---
_id: '403'
abstract:
- lang: eng
text: The ability to adapt growth and development to temperature variations is crucial
to generate plant varieties resilient to predicted temperature changes. However,
the mechanisms underlying plant response to progressive increases in temperature
have just started to be elucidated. Here, we report that the Cyclin-dependent
Kinase G1 (CDKG1) is a central element in a thermo-sensitive mRNA splicing cascade
that transduces changes in ambient temperature into differential expression of
the fundamental spliceosome component, ATU2AF65A. CDKG1 is alternatively spliced
in a temperature-dependent manner. We found that this process is partly dependent
on both the Cyclin-dependent Kinase G2 (CDKG2) and the interacting co-factor CYCLIN
L1 resulting in two distinct messenger RNAs. Relative abundance of both CDKG1
transcripts correlates with ambient temperature and possibly with different expression
levels of the associated protein isoforms. Both CDKG1 alternative transcripts
are necessary to fully complement the expression of ATU2AF65A across the temperature
range. Our data support a previously unidentified temperature-dependent mechanism
based on the alternative splicing of CDKG1 and regulated by CDKG2 and CYCLIN L1.
We propose that changes in ambient temperature affect the relative abundance of
CDKG1 transcripts and this in turn translates into differential CDKG1 protein
expression coordinating the alternative splicing of ATU2AF65A. This article is
protected by copyright. All rights reserved.
acknowledgement: CN, DD and JHD were funded by the BBSRC (grant number BB/M009459/1).
NC was funded by the VIPS Program of the Austrian Federal Ministry of Science and
Research and the City of Vienna. AB and AF were supported by the Austrian Science
Fund (FWF) [DK W1207; SFB RNAreg F43-P10]
article_processing_charge: No
author:
- first_name: Nicola
full_name: Cavallari, Nicola
id: 457160E6-F248-11E8-B48F-1D18A9856A87
last_name: Cavallari
- first_name: Candida
full_name: Nibau, Candida
last_name: Nibau
- first_name: Armin
full_name: Fuchs, Armin
last_name: Fuchs
- first_name: Despoina
full_name: Dadarou, Despoina
last_name: Dadarou
- first_name: Andrea
full_name: Barta, Andrea
last_name: Barta
- first_name: John
full_name: Doonan, John
last_name: Doonan
citation:
ama: Cavallari N, Nibau C, Fuchs A, Dadarou D, Barta A, Doonan J. The cyclin‐dependent
kinase G group defines a thermo‐sensitive alternative splicing circuit modulating
the expression of Arabidopsis ATU 2AF 65A. The Plant Journal. 2018;94(6):1010-1022.
doi:10.1111/tpj.13914
apa: Cavallari, N., Nibau, C., Fuchs, A., Dadarou, D., Barta, A., & Doonan,
J. (2018). The cyclin‐dependent kinase G group defines a thermo‐sensitive alternative
splicing circuit modulating the expression of Arabidopsis ATU 2AF 65A. The
Plant Journal. Wiley. https://doi.org/10.1111/tpj.13914
chicago: Cavallari, Nicola, Candida Nibau, Armin Fuchs, Despoina Dadarou, Andrea
Barta, and John Doonan. “The Cyclin‐dependent Kinase G Group Defines a Thermo‐sensitive
Alternative Splicing Circuit Modulating the Expression of Arabidopsis ATU 2AF
65A.” The Plant Journal. Wiley, 2018. https://doi.org/10.1111/tpj.13914.
ieee: N. Cavallari, C. Nibau, A. Fuchs, D. Dadarou, A. Barta, and J. Doonan, “The
cyclin‐dependent kinase G group defines a thermo‐sensitive alternative splicing
circuit modulating the expression of Arabidopsis ATU 2AF 65A,” The Plant Journal,
vol. 94, no. 6. Wiley, pp. 1010–1022, 2018.
ista: Cavallari N, Nibau C, Fuchs A, Dadarou D, Barta A, Doonan J. 2018. The cyclin‐dependent
kinase G group defines a thermo‐sensitive alternative splicing circuit modulating
the expression of Arabidopsis ATU 2AF 65A. The Plant Journal. 94(6), 1010–1022.
mla: Cavallari, Nicola, et al. “The Cyclin‐dependent Kinase G Group Defines a Thermo‐sensitive
Alternative Splicing Circuit Modulating the Expression of Arabidopsis ATU 2AF
65A.” The Plant Journal, vol. 94, no. 6, Wiley, 2018, pp. 1010–22, doi:10.1111/tpj.13914.
short: N. Cavallari, C. Nibau, A. Fuchs, D. Dadarou, A. Barta, J. Doonan, The Plant
Journal 94 (2018) 1010–1022.
date_created: 2018-12-11T11:46:17Z
date_published: 2018-06-01T00:00:00Z
date_updated: 2023-09-19T10:07:08Z
day: '01'
ddc:
- '580'
department:
- _id: EvBe
doi: 10.1111/tpj.13914
external_id:
isi:
- '000434365500008'
file:
- access_level: open_access
checksum: d9d3ad3215ac0e581731443fca312266
content_type: application/pdf
creator: dernst
date_created: 2019-02-06T11:40:54Z
date_updated: 2020-07-14T12:46:22Z
file_id: '5934'
file_name: 2018_PlantJourn_Cavallari.pdf
file_size: 1543354
relation: main_file
file_date_updated: 2020-07-14T12:46:22Z
has_accepted_license: '1'
intvolume: ' 94'
isi: 1
issue: '6'
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
page: 1010 - 1022
publication: The Plant Journal
publication_status: published
publisher: Wiley
publist_id: '7426'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The cyclin‐dependent kinase G group defines a thermo‐sensitive alternative
splicing circuit modulating the expression of Arabidopsis ATU 2AF 65A
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 94
year: '2018'
...
---
_id: '156'
abstract:
- lang: eng
text: 'Imprecision in timing can sometimes be beneficial: Metric interval temporal
logic (MITL), disabling the expression of punctuality constraints, was shown to
translate to timed automata, yielding an elementary decision procedure. We show
how this principle extends to other forms of dense-time specification using regular
expressions. By providing a clean, automaton-based formal framework for non-punctual
languages, we are able to recover and extend several results in timed systems.
Metric interval regular expressions (MIRE) are introduced, providing regular expressions
with non-singular duration constraints. We obtain that MIRE are expressively complete
relative to a class of one-clock timed automata, which can be determinized using
additional clocks. Metric interval dynamic logic (MIDL) is then defined using
MIRE as temporal modalities. We show that MIDL generalizes known extensions of
MITL, while translating to timed automata at comparable cost.'
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Thomas
full_name: Ferrere, Thomas
id: 40960E6E-F248-11E8-B48F-1D18A9856A87
last_name: Ferrere
orcid: 0000-0001-5199-3143
citation:
ama: 'Ferrere T. The compound interest in relaxing punctuality. In: Vol 10951. Springer;
2018:147-164. doi:10.1007/978-3-319-95582-7_9'
apa: 'Ferrere, T. (2018). The compound interest in relaxing punctuality (Vol. 10951,
pp. 147–164). Presented at the FM: International Symposium on Formal Methods,
Oxford, UK: Springer. https://doi.org/10.1007/978-3-319-95582-7_9'
chicago: Ferrere, Thomas. “The Compound Interest in Relaxing Punctuality,” 10951:147–64.
Springer, 2018. https://doi.org/10.1007/978-3-319-95582-7_9.
ieee: 'T. Ferrere, “The compound interest in relaxing punctuality,” presented at
the FM: International Symposium on Formal Methods, Oxford, UK, 2018, vol. 10951,
pp. 147–164.'
ista: 'Ferrere T. 2018. The compound interest in relaxing punctuality. FM: International
Symposium on Formal Methods, LNCS, vol. 10951, 147–164.'
mla: Ferrere, Thomas. The Compound Interest in Relaxing Punctuality. Vol.
10951, Springer, 2018, pp. 147–64, doi:10.1007/978-3-319-95582-7_9.
short: T. Ferrere, in:, Springer, 2018, pp. 147–164.
conference:
end_date: 2018-07-17
location: Oxford, UK
name: 'FM: International Symposium on Formal Methods'
start_date: 2018-07-15
date_created: 2018-12-11T11:44:55Z
date_published: 2018-07-12T00:00:00Z
date_updated: 2023-09-19T10:05:37Z
day: '12'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-319-95582-7_9
external_id:
isi:
- '000489765800009'
file:
- access_level: open_access
checksum: a045c213c42c445f1889326f8db82a0a
content_type: application/pdf
creator: dernst
date_created: 2020-10-09T06:22:41Z
date_updated: 2020-10-09T06:22:41Z
file_id: '8637'
file_name: 2018_LNCS_Ferrere.pdf
file_size: 485576
relation: main_file
success: 1
file_date_updated: 2020-10-09T06:22:41Z
has_accepted_license: '1'
intvolume: ' 10951'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
page: 147 - 164
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
publication_status: published
publisher: Springer
publist_id: '7765'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The compound interest in relaxing punctuality
type: conference
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 10951
year: '2018'
...
---
_id: '40'
abstract:
- lang: eng
text: Hanemaaijer et al. (Molecular Ecology, 27, 2018) describe the genetic consequences
of the introgression of an insecticide resistance allele into a mosquito population.
Linked alleles initially increased, but many of these later declined. It is hard
to determine whether this decline was due to counter‐selection, rather than simply
to chance.
article_processing_charge: Yes (via OA deal)
article_type: letter_note
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. The consequences of an introgression event. Molecular Ecology.
2018;27(24):4973-4975. doi:10.1111/mec.14950
apa: Barton, N. H. (2018). The consequences of an introgression event. Molecular
Ecology. Wiley. https://doi.org/10.1111/mec.14950
chicago: Barton, Nicholas H. “The Consequences of an Introgression Event.” Molecular
Ecology. Wiley, 2018. https://doi.org/10.1111/mec.14950.
ieee: N. H. Barton, “The consequences of an introgression event,” Molecular Ecology,
vol. 27, no. 24. Wiley, pp. 4973–4975, 2018.
ista: Barton NH. 2018. The consequences of an introgression event. Molecular Ecology.
27(24), 4973–4975.
mla: Barton, Nicholas H. “The Consequences of an Introgression Event.” Molecular
Ecology, vol. 27, no. 24, Wiley, 2018, pp. 4973–75, doi:10.1111/mec.14950.
short: N.H. Barton, Molecular Ecology 27 (2018) 4973–4975.
date_created: 2018-12-11T11:44:18Z
date_published: 2018-12-31T00:00:00Z
date_updated: 2023-09-19T10:06:08Z
day: '31'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1111/mec.14950
external_id:
isi:
- '000454600500001'
pmid:
- '30599087'
file:
- access_level: open_access
content_type: application/pdf
creator: apreinsp
date_created: 2019-07-19T06:54:46Z
date_updated: 2020-07-14T12:46:22Z
file_id: '6652'
file_name: 2018_MolecularEcology_BartonNick.pdf
file_size: 295452
relation: main_file
file_date_updated: 2020-07-14T12:46:22Z
has_accepted_license: '1'
intvolume: ' 27'
isi: 1
issue: '24'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 4973-4975
pmid: 1
publication: Molecular Ecology
publication_identifier:
issn:
- 1365294X
publication_status: published
publisher: Wiley
publist_id: '8014'
quality_controlled: '1'
related_material:
record:
- id: '9805'
relation: research_data
status: public
scopus_import: '1'
status: public
title: The consequences of an introgression event
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 27
year: '2018'
...
---
_id: '5861'
abstract:
- lang: eng
text: In zebrafish larvae, it is the cell type that determines how the cell responds
to a chemokine signal.
article_number: e37888
article_processing_charge: No
article_type: original
author:
- first_name: Jonna H
full_name: Alanko, Jonna H
id: 2CC12E8C-F248-11E8-B48F-1D18A9856A87
last_name: Alanko
orcid: 0000-0002-7698-3061
- first_name: Michael K
full_name: Sixt, Michael K
id: 41E9FBEA-F248-11E8-B48F-1D18A9856A87
last_name: Sixt
orcid: 0000-0002-6620-9179
citation:
ama: Alanko JH, Sixt MK. The cell sets the tone. eLife. 2018;7. doi:10.7554/eLife.37888
apa: Alanko, J. H., & Sixt, M. K. (2018). The cell sets the tone. ELife.
eLife Sciences Publications. https://doi.org/10.7554/eLife.37888
chicago: Alanko, Jonna H, and Michael K Sixt. “The Cell Sets the Tone.” ELife.
eLife Sciences Publications, 2018. https://doi.org/10.7554/eLife.37888.
ieee: J. H. Alanko and M. K. Sixt, “The cell sets the tone,” eLife, vol.
7. eLife Sciences Publications, 2018.
ista: Alanko JH, Sixt MK. 2018. The cell sets the tone. eLife. 7, e37888.
mla: Alanko, Jonna H., and Michael K. Sixt. “The Cell Sets the Tone.” ELife,
vol. 7, e37888, eLife Sciences Publications, 2018, doi:10.7554/eLife.37888.
short: J.H. Alanko, M.K. Sixt, ELife 7 (2018).
date_created: 2019-01-20T22:59:19Z
date_published: 2018-06-06T00:00:00Z
date_updated: 2023-09-19T10:01:39Z
day: '06'
ddc:
- '570'
department:
- _id: MiSi
doi: 10.7554/eLife.37888
external_id:
isi:
- '000434375000001'
file:
- access_level: open_access
checksum: f1c7ec2a809408d763c4b529a98f9a3b
content_type: application/pdf
creator: dernst
date_created: 2019-02-13T10:52:11Z
date_updated: 2020-07-14T12:47:13Z
file_id: '5973'
file_name: 2018_eLife_Alanko.pdf
file_size: 358141
relation: main_file
file_date_updated: 2020-07-14T12:47:13Z
has_accepted_license: '1'
intvolume: ' 7'
isi: 1
language:
- iso: eng
month: '06'
oa: 1
oa_version: Published Version
publication: eLife
publication_identifier:
issn:
- 2050084X
publication_status: published
publisher: eLife Sciences Publications
quality_controlled: '1'
scopus_import: '1'
status: public
title: The cell sets the tone
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 7
year: '2018'
...
---
_id: '147'
abstract:
- lang: eng
text: The trafficking of subcellular cargos in eukaryotic cells crucially depends
on vesicle budding, a process mediated by ARF-GEFs (ADP-ribosylation factor guanine
nucleotide exchange factors). In plants, ARF-GEFs play essential roles in endocytosis,
vacuolar trafficking, recycling, secretion, and polar trafficking. Moreover, they
are important for plant development, mainly through controlling the polar subcellular
localization of PIN-FORMED (PIN) transporters of the plant hormone auxin. Here,
using a chemical genetics screen in Arabidopsis thaliana, we identified Endosidin
4 (ES4), an inhibitor of eukaryotic ARF-GEFs. ES4 acts similarly to and synergistically
with the established ARF-GEF inhibitor Brefeldin A and has broad effects on intracellular
trafficking, including endocytosis, exocytosis, and vacuolar targeting. Additionally,
Arabidopsis and yeast (Sacharomyces cerevisiae) mutants defective in ARF-GEF show
altered sensitivity to ES4. ES4 interferes with the activation-based membrane
association of the ARF1 GTPases, but not of their mutant variants that are activated
independently of ARF-GEF activity. Biochemical approaches and docking simulations
confirmed that ES4 specifically targets the SEC7 domain-containing ARF-GEFs. These
observations collectively identify ES4 as a chemical tool enabling the study of
ARF-GEF-mediated processes, including ARF-GEF-mediated plant development.
acknowledgement: We thank Gerd Jürgens, Sandra Richter, and Sheng Yang He for providing
antibodies; Maciek Adamowski, Fernando Aniento, Sebastian Bednarek, Nico Callewaert,
Matyás Fendrych, Elena Feraru, and Mugurel I. Feraru for helpful suggestions; Siamsa
Doyle for critical reading of the manuscript and helpful comments and suggestions;
and Stephanie Smith and Martine De Cock for help in editing and language corrections.
We acknowledge the core facility Cellular Imaging of CEITEC supported by the Czech-BioImaging
large RI project (LM2015062 funded by MEYS CR) for their support with obtaining
scientific data presented in this article. Plant Sciences Core Facility of CEITEC
Masaryk University is gratefully acknowledged for obtaining part of the scientific
data presented in this article. We acknowledge support from the Fondation pour la
Recherche Médicale and from the Institut National du Cancer (J.C.). The research
leading to these results was funded by the European Research Council under the European
Union's 7th Framework Program (FP7/2007-2013)/ERC grant agreement numbers 282300
and 742985 and the Czech Science Foundation GAČR (GA18-26981S; J.F.); Ministry of
Education, Youth, and Sports/MEYS of the Czech Republic under the Project CEITEC
2020 (LQ1601; T.N.); the China Science Council for a predoctoral fellowship (Q.L.);
a joint research project within the framework of cooperation between the Research
Foundation-Flanders and the Bulgarian Academy of Sciences (VS.025.13N; K.M. and
E.R.); Vetenskapsrådet and Vinnova (Verket för Innovationssystem; S.R.), Knut och
Alice Wallenbergs Stiftelse via “Shapesystem” Grant 2012.0050 (S.R.), Kempe stiftelserna
(P.G.), Tryggers CTS410 (P.G.).
article_processing_charge: No
article_type: original
author:
- first_name: Urszula
full_name: Kania, Urszula
id: 4AE5C486-F248-11E8-B48F-1D18A9856A87
last_name: Kania
- first_name: Tomasz
full_name: Nodzyński, Tomasz
last_name: Nodzyński
- first_name: Qing
full_name: Lu, Qing
last_name: Lu
- first_name: Glenn R
full_name: Hicks, Glenn R
last_name: Hicks
- first_name: Wim
full_name: Nerinckx, Wim
last_name: Nerinckx
- first_name: Kiril
full_name: Mishev, Kiril
last_name: Mishev
- first_name: Francois
full_name: Peurois, Francois
last_name: Peurois
- first_name: Jacqueline
full_name: Cherfils, Jacqueline
last_name: Cherfils
- first_name: Rycke Riet Maria
full_name: De, Rycke Riet Maria
last_name: De
- first_name: Peter
full_name: Grones, Peter
id: 399876EC-F248-11E8-B48F-1D18A9856A87
last_name: Grones
- first_name: Stéphanie
full_name: Robert, Stéphanie
last_name: Robert
- first_name: Eugenia
full_name: Russinova, Eugenia
last_name: Russinova
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Kania U, Nodzyński T, Lu Q, et al. The inhibitor Endosidin 4 targets SEC7 domain-type
ARF GTPase exchange factors and interferes with sub cellular trafficking in eukaryotes.
The Plant Cell. 2018;30(10):2553-2572. doi:10.1105/tpc.18.00127
apa: Kania, U., Nodzyński, T., Lu, Q., Hicks, G. R., Nerinckx, W., Mishev, K., …
Friml, J. (2018). The inhibitor Endosidin 4 targets SEC7 domain-type ARF GTPase
exchange factors and interferes with sub cellular trafficking in eukaryotes. The
Plant Cell. Oxford University Press. https://doi.org/10.1105/tpc.18.00127
chicago: Kania, Urszula, Tomasz Nodzyński, Qing Lu, Glenn R Hicks, Wim Nerinckx,
Kiril Mishev, Francois Peurois, et al. “The Inhibitor Endosidin 4 Targets SEC7
Domain-Type ARF GTPase Exchange Factors and Interferes with Sub Cellular Trafficking
in Eukaryotes.” The Plant Cell. Oxford University Press, 2018. https://doi.org/10.1105/tpc.18.00127.
ieee: U. Kania et al., “The inhibitor Endosidin 4 targets SEC7 domain-type
ARF GTPase exchange factors and interferes with sub cellular trafficking in eukaryotes,”
The Plant Cell, vol. 30, no. 10. Oxford University Press, pp. 2553–2572,
2018.
ista: Kania U, Nodzyński T, Lu Q, Hicks GR, Nerinckx W, Mishev K, Peurois F, Cherfils
J, De RRM, Grones P, Robert S, Russinova E, Friml J. 2018. The inhibitor Endosidin
4 targets SEC7 domain-type ARF GTPase exchange factors and interferes with sub
cellular trafficking in eukaryotes. The Plant Cell. 30(10), 2553–2572.
mla: Kania, Urszula, et al. “The Inhibitor Endosidin 4 Targets SEC7 Domain-Type
ARF GTPase Exchange Factors and Interferes with Sub Cellular Trafficking in Eukaryotes.”
The Plant Cell, vol. 30, no. 10, Oxford University Press, 2018, pp. 2553–72,
doi:10.1105/tpc.18.00127.
short: U. Kania, T. Nodzyński, Q. Lu, G.R. Hicks, W. Nerinckx, K. Mishev, F. Peurois,
J. Cherfils, R.R.M. De, P. Grones, S. Robert, E. Russinova, J. Friml, The Plant
Cell 30 (2018) 2553–2572.
date_created: 2018-12-11T11:44:52Z
date_published: 2018-11-12T00:00:00Z
date_updated: 2023-09-19T10:09:12Z
day: '12'
department:
- _id: JiFr
doi: 10.1105/tpc.18.00127
ec_funded: 1
external_id:
isi:
- '000450000500023'
pmid:
- '30018156'
intvolume: ' 30'
isi: 1
issue: '10'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1105/tpc.18.00127
month: '11'
oa: 1
oa_version: Published Version
page: 2553 - 2572
pmid: 1
project:
- _id: 25716A02-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '282300'
name: Polarity and subcellular dynamics in plants
- _id: 261099A6-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '742985'
name: Tracing Evolution of Auxin Transport and Polarity in Plants
publication: The Plant Cell
publication_identifier:
issn:
- 1040-4651
publication_status: published
publisher: Oxford University Press
publist_id: '7776'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The inhibitor Endosidin 4 targets SEC7 domain-type ARF GTPase exchange factors
and interferes with sub cellular trafficking in eukaryotes
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 30
year: '2018'
...
---
_id: '146'
abstract:
- lang: eng
text: The root cap protects the stem cell niche of angiosperm roots from damage.
In Arabidopsis, lateral root cap (LRC) cells covering the meristematic zone are
regularly lost through programmed cell death, while the outermost layer of the
root cap covering the tip is repeatedly sloughed. Efficient coordination with
stem cells producing new layers is needed to maintain a constant size of the cap.
We present a signalling pair, the peptide IDA-LIKE1 (IDL1) and its receptor HAESA-LIKE2
(HSL2), mediating such communication. Live imaging over several days characterized
this process from initial fractures in LRC cell files to full separation of a
layer. Enhanced expression of IDL1 in the separating root cap layers resulted
in increased frequency of sloughing, balanced with generation of new layers in
a HSL2-dependent manner. Transcriptome analyses linked IDL1-HSL2 signalling to
the transcription factors BEARSKIN1/2 and genes associated with programmed cell
death. Mutations in either IDL1 or HSL2 slowed down cell division, maturation
and separation. Thus, IDL1-HSL2 signalling potentiates dynamic regulation of the
homeostatic balance between stem cell division and sloughing activity.
article_processing_charge: No
article_type: original
author:
- first_name: Chun Lin
full_name: Shi, Chun Lin
last_name: Shi
- first_name: Daniel
full_name: Von Wangenheim, Daniel
id: 49E91952-F248-11E8-B48F-1D18A9856A87
last_name: Von Wangenheim
orcid: 0000-0002-6862-1247
- first_name: Ullrich
full_name: Herrmann, Ullrich
last_name: Herrmann
- first_name: Mari
full_name: Wildhagen, Mari
last_name: Wildhagen
- first_name: Ivan
full_name: Kulik, Ivan
id: F0AB3FCE-02D1-11E9-BD0E-99399A5D3DEB
last_name: Kulik
- first_name: Andreas
full_name: Kopf, Andreas
last_name: Kopf
- first_name: Takashi
full_name: Ishida, Takashi
last_name: Ishida
- first_name: Vilde
full_name: Olsson, Vilde
last_name: Olsson
- first_name: Mari Kristine
full_name: Anker, Mari Kristine
last_name: Anker
- first_name: Markus
full_name: Albert, Markus
last_name: Albert
- first_name: Melinka A
full_name: Butenko, Melinka A
last_name: Butenko
- first_name: Georg
full_name: Felix, Georg
last_name: Felix
- first_name: Shinichiro
full_name: Sawa, Shinichiro
last_name: Sawa
- first_name: Manfred
full_name: Claassen, Manfred
last_name: Claassen
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Reidunn B
full_name: Aalen, Reidunn B
last_name: Aalen
citation:
ama: Shi CL, von Wangenheim D, Herrmann U, et al. The dynamics of root cap sloughing
in Arabidopsis is regulated by peptide signalling. Nature Plants. 2018;4(8):596-604.
doi:10.1038/s41477-018-0212-z
apa: Shi, C. L., von Wangenheim, D., Herrmann, U., Wildhagen, M., Kulik, I., Kopf,
A., … Aalen, R. B. (2018). The dynamics of root cap sloughing in Arabidopsis is
regulated by peptide signalling. Nature Plants. Nature Publishing Group.
https://doi.org/10.1038/s41477-018-0212-z
chicago: Shi, Chun Lin, Daniel von Wangenheim, Ullrich Herrmann, Mari Wildhagen,
Ivan Kulik, Andreas Kopf, Takashi Ishida, et al. “The Dynamics of Root Cap Sloughing
in Arabidopsis Is Regulated by Peptide Signalling.” Nature Plants. Nature
Publishing Group, 2018. https://doi.org/10.1038/s41477-018-0212-z.
ieee: C. L. Shi et al., “The dynamics of root cap sloughing in Arabidopsis
is regulated by peptide signalling,” Nature Plants, vol. 4, no. 8. Nature
Publishing Group, pp. 596–604, 2018.
ista: Shi CL, von Wangenheim D, Herrmann U, Wildhagen M, Kulik I, Kopf A, Ishida
T, Olsson V, Anker MK, Albert M, Butenko MA, Felix G, Sawa S, Claassen M, Friml
J, Aalen RB. 2018. The dynamics of root cap sloughing in Arabidopsis is regulated
by peptide signalling. Nature Plants. 4(8), 596–604.
mla: Shi, Chun Lin, et al. “The Dynamics of Root Cap Sloughing in Arabidopsis Is
Regulated by Peptide Signalling.” Nature Plants, vol. 4, no. 8, Nature
Publishing Group, 2018, pp. 596–604, doi:10.1038/s41477-018-0212-z.
short: C.L. Shi, D. von Wangenheim, U. Herrmann, M. Wildhagen, I. Kulik, A. Kopf,
T. Ishida, V. Olsson, M.K. Anker, M. Albert, M.A. Butenko, G. Felix, S. Sawa,
M. Claassen, J. Friml, R.B. Aalen, Nature Plants 4 (2018) 596–604.
date_created: 2018-12-11T11:44:52Z
date_published: 2018-07-30T00:00:00Z
date_updated: 2023-09-19T10:08:45Z
day: '30'
ddc:
- '580'
department:
- _id: JiFr
doi: 10.1038/s41477-018-0212-z
external_id:
isi:
- '000443861300016'
pmid:
- '30061750'
file:
- access_level: open_access
checksum: da33101c76ee1b2dc5ab28fd2ccba9d0
content_type: application/pdf
creator: dernst
date_created: 2019-11-18T16:24:07Z
date_updated: 2020-07-14T12:44:56Z
file_id: '7043'
file_name: 2018_NaturePlants_Shi.pdf
file_size: 226829
relation: main_file
file_date_updated: 2020-07-14T12:44:56Z
has_accepted_license: '1'
intvolume: ' 4'
isi: 1
issue: '8'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
page: 596 - 604
pmid: 1
publication: Nature Plants
publication_status: published
publisher: Nature Publishing Group
publist_id: '7777'
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/new-process-in-root-development-discovered/
scopus_import: '1'
status: public
title: The dynamics of root cap sloughing in Arabidopsis is regulated by peptide signalling
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 4
year: '2018'
...
---
_id: '293'
abstract:
- lang: eng
text: People sometimes make their admirable deeds and accomplishments hard to spot,
such as by giving anonymously or avoiding bragging. Such ‘buried’ signals are
hard to reconcile with standard models of signalling or indirect reciprocity,
which motivate costly pro-social behaviour by reputational gains. To explain these
phenomena, we design a simple game theory model, which we call the signal-burying
game. This game has the feature that senders can bury their signal by deliberately
reducing the probability of the signal being observed. If the signal is observed,
however, it is identified as having been buried. We show under which conditions
buried signals can be maintained, using static equilibrium concepts and calculations
of the evolutionary dynamics. We apply our analysis to shed light on a number
of otherwise puzzling social phenomena, including modesty, anonymous donations,
subtlety in art and fashion, and overeagerness.
acknowledgement: This work was supported by a grant from the John Templeton Foundation
and by the Office of Naval Research Grant N00014-16-1-2914 (M.A.N.). C.H. acknowledges
generous support from the ISTFELLOW programme and by the Schrödinger scholarship
of the Austrian Science Fund (FWF) J3475.
article_processing_charge: No
article_type: original
author:
- first_name: Moshe
full_name: Hoffman, Moshe
last_name: Hoffman
- first_name: Christian
full_name: Hilbe, Christian
id: 2FDF8F3C-F248-11E8-B48F-1D18A9856A87
last_name: Hilbe
orcid: 0000-0001-5116-955X
- first_name: Martin
full_name: Nowak, Martin
last_name: Nowak
citation:
ama: Hoffman M, Hilbe C, Nowak M. The signal-burying game can explain why we obscure
positive traits and good deeds. Nature Human Behaviour. 2018;2:397-404.
doi:10.1038/s41562-018-0354-z
apa: Hoffman, M., Hilbe, C., & Nowak, M. (2018). The signal-burying game can
explain why we obscure positive traits and good deeds. Nature Human Behaviour.
Nature Publishing Group. https://doi.org/10.1038/s41562-018-0354-z
chicago: Hoffman, Moshe, Christian Hilbe, and Martin Nowak. “The Signal-Burying
Game Can Explain Why We Obscure Positive Traits and Good Deeds.” Nature Human
Behaviour. Nature Publishing Group, 2018. https://doi.org/10.1038/s41562-018-0354-z.
ieee: M. Hoffman, C. Hilbe, and M. Nowak, “The signal-burying game can explain why
we obscure positive traits and good deeds,” Nature Human Behaviour, vol.
2. Nature Publishing Group, pp. 397–404, 2018.
ista: Hoffman M, Hilbe C, Nowak M. 2018. The signal-burying game can explain why
we obscure positive traits and good deeds. Nature Human Behaviour. 2, 397–404.
mla: Hoffman, Moshe, et al. “The Signal-Burying Game Can Explain Why We Obscure
Positive Traits and Good Deeds.” Nature Human Behaviour, vol. 2, Nature
Publishing Group, 2018, pp. 397–404, doi:10.1038/s41562-018-0354-z.
short: M. Hoffman, C. Hilbe, M. Nowak, Nature Human Behaviour 2 (2018) 397–404.
date_created: 2018-12-11T11:45:39Z
date_published: 2018-05-28T00:00:00Z
date_updated: 2023-09-19T10:12:03Z
day: '28'
ddc:
- '000'
department:
- _id: KrCh
doi: 10.1038/s41562-018-0354-z
ec_funded: 1
external_id:
isi:
- '000435551300009'
file:
- access_level: open_access
checksum: 32efaf06a597495c184df91b3fbb19c0
content_type: application/pdf
creator: dernst
date_created: 2019-11-19T08:17:23Z
date_updated: 2020-07-14T12:45:54Z
file_id: '7051'
file_name: 2018_NatureHumanBeh_Hoffman.pdf
file_size: 194734
relation: main_file
file_date_updated: 2020-07-14T12:45:54Z
has_accepted_license: '1'
intvolume: ' 2'
isi: 1
language:
- iso: eng
month: '05'
oa: 1
oa_version: Submitted Version
page: 397 - 404
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Nature Human Behaviour
publication_status: published
publisher: Nature Publishing Group
publist_id: '7588'
quality_controlled: '1'
related_material:
link:
- description: News on IST Homepage
relation: press_release
url: https://ist.ac.at/en/news/the-logic-of-modesty-why-it-pays-to-be-humble/
scopus_import: '1'
status: public
title: The signal-burying game can explain why we obscure positive traits and good
deeds
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 2
year: '2018'
...
---
_id: '455'
abstract:
- lang: eng
text: The derivation of effective evolution equations is central to the study of
non-stationary quantum many-body systems, and widely used in contexts such as
superconductivity, nuclear physics, Bose–Einstein condensation and quantum chemistry.
We reformulate the Dirac–Frenkel approximation principle in terms of reduced density
matrices and apply it to fermionic and bosonic many-body systems. We obtain the
Bogoliubov–de Gennes and Hartree–Fock–Bogoliubov equations, respectively. While
we do not prove quantitative error estimates, our formulation does show that the
approximation is optimal within the class of quasifree states. Furthermore, we
prove well-posedness of the Bogoliubov–de Gennes equations in energy space and
discuss conserved quantities
acknowledgement: Open access funding provided by Institute of Science and Technology
(IST Austria). The authors acknowledge support by ERC Advanced Grant 321029 and
by VILLUM FONDEN via the QMATH Centre of Excellence (Grant No. 10059). The authors
would like to thank Sébastien Breteaux, Enno Lenzmann, Mathieu Lewin and Jochen
Schmid for comments and discussions about well-posedness of the Bogoliubov–de Gennes
equations.
alternative_title:
- Annales Henri Poincare
article_processing_charge: No
author:
- first_name: Niels P
full_name: Benedikter, Niels P
id: 3DE6C32A-F248-11E8-B48F-1D18A9856A87
last_name: Benedikter
orcid: 0000-0002-1071-6091
- first_name: Jérémy
full_name: Sok, Jérémy
last_name: Sok
- first_name: Jan
full_name: Solovej, Jan
last_name: Solovej
citation:
ama: Benedikter NP, Sok J, Solovej J. The Dirac–Frenkel principle for reduced density
matrices and the Bogoliubov–de Gennes equations. Annales Henri Poincare.
2018;19(4):1167-1214. doi:10.1007/s00023-018-0644-z
apa: Benedikter, N. P., Sok, J., & Solovej, J. (2018). The Dirac–Frenkel principle
for reduced density matrices and the Bogoliubov–de Gennes equations. Annales
Henri Poincare. Birkhäuser. https://doi.org/10.1007/s00023-018-0644-z
chicago: Benedikter, Niels P, Jérémy Sok, and Jan Solovej. “The Dirac–Frenkel Principle
for Reduced Density Matrices and the Bogoliubov–de Gennes Equations.” Annales
Henri Poincare. Birkhäuser, 2018. https://doi.org/10.1007/s00023-018-0644-z.
ieee: N. P. Benedikter, J. Sok, and J. Solovej, “The Dirac–Frenkel principle for
reduced density matrices and the Bogoliubov–de Gennes equations,” Annales Henri
Poincare, vol. 19, no. 4. Birkhäuser, pp. 1167–1214, 2018.
ista: Benedikter NP, Sok J, Solovej J. 2018. The Dirac–Frenkel principle for reduced
density matrices and the Bogoliubov–de Gennes equations. Annales Henri Poincare.
19(4), 1167–1214.
mla: Benedikter, Niels P., et al. “The Dirac–Frenkel Principle for Reduced Density
Matrices and the Bogoliubov–de Gennes Equations.” Annales Henri Poincare,
vol. 19, no. 4, Birkhäuser, 2018, pp. 1167–214, doi:10.1007/s00023-018-0644-z.
short: N.P. Benedikter, J. Sok, J. Solovej, Annales Henri Poincare 19 (2018) 1167–1214.
date_created: 2018-12-11T11:46:34Z
date_published: 2018-04-01T00:00:00Z
date_updated: 2023-09-19T10:07:41Z
day: '01'
ddc:
- '510'
- '539'
department:
- _id: RoSe
doi: 10.1007/s00023-018-0644-z
external_id:
isi:
- '000427578900006'
file:
- access_level: open_access
checksum: 883eeccba8384ad7fcaa28761d99a0fa
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:11:57Z
date_updated: 2020-07-14T12:46:31Z
file_id: '4914'
file_name: IST-2018-993-v1+1_2018_Benedikter_Dirac.pdf
file_size: 923252
relation: main_file
file_date_updated: 2020-07-14T12:46:31Z
has_accepted_license: '1'
intvolume: ' 19'
isi: 1
issue: '4'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 1167 - 1214
publication: Annales Henri Poincare
publication_status: published
publisher: Birkhäuser
publist_id: '7367'
pubrep_id: '993'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The Dirac–Frenkel principle for reduced density matrices and the Bogoliubov–de
Gennes equations
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 19
year: '2018'
...
---
_id: '314'
abstract:
- lang: eng
text: The interface of physics and biology pro-vides a fruitful environment for
generatingnew concepts and exciting ways forwardto understanding living matter.
Examplesof successful studies include the estab-lishment and readout of morphogen
gra-dients during development, signal pro-cessing in protein and genetic networks,the
role of fluctuations in determining thefates of cells and tissues, and collectiveeffects
in proteins and in tissues. It is nothard to envision that significant further
ad-vances will translate to societal benefitsby initiating the development of new
de-vices and strategies for curing disease.However, research at the interface
posesvarious challenges, in particular for youngscientists, and current institutions
arerarely designed to facilitate such scientificprograms. In this Letter, we propose
aninternational initiative that addressesthese challenges through the establish-ment
of a worldwide network of platformsfor cross-disciplinary training and incuba-tors
for starting new collaborations.
article_processing_charge: No
article_type: letter_note
author:
- first_name: Guntram
full_name: Bauer, Guntram
last_name: Bauer
- first_name: Nikta
full_name: Fakhri, Nikta
last_name: Fakhri
- first_name: Anna
full_name: Kicheva, Anna
id: 3959A2A0-F248-11E8-B48F-1D18A9856A87
last_name: Kicheva
orcid: 0000-0003-4509-4998
- first_name: Jané
full_name: Kondev, Jané
last_name: Kondev
- first_name: Karsten
full_name: Kruse, Karsten
last_name: Kruse
- first_name: Hiroyuki
full_name: Noji, Hiroyuki
last_name: Noji
- first_name: Daniel
full_name: Riveline, Daniel
last_name: Riveline
- first_name: Timothy
full_name: Saunders, Timothy
last_name: Saunders
- first_name: Mukund
full_name: Thatta, Mukund
last_name: Thatta
- first_name: Eric
full_name: Wieschaus, Eric
last_name: Wieschaus
citation:
ama: Bauer G, Fakhri N, Kicheva A, et al. The science of living matter for tomorrow.
Cell Systems. 2018;6(4):400-402. doi:10.1016/j.cels.2018.04.003
apa: Bauer, G., Fakhri, N., Kicheva, A., Kondev, J., Kruse, K., Noji, H., … Wieschaus,
E. (2018). The science of living matter for tomorrow. Cell Systems. Cell
Press. https://doi.org/10.1016/j.cels.2018.04.003
chicago: Bauer, Guntram, Nikta Fakhri, Anna Kicheva, Jané Kondev, Karsten Kruse,
Hiroyuki Noji, Daniel Riveline, Timothy Saunders, Mukund Thatta, and Eric Wieschaus.
“The Science of Living Matter for Tomorrow.” Cell Systems. Cell Press,
2018. https://doi.org/10.1016/j.cels.2018.04.003.
ieee: G. Bauer et al., “The science of living matter for tomorrow,” Cell
Systems, vol. 6, no. 4. Cell Press, pp. 400–402, 2018.
ista: Bauer G, Fakhri N, Kicheva A, Kondev J, Kruse K, Noji H, Riveline D, Saunders
T, Thatta M, Wieschaus E. 2018. The science of living matter for tomorrow. Cell
Systems. 6(4), 400–402.
mla: Bauer, Guntram, et al. “The Science of Living Matter for Tomorrow.” Cell
Systems, vol. 6, no. 4, Cell Press, 2018, pp. 400–02, doi:10.1016/j.cels.2018.04.003.
short: G. Bauer, N. Fakhri, A. Kicheva, J. Kondev, K. Kruse, H. Noji, D. Riveline,
T. Saunders, M. Thatta, E. Wieschaus, Cell Systems 6 (2018) 400–402.
date_created: 2018-12-11T11:45:46Z
date_published: 2018-04-25T00:00:00Z
date_updated: 2023-09-19T10:11:25Z
day: '25'
department:
- _id: AnKi
doi: 10.1016/j.cels.2018.04.003
external_id:
isi:
- '000432192100003'
pmid:
- '29698645'
intvolume: ' 6'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1016/j.cels.2018.04.003
month: '04'
oa: 1
oa_version: Published Version
page: 400 - 402
pmid: 1
publication: Cell Systems
publication_identifier:
eissn:
- 2405-4712
publication_status: published
publisher: Cell Press
publist_id: '7551'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The science of living matter for tomorrow
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 6
year: '2018'
...
---
_id: '565'
abstract:
- lang: eng
text: 'We re-examine the model of Kirkpatrick and Barton for the spread of an inversion
into a local population. This model assumes that local selection maintains alleles
at two or more loci, despite immigration of alternative alleles at these loci
from another population. We show that an inversion is favored because it prevents
the breakdown of linkage disequilibrium generated by migration; the selective
advantage of an inversion is proportional to the amount of recombination between
the loci involved, as in other cases where inversions are selected for. We derive
expressions for the rate of spread of an inversion; when the loci covered by the
inversion are tightly linked, these conditions deviate substantially from those
proposed previously, and imply that an inversion can then have only a small advantage. '
article_processing_charge: No
article_type: original
author:
- first_name: Brian
full_name: Charlesworth, Brian
last_name: Charlesworth
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Charlesworth B, Barton NH. The spread of an inversion with migration and selection.
Genetics. 2018;208(1):377-382. doi:10.1534/genetics.117.300426
apa: Charlesworth, B., & Barton, N. H. (2018). The spread of an inversion with
migration and selection. Genetics. Genetics . https://doi.org/10.1534/genetics.117.300426
chicago: Charlesworth, Brian, and Nicholas H Barton. “The Spread of an Inversion
with Migration and Selection.” Genetics. Genetics , 2018. https://doi.org/10.1534/genetics.117.300426.
ieee: B. Charlesworth and N. H. Barton, “The spread of an inversion with migration
and selection,” Genetics, vol. 208, no. 1. Genetics , pp. 377–382, 2018.
ista: Charlesworth B, Barton NH. 2018. The spread of an inversion with migration
and selection. Genetics. 208(1), 377–382.
mla: Charlesworth, Brian, and Nicholas H. Barton. “The Spread of an Inversion with
Migration and Selection.” Genetics, vol. 208, no. 1, Genetics , 2018, pp.
377–82, doi:10.1534/genetics.117.300426.
short: B. Charlesworth, N.H. Barton, Genetics 208 (2018) 377–382.
date_created: 2018-12-11T11:47:12Z
date_published: 2018-01-01T00:00:00Z
date_updated: 2023-09-19T10:12:31Z
day: '01'
department:
- _id: NiBa
doi: 10.1534/genetics.117.300426
external_id:
isi:
- '000419356300025'
pmid:
- '29158424'
intvolume: ' 208'
isi: 1
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5753870/
month: '01'
oa: 1
oa_version: Published Version
page: 377 - 382
pmid: 1
publication: Genetics
publication_status: published
publisher: 'Genetics '
publist_id: '7249'
quality_controlled: '1'
scopus_import: '1'
status: public
title: The spread of an inversion with migration and selection
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 208
year: '2018'
...