[{"scopus_import":"1","day":"30","article_processing_charge":"No","has_accepted_license":"1","publication":"PLoS Biology","citation":{"chicago":"Schmidt, Tom, Nicholas H Barton, Gordana Rasic, Andrew Turley, Brian Montgomery, Inaki Iturbe Ormaetxe, Peter Cook, et al. “Local Introduction and Heterogeneous Spatial Spread of Dengue-Suppressing Wolbachia through an Urban Population of Aedes Aegypti.” PLoS Biology. Public Library of Science, 2017. https://doi.org/10.1371/journal.pbio.2001894.","short":"T. Schmidt, N.H. Barton, G. Rasic, A. Turley, B. Montgomery, I. Iturbe Ormaetxe, P. Cook, P. Ryan, S. Ritchie, A. Hoffmann, S. O’Neill, M. Turelli, PLoS Biology 15 (2017).","mla":"Schmidt, Tom, et al. “Local Introduction and Heterogeneous Spatial Spread of Dengue-Suppressing Wolbachia through an Urban Population of Aedes Aegypti.” PLoS Biology, vol. 15, no. 5, e2001894, Public Library of Science, 2017, doi:10.1371/journal.pbio.2001894.","apa":"Schmidt, T., Barton, N. H., Rasic, G., Turley, A., Montgomery, B., Iturbe Ormaetxe, I., … Turelli, M. (2017). Local introduction and heterogeneous spatial spread of dengue-suppressing Wolbachia through an urban population of Aedes Aegypti. PLoS Biology. Public Library of Science. https://doi.org/10.1371/journal.pbio.2001894","ieee":"T. Schmidt et al., “Local introduction and heterogeneous spatial spread of dengue-suppressing Wolbachia through an urban population of Aedes Aegypti,” PLoS Biology, vol. 15, no. 5. Public Library of Science, 2017.","ista":"Schmidt T, Barton NH, Rasic G, Turley A, Montgomery B, Iturbe Ormaetxe I, Cook P, Ryan P, Ritchie S, Hoffmann A, O’Neill S, Turelli M. 2017. Local introduction and heterogeneous spatial spread of dengue-suppressing Wolbachia through an urban population of Aedes Aegypti. PLoS Biology. 15(5), e2001894.","ama":"Schmidt T, Barton NH, Rasic G, et al. Local introduction and heterogeneous spatial spread of dengue-suppressing Wolbachia through an urban population of Aedes Aegypti. PLoS Biology. 2017;15(5). doi:10.1371/journal.pbio.2001894"},"date_published":"2017-05-30T00:00:00Z","type":"journal_article","abstract":[{"text":"Dengue-suppressing Wolbachia strains are promising tools for arbovirus control, particularly as they have the potential to self-spread following local introductions. To test this, we followed the frequency of the transinfected Wolbachia strain wMel through Ae. aegypti in Cairns, Australia, following releases at 3 nonisolated locations within the city in early 2013. Spatial spread was analysed graphically using interpolation and by fitting a statistical model describing the position and width of the wave. For the larger 2 of the 3 releases (covering 0.97 km2 and 0.52 km2), we observed slow but steady spatial spread, at about 100–200 m per year, roughly consistent with theoretical predictions. In contrast, the smallest release (0.11 km2) produced erratic temporal and spatial dynamics, with little evidence of spread after 2 years. This is consistent with the prediction concerning fitness-decreasing Wolbachia transinfections that a minimum release area is needed to achieve stable local establishment and spread in continuous habitats. Our graphical and likelihood analyses produced broadly consistent estimates of wave speed and wave width. Spread at all sites was spatially heterogeneous, suggesting that environmental heterogeneity will affect large-scale Wolbachia transformations of urban mosquito populations. The persistence and spread of Wolbachia in release areas meeting minimum area requirements indicates the promise of successful large-scale population transfo","lang":"eng"}],"issue":"5","_id":"951","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","title":"Local introduction and heterogeneous spatial spread of dengue-suppressing Wolbachia through an urban population of Aedes Aegypti","ddc":["576"],"status":"public","intvolume":" 15","pubrep_id":"843","oa_version":"Published Version","file":[{"creator":"system","content_type":"application/pdf","file_size":5541206,"access_level":"open_access","file_name":"IST-2017-843-v1+1_journal.pbio.2001894.pdf","checksum":"107d290bd1159ec77b734eb2824b01c8","date_updated":"2020-07-14T12:48:16Z","date_created":"2018-12-12T10:08:30Z","file_id":"4691","relation":"main_file"}],"month":"05","publication_identifier":{"issn":["15449173"]},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"external_id":{"isi":["000402520000012"]},"quality_controlled":"1","isi":1,"doi":"10.1371/journal.pbio.2001894","language":[{"iso":"eng"}],"article_number":"e2001894","file_date_updated":"2020-07-14T12:48:16Z","publist_id":"6464","year":"2017","publication_status":"published","department":[{"_id":"NiBa"}],"publisher":"Public Library of Science","author":[{"last_name":"Schmidt","first_name":"Tom","full_name":"Schmidt, Tom"},{"id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","last_name":"Barton","full_name":"Barton, Nicholas H"},{"full_name":"Rasic, Gordana","last_name":"Rasic","first_name":"Gordana"},{"full_name":"Turley, Andrew","last_name":"Turley","first_name":"Andrew"},{"full_name":"Montgomery, Brian","last_name":"Montgomery","first_name":"Brian"},{"first_name":"Inaki","last_name":"Iturbe Ormaetxe","full_name":"Iturbe Ormaetxe, Inaki"},{"first_name":"Peter","last_name":"Cook","full_name":"Cook, Peter"},{"first_name":"Peter","last_name":"Ryan","full_name":"Ryan, Peter"},{"full_name":"Ritchie, Scott","first_name":"Scott","last_name":"Ritchie"},{"first_name":"Ary","last_name":"Hoffmann","full_name":"Hoffmann, Ary"},{"full_name":"O’Neill, Scott","first_name":"Scott","last_name":"O’Neill"},{"full_name":"Turelli, Michael","first_name":"Michael","last_name":"Turelli"}],"related_material":{"record":[{"id":"9856","relation":"research_data","status":"public"},{"id":"9857","relation":"research_data","status":"public"},{"relation":"research_data","status":"public","id":"9858"}]},"date_created":"2018-12-11T11:49:22Z","date_updated":"2023-09-22T10:02:52Z","volume":15},{"type":"research_data_reference","date_created":"2021-08-10T07:47:07Z","date_updated":"2023-09-22T10:02:51Z","oa_version":"Published Version","author":[{"full_name":"Schmidt, Tom","first_name":"Tom","last_name":"Schmidt"},{"last_name":"Barton","first_name":"Nicholas H","orcid":"0000-0002-8548-5240","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","full_name":"Barton, Nicholas H"},{"full_name":"Rasic, Gordana","first_name":"Gordana","last_name":"Rasic"},{"first_name":"Andrew","last_name":"Turley","full_name":"Turley, Andrew"},{"full_name":"Montgomery, Brian","first_name":"Brian","last_name":"Montgomery"},{"full_name":"Iturbe Ormaetxe, Inaki","last_name":"Iturbe Ormaetxe","first_name":"Inaki"},{"first_name":"Peter","last_name":"Cook","full_name":"Cook, Peter"},{"last_name":"Ryan","first_name":"Peter","full_name":"Ryan, Peter"},{"last_name":"Ritchie","first_name":"Scott","full_name":"Ritchie, Scott"},{"first_name":"Ary","last_name":"Hoffmann","full_name":"Hoffmann, Ary"},{"full_name":"O’Neill, Scott","first_name":"Scott","last_name":"O’Neill"},{"full_name":"Turelli, Michael","last_name":"Turelli","first_name":"Michael"}],"related_material":{"record":[{"id":"951","status":"public","relation":"used_in_publication"}]},"status":"public","title":"Excel file with data on mosquito densities, Wolbachia infection status and housing characteristics","department":[{"_id":"NiBa"}],"publisher":"Public Library of Science","_id":"9858","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","year":"2017","month":"05","day":"30","article_processing_charge":"No","date_published":"2017-05-30T00:00:00Z","doi":"10.1371/journal.pbio.2001894.s016","citation":{"ama":"Schmidt T, Barton NH, Rasic G, et al. 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Excel File with Data on Mosquito Densities, Wolbachia Infection Status and Housing Characteristics. Public Library of Science, 2017, doi:10.1371/journal.pbio.2001894.s016.","short":"T. Schmidt, N.H. Barton, G. Rasic, A. Turley, B. Montgomery, I. Iturbe Ormaetxe, P. Cook, P. Ryan, S. Ritchie, A. Hoffmann, S. O’Neill, M. Turelli, (2017).","chicago":"Schmidt, Tom, Nicholas H Barton, Gordana Rasic, Andrew Turley, Brian Montgomery, Inaki Iturbe Ormaetxe, Peter Cook, et al. “Excel File with Data on Mosquito Densities, Wolbachia Infection Status and Housing Characteristics.” Public Library of Science, 2017. https://doi.org/10.1371/journal.pbio.2001894.s016."}},{"doi":"10.1371/journal.pbio.2001894.s015","date_published":"2017-05-30T00:00:00Z","citation":{"mla":"Schmidt, Tom, et al. Supporting Information Concerning Observed WMel Frequencies and Analyses of Habitat Variables. Public Library of Science , 2017, doi:10.1371/journal.pbio.2001894.s015.","short":"T. Schmidt, N.H. Barton, G. Rasic, A. Turley, B. Montgomery, I. Iturbe Ormaetxe, P. Cook, P. Ryan, S. Ritchie, A. Hoffmann, S. O’Neill, M. Turelli, (2017).","chicago":"Schmidt, Tom, Nicholas H Barton, Gordana Rasic, Andrew Turley, Brian Montgomery, Inaki Iturbe Ormaetxe, Peter Cook, et al. “Supporting Information Concerning Observed WMel Frequencies and Analyses of Habitat Variables.” Public Library of Science , 2017. https://doi.org/10.1371/journal.pbio.2001894.s015.","ama":"Schmidt T, Barton NH, Rasic G, et al. Supporting information concerning observed wMel frequencies and analyses of habitat variables. 2017. doi:10.1371/journal.pbio.2001894.s015","ista":"Schmidt T, Barton NH, Rasic G, Turley A, Montgomery B, Iturbe Ormaetxe I, Cook P, Ryan P, Ritchie S, Hoffmann A, O’Neill S, Turelli M. 2017. Supporting information concerning observed wMel frequencies and analyses of habitat variables, Public Library of Science , 10.1371/journal.pbio.2001894.s015.","apa":"Schmidt, T., Barton, N. H., Rasic, G., Turley, A., Montgomery, B., Iturbe Ormaetxe, I., … Turelli, M. (2017). Supporting information concerning observed wMel frequencies and analyses of habitat variables. Public Library of Science . https://doi.org/10.1371/journal.pbio.2001894.s015","ieee":"T. Schmidt et al., “Supporting information concerning observed wMel frequencies and analyses of habitat variables.” Public Library of Science , 2017."},"month":"05","day":"30","article_processing_charge":"No","date_updated":"2023-09-22T10:02:51Z","date_created":"2021-08-10T07:41:52Z","oa_version":"Published Version","author":[{"first_name":"Tom","last_name":"Schmidt","full_name":"Schmidt, Tom"},{"full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","last_name":"Barton"},{"last_name":"Rasic","first_name":"Gordana","full_name":"Rasic, Gordana"},{"last_name":"Turley","first_name":"Andrew","full_name":"Turley, Andrew"},{"first_name":"Brian","last_name":"Montgomery","full_name":"Montgomery, Brian"},{"full_name":"Iturbe Ormaetxe, Inaki","first_name":"Inaki","last_name":"Iturbe Ormaetxe"},{"full_name":"Cook, Peter","last_name":"Cook","first_name":"Peter"},{"full_name":"Ryan, Peter","first_name":"Peter","last_name":"Ryan"},{"full_name":"Ritchie, Scott","first_name":"Scott","last_name":"Ritchie"},{"full_name":"Hoffmann, Ary","last_name":"Hoffmann","first_name":"Ary"},{"full_name":"O’Neill, Scott","first_name":"Scott","last_name":"O’Neill"},{"last_name":"Turelli","first_name":"Michael","full_name":"Turelli, Michael"}],"related_material":{"record":[{"id":"951","status":"public","relation":"used_in_publication"}]},"title":"Supporting information concerning observed wMel frequencies and analyses of habitat variables","status":"public","department":[{"_id":"NiBa"}],"publisher":"Public Library of Science ","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","_id":"9857","year":"2017","type":"research_data_reference"},{"type":"research_data_reference","related_material":{"record":[{"relation":"used_in_publication","status":"public","id":"951"}]},"author":[{"full_name":"Schmidt, Tom","last_name":"Schmidt","first_name":"Tom"},{"full_name":"Barton, Nicholas H","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","first_name":"Nicholas H","last_name":"Barton"},{"last_name":"Rasic","first_name":"Gordana","full_name":"Rasic, Gordana"},{"first_name":"Andrew","last_name":"Turley","full_name":"Turley, Andrew"},{"first_name":"Brian","last_name":"Montgomery","full_name":"Montgomery, Brian"},{"full_name":"Iturbe Ormaetxe, Inaki","last_name":"Iturbe Ormaetxe","first_name":"Inaki"},{"last_name":"Cook","first_name":"Peter","full_name":"Cook, Peter"},{"last_name":"Ryan","first_name":"Peter","full_name":"Ryan, Peter"},{"first_name":"Scott","last_name":"Ritchie","full_name":"Ritchie, Scott"},{"first_name":"Ary","last_name":"Hoffmann","full_name":"Hoffmann, Ary"},{"full_name":"O’Neill, Scott","first_name":"Scott","last_name":"O’Neill"},{"full_name":"Turelli, Michael","last_name":"Turelli","first_name":"Michael"}],"oa_version":"Published Version","date_updated":"2023-09-22T10:02:51Z","date_created":"2021-08-10T07:36:04Z","_id":"9856","user_id":"6785fbc1-c503-11eb-8a32-93094b40e1cf","year":"2017","publisher":"Public Library of Science","department":[{"_id":"NiBa"}],"title":"Supporting Information concerning additional likelihood analyses and results","status":"public","article_processing_charge":"No","month":"05","day":"30","doi":"10.1371/journal.pbio.2001894.s014","date_published":"2017-05-30T00:00:00Z","citation":{"chicago":"Schmidt, Tom, Nicholas H Barton, Gordana Rasic, Andrew Turley, Brian Montgomery, Inaki Iturbe Ormaetxe, Peter Cook, et al. “Supporting Information Concerning Additional Likelihood Analyses and Results.” Public Library of Science, 2017. https://doi.org/10.1371/journal.pbio.2001894.s014.","short":"T. Schmidt, N.H. Barton, G. Rasic, A. Turley, B. Montgomery, I. Iturbe Ormaetxe, P. Cook, P. Ryan, S. Ritchie, A. Hoffmann, S. O’Neill, M. Turelli, (2017).","mla":"Schmidt, Tom, et al. Supporting Information Concerning Additional Likelihood Analyses and Results. Public Library of Science, 2017, doi:10.1371/journal.pbio.2001894.s014.","ieee":"T. Schmidt et al., “Supporting Information concerning additional likelihood analyses and results.” Public Library of Science, 2017.","apa":"Schmidt, T., Barton, N. H., Rasic, G., Turley, A., Montgomery, B., Iturbe Ormaetxe, I., … Turelli, M. (2017). Supporting Information concerning additional likelihood analyses and results. Public Library of Science. https://doi.org/10.1371/journal.pbio.2001894.s014","ista":"Schmidt T, Barton NH, Rasic G, Turley A, Montgomery B, Iturbe Ormaetxe I, Cook P, Ryan P, Ritchie S, Hoffmann A, O’Neill S, Turelli M. 2017. Supporting Information concerning additional likelihood analyses and results, Public Library of Science, 10.1371/journal.pbio.2001894.s014.","ama":"Schmidt T, Barton NH, Rasic G, et al. Supporting Information concerning additional likelihood analyses and results. 2017. doi:10.1371/journal.pbio.2001894.s014"}},{"file_date_updated":"2020-07-14T12:48:15Z","publist_id":"6533","ec_funded":1,"year":"2017","publication_status":"published","department":[{"_id":"NiBa"}],"publisher":"Genetics Society of America","author":[{"id":"461468AE-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2519-824X","first_name":"Sebastian","last_name":"Novak","full_name":"Novak, Sebastian"},{"first_name":"Nicholas H","last_name":"Barton","id":"4880FE40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8548-5240","full_name":"Barton, Nicholas H"}],"date_updated":"2023-09-26T15:49:15Z","date_created":"2018-12-11T11:49:09Z","volume":207,"month":"10","oa":1,"external_id":{"isi":["000412232600019"]},"quality_controlled":"1","isi":1,"project":[{"_id":"25B1EC9E-B435-11E9-9278-68D0E5697425","grant_number":"618091","name":"Speed of Adaptation in Population Genetics and Evolutionary Computation","call_identifier":"FP7"}],"doi":"10.1534/genetics.117.300129","language":[{"iso":"eng"}],"type":"journal_article","abstract":[{"text":"Frequency-independent selection is generally considered as a force that acts to reduce the genetic variation in evolving populations, yet rigorous arguments for this idea are scarce. When selection fluctuates in time, it is unclear whether frequency-independent selection may maintain genetic polymorphism without invoking additional mechanisms. We show that constant frequency-independent selection with arbitrary epistasis on a well-mixed haploid population eliminates genetic variation if we assume linkage equilibrium between alleles. To this end, we introduce the notion of frequency-independent selection at the level of alleles, which is sufficient to prove our claim and contains the notion of frequency-independent selection on haploids. When selection and recombination are weak but of the same order, there may be strong linkage disequilibrium; numerical calculations show that stable equilibria are highly unlikely. Using the example of a diallelic two-locus model, we then demonstrate that frequency-independent selection that fluctuates in time can maintain stable polymorphism if linkage disequilibrium changes its sign periodically. We put our findings in the context of results from the existing literature and point out those scenarios in which the possible role of frequency-independent selection in maintaining genetic variation remains unclear.\r\n","lang":"eng"}],"issue":"2","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","_id":"910","title":"When does frequency-independent selection maintain genetic variation?","ddc":["576"],"status":"public","intvolume":" 207","pubrep_id":"974","oa_version":"Submitted Version","file":[{"file_id":"5264","relation":"main_file","date_created":"2018-12-12T10:17:12Z","date_updated":"2020-07-14T12:48:15Z","checksum":"f7c32dabf52e6d9e709d9203761e39fd","file_name":"IST-2018-974-v1+1_manuscript.pdf","access_level":"open_access","creator":"system","content_type":"application/pdf","file_size":494268}],"scopus_import":"1","day":"01","has_accepted_license":"1","article_processing_charge":"No","publication":"Genetics","citation":{"chicago":"Novak, Sebastian, and Nicholas H Barton. “When Does Frequency-Independent Selection Maintain Genetic Variation?” Genetics. Genetics Society of America, 2017. https://doi.org/10.1534/genetics.117.300129.","short":"S. Novak, N.H. Barton, Genetics 207 (2017) 653–668.","mla":"Novak, Sebastian, and Nicholas H. Barton. “When Does Frequency-Independent Selection Maintain Genetic Variation?” Genetics, vol. 207, no. 2, Genetics Society of America, 2017, pp. 653–68, doi:10.1534/genetics.117.300129.","apa":"Novak, S., & Barton, N. H. (2017). When does frequency-independent selection maintain genetic variation? Genetics. Genetics Society of America. https://doi.org/10.1534/genetics.117.300129","ieee":"S. Novak and N. H. Barton, “When does frequency-independent selection maintain genetic variation?,” Genetics, vol. 207, no. 2. Genetics Society of America, pp. 653–668, 2017.","ista":"Novak S, Barton NH. 2017. When does frequency-independent selection maintain genetic variation? Genetics. 207(2), 653–668.","ama":"Novak S, Barton NH. When does frequency-independent selection maintain genetic variation? Genetics. 2017;207(2):653-668. doi:10.1534/genetics.117.300129"},"page":"653 - 668","date_published":"2017-10-01T00:00:00Z"}]