---
_id: '652'
abstract:
- lang: eng
text: 'We present an approach that enables robots to self-organize their sensorimotor
behavior from scratch without providing specific information about neither the
robot nor its environment. This is achieved by a simple neural control law that
increases the consistency between external sensor dynamics and internal neural
dynamics of the utterly simple controller. In this way, the embodiment and the
agent-environment coupling are the only source of individual development. We show
how an anthropomorphic tendon driven arm-shoulder system develops different behaviors
depending on that coupling. For instance: Given a bottle half-filled with water,
the arm starts to shake it, driven by the physical response of the water. When
attaching a brush, the arm can be manipulated into wiping a table, and when connected
to a revolvable wheel it finds out how to rotate it. Thus, the robot may be said
to discover the affordances of the world. When allowing two (simulated) humanoid
robots to interact physically, they engage into a joint behavior development leading
to, for instance, spontaneous cooperation. More social effects are observed if
the robots can visually perceive each other. Although, as an observer, it is tempting
to attribute an apparent intentionality, there is nothing of the kind put in.
As a conclusion, we argue that emergent behavior may be much less rooted in explicit
intentions, internal motivations, or specific reward systems than is commonly
believed.'
article_number: '7846789'
author:
- first_name: Ralf
full_name: Der, Ralf
last_name: Der
- first_name: Georg S
full_name: Martius, Georg S
id: 3A276B68-F248-11E8-B48F-1D18A9856A87
last_name: Martius
citation:
ama: 'Der R, Martius GS. Dynamical self consistency leads to behavioral development
and emergent social interactions in robots. In: IEEE; 2017. doi:10.1109/DEVLRN.2016.7846789'
apa: 'Der, R., & Martius, G. S. (2017). Dynamical self consistency leads to
behavioral development and emergent social interactions in robots. Presented at
the ICDL EpiRob: International Conference on Development and Learning and Epigenetic
Robotics , Cergy-Pontoise, France: IEEE. https://doi.org/10.1109/DEVLRN.2016.7846789'
chicago: Der, Ralf, and Georg S Martius. “Dynamical Self Consistency Leads to Behavioral
Development and Emergent Social Interactions in Robots.” IEEE, 2017. https://doi.org/10.1109/DEVLRN.2016.7846789.
ieee: 'R. Der and G. S. Martius, “Dynamical self consistency leads to behavioral
development and emergent social interactions in robots,” presented at the ICDL
EpiRob: International Conference on Development and Learning and Epigenetic Robotics
, Cergy-Pontoise, France, 2017.'
ista: 'Der R, Martius GS. 2017. Dynamical self consistency leads to behavioral development
and emergent social interactions in robots. ICDL EpiRob: International Conference
on Development and Learning and Epigenetic Robotics , 7846789.'
mla: Der, Ralf, and Georg S. Martius. Dynamical Self Consistency Leads to Behavioral
Development and Emergent Social Interactions in Robots. 7846789, IEEE, 2017,
doi:10.1109/DEVLRN.2016.7846789.
short: R. Der, G.S. Martius, in:, IEEE, 2017.
conference:
end_date: 2016-09-22
location: Cergy-Pontoise, France
name: 'ICDL EpiRob: International Conference on Development and Learning and Epigenetic
Robotics '
start_date: 2016-09-19
date_created: 2018-12-11T11:47:43Z
date_published: 2017-02-07T00:00:00Z
date_updated: 2021-01-12T08:07:51Z
day: '07'
department:
- _id: ChLa
- _id: GaTk
doi: 10.1109/DEVLRN.2016.7846789
language:
- iso: eng
month: '02'
oa_version: None
publication_identifier:
isbn:
- 978-150905069-7
publication_status: published
publisher: IEEE
publist_id: '7100'
quality_controlled: '1'
scopus_import: 1
status: public
title: Dynamical self consistency leads to behavioral development and emergent social
interactions in robots
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2017'
...
---
_id: '651'
abstract:
- lang: eng
text: "Superhydrophobic surfaces reduce the frictional drag between water and solid
materials, but this effect is often temporary. The realization of sustained drag
reduction has applications for water vehicles and pipeline flows.\r\n\r\n"
author:
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
citation:
ama: 'Hof B. Fluid dynamics: Water flows out of touch. Nature. 2017;541(7636):161-162.
doi:10.1038/541161a'
apa: 'Hof, B. (2017). Fluid dynamics: Water flows out of touch. Nature. Nature
Publishing Group. https://doi.org/10.1038/541161a'
chicago: 'Hof, Björn. “Fluid Dynamics: Water Flows out of Touch.” Nature.
Nature Publishing Group, 2017. https://doi.org/10.1038/541161a.'
ieee: 'B. Hof, “Fluid dynamics: Water flows out of touch,” Nature, vol. 541,
no. 7636. Nature Publishing Group, pp. 161–162, 2017.'
ista: 'Hof B. 2017. Fluid dynamics: Water flows out of touch. Nature. 541(7636),
161–162.'
mla: 'Hof, Björn. “Fluid Dynamics: Water Flows out of Touch.” Nature, vol.
541, no. 7636, Nature Publishing Group, 2017, pp. 161–62, doi:10.1038/541161a.'
short: B. Hof, Nature 541 (2017) 161–162.
date_created: 2018-12-11T11:47:43Z
date_published: 2017-01-11T00:00:00Z
date_updated: 2021-01-12T08:07:49Z
day: '11'
department:
- _id: BjHo
doi: 10.1038/541161a
intvolume: ' 541'
issue: '7636'
language:
- iso: eng
month: '01'
oa_version: None
page: 161 - 162
publication: Nature
publication_identifier:
issn:
- '00280836'
publication_status: published
publisher: Nature Publishing Group
publist_id: '7116'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'Fluid dynamics: Water flows out of touch'
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 541
year: '2017'
...
---
_id: '653'
abstract:
- lang: eng
text: The extent of heterogeneity among driver gene mutations present in naturally
occurring metastases - that is, treatment-naive metastatic disease - is largely
unknown. To address this issue, we carried out 60× whole-genome sequencing of
26 metastases from four patients with pancreatic cancer. We found that identical
mutations in known driver genes were present in every metastatic lesion for each
patient studied. Passenger gene mutations, which do not have known or predicted
functional consequences, accounted for all intratumoral heterogeneity. Even with
respect to these passenger mutations, our analysis suggests that the genetic similarity
among the founding cells of metastases was higher than that expected for any two
cells randomly taken from a normal tissue. The uniformity of known driver gene
mutations among metastases in the same patient has critical and encouraging implications
for the success of future targeted therapies in advanced-stage disease.
acknowledgement: 'We thank the Memorial Sloan Kettering Cancer Center Molecular Cytology
core facility for immunohistochemistry staining. This work was supported by Office
of Naval Research grant N00014-16-1-2914, the Bill and Melinda Gates Foundation
(OPP1148627), and a gift from B. Wu and E. Larson (M.A.N.), National Institutes
of Health grants CA179991 (C.A.I.-D. and I.B.), F31 CA180682 (A.P.M.-M.), CA43460
(B.V.), and P50 CA62924, the Monastra Foundation, the Virginia and D.K. Ludwig Fund
for Cancer Research, the Lustgarten Foundation for Pancreatic Cancer Research, the
Sol Goldman Center for Pancreatic Cancer Research, the Sol Goldman Sequencing Center,
ERC Start grant 279307: Graph Games (J.G.R., D.K., and C.K.), Austrian Science Fund
(FWF) grant P23499-N23 (J.G.R., D.K., and C.K.), and FWF NFN grant S11407-N23 RiSE/SHiNE
(J.G.R., D.K., and C.K.).'
article_processing_charge: No
article_type: original
author:
- first_name: Alvin
full_name: Makohon Moore, Alvin
last_name: Makohon Moore
- first_name: Ming
full_name: Zhang, Ming
last_name: Zhang
- first_name: Johannes
full_name: Reiter, Johannes
id: 4A918E98-F248-11E8-B48F-1D18A9856A87
last_name: Reiter
orcid: 0000-0002-0170-7353
- first_name: Ivana
full_name: Božić, Ivana
last_name: Božić
- first_name: Benjamin
full_name: Allen, Benjamin
last_name: Allen
- first_name: Deepanjan
full_name: Kundu, Deepanjan
id: 1d4c0f4f-e8a3-11ec-a351-e36772758c45
last_name: Kundu
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Fay
full_name: Wong, Fay
last_name: Wong
- first_name: Yuchen
full_name: Jiao, Yuchen
last_name: Jiao
- first_name: Zachary
full_name: Kohutek, Zachary
last_name: Kohutek
- first_name: Jungeui
full_name: Hong, Jungeui
last_name: Hong
- first_name: Marc
full_name: Attiyeh, Marc
last_name: Attiyeh
- first_name: Breanna
full_name: Javier, Breanna
last_name: Javier
- first_name: Laura
full_name: Wood, Laura
last_name: Wood
- first_name: Ralph
full_name: Hruban, Ralph
last_name: Hruban
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
- first_name: Nickolas
full_name: Papadopoulos, Nickolas
last_name: Papadopoulos
- first_name: Kenneth
full_name: Kinzler, Kenneth
last_name: Kinzler
- first_name: Bert
full_name: Vogelstein, Bert
last_name: Vogelstein
- first_name: Christine
full_name: Iacobuzio Donahue, Christine
last_name: Iacobuzio Donahue
citation:
ama: Makohon Moore A, Zhang M, Reiter J, et al. Limited heterogeneity of known driver
gene mutations among the metastases of individual patients with pancreatic cancer.
Nature Genetics. 2017;49(3):358-366. doi:10.1038/ng.3764
apa: Makohon Moore, A., Zhang, M., Reiter, J., Božić, I., Allen, B., Kundu, D.,
… Iacobuzio Donahue, C. (2017). Limited heterogeneity of known driver gene mutations
among the metastases of individual patients with pancreatic cancer. Nature
Genetics. Nature Publishing Group. https://doi.org/10.1038/ng.3764
chicago: Makohon Moore, Alvin, Ming Zhang, Johannes Reiter, Ivana Božić, Benjamin
Allen, Deepanjan Kundu, Krishnendu Chatterjee, et al. “Limited Heterogeneity of
Known Driver Gene Mutations among the Metastases of Individual Patients with Pancreatic
Cancer.” Nature Genetics. Nature Publishing Group, 2017. https://doi.org/10.1038/ng.3764.
ieee: A. Makohon Moore et al., “Limited heterogeneity of known driver gene
mutations among the metastases of individual patients with pancreatic cancer,”
Nature Genetics, vol. 49, no. 3. Nature Publishing Group, pp. 358–366,
2017.
ista: Makohon Moore A, Zhang M, Reiter J, Božić I, Allen B, Kundu D, Chatterjee
K, Wong F, Jiao Y, Kohutek Z, Hong J, Attiyeh M, Javier B, Wood L, Hruban R, Nowak
M, Papadopoulos N, Kinzler K, Vogelstein B, Iacobuzio Donahue C. 2017. Limited
heterogeneity of known driver gene mutations among the metastases of individual
patients with pancreatic cancer. Nature Genetics. 49(3), 358–366.
mla: Makohon Moore, Alvin, et al. “Limited Heterogeneity of Known Driver Gene Mutations
among the Metastases of Individual Patients with Pancreatic Cancer.” Nature
Genetics, vol. 49, no. 3, Nature Publishing Group, 2017, pp. 358–66, doi:10.1038/ng.3764.
short: A. Makohon Moore, M. Zhang, J. Reiter, I. Božić, B. Allen, D. Kundu, K. Chatterjee,
F. Wong, Y. Jiao, Z. Kohutek, J. Hong, M. Attiyeh, B. Javier, L. Wood, R. Hruban,
M. Nowak, N. Papadopoulos, K. Kinzler, B. Vogelstein, C. Iacobuzio Donahue, Nature
Genetics 49 (2017) 358–366.
date_created: 2018-12-11T11:47:43Z
date_published: 2017-03-01T00:00:00Z
date_updated: 2022-06-10T09:55:08Z
day: '01'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1038/ng.3764
ec_funded: 1
external_id:
pmid:
- '28092682'
file:
- access_level: open_access
checksum: e442dc3b7420a36ec805e9bb45cc1a2e
content_type: application/pdf
creator: dernst
date_created: 2019-11-19T08:13:50Z
date_updated: 2020-07-14T12:47:33Z
file_id: '7050'
file_name: 2017_NatureGenetics_Makohon.pdf
file_size: 908099
relation: main_file
file_date_updated: 2020-07-14T12:47:33Z
has_accepted_license: '1'
intvolume: ' 49'
issue: '3'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 358 - 366
pmid: 1
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
publication: Nature Genetics
publication_identifier:
issn:
- '10614036'
publication_status: published
publisher: Nature Publishing Group
publist_id: '7092'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Limited heterogeneity of known driver gene mutations among the metastases of
individual patients with pancreatic cancer
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 49
year: '2017'
...
---
_id: '6527'
abstract:
- lang: eng
text: "A memory-hard function (MHF) ƒn with parameter n can be computed in sequential
time and space n. Simultaneously, a high amortized parallel area-time complexity
(aAT) is incurred per evaluation. In practice, MHFs are used to limit the rate
at which an adversary (using a custom computational device) can evaluate a security
sensitive function that still occasionally needs to be evaluated by honest users
(using an off-the-shelf general purpose device). The most prevalent examples of
such sensitive functions are Key Derivation Functions (KDFs) and password hashing
algorithms where rate limits help mitigate off-line dictionary attacks. As the
honest users' inputs to these functions are often (low-entropy) passwords special
attention is given to a class of side-channel resistant MHFs called iMHFs.\r\n\r\nEssentially
all iMHFs can be viewed as some mode of operation (making n calls to some round
function) given by a directed acyclic graph (DAG) with very low indegree. Recently,
a combinatorial property of a DAG has been identified (called \"depth-robustness\")
which results in good provable security for an iMHF based on that DAG. Depth-robust
DAGs have also proven useful in other cryptographic applications. Unfortunately,
up till now, all known very depth-robust DAGs are impractically complicated and
little is known about their exact (i.e. non-asymptotic) depth-robustness both
in theory and in practice.\r\n\r\nIn this work we build and analyze (both formally
and empirically) several exceedingly simple and efficient to navigate practical
DAGs for use in iMHFs and other applications. For each DAG we:\r\n*Prove that
their depth-robustness is asymptotically maximal.\r\n*Prove bounds of at least
3 orders of magnitude better on their exact depth-robustness compared to known
bounds for other practical iMHF.\r\n*Implement and empirically evaluate their
depth-robustness and aAT against a variety of state-of-the art (and several new)
depth-reduction and low aAT attacks. \r\nWe find that, against all attacks, the
new DAGs perform significantly better in practice than Argon2i, the most widely
deployed iMHF in practice.\r\n\r\nAlong the way we also improve the best known
empirical attacks on the aAT of Argon2i by implementing and testing several heuristic
versions of a (hitherto purely theoretical) depth-reduction attack. Finally, we
demonstrate practicality of our constructions by modifying the Argon2i code base
to use one of the new high aAT DAGs. Experimental benchmarks on a standard off-the-shelf
CPU show that the new modifications do not adversely affect the impressive throughput
of Argon2i (despite seemingly enjoying significantly higher aAT).\r\n"
author:
- first_name: Joel F
full_name: Alwen, Joel F
id: 2A8DFA8C-F248-11E8-B48F-1D18A9856A87
last_name: Alwen
- first_name: Jeremiah
full_name: Blocki, Jeremiah
last_name: Blocki
- first_name: Ben
full_name: Harsha, Ben
last_name: Harsha
citation:
ama: 'Alwen JF, Blocki J, Harsha B. Practical graphs for optimal side-channel resistant
memory-hard functions. In: Proceedings of the 2017 ACM SIGSAC Conference on
Computer and Communications Security. ACM Press; 2017:1001-1017. doi:10.1145/3133956.3134031'
apa: 'Alwen, J. F., Blocki, J., & Harsha, B. (2017). Practical graphs for optimal
side-channel resistant memory-hard functions. In Proceedings of the 2017 ACM
SIGSAC Conference on Computer and Communications Security (pp. 1001–1017).
Dallas, TX, USA: ACM Press. https://doi.org/10.1145/3133956.3134031'
chicago: Alwen, Joel F, Jeremiah Blocki, and Ben Harsha. “Practical Graphs for Optimal
Side-Channel Resistant Memory-Hard Functions.” In Proceedings of the 2017 ACM
SIGSAC Conference on Computer and Communications Security, 1001–17. ACM Press,
2017. https://doi.org/10.1145/3133956.3134031.
ieee: J. F. Alwen, J. Blocki, and B. Harsha, “Practical graphs for optimal side-channel
resistant memory-hard functions,” in Proceedings of the 2017 ACM SIGSAC Conference
on Computer and Communications Security, Dallas, TX, USA, 2017, pp. 1001–1017.
ista: 'Alwen JF, Blocki J, Harsha B. 2017. Practical graphs for optimal side-channel
resistant memory-hard functions. Proceedings of the 2017 ACM SIGSAC Conference
on Computer and Communications Security. CCS: Conference on Computer and Communications
Security, 1001–1017.'
mla: Alwen, Joel F., et al. “Practical Graphs for Optimal Side-Channel Resistant
Memory-Hard Functions.” Proceedings of the 2017 ACM SIGSAC Conference on Computer
and Communications Security, ACM Press, 2017, pp. 1001–17, doi:10.1145/3133956.3134031.
short: J.F. Alwen, J. Blocki, B. Harsha, in:, Proceedings of the 2017 ACM SIGSAC
Conference on Computer and Communications Security, ACM Press, 2017, pp. 1001–1017.
conference:
end_date: 2017-11-03
location: Dallas, TX, USA
name: 'CCS: Conference on Computer and Communications Security'
start_date: 2017-10-30
date_created: 2019-06-06T13:21:29Z
date_published: 2017-10-30T00:00:00Z
date_updated: 2021-01-12T08:07:53Z
day: '30'
department:
- _id: KrPi
doi: 10.1145/3133956.3134031
ec_funded: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://eprint.iacr.org/2017/443
month: '10'
oa: 1
oa_version: Submitted Version
page: 1001-1017
project:
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '682815'
name: Teaching Old Crypto New Tricks
publication: Proceedings of the 2017 ACM SIGSAC Conference on Computer and Communications
Security
publication_identifier:
isbn:
- '9781450349468'
publication_status: published
publisher: ACM Press
quality_controlled: '1'
scopus_import: 1
status: public
title: Practical graphs for optimal side-channel resistant memory-hard functions
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2017'
...
---
_id: '654'
abstract:
- lang: eng
text: In November 2016, developmental biologists, synthetic biologists and engineers
gathered in Paris for a meeting called ‘Engineering the embryo’. The participants
shared an interest in exploring how synthetic systems can reveal new principles
of embryonic development, and how the in vitro manipulation and modeling of development
using stem cells can be used to integrate ideas and expertise from physics, developmental
biology and tissue engineering. As we review here, the conference pinpointed some
of the challenges arising at the intersection of these fields, along with great
enthusiasm for finding new approaches and collaborations.
author:
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Nicolas
full_name: Rivron, Nicolas
last_name: Rivron
citation:
ama: Kicheva A, Rivron N. Creating to understand – developmental biology meets engineering
in Paris. Development. 2017;144(5):733-736. doi:10.1242/dev.144915
apa: Kicheva, A., & Rivron, N. (2017). Creating to understand – developmental
biology meets engineering in Paris. Development. Company of Biologists.
https://doi.org/10.1242/dev.144915
chicago: Kicheva, Anna, and Nicolas Rivron. “Creating to Understand – Developmental
Biology Meets Engineering in Paris.” Development. Company of Biologists,
2017. https://doi.org/10.1242/dev.144915.
ieee: A. Kicheva and N. Rivron, “Creating to understand – developmental biology
meets engineering in Paris,” Development, vol. 144, no. 5. Company of Biologists,
pp. 733–736, 2017.
ista: Kicheva A, Rivron N. 2017. Creating to understand – developmental biology
meets engineering in Paris. Development. 144(5), 733–736.
mla: Kicheva, Anna, and Nicolas Rivron. “Creating to Understand – Developmental
Biology Meets Engineering in Paris.” Development, vol. 144, no. 5, Company
of Biologists, 2017, pp. 733–36, doi:10.1242/dev.144915.
short: A. Kicheva, N. Rivron, Development 144 (2017) 733–736.
date_created: 2018-12-11T11:47:44Z
date_published: 2017-03-01T00:00:00Z
date_updated: 2021-01-12T08:07:54Z
day: '01'
ddc:
- '571'
department:
- _id: AnKi
doi: 10.1242/dev.144915
ec_funded: 1
file:
- access_level: open_access
checksum: eef22a0f42a55b232cb2d1188a2322cb
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:20Z
date_updated: 2020-07-14T12:47:33Z
file_id: '5139'
file_name: IST-2018-987-v1+1_2017_KichevaRivron__Creating_to.pdf
file_size: 228206
relation: main_file
file_date_updated: 2020-07-14T12:47:33Z
has_accepted_license: '1'
intvolume: ' 144'
issue: '5'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Submitted Version
page: 733 - 736
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
call_identifier: H2020
grant_number: '680037'
name: Coordination of Patterning And Growth In the Spinal Cord
publication: Development
publication_identifier:
issn:
- '09501991'
publication_status: published
publisher: Company of Biologists
publist_id: '7089'
pubrep_id: '987'
quality_controlled: '1'
scopus_import: 1
status: public
title: Creating to understand – developmental biology meets engineering in Paris
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 144
year: '2017'
...
---
_id: '6526'
abstract:
- lang: eng
text: 'This paper studies the complexity of estimating Rényi divergences of discrete
distributions: p observed from samples and the baseline distribution q known a
priori. Extending the results of Acharya et al. (SODA''15) on estimating Rényi
entropy, we present improved estimation techniques together with upper and lower
bounds on the sample complexity. We show that, contrarily to estimating Rényi
entropy where a sublinear (in the alphabet size) number of samples suffices, the
sample complexity is heavily dependent on events occurring unlikely in q, and
is unbounded in general (no matter what an estimation technique is used). For
any divergence of integer order bigger than 1, we provide upper and lower bounds
on the number of samples dependent on probabilities of p and q (the lower bounds
hold for non-integer orders as well). We conclude that the worst-case sample complexity
is polynomial in the alphabet size if and only if the probabilities of q are non-negligible.
This gives theoretical insights into heuristics used in the applied literature
to handle numerical instability, which occurs for small probabilities of q. Our
result shows that they should be handled with care not only because of numerical
issues, but also because of a blow up in the sample complexity.'
article_number: '8006529'
author:
- first_name: Maciej
full_name: Skórski, Maciej
id: EC09FA6A-02D0-11E9-8223-86B7C91467DD
last_name: Skórski
citation:
ama: 'Skórski M. On the complexity of estimating Rènyi divergences. In: 2017
IEEE International Symposium on Information Theory (ISIT). IEEE; 2017. doi:10.1109/isit.2017.8006529'
apa: 'Skórski, M. (2017). On the complexity of estimating Rènyi divergences. In
2017 IEEE International Symposium on Information Theory (ISIT). Aachen,
Germany: IEEE. https://doi.org/10.1109/isit.2017.8006529'
chicago: Skórski, Maciej. “On the Complexity of Estimating Rènyi Divergences.” In
2017 IEEE International Symposium on Information Theory (ISIT). IEEE, 2017.
https://doi.org/10.1109/isit.2017.8006529.
ieee: M. Skórski, “On the complexity of estimating Rènyi divergences,” in 2017
IEEE International Symposium on Information Theory (ISIT), Aachen, Germany,
2017.
ista: 'Skórski M. 2017. On the complexity of estimating Rènyi divergences. 2017
IEEE International Symposium on Information Theory (ISIT). ISIT: International
Symposium on Information Theory, 8006529.'
mla: Skórski, Maciej. “On the Complexity of Estimating Rènyi Divergences.” 2017
IEEE International Symposium on Information Theory (ISIT), 8006529, IEEE,
2017, doi:10.1109/isit.2017.8006529.
short: M. Skórski, in:, 2017 IEEE International Symposium on Information Theory
(ISIT), IEEE, 2017.
conference:
end_date: 2017-06-30
location: Aachen, Germany
name: 'ISIT: International Symposium on Information Theory'
start_date: 2017-06-25
date_created: 2019-06-06T12:53:09Z
date_published: 2017-08-09T00:00:00Z
date_updated: 2021-01-12T08:07:53Z
day: '09'
department:
- _id: KrPi
doi: 10.1109/isit.2017.8006529
ec_funded: 1
external_id:
arxiv:
- '1702.01666'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1702.01666
month: '08'
oa: 1
oa_version: Preprint
project:
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '682815'
name: Teaching Old Crypto New Tricks
publication: 2017 IEEE International Symposium on Information Theory (ISIT)
publication_identifier:
isbn:
- '9781509040964'
publication_status: published
publisher: IEEE
quality_controlled: '1'
scopus_import: 1
status: public
title: On the complexity of estimating Rènyi divergences
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2017'
...
---
_id: '655'
abstract:
- lang: eng
text: 'The bacterial flagellum is a self-assembling nanomachine. The external flagellar
filament, several times longer than a bacterial cell body, is made of a few tens
of thousands subunits of a single protein: flagellin. A fundamental problem concerns
the molecular mechanism of how the flagellum grows outside the cell, where no
discernible energy source is available. Here, we monitored the dynamic assembly
of individual flagella using in situ labelling and real-time immunostaining of
elongating flagellar filaments. We report that the rate of flagellum growth, initially
~1,700 amino acids per second, decreases with length and that the previously proposed
chain mechanism does not contribute to the filament elongation dynamics. Inhibition
of the proton motive force-dependent export apparatus revealed a major contribution
of substrate injection in driving filament elongation. The combination of experimental
and mathematical evidence demonstrates that a simple, injection-diffusion mechanism
controls bacterial flagella growth outside the cell.'
article_number: e23136
author:
- first_name: Thibaud
full_name: Renault, Thibaud
last_name: Renault
- first_name: Anthony
full_name: Abraham, Anthony
last_name: Abraham
- first_name: Tobias
full_name: Bergmiller, Tobias
id: 2C471CFA-F248-11E8-B48F-1D18A9856A87
last_name: Bergmiller
orcid: 0000-0001-5396-4346
- first_name: Guillaume
full_name: Paradis, Guillaume
last_name: Paradis
- first_name: Simon
full_name: Rainville, Simon
last_name: Rainville
- first_name: Emmanuelle
full_name: Charpentier, Emmanuelle
last_name: Charpentier
- first_name: Calin C
full_name: Guet, Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
- first_name: Yuhai
full_name: Tu, Yuhai
last_name: Tu
- first_name: Keiichi
full_name: Namba, Keiichi
last_name: Namba
- first_name: James
full_name: Keener, James
last_name: Keener
- first_name: Tohru
full_name: Minamino, Tohru
last_name: Minamino
- first_name: Marc
full_name: Erhardt, Marc
last_name: Erhardt
citation:
ama: Renault T, Abraham A, Bergmiller T, et al. Bacterial flagella grow through
an injection diffusion mechanism. eLife. 2017;6. doi:10.7554/eLife.23136
apa: Renault, T., Abraham, A., Bergmiller, T., Paradis, G., Rainville, S., Charpentier,
E., … Erhardt, M. (2017). Bacterial flagella grow through an injection diffusion
mechanism. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.23136
chicago: Renault, Thibaud, Anthony Abraham, Tobias Bergmiller, Guillaume Paradis,
Simon Rainville, Emmanuelle Charpentier, Calin C Guet, et al. “Bacterial Flagella
Grow through an Injection Diffusion Mechanism.” ELife. eLife Sciences Publications,
2017. https://doi.org/10.7554/eLife.23136.
ieee: T. Renault et al., “Bacterial flagella grow through an injection diffusion
mechanism,” eLife, vol. 6. eLife Sciences Publications, 2017.
ista: Renault T, Abraham A, Bergmiller T, Paradis G, Rainville S, Charpentier E,
Guet CC, Tu Y, Namba K, Keener J, Minamino T, Erhardt M. 2017. Bacterial flagella
grow through an injection diffusion mechanism. eLife. 6, e23136.
mla: Renault, Thibaud, et al. “Bacterial Flagella Grow through an Injection Diffusion
Mechanism.” ELife, vol. 6, e23136, eLife Sciences Publications, 2017, doi:10.7554/eLife.23136.
short: T. Renault, A. Abraham, T. Bergmiller, G. Paradis, S. Rainville, E. Charpentier,
C.C. Guet, Y. Tu, K. Namba, J. Keener, T. Minamino, M. Erhardt, ELife 6 (2017).
date_created: 2018-12-11T11:47:44Z
date_published: 2017-03-06T00:00:00Z
date_updated: 2021-01-12T08:07:55Z
day: '06'
ddc:
- '579'
department:
- _id: CaGu
doi: 10.7554/eLife.23136
file:
- access_level: open_access
checksum: 39e1c3e82ddac83a30422fa72fa1a383
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:08:53Z
date_updated: 2020-07-14T12:47:33Z
file_id: '4716'
file_name: IST-2017-904-v1+1_elife-23136-v2.pdf
file_size: 5520359
relation: main_file
- access_level: open_access
checksum: a6d542253028f52e00aa29739ddffe8f
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:08:54Z
date_updated: 2020-07-14T12:47:33Z
file_id: '4717'
file_name: IST-2017-904-v1+2_elife-23136-figures-v2.pdf
file_size: 11242920
relation: main_file
file_date_updated: 2020-07-14T12:47:33Z
has_accepted_license: '1'
intvolume: ' 6'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: eLife
publication_identifier:
issn:
- 2050084X
publication_status: published
publisher: eLife Sciences Publications
publist_id: '7082'
pubrep_id: '904'
quality_controlled: '1'
scopus_import: 1
status: public
title: Bacterial flagella grow through an injection diffusion mechanism
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2017'
...
---
_id: '657'
abstract:
- lang: eng
text: Plant organs are typically organized into three main tissue layers. The middle
ground tissue layer comprises the majority of the plant body and serves a wide
range of functions, including photosynthesis, selective nutrient uptake and storage,
and gravity sensing. Ground tissue patterning and maintenance in Arabidopsis are
controlled by a well-established gene network revolving around the key regulator
SHORT-ROOT (SHR). In contrast, it is completely unknown how ground tissue identity
is first specified from totipotent precursor cells in the embryo. The plant signaling
molecule auxin, acting through AUXIN RESPONSE FACTOR (ARF) transcription factors,
is critical for embryo patterning. The auxin effector ARF5/MONOPTEROS (MP) acts
both cell-autonomously and noncell-autonomously to control embryonic vascular
tissue formation and root initiation, respectively. Here we show that auxin response
and ARF activity cell-autonomously control the asymmetric division of the first
ground tissue cells. By identifying embryonic target genes, we show that MP transcriptionally
initiates the ground tissue lineage and acts upstream of the regulatory network
that controls ground tissue patterning and maintenance. Strikingly, whereas the
SHR network depends on MP, this MP function is, at least in part, SHR independent.
Our study therefore identifies auxin response as a regulator of ground tissue
specification in the embryonic root, and reveals that ground tissue initiation
and maintenance use different regulators and mechanisms. Moreover, our data provide
a framework for the simultaneous formation of multiple cell types by the same
transcriptional regulator.
author:
- first_name: Barbara
full_name: Möller, Barbara
last_name: Möller
- first_name: Colette
full_name: Ten Hove, Colette
last_name: Ten Hove
- first_name: Daoquan
full_name: Xiang, Daoquan
last_name: Xiang
- first_name: Nerys
full_name: Williams, Nerys
last_name: Williams
- first_name: Lorena
full_name: López, Lorena
last_name: López
- first_name: Saiko
full_name: Yoshida, Saiko
id: 2E46069C-F248-11E8-B48F-1D18A9856A87
last_name: Yoshida
- first_name: Margot
full_name: Smit, Margot
last_name: Smit
- first_name: Raju
full_name: Datla, Raju
last_name: Datla
- first_name: Dolf
full_name: Weijers, Dolf
last_name: Weijers
citation:
ama: Möller B, Ten Hove C, Xiang D, et al. Auxin response cell autonomously controls
ground tissue initiation in the early arabidopsis embryo. PNAS. 2017;114(12):E2533-E2539.
doi:10.1073/pnas.1616493114
apa: Möller, B., Ten Hove, C., Xiang, D., Williams, N., López, L., Yoshida, S.,
… Weijers, D. (2017). Auxin response cell autonomously controls ground tissue
initiation in the early arabidopsis embryo. PNAS. National Academy of Sciences.
https://doi.org/10.1073/pnas.1616493114
chicago: Möller, Barbara, Colette Ten Hove, Daoquan Xiang, Nerys Williams, Lorena
López, Saiko Yoshida, Margot Smit, Raju Datla, and Dolf Weijers. “Auxin Response
Cell Autonomously Controls Ground Tissue Initiation in the Early Arabidopsis Embryo.”
PNAS. National Academy of Sciences, 2017. https://doi.org/10.1073/pnas.1616493114.
ieee: B. Möller et al., “Auxin response cell autonomously controls ground
tissue initiation in the early arabidopsis embryo,” PNAS, vol. 114, no.
12. National Academy of Sciences, pp. E2533–E2539, 2017.
ista: Möller B, Ten Hove C, Xiang D, Williams N, López L, Yoshida S, Smit M, Datla
R, Weijers D. 2017. Auxin response cell autonomously controls ground tissue initiation
in the early arabidopsis embryo. PNAS. 114(12), E2533–E2539.
mla: Möller, Barbara, et al. “Auxin Response Cell Autonomously Controls Ground Tissue
Initiation in the Early Arabidopsis Embryo.” PNAS, vol. 114, no. 12, National
Academy of Sciences, 2017, pp. E2533–39, doi:10.1073/pnas.1616493114.
short: B. Möller, C. Ten Hove, D. Xiang, N. Williams, L. López, S. Yoshida, M. Smit,
R. Datla, D. Weijers, PNAS 114 (2017) E2533–E2539.
date_created: 2018-12-11T11:47:45Z
date_published: 2017-03-21T00:00:00Z
date_updated: 2021-01-12T08:08:02Z
day: '21'
department:
- _id: JiFr
doi: 10.1073/pnas.1616493114
external_id:
pmid:
- '28265057'
intvolume: ' 114'
issue: '12'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5373392/
month: '03'
oa: 1
oa_version: Submitted Version
page: E2533 - E2539
pmid: 1
publication: PNAS
publication_identifier:
issn:
- '00278424'
publication_status: published
publisher: National Academy of Sciences
publist_id: '7076'
quality_controlled: '1'
scopus_import: 1
status: public
title: Auxin response cell autonomously controls ground tissue initiation in the early
arabidopsis embryo
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 114
year: '2017'
...
---
_id: '656'
abstract:
- lang: eng
text: Human neurons transplanted into a mouse model for Alzheimer’s disease show
human-specific vulnerability to β-amyloid plaques and may help to identify new
therapeutic targets.
article_number: eaam9867
author:
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
citation:
ama: Novarino G. Modeling Alzheimer’s disease in mice with human neurons. Science
Translational Medicine. 2017;9(381). doi:10.1126/scitranslmed.aam9867
apa: Novarino, G. (2017). Modeling Alzheimer’s disease in mice with human neurons.
Science Translational Medicine. American Association for the Advancement
of Science. https://doi.org/10.1126/scitranslmed.aam9867
chicago: Novarino, Gaia. “Modeling Alzheimer’s Disease in Mice with Human Neurons.”
Science Translational Medicine. American Association for the Advancement
of Science, 2017. https://doi.org/10.1126/scitranslmed.aam9867.
ieee: G. Novarino, “Modeling Alzheimer’s disease in mice with human neurons,” Science
Translational Medicine, vol. 9, no. 381. American Association for the Advancement
of Science, 2017.
ista: Novarino G. 2017. Modeling Alzheimer’s disease in mice with human neurons.
Science Translational Medicine. 9(381), eaam9867.
mla: Novarino, Gaia. “Modeling Alzheimer’s Disease in Mice with Human Neurons.”
Science Translational Medicine, vol. 9, no. 381, eaam9867, American Association
for the Advancement of Science, 2017, doi:10.1126/scitranslmed.aam9867.
short: G. Novarino, Science Translational Medicine 9 (2017).
date_created: 2018-12-11T11:47:45Z
date_published: 2017-03-15T00:00:00Z
date_updated: 2021-01-12T08:07:59Z
day: '15'
department:
- _id: GaNo
doi: 10.1126/scitranslmed.aam9867
intvolume: ' 9'
issue: '381'
language:
- iso: eng
month: '03'
oa_version: None
publication: Science Translational Medicine
publication_identifier:
issn:
- '19466234'
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '7079'
quality_controlled: '1'
scopus_import: 1
status: public
title: Modeling Alzheimer's disease in mice with human neurons
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2017'
...
---
_id: '658'
abstract:
- lang: eng
text: 'With the accelerated development of robot technologies, control becomes one
of the central themes of research. In traditional approaches, the controller,
by its internal functionality, finds appropriate actions on the basis of specific
objectives for the task at hand. While very successful in many applications, self-organized
control schemes seem to be favored in large complex systems with unknown dynamics
or which are difficult to model. Reasons are the expected scalability, robustness,
and resilience of self-organizing systems. The paper presents a self-learning
neurocontroller based on extrinsic differential plasticity introduced recently,
applying it to an anthropomorphic musculoskeletal robot arm with attached objects
of unknown physical dynamics. The central finding of the paper is the following
effect: by the mere feedback through the internal dynamics of the object, the
robot is learning to relate each of the objects with a very specific sensorimotor
pattern. Specifically, an attached pendulum pilots the arm into a circular motion,
a half-filled bottle produces axis oriented shaking behavior, a wheel is getting
rotated, and wiping patterns emerge automatically in a table-plus-brush setting.
By these object-specific dynamical patterns, the robot may be said to recognize
the object''s identity, or in other words, it discovers dynamical affordances
of objects. Furthermore, when including hand coordinates obtained from a camera,
a dedicated hand-eye coordination self-organizes spontaneously. These phenomena
are discussed from a specific dynamical system perspective. Central is the dedicated
working regime at the border to instability with its potentially infinite reservoir
of (limit cycle) attractors "waiting" to be excited. Besides converging
toward one of these attractors, variate behavior is also arising from a self-induced
attractor morphing driven by the learning rule. We claim that experimental investigations
with this anthropomorphic, self-learning robot not only generate interesting and
potentially useful behaviors, but may also help to better understand what subjective
human muscle feelings are, how they can be rooted in sensorimotor patterns, and
how these concepts may feed back on robotics.'
article_number: '00008'
article_processing_charge: Yes
author:
- first_name: Ralf
full_name: Der, Ralf
last_name: Der
- first_name: Georg S
full_name: Martius, Georg S
id: 3A276B68-F248-11E8-B48F-1D18A9856A87
last_name: Martius
citation:
ama: Der R, Martius GS. Self organized behavior generation for musculoskeletal robots.
Frontiers in Neurorobotics. 2017;11(MAR). doi:10.3389/fnbot.2017.00008
apa: Der, R., & Martius, G. S. (2017). Self organized behavior generation for
musculoskeletal robots. Frontiers in Neurorobotics. Frontiers Research
Foundation. https://doi.org/10.3389/fnbot.2017.00008
chicago: Der, Ralf, and Georg S Martius. “Self Organized Behavior Generation for
Musculoskeletal Robots.” Frontiers in Neurorobotics. Frontiers Research
Foundation, 2017. https://doi.org/10.3389/fnbot.2017.00008.
ieee: R. Der and G. S. Martius, “Self organized behavior generation for musculoskeletal
robots,” Frontiers in Neurorobotics, vol. 11, no. MAR. Frontiers Research
Foundation, 2017.
ista: Der R, Martius GS. 2017. Self organized behavior generation for musculoskeletal
robots. Frontiers in Neurorobotics. 11(MAR), 00008.
mla: Der, Ralf, and Georg S. Martius. “Self Organized Behavior Generation for Musculoskeletal
Robots.” Frontiers in Neurorobotics, vol. 11, no. MAR, 00008, Frontiers
Research Foundation, 2017, doi:10.3389/fnbot.2017.00008.
short: R. Der, G.S. Martius, Frontiers in Neurorobotics 11 (2017).
date_created: 2018-12-11T11:47:45Z
date_published: 2017-03-16T00:00:00Z
date_updated: 2021-01-12T08:08:04Z
day: '16'
ddc:
- '006'
department:
- _id: ChLa
- _id: GaTk
doi: 10.3389/fnbot.2017.00008
ec_funded: 1
file:
- access_level: open_access
checksum: b1bc43f96d1df3313c03032c2a46388d
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:18:49Z
date_updated: 2020-07-14T12:47:33Z
file_id: '5371'
file_name: IST-2017-903-v1+1_fnbot-11-00008.pdf
file_size: 8439566
relation: main_file
file_date_updated: 2020-07-14T12:47:33Z
has_accepted_license: '1'
intvolume: ' 11'
issue: MAR
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Frontiers in Neurorobotics
publication_identifier:
issn:
- '16625218'
publication_status: published
publisher: Frontiers Research Foundation
publist_id: '7078'
pubrep_id: '903'
quality_controlled: '1'
scopus_import: 1
status: public
title: Self organized behavior generation for musculoskeletal robots
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2EBD1598-F248-11E8-B48F-1D18A9856A87
volume: 11
year: '2017'
...
---
_id: '659'
abstract:
- lang: eng
text: Migration frequently involves Rac-mediated protrusion of lamellipodia, formed
by Arp2/3 complex-dependent branching thought to be crucial for force generation
and stability of these networks. The formins FMNL2 and FMNL3 are Cdc42 effectors
targeting to the lamellipodium tip and shown here to nucleate and elongate actin
filaments with complementary activities in vitro. In migrating B16-F1 melanoma
cells, both formins contribute to the velocity of lamellipodium protrusion. Loss
of FMNL2/3 function in melanoma cells and fibroblasts reduces lamellipodial width,
actin filament density and -bundling, without changing patterns of Arp2/3 complex
incorporation. Strikingly, in melanoma cells, FMNL2/3 gene inactivation almost
completely abolishes protrusion forces exerted by lamellipodia and modifies their
ultrastructural organization. Consistently, CRISPR/Cas-mediated depletion of FMNL2/3
in fibroblasts reduces both migration and capability of cells to move against
viscous media. Together, we conclude that force generation in lamellipodia strongly
depends on FMNL formin activity, operating in addition to Arp2/3 complex-dependent
filament branching.
article_number: '14832'
article_processing_charge: No
author:
- first_name: Frieda
full_name: Kage, Frieda
last_name: Kage
- first_name: Moritz
full_name: Winterhoff, Moritz
last_name: Winterhoff
- first_name: Vanessa
full_name: Dimchev, Vanessa
last_name: Dimchev
- first_name: Jan
full_name: Müller, Jan
id: AD07FDB4-0F61-11EA-8158-C4CC64CEAA8D
last_name: Müller
- first_name: Tobias
full_name: Thalheim, Tobias
last_name: Thalheim
- first_name: Anika
full_name: Freise, Anika
last_name: Freise
- first_name: Stefan
full_name: Brühmann, Stefan
last_name: Brühmann
- first_name: Jana
full_name: Kollasser, Jana
last_name: Kollasser
- first_name: Jennifer
full_name: Block, Jennifer
last_name: Block
- first_name: Georgi A
full_name: Dimchev, Georgi A
last_name: Dimchev
- first_name: Matthias
full_name: Geyer, Matthias
last_name: Geyer
- first_name: Hams
full_name: Schnittler, Hams
last_name: Schnittler
- first_name: Cord
full_name: Brakebusch, Cord
last_name: Brakebusch
- first_name: Theresia
full_name: Stradal, Theresia
last_name: Stradal
- first_name: Marie
full_name: Carlier, Marie
last_name: Carlier
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Josef
full_name: Käs, Josef
last_name: Käs
- first_name: Jan
full_name: Faix, Jan
last_name: Faix
- first_name: Klemens
full_name: Rottner, Klemens
last_name: Rottner
citation:
ama: Kage F, Winterhoff M, Dimchev V, et al. FMNL formins boost lamellipodial force
generation. Nature Communications. 2017;8. doi:10.1038/ncomms14832
apa: Kage, F., Winterhoff, M., Dimchev, V., Müller, J., Thalheim, T., Freise, A.,
… Rottner, K. (2017). FMNL formins boost lamellipodial force generation. Nature
Communications. Nature Publishing Group. https://doi.org/10.1038/ncomms14832
chicago: Kage, Frieda, Moritz Winterhoff, Vanessa Dimchev, Jan Müller, Tobias Thalheim,
Anika Freise, Stefan Brühmann, et al. “FMNL Formins Boost Lamellipodial Force
Generation.” Nature Communications. Nature Publishing Group, 2017. https://doi.org/10.1038/ncomms14832.
ieee: F. Kage et al., “FMNL formins boost lamellipodial force generation,”
Nature Communications, vol. 8. Nature Publishing Group, 2017.
ista: Kage F, Winterhoff M, Dimchev V, Müller J, Thalheim T, Freise A, Brühmann
S, Kollasser J, Block J, Dimchev GA, Geyer M, Schnittler H, Brakebusch C, Stradal
T, Carlier M, Sixt MK, Käs J, Faix J, Rottner K. 2017. FMNL formins boost lamellipodial
force generation. Nature Communications. 8, 14832.
mla: Kage, Frieda, et al. “FMNL Formins Boost Lamellipodial Force Generation.” Nature
Communications, vol. 8, 14832, Nature Publishing Group, 2017, doi:10.1038/ncomms14832.
short: F. Kage, M. Winterhoff, V. Dimchev, J. Müller, T. Thalheim, A. Freise, S.
Brühmann, J. Kollasser, J. Block, G.A. Dimchev, M. Geyer, H. Schnittler, C. Brakebusch,
T. Stradal, M. Carlier, M.K. Sixt, J. Käs, J. Faix, K. Rottner, Nature Communications
8 (2017).
date_created: 2018-12-11T11:47:46Z
date_published: 2017-03-22T00:00:00Z
date_updated: 2021-01-12T08:08:06Z
day: '22'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.1038/ncomms14832
file:
- access_level: open_access
checksum: dae30190291c3630e8102d8714a8d23e
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:14:21Z
date_updated: 2020-07-14T12:47:34Z
file_id: '5072'
file_name: IST-2017-902-v1+1_Kage_et_al-2017-Nature_Communications.pdf
file_size: 9523746
relation: main_file
file_date_updated: 2020-07-14T12:47:34Z
has_accepted_license: '1'
intvolume: ' 8'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
publication: Nature Communications
publication_identifier:
issn:
- '20411723'
publication_status: published
publisher: Nature Publishing Group
publist_id: '7075'
pubrep_id: '902'
quality_controlled: '1'
scopus_import: 1
status: public
title: FMNL formins boost lamellipodial force generation
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2017'
...
---
_id: '660'
abstract:
- lang: eng
text: Growing microtubules are protected from depolymerization by the presence of
a GTP or GDP/Pi cap. End-binding proteins of the EB1 family bind to the stabilizing
cap, allowing monitoring of its size in real time. The cap size has been shown
to correlate with instantaneous microtubule stability. Here we have quantitatively
characterized the properties of cap size fluctuations during steadystate growth
and have developed a theory predicting their timescale and amplitude from the
kinetics of microtubule growth and cap maturation. In contrast to growth speed
fluctuations, cap size fluctuations show a characteristic timescale, which is
defined by the lifetime of the cap sites. Growth fluctuations affect the amplitude
of cap size fluctuations; however, cap size does not affect growth speed, indicating
that microtubules are far from instability during most of their time of growth.
Our theory provides the basis for a quantitative understanding of microtubule
stability fluctuations during steady-state growth.
acknowledgement: We thank Philippe Cluzel for helpful discussions and Gunnar Pruessner
for data analysis advice. This work was supported by the Francis Crick Institute,
which receives its core funding from Cancer Research UK Grant FC001163, Medical
Research Council Grant FC001163, and Wellcome Trust Grant FC001163. This work was
also supported by European Research Council Advanced Grant Project 323042 (to C.D.
and T.S.).
author:
- first_name: Jamie
full_name: Rickman, Jamie
last_name: Rickman
- first_name: Christian F
full_name: Düllberg, Christian F
id: 459064DC-F248-11E8-B48F-1D18A9856A87
last_name: Düllberg
orcid: 0000-0001-6335-9748
- first_name: Nicholas
full_name: Cade, Nicholas
last_name: Cade
- first_name: Lewis
full_name: Griffin, Lewis
last_name: Griffin
- first_name: Thomas
full_name: Surrey, Thomas
last_name: Surrey
citation:
ama: Rickman J, Düllberg CF, Cade N, Griffin L, Surrey T. Steady state EB cap size
fluctuations are determined by stochastic microtubule growth and maturation. PNAS.
2017;114(13):3427-3432. doi:10.1073/pnas.1620274114
apa: Rickman, J., Düllberg, C. F., Cade, N., Griffin, L., & Surrey, T. (2017).
Steady state EB cap size fluctuations are determined by stochastic microtubule
growth and maturation. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.1620274114
chicago: Rickman, Jamie, Christian F Düllberg, Nicholas Cade, Lewis Griffin, and
Thomas Surrey. “Steady State EB Cap Size Fluctuations Are Determined by Stochastic
Microtubule Growth and Maturation.” PNAS. National Academy of Sciences,
2017. https://doi.org/10.1073/pnas.1620274114.
ieee: J. Rickman, C. F. Düllberg, N. Cade, L. Griffin, and T. Surrey, “Steady state
EB cap size fluctuations are determined by stochastic microtubule growth and maturation,”
PNAS, vol. 114, no. 13. National Academy of Sciences, pp. 3427–3432, 2017.
ista: Rickman J, Düllberg CF, Cade N, Griffin L, Surrey T. 2017. Steady state EB
cap size fluctuations are determined by stochastic microtubule growth and maturation.
PNAS. 114(13), 3427–3432.
mla: Rickman, Jamie, et al. “Steady State EB Cap Size Fluctuations Are Determined
by Stochastic Microtubule Growth and Maturation.” PNAS, vol. 114, no. 13,
National Academy of Sciences, 2017, pp. 3427–32, doi:10.1073/pnas.1620274114.
short: J. Rickman, C.F. Düllberg, N. Cade, L. Griffin, T. Surrey, PNAS 114 (2017)
3427–3432.
date_created: 2018-12-11T11:47:46Z
date_published: 2017-03-28T00:00:00Z
date_updated: 2021-01-12T08:08:09Z
day: '28'
department:
- _id: MaLo
doi: 10.1073/pnas.1620274114
external_id:
pmid:
- '28280102'
intvolume: ' 114'
issue: '13'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5380103/
month: '03'
oa: 1
oa_version: Submitted Version
page: 3427 - 3432
pmid: 1
publication: PNAS
publication_identifier:
issn:
- '00278424'
publication_status: published
publisher: National Academy of Sciences
publist_id: '7073'
quality_controlled: '1'
scopus_import: 1
status: public
title: Steady state EB cap size fluctuations are determined by stochastic microtubule
growth and maturation
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 114
year: '2017'
...
---
_id: '662'
abstract:
- lang: eng
text: 'We report a direct-numerical-simulation study of the Taylor-Couette flow
in the quasi-Keplerian regime at shear Reynolds numbers up to (105). Quasi-Keplerian
rotating flow has been investigated for decades as a simplified model system to
study the origin of turbulence in accretion disks that is not fully understood.
The flow in this study is axially periodic and thus the experimental end-wall
effects on the stability of the flow are avoided. Using optimal linear perturbations
as initial conditions, our simulations find no sustained turbulence: the strong
initial perturbations distort the velocity profile and trigger turbulence that
eventually decays.'
article_number: '044107'
author:
- first_name: Liang
full_name: Shi, Liang
last_name: Shi
- first_name: Björn
full_name: Hof, Björn
id: 3A374330-F248-11E8-B48F-1D18A9856A87
last_name: Hof
orcid: 0000-0003-2057-2754
- first_name: Markus
full_name: Rampp, Markus
last_name: Rampp
- first_name: Marc
full_name: Avila, Marc
last_name: Avila
citation:
ama: Shi L, Hof B, Rampp M, Avila M. Hydrodynamic turbulence in quasi Keplerian
rotating flows. Physics of Fluids. 2017;29(4). doi:10.1063/1.4981525
apa: Shi, L., Hof, B., Rampp, M., & Avila, M. (2017). Hydrodynamic turbulence
in quasi Keplerian rotating flows. Physics of Fluids. American Institute
of Physics. https://doi.org/10.1063/1.4981525
chicago: Shi, Liang, Björn Hof, Markus Rampp, and Marc Avila. “Hydrodynamic Turbulence
in Quasi Keplerian Rotating Flows.” Physics of Fluids. American Institute
of Physics, 2017. https://doi.org/10.1063/1.4981525.
ieee: L. Shi, B. Hof, M. Rampp, and M. Avila, “Hydrodynamic turbulence in quasi
Keplerian rotating flows,” Physics of Fluids, vol. 29, no. 4. American
Institute of Physics, 2017.
ista: Shi L, Hof B, Rampp M, Avila M. 2017. Hydrodynamic turbulence in quasi Keplerian
rotating flows. Physics of Fluids. 29(4), 044107.
mla: Shi, Liang, et al. “Hydrodynamic Turbulence in Quasi Keplerian Rotating Flows.”
Physics of Fluids, vol. 29, no. 4, 044107, American Institute of Physics,
2017, doi:10.1063/1.4981525.
short: L. Shi, B. Hof, M. Rampp, M. Avila, Physics of Fluids 29 (2017).
date_created: 2018-12-11T11:47:47Z
date_published: 2017-04-01T00:00:00Z
date_updated: 2021-01-12T08:08:15Z
day: '01'
department:
- _id: BjHo
doi: 10.1063/1.4981525
intvolume: ' 29'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1703.01714
month: '04'
oa: 1
oa_version: Submitted Version
project:
- _id: 2511D90C-B435-11E9-9278-68D0E5697425
grant_number: SFB 963 TP A8
name: Astrophysical instability of currents and turbulences
publication: Physics of Fluids
publication_identifier:
issn:
- '10706631'
publication_status: published
publisher: American Institute of Physics
publist_id: '7072'
quality_controlled: '1'
scopus_import: 1
status: public
title: Hydrodynamic turbulence in quasi Keplerian rotating flows
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 29
year: '2017'
...
---
_id: '663'
abstract:
- lang: eng
text: 'In this paper, we propose an approach to automatically compute invariant
clusters for nonlinear semialgebraic hybrid systems. An invariant cluster for
an ordinary differential equation (ODE) is a multivariate polynomial invariant
g(u→, x→) = 0, parametric in u→, which can yield an infinite number of concrete
invariants by assigning different values to u→ so that every trajectory of the
system can be overapproximated precisely by the intersection of a group of concrete
invariants. For semialgebraic systems, which involve ODEs with multivariate polynomial
right-hand sides, given a template multivariate polynomial g(u→, x→), an invariant
cluster can be obtained by first computing the remainder of the Lie derivative
of g(u→, x→) divided by g(u→, x→) and then solving the system of polynomial equations
obtained from the coefficients of the remainder. Based on invariant clusters and
sum-of-squares (SOS) programming, we present a new method for the safety verification
of hybrid systems. Experiments on nonlinear benchmark systems from biology and
control theory show that our approach is efficient. '
author:
- first_name: Hui
full_name: Kong, Hui
id: 3BDE25AA-F248-11E8-B48F-1D18A9856A87
last_name: Kong
orcid: 0000-0002-3066-6941
- first_name: Sergiy
full_name: Bogomolov, Sergiy
last_name: Bogomolov
orcid: 0000-0002-0686-0365
- first_name: Christian
full_name: Schilling, Christian
last_name: Schilling
- first_name: Yu
full_name: Jiang, Yu
last_name: Jiang
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
citation:
ama: 'Kong H, Bogomolov S, Schilling C, Jiang Y, Henzinger TA. Safety verification
of nonlinear hybrid systems based on invariant clusters. In: Proceedings of
the 20th International Conference on Hybrid Systems. ACM; 2017:163-172. doi:10.1145/3049797.3049814'
apa: 'Kong, H., Bogomolov, S., Schilling, C., Jiang, Y., & Henzinger, T. A.
(2017). Safety verification of nonlinear hybrid systems based on invariant clusters.
In Proceedings of the 20th International Conference on Hybrid Systems (pp.
163–172). Pittsburgh, PA, United States: ACM. https://doi.org/10.1145/3049797.3049814'
chicago: Kong, Hui, Sergiy Bogomolov, Christian Schilling, Yu Jiang, and Thomas
A Henzinger. “Safety Verification of Nonlinear Hybrid Systems Based on Invariant
Clusters.” In Proceedings of the 20th International Conference on Hybrid Systems,
163–72. ACM, 2017. https://doi.org/10.1145/3049797.3049814.
ieee: H. Kong, S. Bogomolov, C. Schilling, Y. Jiang, and T. A. Henzinger, “Safety
verification of nonlinear hybrid systems based on invariant clusters,” in Proceedings
of the 20th International Conference on Hybrid Systems, Pittsburgh, PA, United
States, 2017, pp. 163–172.
ista: 'Kong H, Bogomolov S, Schilling C, Jiang Y, Henzinger TA. 2017. Safety verification
of nonlinear hybrid systems based on invariant clusters. Proceedings of the 20th
International Conference on Hybrid Systems. HSCC: Hybrid Systems Computation and
Control , 163–172.'
mla: Kong, Hui, et al. “Safety Verification of Nonlinear Hybrid Systems Based on
Invariant Clusters.” Proceedings of the 20th International Conference on Hybrid
Systems, ACM, 2017, pp. 163–72, doi:10.1145/3049797.3049814.
short: H. Kong, S. Bogomolov, C. Schilling, Y. Jiang, T.A. Henzinger, in:, Proceedings
of the 20th International Conference on Hybrid Systems, ACM, 2017, pp. 163–172.
conference:
end_date: 2017-04-20
location: Pittsburgh, PA, United States
name: 'HSCC: Hybrid Systems Computation and Control '
start_date: 2017-04-18
date_created: 2018-12-11T11:47:47Z
date_published: 2017-04-01T00:00:00Z
date_updated: 2021-01-12T08:08:17Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1145/3049797.3049814
file:
- access_level: open_access
checksum: b7667434cbf5b5f0ade3bea1dbe5bf63
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:11:20Z
date_updated: 2020-07-14T12:47:34Z
file_id: '4873'
file_name: IST-2017-817-v1+1_p163-kong.pdf
file_size: 1650530
relation: main_file
file_date_updated: 2020-07-14T12:47:34Z
has_accepted_license: '1'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Submitted Version
page: 163 - 172
publication: Proceedings of the 20th International Conference on Hybrid Systems
publication_identifier:
isbn:
- 978-145034590-3
publication_status: published
publisher: ACM
publist_id: '7067'
pubrep_id: '817'
quality_controlled: '1'
scopus_import: 1
status: public
title: Safety verification of nonlinear hybrid systems based on invariant clusters
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2017'
...
---
_id: '667'
abstract:
- lang: eng
text: Perinatal exposure to penicillin may result in longlasting gut and behavioral
changes.
article_number: '2786'
author:
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
citation:
ama: Novarino G. The antisocial side of antibiotics. Science Translational Medicine.
2017;9(387). doi:10.1126/scitranslmed.aan2786
apa: Novarino, G. (2017). The antisocial side of antibiotics. Science Translational
Medicine. American Association for the Advancement of Science. https://doi.org/10.1126/scitranslmed.aan2786
chicago: Novarino, Gaia. “The Antisocial Side of Antibiotics.” Science Translational
Medicine. American Association for the Advancement of Science, 2017. https://doi.org/10.1126/scitranslmed.aan2786.
ieee: G. Novarino, “The antisocial side of antibiotics,” Science Translational
Medicine, vol. 9, no. 387. American Association for the Advancement of Science,
2017.
ista: Novarino G. 2017. The antisocial side of antibiotics. Science Translational
Medicine. 9(387), 2786.
mla: Novarino, Gaia. “The Antisocial Side of Antibiotics.” Science Translational
Medicine, vol. 9, no. 387, 2786, American Association for the Advancement
of Science, 2017, doi:10.1126/scitranslmed.aan2786.
short: G. Novarino, Science Translational Medicine 9 (2017).
date_created: 2018-12-11T11:47:48Z
date_published: 2017-04-26T00:00:00Z
date_updated: 2021-01-12T08:08:30Z
day: '26'
department:
- _id: GaNo
doi: 10.1126/scitranslmed.aan2786
intvolume: ' 9'
issue: '387'
language:
- iso: eng
month: '04'
oa_version: None
publication: Science Translational Medicine
publication_identifier:
issn:
- '19466234'
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '7060'
quality_controlled: '1'
scopus_import: 1
status: public
title: The antisocial side of antibiotics
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2017'
...
---
_id: '668'
abstract:
- lang: eng
text: Macrophage filopodia, finger-like membrane protrusions, were first implicated
in phagocytosis more than 100 years ago, but little is still known about the involvement
of these actin-dependent structures in particle clearance. Using spinning disk
confocal microscopy to image filopodial dynamics in mouse resident Lifeact-EGFP
macrophages, we show that filopodia, or filopodia-like structures, support pathogen
clearance by multiple means. Filopodia supported the phagocytic uptake of bacterial
(Escherichia coli) particles by (i) capturing along the filopodial shaft and surfing
toward the cell body, the most common mode of capture; (ii) capturing via the
tip followed by retraction; (iii) combinations of surfing and retraction; or (iv)
sweeping actions. In addition, filopodia supported the uptake of zymosan (Saccharomyces
cerevisiae) particles by (i) providing fixation, (ii) capturing at the tip and
filopodia-guided actin anterograde flow with phagocytic cup formation, and (iii)
the rapid growth of new protrusions. To explore the role of filopodia-inducing
Cdc42, we generated myeloid-restricted Cdc42 knock-out mice. Cdc42-deficient macrophages
exhibited rapid phagocytic cup kinetics, but reduced particle clearance, which
could be explained by the marked rounded-up morphology of these cells. Macrophages
lacking Myo10, thought to act downstream of Cdc42, had normal morphology, motility,
and phagocytic cup formation, but displayed markedly reduced filopodia formation.
In conclusion, live-cell imaging revealed multiple mechanisms involving macrophage
filopodia in particle capture and engulfment. Cdc42 is not critical for filopodia
or phagocytic cup formation, but plays a key role in driving macrophage lamellipodial
spreading.
article_type: original
author:
- first_name: Markus
full_name: Horsthemke, Markus
last_name: Horsthemke
- first_name: Anne
full_name: Bachg, Anne
last_name: Bachg
- first_name: Katharina
full_name: Groll, Katharina
last_name: Groll
- first_name: Sven
full_name: Moyzio, Sven
last_name: Moyzio
- first_name: Barbara
full_name: Müther, Barbara
last_name: Müther
- first_name: Sandra
full_name: Hemkemeyer, Sandra
last_name: Hemkemeyer
- first_name: Roland
full_name: Wedlich Söldner, Roland
last_name: Wedlich Söldner
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Sebastian
full_name: Tacke, Sebastian
last_name: Tacke
- first_name: Martin
full_name: Bähler, Martin
last_name: Bähler
- first_name: Peter
full_name: Hanley, Peter
last_name: Hanley
citation:
ama: Horsthemke M, Bachg A, Groll K, et al. Multiple roles of filopodial dynamics
in particle capture and phagocytosis and phenotypes of Cdc42 and Myo10 deletion.
Journal of Biological Chemistry. 2017;292(17):7258-7273. doi:10.1074/jbc.M116.766923
apa: Horsthemke, M., Bachg, A., Groll, K., Moyzio, S., Müther, B., Hemkemeyer, S.,
… Hanley, P. (2017). Multiple roles of filopodial dynamics in particle capture
and phagocytosis and phenotypes of Cdc42 and Myo10 deletion. Journal of Biological
Chemistry. American Society for Biochemistry and Molecular Biology. https://doi.org/10.1074/jbc.M116.766923
chicago: Horsthemke, Markus, Anne Bachg, Katharina Groll, Sven Moyzio, Barbara Müther,
Sandra Hemkemeyer, Roland Wedlich Söldner, et al. “Multiple Roles of Filopodial
Dynamics in Particle Capture and Phagocytosis and Phenotypes of Cdc42 and Myo10
Deletion.” Journal of Biological Chemistry. American Society for Biochemistry
and Molecular Biology, 2017. https://doi.org/10.1074/jbc.M116.766923.
ieee: M. Horsthemke et al., “Multiple roles of filopodial dynamics in particle
capture and phagocytosis and phenotypes of Cdc42 and Myo10 deletion,” Journal
of Biological Chemistry, vol. 292, no. 17. American Society for Biochemistry
and Molecular Biology, pp. 7258–7273, 2017.
ista: Horsthemke M, Bachg A, Groll K, Moyzio S, Müther B, Hemkemeyer S, Wedlich
Söldner R, Sixt MK, Tacke S, Bähler M, Hanley P. 2017. Multiple roles of filopodial
dynamics in particle capture and phagocytosis and phenotypes of Cdc42 and Myo10
deletion. Journal of Biological Chemistry. 292(17), 7258–7273.
mla: Horsthemke, Markus, et al. “Multiple Roles of Filopodial Dynamics in Particle
Capture and Phagocytosis and Phenotypes of Cdc42 and Myo10 Deletion.” Journal
of Biological Chemistry, vol. 292, no. 17, American Society for Biochemistry
and Molecular Biology, 2017, pp. 7258–73, doi:10.1074/jbc.M116.766923.
short: M. Horsthemke, A. Bachg, K. Groll, S. Moyzio, B. Müther, S. Hemkemeyer, R.
Wedlich Söldner, M.K. Sixt, S. Tacke, M. Bähler, P. Hanley, Journal of Biological
Chemistry 292 (2017) 7258–7273.
date_created: 2018-12-11T11:47:49Z
date_published: 2017-04-28T00:00:00Z
date_updated: 2021-01-12T08:08:34Z
day: '28'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.1074/jbc.M116.766923
file:
- access_level: open_access
checksum: d488162874326a4bb056065fa549dc4a
content_type: application/pdf
creator: dernst
date_created: 2019-10-24T15:25:42Z
date_updated: 2020-07-14T12:47:37Z
file_id: '6971'
file_name: 2017_JBC_Horsthemke.pdf
file_size: 5647880
relation: main_file
file_date_updated: 2020-07-14T12:47:37Z
has_accepted_license: '1'
intvolume: ' 292'
issue: '17'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 7258 - 7273
publication: Journal of Biological Chemistry
publication_identifier:
issn:
- '00219258'
publication_status: published
publisher: American Society for Biochemistry and Molecular Biology
publist_id: '7059'
quality_controlled: '1'
scopus_import: 1
status: public
title: Multiple roles of filopodial dynamics in particle capture and phagocytosis
and phenotypes of Cdc42 and Myo10 deletion
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 292
year: '2017'
...
---
_id: '669'
abstract:
- lang: eng
text: 'The exocyst, a eukaryotic tethering complex, coregulates targeted exocytosis
as an effector of small GTPases in polarized cell growth. In land plants, several
exocyst subunits are encoded by double or triple paralogs, culminating in tens
of EXO70 paralogs. Out of 23 Arabidopsis thaliana EXO70 isoforms, we analyzed
seven isoforms expressed in pollen. Genetic and microscopic analyses of single
mutants in EXO70A2, EXO70C1, EXO70C2, EXO70F1, EXO70H3, EXO70H5, and EXO70H6 genes
revealed that only a loss-of-function EXO70C2 allele resulted in a significant
male-specific transmission defect (segregation 40%:51%:9%) due to aberrant pollen
tube growth. Mutant pollen tubes grown in vitro exhibited an enhanced growth rate
and a decreased thickness of the tip cell wall, causing tip bursts. However, exo70C2
pollen tubes could frequently recover and restart their speedy elongation, resulting
in a repetitive stop-and-go growth dynamics. A pollenspecific depletion of the
closest paralog, EXO70C1, using artificial microRNA in the exo70C2 mutant background,
resulted in a complete pollen-specific transmission defect, suggesting redundant
functions of EXO70C1 and EXO70C2. Both EXO70C1 and EXO70C2, GFP tagged and expressed
under the control of their native promoters, localized in the cytoplasm of pollen
grains, pollen tubes, and also root trichoblast cells. The expression of EXO70C2-GFP
complemented the aberrant growth of exo70C2 pollen tubes. The absent EXO70C2 interactions
with core exocyst subunits in the yeast two-hybrid assay, cytoplasmic localization,
and genetic effect suggest an unconventional EXO70 function possibly as a regulator
of exocytosis outside the exocyst complex. In conclusion, EXO70C2 is a novel factor
contributing to the regulation of optimal tip growth of Arabidopsis pollen tubes. '
article_processing_charge: No
article_type: original
author:
- first_name: Lukáš
full_name: Synek, Lukáš
last_name: Synek
- first_name: Nemanja
full_name: Vukašinović, Nemanja
last_name: Vukašinović
- first_name: Ivan
full_name: Kulich, Ivan
last_name: Kulich
- first_name: Michal
full_name: Hála, Michal
last_name: Hála
- first_name: Klára
full_name: Aldorfová, Klára
last_name: Aldorfová
- first_name: Matyas
full_name: Fendrych, Matyas
id: 43905548-F248-11E8-B48F-1D18A9856A87
last_name: Fendrych
orcid: 0000-0002-9767-8699
- first_name: Viktor
full_name: Žárský, Viktor
last_name: Žárský
citation:
ama: Synek L, Vukašinović N, Kulich I, et al. EXO70C2 is a key regulatory factor
for optimal tip growth of pollen. Plant Physiology. 2017;174(1):223-240.
doi:10.1104/pp.16.01282
apa: Synek, L., Vukašinović, N., Kulich, I., Hála, M., Aldorfová, K., Fendrych,
M., & Žárský, V. (2017). EXO70C2 is a key regulatory factor for optimal tip
growth of pollen. Plant Physiology. American Society of Plant Biologists.
https://doi.org/10.1104/pp.16.01282
chicago: Synek, Lukáš, Nemanja Vukašinović, Ivan Kulich, Michal Hála, Klára Aldorfová,
Matyas Fendrych, and Viktor Žárský. “EXO70C2 Is a Key Regulatory Factor for Optimal
Tip Growth of Pollen.” Plant Physiology. American Society of Plant Biologists,
2017. https://doi.org/10.1104/pp.16.01282.
ieee: L. Synek et al., “EXO70C2 is a key regulatory factor for optimal tip
growth of pollen,” Plant Physiology, vol. 174, no. 1. American Society
of Plant Biologists, pp. 223–240, 2017.
ista: Synek L, Vukašinović N, Kulich I, Hála M, Aldorfová K, Fendrych M, Žárský
V. 2017. EXO70C2 is a key regulatory factor for optimal tip growth of pollen.
Plant Physiology. 174(1), 223–240.
mla: Synek, Lukáš, et al. “EXO70C2 Is a Key Regulatory Factor for Optimal Tip Growth
of Pollen.” Plant Physiology, vol. 174, no. 1, American Society of Plant
Biologists, 2017, pp. 223–40, doi:10.1104/pp.16.01282.
short: L. Synek, N. Vukašinović, I. Kulich, M. Hála, K. Aldorfová, M. Fendrych,
V. Žárský, Plant Physiology 174 (2017) 223–240.
date_created: 2018-12-11T11:47:49Z
date_published: 2017-05-01T00:00:00Z
date_updated: 2021-01-12T08:08:35Z
day: '01'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1104/pp.16.01282
external_id:
pmid:
- '28356503'
file:
- access_level: open_access
checksum: 97155acc6aa5f0d0a78e0589a932fe02
content_type: application/pdf
creator: dernst
date_created: 2019-11-18T16:16:18Z
date_updated: 2020-07-14T12:47:37Z
file_id: '7041'
file_name: 2017_PlantPhysio_Synek.pdf
file_size: 2176903
relation: main_file
file_date_updated: 2020-07-14T12:47:37Z
has_accepted_license: '1'
intvolume: ' 174'
issue: '1'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
page: 223 - 240
pmid: 1
publication: Plant Physiology
publication_identifier:
issn:
- '00320889'
publication_status: published
publisher: American Society of Plant Biologists
publist_id: '7058'
quality_controlled: '1'
scopus_import: 1
status: public
title: EXO70C2 is a key regulatory factor for optimal tip growth of pollen
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 174
year: '2017'
...
---
_id: '671'
abstract:
- lang: eng
text: Humans routinely use conditionally cooperative strategies when interacting
in repeated social dilemmas. They are more likely to cooperate if others cooperated
before, and are ready to retaliate if others defected. To capture the emergence
of reciprocity, most previous models consider subjects who can only choose from
a restricted set of representative strategies, or who react to the outcome of
the very last round only. As players memorize more rounds, the dimension of the
strategy space increases exponentially. This increasing computational complexity
renders simulations for individuals with higher cognitive abilities infeasible,
especially if multiplayer interactions are taken into account. Here, we take an
axiomatic approach instead. We propose several properties that a robust cooperative
strategy for a repeated multiplayer dilemma should have. These properties naturally
lead to a unique class of cooperative strategies, which contains the classical
Win-Stay Lose-Shift rule as a special case. A comprehensive numerical analysis
for the prisoner's dilemma and for the public goods game suggests that strategies
of this class readily evolve across various memory-n spaces. Our results reveal
that successful strategies depend not only on how cooperative others were in the
past but also on the respective context of cooperation.
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Christian
full_name: Hilbe, Christian
id: 2FDF8F3C-F248-11E8-B48F-1D18A9856A87
last_name: Hilbe
orcid: 0000-0001-5116-955X
- first_name: Vaquero
full_name: Martinez, Vaquero
last_name: Martinez
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
citation:
ama: Hilbe C, Martinez V, Chatterjee K, Nowak M. Memory-n strategies of direct reciprocity.
PNAS. 2017;114(18):4715-4720. doi:10.1073/pnas.1621239114
apa: Hilbe, C., Martinez, V., Chatterjee, K., & Nowak, M. (2017). Memory-n strategies
of direct reciprocity. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.1621239114
chicago: Hilbe, Christian, Vaquero Martinez, Krishnendu Chatterjee, and Martin Nowak.
“Memory-n Strategies of Direct Reciprocity.” PNAS. National Academy of
Sciences, 2017. https://doi.org/10.1073/pnas.1621239114.
ieee: C. Hilbe, V. Martinez, K. Chatterjee, and M. Nowak, “Memory-n strategies of
direct reciprocity,” PNAS, vol. 114, no. 18. National Academy of Sciences,
pp. 4715–4720, 2017.
ista: Hilbe C, Martinez V, Chatterjee K, Nowak M. 2017. Memory-n strategies of direct
reciprocity. PNAS. 114(18), 4715–4720.
mla: Hilbe, Christian, et al. “Memory-n Strategies of Direct Reciprocity.” PNAS,
vol. 114, no. 18, National Academy of Sciences, 2017, pp. 4715–20, doi:10.1073/pnas.1621239114.
short: C. Hilbe, V. Martinez, K. Chatterjee, M. Nowak, PNAS 114 (2017) 4715–4720.
date_created: 2018-12-11T11:47:50Z
date_published: 2017-05-02T00:00:00Z
date_updated: 2021-01-12T08:08:37Z
day: '02'
department:
- _id: KrCh
doi: 10.1073/pnas.1621239114
ec_funded: 1
external_id:
pmid:
- '28420786'
intvolume: ' 114'
issue: '18'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5422766/
month: '05'
oa: 1
oa_version: Published Version
page: 4715 - 4720
pmid: 1
project:
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
publication: PNAS
publication_identifier:
issn:
- '00278424'
publication_status: published
publisher: National Academy of Sciences
publist_id: '7053'
quality_controlled: '1'
scopus_import: 1
status: public
title: Memory-n strategies of direct reciprocity
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 114
year: '2017'
...
---
_id: '670'
abstract:
- lang: eng
text: We propose an efficient method to model paper tearing in the context of interactive
modeling. The method uses geometrical information to automatically detect potential
starting points of tears. We further introduce a new hybrid geometrical and physical-based
method to compute the trajectory of tears while procedurally synthesizing high
resolution details of the tearing path using a texture based approach. The results
obtained are compared with real paper and with previous studies on the expected
geometric paths of paper that tears.
article_processing_charge: No
article_type: original
author:
- first_name: Camille
full_name: Schreck, Camille
id: 2B14B676-F248-11E8-B48F-1D18A9856A87
last_name: Schreck
- first_name: Damien
full_name: Rohmer, Damien
last_name: Rohmer
- first_name: Stefanie
full_name: Hahmann, Stefanie
last_name: Hahmann
citation:
ama: Schreck C, Rohmer D, Hahmann S. Interactive paper tearing. Computer Graphics
Forum. 2017;36(2):95-106. doi:10.1111/cgf.13110
apa: Schreck, C., Rohmer, D., & Hahmann, S. (2017). Interactive paper tearing.
Computer Graphics Forum. Wiley. https://doi.org/10.1111/cgf.13110
chicago: Schreck, Camille, Damien Rohmer, and Stefanie Hahmann. “Interactive Paper
Tearing.” Computer Graphics Forum. Wiley, 2017. https://doi.org/10.1111/cgf.13110.
ieee: C. Schreck, D. Rohmer, and S. Hahmann, “Interactive paper tearing,” Computer
Graphics Forum, vol. 36, no. 2. Wiley, pp. 95–106, 2017.
ista: Schreck C, Rohmer D, Hahmann S. 2017. Interactive paper tearing. Computer
Graphics Forum. 36(2), 95–106.
mla: Schreck, Camille, et al. “Interactive Paper Tearing.” Computer Graphics
Forum, vol. 36, no. 2, Wiley, 2017, pp. 95–106, doi:10.1111/cgf.13110.
short: C. Schreck, D. Rohmer, S. Hahmann, Computer Graphics Forum 36 (2017) 95–106.
date_created: 2018-12-11T11:47:49Z
date_published: 2017-05-01T00:00:00Z
date_updated: 2021-01-12T08:08:37Z
day: '01'
ddc:
- '000'
department:
- _id: ChWo
doi: 10.1111/cgf.13110
intvolume: ' 36'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://hal.inria.fr/hal-01647113/file/eg_2017_schreck_paper_tearing.pdf
month: '05'
oa: 1
oa_version: Published Version
page: 95 - 106
project:
- _id: 25357BD2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 24352-N23
name: 'Deep Pictures: Creating Visual and Haptic Vector Images'
publication: Computer Graphics Forum
publication_identifier:
issn:
- '01677055'
publication_status: published
publisher: Wiley
publist_id: '7056'
quality_controlled: '1'
scopus_import: 1
status: public
title: Interactive paper tearing
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2017'
...
---
_id: '672'
abstract:
- lang: eng
text: Trafficking cells frequently transmigrate through epithelial and endothelial
monolayers. How monolayers cooperate with the penetrating cells to support their
transit is poorly understood. We studied dendritic cell (DC) entry into lymphatic
capillaries as a model system for transendothelial migration. We find that the
chemokine CCL21, which is the decisive guidance cue for intravasation, mainly
localizes in the trans-Golgi network and intracellular vesicles of lymphatic endothelial
cells. Upon DC transmigration, these Golgi deposits disperse and CCL21 becomes
extracellularly enriched at the sites of endothelial cell-cell junctions. When
we reconstitute the transmigration process in vitro, we find that secretion of
CCL21-positive vesicles is triggered by a DC contact-induced calcium signal, and
selective calcium chelation in lymphatic endothelium attenuates transmigration.
Altogether, our data demonstrate a chemokine-mediated feedback between DCs and
lymphatic endothelium, which facilitates transendothelial migration.
article_processing_charge: Yes
author:
- first_name: Kari
full_name: Vaahtomeri, Kari
id: 368EE576-F248-11E8-B48F-1D18A9856A87
last_name: Vaahtomeri
orcid: 0000-0001-7829-3518
- first_name: Markus
full_name: Brown, Markus
id: 3DAB9AFC-F248-11E8-B48F-1D18A9856A87
last_name: Brown
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Ingrid
full_name: De Vries, Ingrid
id: 4C7D837E-F248-11E8-B48F-1D18A9856A87
last_name: De Vries
- first_name: Alexander F
full_name: Leithner, Alexander F
id: 3B1B77E4-F248-11E8-B48F-1D18A9856A87
last_name: Leithner
- first_name: Matthias
full_name: Mehling, Matthias
id: 3C23B994-F248-11E8-B48F-1D18A9856A87
last_name: Mehling
orcid: 0000-0001-8599-1226
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Vaahtomeri K, Brown M, Hauschild R, et al. Locally triggered release of the
chemokine CCL21 promotes dendritic cell transmigration across lymphatic endothelia.
Cell Reports. 2017;19(5):902-909. doi:10.1016/j.celrep.2017.04.027
apa: Vaahtomeri, K., Brown, M., Hauschild, R., de Vries, I., Leithner, A. F., Mehling,
M., … Sixt, M. K. (2017). Locally triggered release of the chemokine CCL21 promotes
dendritic cell transmigration across lymphatic endothelia. Cell Reports.
Cell Press. https://doi.org/10.1016/j.celrep.2017.04.027
chicago: Vaahtomeri, Kari, Markus Brown, Robert Hauschild, Ingrid de Vries, Alexander
F Leithner, Matthias Mehling, Walter Kaufmann, and Michael K Sixt. “Locally Triggered
Release of the Chemokine CCL21 Promotes Dendritic Cell Transmigration across Lymphatic
Endothelia.” Cell Reports. Cell Press, 2017. https://doi.org/10.1016/j.celrep.2017.04.027.
ieee: K. Vaahtomeri et al., “Locally triggered release of the chemokine CCL21
promotes dendritic cell transmigration across lymphatic endothelia,” Cell Reports,
vol. 19, no. 5. Cell Press, pp. 902–909, 2017.
ista: Vaahtomeri K, Brown M, Hauschild R, de Vries I, Leithner AF, Mehling M, Kaufmann
W, Sixt MK. 2017. Locally triggered release of the chemokine CCL21 promotes dendritic
cell transmigration across lymphatic endothelia. Cell Reports. 19(5), 902–909.
mla: Vaahtomeri, Kari, et al. “Locally Triggered Release of the Chemokine CCL21
Promotes Dendritic Cell Transmigration across Lymphatic Endothelia.” Cell Reports,
vol. 19, no. 5, Cell Press, 2017, pp. 902–09, doi:10.1016/j.celrep.2017.04.027.
short: K. Vaahtomeri, M. Brown, R. Hauschild, I. de Vries, A.F. Leithner, M. Mehling,
W. Kaufmann, M.K. Sixt, Cell Reports 19 (2017) 902–909.
date_created: 2018-12-11T11:47:50Z
date_published: 2017-05-02T00:00:00Z
date_updated: 2023-02-23T12:50:09Z
day: '02'
ddc:
- '570'
department:
- _id: MiSi
- _id: Bio
- _id: EM-Fac
doi: 10.1016/j.celrep.2017.04.027
ec_funded: 1
file:
- access_level: open_access
checksum: 8fdddaab1f1d76a6ec9ca94dcb6b07a2
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:14:54Z
date_updated: 2020-07-14T12:47:38Z
file_id: '5109'
file_name: IST-2017-900-v1+1_1-s2.0-S2211124717305211-main.pdf
file_size: 2248814
relation: main_file
file_date_updated: 2020-07-14T12:47:38Z
has_accepted_license: '1'
intvolume: ' 19'
issue: '5'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 902 - 909
project:
- _id: 25A603A2-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '281556'
name: Cytoskeletal force generation and force transduction of migrating leukocytes
(EU)
- _id: 25A8E5EA-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Y 564-B12
name: Cytoskeletal force generation and transduction of leukocytes (FWF)
publication: Cell Reports
publication_identifier:
issn:
- '22111247'
publication_status: published
publisher: Cell Press
publist_id: '7052'
pubrep_id: '900'
quality_controlled: '1'
scopus_import: 1
status: public
title: Locally triggered release of the chemokine CCL21 promotes dendritic cell transmigration
across lymphatic endothelia
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2017'
...
---
_id: '674'
abstract:
- lang: eng
text: Navigation of cells along gradients of guidance cues is a determining step
in many developmental and immunological processes. Gradients can either be soluble
or immobilized to tissues as demonstrated for the haptotactic migration of dendritic
cells (DCs) toward higher concentrations of immobilized chemokine CCL21. To elucidate
how gradient characteristics govern cellular response patterns, we here introduce
an in vitro system allowing to track migratory responses of DCs to precisely controlled
immobilized gradients of CCL21. We find that haptotactic sensing depends on the
absolute CCL21 concentration and local steepness of the gradient, consistent with
a scenario where DC directionality is governed by the signal-to-noise ratio of
CCL21 binding to the receptor CCR7. We find that the conditions for optimal DC
guidance are perfectly provided by the CCL21 gradients we measure in vivo. Furthermore,
we find that CCR7 signal termination by the G-protein-coupled receptor kinase
6 (GRK6) is crucial for haptotactic but dispensable for chemotactic CCL21 gradient
sensing in vitro and confirm those observations in vivo. These findings suggest
that stable, tissue-bound CCL21 gradients as sustainable “roads” ensure optimal
guidance in vivo.
author:
- first_name: Jan
full_name: Schwarz, Jan
id: 346C1EC6-F248-11E8-B48F-1D18A9856A87
last_name: Schwarz
- first_name: Veronika
full_name: Bierbaum, Veronika
id: 3FD04378-F248-11E8-B48F-1D18A9856A87
last_name: Bierbaum
- first_name: Kari
full_name: Vaahtomeri, Kari
id: 368EE576-F248-11E8-B48F-1D18A9856A87
last_name: Vaahtomeri
orcid: 0000-0001-7829-3518
- first_name: Robert
full_name: Hauschild, Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
orcid: 0000-0001-9843-3522
- first_name: Markus
full_name: Brown, Markus
id: 3DAB9AFC-F248-11E8-B48F-1D18A9856A87
last_name: Brown
- first_name: Ingrid
full_name: De Vries, Ingrid
id: 4C7D837E-F248-11E8-B48F-1D18A9856A87
last_name: De Vries
- first_name: Alexander F
full_name: Leithner, Alexander F
id: 3B1B77E4-F248-11E8-B48F-1D18A9856A87
last_name: Leithner
- first_name: Anne
full_name: Reversat, Anne
id: 35B76592-F248-11E8-B48F-1D18A9856A87
last_name: Reversat
orcid: 0000-0003-0666-8928
- first_name: Jack
full_name: Merrin, Jack
id: 4515C308-F248-11E8-B48F-1D18A9856A87
last_name: Merrin
orcid: 0000-0001-5145-4609
- first_name: Teresa
full_name: Tarrant, Teresa
last_name: Tarrant
- first_name: Tobias
full_name: Bollenbach, Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
orcid: 0000-0003-4398-476X
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Schwarz J, Bierbaum V, Vaahtomeri K, et al. Dendritic cells interpret haptotactic
chemokine gradients in a manner governed by signal to noise ratio and dependent
on GRK6. Current Biology. 2017;27(9):1314-1325. doi:10.1016/j.cub.2017.04.004
apa: Schwarz, J., Bierbaum, V., Vaahtomeri, K., Hauschild, R., Brown, M., de Vries,
I., … Sixt, M. K. (2017). Dendritic cells interpret haptotactic chemokine gradients
in a manner governed by signal to noise ratio and dependent on GRK6. Current
Biology. Cell Press. https://doi.org/10.1016/j.cub.2017.04.004
chicago: Schwarz, Jan, Veronika Bierbaum, Kari Vaahtomeri, Robert Hauschild, Markus
Brown, Ingrid de Vries, Alexander F Leithner, et al. “Dendritic Cells Interpret
Haptotactic Chemokine Gradients in a Manner Governed by Signal to Noise Ratio
and Dependent on GRK6.” Current Biology. Cell Press, 2017. https://doi.org/10.1016/j.cub.2017.04.004.
ieee: J. Schwarz et al., “Dendritic cells interpret haptotactic chemokine
gradients in a manner governed by signal to noise ratio and dependent on GRK6,”
Current Biology, vol. 27, no. 9. Cell Press, pp. 1314–1325, 2017.
ista: Schwarz J, Bierbaum V, Vaahtomeri K, Hauschild R, Brown M, de Vries I, Leithner
AF, Reversat A, Merrin J, Tarrant T, Bollenbach MT, Sixt MK. 2017. Dendritic cells
interpret haptotactic chemokine gradients in a manner governed by signal to noise
ratio and dependent on GRK6. Current Biology. 27(9), 1314–1325.
mla: Schwarz, Jan, et al. “Dendritic Cells Interpret Haptotactic Chemokine Gradients
in a Manner Governed by Signal to Noise Ratio and Dependent on GRK6.” Current
Biology, vol. 27, no. 9, Cell Press, 2017, pp. 1314–25, doi:10.1016/j.cub.2017.04.004.
short: J. Schwarz, V. Bierbaum, K. Vaahtomeri, R. Hauschild, M. Brown, I. de Vries,
A.F. Leithner, A. Reversat, J. Merrin, T. Tarrant, M.T. Bollenbach, M.K. Sixt,
Current Biology 27 (2017) 1314–1325.
date_created: 2018-12-11T11:47:51Z
date_published: 2017-05-09T00:00:00Z
date_updated: 2023-02-23T12:50:44Z
day: '09'
department:
- _id: MiSi
- _id: Bio
- _id: NanoFab
doi: 10.1016/j.cub.2017.04.004
ec_funded: 1
intvolume: ' 27'
issue: '9'
language:
- iso: eng
month: '05'
oa_version: None
page: 1314 - 1325
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
- _id: 25A8E5EA-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Y 564-B12
name: Cytoskeletal force generation and transduction of leukocytes (FWF)
publication: Current Biology
publication_identifier:
issn:
- '09609822'
publication_status: published
publisher: Cell Press
publist_id: '7050'
quality_controlled: '1'
scopus_import: 1
status: public
title: Dendritic cells interpret haptotactic chemokine gradients in a manner governed
by signal to noise ratio and dependent on GRK6
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 27
year: '2017'
...
---
_id: '677'
abstract:
- lang: eng
text: The INO80 complex (INO80-C) is an evolutionarily conserved nucleosome remodeler
that acts in transcription, replication, and genome stability. It is required
for resistance against genotoxic agents and is involved in the repair of DNA double-strand
breaks (DSBs) by homologous recombination (HR). However, the causes of the HR
defect in INO80-C mutant cells are controversial. Here, we unite previous findings
using a system to study HR with high spatial resolution in budding yeast. We find
that INO80-C has at least two distinct functions during HR—DNA end resection and
presynaptic filament formation. Importantly, the second function is linked to
the histone variant H2A.Z. In the absence of H2A.Z, presynaptic filament formation
and HR are restored in INO80-C-deficient mutants, suggesting that presynaptic
filament formation is the crucial INO80-C function during HR.
author:
- first_name: Claudio
full_name: Lademann, Claudio
last_name: Lademann
- first_name: Jörg
full_name: Renkawitz, Jörg
id: 3F0587C8-F248-11E8-B48F-1D18A9856A87
last_name: Renkawitz
orcid: 0000-0003-2856-3369
- first_name: Boris
full_name: Pfander, Boris
last_name: Pfander
- first_name: Stefan
full_name: Jentsch, Stefan
last_name: Jentsch
citation:
ama: Lademann C, Renkawitz J, Pfander B, Jentsch S. The INO80 complex removes H2A.Z
to promote presynaptic filament formation during homologous recombination. Cell
Reports. 2017;19(7):1294-1303. doi:10.1016/j.celrep.2017.04.051
apa: Lademann, C., Renkawitz, J., Pfander, B., & Jentsch, S. (2017). The INO80
complex removes H2A.Z to promote presynaptic filament formation during homologous
recombination. Cell Reports. Cell Press. https://doi.org/10.1016/j.celrep.2017.04.051
chicago: Lademann, Claudio, Jörg Renkawitz, Boris Pfander, and Stefan Jentsch. “The
INO80 Complex Removes H2A.Z to Promote Presynaptic Filament Formation during Homologous
Recombination.” Cell Reports. Cell Press, 2017. https://doi.org/10.1016/j.celrep.2017.04.051.
ieee: C. Lademann, J. Renkawitz, B. Pfander, and S. Jentsch, “The INO80 complex
removes H2A.Z to promote presynaptic filament formation during homologous recombination,”
Cell Reports, vol. 19, no. 7. Cell Press, pp. 1294–1303, 2017.
ista: Lademann C, Renkawitz J, Pfander B, Jentsch S. 2017. The INO80 complex removes
H2A.Z to promote presynaptic filament formation during homologous recombination.
Cell Reports. 19(7), 1294–1303.
mla: Lademann, Claudio, et al. “The INO80 Complex Removes H2A.Z to Promote Presynaptic
Filament Formation during Homologous Recombination.” Cell Reports, vol.
19, no. 7, Cell Press, 2017, pp. 1294–303, doi:10.1016/j.celrep.2017.04.051.
short: C. Lademann, J. Renkawitz, B. Pfander, S. Jentsch, Cell Reports 19 (2017)
1294–1303.
date_created: 2018-12-11T11:47:52Z
date_published: 2017-05-16T00:00:00Z
date_updated: 2021-01-12T08:08:57Z
day: '16'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.1016/j.celrep.2017.04.051
file:
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checksum: efc7287d9c6354983cb151880e9ad72a
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:48Z
date_updated: 2020-07-14T12:47:40Z
file_id: '5171'
file_name: IST-2017-899-v1+1_1-s2.0-S2211124717305454-main.pdf
file_size: 3005610
relation: main_file
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has_accepted_license: '1'
intvolume: ' 19'
issue: '7'
language:
- iso: eng
month: '05'
oa: 1
oa_version: Published Version
page: 1294 - 1303
publication: Cell Reports
publication_identifier:
issn:
- '22111247'
publication_status: published
publisher: Cell Press
publist_id: '7046'
pubrep_id: '899'
quality_controlled: '1'
scopus_import: 1
status: public
title: The INO80 complex removes H2A.Z to promote presynaptic filament formation during
homologous recombination
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2017'
...
---
_id: '678'
abstract:
- lang: eng
text: The seminal observation that mechanical signals can elicit changes in biochemical
signalling within cells, a process commonly termed mechanosensation and mechanotransduction,
has revolutionized our understanding of the role of cell mechanics in various
fundamental biological processes, such as cell motility, adhesion, proliferation
and differentiation. In this Review, we will discuss how the interplay and feedback
between mechanical and biochemical signals control tissue morphogenesis and cell
fate specification in embryonic development.
author:
- first_name: Nicoletta
full_name: Petridou, Nicoletta
id: 2A003F6C-F248-11E8-B48F-1D18A9856A87
last_name: Petridou
orcid: 0000-0002-8451-1195
- first_name: Zoltan P
full_name: Spiro, Zoltan P
id: 426AD026-F248-11E8-B48F-1D18A9856A87
last_name: Spiro
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Petridou N, Spiro ZP, Heisenberg C-PJ. Multiscale force sensing in development.
Nature Cell Biology. 2017;19(6):581-588. doi:10.1038/ncb3524
apa: Petridou, N., Spiro, Z. P., & Heisenberg, C.-P. J. (2017). Multiscale force
sensing in development. Nature Cell Biology. Nature Publishing Group. https://doi.org/10.1038/ncb3524
chicago: Petridou, Nicoletta, Zoltan P Spiro, and Carl-Philipp J Heisenberg. “Multiscale
Force Sensing in Development.” Nature Cell Biology. Nature Publishing Group,
2017. https://doi.org/10.1038/ncb3524.
ieee: N. Petridou, Z. P. Spiro, and C.-P. J. Heisenberg, “Multiscale force sensing
in development,” Nature Cell Biology, vol. 19, no. 6. Nature Publishing
Group, pp. 581–588, 2017.
ista: Petridou N, Spiro ZP, Heisenberg C-PJ. 2017. Multiscale force sensing in development.
Nature Cell Biology. 19(6), 581–588.
mla: Petridou, Nicoletta, et al. “Multiscale Force Sensing in Development.” Nature
Cell Biology, vol. 19, no. 6, Nature Publishing Group, 2017, pp. 581–88, doi:10.1038/ncb3524.
short: N. Petridou, Z.P. Spiro, C.-P.J. Heisenberg, Nature Cell Biology 19 (2017)
581–588.
date_created: 2018-12-11T11:47:53Z
date_published: 2017-05-31T00:00:00Z
date_updated: 2021-01-12T08:08:59Z
day: '31'
department:
- _id: CaHe
doi: 10.1038/ncb3524
intvolume: ' 19'
issue: '6'
language:
- iso: eng
month: '05'
oa_version: None
page: 581 - 588
project:
- _id: 25236028-B435-11E9-9278-68D0E5697425
grant_number: ALTF534-2016
name: The generation and function of anisotropic tissue tension in zebrafish epiboly
(EMBO Fellowship)
publication: Nature Cell Biology
publication_identifier:
issn:
- '14657392'
publication_status: published
publisher: Nature Publishing Group
publist_id: '7040'
quality_controlled: '1'
scopus_import: 1
status: public
title: Multiscale force sensing in development
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 19
year: '2017'
...
---
_id: '681'
abstract:
- lang: eng
text: Two-player games on graphs provide the theoretical framework for many important
problems such as reactive synthesis. While the traditional study of two-player
zero-sum games has been extended to multi-player games with several notions of
equilibria, they are decidable only for perfect-information games, whereas several
applications require imperfect-information. In this paper we propose a new notion
of equilibria, called doomsday equilibria, which is a strategy profile where all
players satisfy their own objective, and if any coalition of players deviates
and violates even one of the players' objective, then the objective of every player
is violated. We present algorithms and complexity results for deciding the existence
of doomsday equilibria for various classes of ω-regular objectives, both for imperfect-information
games, and for perfect-information games. We provide optimal complexity bounds
for imperfect-information games, and in most cases for perfect-information games.
article_processing_charge: No
article_type: original
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Laurent
full_name: Doyen, Laurent
last_name: Doyen
- first_name: Emmanuel
full_name: Filiot, Emmanuel
last_name: Filiot
- first_name: Jean
full_name: Raskin, Jean
last_name: Raskin
citation:
ama: Chatterjee K, Doyen L, Filiot E, Raskin J. Doomsday equilibria for omega-regular
games. Information and Computation. 2017;254:296-315. doi:10.1016/j.ic.2016.10.012
apa: Chatterjee, K., Doyen, L., Filiot, E., & Raskin, J. (2017). Doomsday equilibria
for omega-regular games. Information and Computation. Elsevier. https://doi.org/10.1016/j.ic.2016.10.012
chicago: Chatterjee, Krishnendu, Laurent Doyen, Emmanuel Filiot, and Jean Raskin.
“Doomsday Equilibria for Omega-Regular Games.” Information and Computation.
Elsevier, 2017. https://doi.org/10.1016/j.ic.2016.10.012.
ieee: K. Chatterjee, L. Doyen, E. Filiot, and J. Raskin, “Doomsday equilibria for
omega-regular games,” Information and Computation, vol. 254. Elsevier,
pp. 296–315, 2017.
ista: Chatterjee K, Doyen L, Filiot E, Raskin J. 2017. Doomsday equilibria for omega-regular
games. Information and Computation. 254, 296–315.
mla: Chatterjee, Krishnendu, et al. “Doomsday Equilibria for Omega-Regular Games.”
Information and Computation, vol. 254, Elsevier, 2017, pp. 296–315, doi:10.1016/j.ic.2016.10.012.
short: K. Chatterjee, L. Doyen, E. Filiot, J. Raskin, Information and Computation
254 (2017) 296–315.
date_created: 2018-12-11T11:47:53Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2023-02-21T16:06:02Z
day: '01'
department:
- _id: KrCh
doi: 10.1016/j.ic.2016.10.012
ec_funded: 1
external_id:
arxiv:
- '1311.3238'
intvolume: ' 254'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1311.3238
month: '06'
oa: 1
oa_version: Submitted Version
page: 296 - 315
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Information and Computation
publication_identifier:
issn:
- '08905401'
publication_status: published
publisher: Elsevier
publist_id: '7036'
quality_controlled: '1'
related_material:
record:
- id: '10885'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Doomsday equilibria for omega-regular games
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 254
year: '2017'
...
---
_id: '6841'
abstract:
- lang: eng
text: In classical machine learning, regression is treated as a black box process
of identifying a suitable function from a hypothesis set without attempting to
gain insight into the mechanism connecting inputs and outputs. In the natural
sciences, however, finding an interpretable function for a phenomenon is the prime
goal as it allows to understand and generalize results. This paper proposes a
novel type of function learning network, called equation learner (EQL), that can
learn analytical expressions and is able to extrapolate to unseen domains. It
is implemented as an end-to-end differentiable feed-forward network and allows
for efficient gradient based training. Due to sparsity regularization concise
interpretable expressions can be obtained. Often the true underlying source expression
is identified.
author:
- first_name: Georg S
full_name: Martius, Georg S
id: 3A276B68-F248-11E8-B48F-1D18A9856A87
last_name: Martius
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
citation:
ama: 'Martius GS, Lampert C. Extrapolation and learning equations. In: 5th International
Conference on Learning Representations, ICLR 2017 - Workshop Track Proceedings.
International Conference on Learning Representations; 2017.'
apa: 'Martius, G. S., & Lampert, C. (2017). Extrapolation and learning equations.
In 5th International Conference on Learning Representations, ICLR 2017 - Workshop
Track Proceedings. Toulon, France: International Conference on Learning Representations.'
chicago: Martius, Georg S, and Christoph Lampert. “Extrapolation and Learning Equations.”
In 5th International Conference on Learning Representations, ICLR 2017 - Workshop
Track Proceedings. International Conference on Learning Representations, 2017.
ieee: G. S. Martius and C. Lampert, “Extrapolation and learning equations,” in 5th
International Conference on Learning Representations, ICLR 2017 - Workshop Track
Proceedings, Toulon, France, 2017.
ista: 'Martius GS, Lampert C. 2017. Extrapolation and learning equations. 5th International
Conference on Learning Representations, ICLR 2017 - Workshop Track Proceedings.
ICLR: International Conference on Learning Representations.'
mla: Martius, Georg S., and Christoph Lampert. “Extrapolation and Learning Equations.”
5th International Conference on Learning Representations, ICLR 2017 - Workshop
Track Proceedings, International Conference on Learning Representations, 2017.
short: G.S. Martius, C. Lampert, in:, 5th International Conference on Learning Representations,
ICLR 2017 - Workshop Track Proceedings, International Conference on Learning Representations,
2017.
conference:
end_date: 2017-04-26
location: Toulon, France
name: 'ICLR: International Conference on Learning Representations'
start_date: 2017-04-24
date_created: 2019-09-01T22:01:00Z
date_published: 2017-02-21T00:00:00Z
date_updated: 2021-01-12T08:09:17Z
day: '21'
department:
- _id: ChLa
ec_funded: 1
external_id:
arxiv:
- '1610.02995'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1610.02995
month: '02'
oa: 1
oa_version: Preprint
project:
- _id: 2532554C-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '308036'
name: Lifelong Learning of Visual Scene Understanding
publication: 5th International Conference on Learning Representations, ICLR 2017 -
Workshop Track Proceedings
publication_status: published
publisher: International Conference on Learning Representations
quality_controlled: '1'
scopus_import: 1
status: public
title: Extrapolation and learning equations
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
year: '2017'
...
---
_id: '684'
abstract:
- lang: eng
text: We generalize winning conditions in two-player games by adding a structural
acceptance condition called obligations. Obligations are orthogonal to the linear
winning conditions that define whether a play is winning. Obligations are a declaration
that player 0 can achieve a certain value from a configuration. If the obligation
is met, the value of that configuration for player 0 is 1. We define the value
in such games and show that obligation games are determined. For Markov chains
with Borel objectives and obligations, and finite turn-based stochastic parity
games with obligations we give an alternative and simpler characterization of
the value function. Based on this simpler definition we show that the decision
problem of winning finite turn-based stochastic parity games with obligations
is in NP∩co-NP. We also show that obligation games provide a game framework for
reasoning about p-automata. © 2017 The Association for Symbolic Logic.
article_processing_charge: No
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Nir
full_name: Piterman, Nir
last_name: Piterman
citation:
ama: Chatterjee K, Piterman N. Obligation blackwell games and p-automata. Journal
of Symbolic Logic. 2017;82(2):420-452. doi:10.1017/jsl.2016.71
apa: Chatterjee, K., & Piterman, N. (2017). Obligation blackwell games and p-automata.
Journal of Symbolic Logic. Cambridge University Press. https://doi.org/10.1017/jsl.2016.71
chicago: Chatterjee, Krishnendu, and Nir Piterman. “Obligation Blackwell Games and
P-Automata.” Journal of Symbolic Logic. Cambridge University Press, 2017.
https://doi.org/10.1017/jsl.2016.71.
ieee: K. Chatterjee and N. Piterman, “Obligation blackwell games and p-automata,”
Journal of Symbolic Logic, vol. 82, no. 2. Cambridge University Press,
pp. 420–452, 2017.
ista: Chatterjee K, Piterman N. 2017. Obligation blackwell games and p-automata.
Journal of Symbolic Logic. 82(2), 420–452.
mla: Chatterjee, Krishnendu, and Nir Piterman. “Obligation Blackwell Games and P-Automata.”
Journal of Symbolic Logic, vol. 82, no. 2, Cambridge University Press,
2017, pp. 420–52, doi:10.1017/jsl.2016.71.
short: K. Chatterjee, N. Piterman, Journal of Symbolic Logic 82 (2017) 420–452.
date_created: 2018-12-11T11:47:54Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2021-04-16T12:10:53Z
day: '01'
department:
- _id: KrCh
doi: 10.1017/jsl.2016.71
intvolume: ' 82'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1206.5174
month: '06'
oa: 1
oa_version: Submitted Version
page: 420 - 452
publication: Journal of Symbolic Logic
publication_identifier:
eissn:
- 1943-5886
issn:
- 0022-4812
publication_status: published
publisher: Cambridge University Press
publist_id: '7026'
quality_controlled: '1'
scopus_import: '1'
status: public
title: Obligation blackwell games and p-automata
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 82
year: '2017'
...
---
_id: '685'
abstract:
- lang: eng
text: By applying methods and principles from the physical sciences to biological
problems, D'Arcy Thompson's On Growth and Form demonstrated how mathematical reasoning
reveals elegant, simple explanations for seemingly complex processes. This has
had a profound influence on subsequent generations of developmental biologists.
We discuss how this influence can be traced through twentieth century morphologists,
embryologists and theoreticians to current research that explores the molecular
and cellular mechanisms of tissue growth and patterning, including our own studies
of the vertebrate neural tube.
author:
- first_name: James
full_name: Briscoe, James
last_name: Briscoe
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
citation:
ama: Briscoe J, Kicheva A. The physics of development 100 years after D’Arcy Thompson’s
“on growth and form.” Mechanisms of Development. 2017;145:26-31. doi:10.1016/j.mod.2017.03.005
apa: Briscoe, J., & Kicheva, A. (2017). The physics of development 100 years
after D’Arcy Thompson’s “on growth and form.” Mechanisms of Development.
Elsevier. https://doi.org/10.1016/j.mod.2017.03.005
chicago: Briscoe, James, and Anna Kicheva. “The Physics of Development 100 Years
after D’Arcy Thompson’s ‘on Growth and Form.’” Mechanisms of Development.
Elsevier, 2017. https://doi.org/10.1016/j.mod.2017.03.005.
ieee: J. Briscoe and A. Kicheva, “The physics of development 100 years after D’Arcy
Thompson’s ‘on growth and form,’” Mechanisms of Development, vol. 145.
Elsevier, pp. 26–31, 2017.
ista: Briscoe J, Kicheva A. 2017. The physics of development 100 years after D’Arcy
Thompson’s “on growth and form”. Mechanisms of Development. 145, 26–31.
mla: Briscoe, James, and Anna Kicheva. “The Physics of Development 100 Years after
D’Arcy Thompson’s ‘on Growth and Form.’” Mechanisms of Development, vol.
145, Elsevier, 2017, pp. 26–31, doi:10.1016/j.mod.2017.03.005.
short: J. Briscoe, A. Kicheva, Mechanisms of Development 145 (2017) 26–31.
date_created: 2018-12-11T11:47:55Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2021-01-12T08:09:20Z
day: '01'
ddc:
- '571'
department:
- _id: AnKi
doi: 10.1016/j.mod.2017.03.005
ec_funded: 1
external_id:
pmid:
- '28366718'
file:
- access_level: open_access
checksum: 727043d2e4199fbef6b3704e6d1ac105
content_type: application/pdf
creator: dernst
date_created: 2019-04-17T07:58:48Z
date_updated: 2020-07-14T12:47:42Z
file_id: '6335'
file_name: 2017_Briscoe_Kicheva_and_DArcy_accepted_version.pdf
file_size: 652313
relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: ' 145'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Submitted Version
page: 26 - 31
pmid: 1
project:
- _id: B6FC0238-B512-11E9-945C-1524E6697425
call_identifier: H2020
grant_number: '680037'
name: Coordination of Patterning And Growth In the Spinal Cord
publication: Mechanisms of Development
publication_identifier:
issn:
- '09254773'
publication_status: published
publisher: Elsevier
publist_id: '7025'
pubrep_id: '985'
quality_controlled: '1'
scopus_import: 1
status: public
title: The physics of development 100 years after D'Arcy Thompson's “on growth and
form”
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 145
year: '2017'
...
---
_id: '688'
abstract:
- lang: eng
text: 'We show that the framework of topological data analysis can be extended from
metrics to general Bregman divergences, widening the scope of possible applications.
Examples are the Kullback - Leibler divergence, which is commonly used for comparing
text and images, and the Itakura - Saito divergence, popular for speech and sound.
In particular, we prove that appropriately generalized čech and Delaunay (alpha)
complexes capture the correct homotopy type, namely that of the corresponding
union of Bregman balls. Consequently, their filtrations give the correct persistence
diagram, namely the one generated by the uniformly growing Bregman balls. Moreover,
we show that unlike the metric setting, the filtration of Vietoris-Rips complexes
may fail to approximate the persistence diagram. We propose algorithms to compute
the thus generalized čech, Vietoris-Rips and Delaunay complexes and experimentally
test their efficiency. Lastly, we explain their surprisingly good performance
by making a connection with discrete Morse theory. '
alternative_title:
- LIPIcs
author:
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Hubert
full_name: Wagner, Hubert
id: 379CA8B8-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
citation:
ama: 'Edelsbrunner H, Wagner H. Topological data analysis with Bregman divergences.
In: Vol 77. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2017:391-3916.
doi:10.4230/LIPIcs.SoCG.2017.39'
apa: 'Edelsbrunner, H., & Wagner, H. (2017). Topological data analysis with
Bregman divergences (Vol. 77, pp. 391–3916). Presented at the Symposium on Computational
Geometry, SoCG, Brisbane, Australia: Schloss Dagstuhl - Leibniz-Zentrum für Informatik.
https://doi.org/10.4230/LIPIcs.SoCG.2017.39'
chicago: Edelsbrunner, Herbert, and Hubert Wagner. “Topological Data Analysis with
Bregman Divergences,” 77:391–3916. Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2017. https://doi.org/10.4230/LIPIcs.SoCG.2017.39.
ieee: H. Edelsbrunner and H. Wagner, “Topological data analysis with Bregman divergences,”
presented at the Symposium on Computational Geometry, SoCG, Brisbane, Australia,
2017, vol. 77, pp. 391–3916.
ista: Edelsbrunner H, Wagner H. 2017. Topological data analysis with Bregman divergences.
Symposium on Computational Geometry, SoCG, LIPIcs, vol. 77, 391–3916.
mla: Edelsbrunner, Herbert, and Hubert Wagner. Topological Data Analysis with
Bregman Divergences. Vol. 77, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2017, pp. 391–3916, doi:10.4230/LIPIcs.SoCG.2017.39.
short: H. Edelsbrunner, H. Wagner, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2017, pp. 391–3916.
conference:
end_date: 2017-07-07
location: Brisbane, Australia
name: Symposium on Computational Geometry, SoCG
start_date: 2017-07-04
date_created: 2018-12-11T11:47:56Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2021-01-12T08:09:26Z
day: '01'
ddc:
- '514'
- '516'
department:
- _id: HeEd
- _id: UlWa
doi: 10.4230/LIPIcs.SoCG.2017.39
file:
- access_level: open_access
checksum: 067ab0cb3f962bae6c3af6bf0094e0f3
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:11:03Z
date_updated: 2020-07-14T12:47:42Z
file_id: '4856'
file_name: IST-2017-895-v1+1_LIPIcs-SoCG-2017-39.pdf
file_size: 990546
relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: ' 77'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 391-3916
publication_identifier:
issn:
- '18688969'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '7021'
pubrep_id: '895'
quality_controlled: '1'
scopus_import: 1
status: public
title: Topological data analysis with Bregman divergences
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 77
year: '2017'
...
---
_id: '687'
abstract:
- lang: eng
text: Pursuing the similarity between the Kontsevich-Soibelman construction of the
cohomological Hall algebra (CoHA) of BPS states and Lusztig's construction of
canonical bases for quantum enveloping algebras, and the similarity between the
integrality conjecture for motivic Donaldson-Thomas invariants and the PBW theorem
for quantum enveloping algebras, we build a coproduct on the CoHA associated to
a quiver with potential. We also prove a cohomological dimensional reduction theorem,
further linking a special class of CoHAs with Yangians, and explaining how to
connect the study of character varieties with the study of CoHAs.
author:
- first_name: Ben
full_name: Davison, Ben
id: 4634AB1E-F248-11E8-B48F-1D18A9856A87
last_name: Davison
orcid: 0000-0002-8944-4390
citation:
ama: Davison B. The critical CoHA of a quiver with potential. Quarterly Journal
of Mathematics. 2017;68(2):635-703. doi:10.1093/qmath/haw053
apa: Davison, B. (2017). The critical CoHA of a quiver with potential. Quarterly
Journal of Mathematics. Oxford University Press. https://doi.org/10.1093/qmath/haw053
chicago: Davison, Ben. “The Critical CoHA of a Quiver with Potential.” Quarterly
Journal of Mathematics. Oxford University Press, 2017. https://doi.org/10.1093/qmath/haw053.
ieee: B. Davison, “The critical CoHA of a quiver with potential,” Quarterly Journal
of Mathematics, vol. 68, no. 2. Oxford University Press, pp. 635–703, 2017.
ista: Davison B. 2017. The critical CoHA of a quiver with potential. Quarterly Journal
of Mathematics. 68(2), 635–703.
mla: Davison, Ben. “The Critical CoHA of a Quiver with Potential.” Quarterly
Journal of Mathematics, vol. 68, no. 2, Oxford University Press, 2017, pp.
635–703, doi:10.1093/qmath/haw053.
short: B. Davison, Quarterly Journal of Mathematics 68 (2017) 635–703.
date_created: 2018-12-11T11:47:55Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2021-01-12T08:09:24Z
day: '01'
department:
- _id: TaHa
doi: 10.1093/qmath/haw053
ec_funded: 1
intvolume: ' 68'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1311.7172
month: '06'
oa: 1
oa_version: Submitted Version
page: 635 - 703
project:
- _id: 25E549F4-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '320593'
name: Arithmetic and physics of Higgs moduli spaces
publication: Quarterly Journal of Mathematics
publication_identifier:
issn:
- '00335606'
publication_status: published
publisher: Oxford University Press
publist_id: '7022'
quality_controlled: '1'
scopus_import: 1
status: public
title: The critical CoHA of a quiver with potential
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 68
year: '2017'
...
---
_id: '686'
abstract:
- lang: eng
text: Tissues are thought to behave like fluids with a given surface tension. Differences
in tissue surface tension (TST) have been proposed to trigger cell sorting and
tissue envelopment. D'Arcy Thompson in his seminal book ‘On Growth and Form’ has
introduced this concept of differential TST as a key physical mechanism dictating
tissue formation and organization within the developing organism. Over the past
century, many studies have picked up the concept of differential TST and analyzed
the role and cell biological basis of TST in development, underlining the importance
and influence of this concept in developmental biology.
author:
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: 'Heisenberg C-PJ. D’Arcy Thompson’s ‘on growth and form’: From soap bubbles
to tissue self organization. Mechanisms of Development. 2017;145:32-37.
doi:10.1016/j.mod.2017.03.006'
apa: 'Heisenberg, C.-P. J. (2017). D’Arcy Thompson’s ‘on growth and form’: From
soap bubbles to tissue self organization. Mechanisms of Development. Elsevier.
https://doi.org/10.1016/j.mod.2017.03.006'
chicago: 'Heisenberg, Carl-Philipp J. “D’Arcy Thompson’s ‘on Growth and Form’: From
Soap Bubbles to Tissue Self Organization.” Mechanisms of Development. Elsevier,
2017. https://doi.org/10.1016/j.mod.2017.03.006.'
ieee: 'C.-P. J. Heisenberg, “D’Arcy Thompson’s ‘on growth and form’: From soap bubbles
to tissue self organization,” Mechanisms of Development, vol. 145. Elsevier,
pp. 32–37, 2017.'
ista: 'Heisenberg C-PJ. 2017. D’Arcy Thompson’s ‘on growth and form’: From soap
bubbles to tissue self organization. Mechanisms of Development. 145, 32–37.'
mla: 'Heisenberg, Carl-Philipp J. “D’Arcy Thompson’s ‘on Growth and Form’: From
Soap Bubbles to Tissue Self Organization.” Mechanisms of Development, vol.
145, Elsevier, 2017, pp. 32–37, doi:10.1016/j.mod.2017.03.006.'
short: C.-P.J. Heisenberg, Mechanisms of Development 145 (2017) 32–37.
date_created: 2018-12-11T11:47:55Z
date_published: 2017-06-01T00:00:00Z
date_updated: 2021-01-12T08:09:23Z
day: '01'
department:
- _id: CaHe
doi: 10.1016/j.mod.2017.03.006
intvolume: ' 145'
language:
- iso: eng
month: '06'
oa_version: None
page: 32 - 37
publication: Mechanisms of Development
publication_identifier:
issn:
- '09254773'
publication_status: published
publisher: Elsevier
publist_id: '7024'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'D''Arcy Thompson''s ‘on growth and form’: From soap bubbles to tissue self
organization'
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 145
year: '2017'
...
---
_id: '689'
abstract:
- lang: eng
text: Rett syndrome modeling in monkey mirrors the human disorder.
article_number: eaan8196
author:
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
citation:
ama: Novarino G. Rett syndrome modeling goes simian. Science Translational Medicine.
2017;9(393). doi:10.1126/scitranslmed.aan8196
apa: Novarino, G. (2017). Rett syndrome modeling goes simian. Science Translational
Medicine. American Association for the Advancement of Science. https://doi.org/10.1126/scitranslmed.aan8196
chicago: Novarino, Gaia. “Rett Syndrome Modeling Goes Simian.” Science Translational
Medicine. American Association for the Advancement of Science, 2017. https://doi.org/10.1126/scitranslmed.aan8196.
ieee: G. Novarino, “Rett syndrome modeling goes simian,” Science Translational
Medicine, vol. 9, no. 393. American Association for the Advancement of Science,
2017.
ista: Novarino G. 2017. Rett syndrome modeling goes simian. Science Translational
Medicine. 9(393), eaan8196.
mla: Novarino, Gaia. “Rett Syndrome Modeling Goes Simian.” Science Translational
Medicine, vol. 9, no. 393, eaan8196, American Association for the Advancement
of Science, 2017, doi:10.1126/scitranslmed.aan8196.
short: G. Novarino, Science Translational Medicine 9 (2017).
date_created: 2018-12-11T11:47:56Z
date_published: 2017-06-07T00:00:00Z
date_updated: 2021-01-12T08:09:29Z
day: '07'
department:
- _id: GaNo
doi: 10.1126/scitranslmed.aan8196
intvolume: ' 9'
issue: '393'
language:
- iso: eng
month: '06'
oa_version: None
publication: Science Translational Medicine
publication_identifier:
issn:
- '19466234'
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '7019'
quality_controlled: '1'
scopus_import: 1
status: public
title: Rett syndrome modeling goes simian
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2017'
...
---
_id: '693'
abstract:
- lang: eng
text: 'Many central synapses contain a single presynaptic active zone and a single
postsynaptic density. Vesicular release statistics at such “simple synapses” indicate
that they contain a small complement of docking sites where vesicles repetitively
dock and fuse. In this work, we investigate functional and morphological aspects
of docking sites at simple synapses made between cerebellar parallel fibers and
molecular layer interneurons. Using immunogold labeling of SDS-treated freeze-fracture
replicas, we find that Cav2.1 channels form several clusters per active zone with
about nine channels per cluster. The mean value and range of intersynaptic variation
are similar for Cav2.1 cluster numbers and for functional estimates of docking-site
numbers obtained from the maximum numbers of released vesicles per action potential.
Both numbers grow in relation with synaptic size and decrease by a similar extent
with age between 2 wk and 4 wk postnatal. Thus, the mean docking-site numbers
were 3.15 at 2 wk (range: 1–10) and 2.03 at 4 wk (range: 1–4), whereas the mean
numbers of Cav2.1 clusters were 2.84 at 2 wk (range: 1–8) and 2.37 at 4 wk (range:
1–5). These changes were accompanied by decreases of miniature current amplitude
(from 93 pA to 56 pA), active-zone surface area (from 0.0427 μm2 to 0.0234 μm2),
and initial success rate (from 0.609 to 0.353), indicating a tightening of synaptic
transmission with development. Altogether, these results suggest a close correspondence
between the number of functionally defined vesicular docking sites and that of
clusters of voltage-gated calcium channels. '
article_processing_charge: Yes (in subscription journal)
author:
- first_name: Takafumi
full_name: Miki, Takafumi
last_name: Miki
- first_name: Walter
full_name: Kaufmann, Walter
id: 3F99E422-F248-11E8-B48F-1D18A9856A87
last_name: Kaufmann
orcid: 0000-0001-9735-5315
- first_name: Gerardo
full_name: Malagon, Gerardo
last_name: Malagon
- first_name: Laura
full_name: Gomez, Laura
last_name: Gomez
- first_name: Katsuhiko
full_name: Tabuchi, Katsuhiko
last_name: Tabuchi
- first_name: Masahiko
full_name: Watanabe, Masahiko
last_name: Watanabe
- first_name: Ryuichi
full_name: Shigemoto, Ryuichi
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Alain
full_name: Marty, Alain
last_name: Marty
citation:
ama: Miki T, Kaufmann W, Malagon G, et al. Numbers of presynaptic Ca2+ channel clusters
match those of functionally defined vesicular docking sites in single central
synapses. PNAS. 2017;114(26):E5246-E5255. doi:10.1073/pnas.1704470114
apa: Miki, T., Kaufmann, W., Malagon, G., Gomez, L., Tabuchi, K., Watanabe, M.,
… Marty, A. (2017). Numbers of presynaptic Ca2+ channel clusters match those of
functionally defined vesicular docking sites in single central synapses. PNAS.
National Academy of Sciences. https://doi.org/10.1073/pnas.1704470114
chicago: Miki, Takafumi, Walter Kaufmann, Gerardo Malagon, Laura Gomez, Katsuhiko
Tabuchi, Masahiko Watanabe, Ryuichi Shigemoto, and Alain Marty. “Numbers of Presynaptic
Ca2+ Channel Clusters Match Those of Functionally Defined Vesicular Docking Sites
in Single Central Synapses.” PNAS. National Academy of Sciences, 2017.
https://doi.org/10.1073/pnas.1704470114.
ieee: T. Miki et al., “Numbers of presynaptic Ca2+ channel clusters match
those of functionally defined vesicular docking sites in single central synapses,”
PNAS, vol. 114, no. 26. National Academy of Sciences, pp. E5246–E5255,
2017.
ista: Miki T, Kaufmann W, Malagon G, Gomez L, Tabuchi K, Watanabe M, Shigemoto R,
Marty A. 2017. Numbers of presynaptic Ca2+ channel clusters match those of functionally
defined vesicular docking sites in single central synapses. PNAS. 114(26), E5246–E5255.
mla: Miki, Takafumi, et al. “Numbers of Presynaptic Ca2+ Channel Clusters Match
Those of Functionally Defined Vesicular Docking Sites in Single Central Synapses.”
PNAS, vol. 114, no. 26, National Academy of Sciences, 2017, pp. E5246–55,
doi:10.1073/pnas.1704470114.
short: T. Miki, W. Kaufmann, G. Malagon, L. Gomez, K. Tabuchi, M. Watanabe, R. Shigemoto,
A. Marty, PNAS 114 (2017) E5246–E5255.
date_created: 2018-12-11T11:47:57Z
date_published: 2017-06-27T00:00:00Z
date_updated: 2023-02-23T12:54:57Z
day: '27'
ddc:
- '570'
department:
- _id: EM-Fac
- _id: RySh
doi: 10.1073/pnas.1704470114
external_id:
pmid:
- '28607047'
file:
- access_level: open_access
checksum: 2ab75d554f3df4a34d20fa8040589b7e
content_type: application/pdf
creator: kschuh
date_created: 2020-01-03T13:27:29Z
date_updated: 2020-07-14T12:47:44Z
file_id: '7223'
file_name: 2017_PNAS_Miki.pdf
file_size: 2721544
relation: main_file
file_date_updated: 2020-07-14T12:47:44Z
has_accepted_license: '1'
intvolume: ' 114'
issue: '26'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: E5246 - E5255
pmid: 1
publication: PNAS
publication_identifier:
issn:
- '00278424'
publication_status: published
publisher: National Academy of Sciences
publist_id: '7013'
quality_controlled: '1'
scopus_import: 1
status: public
title: Numbers of presynaptic Ca2+ channel clusters match those of functionally defined
vesicular docking sites in single central synapses
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 114
year: '2017'
...
---
_id: '694'
abstract:
- lang: eng
text: A change regarding the extent of adhesion - hereafter referred to as adhesion
plasticity - between adhesive and less-adhesive states of mammalian cells is important
for their behavior. To investigate adhesion plasticity, we have selected a stable
isogenic subpopulation of human MDA-MB-468 breast carcinoma cells growing in suspension.
These suspension cells are unable to re-adhere to various matrices or to contract
three-dimensional collagen lattices. By using transcriptome analysis, we identified
the focal adhesion protein tensin3 (Tns3) as a determinant of adhesion plasticity.
Tns3 is strongly reduced at mRNA and protein levels in suspension cells. Furthermore,
by transiently challenging breast cancer cells to grow under non-adherent conditions
markedly reduces Tns3 protein expression, which is regained upon re-adhesion.
Stable knockdown of Tns3 in parental MDA-MB-468 cells results in defective adhesion,
spreading and migration. Tns3-knockdown cells display impaired structure and dynamics
of focal adhesion complexes as determined by immunostaining. Restoration of Tns3
protein expression in suspension cells partially rescues adhesion and focal contact
composition. Our work identifies Tns3 as a crucial focal adhesion component regulated
by, and functionally contributing to, the switch between adhesive and non-adhesive
states in MDA-MB-468 cancer cells.
article_type: original
author:
- first_name: Astrid
full_name: Veß, Astrid
last_name: Veß
- first_name: Ulrich
full_name: Blache, Ulrich
last_name: Blache
- first_name: Laura
full_name: Leitner, Laura
last_name: Leitner
- first_name: Angela
full_name: Kurz, Angela
last_name: Kurz
- first_name: Anja
full_name: Ehrenpfordt, Anja
last_name: Ehrenpfordt
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
- first_name: Guido
full_name: Posern, Guido
last_name: Posern
citation:
ama: Veß A, Blache U, Leitner L, et al. A dual phenotype of MDA MB 468 cancer cells
reveals mutual regulation of tensin3 and adhesion plasticity. Journal of Cell
Science. 2017;130(13):2172-2184. doi:10.1242/jcs.200899
apa: Veß, A., Blache, U., Leitner, L., Kurz, A., Ehrenpfordt, A., Sixt, M. K., &
Posern, G. (2017). A dual phenotype of MDA MB 468 cancer cells reveals mutual
regulation of tensin3 and adhesion plasticity. Journal of Cell Science.
Company of Biologists. https://doi.org/10.1242/jcs.200899
chicago: Veß, Astrid, Ulrich Blache, Laura Leitner, Angela Kurz, Anja Ehrenpfordt,
Michael K Sixt, and Guido Posern. “A Dual Phenotype of MDA MB 468 Cancer Cells
Reveals Mutual Regulation of Tensin3 and Adhesion Plasticity.” Journal of Cell
Science. Company of Biologists, 2017. https://doi.org/10.1242/jcs.200899.
ieee: A. Veß et al., “A dual phenotype of MDA MB 468 cancer cells reveals
mutual regulation of tensin3 and adhesion plasticity,” Journal of Cell Science,
vol. 130, no. 13. Company of Biologists, pp. 2172–2184, 2017.
ista: Veß A, Blache U, Leitner L, Kurz A, Ehrenpfordt A, Sixt MK, Posern G. 2017.
A dual phenotype of MDA MB 468 cancer cells reveals mutual regulation of tensin3
and adhesion plasticity. Journal of Cell Science. 130(13), 2172–2184.
mla: Veß, Astrid, et al. “A Dual Phenotype of MDA MB 468 Cancer Cells Reveals Mutual
Regulation of Tensin3 and Adhesion Plasticity.” Journal of Cell Science,
vol. 130, no. 13, Company of Biologists, 2017, pp. 2172–84, doi:10.1242/jcs.200899.
short: A. Veß, U. Blache, L. Leitner, A. Kurz, A. Ehrenpfordt, M.K. Sixt, G. Posern,
Journal of Cell Science 130 (2017) 2172–2184.
date_created: 2018-12-11T11:47:58Z
date_published: 2017-07-01T00:00:00Z
date_updated: 2021-01-12T08:09:41Z
day: '01'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.1242/jcs.200899
external_id:
pmid:
- '28515231'
file:
- access_level: open_access
checksum: 42c81a0a4fc3128883b391c3af3f74bc
content_type: application/pdf
creator: dernst
date_created: 2019-10-24T09:43:56Z
date_updated: 2020-07-14T12:47:45Z
file_id: '6966'
file_name: 2017_CellScience_Vess.pdf
file_size: 10847596
relation: main_file
file_date_updated: 2020-07-14T12:47:45Z
has_accepted_license: '1'
intvolume: ' 130'
issue: '13'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 2172 - 2184
pmid: 1
publication: Journal of Cell Science
publication_identifier:
issn:
- '00219533'
publication_status: published
publisher: Company of Biologists
publist_id: '7008'
quality_controlled: '1'
scopus_import: 1
status: public
title: A dual phenotype of MDA MB 468 cancer cells reveals mutual regulation of tensin3
and adhesion plasticity
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 130
year: '2017'
...
---
_id: '697'
abstract:
- lang: eng
text: 'De, Trevisan and Tulsiani [CRYPTO 2010] show that every distribution over
n-bit strings which has constant statistical distance to uniform (e.g., the output
of a pseudorandom generator mapping n-1 to n bit strings), can be distinguished
from the uniform distribution with advantage epsilon by a circuit of size O( 2^n
epsilon^2). We generalize this result, showing that a distribution which has less
than k bits of min-entropy, can be distinguished from any distribution with k
bits of delta-smooth min-entropy with advantage epsilon by a circuit of size O(2^k
epsilon^2/delta^2). As a special case, this implies that any distribution with
support at most 2^k (e.g., the output of a pseudoentropy generator mapping k to
n bit strings) can be distinguished from any given distribution with min-entropy
k+1 with advantage epsilon by a circuit of size O(2^k epsilon^2). Our result thus
shows that pseudoentropy distributions face basically the same non-uniform attacks
as pseudorandom distributions. '
alternative_title:
- LIPIcs
article_number: '39'
author:
- first_name: Krzysztof Z
full_name: Pietrzak, Krzysztof Z
id: 3E04A7AA-F248-11E8-B48F-1D18A9856A87
last_name: Pietrzak
orcid: 0000-0002-9139-1654
- first_name: Maciej
full_name: Skórski, Maciej
id: EC09FA6A-02D0-11E9-8223-86B7C91467DD
last_name: Skórski
citation:
ama: 'Pietrzak KZ, Skórski M. Non uniform attacks against pseudoentropy. In: Vol
80. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2017. doi:10.4230/LIPIcs.ICALP.2017.39'
apa: 'Pietrzak, K. Z., & Skórski, M. (2017). Non uniform attacks against pseudoentropy
(Vol. 80). Presented at the ICALP: International Colloquium on Automata, Languages,
and Programming, Warsaw, Poland: Schloss Dagstuhl - Leibniz-Zentrum für Informatik.
https://doi.org/10.4230/LIPIcs.ICALP.2017.39'
chicago: Pietrzak, Krzysztof Z, and Maciej Skórski. “Non Uniform Attacks against
Pseudoentropy,” Vol. 80. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2017.
https://doi.org/10.4230/LIPIcs.ICALP.2017.39.
ieee: 'K. Z. Pietrzak and M. Skórski, “Non uniform attacks against pseudoentropy,”
presented at the ICALP: International Colloquium on Automata, Languages, and Programming,
Warsaw, Poland, 2017, vol. 80.'
ista: 'Pietrzak KZ, Skórski M. 2017. Non uniform attacks against pseudoentropy.
ICALP: International Colloquium on Automata, Languages, and Programming, LIPIcs,
vol. 80, 39.'
mla: Pietrzak, Krzysztof Z., and Maciej Skórski. Non Uniform Attacks against
Pseudoentropy. Vol. 80, 39, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2017, doi:10.4230/LIPIcs.ICALP.2017.39.
short: K.Z. Pietrzak, M. Skórski, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2017.
conference:
end_date: 2017-07-14
location: Warsaw, Poland
name: 'ICALP: International Colloquium on Automata, Languages, and Programming'
start_date: 2017-07-10
date_created: 2018-12-11T11:47:59Z
date_published: 2017-07-01T00:00:00Z
date_updated: 2021-01-12T08:11:15Z
day: '01'
ddc:
- '005'
department:
- _id: KrPi
doi: 10.4230/LIPIcs.ICALP.2017.39
ec_funded: 1
file:
- access_level: open_access
checksum: e95618a001692f1af2d68f5fde43bc1f
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:08:40Z
date_updated: 2020-07-14T12:47:46Z
file_id: '4701'
file_name: IST-2017-893-v1+1_LIPIcs-ICALP-2017-39.pdf
file_size: 601004
relation: main_file
file_date_updated: 2020-07-14T12:47:46Z
has_accepted_license: '1'
intvolume: ' 80'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '682815'
name: Teaching Old Crypto New Tricks
publication_identifier:
issn:
- '18688969'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '7003'
pubrep_id: '893'
quality_controlled: '1'
scopus_import: 1
status: public
title: Non uniform attacks against pseudoentropy
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 80
year: '2017'
...
---
_id: '698'
abstract:
- lang: eng
text: 'Extracellular matrix signals from the microenvironment regulate gene expression
patterns and cell behavior. Using a combination of experiments and geometric models,
we demonstrate correlations between cell geometry, three-dimensional (3D) organization
of chromosome territories, and gene expression. Fluorescence in situ hybridization
experiments showed that micropatterned fibroblasts cultured on anisotropic versus
isotropic substrates resulted in repositioning of specific chromosomes, which
contained genes that were differentially regulated by cell geometries. Experiments
combined with ellipsoid packing models revealed that the mechanosensitivity of
chromosomes was correlated with their orientation in the nucleus. Transcription
inhibition experiments suggested that the intermingling degree was more sensitive
to global changes in transcription than to chromosome radial positioning and its
orientations. These results suggested that cell geometry modulated 3D chromosome
arrangement, and their neighborhoods correlated with gene expression patterns
in a predictable manner. This is central to understanding geometric control of
genetic programs involved in cellular homeostasis and the associated diseases. '
author:
- first_name: Yejun
full_name: Wang, Yejun
last_name: Wang
- first_name: Mallika
full_name: Nagarajan, Mallika
last_name: Nagarajan
- first_name: Caroline
full_name: Uhler, Caroline
id: 49ADD78E-F248-11E8-B48F-1D18A9856A87
last_name: Uhler
orcid: 0000-0002-7008-0216
- first_name: Gv
full_name: Shivashankar, Gv
last_name: Shivashankar
citation:
ama: Wang Y, Nagarajan M, Uhler C, Shivashankar G. Orientation and repositioning
of chromosomes correlate with cell geometry dependent gene expression. Molecular
Biology of the Cell. 2017;28(14):1997-2009. doi:10.1091/mbc.E16-12-0825
apa: Wang, Y., Nagarajan, M., Uhler, C., & Shivashankar, G. (2017). Orientation
and repositioning of chromosomes correlate with cell geometry dependent gene expression.
Molecular Biology of the Cell. American Society for Cell Biology. https://doi.org/10.1091/mbc.E16-12-0825
chicago: Wang, Yejun, Mallika Nagarajan, Caroline Uhler, and Gv Shivashankar. “Orientation
and Repositioning of Chromosomes Correlate with Cell Geometry Dependent Gene Expression.”
Molecular Biology of the Cell. American Society for Cell Biology, 2017.
https://doi.org/10.1091/mbc.E16-12-0825.
ieee: Y. Wang, M. Nagarajan, C. Uhler, and G. Shivashankar, “Orientation and repositioning
of chromosomes correlate with cell geometry dependent gene expression,” Molecular
Biology of the Cell, vol. 28, no. 14. American Society for Cell Biology, pp.
1997–2009, 2017.
ista: Wang Y, Nagarajan M, Uhler C, Shivashankar G. 2017. Orientation and repositioning
of chromosomes correlate with cell geometry dependent gene expression. Molecular
Biology of the Cell. 28(14), 1997–2009.
mla: Wang, Yejun, et al. “Orientation and Repositioning of Chromosomes Correlate
with Cell Geometry Dependent Gene Expression.” Molecular Biology of the Cell,
vol. 28, no. 14, American Society for Cell Biology, 2017, pp. 1997–2009, doi:10.1091/mbc.E16-12-0825.
short: Y. Wang, M. Nagarajan, C. Uhler, G. Shivashankar, Molecular Biology of the
Cell 28 (2017) 1997–2009.
date_created: 2018-12-11T11:47:59Z
date_published: 2017-07-07T00:00:00Z
date_updated: 2021-01-12T08:11:17Z
day: '07'
ddc:
- '519'
department:
- _id: CaUh
doi: 10.1091/mbc.E16-12-0825
file:
- access_level: open_access
checksum: de01dac9e30970cfa6ae902480a4e04d
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:10:53Z
date_updated: 2020-07-14T12:47:46Z
file_id: '4844'
file_name: IST-2017-892-v1+1_Mol._Biol._Cell-2017-Wang-1997-2009.pdf
file_size: 1086097
relation: main_file
file_date_updated: 2020-07-14T12:47:46Z
has_accepted_license: '1'
intvolume: ' 28'
issue: '14'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '07'
oa: 1
oa_version: Published Version
page: 1997 - 2009
project:
- _id: 2530CA10-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Y 903-N35
name: 'Gaussian Graphical Models: Theory and Applications'
publication: Molecular Biology of the Cell
publication_identifier:
issn:
- '10591524'
publication_status: published
publisher: American Society for Cell Biology
publist_id: '7001'
pubrep_id: '892'
quality_controlled: '1'
scopus_import: 1
status: public
title: Orientation and repositioning of chromosomes correlate with cell geometry dependent
gene expression
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 28
year: '2017'
...
---
_id: '699'
abstract:
- lang: eng
text: 'In antagonistic symbioses, such as host–parasite interactions, one population’s
success is the other’s loss. In mutualistic symbioses, such as division of labor,
both parties can gain, but they might have different preferences over the possible
mutualistic arrangements. The rates of evolution of the two populations in a symbiosis
are important determinants of which population will be more successful: Faster
evolution is thought to be favored in antagonistic symbioses (the “Red Queen effect”),
but disfavored in certain mutualistic symbioses (the “Red King effect”). However,
it remains unclear which biological parameters drive these effects. Here, we analyze
the effects of the various determinants of evolutionary rate: generation time,
mutation rate, population size, and the intensity of natural selection. Our main
results hold for the case where mutation is infrequent. Slower evolution causes
a long-term advantage in an important class of mutualistic interactions. Surprisingly,
less intense selection is the strongest driver of this Red King effect, whereas
relative mutation rates and generation times have little effect. In antagonistic
interactions, faster evolution by any means is beneficial. Our results provide
insight into the demographic evolution of symbionts. '
author:
- first_name: Carl
full_name: Veller, Carl
last_name: Veller
- first_name: Laura
full_name: Hayward, Laura
last_name: Hayward
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
- first_name: Christian
full_name: Hilbe, Christian
id: 2FDF8F3C-F248-11E8-B48F-1D18A9856A87
last_name: Hilbe
orcid: 0000-0001-5116-955X
citation:
ama: Veller C, Hayward L, Nowak M, Hilbe C. The red queen and king in finite populations.
PNAS. 2017;114(27):E5396-E5405. doi:10.1073/pnas.1702020114
apa: Veller, C., Hayward, L., Nowak, M., & Hilbe, C. (2017). The red queen and
king in finite populations. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.1702020114
chicago: Veller, Carl, Laura Hayward, Martin Nowak, and Christian Hilbe. “The Red
Queen and King in Finite Populations.” PNAS. National Academy of Sciences,
2017. https://doi.org/10.1073/pnas.1702020114.
ieee: C. Veller, L. Hayward, M. Nowak, and C. Hilbe, “The red queen and king in
finite populations,” PNAS, vol. 114, no. 27. National Academy of Sciences,
pp. E5396–E5405, 2017.
ista: Veller C, Hayward L, Nowak M, Hilbe C. 2017. The red queen and king in finite
populations. PNAS. 114(27), E5396–E5405.
mla: Veller, Carl, et al. “The Red Queen and King in Finite Populations.” PNAS,
vol. 114, no. 27, National Academy of Sciences, 2017, pp. E5396–405, doi:10.1073/pnas.1702020114.
short: C. Veller, L. Hayward, M. Nowak, C. Hilbe, PNAS 114 (2017) E5396–E5405.
date_created: 2018-12-11T11:48:00Z
date_published: 2017-07-03T00:00:00Z
date_updated: 2021-01-12T08:11:21Z
day: '03'
department:
- _id: KrCh
doi: 10.1073/pnas.1702020114
external_id:
pmid:
- '28630336'
intvolume: ' 114'
issue: '27'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5502615/
month: '07'
oa: 1
oa_version: Submitted Version
page: E5396 - E5405
pmid: 1
publication: PNAS
publication_identifier:
issn:
- '00278424'
publication_status: published
publisher: National Academy of Sciences
publist_id: '7002'
quality_controlled: '1'
scopus_import: 1
status: public
title: The red queen and king in finite populations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 114
year: '2017'
...
---
_id: '700'
abstract:
- lang: eng
text: Microtubules provide the mechanical force required for chromosome separation
during mitosis. However, little is known about the dynamic (high-frequency) mechanical
properties of microtubules. Here, we theoretically propose to control the vibrations
of a doubly clamped microtubule by tip electrodes and to detect its motion via
the optomechanical coupling between the vibrational modes of the microtubule and
an optical cavity. In the presence of a red-detuned strong pump laser, this coupling
leads to optomechanical-induced transparency of an optical probe field, which
can be detected with state-of-the art technology. The center frequency and line
width of the transparency peak give the resonance frequency and damping rate of
the microtubule, respectively, while the height of the peak reveals information
about the microtubule-cavity field coupling. Our method opens the new possibilities
to gain information about the physical properties of microtubules, which will
enhance our capability to design physical cancer treatment protocols as alternatives
to chemotherapeutic drugs.
article_number: '012404'
author:
- first_name: Shabir
full_name: Barzanjeh, Shabir
id: 2D25E1F6-F248-11E8-B48F-1D18A9856A87
last_name: Barzanjeh
orcid: 0000-0003-0415-1423
- first_name: Vahid
full_name: Salari, Vahid
last_name: Salari
- first_name: Jack
full_name: Tuszynski, Jack
last_name: Tuszynski
- first_name: Michal
full_name: Cifra, Michal
last_name: Cifra
- first_name: Christoph
full_name: Simon, Christoph
last_name: Simon
citation:
ama: Barzanjeh S, Salari V, Tuszynski J, Cifra M, Simon C. Optomechanical proposal
for monitoring microtubule mechanical vibrations. Physical Review E Statistical
Nonlinear and Soft Matter Physics . 2017;96(1). doi:10.1103/PhysRevE.96.012404
apa: Barzanjeh, S., Salari, V., Tuszynski, J., Cifra, M., & Simon, C. (2017).
Optomechanical proposal for monitoring microtubule mechanical vibrations.
Physical Review E Statistical Nonlinear and Soft Matter Physics . American
Institute of Physics. https://doi.org/10.1103/PhysRevE.96.012404
chicago: Barzanjeh, Shabir, Vahid Salari, Jack Tuszynski, Michal Cifra, and Christoph
Simon. “Optomechanical Proposal for Monitoring Microtubule Mechanical Vibrations.”
Physical Review E Statistical Nonlinear and Soft Matter Physics . American
Institute of Physics, 2017. https://doi.org/10.1103/PhysRevE.96.012404.
ieee: S. Barzanjeh, V. Salari, J. Tuszynski, M. Cifra, and C. Simon, “Optomechanical
proposal for monitoring microtubule mechanical vibrations,” Physical Review
E Statistical Nonlinear and Soft Matter Physics , vol. 96, no. 1. American
Institute of Physics, 2017.
ista: Barzanjeh S, Salari V, Tuszynski J, Cifra M, Simon C. 2017. Optomechanical
proposal for monitoring microtubule mechanical vibrations. Physical Review E
Statistical Nonlinear and Soft Matter Physics . 96(1), 012404.
mla: Barzanjeh, Shabir, et al. “Optomechanical Proposal for Monitoring Microtubule
Mechanical Vibrations.” Physical Review E Statistical Nonlinear and Soft Matter
Physics , vol. 96, no. 1, 012404, American Institute of Physics, 2017, doi:10.1103/PhysRevE.96.012404.
short: S. Barzanjeh, V. Salari, J. Tuszynski, M. Cifra, C. Simon, Physical Review
E Statistical Nonlinear and Soft Matter Physics 96 (2017).
date_created: 2018-12-11T11:48:00Z
date_published: 2017-07-12T00:00:00Z
date_updated: 2023-02-23T12:56:35Z
day: '12'
department:
- _id: JoFi
doi: 10.1103/PhysRevE.96.012404
ec_funded: 1
intvolume: ' 96'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/pdf/1612.07061.pdf
month: '07'
oa: 1
oa_version: Submitted Version
project:
- _id: 258047B6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '707438'
name: 'Microwave-to-Optical Quantum Link: Quantum Teleportation and Quantum Illumination
with cavity Optomechanics'
publication: ' Physical Review E Statistical Nonlinear and Soft Matter Physics '
publication_identifier:
issn:
- '24700045'
publication_status: published
publisher: American Institute of Physics
publist_id: '6997'
quality_controlled: '1'
scopus_import: 1
status: public
title: Optomechanical proposal for monitoring microtubule mechanical vibrations
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 96
year: '2017'
...
---
_id: '701'
abstract:
- lang: eng
text: A d-dimensional simplex S is called a k-reptile (or a k-reptile simplex) if
it can be tiled by k simplices with disjoint interiors that are all mutually congruent
and similar to S. For d = 2, triangular k-reptiles exist for all k of the form
a^2, 3a^2 or a^2+b^2 and they have been completely characterized by Snover, Waiveris,
and Williams. On the other hand, the only k-reptile simplices that are known for
d ≥ 3, have k = m^d, where m is a positive integer. We substantially simplify
the proof by Matoušek and the second author that for d = 3, k-reptile tetrahedra
can exist only for k = m^3. We then prove a weaker analogue of this result for
d = 4 by showing that four-dimensional k-reptile simplices can exist only for
k = m^2.
author:
- first_name: Jan
full_name: Kynčl, Jan
last_name: Kynčl
- first_name: Zuzana
full_name: Patakova, Zuzana
id: 48B57058-F248-11E8-B48F-1D18A9856A87
last_name: Patakova
orcid: 0000-0002-3975-1683
citation:
ama: Kynčl J, Patakova Z. On the nonexistence of k reptile simplices in ℝ^3 and
ℝ^4. The Electronic Journal of Combinatorics. 2017;24(3):1-44.
apa: Kynčl, J., & Patakova, Z. (2017). On the nonexistence of k reptile simplices
in ℝ^3 and ℝ^4. The Electronic Journal of Combinatorics. International
Press.
chicago: Kynčl, Jan, and Zuzana Patakova. “On the Nonexistence of k Reptile Simplices
in ℝ^3 and ℝ^4.” The Electronic Journal of Combinatorics. International
Press, 2017.
ieee: J. Kynčl and Z. Patakova, “On the nonexistence of k reptile simplices in ℝ^3
and ℝ^4,” The Electronic Journal of Combinatorics, vol. 24, no. 3. International
Press, pp. 1–44, 2017.
ista: Kynčl J, Patakova Z. 2017. On the nonexistence of k reptile simplices in ℝ^3
and ℝ^4. The Electronic Journal of Combinatorics. 24(3), 1–44.
mla: Kynčl, Jan, and Zuzana Patakova. “On the Nonexistence of k Reptile Simplices
in ℝ^3 and ℝ^4.” The Electronic Journal of Combinatorics, vol. 24, no.
3, International Press, 2017, pp. 1–44.
short: J. Kynčl, Z. Patakova, The Electronic Journal of Combinatorics 24 (2017)
1–44.
date_created: 2018-12-11T11:48:00Z
date_published: 2017-07-14T00:00:00Z
date_updated: 2021-01-12T08:11:28Z
day: '14'
ddc:
- '500'
department:
- _id: UlWa
file:
- access_level: open_access
checksum: a431e573e31df13bc0f66de3061006ec
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:14:25Z
date_updated: 2020-07-14T12:47:47Z
file_id: '5077'
file_name: IST-2018-984-v1+1_Patakova_on_the_nonexistence_of_k-reptile_simplices_in_R_3_and_R_4_2017.pdf
file_size: 544042
relation: main_file
file_date_updated: 2020-07-14T12:47:47Z
has_accepted_license: '1'
intvolume: ' 24'
issue: '3'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
page: 1-44
publication: The Electronic Journal of Combinatorics
publication_identifier:
issn:
- '10778926'
publication_status: published
publisher: International Press
publist_id: '6996'
pubrep_id: '984'
quality_controlled: '1'
status: public
title: On the nonexistence of k reptile simplices in ℝ^3 and ℝ^4
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 24
year: '2017'
...
---
_id: '702'
abstract:
- lang: eng
text: "Leading autism-associated mutation in mouse partially mimics human disorder.\r\n\r\n"
author:
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
citation:
ama: Novarino G. The riddle of CHD8 haploinsufficiency in autism spectrum disorder.
Science Translational Medicine. 2017;9(399):eaao0972. doi:10.1126/scitranslmed.aao0972
apa: Novarino, G. (2017). The riddle of CHD8 haploinsufficiency in autism spectrum
disorder. Science Translational Medicine. American Association for the
Advancement of Science. https://doi.org/10.1126/scitranslmed.aao0972
chicago: Novarino, Gaia. “The Riddle of CHD8 Haploinsufficiency in Autism Spectrum
Disorder.” Science Translational Medicine. American Association for the
Advancement of Science, 2017. https://doi.org/10.1126/scitranslmed.aao0972.
ieee: G. Novarino, “The riddle of CHD8 haploinsufficiency in autism spectrum disorder,”
Science Translational Medicine, vol. 9, no. 399. American Association for
the Advancement of Science, p. eaao0972, 2017.
ista: Novarino G. 2017. The riddle of CHD8 haploinsufficiency in autism spectrum
disorder. Science Translational Medicine. 9(399), eaao0972.
mla: Novarino, Gaia. “The Riddle of CHD8 Haploinsufficiency in Autism Spectrum Disorder.”
Science Translational Medicine, vol. 9, no. 399, American Association for
the Advancement of Science, 2017, p. eaao0972, doi:10.1126/scitranslmed.aao0972.
short: G. Novarino, Science Translational Medicine 9 (2017) eaao0972.
date_created: 2018-12-11T11:48:01Z
date_published: 2017-07-19T00:00:00Z
date_updated: 2021-01-12T08:11:31Z
day: '19'
department:
- _id: GaNo
doi: 10.1126/scitranslmed.aao0972
intvolume: ' 9'
issue: '399'
language:
- iso: eng
month: '07'
oa_version: None
page: eaao0972
publication: Science Translational Medicine
publication_identifier:
issn:
- '19466234'
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '6993'
quality_controlled: '1'
scopus_import: 1
status: public
title: The riddle of CHD8 haploinsufficiency in autism spectrum disorder
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2017'
...
---
_id: '706'
abstract:
- lang: eng
text: A hippocampal mossy fiber synapse has a complex structure and is implicated
in learning and memory. In this synapse, the mossy fiber boutons attach to the
dendritic shaft by puncta adherentia junctions and wrap around a multiply-branched
spine, forming synaptic junctions. We have recently shown using transmission electron
microscopy, immunoelectron microscopy and serial block face-scanning electron
microscopy that atypical puncta adherentia junctions are formed in the afadin-deficient
mossy fiber synapse and that the complexity of postsynaptic spines and mossy fiber
boutons, the number of spine heads, the area of postsynaptic densities and the
density of synaptic vesicles docked to active zones are decreased in the afadin-deficient
synapse. We investigated here the roles of afadin in the functional differentiations
of the mossy fiber synapse using the afadin-deficient mice. The electrophysiological
studies showed that both the release probability of glutamate and the postsynaptic
responsiveness to glutamate were markedly reduced, but not completely lost, in
the afadin-deficient mossy fiber synapse, whereas neither long-term potentiation
nor long-term depression was affected. These results indicate that afadin plays
roles in the functional differentiations of the presynapse and the postsynapse
of the hippocampal mossy fiber synapse.
author:
- first_name: Xiaoqi
full_name: Geng, Xiaoqi
id: 3395256A-F248-11E8-B48F-1D18A9856A87
last_name: Geng
- first_name: Tomohiko
full_name: Maruo, Tomohiko
last_name: Maruo
- first_name: Kenji
full_name: Mandai, Kenji
last_name: Mandai
- first_name: Irwan
full_name: Supriyanto, Irwan
last_name: Supriyanto
- first_name: Muneaki
full_name: Miyata, Muneaki
last_name: Miyata
- first_name: Shotaro
full_name: Sakakibara, Shotaro
last_name: Sakakibara
- first_name: Akira
full_name: Mizoguchi, Akira
last_name: Mizoguchi
- first_name: Yoshimi
full_name: Takai, Yoshimi
last_name: Takai
- first_name: Masahiro
full_name: Mori, Masahiro
last_name: Mori
citation:
ama: Geng X, Maruo T, Mandai K, et al. Roles of afadin in functional differentiations
of hippocampal mossy fiber synapse. Genes to Cells. 2017;22(8):715-722.
doi:10.1111/gtc.12508
apa: Geng, X., Maruo, T., Mandai, K., Supriyanto, I., Miyata, M., Sakakibara, S.,
… Mori, M. (2017). Roles of afadin in functional differentiations of hippocampal
mossy fiber synapse. Genes to Cells. Wiley-Blackwell. https://doi.org/10.1111/gtc.12508
chicago: Geng, Xiaoqi, Tomohiko Maruo, Kenji Mandai, Irwan Supriyanto, Muneaki Miyata,
Shotaro Sakakibara, Akira Mizoguchi, Yoshimi Takai, and Masahiro Mori. “Roles
of Afadin in Functional Differentiations of Hippocampal Mossy Fiber Synapse.”
Genes to Cells. Wiley-Blackwell, 2017. https://doi.org/10.1111/gtc.12508.
ieee: X. Geng et al., “Roles of afadin in functional differentiations of
hippocampal mossy fiber synapse,” Genes to Cells, vol. 22, no. 8. Wiley-Blackwell,
pp. 715–722, 2017.
ista: Geng X, Maruo T, Mandai K, Supriyanto I, Miyata M, Sakakibara S, Mizoguchi
A, Takai Y, Mori M. 2017. Roles of afadin in functional differentiations of hippocampal
mossy fiber synapse. Genes to Cells. 22(8), 715–722.
mla: Geng, Xiaoqi, et al. “Roles of Afadin in Functional Differentiations of Hippocampal
Mossy Fiber Synapse.” Genes to Cells, vol. 22, no. 8, Wiley-Blackwell,
2017, pp. 715–22, doi:10.1111/gtc.12508.
short: X. Geng, T. Maruo, K. Mandai, I. Supriyanto, M. Miyata, S. Sakakibara, A.
Mizoguchi, Y. Takai, M. Mori, Genes to Cells 22 (2017) 715–722.
date_created: 2018-12-11T11:48:02Z
date_published: 2017-08-01T00:00:00Z
date_updated: 2021-01-12T08:11:37Z
day: '01'
department:
- _id: PeJo
doi: 10.1111/gtc.12508
intvolume: ' 22'
issue: '8'
language:
- iso: eng
month: '08'
oa_version: None
page: 715 - 722
publication: Genes to Cells
publication_identifier:
issn:
- '13569597'
publication_status: published
publisher: Wiley-Blackwell
publist_id: '6987'
quality_controlled: '1'
scopus_import: 1
status: public
title: Roles of afadin in functional differentiations of hippocampal mossy fiber synapse
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 22
year: '2017'
...
---
_id: '707'
abstract:
- lang: eng
text: We answer a question of M. Gromov on the waist of the unit ball.
author:
- first_name: Arseniy
full_name: Akopyan, Arseniy
id: 430D2C90-F248-11E8-B48F-1D18A9856A87
last_name: Akopyan
orcid: 0000-0002-2548-617X
- first_name: Roman
full_name: Karasev, Roman
last_name: Karasev
citation:
ama: Akopyan A, Karasev R. A tight estimate for the waist of the ball . Bulletin
of the London Mathematical Society. 2017;49(4):690-693. doi:10.1112/blms.12062
apa: Akopyan, A., & Karasev, R. (2017). A tight estimate for the waist of the
ball . Bulletin of the London Mathematical Society. Wiley-Blackwell. https://doi.org/10.1112/blms.12062
chicago: Akopyan, Arseniy, and Roman Karasev. “A Tight Estimate for the Waist of
the Ball .” Bulletin of the London Mathematical Society. Wiley-Blackwell,
2017. https://doi.org/10.1112/blms.12062.
ieee: A. Akopyan and R. Karasev, “A tight estimate for the waist of the ball ,”
Bulletin of the London Mathematical Society, vol. 49, no. 4. Wiley-Blackwell,
pp. 690–693, 2017.
ista: Akopyan A, Karasev R. 2017. A tight estimate for the waist of the ball . Bulletin
of the London Mathematical Society. 49(4), 690–693.
mla: Akopyan, Arseniy, and Roman Karasev. “A Tight Estimate for the Waist of the
Ball .” Bulletin of the London Mathematical Society, vol. 49, no. 4, Wiley-Blackwell,
2017, pp. 690–93, doi:10.1112/blms.12062.
short: A. Akopyan, R. Karasev, Bulletin of the London Mathematical Society 49 (2017)
690–693.
date_created: 2018-12-11T11:48:02Z
date_published: 2017-08-01T00:00:00Z
date_updated: 2021-01-12T08:11:41Z
day: '01'
department:
- _id: HeEd
doi: 10.1112/blms.12062
ec_funded: 1
intvolume: ' 49'
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1608.06279
month: '08'
oa: 1
oa_version: Preprint
page: 690 - 693
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Bulletin of the London Mathematical Society
publication_identifier:
issn:
- '00246093'
publication_status: published
publisher: Wiley-Blackwell
publist_id: '6982'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'A tight estimate for the waist of the ball '
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 49
year: '2017'
...
---
_id: '708'
abstract:
- lang: eng
text: 'In the developing and adult brain, oligodendrocyte precursor cells (OPCs)
are influenced by neuronal activity: they are involved in synaptic signaling with
neurons, and their proliferation and differentiation into myelinating glia can
be altered by transient changes in neuronal firing. An important question that
has been unanswered is whether OPCs can discriminate different patterns of neuronal
activity and respond to them in a distinct way. Here, we demonstrate in brain
slices that the pattern of neuronal activity determines the functional changes
triggered at synapses between axons and OPCs. Furthermore, we show that stimulation
of the corpus callosum at different frequencies in vivo affects proliferation
and differentiation of OPCs in a dissimilar way. Our findings suggest that neurons
do not influence OPCs in “all-or-none” fashion but use their firing pattern to
tune the response and behavior of these nonneuronal cells.'
article_number: e2001993
author:
- first_name: Balint
full_name: Nagy, Balint
id: 30F830CE-02D1-11E9-9BAA-DAF4881429F2
last_name: Nagy
orcid: 0000-0002-4002-4686
- first_name: Anahit
full_name: Hovhannisyan, Anahit
last_name: Hovhannisyan
- first_name: Ruxandra
full_name: Barzan, Ruxandra
last_name: Barzan
- first_name: Ting
full_name: Chen, Ting
last_name: Chen
- first_name: Maria
full_name: Kukley, Maria
last_name: Kukley
citation:
ama: Nagy B, Hovhannisyan A, Barzan R, Chen T, Kukley M. Different patterns of neuronal
activity trigger distinct responses of oligodendrocyte precursor cells in the
corpus callosum. PLoS Biology. 2017;15(8). doi:10.1371/journal.pbio.2001993
apa: Nagy, B., Hovhannisyan, A., Barzan, R., Chen, T., & Kukley, M. (2017).
Different patterns of neuronal activity trigger distinct responses of oligodendrocyte
precursor cells in the corpus callosum. PLoS Biology. Public Library of
Science. https://doi.org/10.1371/journal.pbio.2001993
chicago: Nagy, Balint, Anahit Hovhannisyan, Ruxandra Barzan, Ting Chen, and Maria
Kukley. “Different Patterns of Neuronal Activity Trigger Distinct Responses of
Oligodendrocyte Precursor Cells in the Corpus Callosum.” PLoS Biology.
Public Library of Science, 2017. https://doi.org/10.1371/journal.pbio.2001993.
ieee: B. Nagy, A. Hovhannisyan, R. Barzan, T. Chen, and M. Kukley, “Different patterns
of neuronal activity trigger distinct responses of oligodendrocyte precursor cells
in the corpus callosum,” PLoS Biology, vol. 15, no. 8. Public Library of
Science, 2017.
ista: Nagy B, Hovhannisyan A, Barzan R, Chen T, Kukley M. 2017. Different patterns
of neuronal activity trigger distinct responses of oligodendrocyte precursor cells
in the corpus callosum. PLoS Biology. 15(8), e2001993.
mla: Nagy, Balint, et al. “Different Patterns of Neuronal Activity Trigger Distinct
Responses of Oligodendrocyte Precursor Cells in the Corpus Callosum.” PLoS
Biology, vol. 15, no. 8, e2001993, Public Library of Science, 2017, doi:10.1371/journal.pbio.2001993.
short: B. Nagy, A. Hovhannisyan, R. Barzan, T. Chen, M. Kukley, PLoS Biology 15
(2017).
date_created: 2018-12-11T11:48:03Z
date_published: 2017-08-22T00:00:00Z
date_updated: 2021-01-12T08:11:45Z
day: '22'
ddc:
- '576'
- '610'
department:
- _id: SaSi
doi: 10.1371/journal.pbio.2001993
file:
- access_level: open_access
checksum: 0c974f430682dc832ea7b27ab5a93124
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:35Z
date_updated: 2020-07-14T12:47:49Z
file_id: '5156'
file_name: IST-2017-889-v1+1_journal.pbio.2001993.pdf
file_size: 18155365
relation: main_file
file_date_updated: 2020-07-14T12:47:49Z
has_accepted_license: '1'
intvolume: ' 15'
issue: '8'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
publication: PLoS Biology
publication_identifier:
issn:
- '15449173'
publication_status: published
publisher: Public Library of Science
publist_id: '6983'
pubrep_id: '889'
quality_controlled: '1'
scopus_import: 1
status: public
title: Different patterns of neuronal activity trigger distinct responses of oligodendrocyte
precursor cells in the corpus callosum
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2017'
...
---
_id: '709'
abstract:
- lang: eng
text: Adipose tissues play key roles in energy homeostasis. Brown adipocytes and
beige adipocytes in white adipose tissue (WAT) share the similar characters of
thermogenesis, both of them could be potential targets for obesity management.
Several thermo-sensitive transient receptor potential channels (thermoTRPs) are
shown to be involved in adipocyte biology. However, the expression pattern of
thermoTRPs in adipose tissues from obese mice is still unknown. The mRNA expression
of thermoTRPs in subcutaneous WAT (sWAT) and interscapular brown adipose tissue
(iBAT) from lean and obese mice were measured using reverse transcriptase-quantitative
PCRs (RT-qPCR). The results demonstrated that all 10 thermoTRPs are expressed
in both iBAT and sWAT, and without significant difference in the mRNA expression
level of thermoTRPs between these two tissues. Moreover, Trpv1 and Trpv3 mRNA
expression levels in both iBAT and sWAT were significantly decreased in high fat
diet (HFD)-induced obese mice and db/db (leptin receptor deficient) mice. Trpm2
mRNA expression level was significantly decreased only in sWAT from HFD-induced
obese mice and db/db mice. On the other hand, Trpv2 and Trpv4 mRNA expression
levels in iBAT and sWAT were significantly increased in HFD-induced obese mice
and db/db mice. Taken together, we conclude that all 10 thermoTRPs are expressed
in iBAT and sWAT. And several thermoTRPs differentially expressed in adipose tissues
from HFD-induced obese mice and db/db mice, suggesting a potential involvement
in anti-obesity regulations.
author:
- first_name: Wuping
full_name: Sun, Wuping
last_name: Sun
- first_name: Chen
full_name: Li, Chen
last_name: Li
- first_name: Yonghong
full_name: Zhang, Yonghong
last_name: Zhang
- first_name: Changyu
full_name: Jiang, Changyu
last_name: Jiang
- first_name: Ming-Zhu
full_name: Zhai, Ming-Zhu
id: 34009CFA-F248-11E8-B48F-1D18A9856A87
last_name: Zhai
- first_name: Qian
full_name: Zhou, Qian
last_name: Zhou
- first_name: Lizu
full_name: Xiao, Lizu
last_name: Xiao
- first_name: Qiwen
full_name: Deng, Qiwen
last_name: Deng
citation:
ama: Sun W, Li C, Zhang Y, et al. Gene expression changes of thermo sensitive transient
receptor potential channels in obese mice. Cell Biology International.
2017;41(8):908-913. doi:10.1002/cbin.10783
apa: Sun, W., Li, C., Zhang, Y., Jiang, C., Zhai, M.-Z., Zhou, Q., … Deng, Q. (2017).
Gene expression changes of thermo sensitive transient receptor potential channels
in obese mice. Cell Biology International. Wiley-Blackwell. https://doi.org/10.1002/cbin.10783
chicago: Sun, Wuping, Chen Li, Yonghong Zhang, Changyu Jiang, Ming-Zhu Zhai, Qian
Zhou, Lizu Xiao, and Qiwen Deng. “Gene Expression Changes of Thermo Sensitive
Transient Receptor Potential Channels in Obese Mice.” Cell Biology International.
Wiley-Blackwell, 2017. https://doi.org/10.1002/cbin.10783.
ieee: W. Sun et al., “Gene expression changes of thermo sensitive transient
receptor potential channels in obese mice,” Cell Biology International,
vol. 41, no. 8. Wiley-Blackwell, pp. 908–913, 2017.
ista: Sun W, Li C, Zhang Y, Jiang C, Zhai M-Z, Zhou Q, Xiao L, Deng Q. 2017. Gene
expression changes of thermo sensitive transient receptor potential channels in
obese mice. Cell Biology International. 41(8), 908–913.
mla: Sun, Wuping, et al. “Gene Expression Changes of Thermo Sensitive Transient
Receptor Potential Channels in Obese Mice.” Cell Biology International,
vol. 41, no. 8, Wiley-Blackwell, 2017, pp. 908–13, doi:10.1002/cbin.10783.
short: W. Sun, C. Li, Y. Zhang, C. Jiang, M.-Z. Zhai, Q. Zhou, L. Xiao, Q. Deng,
Cell Biology International 41 (2017) 908–913.
date_created: 2018-12-11T11:48:04Z
date_published: 2017-08-01T00:00:00Z
date_updated: 2021-01-12T08:11:47Z
day: '01'
department:
- _id: RySh
doi: 10.1002/cbin.10783
intvolume: ' 41'
issue: '8'
language:
- iso: eng
month: '08'
oa_version: None
page: 908 - 913
publication: Cell Biology International
publication_identifier:
issn:
- '10656995'
publication_status: published
publisher: Wiley-Blackwell
publist_id: '6981'
quality_controlled: '1'
scopus_import: 1
status: public
title: Gene expression changes of thermo sensitive transient receptor potential channels
in obese mice
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 41
year: '2017'
...
---
_id: '710'
abstract:
- lang: eng
text: 'We revisit the problem of estimating entropy of discrete distributions from
independent samples, studied recently by Acharya, Orlitsky, Suresh and Tyagi (SODA
2015), improving their upper and lower bounds on the necessary sample size n.
For estimating Renyi entropy of order alpha, up to constant accuracy and error
probability, we show the following * Upper bounds n = O(1) 2^{(1-1/alpha)H_alpha}
for integer alpha>1, as the worst case over distributions with Renyi entropy
equal to H_alpha. * Lower bounds n = Omega(1) K^{1-1/alpha} for any real alpha>1,
with the constant being an inverse polynomial of the accuracy, as the worst case
over all distributions on K elements. Our upper bounds essentially replace the
alphabet size by a factor exponential in the entropy, which offers improvements
especially in low or medium entropy regimes (interesting for example in anomaly
detection). As for the lower bounds, our proof explicitly shows how the complexity
depends on both alphabet and accuracy, partially solving the open problem posted
in previous works. The argument for upper bounds derives a clean identity for
the variance of falling-power sum of a multinomial distribution. Our approach
for lower bounds utilizes convex optimization to find a distribution with possibly
worse estimation performance, and may be of independent interest as a tool to
work with Le Cam’s two point method. '
alternative_title:
- LIPIcs
article_number: '20'
author:
- first_name: Maciej
full_name: Obremski, Maciej
last_name: Obremski
- first_name: Maciej
full_name: Skórski, Maciej
id: EC09FA6A-02D0-11E9-8223-86B7C91467DD
last_name: Skórski
citation:
ama: 'Obremski M, Skórski M. Renyi entropy estimation revisited. In: Vol 81. Schloss
Dagstuhl - Leibniz-Zentrum für Informatik; 2017. doi:10.4230/LIPIcs.APPROX-RANDOM.2017.20'
apa: 'Obremski, M., & Skórski, M. (2017). Renyi entropy estimation revisited
(Vol. 81). Presented at the 20th International Workshop on Approximation Algorithms
for Combinatorial Optimization Problems, APPROX, Berkeley, USA: Schloss Dagstuhl
- Leibniz-Zentrum für Informatik. https://doi.org/10.4230/LIPIcs.APPROX-RANDOM.2017.20'
chicago: Obremski, Maciej, and Maciej Skórski. “Renyi Entropy Estimation Revisited,”
Vol. 81. Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2017. https://doi.org/10.4230/LIPIcs.APPROX-RANDOM.2017.20.
ieee: M. Obremski and M. Skórski, “Renyi entropy estimation revisited,” presented
at the 20th International Workshop on Approximation Algorithms for Combinatorial
Optimization Problems, APPROX, Berkeley, USA, 2017, vol. 81.
ista: Obremski M, Skórski M. 2017. Renyi entropy estimation revisited. 20th International
Workshop on Approximation Algorithms for Combinatorial Optimization Problems,
APPROX, LIPIcs, vol. 81, 20.
mla: Obremski, Maciej, and Maciej Skórski. Renyi Entropy Estimation Revisited.
Vol. 81, 20, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2017, doi:10.4230/LIPIcs.APPROX-RANDOM.2017.20.
short: M. Obremski, M. Skórski, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2017.
conference:
end_date: 2017-08-18
location: Berkeley, USA
name: 20th International Workshop on Approximation Algorithms for Combinatorial
Optimization Problems, APPROX
start_date: 2017-08-18
date_created: 2018-12-11T11:48:04Z
date_published: 2017-08-01T00:00:00Z
date_updated: 2021-01-12T08:11:50Z
day: '01'
ddc:
- '005'
- '600'
department:
- _id: KrPi
doi: 10.4230/LIPIcs.APPROX-RANDOM.2017.20
ec_funded: 1
file:
- access_level: open_access
checksum: 89225c7dcec2c93838458c9102858985
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:10Z
date_updated: 2020-07-14T12:47:49Z
file_id: '4991'
file_name: IST-2017-888-v1+1_LIPIcs-APPROX-RANDOM-2017-20.pdf
file_size: 604813
relation: main_file
file_date_updated: 2020-07-14T12:47:49Z
has_accepted_license: '1'
intvolume: ' 81'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 258AA5B2-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '682815'
name: Teaching Old Crypto New Tricks
publication_identifier:
issn:
- '18688969'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '6979'
pubrep_id: '888'
quality_controlled: '1'
scopus_import: 1
status: public
title: Renyi entropy estimation revisited
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 81
year: '2017'
...
---
_id: '713'
abstract:
- lang: eng
text: To determine the dynamics of allelic-specific expression during mouse development,
we analyzed RNA-seq data from 23 F1 tissues from different developmental stages,
including 19 female tissues allowing X chromosome inactivation (XCI) escapers
to also be detected. We demonstrate that allelic expression arising from genetic
or epigenetic differences is highly tissue-specific. We find that tissue-specific
strain-biased gene expression may be regulated by tissue-specific enhancers or
by post-transcriptional differences in stability between the alleles. We also
find that escape from X-inactivation is tissue-specific, with leg muscle showing
an unexpectedly high rate of XCI escapers. By surveying a range of tissues during
development, and performing extensive validation, we are able to provide a high
confidence list of mouse imprinted genes including 18 novel genes. This shows
that cluster size varies dynamically during development and can be substantially
larger than previously thought, with the Igf2r cluster extending over 10 Mb in
placenta.
article_number: e25125
author:
- first_name: Daniel
full_name: Andergassen, Daniel
last_name: Andergassen
- first_name: Christoph
full_name: Dotter, Christoph
id: 4C66542E-F248-11E8-B48F-1D18A9856A87
last_name: Dotter
- first_name: Dyniel
full_name: Wenzel, Dyniel
last_name: Wenzel
- first_name: Verena
full_name: Sigl, Verena
last_name: Sigl
- first_name: Philipp
full_name: Bammer, Philipp
last_name: Bammer
- first_name: Markus
full_name: Muckenhuber, Markus
last_name: Muckenhuber
- first_name: Daniela
full_name: Mayer, Daniela
last_name: Mayer
- first_name: Tomasz
full_name: Kulinski, Tomasz
last_name: Kulinski
- first_name: Hans
full_name: Theussl, Hans
last_name: Theussl
- first_name: Josef
full_name: Penninger, Josef
last_name: Penninger
- first_name: Christoph
full_name: Bock, Christoph
last_name: Bock
- first_name: Denise
full_name: Barlow, Denise
last_name: Barlow
- first_name: Florian
full_name: Pauler, Florian
id: 48EA0138-F248-11E8-B48F-1D18A9856A87
last_name: Pauler
- first_name: Quanah
full_name: Hudson, Quanah
last_name: Hudson
citation:
ama: Andergassen D, Dotter C, Wenzel D, et al. Mapping the mouse Allelome reveals
tissue specific regulation of allelic expression. eLife. 2017;6. doi:10.7554/eLife.25125
apa: Andergassen, D., Dotter, C., Wenzel, D., Sigl, V., Bammer, P., Muckenhuber,
M., … Hudson, Q. (2017). Mapping the mouse Allelome reveals tissue specific regulation
of allelic expression. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.25125
chicago: Andergassen, Daniel, Christoph Dotter, Dyniel Wenzel, Verena Sigl, Philipp
Bammer, Markus Muckenhuber, Daniela Mayer, et al. “Mapping the Mouse Allelome
Reveals Tissue Specific Regulation of Allelic Expression.” ELife. eLife
Sciences Publications, 2017. https://doi.org/10.7554/eLife.25125.
ieee: D. Andergassen et al., “Mapping the mouse Allelome reveals tissue specific
regulation of allelic expression,” eLife, vol. 6. eLife Sciences Publications,
2017.
ista: Andergassen D, Dotter C, Wenzel D, Sigl V, Bammer P, Muckenhuber M, Mayer
D, Kulinski T, Theussl H, Penninger J, Bock C, Barlow D, Pauler F, Hudson Q. 2017.
Mapping the mouse Allelome reveals tissue specific regulation of allelic expression.
eLife. 6, e25125.
mla: Andergassen, Daniel, et al. “Mapping the Mouse Allelome Reveals Tissue Specific
Regulation of Allelic Expression.” ELife, vol. 6, e25125, eLife Sciences
Publications, 2017, doi:10.7554/eLife.25125.
short: D. Andergassen, C. Dotter, D. Wenzel, V. Sigl, P. Bammer, M. Muckenhuber,
D. Mayer, T. Kulinski, H. Theussl, J. Penninger, C. Bock, D. Barlow, F. Pauler,
Q. Hudson, ELife 6 (2017).
date_created: 2018-12-11T11:48:05Z
date_published: 2017-08-14T00:00:00Z
date_updated: 2021-01-12T08:11:57Z
day: '14'
ddc:
- '576'
department:
- _id: GaNo
- _id: SiHi
doi: 10.7554/eLife.25125
file:
- access_level: open_access
checksum: 1ace3462e64a971b9ead896091829549
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:36Z
date_updated: 2020-07-14T12:47:50Z
file_id: '5020'
file_name: IST-2017-885-v1+1_elife-25125-figures-v2.pdf
file_size: 6399510
relation: main_file
- access_level: open_access
checksum: 6241dc31eeb87b03facadec3a53a6827
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:13:36Z
date_updated: 2020-07-14T12:47:50Z
file_id: '5021'
file_name: IST-2017-885-v1+2_elife-25125-v2.pdf
file_size: 4264398
relation: main_file
file_date_updated: 2020-07-14T12:47:50Z
has_accepted_license: '1'
intvolume: ' 6'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
project:
- _id: 25E9AF9E-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P27201-B22
name: Revealing the mechanisms underlying drug interactions
publication: eLife
publication_identifier:
issn:
- 2050084X
publication_status: published
publisher: eLife Sciences Publications
publist_id: '6971'
pubrep_id: '885'
quality_controlled: '1'
scopus_import: 1
status: public
title: Mapping the mouse Allelome reveals tissue specific regulation of allelic expression
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 6
year: '2017'
...
---
_id: '711'
abstract:
- lang: eng
text: Nested weighted automata (NWA) present a robust and convenient automata-theoretic
formalism for quantitative specifications. Previous works have considered NWA
that processed input words only in the forward direction. It is natural to allow
the automata to process input words backwards as well, for example, to measure
the maximal or average time between a response and the preceding request. We therefore
introduce and study bidirectional NWA that can process input words in both directions.
First, we show that bidirectional NWA can express interesting quantitative properties
that are not expressible by forward-only NWA. Second, for the fundamental decision
problems of emptiness and universality, we establish decidability and complexity
results for the new framework which match the best-known results for the special
case of forward-only NWA. Thus, for NWA, the increased expressiveness of bidirectionality
is achieved at no additional computational complexity. This is in stark contrast
to the unweighted case, where bidirectional finite automata are no more expressive
but exponentially more succinct than their forward-only counterparts.
alternative_title:
- LIPIcs
article_number: '5'
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Jan
full_name: Otop, Jan
last_name: Otop
citation:
ama: 'Chatterjee K, Henzinger TA, Otop J. Bidirectional nested weighted automata.
In: Vol 85. Schloss Dagstuhl - Leibniz-Zentrum für Informatik; 2017. doi:10.4230/LIPIcs.CONCUR.2017.5'
apa: 'Chatterjee, K., Henzinger, T. A., & Otop, J. (2017). Bidirectional nested
weighted automata (Vol. 85). Presented at the 28th International Conference on
Concurrency Theory, CONCUR, Berlin, Germany: Schloss Dagstuhl - Leibniz-Zentrum
für Informatik. https://doi.org/10.4230/LIPIcs.CONCUR.2017.5'
chicago: Chatterjee, Krishnendu, Thomas A Henzinger, and Jan Otop. “Bidirectional
Nested Weighted Automata,” Vol. 85. Schloss Dagstuhl - Leibniz-Zentrum für Informatik,
2017. https://doi.org/10.4230/LIPIcs.CONCUR.2017.5.
ieee: K. Chatterjee, T. A. Henzinger, and J. Otop, “Bidirectional nested weighted
automata,” presented at the 28th International Conference on Concurrency Theory,
CONCUR, Berlin, Germany, 2017, vol. 85.
ista: Chatterjee K, Henzinger TA, Otop J. 2017. Bidirectional nested weighted automata.
28th International Conference on Concurrency Theory, CONCUR, LIPIcs, vol. 85,
5.
mla: Chatterjee, Krishnendu, et al. Bidirectional Nested Weighted Automata.
Vol. 85, 5, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2017, doi:10.4230/LIPIcs.CONCUR.2017.5.
short: K. Chatterjee, T.A. Henzinger, J. Otop, in:, Schloss Dagstuhl - Leibniz-Zentrum
für Informatik, 2017.
conference:
end_date: 2017-09-08
location: Berlin, Germany
name: 28th International Conference on Concurrency Theory, CONCUR
start_date: 2017-09-05
date_created: 2018-12-11T11:48:04Z
date_published: 2017-08-01T00:00:00Z
date_updated: 2021-01-12T08:11:53Z
day: '01'
ddc:
- '004'
- '005'
department:
- _id: KrCh
- _id: ToHe
doi: 10.4230/LIPIcs.CONCUR.2017.5
file:
- access_level: open_access
checksum: d2bda4783821a6358333fe27f11f4737
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:08:02Z
date_updated: 2020-07-14T12:47:49Z
file_id: '4661'
file_name: IST-2017-886-v1+1_LIPIcs-CONCUR-2017-5.pdf
file_size: 570294
relation: main_file
file_date_updated: 2020-07-14T12:47:49Z
has_accepted_license: '1'
intvolume: ' 85'
language:
- iso: eng
month: '08'
oa: 1
oa_version: Published Version
publication_identifier:
issn:
- '18688969'
publication_status: published
publisher: Schloss Dagstuhl - Leibniz-Zentrum für Informatik
publist_id: '6976'
pubrep_id: '886'
quality_controlled: '1'
scopus_import: 1
status: public
title: Bidirectional nested weighted automata
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 85
year: '2017'
...
---
_id: '712'
abstract:
- lang: eng
text: 'We establish a weak–strong uniqueness principle for solutions to entropy-dissipating
reaction–diffusion equations: As long as a strong solution to the reaction–diffusion
equation exists, any weak solution and even any renormalized solution must coincide
with this strong solution. Our assumptions on the reaction rates are just the
entropy condition and local Lipschitz continuity; in particular, we do not impose
any growth restrictions on the reaction rates. Therefore, our result applies to
any single reversible reaction with mass-action kinetics as well as to systems
of reversible reactions with mass-action kinetics satisfying the detailed balance
condition. Renormalized solutions are known to exist globally in time for reaction–diffusion
equations with entropy-dissipating reaction rates; in contrast, the global-in-time
existence of weak solutions is in general still an open problem–even for smooth
data–, thereby motivating the study of renormalized solutions. The key ingredient
of our result is a careful adjustment of the usual relative entropy functional,
whose evolution cannot be controlled properly for weak solutions or renormalized
solutions.'
author:
- first_name: Julian L
full_name: Fischer, Julian L
id: 2C12A0B0-F248-11E8-B48F-1D18A9856A87
last_name: Fischer
orcid: 0000-0002-0479-558X
citation:
ama: 'Fischer JL. Weak–strong uniqueness of solutions to entropy dissipating reaction–diffusion
equations. Nonlinear Analysis: Theory, Methods and Applications. 2017;159:181-207.
doi:10.1016/j.na.2017.03.001'
apa: 'Fischer, J. L. (2017). Weak–strong uniqueness of solutions to entropy dissipating
reaction–diffusion equations. Nonlinear Analysis: Theory, Methods and Applications.
Elsevier. https://doi.org/10.1016/j.na.2017.03.001'
chicago: 'Fischer, Julian L. “Weak–Strong Uniqueness of Solutions to Entropy Dissipating
Reaction–Diffusion Equations.” Nonlinear Analysis: Theory, Methods and Applications.
Elsevier, 2017. https://doi.org/10.1016/j.na.2017.03.001.'
ieee: 'J. L. Fischer, “Weak–strong uniqueness of solutions to entropy dissipating
reaction–diffusion equations,” Nonlinear Analysis: Theory, Methods and Applications,
vol. 159. Elsevier, pp. 181–207, 2017.'
ista: 'Fischer JL. 2017. Weak–strong uniqueness of solutions to entropy dissipating
reaction–diffusion equations. Nonlinear Analysis: Theory, Methods and Applications.
159, 181–207.'
mla: 'Fischer, Julian L. “Weak–Strong Uniqueness of Solutions to Entropy Dissipating
Reaction–Diffusion Equations.” Nonlinear Analysis: Theory, Methods and Applications,
vol. 159, Elsevier, 2017, pp. 181–207, doi:10.1016/j.na.2017.03.001.'
short: 'J.L. Fischer, Nonlinear Analysis: Theory, Methods and Applications 159 (2017)
181–207.'
date_created: 2018-12-11T11:48:05Z
date_published: 2017-08-01T00:00:00Z
date_updated: 2021-01-12T08:11:55Z
day: '01'
department:
- _id: JuFi
doi: 10.1016/j.na.2017.03.001
intvolume: ' 159'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1703.00730
month: '08'
oa: 1
oa_version: Submitted Version
page: 181 - 207
publication: 'Nonlinear Analysis: Theory, Methods and Applications'
publication_identifier:
issn:
- 0362546X
publication_status: published
publisher: Elsevier
publist_id: '6975'
quality_controlled: '1'
scopus_import: 1
status: public
title: Weak–strong uniqueness of solutions to entropy dissipating reaction–diffusion
equations
type: journal_article
user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87
volume: 159
year: '2017'
...
---
_id: '714'
abstract:
- lang: eng
text: Background HIV-1 infection and drug abuse are frequently co-morbid and their
association greatly increases the severity of HIV-1-induced neuropathology. While
nucleus accumbens (NAcc) function is severely perturbed by drugs of abuse, little
is known about how HIV-1 infection affects NAcc. Methods We used calcium and voltage
imaging to investigate the effect of HIV-1 trans-activator of transcription (Tat)
on rat NAcc. Based on previous neuronal studies, we hypothesized that Tat modulates
intracellular Ca2+ homeostasis of NAcc neurons. Results We provide evidence that
Tat triggers a Ca2+ signaling cascade in NAcc medium spiny neurons (MSN) expressing
D1-like dopamine receptors leading to neuronal depolarization. Firstly, Tat induced
inositol 1,4,5-trisphsophate (IP3) receptor-mediated Ca2+ release from endoplasmic
reticulum, followed by Ca2+ and Na+ influx via transient receptor potential canonical
channels. The influx of cations depolarizes the membrane promoting additional
Ca2+ entry through voltage-gated P/Q-type Ca2+ channels and opening of tetrodotoxin-sensitive
Na+ channels. By activating this mechanism, Tat elicits a feed-forward depolarization
increasing the excitability of D1-phosphatidylinositol-linked NAcc MSN. We previously
found that cocaine targets NAcc neurons directly (independent of the inhibition
of dopamine transporter) only when IP3-generating mechanisms are concomitantly
initiated. When tested here, cocaine produced a dose-dependent potentiation of
the effect of Tat on cytosolic Ca2+. Conclusion We describe for the first time
a HIV-1 Tat-triggered Ca2+ signaling in MSN of NAcc involving TRPC and depolarization
and a potentiation of the effect of Tat by cocaine, which may be relevant for
the reward axis in cocaine-abusing HIV-1-positive patients.
acknowledgement: This work was supported by the National Institutes of Health grants
DA035926 (to MEA), and P30DA013429 (to EMU).
article_processing_charge: No
article_type: original
author:
- first_name: Gabriela
full_name: Brailoiu, Gabriela
last_name: Brailoiu
- first_name: Elena
full_name: Deliu, Elena
id: 37A40D7E-F248-11E8-B48F-1D18A9856A87
last_name: Deliu
orcid: 0000-0002-7370-5293
- first_name: Jeffrey
full_name: Barr, Jeffrey
last_name: Barr
- first_name: Linda
full_name: Console Bram, Linda
last_name: Console Bram
- first_name: Alexandra
full_name: Ciuciu, Alexandra
last_name: Ciuciu
- first_name: Mary
full_name: Abood, Mary
last_name: Abood
- first_name: Ellen
full_name: Unterwald, Ellen
last_name: Unterwald
- first_name: Eugen
full_name: Brǎiloiu, Eugen
last_name: Brǎiloiu
citation:
ama: Brailoiu G, Deliu E, Barr J, et al. HIV Tat excites D1 receptor-like expressing
neurons from rat nucleus accumbens. Drug and Alcohol Dependence. 2017;178:7-14.
doi:10.1016/j.drugalcdep.2017.04.015
apa: Brailoiu, G., Deliu, E., Barr, J., Console Bram, L., Ciuciu, A., Abood, M.,
… Brǎiloiu, E. (2017). HIV Tat excites D1 receptor-like expressing neurons from
rat nucleus accumbens. Drug and Alcohol Dependence. Elsevier. https://doi.org/10.1016/j.drugalcdep.2017.04.015
chicago: Brailoiu, Gabriela, Elena Deliu, Jeffrey Barr, Linda Console Bram, Alexandra
Ciuciu, Mary Abood, Ellen Unterwald, and Eugen Brǎiloiu. “HIV Tat Excites D1 Receptor-like
Expressing Neurons from Rat Nucleus Accumbens.” Drug and Alcohol Dependence.
Elsevier, 2017. https://doi.org/10.1016/j.drugalcdep.2017.04.015.
ieee: G. Brailoiu et al., “HIV Tat excites D1 receptor-like expressing neurons
from rat nucleus accumbens,” Drug and Alcohol Dependence, vol. 178. Elsevier,
pp. 7–14, 2017.
ista: Brailoiu G, Deliu E, Barr J, Console Bram L, Ciuciu A, Abood M, Unterwald
E, Brǎiloiu E. 2017. HIV Tat excites D1 receptor-like expressing neurons from
rat nucleus accumbens. Drug and Alcohol Dependence. 178, 7–14.
mla: Brailoiu, Gabriela, et al. “HIV Tat Excites D1 Receptor-like Expressing Neurons
from Rat Nucleus Accumbens.” Drug and Alcohol Dependence, vol. 178, Elsevier,
2017, pp. 7–14, doi:10.1016/j.drugalcdep.2017.04.015.
short: G. Brailoiu, E. Deliu, J. Barr, L. Console Bram, A. Ciuciu, M. Abood, E.
Unterwald, E. Brǎiloiu, Drug and Alcohol Dependence 178 (2017) 7–14.
date_created: 2018-12-11T11:48:05Z
date_published: 2017-09-01T00:00:00Z
date_updated: 2021-01-12T08:12:00Z
day: '01'
department:
- _id: GaNo
doi: 10.1016/j.drugalcdep.2017.04.015
external_id:
pmid:
- '28623807'
intvolume: ' 178'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5797705
month: '09'
oa: 1
oa_version: Submitted Version
page: 7 - 14
pmid: 1
publication: Drug and Alcohol Dependence
publication_identifier:
issn:
- '03768716'
publication_status: published
publisher: Elsevier
publist_id: '6967'
quality_controlled: '1'
scopus_import: 1
status: public
title: HIV Tat excites D1 receptor-like expressing neurons from rat nucleus accumbens
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 178
year: '2017'
...
---
_id: '715'
abstract:
- lang: eng
text: D-cycloserine ameliorates breathing abnormalities and survival rate in a mouse
model of Rett syndrome.
article_number: aao4218
author:
- first_name: Gaia
full_name: Novarino, Gaia
id: 3E57A680-F248-11E8-B48F-1D18A9856A87
last_name: Novarino
orcid: 0000-0002-7673-7178
citation:
ama: Novarino G. More excitation for Rett syndrome. Science Translational Medicine.
2017;9(405). doi:10.1126/scitranslmed.aao4218
apa: Novarino, G. (2017). More excitation for Rett syndrome. Science Translational
Medicine. American Association for the Advancement of Science. https://doi.org/10.1126/scitranslmed.aao4218
chicago: Novarino, Gaia. “More Excitation for Rett Syndrome.” Science Translational
Medicine. American Association for the Advancement of Science, 2017. https://doi.org/10.1126/scitranslmed.aao4218.
ieee: G. Novarino, “More excitation for Rett syndrome,” Science Translational
Medicine, vol. 9, no. 405. American Association for the Advancement of Science,
2017.
ista: Novarino G. 2017. More excitation for Rett syndrome. Science Translational
Medicine. 9(405), aao4218.
mla: Novarino, Gaia. “More Excitation for Rett Syndrome.” Science Translational
Medicine, vol. 9, no. 405, aao4218, American Association for the Advancement
of Science, 2017, doi:10.1126/scitranslmed.aao4218.
short: G. Novarino, Science Translational Medicine 9 (2017).
date_created: 2018-12-11T11:48:06Z
date_published: 2017-08-30T00:00:00Z
date_updated: 2021-01-12T08:12:04Z
day: '30'
department:
- _id: GaNo
doi: 10.1126/scitranslmed.aao4218
intvolume: ' 9'
issue: '405'
language:
- iso: eng
month: '08'
oa_version: None
publication: Science Translational Medicine
publication_identifier:
issn:
- '19466234'
publication_status: published
publisher: American Association for the Advancement of Science
publist_id: '6968'
quality_controlled: '1'
scopus_import: 1
status: public
title: More excitation for Rett syndrome
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 9
year: '2017'
...
---
_id: '716'
abstract:
- lang: eng
text: 'Two-player games on graphs are central in many problems in formal verification
and program analysis, such as synthesis and verification of open systems. In this
work, we consider solving recursive game graphs (or pushdown game graphs) that
model the control flow of sequential programs with recursion.While pushdown games
have been studied before with qualitative objectives-such as reachability and
?-regular objectives- in this work, we study for the first time such games with
the most well-studied quantitative objective, the mean-payoff objective. In pushdown
games, two types of strategies are relevant: (1) global strategies, which depend
on the entire global history; and (2) modular strategies, which have only local
memory and thus do not depend on the context of invocation but rather only on
the history of the current invocation of the module. Our main results are as follows:
(1) One-player pushdown games with mean-payoff objectives under global strategies
are decidable in polynomial time. (2) Two-player pushdown games with mean-payoff
objectives under global strategies are undecidable. (3) One-player pushdown games
with mean-payoff objectives under modular strategies are NP-hard. (4) Two-player
pushdown games with mean-payoff objectives under modular strategies can be solved
in NP (i.e., both one-player and two-player pushdown games with mean-payoff objectives
under modular strategies are NP-complete). We also establish the optimal strategy
complexity by showing that global strategies for mean-payoff objectives require
infinite memory even in one-player pushdown games and memoryless modular strategies
are sufficient in two-player pushdown games. Finally, we also show that all the
problems have the same complexity if the stack boundedness condition is added,
where along with the mean-payoff objective the player must also ensure that the
stack height is bounded.'
article_type: original
author:
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Yaron
full_name: Velner, Yaron
last_name: Velner
citation:
ama: Chatterjee K, Velner Y. The complexity of mean-payoff pushdown games. Journal
of the ACM. 2017;64(5):34. doi:10.1145/3121408
apa: Chatterjee, K., & Velner, Y. (2017). The complexity of mean-payoff pushdown
games. Journal of the ACM. ACM. https://doi.org/10.1145/3121408
chicago: Chatterjee, Krishnendu, and Yaron Velner. “The Complexity of Mean-Payoff
Pushdown Games.” Journal of the ACM. ACM, 2017. https://doi.org/10.1145/3121408.
ieee: K. Chatterjee and Y. Velner, “The complexity of mean-payoff pushdown games,”
Journal of the ACM, vol. 64, no. 5. ACM, p. 34, 2017.
ista: Chatterjee K, Velner Y. 2017. The complexity of mean-payoff pushdown games.
Journal of the ACM. 64(5), 34.
mla: Chatterjee, Krishnendu, and Yaron Velner. “The Complexity of Mean-Payoff Pushdown
Games.” Journal of the ACM, vol. 64, no. 5, ACM, 2017, p. 34, doi:10.1145/3121408.
short: K. Chatterjee, Y. Velner, Journal of the ACM 64 (2017) 34.
date_created: 2018-12-11T11:48:06Z
date_published: 2017-09-01T00:00:00Z
date_updated: 2021-01-12T08:12:08Z
day: '01'
department:
- _id: KrCh
doi: 10.1145/3121408
ec_funded: 1
external_id:
arxiv:
- '1201.2829'
intvolume: ' 64'
issue: '5'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1201.2829
month: '09'
oa: 1
oa_version: Preprint
page: '34'
project:
- _id: 2584A770-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P 23499-N23
name: Modern Graph Algorithmic Techniques in Formal Verification
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
- _id: 2581B60A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '279307'
name: 'Quantitative Graph Games: Theory and Applications'
publication: Journal of the ACM
publication_identifier:
issn:
- '00045411'
publication_status: published
publisher: ACM
publist_id: '6964'
quality_controlled: '1'
scopus_import: 1
status: public
title: The complexity of mean-payoff pushdown games
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 64
year: '2017'
...