03T12:54:27Z","date_updated":"2023-08-03T12:54:27Z","access_level":"open_access","file_name":"Extdata07_04_bottom.tif","creator":"jdanzl","file_size":3564595,"content_type":"image/tiff"},{"file_name":"Extdata07_04_top.tif","access_level":"open_access","content_type":"image/tiff","file_size":5896404,"creator":"jdanzl","relation":"main_file","file_id":"13652","date_created":"2023-08-03T12:54:27Z","date_updated":"2023-08-03T12:54:27Z","checksum":"b1dbda28e2a010968716c0411568f139","success":1},{"content_type":"image/tiff","file_size":3564609,"creator":"jdanzl","access_level":"open_access","file_name":"Extdata07_5_bottom.tif","checksum":"d6e96b7c8e6a7084c14eda83a4dd778a","success":1,"date_updated":"2023-08-03T12:54:28Z","date_created":"2023-08-03T12:54:28Z","relation":"main_file","file_id":"13653"},{"creator":"jdanzl","file_size":15555618,"content_type":"image/tiff","file_name":"Extdata07_5_top.tif","access_level":"open_access","date_created":"2023-08-03T12:54:28Z","date_updated":"2023-08-03T12:54:28Z","success":1,"checksum":"a647f89a3048f71512cc58c9e53ec022","file_id":"13654","relation":"main_file"},{"relation":"main_file","file_id":"13655","date_updated":"2023-08-03T12:54:28Z","date_created":"2023-08-03T12:54:28Z","checksum":"66becb046fe591914df572617d720202","success":1,"file_name":"Extdata07_6_bottom.tif","access_level":"open_access","content_type":"image/tiff","file_size":3564577,"creator":"jdanzl"},{"access_level":"open_access","file_name":"Extdata07_6_top.tif","creator":"jdanzl","content_type":"image/tiff","file_size":6038186,"file_id":"13656","relation":"main_file","success":1,"checksum":"5d76b2ad7d7acbb1afa27cf52194b1cb","date_updated":"2023-08-03T12:54:28Z","date_created":"2023-08-03T12:54:28Z"},{"file_id":"13657","relation":"main_file","date_created":"2023-08-03T12:54:28Z","date_updated":"2023-08-03T12:54:28Z","success":1,"checksum":"7f137bdea0f0acb3db75c983ce44ab44","file_name":"Extdata07_7_bottom.tif","access_level":"open_access","creator":"jdanzl","file_size":3560937,"content_type":"image/tiff"},{"date_created":"2023-08-03T12:54:28Z","date_updated":"2023-08-03T12:54:28Z","checksum":"479e26106280eb61a2d74e29137a2e43","success":1,"relation":"main_file","file_id":"13658","content_type":"image/tiff","file_size":12031850,"creator":"jdanzl","file_name":"Extdata07_7_top.tif","access_level":"open_access"},{"relation":"main_file","file_id":"13659","checksum":"8426197ad283c1bc83e3193f323d5f5a","success":1,"date_updated":"2023-08-03T12:54:28Z","date_created":"2023-08-03T12:54:28Z","access_level":"open_access","file_name":"Extdata07_8_bottom.tif","content_type":"image/tiff","file_size":3560937,"creator":"jdanzl"},{"file_name":"Extdata07_8_top.tif","access_level":"open_access","content_type":"image/tiff","file_size":22877176,"creator":"jdanzl","relation":"main_file","file_id":"13660","date_updated":"2023-08-03T12:54:28Z","date_created":"2023-08-03T12:54:28Z","checksum":"b9f75a82b564e1c5c363a495d078f6b7","success":1},{"file_name":"Extdata07_9_bottom.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":3564605,"file_id":"13661","relation":"main_file","date_created":"2023-08-03T12:54:28Z","date_updated":"2023-08-03T12:54:28Z","success":1,"checksum":"7f1a9f3bb9611362995ae832b2607f4d"},{"creator":"jdanzl","content_type":"image/tiff","file_size":2744190,"access_level":"open_access","file_name":"Extdata07_9_top.tif","success":1,"checksum":"40286bcb876b655d7421534d0215e86b","date_created":"2023-08-03T12:54:28Z","date_updated":"2023-08-03T12:54:28Z","file_id":"13662","relation":"main_file"},{"date_updated":"2023-08-03T13:00:03Z","date_created":"2023-08-03T13:00:03Z","checksum":"4af220986cc94d412c2354aa7e6c8cce","success":1,"relation":"main_file","file_id":"13663","content_type":"image/png","file_size":7243611,"creator":"jdanzl","file_name":"Extdata08_6_left.png","access_level":"open_access"},{"date_created":"2023-08-03T13:00:03Z","date_updated":"2023-08-03T13:00:03Z","success":1,"checksum":"af9c2299f1005a3ccc39f41082cea642","file_id":"13664","relation":"main_file","creator":"jdanzl","file_size":5562487,"content_type":"image/tiff","file_name":"Extdata08_6_right.tif","access_level":"open_access"},{"file_size":34745956,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Extdata08_7_left.tif","checksum":"63ef28a174215c70e31d2cabf67d90fc","success":1,"date_updated":"2023-08-03T13:00:04Z","date_created":"2023-08-03T13:00:04Z","relation":"main_file","file_id":"13665"},{"file_name":"Extdata08_7_right.tif","access_level":"open_access","creator":"jdanzl","file_size":5562483,"content_type":"image/tiff","file_id":"13666","relation":"main_file","date_created":"2023-08-03T13:00:03Z","date_updated":"2023-08-03T13:00:03Z","success":1,"checksum":"46de918dfe5f3c23e497ee3daa608dd9"},{"file_id":"13667","relation":"main_file","success":1,"checksum":"8243a7985d2902446183adc35519a0c8","date_updated":"2023-08-03T13:00:04Z","date_created":"2023-08-03T13:00:04Z","access_level":"open_access","file_name":"Extdata08_b_1_left.tif","creator":"jdanzl","content_type":"image/tiff","file_size":31506150},{"file_id":"13668","relation":"main_file","date_updated":"2023-08-03T13:00:04Z","date_created":"2023-08-03T13:00:04Z","success":1,"checksum":"857cffa31569efcd5917f9802a106d58","file_name":"Extdata08_b_1_right.tif","access_level":"open_access","creator":"jdanzl","file_size":11117705,"content_type":"image/tiff"},{"date_updated":"2023-08-03T13:00:04Z","date_created":"2023-08-03T13:00:04Z","checksum":"e34902de9119d2cd9f1910f610627c5f","success":1,"relation":"main_file","file_id":"13669","content_type":"image/png","file_size":3540493,"creator":"jdanzl","file_name":"Extdata08_b_2_left.png","access_level":"open_access"},{"file_name":"Extdata08_b_2_right.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":5562553,"file_id":"13670","relation":"main_file","date_updated":"2023-08-03T13:00:05Z","date_created":"2023-08-03T13:00:05Z","success":1,"checksum":"1247d636ac5af22e8950ffd2ff213fea"},{"checksum":"f47c2d3f6824e08853ae2631f6ee7c5f","success":1,"date_updated":"2023-08-03T13:00:05Z","date_created":"2023-08-03T13:00:05Z","relation":"main_file","file_id":"13671","content_type":"image/png","file_size":3541547,"creator":"jdanzl","access_level":"open_access","file_name":"Extdata08_b_3_left.png"},{"file_id":"13672","relation":"main_file","date_updated":"2023-08-03T13:00:05Z","date_created":"2023-08-03T13:00:05Z","success":1,"checksum":"1247d636ac5af22e8950ffd2ff213fea","file_name":"Extdata08_b_3_right.tif","access_level":"open_access","creator":"jdanzl","file_size":5562553,"content_type":"image/tiff"},{"content_type":"image/tiff","file_size":25819844,"creator":"jdanzl","access_level":"open_access","file_name":"Extdata08_b_4_left.tif","checksum":"e90a95ec902a683678acd70336852fd9","success":1,"date_created":"2023-08-03T13:00:05Z","date_updated":"2023-08-03T13:00:05Z","relation":"main_file","file_id":"13673"},{"success":1,"checksum":"94cd44cd1c8c7a87ffd5861bf88561a1","date_created":"2023-08-03T13:00:05Z","date_updated":"2023-08-03T13:00:05Z","file_id":"13674","relation":"main_file","creator":"jdanzl","file_size":5561131,"content_type":"image/tiff","access_level":"open_access","file_name":"Extdata08_b_4_right.tif"},{"checksum":"fd4ca56dc5c48ad4546df22daef04efc","success":1,"date_created":"2023-08-03T13:00:06Z","date_updated":"2023-08-03T13:00:06Z","relation":"main_file","file_id":"13675","file_size":38786287,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Extdata08_b_5_left.tif"},{"checksum":"52c04890160c4e0f23d3fe2d3ed0c8e7","success":1,"date_updated":"2023-08-03T13:00:06Z","date_created":"2023-08-03T13:00:06Z","relation":"main_file","file_id":"13676","file_size":5562487,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Extdata08_b_5_right.tif"},{"file_name":"Extdata08_a_1-1.png","access_level":"open_access","content_type":"image/png","file_size":2133527,"creator":"jdanzl","relation":"main_file","file_id":"13677","date_created":"2023-08-03T13:04:52Z","date_updated":"2023-08-03T13:04:52Z","checksum":"47ee6f4b083130d5bb720bcf8a832443","success":1},{"checksum":"5ca2279c372b3b7dbce3ea5658a68399","success":1,"date_updated":"2023-08-03T13:04:52Z","date_created":"2023-08-03T13:04:52Z","relation":"main_file","file_id":"13678","file_size":1782607,"content_type":"image/png","creator":"jdanzl","access_level":"open_access","file_name":"Extdata08_a_1-2.png"},{"relation":"main_file","file_id":"13679","checksum":"34b7781e3e4abf9f30a0c85db156b6d5","success":1,"date_updated":"2023-08-03T13:04:52Z","date_created":"2023-08-03T13:04:52Z","access_level":"open_access","file_name":"Extdata08_a_2.png","file_size":5117469,"content_type":"image/png","creator":"jdanzl"},{"file_name":"Extdata08_a_3.png","access_level":"open_access","file_size":6911658,"content_type":"image/png","creator":"jdanzl","relation":"main_file","file_id":"13680","date_created":"2023-08-03T13:04:52Z","date_updated":"2023-08-03T13:04:52Z","checksum":"25717007393682098d2208bd0676a0f7","success":1},{"file_name":"Extdata08_a_4.png","access_level":"open_access","creator":"jdanzl","file_size":8579427,"content_type":"image/png","file_id":"13681","relation":"main_file","date_updated":"2023-08-03T13:04:53Z","date_created":"2023-08-03T13:04:53Z","success":1,"checksum":"b4b003809acec33c71628066744c7ea9"},{"file_name":"Extdata08_a_5.png","access_level":"open_access","creator":"jdanzl","content_type":"image/png","file_size":9675065,"file_id":"13682","relation":"main_file","date_updated":"2023-08-03T13:04:53Z","date_created":"2023-08-03T13:04:53Z","success":1,"checksum":"4410976cf867ecacf8f197dbd28cc5a0"},{"file_name":"Extdata08_a_6.png","access_level":"open_access","creator":"jdanzl","content_type":"image/png","file_size":9769588,"file_id":"13683","relation":"main_file","date_created":"2023-08-03T13:04:53Z","date_updated":"2023-08-03T13:04:53Z","success":1,"checksum":"a235dd204f28d3323883e044b031b984"},{"success":1,"checksum":"0e2b768e4eb7200cf6fe28ba511a5ef6","date_created":"2023-08-03T13:04:53Z","date_updated":"2023-08-03T13:04:53Z","file_id":"13684","relation":"main_file","creator":"jdanzl","file_size":9114791,"content_type":"image/png","access_level":"open_access","file_name":"Extdata08_a_7.png"},{"file_id":"13685","relation":"main_file","success":1,"checksum":"df4a01c62233ee8ed601c4b90d7780d0","date_created":"2023-08-03T13:04:57Z","date_updated":"2023-08-03T13:04:57Z","access_level":"open_access","file_name":"Extdata08_a_8.png","creator":"jdanzl","content_type":"image/png","file_size":124540688},{"file_name":"Exdata09_c_n2v.tif","access_level":"open_access","file_size":204861336,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13686","date_updated":"2023-08-03T13:11:30Z","date_created":"2023-08-03T13:11:30Z","checksum":"1f407c7915e2717a56fec258708e7b7a","success":1},{"access_level":"open_access","file_name":"Extdata09_a_zoom.tif","creator":"jdanzl","content_type":"image/tiff","file_size":252149,"file_id":"13687","relation":"main_file","success":1,"checksum":"9089dc7c9914edf9750eebd65819708d","date_created":"2023-08-03T13:11:26Z","date_updated":"2023-08-03T13:11:26Z"},{"file_size":11117705,"content_type":"image/tiff","creator":"jdanzl","file_name":"Extdata09_a.tif","access_level":"open_access","date_updated":"2023-08-03T13:11:26Z","date_created":"2023-08-03T13:11:26Z","checksum":"62d295a62cb8dd36c268b28cf0251322","success":1,"relation":"main_file","file_id":"13688"},{"file_id":"13689","relation":"main_file","date_updated":"2023-08-03T13:11:31Z","date_created":"2023-08-03T13:11:31Z","success":1,"checksum":"e874d8ee287f924c1076134b5b06bdb2","file_name":"Extdata09_b_n2v.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":256074660},{"access_level":"open_access","file_name":"Extdata10_n2v_CLAHE.tif","creator":"jdanzl","file_size":127914854,"content_type":"image/tiff","file_id":"13690","relation":"main_file","success":1,"checksum":"488068fff7b42bcf5728739e2a06d742","date_created":"2023-08-03T13:12:53Z","date_updated":"2023-08-03T13:12:53Z"},{"date_updated":"2023-08-03T13:21:35Z","date_created":"2023-08-03T13:21:35Z","success":1,"checksum":"35351f5af21ce854d41577813a7bdb57","file_id":"13691","relation":"main_file","creator":"jdanzl","file_size":430878,"content_type":"image/png","file_name":"Supplfig01_a_1.png","access_level":"open_access"},{"checksum":"36204e9e604206366ffc6f61ec91915b","success":1,"date_updated":"2023-08-03T13:21:35Z","date_created":"2023-08-03T13:21:35Z","relation":"main_file","file_id":"13692","file_size":438843,"content_type":"image/png","creator":"jdanzl","access_level":"open_access","file_name":"Supplfig01_a_2.png"},{"file_name":"Supplfig01_a_3.png","access_level":"open_access","creator":"jdanzl","content_type":"image/png","file_size":426713,"file_id":"13693","relation":"main_file","date_updated":"2023-08-03T13:21:35Z","date_created":"2023-08-03T13:21:35Z","success":1,"checksum":"92ccc934c4603b29f4f7a96573e49c83"},{"access_level":"open_access","file_name":"Supplfig01_a_4.tif","creator":"jdanzl","content_type":"image/tiff","file_size":723221,"file_id":"13694","relation":"main_file","success":1,"checksum":"e71faa54934bee8ac3e66ce692f542ab","date_created":"2023-08-03T13:21:35Z","date_updated":"2023-08-03T13:21:35Z"},{"content_type":"image/tiff","file_size":723235,"creator":"jdanzl","file_name":"Supplfig01_a_5.tif","access_level":"open_access","date_created":"2023-08-03T13:21:35Z","date_updated":"2023-08-03T13:21:35Z","checksum":"95dc33563f48b650e5ac020bdfd10c48","success":1,"relation":"main_file","file_id":"13695"},{"file_name":"Supplfig01_b_1.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":1442129,"file_id":"13696","relation":"main_file","date_created":"2023-08-03T13:21:35Z","date_updated":"2023-08-03T13:21:35Z","success":1,"checksum":"c62df0a9faf1c47af121d77eb1582edd"},{"file_id":"13697","relation":"main_file","date_created":"2023-08-03T13:21:35Z","date_updated":"2023-08-03T13:21:35Z","success":1,"checksum":"8ae157c5a4a543da1193cb8ca12b1919","file_name":"Supplfig01_b_2.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":725407},{"access_level":"open_access","file_name":"Supplfig01_c_1.tif","creator":"jdanzl","file_size":721641,"content_type":"image/tiff","file_id":"13698","relation":"main_file","success":1,"checksum":"388370d954ce842781c0d62edfb448a7","date_created":"2023-08-03T13:21:35Z","date_updated":"2023-08-03T13:21:35Z"},{"file_name":"Supplfig01_c_2.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":6003079,"file_id":"13699","relation":"main_file","date_created":"2023-08-03T13:21:35Z","date_updated":"2023-08-03T13:21:35Z","success":1,"checksum":"6cae58ba3c98bc8253e1c769e93657a7"},{"file_name":"Supplfig01_c_3.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":2003311,"file_id":"13700","relation":"main_file","date_updated":"2023-08-03T13:21:35Z","date_created":"2023-08-03T13:21:35Z","success":1,"checksum":"85cf013232c72895aefc07f5411a765a"},{"content_type":"image/tiff","file_size":723271,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig01_c_4.tif","checksum":"dfb33b91066e3f34d3803f59a4105aba","success":1,"date_created":"2023-08-03T13:21:35Z","date_updated":"2023-08-03T13:21:35Z","relation":"main_file","file_id":"13701"},{"access_level":"open_access","file_name":"Supplfig01_d_1.tif","creator":"jdanzl","content_type":"image/tiff","file_size":721901,"file_id":"13702","relation":"main_file","success":1,"checksum":"8b899826fe48d7e7536b0b02a2645e87","date_updated":"2023-08-03T13:21:35Z","date_created":"2023-08-03T13:21:35Z"},{"file_name":"Supplfig01_d_2.tif","access_level":"open_access","creator":"jdanzl","file_size":721901,"content_type":"image/tiff","file_id":"13703","relation":"main_file","date_updated":"2023-08-03T13:21:35Z","date_created":"2023-08-03T13:21:35Z","success":1,"checksum":"67529fa6e0f12c272275e823f6045f6d"},{"date_updated":"2023-08-03T13:21:35Z","date_created":"2023-08-03T13:21:35Z","success":1,"checksum":"111a9231f63c775340d3356109715cb0","file_id":"13704","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":723223,"file_name":"Supplfig01_e_1.tif","access_level":"open_access"},{"checksum":"7685bf02408dcb095a00854ff22763ed","success":1,"date_updated":"2023-08-03T13:21:35Z","date_created":"2023-08-03T13:21:35Z","relation":"main_file","file_id":"13705","file_size":723223,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Supplfig01_e_2.tif"},{"content_type":"image/tiff","file_size":34821298,"creator":"jdanzl","file_name":"Supplfig02_b_01.tif","access_level":"open_access","date_updated":"2023-08-03T13:26:00Z","date_created":"2023-08-03T13:26:00Z","checksum":"455f5cb9aa8a87b91586a27aca122610","success":1,"relation":"main_file","file_id":"13706"},{"success":1,"checksum":"311545b39aaa2c72755fd8ae190803a5","date_updated":"2023-08-03T13:26:00Z","date_created":"2023-08-03T13:26:00Z","file_id":"13707","relation":"main_file","creator":"jdanzl","file_size":32131123,"content_type":"image/tiff","access_level":"open_access","file_name":"Supplfig02_b_02.tif"},{"file_id":"13708","relation":"main_file","date_created":"2023-08-03T13:26:01Z","date_updated":"2023-08-03T13:26:01Z","success":1,"checksum":"682deb61f57d9ca54716160ddd52a6cf","file_name":"Supplfig02_b_03.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":36872674},{"content_type":"image/tiff","file_size":39964115,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig02_b_04.tif","checksum":"4f9579c91b2a3f36ff6e66b592907973","success":1,"date_updated":"2023-08-03T13:26:01Z","date_created":"2023-08-03T13:26:01Z","relation":"main_file","file_id":"13709"},{"relation":"main_file","file_id":"13710","checksum":"7ae7053673b53dbed59ffb92618f969a","success":1,"date_updated":"2023-08-03T13:26:02Z","date_created":"2023-08-03T13:26:02Z","access_level":"open_access","file_name":"Supplfig02_b_05.tif","content_type":"image/tiff","file_size":43053091,"creator":"jdanzl"},{"creator":"jdanzl","content_type":"image/tiff","file_size":46998147,"file_name":"Supplfig02_b_06.tif","access_level":"open_access","date_updated":"2023-08-03T13:26:02Z","date_created":"2023-08-03T13:26:02Z","success":1,"checksum":"827b26d3d2b6ddc9bced9d6113023ced","file_id":"13711","relation":"main_file"},{"file_id":"13712","relation":"main_file","date_updated":"2023-08-03T13:26:03Z","date_created":"2023-08-03T13:26:03Z","success":1,"checksum":"bc2e7e8badb42f8e1facc8b7bc96fdda","file_name":"Supplfig02_b_07.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":45179219},{"creator":"jdanzl","content_type":"image/tiff","file_size":46978802,"access_level":"open_access","file_name":"Supplfig02_b_08.tif","success":1,"checksum":"c2b78aa0f433928afa10a743c5fb73b8","date_updated":"2023-08-03T13:26:03Z","date_created":"2023-08-03T13:26:03Z","file_id":"13713","relation":"main_file"},{"file_id":"13714","relation":"main_file","success":1,"checksum":"9cd1ab61cced2c0981e813aeae930855","date_created":"2023-08-03T13:26:04Z","date_updated":"2023-08-03T13:26:04Z","access_level":"open_access","file_name":"Supplfig02_b_09.tif","creator":"jdanzl","file_size":48840915,"content_type":"image/tiff"},{"file_name":"Supplfig02_b_10.tif","access_level":"open_access","file_size":45907059,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13715","date_updated":"2023-08-03T13:26:04Z","date_created":"2023-08-03T13:26:04Z","checksum":"3086126338aee6ec4ebc1d3350551197","success":1},{"file_name":"Supplfig02_b_11.tif","access_level":"open_access","content_type":"image/tiff","file_size":32231538,"creator":"jdanzl","relation":"main_file","file_id":"13716","date_updated":"2023-08-03T13:26:05Z","date_created":"2023-08-03T13:26:05Z","checksum":"69f52c2b3bb5b5f9fef057860b3386fa","success":1},{"creator":"jdanzl","file_size":35264963,"content_type":"image/tiff","access_level":"open_access","file_name":"Supplfig02_b_12.tif","success":1,"checksum":"defdbeab1e672456bfeafdd1983e779e","date_updated":"2023-08-03T13:26:05Z","date_created":"2023-08-03T13:26:05Z","file_id":"13717","relation":"main_file"},{"file_name":"Supplfig03_a_std_xy.png","access_level":"open_access","file_size":63326,"content_type":"image/png","creator":"jdanzl","relation":"main_file","file_id":"13718","date_created":"2023-08-03T13:28:40Z","date_updated":"2023-08-03T13:28:40Z","checksum":"02c566f781b9ad44f04ce0088a1fa27a","success":1},{"file_id":"13719","relation":"main_file","success":1,"checksum":"c6c3630ee9a6ed5d207cb68e330da566","date_updated":"2023-08-03T13:28:40Z","date_created":"2023-08-03T13:28:40Z","access_level":"open_access","file_name":"Supplfig03_a_std_xz.png","creator":"jdanzl","content_type":"image/png","file_size":50211},{"success":1,"checksum":"0dcd4d19e83a7ff259d6aa04d746cd90","date_updated":"2023-08-03T13:28:41Z","date_created":"2023-08-03T13:28:41Z","file_id":"13720","relation":"main_file","creator":"jdanzl","content_type":"image/png","file_size":52629,"access_level":"open_access","file_name":"Supplfig03_b_std_xy.png"},{"file_name":"Supplfig03_b_std_xz.png","access_level":"open_access","content_type":"image/png","file_size":72245,"creator":"jdanzl","relation":"main_file","file_id":"13721","date_updated":"2023-08-03T13:28:41Z","date_created":"2023-08-03T13:28:41Z","checksum":"4785de4a6dcb23b25a06b0da29df5bb5","success":1},{"creator":"jdanzl","file_size":98570368,"content_type":"image/tiff","file_name":"Supplfig03_model1.tif","access_level":"open_access","date_updated":"2023-08-03T13:28:45Z","date_created":"2023-08-03T13:28:45Z","success":1,"checksum":"19d0f198bd8a25073e45e7950d7a78c2","file_id":"13722","relation":"main_file"},{"access_level":"open_access","file_name":"Supplfig03_model2.tif","content_type":"image/tiff","file_size":98570367,"creator":"jdanzl","relation":"main_file","file_id":"13723","checksum":"51ff687df4a0867f39b69c2c7a4ee3ca","success":1,"date_created":"2023-08-03T13:28:45Z","date_updated":"2023-08-03T13:28:45Z"},{"relation":"main_file","file_id":"13724","checksum":"ec9d9a041ca85fe632c612baf981fcc5","success":1,"date_updated":"2023-08-03T13:28:49Z","date_created":"2023-08-03T13:28:49Z","access_level":"open_access","file_name":"Supplfig03_model3.tif","file_size":98570365,"content_type":"image/tiff","creator":"jdanzl"},{"access_level":"open_access","file_name":"Supplfig03_model4.tif","creator":"jdanzl","content_type":"image/tiff","file_size":98570365,"file_id":"13725","relation":"main_file","success":1,"checksum":"a988b15a9529094f1b5519a72871e98e","date_updated":"2023-08-03T13:28:49Z","date_created":"2023-08-03T13:28:49Z"},{"creator":"jdanzl","content_type":"image/tiff","file_size":98570369,"access_level":"open_access","file_name":"Supplfig03_model5.tif","success":1,"checksum":"4a4fe88fcfd87fcfe118a5a73d81d6b0","date_updated":"2023-08-03T13:28:52Z","date_created":"2023-08-03T13:28:52Z","file_id":"13726","relation":"main_file"},{"file_size":1036927887,"content_type":"image/tiff","creator":"jdanzl","file_name":"Supplfig04_a_n2v.tif","access_level":"open_access","date_created":"2023-08-03T13:34:27Z","date_updated":"2023-08-03T13:34:27Z","checksum":"ce9b774ff5163ebfa4e3fb162f4cfffe","success":1,"relation":"main_file","file_id":"13727"},{"access_level":"open_access","file_name":"Supplfig04_a.tif","creator":"jdanzl","file_size":518519275,"content_type":"image/tiff","file_id":"13728","relation":"main_file","success":1,"checksum":"21f1bb8d2a00c88bdd6febe6285acc2a","date_updated":"2023-08-03T13:34:13Z","date_created":"2023-08-03T13:34:13Z"},{"date_created":"2023-08-03T13:34:22Z","date_updated":"2023-08-03T13:34:22Z","checksum":"503820214ab994c01b18a241f3b62434","success":1,"relation":"main_file","file_id":"13729","file_size":158440069,"content_type":"image/tiff","creator":"jdanzl","file_name":"Supplfig04_b.tif","access_level":"open_access"},{"date_created":"2023-08-03T13:34:37Z","date_updated":"2023-08-03T13:34:37Z","checksum":"e0469102a87332b46904b4ba35b8fb2f","success":1,"relation":"main_file","file_id":"13730","file_size":309407894,"content_type":"image/tiff","creator":"jdanzl","file_name":"Supplfig04_c_n2v.tif","access_level":"open_access"},{"checksum":"c30a0d18c43045a8fbc5501a37061bd2","success":1,"date_updated":"2023-08-03T13:34:38Z","date_created":"2023-08-03T13:34:38Z","relation":"main_file","file_id":"13731","content_type":"image/tiff","file_size":154728887,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig04_c.tif"},{"checksum":"69c706710d642b30cda6951494702139","success":1,"date_created":"2023-08-03T13:34:43Z","date_updated":"2023-08-03T13:34:43Z","relation":"main_file","file_id":"13732","file_size":106696749,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Supplfig04_d_n2v.tif"},{"file_id":"13733","relation":"main_file","date_created":"2023-08-03T13:34:41Z","date_updated":"2023-08-03T13:34:41Z","success":1,"checksum":"7dbd2e881ebf049352913188fa10224a","file_name":"Supplfig04_d.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":53367343},{"date_updated":"2023-08-03T13:34:46Z","date_created":"2023-08-03T13:34:46Z","checksum":"fd0d1ec674dabbb499fab383b7eb4d58","success":1,"relation":"main_file","file_id":"13734","file_size":127917734,"content_type":"image/tiff","creator":"jdanzl","file_name":"Supplfig04_e_n2v.tiff","access_level":"open_access"},{"relation":"main_file","file_id":"13735","checksum":"86de309d9cd434afbe371da283d8adb6","success":1,"date_created":"2023-08-03T13:34:46Z","date_updated":"2023-08-03T13:34:46Z","access_level":"open_access","file_name":"Supplfig04_e.tif","file_size":63974204,"content_type":"image/tiff","creator":"jdanzl"},{"relation":"main_file","file_id":"13736","checksum":"ada99b2b5900cb198d1de3cc9e37ebd1","success":1,"date_updated":"2023-08-03T13:35:37Z","date_created":"2023-08-03T13:35:37Z","access_level":"open_access","file_name":"Supplfig05_a_xy_1.png","content_type":"image/png","file_size":8403,"creator":"jdanzl"},{"access_level":"open_access","file_name":"Supplfig05_a_xy_2.png","content_type":"image/png","file_size":10087,"creator":"jdanzl","relation":"main_file","file_id":"13737","checksum":"f2e382925a972b98560614016ae3bc55","success":1,"date_updated":"2023-08-03T13:35:37Z","date_created":"2023-08-03T13:35:37Z"},{"success":1,"checksum":"ef22b640f33d677add1a7b5153f95420","date_created":"2023-08-03T13:35:37Z","date_updated":"2023-08-03T13:35:37Z","file_id":"13738","relation":"main_file","creator":"jdanzl","file_size":24561,"content_type":"image/png","access_level":"open_access","file_name":"Supplfig05_a_xy_3.png"},{"access_level":"open_access","file_name":"Supplfig05_a_xy_4.png","file_size":8353,"content_type":"image/png","creator":"jdanzl","relation":"main_file","file_id":"13739","checksum":"b854cc4a5224b8a6f5d59c74f5740ccd","success":1,"date_updated":"2023-08-03T13:35:37Z","date_created":"2023-08-03T13:35:37Z"},{"file_name":"Supplfig05_a_xy_5.png","access_level":"open_access","content_type":"image/png","file_size":8337,"creator":"jdanzl","relation":"main_file","file_id":"13740","date_created":"2023-08-03T13:35:37Z","date_updated":"2023-08-03T13:35:37Z","checksum":"446b0362c5ea6e2a5f0e1f8359422358","success":1},{"file_size":7399,"content_type":"image/png","creator":"jdanzl","file_name":"Supplfig05_a_xz_1.png","access_level":"open_access","date_updated":"2023-08-03T13:35:37Z","date_created":"2023-08-03T13:35:37Z","checksum":"5585f7b62fa09ed5a63090b679383601","success":1,"relation":"main_file","file_id":"13741"},{"date_updated":"2023-08-03T13:35:37Z","date_created":"2023-08-03T13:35:37Z","checksum":"190d88bcacbd11d41f4a0e2bbd140862","success":1,"relation":"main_file","file_id":"13742","file_size":10887,"content_type":"image/png","creator":"jdanzl","file_name":"Supplfig05_a_xz_2.png","access_level":"open_access"},{"date_created":"2023-08-03T13:35:37Z","date_updated":"2023-08-03T13:35:37Z","success":1,"checksum":"0c89010651862f21032a303e159b7a1c","file_id":"13743","relation":"main_file","creator":"jdanzl","content_type":"image/png","file_size":21654,"file_name":"Supplfig05_a_xz_3.png","access_level":"open_access"},{"content_type":"image/png","file_size":7248,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig05_a_xz_4.png","checksum":"94e61e553aa2280721acce7d407ff24a","success":1,"date_updated":"2023-08-03T13:35:37Z","date_created":"2023-08-03T13:35:37Z","relation":"main_file","file_id":"13744"},{"file_size":7214,"content_type":"image/png","creator":"jdanzl","file_name":"Supplfig05_a_xz_5.png","access_level":"open_access","date_updated":"2023-08-03T13:35:37Z","date_created":"2023-08-03T13:35:37Z","checksum":"ef9157274686ff5d7056f5a519d413dd","success":1,"relation":"main_file","file_id":"13745"},{"file_name":"Supplfig05_b_xy_1.png","access_level":"open_access","file_size":8544,"content_type":"image/png","creator":"jdanzl","relation":"main_file","file_id":"13746","date_created":"2023-08-03T13:35:37Z","date_updated":"2023-08-03T13:35:37Z","checksum":"4b389473cbf769e6e34670dae2224af1","success":1},{"relation":"main_file","file_id":"13747","checksum":"b05aa1e201758a5d55e35d719452fafc","success":1,"date_updated":"2023-08-03T13:35:37Z","date_created":"2023-08-03T13:35:37Z","access_level":"open_access","file_name":"Supplfig05_b_xy_2.png","file_size":11135,"content_type":"image/png","creator":"jdanzl"},{"file_name":"Supplfig05_b_xy_3.png","access_level":"open_access","content_type":"image/png","file_size":26762,"creator":"jdanzl","relation":"main_file","file_id":"13748","date_updated":"2023-08-03T13:35:37Z","date_created":"2023-08-03T13:35:37Z","checksum":"890f3516930251a367066c049141d6bb","success":1},{"checksum":"36345c1d582758ff463072fd04578c0c","success":1,"date_created":"2023-08-03T13:35:37Z","date_updated":"2023-08-03T13:35:37Z","relation":"main_file","file_id":"13749","content_type":"image/png","file_size":8438,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig05_b_xy_4.png"},{"checksum":"c9499ad8914c405a07fc4469b19e8987","success":1,"date_created":"2023-08-03T13:35:37Z","date_updated":"2023-08-03T13:35:37Z","relation":"main_file","file_id":"13750","content_type":"image/png","file_size":8434,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig05_b_xy_5.png"},{"access_level":"open_access","file_name":"Supplfig05_b_xz_1.png","creator":"jdanzl","content_type":"image/png","file_size":8269,"file_id":"13751","relation":"main_file","success":1,"checksum":"7e7a7c900ce1fc3187ab648f207f9425","date_updated":"2023-08-03T13:35:37Z","date_created":"2023-08-03T13:35:37Z"},{"success":1,"checksum":"b645d1e2422ef3f05344ccd3f955468d","date_created":"2023-08-03T13:35:37Z","date_updated":"2023-08-03T13:35:37Z","file_id":"13752","relation":"main_file","creator":"jdanzl","file_size":12762,"content_type":"image/png","access_level":"open_access","file_name":"Supplfig05_b_xz_2.png"},{"content_type":"image/png","file_size":24819,"creator":"jdanzl","file_name":"Supplfig05_b_xz_3.png","access_level":"open_access","date_updated":"2023-08-03T13:35:37Z","date_created":"2023-08-03T13:35:37Z","checksum":"ef0b83b49cf47ca7d8ffe3bdc609fe38","success":1,"relation":"main_file","file_id":"13753"},{"creator":"jdanzl","file_size":8126,"content_type":"image/png","access_level":"open_access","file_name":"Supplfig05_b_xz_4.png","success":1,"checksum":"68719d4d464a2ffc198cb6ad070c4579","date_created":"2023-08-03T13:35:37Z","date_updated":"2023-08-03T13:35:37Z","file_id":"13754","relation":"main_file"},{"file_size":8114,"content_type":"image/png","creator":"jdanzl","access_level":"open_access","file_name":"Supplfig05_b_xz_5.png","checksum":"18370f47177ef37a477c6fd7bda3fea0","success":1,"date_created":"2023-08-03T13:35:38Z","date_updated":"2023-08-03T13:35:38Z","relation":"main_file","file_id":"13755"},{"file_name":"Supplfig05_c_xy_1.png","access_level":"open_access","file_size":8273,"content_type":"image/png","creator":"jdanzl","relation":"main_file","file_id":"13756","date_created":"2023-08-03T13:35:38Z","date_updated":"2023-08-03T13:35:38Z","checksum":"013d4bd9704ace490810b9ef21b12454","success":1},{"access_level":"open_access","file_name":"Supplfig05_c_xy_2.png","file_size":12639,"content_type":"image/png","creator":"jdanzl","relation":"main_file","file_id":"13757","checksum":"bb431f827386e79c54452d6284f501b9","success":1,"date_updated":"2023-08-03T13:35:38Z","date_created":"2023-08-03T13:35:38Z"},{"creator":"jdanzl","content_type":"image/png","file_size":25288,"access_level":"open_access","file_name":"Supplfig05_c_xy_3.png","success":1,"checksum":"4cd54f58c5afff88832a508655f913bb","date_created":"2023-08-03T13:35:38Z","date_updated":"2023-08-03T13:35:38Z","file_id":"13758","relation":"main_file"},{"date_updated":"2023-08-03T13:35:38Z","date_created":"2023-08-03T13:35:38Z","checksum":"07f86f98f6a65eac8608cec8c567309e","success":1,"relation":"main_file","file_id":"13759","content_type":"image/png","file_size":6786,"creator":"jdanzl","file_name":"Supplfig05_c_xz_1.png","access_level":"open_access"},{"file_name":"Supplfig05_c_xz_2.png","access_level":"open_access","file_size":9781,"content_type":"image/png","creator":"jdanzl","relation":"main_file","file_id":"13760","date_created":"2023-08-03T13:35:38Z","date_updated":"2023-08-03T13:35:38Z","checksum":"492f699b71761214272b17432e3a54fa","success":1},{"access_level":"open_access","file_name":"Supplfig05_c_xz_3.png","content_type":"image/png","file_size":20728,"creator":"jdanzl","relation":"main_file","file_id":"13761","checksum":"af617da5638db849bea6ff51a08227c6","success":1,"date_created":"2023-08-03T13:35:38Z","date_updated":"2023-08-03T13:35:38Z"},{"access_level":"open_access","file_name":"Supplfig05_d_xy_1.png","creator":"jdanzl","content_type":"image/png","file_size":8428,"file_id":"13762","relation":"main_file","success":1,"checksum":"5e5d5694af4a22297046d697a01fa4d6","date_created":"2023-08-03T13:35:38Z","date_updated":"2023-08-03T13:35:38Z"},{"access_level":"open_access","file_name":"Supplfig05_d_xy_2.png","creator":"jdanzl","content_type":"image/png","file_size":10813,"file_id":"13763","relation":"main_file","success":1,"checksum":"38bf7b75f3dedd0a3722faae05aa0233","date_updated":"2023-08-03T13:35:38Z","date_created":"2023-08-03T13:35:38Z"},{"file_name":"Supplfig05_d_xy_3.png","access_level":"open_access","file_size":26552,"content_type":"image/png","creator":"jdanzl","relation":"main_file","file_id":"13764","date_updated":"2023-08-03T13:35:38Z","date_created":"2023-08-03T13:35:38Z","checksum":"e4ea966553f158ec2cfbdc696780390e","success":1},{"file_id":"13765","relation":"main_file","success":1,"checksum":"356f424d9f5f608e9aea962bb63672f1","date_created":"2023-08-03T13:35:38Z","date_updated":"2023-08-03T13:35:38Z","access_level":"open_access","file_name":"Supplfig05_d_xz_1.png","creator":"jdanzl","content_type":"image/png","file_size":7876},{"success":1,"checksum":"05068476beee0f394e28b98209686394","date_updated":"2023-08-03T13:35:38Z","date_created":"2023-08-03T13:35:38Z","file_id":"13766","relation":"main_file","creator":"jdanzl","content_type":"image/png","file_size":11634,"access_level":"open_access","file_name":"Supplfig05_d_xz_2.png"},{"file_id":"13767","relation":"main_file","success":1,"checksum":"78b3a0d93df22383a384a2f3acc80401","date_created":"2023-08-03T13:35:38Z","date_updated":"2023-08-03T13:35:38Z","access_level":"open_access","file_name":"Supplfig05_d_xz_3.png","creator":"jdanzl","file_size":25006,"content_type":"image/png"},{"content_type":"image/png","file_size":7895,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig05_e_xy_1.png","checksum":"f5ee6a817f11a42c9db82ad6325f58b9","success":1,"date_created":"2023-08-03T13:35:38Z","date_updated":"2023-08-03T13:35:38Z","relation":"main_file","file_id":"13768"},{"relation":"main_file","file_id":"13769","checksum":"019ca89e892d6e19589609bc99eab331","success":1,"date_created":"2023-08-03T13:35:38Z","date_updated":"2023-08-03T13:35:38Z","access_level":"open_access","file_name":"Supplfig05_e_xy_2.png","content_type":"image/png","file_size":6180,"creator":"jdanzl"},{"success":1,"checksum":"0e1a5cbbd70dc245edaecaca70d974cb","date_created":"2023-08-03T13:35:38Z","date_updated":"2023-08-03T13:35:38Z","file_id":"13770","relation":"main_file","creator":"jdanzl","file_size":18326,"content_type":"image/png","access_level":"open_access","file_name":"Supplfig05_e_xy_3.png"},{"creator":"jdanzl","file_size":6295,"content_type":"image/png","access_level":"open_access","file_name":"Supplfig05_e_xz_1.png","success":1,"checksum":"4d4d64a5bb7b096aaf8130ece4512bc2","date_created":"2023-08-03T13:35:38Z","date_updated":"2023-08-03T13:35:38Z","file_id":"13771","relation":"main_file"},{"relation":"main_file","file_id":"13772","date_updated":"2023-08-03T13:35:38Z","date_created":"2023-08-03T13:35:38Z","checksum":"607302aec5ec2a14a271dbffd3465261","success":1,"file_name":"Supplfig05_e_xz_2.png","access_level":"open_access","content_type":"image/png","file_size":4335,"creator":"jdanzl"},{"relation":"main_file","file_id":"13773","checksum":"a673e17ead1fd2e776b9a5f560a289ab","success":1,"date_created":"2023-08-03T13:35:38Z","date_updated":"2023-08-03T13:35:38Z","access_level":"open_access","file_name":"Supplfig05_e_xz_3.png","content_type":"image/png","file_size":23243,"creator":"jdanzl"},{"date_updated":"2023-08-03T13:46:13Z","date_created":"2023-08-03T13:46:13Z","checksum":"4349e511fc86a8bddb790a7be7175c75","success":1,"relation":"main_file","file_id":"13774","file_size":4002153,"content_type":"image/tiff","creator":"jdanzl","file_name":"Supplfig06_a_1.tif","access_level":"open_access"},{"file_name":"Supplfig06_a_2.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":2252137,"file_id":"13775","relation":"main_file","date_created":"2023-08-03T13:46:13Z","date_updated":"2023-08-03T13:46:13Z","success":1,"checksum":"cd12977e4c1a472d80193be01f69a895"},{"access_level":"open_access","file_name":"Supplfig06_a_3.tif","file_size":2252137,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13776","checksum":"575e32b8c25ce658e20f0c86a5f1b9b7","success":1,"date_updated":"2023-08-03T13:46:13Z","date_created":"2023-08-03T13:46:13Z"},{"relation":"main_file","file_id":"13777","date_updated":"2023-08-03T13:46:13Z","date_created":"2023-08-03T13:46:13Z","checksum":"b06f775e0210e7a16cb4b58aed32118c","success":1,"file_name":"Supplfig06_a_i.tif","access_level":"open_access","file_size":78329,"content_type":"image/tiff","creator":"jdanzl"},{"checksum":"56854c1a05c721c36877fe7c7454b7d7","success":1,"date_created":"2023-08-03T13:46:13Z","date_updated":"2023-08-03T13:46:13Z","relation":"main_file","file_id":"13778","content_type":"image/tiff","file_size":78329,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig06_a_ii.tif"},{"file_size":78329,"content_type":"image/tiff","creator":"jdanzl","file_name":"Supplfig06_a_iii.tif","access_level":"open_access","date_created":"2023-08-03T13:46:13Z","date_updated":"2023-08-03T13:46:13Z","checksum":"9aff42ea5138931fedb5a00643ae7a22","success":1,"relation":"main_file","file_id":"13779"},{"file_name":"Supplfig06_d_1.tif","access_level":"open_access","file_size":501149,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13780","date_created":"2023-08-03T13:46:13Z","date_updated":"2023-08-03T13:46:13Z","checksum":"9474b7d00d4dee46659afedef75dc095","success":1},{"creator":"jdanzl","file_size":500153,"content_type":"image/tiff","access_level":"open_access","file_name":"Supplfig06_d_2.tif","success":1,"checksum":"53df41dd968b04b4657cd2b91870d636","date_created":"2023-08-03T13:46:13Z","date_updated":"2023-08-03T13:46:13Z","file_id":"13781","relation":"main_file"},{"checksum":"1a39b8310598dd25d97f848b682b8de0","success":1,"date_updated":"2023-08-03T13:46:14Z","date_created":"2023-08-03T13:46:14Z","relation":"main_file","file_id":"13782","file_size":500153,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Supplfig06_d_3.tif"},{"content_type":"image/tiff","file_size":78329,"creator":"jdanzl","file_name":"Supplfig06_d_i.tif","access_level":"open_access","date_created":"2023-08-03T13:46:14Z","date_updated":"2023-08-03T13:46:14Z","checksum":"6d9b496be6aecedbb2cb4cbf68f02872","success":1,"relation":"main_file","file_id":"13783"},{"relation":"main_file","file_id":"13784","date_created":"2023-08-03T13:46:14Z","date_updated":"2023-08-03T13:46:14Z","checksum":"bc034b1636c2db8b9d9e7bd131b9780a","success":1,"file_name":"Supplfig06_d_ii.tif","access_level":"open_access","file_size":78329,"content_type":"image/tiff","creator":"jdanzl"},{"file_name":"Supplfig06_d_iii.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":78329,"file_id":"13785","relation":"main_file","date_updated":"2023-08-03T13:46:14Z","date_created":"2023-08-03T13:46:14Z","success":1,"checksum":"54f6e55e30a2aeea6c82eb6dbd376240"},{"relation":"main_file","file_id":"13786","checksum":"446da3cc16897277890f23f966c2bf52","success":1,"date_updated":"2023-08-03T13:46:14Z","date_created":"2023-08-03T13:46:14Z","access_level":"open_access","file_name":"Supplfig06_g_1.tif","file_size":960011,"content_type":"image/tiff","creator":"jdanzl"},{"content_type":"image/tiff","file_size":960011,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig06_g_2.tif","checksum":"71192d0ec592a33195f2386a5f95aa86","success":1,"date_updated":"2023-08-03T13:46:14Z","date_created":"2023-08-03T13:46:14Z","relation":"main_file","file_id":"13787"},{"date_created":"2023-08-03T13:46:14Z","date_updated":"2023-08-03T13:46:14Z","success":1,"checksum":"246782dbe8ff525aea360efc72e65f07","file_id":"13788","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":960041,"file_name":"Supplfig06_g_3.tif","access_level":"open_access"},{"file_name":"Supplfig06_g_4.tif","access_level":"open_access","content_type":"image/tiff","file_size":960041,"creator":"jdanzl","relation":"main_file","file_id":"13789","date_updated":"2023-08-03T13:46:14Z","date_created":"2023-08-03T13:46:14Z","checksum":"d49b12fec5508aa8d72587757cccc0a4","success":1},{"access_level":"open_access","file_name":"Supplfig06_g_5.tif","content_type":"image/tiff","file_size":963241,"creator":"jdanzl","relation":"main_file","file_id":"13790","checksum":"27b11b1d4fc784a49ffd7660624d00b6","success":1,"date_created":"2023-08-03T13:46:14Z","date_updated":"2023-08-03T13:46:14Z"},{"date_updated":"2023-08-03T13:51:38Z","date_created":"2023-08-03T13:51:38Z","checksum":"9ce944049c1b88fadbf43609385f9e2f","success":1,"relation":"main_file","file_id":"13791","file_size":19286002,"content_type":"image/tiff","creator":"jdanzl","file_name":"Suppl08_a_1.tiff","access_level":"open_access"},{"relation":"main_file","file_id":"13792","date_created":"2023-08-03T13:51:38Z","date_updated":"2023-08-03T13:51:38Z","checksum":"06265515f06688843a415362f7b2c485","success":1,"file_name":"Suppl08_a_2.tiff","access_level":"open_access","content_type":"image/tiff","file_size":19286002,"creator":"jdanzl"},{"access_level":"open_access","file_name":"Suppl08_a_3.tif","content_type":"image/tiff","file_size":617552,"creator":"jdanzl","relation":"main_file","file_id":"13793","checksum":"50f0969c6c2c1209ff776bec4861030a","success":1,"date_created":"2023-08-03T13:51:38Z","date_updated":"2023-08-03T13:51:38Z"},{"checksum":"b90965d20133fea73c99050c32eb7695","success":1,"date_created":"2023-08-03T13:51:38Z","date_updated":"2023-08-03T13:51:38Z","relation":"main_file","file_id":"13794","content_type":"image/tiff","file_size":617552,"creator":"jdanzl","access_level":"open_access","file_name":"Suppl08_a_4.tif"},{"file_id":"13795","relation":"main_file","date_updated":"2023-08-03T13:51:40Z","date_created":"2023-08-03T13:51:40Z","success":1,"checksum":"568a1e0efaa62527b51e66a7aabfd05c","file_name":"Suppl08_a_coCATS_N2V.tif","access_level":"open_access","creator":"jdanzl","file_size":19287339,"content_type":"image/tiff"},{"checksum":"06265515f06688843a415362f7b2c485","success":1,"date_updated":"2023-08-03T13:51:40Z","date_created":"2023-08-03T13:51:40Z","relation":"main_file","file_id":"13796","content_type":"image/tiff","file_size":19286002,"creator":"jdanzl","access_level":"open_access","file_name":"Suppl08_c_1_4_predictedBASSOON.tiff"},{"file_id":"13797","relation":"main_file","date_updated":"2023-08-03T13:51:43Z","date_created":"2023-08-03T13:51:43Z","success":1,"checksum":"568a1e0efaa62527b51e66a7aabfd05c","file_name":"Suppl08_c_1_coCATS.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":19287339},{"date_created":"2023-08-03T15:36:47Z","date_updated":"2023-08-03T15:36:47Z","checksum":"feae08c38b1d9c540b697977cd7f2666","success":1,"relation":"main_file","file_id":"13798","content_type":"image/tiff","file_size":19287340,"creator":"jdanzl","file_name":"Suppl08_c_2_coCATS.tif","access_level":"open_access"},{"file_name":"Suppl08_c_2-3_predictedBASSOON.tiff","access_level":"open_access","content_type":"image/tiff","file_size":19286002,"creator":"jdanzl","relation":"main_file","file_id":"13799","date_updated":"2023-08-03T13:51:44Z","date_created":"2023-08-03T13:51:44Z","checksum":"af2c1199fdcaecfec76189dae86cc12e","success":1},{"file_size":156,"content_type":"application/octet-stream","creator":"jdanzl","access_level":"open_access","file_name":"Suppl08_c_3-6_roi.roi","checksum":"1f92db47605959d0db01f612f7c9c034","success":1,"date_created":"2023-08-03T13:51:43Z","date_updated":"2023-08-03T13:51:43Z","relation":"main_file","file_id":"13800"},{"access_level":"open_access","file_name":"Suppl08_e_1_3.tiff","creator":"jdanzl","file_size":19286002,"content_type":"image/tiff","file_id":"13801","relation":"main_file","success":1,"checksum":"4fc4f8803adcfacd53a41b91f4699dc5","date_created":"2023-08-03T13:51:45Z","date_updated":"2023-08-03T13:51:45Z"},{"creator":"jdanzl","content_type":"image/tiff","file_size":19286002,"file_name":"Suppl08_e_1-2.tiff","access_level":"open_access","date_created":"2023-08-03T13:51:45Z","date_updated":"2023-08-03T13:51:45Z","success":1,"checksum":"459551aae114daa4f5ca5d06fcd6b203","file_id":"13802","relation":"main_file"},{"success":1,"checksum":"032cbace7ec436f7b62478c0ffd35e5e","date_updated":"2023-08-03T13:51:45Z","date_created":"2023-08-03T13:51:45Z","file_id":"13803","relation":"main_file","creator":"jdanzl","content_type":"application/octet-stream","file_size":152,"access_level":"open_access","file_name":"Suppl08_e_2-5_roi.roi"},{"relation":"main_file","file_id":"13804","date_created":"2023-08-03T13:51:46Z","date_updated":"2023-08-03T13:51:46Z","checksum":"7379168be281ef618b8cecd8efd31ed5","success":1,"file_name":"Suppl08_e_4-5_coCATS.tiff","access_level":"open_access","file_size":19286002,"content_type":"image/tiff","creator":"jdanzl"},{"access_level":"open_access","file_name":"Suppl08_e_4.tif","content_type":"image/tiff","file_size":617552,"creator":"jdanzl","relation":"main_file","file_id":"13805","checksum":"5c4c092f608f4c10bb422c9e08b5955b","success":1,"date_updated":"2023-08-03T13:51:46Z","date_created":"2023-08-03T13:51:46Z"},{"access_level":"open_access","file_name":"Suppl08_e_5.tif","file_size":617552,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13806","checksum":"903e31be124f6e4ec1c2e7ab7db80e6b","success":1,"date_created":"2023-08-03T13:51:46Z","date_updated":"2023-08-03T13:51:46Z"},{"file_id":"13807","relation":"main_file","success":1,"checksum":"173d956392d67b0a7e544629b51881e4","date_updated":"2023-08-03T13:51:48Z","date_created":"2023-08-03T13:51:48Z","access_level":"open_access","file_name":"Suppl08_e_6_8.tiff","creator":"jdanzl","file_size":19286002,"content_type":"image/tiff"},{"relation":"main_file","file_id":"13808","checksum":"2a4cea867a253a6af7e9b0d2e100de14","success":1,"date_updated":"2023-08-03T13:51:48Z","date_created":"2023-08-03T13:51:48Z","access_level":"open_access","file_name":"Suppl08_e_6-7.tiff","file_size":19286002,"content_type":"image/tiff","creator":"jdanzl"},{"checksum":"6b40f99fddfa26f0a9713000769741b7","success":1,"date_updated":"2023-08-03T13:51:48Z","date_created":"2023-08-03T13:51:48Z","relation":"main_file","file_id":"13809","file_size":174,"content_type":"application/octet-stream","creator":"jdanzl","access_level":"open_access","file_name":"Suppl08_e_7-10_roi.roi"},{"creator":"jdanzl","content_type":"image/tiff","file_size":19286002,"file_name":"Suppl08_e_9-10_coCATS.tiff","access_level":"open_access","date_updated":"2023-08-03T13:51:49Z","date_created":"2023-08-03T13:51:49Z","success":1,"checksum":"82f7013959df99c27366886de9b38ba2","file_id":"13810","relation":"main_file"},{"relation":"main_file","file_id":"13811","date_created":"2023-08-03T13:51:48Z","date_updated":"2023-08-03T13:51:48Z","checksum":"50f0969c6c2c1209ff776bec4861030a","success":1,"file_name":"Suppl08_e_9.tif","access_level":"open_access","content_type":"image/tiff","file_size":617552,"creator":"jdanzl"},{"file_size":617552,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Suppl08_e_10.tif","checksum":"569f599d7f2be49d4dcf7cb385f428c4","success":1,"date_created":"2023-08-03T13:51:49Z","date_updated":"2023-08-03T13:51:49Z","relation":"main_file","file_id":"13812"},{"access_level":"open_access","file_name":"Suppl08_g_1.tif","file_size":617552,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13813","checksum":"50f0969c6c2c1209ff776bec4861030a","success":1,"date_created":"2023-08-03T13:51:49Z","date_updated":"2023-08-03T13:51:49Z"},{"date_created":"2023-08-03T13:51:49Z","date_updated":"2023-08-03T13:51:49Z","checksum":"62797fc860176197142a47e831eaf1f6","success":1,"relation":"main_file","file_id":"13814","content_type":"image/tiff","file_size":617552,"creator":"jdanzl","file_name":"Suppl08_g_2.tif","access_level":"open_access"},{"creator":"jdanzl","content_type":"image/tiff","file_size":617552,"file_name":"Suppl08_g_3.tif","access_level":"open_access","date_created":"2023-08-03T13:51:49Z","date_updated":"2023-08-03T13:51:49Z","success":1,"checksum":"b90965d20133fea73c99050c32eb7695","file_id":"13815","relation":"main_file"},{"file_id":"13816","relation":"main_file","date_created":"2023-08-03T13:51:49Z","date_updated":"2023-08-03T13:51:49Z","success":1,"checksum":"a96dc9f38c6a1d3c959771a649a42748","file_name":"Suppl08_i_add_roi.roi","access_level":"open_access","creator":"jdanzl","content_type":"application/octet-stream","file_size":160},{"access_level":"open_access","file_name":"Suppl08_i_shape_roi.roi","creator":"jdanzl","file_size":160,"content_type":"application/octet-stream","file_id":"13817","relation":"main_file","success":1,"checksum":"f2135207ebbc4bdc014763ba852a5cf0","date_updated":"2023-08-03T13:51:50Z","date_created":"2023-08-03T13:51:50Z"},{"creator":"jdanzl","file_size":158,"content_type":"application/octet-stream","access_level":"open_access","file_name":"Suppl08_i_split_roi.roi","success":1,"checksum":"f6f31fe2d87cf7208387f98ce1e37b04","date_updated":"2023-08-03T13:51:50Z","date_created":"2023-08-03T13:51:50Z","file_id":"13818","relation":"main_file"},{"success":1,"checksum":"71590db0ad391e0c5baf03024981b1d9","date_created":"2023-08-03T13:51:51Z","date_updated":"2023-08-03T13:51:51Z","file_id":"13819","relation":"main_file","creator":"jdanzl","file_size":19286002,"content_type":"image/tiff","access_level":"open_access","file_name":"Suppl08_i_1.tiff"},{"relation":"main_file","file_id":"13820","checksum":"9ce944049c1b88fadbf43609385f9e2f","success":1,"date_updated":"2023-08-03T13:51:51Z","date_created":"2023-08-03T13:51:51Z","access_level":"open_access","file_name":"Suppl08_i_2.tiff","file_size":19286002,"content_type":"image/tiff","creator":"jdanzl"},{"relation":"main_file","file_id":"13821","checksum":"06265515f06688843a415362f7b2c485","success":1,"date_updated":"2023-08-03T13:51:52Z","date_created":"2023-08-03T13:51:52Z","access_level":"open_access","file_name":"Suppl08_i_3.tiff","content_type":"image/tiff","file_size":19286002,"creator":"jdanzl"},{"relation":"main_file","file_id":"13822","date_updated":"2023-08-03T13:51:52Z","date_created":"2023-08-03T13:51:52Z","checksum":"16c628c160fb81e40df0ad1eb134e92b","success":1,"file_name":"Suppl08_i_4.tif","access_level":"open_access","content_type":"image/tiff","file_size":19284766,"creator":"jdanzl"},{"checksum":"b06e62c3a9834a40002d7aad3eaacc3f","success":1,"date_updated":"2023-08-03T13:51:53Z","date_created":"2023-08-03T13:51:53Z","relation":"main_file","file_id":"13823","file_size":9649818,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Suppl08_i_5.tif"},{"content_type":"image/tiff","file_size":19284766,"creator":"jdanzl","access_level":"open_access","file_name":"Suppl08_i_6.tif","checksum":"41ef98c7f01755b43cf6e77fff287732","success":1,"date_created":"2023-08-03T13:51:53Z","date_updated":"2023-08-03T13:51:53Z","relation":"main_file","file_id":"13824"},{"content_type":"image/tiff","file_size":19287340,"creator":"jdanzl","file_name":"Suppl08_c_2_coCATS.tif","access_level":"open_access","date_created":"2023-08-03T13:53:29Z","date_updated":"2023-08-03T13:53:29Z","checksum":"feae08c38b1d9c540b697977cd7f2666","success":1,"relation":"main_file","file_id":"13825"},{"content_type":"image/tiff","file_size":179788642,"creator":"jdanzl","file_name":"Supplfig09_b_1_n2v.tiff","access_level":"open_access","date_updated":"2023-08-03T13:58:08Z","date_created":"2023-08-03T13:58:08Z","checksum":"c01509a1c657fbbbfdbbd484c298b6e3","success":1,"relation":"main_file","file_id":"13826"},{"file_id":"13827","relation":"main_file","success":1,"checksum":"64a7f270274ff3480b18d690087016e2","date_created":"2023-08-03T13:58:20Z","date_updated":"2023-08-03T13:58:20Z","access_level":"open_access","file_name":"Supplfig09_b_2_n2v.tif","creator":"jdanzl","content_type":"image/tiff","file_size":742420240},{"date_created":"2023-08-03T13:58:20Z","date_updated":"2023-08-03T13:58:20Z","success":1,"checksum":"b34a6beaaf13698f421df961e009efeb","file_id":"13828","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":478900363,"file_name":"Supplfig09_b_3_n2v.tif","access_level":"open_access"},{"content_type":"image/tiff","file_size":191873159,"creator":"jdanzl","file_name":"Supplfig09_b_4_n2v.tif","access_level":"open_access","date_updated":"2023-08-03T13:58:25Z","date_created":"2023-08-03T13:58:25Z","checksum":"ec04501f234b5e4fd91f9eac0e585395","success":1,"relation":"main_file","file_id":"13829"},{"date_created":"2023-08-03T13:59:27Z","date_updated":"2023-08-03T13:59:27Z","success":1,"checksum":"3a1b313298da35c97550abf0d245b4a7","file_id":"13830","relation":"main_file","creator":"jdanzl","file_size":55286,"content_type":"image/tiff","file_name":"Supplfig11_i.tif","access_level":"open_access"},{"file_size":55286,"content_type":"image/tiff","creator":"jdanzl","file_name":"Supplfig11_ii.tif","access_level":"open_access","date_updated":"2023-08-03T13:59:27Z","date_created":"2023-08-03T13:59:27Z","checksum":"9cf00c0252f0a2efe1994c83c224389a","success":1,"relation":"main_file","file_id":"13831"},{"creator":"jdanzl","content_type":"image/tiff","file_size":55257,"access_level":"open_access","file_name":"Supplfig11_iii.tif","success":1,"checksum":"9a6e83acdf6d70bb9a6e76fa7d41a372","date_created":"2023-08-03T13:59:27Z","date_updated":"2023-08-03T13:59:27Z","file_id":"13832","relation":"main_file"},{"relation":"main_file","file_id":"13833","checksum":"709fdd13b7e090846a4d8edd2425f675","success":1,"date_updated":"2023-08-03T13:59:32Z","date_created":"2023-08-03T13:59:32Z","access_level":"open_access","file_name":"Supplfig11_n2v+prediction.tif","file_size":309457551,"content_type":"image/tiff","creator":"jdanzl"},{"creator":"jdanzl","file_size":119323629,"content_type":"image/tiff","access_level":"open_access","file_name":"Supplfig12_a_01_n2v.tif","success":1,"checksum":"e60ea3e6bb1bf380460d0d8ccdbd1f07","date_updated":"2023-08-03T14:14:32Z","date_created":"2023-08-03T14:14:32Z","file_id":"13834","relation":"main_file"},{"creator":"jdanzl","content_type":"image/tiff","file_size":59680727,"access_level":"open_access","file_name":"Supplfig12_a_01.tif","success":1,"checksum":"2a4e1771e2f06383894361ba2a8155b4","date_updated":"2023-08-03T14:14:29Z","date_created":"2023-08-03T14:14:29Z","file_id":"13835","relation":"main_file"},{"date_updated":"2023-08-03T14:14:34Z","date_created":"2023-08-03T14:14:34Z","checksum":"993c434069b9d1bcb09bfe70628f5bbe","success":1,"relation":"main_file","file_id":"13836","file_size":106696749,"content_type":"image/tiff","creator":"jdanzl","file_name":"Supplfig12_a_02_n2v.tif","access_level":"open_access"},{"content_type":"image/tiff","file_size":53367287,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig12_a_02.tif","checksum":"e3b6410d68e42004ef3857967707aeb3","success":1,"date_created":"2023-08-03T14:14:34Z","date_updated":"2023-08-03T14:14:34Z","relation":"main_file","file_id":"13837"},{"access_level":"open_access","file_name":"Supplfig12_a_03_n2v.tif","creator":"jdanzl","content_type":"image/tiff","file_size":149937979,"file_id":"13838","relation":"main_file","success":1,"checksum":"0156e99806fe1539d5f48ea16c78e8c8","date_created":"2023-08-03T14:14:41Z","date_updated":"2023-08-03T14:14:41Z"},{"creator":"jdanzl","content_type":"image/tiff","file_size":74987927,"access_level":"open_access","file_name":"Supplfig12_a_03.tif","success":1,"checksum":"6cc1533a221526a072a0b09fb44bcf50","date_created":"2023-08-03T14:14:39Z","date_updated":"2023-08-03T14:14:39Z","file_id":"13839","relation":"main_file"},{"checksum":"f134834bd0d5e8c22e5a35aadf592007","success":1,"date_updated":"2023-08-03T14:14:53Z","date_created":"2023-08-03T14:14:53Z","relation":"main_file","file_id":"13840","content_type":"image/tiff","file_size":305581862,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig12_a_04_n2v.tif"},{"creator":"jdanzl","content_type":"image/tiff","file_size":152821840,"access_level":"open_access","file_name":"Supplfig12_a_04.tif","success":1,"checksum":"212ec76c02552fa1eef91e7bca9f07f7","date_created":"2023-08-03T14:14:50Z","date_updated":"2023-08-03T14:14:50Z","file_id":"13841","relation":"main_file"},{"creator":"jdanzl","content_type":"image/tiff","file_size":48082029,"access_level":"open_access","file_name":"Supplfig12_a_05_n2v.tif","success":1,"checksum":"7d99807d5b4313b04b4b5e0fbc08ba78","date_updated":"2023-08-03T14:14:52Z","date_created":"2023-08-03T14:14:52Z","file_id":"13842","relation":"main_file"},{"file_name":"Supplfig12_a_05.tif","access_level":"open_access","creator":"jdanzl","file_size":24059983,"content_type":"image/tiff","file_id":"13843","relation":"main_file","date_created":"2023-08-03T14:14:53Z","date_updated":"2023-08-03T14:14:53Z","success":1,"checksum":"a6d4024a8c6fa073a532cc0c78323df7"},{"file_size":305581860,"content_type":"image/tiff","creator":"jdanzl","file_name":"Supplfig12_a_06_n2v.tif","access_level":"open_access","date_updated":"2023-08-03T14:15:09Z","date_created":"2023-08-03T14:15:09Z","checksum":"1c42ad5423636478fe57495a3b506746","success":1,"relation":"main_file","file_id":"13844"},{"checksum":"821f1d31c6dbe68eb2513fb7520b5272","success":1,"date_updated":"2023-08-03T14:15:04Z","date_created":"2023-08-03T14:15:04Z","relation":"main_file","file_id":"13845","file_size":152821840,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Supplfig12_a_06.tif"},{"file_name":"Supplfig12_a_07_n2v.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":66855793,"file_id":"13846","relation":"main_file","date_updated":"2023-08-03T14:15:08Z","date_created":"2023-08-03T14:15:08Z","success":1,"checksum":"86a4dc1e4948c4bc9c71e6d55b4fd104"},{"relation":"main_file","file_id":"13847","date_updated":"2023-08-03T14:15:09Z","date_created":"2023-08-03T14:15:09Z","checksum":"fd5d45b1135800124fec635c4667dafe","success":1,"file_name":"Supplfig12_a_07.tif","access_level":"open_access","file_size":33446807,"content_type":"image/tiff","creator":"jdanzl"},{"file_name":"Supplfig12_a_08_n2v.tif","access_level":"open_access","content_type":"image/tiff","file_size":231476260,"creator":"jdanzl","relation":"main_file","file_id":"13848","date_updated":"2023-08-03T14:15:19Z","date_created":"2023-08-03T14:15:19Z","checksum":"5683760cc119a09f0b7de8fea98cda9c","success":1},{"success":1,"checksum":"0c336d554bcd8524f11bd25c2188b56f","date_updated":"2023-08-03T14:15:15Z","date_created":"2023-08-03T14:15:15Z","file_id":"13849","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":115769040,"access_level":"open_access","file_name":"Supplfig12_a_08.tif"},{"content_type":"image/tiff","file_size":305581869,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig12_a_09_n2v.tif","checksum":"fcaea6c95c363bd864a524fca8ed8e9b","success":1,"date_created":"2023-08-03T14:15:31Z","date_updated":"2023-08-03T14:15:31Z","relation":"main_file","file_id":"13850"},{"checksum":"f401f1875f072c345d106a1e419f9d13","success":1,"date_updated":"2023-08-03T14:15:28Z","date_created":"2023-08-03T14:15:28Z","relation":"main_file","file_id":"13851","file_size":152821840,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Supplfig12_a_09.tif"},{"access_level":"open_access","file_name":"Supplfig12_a_10_n2v.tif","file_size":266386255,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13852","checksum":"7ad7d5b1ac81da1ec3d5003d00ee870a","success":1,"date_created":"2023-08-03T14:15:42Z","date_updated":"2023-08-03T14:15:42Z"},{"success":1,"checksum":"77b93d082debd5248348c0a1e886eab9","date_created":"2023-08-03T14:15:40Z","date_updated":"2023-08-03T14:15:40Z","file_id":"13853","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":133239040,"access_level":"open_access","file_name":"Supplfig12_a_10.tif"},{"date_created":"2023-08-03T14:15:49Z","date_updated":"2023-08-03T14:15:49Z","success":1,"checksum":"5ece1d503f05133d07d5b867f666d7a8","file_id":"13854","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":191866269,"file_name":"Supplfig12_a_11_n2v.tif","access_level":"open_access"},{"success":1,"checksum":"a72ee7ab433097752ff00a63421d4b61","date_updated":"2023-08-03T14:15:48Z","date_created":"2023-08-03T14:15:48Z","file_id":"13855","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":95955040,"access_level":"open_access","file_name":"Supplfig12_a_11.tif"},{"relation":"main_file","file_id":"13856","checksum":"c9c6e4692e0e7f305a43058b201b50d3","success":1,"date_updated":"2023-08-03T14:16:49Z","date_created":"2023-08-03T14:16:49Z","access_level":"open_access","file_name":"Supplfig13_i.tif","file_size":55281,"content_type":"image/tiff","creator":"jdanzl"},{"creator":"jdanzl","file_size":55193,"content_type":"image/tiff","access_level":"open_access","file_name":"Supplfig13_ii.tif","success":1,"checksum":"345d11dbd70123d9d2723b547cbfc4fc","date_updated":"2023-08-03T14:16:49Z","date_created":"2023-08-03T14:16:49Z","file_id":"13857","relation":"main_file"},{"relation":"main_file","file_id":"13858","checksum":"b4c74c08077cfd3e11bfd6ea9ee1c5b2","success":1,"date_created":"2023-08-03T14:16:49Z","date_updated":"2023-08-03T14:16:49Z","access_level":"open_access","file_name":"Supplfig13_n2v+predict.tif","content_type":"image/tiff","file_size":539037,"creator":"jdanzl"},{"access_level":"open_access","file_name":"Supplfig14_a_n2v.tif","creator":"jdanzl","file_size":854898609,"content_type":"image/tiff","file_id":"13859","relation":"main_file","success":1,"checksum":"15f5b44257d075f9e45811304dfd5f85","date_created":"2023-08-03T14:18:10Z","date_updated":"2023-08-03T14:18:10Z"},{"access_level":"open_access","file_name":"Supplfig15_a_1.png","creator":"jdanzl","content_type":"image/png","file_size":7514502,"file_id":"13860","relation":"main_file","success":1,"checksum":"a9ca03e3e5696988d06fc6ab1c103440","date_updated":"2023-08-03T14:19:58Z","date_created":"2023-08-03T14:19:58Z"},{"access_level":"open_access","file_name":"Supplfig15_a_2.png","creator":"jdanzl","content_type":"image/png","file_size":1784041,"file_id":"13861","relation":"main_file","success":1,"checksum":"4be3451e203a0fc5d9eb14279ff68a7a","date_created":"2023-08-03T14:19:58Z","date_updated":"2023-08-03T14:19:58Z"},{"date_created":"2023-08-03T14:19:58Z","date_updated":"2023-08-03T14:19:58Z","success":1,"checksum":"43068c31eecddb798dbf2f51bda9b6c9","file_id":"13862","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":6030878,"file_name":"Supplfig15_b_1.tif","access_level":"open_access"},{"access_level":"open_access","file_name":"Supplfig15_b_2.tif","creator":"jdanzl","file_size":723293,"content_type":"image/tiff","file_id":"13863","relation":"main_file","success":1,"checksum":"ded4c0797f1a9152dc3128f1bb8c32a5","date_created":"2023-08-03T14:19:58Z","date_updated":"2023-08-03T14:19:58Z"},{"file_name":"Supplfig15_c_i.tif","access_level":"open_access","creator":"jdanzl","file_size":723409,"content_type":"image/tiff","file_id":"13864","relation":"main_file","date_updated":"2023-08-03T14:19:58Z","date_created":"2023-08-03T14:19:58Z","success":1,"checksum":"705394732d94bd8463479aee83c2d36e"},{"creator":"jdanzl","content_type":"image/tiff","file_size":723409,"access_level":"open_access","file_name":"Supplfig15_c_ii.tif","success":1,"checksum":"e08efe220bec6a93d583cab17754dd19","date_updated":"2023-08-03T14:19:58Z","date_created":"2023-08-03T14:19:58Z","file_id":"13865","relation":"main_file"},{"file_size":31572914,"content_type":"image/tiff","creator":"jdanzl","file_name":"Supplfig15_c.tif","access_level":"open_access","date_created":"2023-08-03T14:19:59Z","date_updated":"2023-08-03T14:19:59Z","checksum":"0e08e5d965815240b0a8195e0f899aab","success":1,"relation":"main_file","file_id":"13866"},{"date_created":"2023-08-03T14:19:59Z","date_updated":"2023-08-03T14:19:59Z","checksum":"594696a77d4a9be512046be5e2d602f0","success":1,"relation":"main_file","file_id":"13867","file_size":6030752,"content_type":"image/tiff","creator":"jdanzl","file_name":"Supplfig15_d_1.tif","access_level":"open_access"},{"relation":"main_file","file_id":"13868","checksum":"ffe6733eb77858008c4ca07b5f8c432b","success":1,"date_updated":"2023-08-03T14:19:59Z","date_created":"2023-08-03T14:19:59Z","access_level":"open_access","file_name":"Supplfig15_d_2.tif","content_type":"image/tiff","file_size":8005495,"creator":"jdanzl"},{"file_id":"13869","relation":"main_file","success":1,"checksum":"663bf013cf1e5019e1e7ddd2d12fa492","date_updated":"2023-08-03T14:20:56Z","date_created":"2023-08-03T14:20:56Z","access_level":"open_access","file_name":"Supplfig16_a.tif","creator":"jdanzl","content_type":"image/tiff","file_size":11117709},{"file_name":"Supplfig16_b.tif","access_level":"open_access","file_size":113709,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13870","date_created":"2023-08-03T14:20:56Z","date_updated":"2023-08-03T14:20:56Z","checksum":"80aee233dc2a1f26ed8cc323270cf3a9","success":1},{"file_name":"Supplfig16_c.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":113709,"file_id":"13871","relation":"main_file","date_created":"2023-08-03T14:20:56Z","date_updated":"2023-08-03T14:20:56Z","success":1,"checksum":"3b408e9345df2f16a942ad4ea61739b7"},{"creator":"jdanzl","content_type":"image/tiff","file_size":6003131,"file_name":"Supplfig17_a_1.tif","access_level":"open_access","date_created":"2023-08-03T14:25:47Z","date_updated":"2023-08-03T14:25:47Z","success":1,"checksum":"fbf688ef1f907149f92e9e936d02df72","file_id":"13872","relation":"main_file"},{"checksum":"9a56470f251f14b43903036fab338f76","success":1,"date_updated":"2023-08-03T14:25:47Z","date_created":"2023-08-03T14:25:47Z","relation":"main_file","file_id":"13873","content_type":"image/tiff","file_size":8004085,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig17_a_2.tif"},{"relation":"main_file","file_id":"13874","date_updated":"2023-08-03T14:25:47Z","date_created":"2023-08-03T14:25:47Z","checksum":"4578c020ba5d0a6ffe2a8a1c22e52c75","success":1,"file_name":"Supplfig17_a_3.tif","access_level":"open_access","content_type":"image/tiff","file_size":6003123,"creator":"jdanzl"},{"date_created":"2023-08-03T14:25:47Z","date_updated":"2023-08-03T14:25:47Z","success":1,"checksum":"a681d32f515da3bff8e803946f1d8b50","file_id":"13875","relation":"main_file","creator":"jdanzl","file_size":6003131,"content_type":"image/tiff","file_name":"Supplfig17_a_4.tif","access_level":"open_access"},{"content_type":"image/tiff","file_size":6003131,"creator":"jdanzl","file_name":"Supplfig17_a_5.tif","access_level":"open_access","date_updated":"2023-08-03T14:25:47Z","date_created":"2023-08-03T14:25:47Z","checksum":"b89d366c39e25d17dc5d8ceee9145c8b","success":1,"relation":"main_file","file_id":"13876"},{"creator":"jdanzl","content_type":"image/tiff","file_size":6003079,"access_level":"open_access","file_name":"Supplfig17_a_6.tif","success":1,"checksum":"0b9d60f0aba79525a97c122d972f0b22","date_updated":"2023-08-03T14:25:47Z","date_created":"2023-08-03T14:25:47Z","file_id":"13877","relation":"main_file"},{"file_name":"Supplfig17_a_7.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":6003115,"file_id":"13878","relation":"main_file","date_updated":"2023-08-03T14:25:47Z","date_created":"2023-08-03T14:25:47Z","success":1,"checksum":"169aad3cea521cc2a0ce4c3e41473e0c"},{"file_id":"13879","relation":"main_file","date_updated":"2023-08-03T14:25:47Z","date_created":"2023-08-03T14:25:47Z","success":1,"checksum":"39a44d77d9047bfa10da8d9c9bd7b391","file_name":"Supplfig17_a_8.tif","access_level":"open_access","creator":"jdanzl","file_size":4002129,"content_type":"image/tiff"},{"checksum":"f4ecb2bd44f2cea3d71587670344ac40","success":1,"date_created":"2023-08-03T14:25:48Z","date_updated":"2023-08-03T14:25:48Z","relation":"main_file","file_id":"13880","file_size":8214335,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Supplfig17_b.tif"},{"file_id":"13881","relation":"main_file","success":1,"checksum":"44a20d2621680c90227416bf32b5a566","date_created":"2023-08-03T14:27:06Z","date_updated":"2023-08-03T14:27:06Z","access_level":"open_access","file_name":"Supplfig18_a.tif","creator":"jdanzl","content_type":"image/tiff","file_size":7471479},{"file_name":"Supplfig18_b.tif","access_level":"open_access","creator":"jdanzl","file_size":290625,"content_type":"image/tiff","file_id":"13882","relation":"main_file","date_updated":"2023-08-03T14:27:06Z","date_created":"2023-08-03T14:27:06Z","success":1,"checksum":"5a5f7b616785f9213064e8c77f9d38c4"},{"access_level":"open_access","file_name":"Supplfig18_c.tif","file_size":411767,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13883","checksum":"8f621722a636e808a03d85f9597ad1a2","success":1,"date_updated":"2023-08-03T14:27:07Z","date_created":"2023-08-03T14:27:07Z"},{"date_updated":"2023-08-03T14:27:07Z","date_created":"2023-08-03T14:27:07Z","checksum":"3c8356f9170fe345e2ef725cd7d1b167","success":1,"relation":"main_file","file_id":"13884","content_type":"image/tiff","file_size":11117685,"creator":"jdanzl","file_name":"Supplfig18_d.tif","access_level":"open_access"},{"creator":"jdanzl","file_size":259509773,"content_type":"image/tiff","access_level":"open_access","file_name":"Supplfig18_e_n2v.tif","success":1,"checksum":"5c8443e97724b54f359f7355483b890e","date_updated":"2023-08-03T14:27:10Z","date_created":"2023-08-03T14:27:10Z","file_id":"13885","relation":"main_file"},{"file_name":"Supplfig19_n2v.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":1430939360,"file_id":"13886","relation":"main_file","date_created":"2023-08-03T14:29:25Z","date_updated":"2023-08-03T14:29:25Z","success":1,"checksum":"413e3105c1bcd2ac2c569fa2b06253f2"},{"checksum":"a864dc5b54f469c723e86286d538bb52","success":1,"date_updated":"2023-08-03T14:29:16Z","date_created":"2023-08-03T14:29:16Z","relation":"main_file","file_id":"13887","file_size":715524468,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Supplfig19.tif"},{"access_level":"open_access","file_name":"Supplfig20_a_left.tif","creator":"jdanzl","file_size":8004743,"content_type":"image/tiff","file_id":"13888","relation":"main_file","success":1,"checksum":"8a78ce49446d207c0bf31196b788fa93","date_updated":"2023-08-03T14:32:54Z","date_created":"2023-08-03T14:32:54Z"},{"file_name":"Supplfig20_a_right.tif","access_level":"open_access","file_size":5561081,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13889","date_updated":"2023-08-03T14:32:54Z","date_created":"2023-08-03T14:32:54Z","checksum":"48fa3abfd16a00c7a3757d6452a482ec","success":1},{"access_level":"open_access","file_name":"Supplfig20_b_1.tif","content_type":"image/tiff","file_size":8456797,"creator":"jdanzl","relation":"main_file","file_id":"13890","checksum":"85d82cd94dd3202f04b5987bc4466573","success":1,"date_updated":"2023-08-03T14:32:54Z","date_created":"2023-08-03T14:32:54Z"},{"date_updated":"2023-08-03T14:32:54Z","date_created":"2023-08-03T14:32:54Z","checksum":"e16f04d5d4d40f6ec33456d0cf02e1eb","success":1,"relation":"main_file","file_id":"13891","content_type":"image/tiff","file_size":8456795,"creator":"jdanzl","file_name":"Supplfig20_b_2.tif","access_level":"open_access"},{"file_size":8456796,"content_type":"image/tiff","creator":"jdanzl","file_name":"Supplfig20_b_3.tif","access_level":"open_access","date_created":"2023-08-03T14:32:54Z","date_updated":"2023-08-03T14:32:54Z","checksum":"ff190edb269c28b25d27bffaeb7d25cf","success":1,"relation":"main_file","file_id":"13892"},{"relation":"main_file","file_id":"13893","date_updated":"2023-08-03T14:32:54Z","date_created":"2023-08-03T14:32:54Z","checksum":"deb10b81bae62d9e20e681411fb75fcc","success":1,"file_name":"Supplfig20_b_4.tif","access_level":"open_access","file_size":8538887,"content_type":"image/tiff","creator":"jdanzl"},{"date_updated":"2023-08-03T14:32:54Z","date_created":"2023-08-03T14:32:54Z","checksum":"5c64bb94e76030d7a9d8624bac4b0f57","success":1,"relation":"main_file","file_id":"13894","file_size":8538851,"content_type":"image/tiff","creator":"jdanzl","file_name":"Supplfig20_b_5.tif","access_level":"open_access"},{"content_type":"image/tiff","file_size":11077737,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig20_c_1.tif","checksum":"d6c20232c4bd36e213b4c456c5009644","success":1,"date_created":"2023-08-03T14:32:54Z","date_updated":"2023-08-03T14:32:54Z","relation":"main_file","file_id":"13895"},{"date_created":"2023-08-03T14:32:54Z","date_updated":"2023-08-03T14:32:54Z","checksum":"49c3396b8960af3f6fd8f6b078971d51","success":1,"relation":"main_file","file_id":"13896","file_size":11077737,"content_type":"image/tiff","creator":"jdanzl","file_name":"Supplfig20_c_2.tif","access_level":"open_access"},{"file_name":"Supplfig20_c_3.tif","access_level":"open_access","content_type":"image/tiff","file_size":11077737,"creator":"jdanzl","relation":"main_file","file_id":"13897","date_created":"2023-08-03T14:32:55Z","date_updated":"2023-08-03T14:32:55Z","checksum":"73471528f691fb337839b84c31014da4","success":1},{"access_level":"open_access","file_name":"Supplfig20_c_4.tif","file_size":11077737,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13898","checksum":"47a0fd1a36d7e7907ce18007bdaaa145","success":1,"date_updated":"2023-08-03T14:32:55Z","date_created":"2023-08-03T14:32:55Z"},{"date_updated":"2023-08-03T14:32:55Z","date_created":"2023-08-03T14:32:55Z","checksum":"0c74b07f13fb08a91e61669368f38c9a","success":1,"relation":"main_file","file_id":"13899","file_size":11077737,"content_type":"image/tiff","creator":"jdanzl","file_name":"Supplfig20_c_5.tif","access_level":"open_access"},{"access_level":"open_access","file_name":"Supplfig20_d_1.tif","creator":"jdanzl","file_size":4002133,"content_type":"image/tiff","file_id":"13900","relation":"main_file","success":1,"checksum":"fe3b76446ec8bd0d5cdba94a128a84b8","date_created":"2023-08-03T14:32:55Z","date_updated":"2023-08-03T14:32:55Z"},{"file_id":"13901","relation":"main_file","date_updated":"2023-08-03T14:32:55Z","date_created":"2023-08-03T14:32:55Z","success":1,"checksum":"0570bab9a471af3d0d1d8bf9a3cb17e7","file_name":"Supplfig20_d_2.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":4002133},{"relation":"main_file","file_id":"13902","checksum":"59f330990b5c95f98a768761a009940c","success":1,"date_created":"2023-08-03T14:32:55Z","date_updated":"2023-08-03T14:32:55Z","access_level":"open_access","file_name":"Supplfig20_d_3.tif","content_type":"image/tiff","file_size":4002199,"creator":"jdanzl"},{"access_level":"open_access","file_name":"Supplfig20_d_4.tif","creator":"jdanzl","content_type":"image/tiff","file_size":4002133,"file_id":"13903","relation":"main_file","success":1,"checksum":"f0da06f2a278dff4bbd1aeace11700bf","date_updated":"2023-08-03T14:32:55Z","date_created":"2023-08-03T14:32:55Z"},{"access_level":"open_access","file_name":"Supplfig20_d_5.tif","creator":"jdanzl","content_type":"image/tiff","file_size":4002133,"file_id":"13904","relation":"main_file","success":1,"checksum":"e61d49dcc0952af3623cc26a78cc6495","date_created":"2023-08-03T14:32:55Z","date_updated":"2023-08-03T14:32:55Z"},{"file_id":"13905","relation":"main_file","date_created":"2023-08-03T14:42:01Z","date_updated":"2023-08-03T14:42:01Z","success":1,"checksum":"bcf8294487abaf1a75033f388fba06ec","file_name":"Supplfig22_b_1.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":12627576},{"content_type":"image/tiff","file_size":8543366,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig22_b_2.tif","checksum":"14097feb4a73e7bb1e1694cef0115cab","success":1,"date_created":"2023-08-03T14:42:01Z","date_updated":"2023-08-03T14:42:01Z","relation":"main_file","file_id":"13906"},{"file_id":"13907","relation":"main_file","date_updated":"2023-08-03T14:42:04Z","date_created":"2023-08-03T14:42:04Z","success":1,"checksum":"7e74b8cff2ada56d47d135a6a9e71e76","file_name":"Supplfig22_b_3.tif","access_level":"open_access","creator":"jdanzl","file_size":8394010,"content_type":"image/tiff"},{"file_id":"13908","relation":"main_file","date_created":"2023-08-03T15:35:39Z","date_updated":"2023-08-03T15:35:39Z","success":1,"checksum":"f6e6e0f0e3854fedd201ab8ff08a7651","file_name":"Supplfig22_b_4.tif","access_level":"open_access","creator":"jdanzl","file_size":8682992,"content_type":"image/tiff"},{"checksum":"6ddeb84249768b46b9c2072bf85bdc8b","success":1,"date_updated":"2023-08-03T14:42:04Z","date_created":"2023-08-03T14:42:04Z","relation":"main_file","file_id":"13909","file_size":8503466,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Supplfig22_b_5.tif"},{"success":1,"checksum":"40648b8a4ef375b8352f11a6772ea1a6","date_updated":"2023-08-03T14:42:04Z","date_created":"2023-08-03T14:42:04Z","file_id":"13910","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":8543342,"access_level":"open_access","file_name":"Supplfig22_b_6.tif"},{"file_id":"13911","relation":"main_file","success":1,"checksum":"78f601de4d88f6ccb97861eaf4a995f8","date_updated":"2023-08-03T14:42:06Z","date_created":"2023-08-03T14:42:06Z","access_level":"open_access","file_name":"Supplfig22_b_7.tif","creator":"jdanzl","content_type":"image/tiff","file_size":33588990},{"date_updated":"2023-08-03T14:42:41Z","date_created":"2023-08-03T14:42:41Z","success":1,"checksum":"2873c488b7c8ad4d111726025086e9ea","file_id":"13912","relation":"main_file","creator":"jdanzl","file_size":1453171518,"content_type":"image/tiff","file_name":"Supplfig22_c.tif","access_level":"open_access"},{"relation":"main_file","file_id":"13913","date_created":"2023-08-03T14:47:43Z","date_updated":"2023-08-03T14:47:43Z","checksum":"c1d0e5e61ac0d0ddf08704769f80ac78","success":1,"file_name":"Supplfig23_a.tif","access_level":"open_access","file_size":1325919782,"content_type":"image/tiff","creator":"jdanzl"},{"file_id":"13914","relation":"main_file","success":1,"checksum":"f97632984b6a73e06cc0c8c947cdcc71","date_updated":"2023-08-03T14:47:25Z","date_created":"2023-08-03T14:47:25Z","access_level":"open_access","file_name":"Supplfig23_b.tif","creator":"jdanzl","file_size":31366288,"content_type":"image/tiff"},{"file_id":"13915","relation":"main_file","success":1,"checksum":"16f4c17835a79d7c06e2a97b1603baf1","date_updated":"2023-08-03T14:47:26Z","date_created":"2023-08-03T14:47:26Z","access_level":"open_access","file_name":"Supplfig23_c.tif","creator":"jdanzl","file_size":31366288,"content_type":"image/tiff"},{"relation":"main_file","file_id":"13916","checksum":"00f35ca77165642ca9b3bc3608bd04c1","success":1,"date_updated":"2023-08-03T14:47:27Z","date_created":"2023-08-03T14:47:27Z","access_level":"open_access","file_name":"Supplfig23_d.tif","content_type":"image/tiff","file_size":31366428,"creator":"jdanzl"},{"file_size":31500832,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Supplfig23_e.tif","checksum":"1aff850f47ae8c8f05ca48ff9faa38b1","success":1,"date_updated":"2023-08-03T14:47:27Z","date_created":"2023-08-03T14:47:27Z","relation":"main_file","file_id":"13917"},{"access_level":"open_access","file_name":"Supplfig24_a_i.tif","creator":"jdanzl","content_type":"image/tiff","file_size":44179078,"file_id":"13918","relation":"main_file","success":1,"checksum":"f644de697d142c83461ed5ad1d72a043","date_updated":"2023-08-03T14:48:38Z","date_created":"2023-08-03T14:48:38Z"},{"content_type":"image/tiff","file_size":44125924,"creator":"jdanzl","file_name":"Supplfig24_a_ii.tif","access_level":"open_access","date_created":"2023-08-03T14:48:38Z","date_updated":"2023-08-03T14:48:38Z","checksum":"eccb84925a6699b396d4b07efcbc7349","success":1,"relation":"main_file","file_id":"13919"},{"checksum":"afe7253e70ec79144e59b28c3c66703a","success":1,"date_updated":"2023-08-03T14:48:54Z","date_created":"2023-08-03T14:48:54Z","relation":"main_file","file_id":"13920","file_size":1061835435,"content_type":"image/tiff","creator":"jdanzl","access_level":"open_access","file_name":"Supplfig24_a.tif"},{"relation":"main_file","file_id":"13921","date_updated":"2023-08-03T14:48:39Z","date_created":"2023-08-03T14:48:39Z","checksum":"94a03b022aa84ea6e8515450a481ad82","success":1,"file_name":"Supplfig24_b_iii.tif","access_level":"open_access","file_size":3977824,"content_type":"image/tiff","creator":"jdanzl"},{"file_name":"Supplfig24_b_iv.tif","access_level":"open_access","file_size":3977825,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13922","date_updated":"2023-08-03T14:48:39Z","date_created":"2023-08-03T14:48:39Z","checksum":"166832c173fcda88ec6e35decdf0d197","success":1},{"file_id":"13923","relation":"main_file","success":1,"checksum":"53175073b83ab569241ae64ef7f180b3","date_updated":"2023-08-03T14:51:27Z","date_created":"2023-08-03T14:51:27Z","access_level":"open_access","file_name":"Supplfig25_a_1.tif","creator":"jdanzl","file_size":37641738,"content_type":"image/tiff"},{"creator":"jdanzl","content_type":"image/tiff","file_size":4932897,"file_name":"Supplfig25_a_2.tif","access_level":"open_access","date_updated":"2023-08-03T14:51:26Z","date_created":"2023-08-03T14:51:26Z","success":1,"checksum":"70e6a1780daeae6a5bef2c27c996c442","file_id":"13924","relation":"main_file"},{"creator":"jdanzl","content_type":"image/tiff","file_size":357433570,"file_name":"Supplfig25_b_1.tif","access_level":"open_access","date_updated":"2023-08-03T14:51:31Z","date_created":"2023-08-03T14:51:31Z","success":1,"checksum":"1748266d7b8a2ae1f6292b9c265c2068","file_id":"13925","relation":"main_file"},{"access_level":"open_access","file_name":"Supplfig25_b_2.tif","file_size":27734506,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13926","checksum":"8490f44160a482ea06d858eb3bc25a11","success":1,"date_updated":"2023-08-03T14:51:27Z","date_created":"2023-08-03T14:51:27Z"},{"creator":"jdanzl","content_type":"image/tiff","file_size":35082394,"access_level":"open_access","file_name":"Suppfig26_h.tif","success":1,"checksum":"e5e9c550cc934a7725dc209c79951847","date_created":"2023-08-03T14:53:43Z","date_updated":"2023-08-03T14:53:43Z","file_id":"13927","relation":"main_file"},{"file_name":"Supplfig26_a_1.tif","access_level":"open_access","file_size":16676477,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13928","date_created":"2023-08-03T14:53:42Z","date_updated":"2023-08-03T14:53:42Z","checksum":"39ae411d1e950e78bdc12937fb36f661","success":1},{"file_name":"Supplfig26_a_2.tif","access_level":"open_access","creator":"jdanzl","file_size":170493,"content_type":"image/tiff","file_id":"13929","relation":"main_file","date_created":"2023-08-03T14:53:42Z","date_updated":"2023-08-03T14:53:42Z","success":1,"checksum":"450f5d0e8091639e27eb7a7991524e88"},{"file_name":"Supplfig26_b_1.tif","access_level":"open_access","creator":"jdanzl","file_size":11117737,"content_type":"image/tiff","file_id":"13930","relation":"main_file","date_updated":"2023-08-03T14:53:43Z","date_created":"2023-08-03T14:53:43Z","success":1,"checksum":"8e5a71801fa1fcb7f679d1af23344662"},{"access_level":"open_access","file_name":"Supplfig26_b_2.tif","creator":"jdanzl","content_type":"image/tiff","file_size":113753,"file_id":"13931","relation":"main_file","success":1,"checksum":"519fb0326a0f0774b3edc1dafffcdd08","date_updated":"2023-08-03T14:53:43Z","date_created":"2023-08-03T14:53:43Z"},{"content_type":"image/tiff","file_size":495452386,"creator":"jdanzl","file_name":"Supplfig26_c.tif","access_level":"open_access","date_updated":"2023-08-03T14:53:52Z","date_created":"2023-08-03T14:53:52Z","checksum":"d051c7d717eeb6f2ca59d8727ea62200","success":1,"relation":"main_file","file_id":"13932"},{"relation":"main_file","file_id":"13933","date_created":"2023-08-03T14:53:46Z","date_updated":"2023-08-03T14:53:46Z","checksum":"5437b53e708572e2e9ad1432c260a04f","success":1,"file_name":"Supplfig26_d.tif","access_level":"open_access","file_size":132167170,"content_type":"image/tiff","creator":"jdanzl"},{"access_level":"open_access","file_name":"Supplfig26_e.tif","content_type":"image/tiff","file_size":11431214,"creator":"jdanzl","relation":"main_file","file_id":"13934","checksum":"0baab38829a8587ded5e39f85068124b","success":1,"date_created":"2023-08-03T14:53:46Z","date_updated":"2023-08-03T14:53:46Z"},{"date_updated":"2023-08-03T14:53:48Z","date_created":"2023-08-03T14:53:48Z","checksum":"afa57f254c9dd987d90d5e43db3fb9e6","success":1,"relation":"main_file","file_id":"13935","content_type":"image/tiff","file_size":64005702,"creator":"jdanzl","file_name":"Supplfig26_f.tif","access_level":"open_access"},{"checksum":"c35ba67ab92c410cb4370f91f3dea819","success":1,"date_updated":"2023-08-03T14:53:52Z","date_created":"2023-08-03T14:53:52Z","relation":"main_file","file_id":"13936","content_type":"image/tiff","file_size":246421054,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig26_g.tif"},{"file_name":"Supplfig27_a.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":166614932,"file_id":"13937","relation":"main_file","date_created":"2023-08-03T14:56:43Z","date_updated":"2023-08-03T14:56:43Z","success":1,"checksum":"3fd6186d73cbce1be79cf14a94a7f3bd"},{"access_level":"open_access","file_name":"Supplfig27_b.tif","file_size":143583446,"content_type":"image/tiff","creator":"jdanzl","relation":"main_file","file_id":"13938","checksum":"d1fc4c88e8e258e4e536a26e196d09b0","success":1,"date_created":"2023-08-03T14:56:42Z","date_updated":"2023-08-03T14:56:42Z"},{"success":1,"checksum":"8d6985530e86f38548e89e6380d73771","date_created":"2023-08-03T14:56:47Z","date_updated":"2023-08-03T14:56:47Z","file_id":"13939","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":172528188,"access_level":"open_access","file_name":"Supplfig27_c.tif"},{"file_id":"13940","relation":"main_file","date_created":"2023-08-03T14:56:46Z","date_updated":"2023-08-03T14:56:46Z","success":1,"checksum":"d0b1309d2120892ede84e04fdf0dbfbf","file_name":"Supplfig27_d.tif","access_level":"open_access","creator":"jdanzl","content_type":"image/tiff","file_size":113699256},{"success":1,"checksum":"4789b5254d0415ce314fc9e39cc52121","date_updated":"2023-08-03T14:56:47Z","date_created":"2023-08-03T14:56:47Z","file_id":"13941","relation":"main_file","creator":"jdanzl","content_type":"image/tiff","file_size":88664548,"access_level":"open_access","file_name":"Supplfig27_e.tif"},{"relation":"main_file","file_id":"13942","checksum":"7ff2d06534f062b0f17dab181f6c1f4e","success":1,"date_created":"2023-08-03T14:56:47Z","date_updated":"2023-08-03T14:56:47Z","access_level":"open_access","file_name":"Supplfig27_f.tif","content_type":"image/tiff","file_size":2298356,"creator":"jdanzl"},{"creator":"jdanzl","file_size":499618,"content_type":"image/tiff","access_level":"open_access","file_name":"Supplfig27_g_1.tif","success":1,"checksum":"46de66d457b0def90f753c11927536b7","date_updated":"2023-08-03T14:56:47Z","date_created":"2023-08-03T14:56:47Z","file_id":"13943","relation":"main_file"},{"success":1,"checksum":"9ef5fba064a73a79dbc74b5e166d08ec","date_created":"2023-08-03T14:56:50Z","date_updated":"2023-08-03T14:56:50Z","file_id":"13944","relation":"main_file","creator":"jdanzl","file_size":202079026,"content_type":"image/tiff","access_level":"open_access","file_name":"Supplfig27_g_2.tif"},{"content_type":"image/tiff","file_size":14639269,"creator":"jdanzl","access_level":"open_access","file_name":"Supplfig27_g_3.tif","checksum":"bf956c2b58d3da2baa869db5206d8d49","success":1,"date_updated":"2023-08-03T14:56:48Z","date_created":"2023-08-03T14:56:48Z","relation":"main_file","file_id":"13945"},{"relation":"main_file","file_id":"13946","date_created":"2023-08-03T15:21:01Z","date_updated":"2023-08-03T15:21:01Z","checksum":"327dca11f42d5375d7f47f4cbd5b36c0","success":1,"file_name":"model.p","access_level":"open_access","content_type":"application/octet-stream","file_size":279467712,"creator":"jdanzl"}],"oa_version":"Published Version","type":"research_data","abstract":[{"lang":"eng","text":"Mapping the complex and dense arrangement of cells and their connectivity in brain tissue demands nanoscale spatial resolution imaging. Super-resolution optical microscopy excels at visualizing specific molecules and individual cells but fails to provide tissue context. Here, we developed Comprehensive Analysis of Tissues across Scales (CATS), a technology to densely map brain tissue architecture from millimeter regional to nanometer synaptic scales in diverse chemically fixed brain preparations, including rodent and human. CATS uses fixation-compatible extracellular labeling and optical imaging, including stimulated emission depletion or expansion microscopy, to comprehensively delineate cellular structures. It enables three-dimensional reconstruction of single synapses and mapping of synaptic connectivity by identification and analysis of putative synaptic cleft regions. Applying CATS to the mouse hippocampal mossy fiber circuitry, we reconstructed and quantified the synaptic input and output structure of identified neurons. We furthermore demonstrate applicability to clinically derived human tissue samples, including formalin-fixed paraffin-embedded routine diagnostic specimens, for visualizing the cellular architecture of brain tissue in health and disease."}],"oa":1,"tmp":{"name":"Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC BY-NC-SA 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode","image":"/images/cc_by_nc_sa.png","short":"CC BY-NC-SA (4.0)"},"project":[{"call_identifier":"FWF","name":"Optical control of synaptic function via adhesion molecules","grant_number":"I03600","_id":"265CB4D0-B435-11E9-9278-68D0E5697425"},{"grant_number":"W1232-B24","_id":"26AA4EF2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Molecular Drug Targets"},{"grant_number":"Z00312","_id":"25C5A090-B435-11E9-9278-68D0E5697425","name":"The Wittgenstein Prize","call_identifier":"FWF"},{"_id":"23889792-32DE-11EA-91FC-C7463DDC885E","name":"High content imaging to decode human immune cell interactions in health and allergic disease"},{"_id":"25444568-B435-11E9-9278-68D0E5697425","grant_number":"715508","name":"Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models","call_identifier":"H2020"},{"_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","grant_number":"692692","call_identifier":"H2020","name":"Biophysics and circuit function of a giant cortical glumatergic synapse"},{"grant_number":"665385","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"International IST Doctoral Program"},{"_id":"fc2be41b-9c52-11eb-aca3-faa90aa144e9","grant_number":"101026635","name":"Synaptic computations of the hippocampal CA3 circuitry","call_identifier":"H2020"}],"doi":"10.15479/AT:ISTA:13126","acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"Bio"},{"_id":"PreCl"},{"_id":"LifeSc"},{"_id":"M-Shop"},{"_id":"E-Lib"}],"month":"08","acknowledgement":"We thank Jakob Vorlaufer, Nathalie Agudelo-Dueñas, Wiebke Jahr, Andreas Wartak for microscope maintenance and troubleshooting, Caroline Kreuzinger, Anna Freeman, and Irene Erber for technical assistance and Matthias Tomschik for support with obtaining human samples. We gratefully acknowledge Eder Miguel for setting up webKnossos and Marek Šuplata for computational support and hardware control. We are grateful to Ryuichi Shigemoto and Bernd Bickel for generous support, and Michael Sixt and Scott Boyd (Stanford University) for discussions and critical reading of the manuscript. PSD95-HaloTag mice were kindly provided by Seth Grant (University of Edinburgh). We acknowledge expert support by IST Austria’s scientific computing, imaging and optics, preclinical, and lab support facilities, and by the Library and Miba machine shop.\r\nWe gratefully acknowledge funding by the following sources: \r\nAustrian Science Fund (FWF) grant I3600-B27 (JGD)\r\nAustrian Science Fund (FWF) grant DK W1232 (JGD, JMM)\r\nAustrian Science Fund (FWF) grant Z 312-B27, Wittgenstein award (PJ)\r\nAustrian Science Funds (FWF) projects I4685-B, I6565-B (SYNABS) and DOC 33-B27 (RH)\r\nGesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (JGD)\r\nEuropean Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 715508 – REVERSEAUTISM (GN)\r\nEuropean Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 692692 – GIANTSYN (PJ)\r\nMarie Skłodowska-Curie Actions Fellowship GA no. 665385 under the EU Horizon 2020 program (JMM, JL)\r\nMarie Skłodowska-Curie Actions Individual Fellowship 101026635 under the EU Horizon 2020 program (JFW)","year":"2023","publisher":"Institute of Science and Technology Austria","department":[{"_id":"JoDa"},{"_id":"SaSi"},{"_id":"GaNo"},{"_id":"PeJo"},{"_id":"Bio"},{"_id":"RySh"}],"contributor":[{"last_name":"Michalska","first_name":"Julia M","id":"443DB6DE-F248-11E8-B48F-1D18A9856A87"},{"id":"46E28B80-F248-11E8-B48F-1D18A9856A87","first_name":"Julia","last_name":"Lyudchik"},{"last_name":"Velicky","first_name":"Philipp","orcid":"0000-0002-2340-7431","id":"39BDC62C-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Stefanickova","first_name":"Hana","id":"ee3cb6ca-ec98-11ea-ae11-ff703e2254ed"},{"last_name":"Watson","first_name":"Jake","orcid":"0000-0002-8698-3823","id":"63836096-4690-11EA-BD4E-32803DDC885E"},{"first_name":"Alban","last_name":"Cenameri","id":"9ac8f577-2357-11eb-997a-e566c5550886"},{"id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1216-9105","first_name":"Christoph M","last_name":"Sommer"},{"id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3183-8207","first_name":"Nicole","last_name":"Amberg"},{"orcid":"0000-0003-2356-9403","id":"41CB84B2-F248-11E8-B48F-1D18A9856A87","last_name":"Venturino","first_name":"Alessandro"},{"last_name":"Roessler","first_name":"Karl"},{"first_name":"Thomas","last_name":"Czech"},{"first_name":"Romana","last_name":"Höftberger"},{"first_name":"Sandra","last_name":"Siegert","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8635-0877"},{"id":"3E57A680-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7673-7178","first_name":"Gaia","last_name":"Novarino"},{"id":"353C1B58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5001-4804","first_name":"Peter M","last_name":"Jonas"}],"related_material":{"record":[{"id":"14257","status":"public","relation":"used_in_publication"}],"link":[{"url":"https://pub.ista.ac.at/group_danzl/data/CATS/","description":"Original data for Fig. 5d, Fig. 5d (N2V) and Fig. 5f-i, provided via an external link due to the large size (>10GB) of the datasets. ","relation":"research_data"}]},"author":[{"id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8559-3973","first_name":"Johann G","last_name":"Danzl","full_name":"Danzl, Johann G"}],"date_updated":"2024-02-21T12:18:19Z","date_created":"2023-06-07T07:15:12Z","ec_funded":1,"file_date_updated":"2023-08-04T13:19:47Z","license":"https://creativecommons.org/licenses/by-nc-sa/4.0/"},{"_id":"14257","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","status":"public","title":"Imaging brain tissue architecture across millimeter to nanometer scales","oa_version":"Published Version","type":"journal_article","abstract":[{"text":"Mapping the complex and dense arrangement of cells and their connectivity in brain tissue demands nanoscale spatial resolution imaging. Super-resolution optical microscopy excels at visualizing specific molecules and individual cells but fails to provide tissue context. Here we developed Comprehensive Analysis of Tissues across Scales (CATS), a technology to densely map brain tissue architecture from millimeter regional to nanometer synaptic scales in diverse chemically fixed brain preparations, including rodent and human. CATS uses fixation-compatible extracellular labeling and optical imaging, including stimulated emission depletion or expansion microscopy, to comprehensively delineate cellular structures. It enables three-dimensional reconstruction of single synapses and mapping of synaptic connectivity by identification and analysis of putative synaptic cleft regions. Applying CATS to the mouse hippocampal mossy fiber circuitry, we reconstructed and quantified the synaptic input and output structure of identified neurons. We furthermore demonstrate applicability to clinically derived human tissue samples, including formalin-fixed paraffin-embedded routine diagnostic specimens, for visualizing the cellular architecture of brain tissue in health and disease.","lang":"eng"}],"publication":"Nature Biotechnology","citation":{"ama":"Michalska JM, Lyudchik J, Velicky P, et al. Imaging brain tissue architecture across millimeter to nanometer scales. Nature Biotechnology. 2023. doi:10.1038/s41587-023-01911-8","ista":"Michalska JM, Lyudchik J, Velicky P, Korinkova H, Watson J, Cenameri A, Sommer CM, Amberg N, Venturino A, Roessler K, Czech T, Höftberger R, Siegert S, Novarino G, Jonas PM, Danzl JG. 2023. Imaging brain tissue architecture across millimeter to nanometer scales. Nature Biotechnology.","apa":"Michalska, J. M., Lyudchik, J., Velicky, P., Korinkova, H., Watson, J., Cenameri, A., … Danzl, J. G. (2023). Imaging brain tissue architecture across millimeter to nanometer scales. Nature Biotechnology. Springer Nature. https://doi.org/10.1038/s41587-023-01911-8","ieee":"J. M. Michalska et al., “Imaging brain tissue architecture across millimeter to nanometer scales,” Nature Biotechnology. Springer Nature, 2023.","mla":"Michalska, Julia M., et al. “Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.” Nature Biotechnology, Springer Nature, 2023, doi:10.1038/s41587-023-01911-8.","short":"J.M. Michalska, J. Lyudchik, P. Velicky, H. Korinkova, J. Watson, A. Cenameri, C.M. Sommer, N. Amberg, A. Venturino, K. Roessler, T. Czech, R. Höftberger, S. Siegert, G. Novarino, P.M. Jonas, J.G. Danzl, Nature Biotechnology (2023).","chicago":"Michalska, Julia M, Julia Lyudchik, Philipp Velicky, Hana Korinkova, Jake Watson, Alban Cenameri, Christoph M Sommer, et al. “Imaging Brain Tissue Architecture across Millimeter to Nanometer Scales.” Nature Biotechnology. Springer Nature, 2023. https://doi.org/10.1038/s41587-023-01911-8."},"article_type":"original","date_published":"2023-08-31T00:00:00Z","scopus_import":"1","day":"31","article_processing_charge":"Yes (in subscription journal)","year":"2023","acknowledgement":"We thank J. Vorlaufer, N. Agudelo-Dueñas, W. Jahr and A. Wartak for microscope maintenance and troubleshooting; C. Kreuzinger, A. Freeman and I. Erber for technical assistance; and M. Tomschik for support with obtaining human samples. We gratefully acknowledge E. Miguel for setting up webKnossos and M. Šuplata for computational support and hardware control. We are grateful to R. Shigemoto and B. Bickel for generous support and M. Sixt and S. Boyd (Stanford University) for discussions and critical reading of the paper. PSD95-HaloTag mice were kindly provided by S. Grant (University of Edinburgh). We acknowledge expert support by Institute of Science and Technology Austria’s scientific computing, imaging and optics, preclinical and lab support facilities and by the Miba machine shop and library. We gratefully acknowledge funding by the following sources: Austrian Science Fund (FWF) grant I3600-B27 (J.G.D.); Austrian Science Fund (FWF) grant DK W1232 (J.G.D. and J.M.M.); Austrian Science Fund (FWF) grant Z 312-B27, Wittgenstein award (P.J.); Austrian Science Fund (FWF) projects I4685-B, I6565-B (SYNABS) and DOC 33-B27 (R.H.); Gesellschaft für Forschungsförderung NÖ (NFB) grant LSC18-022 (J.G.D.); European Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 715508 – REVERSEAUTISM (G.N.); European Union’s Horizon 2020 research and innovation programme, European Research Council (ERC) grant 692692 – GIANTSYN (P.J.); Marie Skłodowska-Curie Actions Fellowship GA no. 665385 under the EU Horizon 2020 program (J.M.M. and J.L.); and Marie Skłodowska-Curie Actions Individual Fellowship no. 101026635 under the EU Horizon 2020 program (J.F.W.).","publication_status":"epub_ahead","publisher":"Springer Nature","department":[{"_id":"SaSi"},{"_id":"GaNo"},{"_id":"PeJo"},{"_id":"JoDa"},{"_id":"Bio"},{"_id":"RySh"}],"author":[{"id":"443DB6DE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-3862-1235","first_name":"Julia M","last_name":"Michalska","full_name":"Michalska, Julia M"},{"full_name":"Lyudchik, Julia","first_name":"Julia","last_name":"Lyudchik","id":"46E28B80-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Velicky, Philipp","orcid":"0000-0002-2340-7431","id":"39BDC62C-F248-11E8-B48F-1D18A9856A87","last_name":"Velicky","first_name":"Philipp"},{"full_name":"Korinkova, Hana","first_name":"Hana","last_name":"Korinkova","id":"ee3cb6ca-ec98-11ea-ae11-ff703e2254ed"},{"last_name":"Watson","first_name":"Jake","orcid":"0000-0002-8698-3823","id":"63836096-4690-11EA-BD4E-32803DDC885E","full_name":"Watson, Jake"},{"full_name":"Cenameri, Alban","id":"9ac8f577-2357-11eb-997a-e566c5550886","last_name":"Cenameri","first_name":"Alban"},{"full_name":"Sommer, Christoph M","id":"4DF26D8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1216-9105","first_name":"Christoph M","last_name":"Sommer"},{"full_name":"Amberg, Nicole","orcid":"0000-0002-3183-8207","id":"4CD6AAC6-F248-11E8-B48F-1D18A9856A87","last_name":"Amberg","first_name":"Nicole"},{"last_name":"Venturino","first_name":"Alessandro","orcid":"0000-0003-2356-9403","id":"41CB84B2-F248-11E8-B48F-1D18A9856A87","full_name":"Venturino, Alessandro"},{"full_name":"Roessler, Karl","last_name":"Roessler","first_name":"Karl"},{"last_name":"Czech","first_name":"Thomas","full_name":"Czech, Thomas"},{"last_name":"Höftberger","first_name":"Romana","full_name":"Höftberger, Romana"},{"first_name":"Sandra","last_name":"Siegert","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8635-0877","full_name":"Siegert, Sandra"},{"last_name":"Novarino","first_name":"Gaia","orcid":"0000-0002-7673-7178","id":"3E57A680-F248-11E8-B48F-1D18A9856A87","full_name":"Novarino, Gaia"},{"full_name":"Jonas, Peter M","last_name":"Jonas","first_name":"Peter M","orcid":"0000-0001-5001-4804","id":"353C1B58-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Johann G","last_name":"Danzl","id":"42EFD3B6-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8559-3973","full_name":"Danzl, Johann G"}],"related_material":{"link":[{"url":"https://github.com/danzllab/CATS","relation":"software"}],"record":[{"id":"13126","status":"public","relation":"research_data"}]},"date_updated":"2024-02-21T12:18:18Z","date_created":"2023-09-03T22:01:15Z","ec_funded":1,"external_id":{"isi":["001065254200001"]},"oa":1,"main_file_link":[{"url":"https://doi.org/10.1038/s41587-023-01911-8","open_access":"1"}],"isi":1,"quality_controlled":"1","project":[{"_id":"265CB4D0-B435-11E9-9278-68D0E5697425","grant_number":"I03600","call_identifier":"FWF","name":"Optical control of synaptic function via adhesion molecules"},{"name":"Molecular Drug Targets","call_identifier":"FWF","_id":"2548AE96-B435-11E9-9278-68D0E5697425","grant_number":"W1232-B24"},{"_id":"25C5A090-B435-11E9-9278-68D0E5697425","grant_number":"Z00312","name":"The Wittgenstein Prize","call_identifier":"FWF"},{"name":"High content imaging to decode human immune cell interactions in health and allergic disease","_id":"23889792-32DE-11EA-91FC-C7463DDC885E"},{"name":"Probing the Reversibility of Autism Spectrum Disorders by Employing in vivo and in vitro Models","call_identifier":"H2020","_id":"25444568-B435-11E9-9278-68D0E5697425","grant_number":"715508"},{"grant_number":"692692","_id":"25B7EB9E-B435-11E9-9278-68D0E5697425","name":"Biophysics and circuit function of a giant cortical glumatergic synapse","call_identifier":"H2020"},{"name":"International IST Doctoral Program","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385"},{"name":"Synaptic computations of the hippocampal CA3 circuitry","call_identifier":"H2020","_id":"fc2be41b-9c52-11eb-aca3-faa90aa144e9","grant_number":"101026635"}],"doi":"10.1038/s41587-023-01911-8","acknowledged_ssus":[{"_id":"ScienComp"},{"_id":"Bio"},{"_id":"PreCl"},{"_id":"LifeSc"},{"_id":"M-Shop"},{"_id":"E-Lib"}],"language":[{"iso":"eng"}],"month":"08","publication_identifier":{"eissn":["1546-1696"],"issn":["1087-0156"]}},{"type":"research_data","file_date_updated":"2024-02-06T07:21:43Z","abstract":[{"text":"GABAB receptor (GBR) activation inhibits neurotransmitter release in axon terminals in the brain, except in medial habenula (MHb) terminals, which show robust potentiation. However, mechanisms underlying this enigmatic potentiation remain elusive. Here, we report that GBR activation on MHb terminals induces an activity-dependent transition from a facilitating, tonic to a depressing, phasic neurotransmitter release mode. This transition is accompanied by a 4.1-fold increase in readily releasable vesicle pool (RRP) size and a 3.5-fold increase of docked synaptic vesicles at the presynaptic active zone (AZ). Strikingly, tonic and phasic release exhibit distinct coupling distances and are selectively affected by deletion of synaptoporin (SPO) and Ca2+-dependent activator protein for secretion 2 (CAPS2), respectively. SPO modulates augmentation, the short-term plasticity associated with tonic release, and CAPS2 retains the increased RRP for initial responses in phasic response trains. Double pre-embedding immunolabeling confirmed the co-localization of CAPS2 and SPO inside the same terminal. The cytosolic protein CAPS2 showed a synaptic vesicle (SV)-associated distribution similar to the vesicular transmembrane protein SPO. A newly developed “Flash and Freeze-fracture” method revealed the release of SPO-associated vesicles in both tonic and phasic modes and activity-dependent recruitment of CAPS2 to the AZ during phasic release, which lasted several minutes. Overall, these results indicate that GBR activation translocates CAPS2 to the AZ along with the fusion of CAPS2-associated SVs, contributing to a persistent RRP increase. Thus, we discovered structural and molecular mechanisms underlying tonic and phasic neurotransmitter release and their transition by GBR activation in MHb terminals.","lang":"eng"}],"license":"https://creativecommons.org/licenses/by-nc/4.0/","_id":"13173","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","year":"2023","publisher":"Institute of Science and Technology Austria","department":[{"_id":"RySh"}],"status":"public","title":"Transition from tonic to phasic neurotransmitter release by presynaptic GABAB receptor activation in medial habenula terminals","ddc":["571"],"related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"15084"}]},"author":[{"first_name":"Ryuichi","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi"}],"oa_version":"Published Version","file":[{"description":"After review an updated version of the data is provided","file_name":"Raw data for Koppensteiner et al.zip","access_level":"closed","creator":"shigemot","content_type":"application/x-zip-compressed","file_size":542873672,"file_id":"13174","title":"Outdated Version","relation":"main_file","date_created":"2023-06-29T13:11:22Z","date_updated":"2023-11-17T14:30:44Z","checksum":"ed59170869ba621f89f7c1894092192f"},{"date_updated":"2023-11-17T14:13:02Z","date_created":"2023-11-17T14:13:02Z","success":1,"checksum":"c07860eb82b4d367245f1b589fe5c250","file_id":"14550","relation":"main_file","creator":"patrickd","content_type":"application/vnd.openxmlformats-officedocument.spreadsheetml.sheet","file_size":915079,"file_name":"11-17-23 Updated Koppensteiner et al. raw data.xlsx","access_level":"open_access"},{"creator":"dernst","content_type":"application/x-zip-compressed","file_size":544868924,"access_level":"open_access","file_name":"EM_Images.zip","success":1,"checksum":"abf84b1699edac4349dc3a92d466fb7b","date_created":"2024-02-06T07:21:43Z","date_updated":"2024-02-06T07:21:43Z","file_id":"14942","relation":"main_file"}],"date_created":"2023-06-29T13:16:42Z","date_updated":"2024-03-12T13:44:18Z","keyword":["medial habenula","GABAB receptor","vesicle release","Flash and Freeze","Flash and Freeze-fracture"],"article_processing_charge":"No","has_accepted_license":"1","month":"07","day":"29","tmp":{"name":"Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc/4.0/legalcode","image":"/images/cc_by_nc.png","short":"CC BY-NC (4.0)"},"citation":{"ama":"Shigemoto R. Transition from tonic to phasic neurotransmitter release by presynaptic GABAB receptor activation in medial habenula terminals. 2023. doi:10.15479/AT:ISTA:13173","ista":"Shigemoto R. 2023. Transition from tonic to phasic neurotransmitter release by presynaptic GABAB receptor activation in medial habenula terminals, Institute of Science and Technology Austria, 10.15479/AT:ISTA:13173.","ieee":"R. Shigemoto, “Transition from tonic to phasic neurotransmitter release by presynaptic GABAB receptor activation in medial habenula terminals.” Institute of Science and Technology Austria, 2023.","apa":"Shigemoto, R. (2023). Transition from tonic to phasic neurotransmitter release by presynaptic GABAB receptor activation in medial habenula terminals. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:13173","mla":"Shigemoto, Ryuichi. Transition from Tonic to Phasic Neurotransmitter Release by Presynaptic GABAB Receptor Activation in Medial Habenula Terminals. Institute of Science and Technology Austria, 2023, doi:10.15479/AT:ISTA:13173.","short":"R. Shigemoto, (2023).","chicago":"Shigemoto, Ryuichi. “Transition from Tonic to Phasic Neurotransmitter Release by Presynaptic GABAB Receptor Activation in Medial Habenula Terminals.” Institute of Science and Technology Austria, 2023. https://doi.org/10.15479/AT:ISTA:13173."},"oa":1,"doi":"10.15479/AT:ISTA:13173","date_published":"2023-07-29T00:00:00Z"},{"scopus_import":"1","has_accepted_license":"1","article_processing_charge":"No","day":"24","article_type":"original","citation":{"ista":"Eguchi K, Montanaro-Punzengruber J-C, Le Monnier E, Shigemoto R. 2022. The number and distinct clustering patterns of voltage-gated Calcium channels in nerve terminals. Frontiers in Neuroanatomy. 16, 846615.","ieee":"K. Eguchi, J.-C. Montanaro-Punzengruber, E. Le Monnier, and R. Shigemoto, “The number and distinct clustering patterns of voltage-gated Calcium channels in nerve terminals,” Frontiers in Neuroanatomy, vol. 16. Frontiers, 2022.","apa":"Eguchi, K., Montanaro-Punzengruber, J.-C., Le Monnier, E., & Shigemoto, R. (2022). The number and distinct clustering patterns of voltage-gated Calcium channels in nerve terminals. Frontiers in Neuroanatomy. Frontiers. https://doi.org/10.3389/fnana.2022.846615","ama":"Eguchi K, Montanaro-Punzengruber J-C, Le Monnier E, Shigemoto R. The number and distinct clustering patterns of voltage-gated Calcium channels in nerve terminals. Frontiers in Neuroanatomy. 2022;16. doi:10.3389/fnana.2022.846615","chicago":"Eguchi, Kohgaku, Jacqueline-Claire Montanaro-Punzengruber, Elodie Le Monnier, and Ryuichi Shigemoto. “The Number and Distinct Clustering Patterns of Voltage-Gated Calcium Channels in Nerve Terminals.” Frontiers in Neuroanatomy. Frontiers, 2022. https://doi.org/10.3389/fnana.2022.846615.","mla":"Eguchi, Kohgaku, et al. “The Number and Distinct Clustering Patterns of Voltage-Gated Calcium Channels in Nerve Terminals.” Frontiers in Neuroanatomy, vol. 16, 846615, Frontiers, 2022, doi:10.3389/fnana.2022.846615.","short":"K. Eguchi, J.-C. Montanaro-Punzengruber, E. Le Monnier, R. Shigemoto, Frontiers in Neuroanatomy 16 (2022)."},"publication":"Frontiers in Neuroanatomy","date_published":"2022-02-24T00:00:00Z","type":"journal_article","abstract":[{"lang":"eng","text":"Upon the arrival of action potentials at nerve terminals, neurotransmitters are released from synaptic vesicles (SVs) by exocytosis. CaV2.1, 2.2, and 2.3 are the major subunits of the voltage-gated calcium channel (VGCC) responsible for increasing intraterminal calcium levels and triggering SV exocytosis in the central nervous system (CNS) synapses. The two-dimensional analysis of CaV2 distributions using sodium dodecyl sulfate (SDS)-digested freeze-fracture replica labeling (SDS-FRL) has revealed their numbers, densities, and nanoscale clustering patterns in individual presynaptic active zones. The variation in these properties affects the coupling of VGCCs with calcium sensors on SVs, synaptic efficacy, and temporal precision of transmission. In this study, we summarize how the morphological parameters of CaV2 distribution obtained using SDS-FRL differ depending on the different types of synapses and could correspond to functional properties in synaptic transmission."}],"intvolume":" 16","status":"public","title":"The number and distinct clustering patterns of voltage-gated Calcium channels in nerve terminals","ddc":["570"],"_id":"10890","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa_version":"Published Version","file":[{"relation":"main_file","file_id":"10911","checksum":"51ec9b90e7da919e22c01a15489eaacd","success":1,"date_created":"2022-03-21T09:41:19Z","date_updated":"2022-03-21T09:41:19Z","access_level":"open_access","file_name":"2022_FrontiersNeuroanatomy_Eguchi.pdf","content_type":"application/pdf","file_size":2416395,"creator":"dernst"}],"publication_identifier":{"eissn":["16625129"]},"month":"02","project":[{"name":"In situ analysis of single channel subunit composition in neurons: physiological implication in synaptic plasticity and behaviour","call_identifier":"H2020","grant_number":"694539","_id":"25CA28EA-B435-11E9-9278-68D0E5697425"},{"_id":"05970B30-7A3F-11EA-A408-12923DDC885E","grant_number":"I04638","name":"LGI1 antibody-induced pathophysiology in synapses"}],"isi":1,"quality_controlled":"1","oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"external_id":{"pmid":["35280978"],"isi":["000766662700001"]},"language":[{"iso":"eng"}],"doi":"10.3389/fnana.2022.846615","article_number":"846615","ec_funded":1,"file_date_updated":"2022-03-21T09:41:19Z","department":[{"_id":"RySh"}],"publisher":"Frontiers","publication_status":"published","pmid":1,"acknowledgement":"This work was supported by the European Research Council advanced grant No. 694539 and the joint German-Austrian DFG and FWF project SYNABS (FWF: I-4638-B) to RS.\r\nThe authors thank Walter Kaufmann for his critical comments on the manuscript.","year":"2022","volume":16,"date_updated":"2023-08-03T06:07:18Z","date_created":"2022-03-20T23:01:39Z","author":[{"full_name":"Eguchi, Kohgaku","id":"2B7846DC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-6170-2546","first_name":"Kohgaku","last_name":"Eguchi"},{"full_name":"Montanaro-Punzengruber, Jacqueline-Claire","id":"3786AB44-F248-11E8-B48F-1D18A9856A87","last_name":"Montanaro-Punzengruber","first_name":"Jacqueline-Claire"},{"id":"3B59276A-F248-11E8-B48F-1D18A9856A87","last_name":"Le Monnier","first_name":"Elodie","full_name":"Le Monnier, Elodie"},{"first_name":"Ryuichi","last_name":"Shigemoto","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8761-9444","full_name":"Shigemoto, Ryuichi"}]}]