---
_id: '6466'
abstract:
- lang: eng
text: "One of the most striking and consistent results in speciation genomics is
the heterogeneous divergence observed across the genomes of closely related species.
This pattern was initially attributed to different levels of gene exchange—with
divergence preserved at loci generating a barrier to gene flow but homogenized
at unlinked neutral loci. Although there is evidence to support this model, it
is now recognized that interpreting patterns of divergence across genomes is not
so straightforward. One \r\nproblem is that heterogenous divergence between populations
can also be generated by other processes (e.g. recurrent selective sweeps or background
selection) without any involvement of differential gene flow. Thus, integrated
studies that identify which loci are likely subject to divergent selection are
required to shed light on the interplay between selection and gene flow during
the early phases of speciation. In this issue of Molecular Ecology, Rifkin et
al. (2019) confront this challenge using a pair of sister morning glory species.
They wisely design their sampling to take the geographic context of individuals
into account, including geographically isolated (allopatric) and co‐occurring
(sympatric) populations. This enabled them to show that individuals are phenotypically
less differentiated in sympatry. They also found that the loci that resist introgression
are enriched for those most differentiated in allopatry and loci that exhibit
signals of divergent selection. One great strength of the \r\nstudy is the combination
of methods from population genetics and molecular evolution, including the development
of a model to simultaneously infer admixture proportions and selfing rates."
article_processing_charge: No
author:
- first_name: David
full_name: Field, David
id: 419049E2-F248-11E8-B48F-1D18A9856A87
last_name: Field
orcid: 0000-0002-4014-8478
- first_name: Christelle
full_name: Fraisse, Christelle
id: 32DF5794-F248-11E8-B48F-1D18A9856A87
last_name: Fraisse
orcid: 0000-0001-8441-5075
citation:
ama: Field D, Fraisse C. Breaking down barriers in morning glories. Molecular
ecology. 2019;28(7):1579-1581. doi:10.1111/mec.15048
apa: Field, D., & Fraisse, C. (2019). Breaking down barriers in morning glories.
Molecular Ecology. Wiley. https://doi.org/10.1111/mec.15048
chicago: Field, David, and Christelle Fraisse. “Breaking down Barriers in Morning
Glories.” Molecular Ecology. Wiley, 2019. https://doi.org/10.1111/mec.15048.
ieee: D. Field and C. Fraisse, “Breaking down barriers in morning glories,” Molecular
ecology, vol. 28, no. 7. Wiley, pp. 1579–1581, 2019.
ista: Field D, Fraisse C. 2019. Breaking down barriers in morning glories. Molecular
ecology. 28(7), 1579–1581.
mla: Field, David, and Christelle Fraisse. “Breaking down Barriers in Morning Glories.”
Molecular Ecology, vol. 28, no. 7, Wiley, 2019, pp. 1579–81, doi:10.1111/mec.15048.
short: D. Field, C. Fraisse, Molecular Ecology 28 (2019) 1579–1581.
date_created: 2019-05-19T21:59:15Z
date_published: 2019-04-01T00:00:00Z
date_updated: 2023-08-25T10:37:30Z
day: '01'
ddc:
- '580'
- '576'
department:
- _id: NiBa
doi: 10.1111/mec.15048
external_id:
isi:
- '000474808300001'
file:
- access_level: open_access
checksum: 521e3aff3e9263ddf2ffbfe0b6157715
content_type: application/pdf
creator: dernst
date_created: 2019-05-20T11:49:06Z
date_updated: 2020-07-14T12:47:31Z
file_id: '6472'
file_name: 2019_MolecularEcology_Field.pdf
file_size: 367711
relation: main_file
file_date_updated: 2020-07-14T12:47:31Z
has_accepted_license: '1'
intvolume: ' 28'
isi: 1
issue: '7'
language:
- iso: eng
month: '04'
oa: 1
oa_version: Published Version
page: 1579-1581
publication: Molecular ecology
publication_identifier:
eissn:
- 1365294X
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Breaking down barriers in morning glories
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 28
year: '2019'
...
---
_id: '6467'
abstract:
- lang: eng
text: Fitness interactions between mutations can influence a population’s evolution
in many different ways. While epistatic effects are difficult to measure precisely,
important information is captured by the mean and variance of log fitnesses for
individuals carrying different numbers of mutations. We derive predictions for
these quantities from a class of simple fitness landscapes, based on models of
optimizing selection on quantitative traits. We also explore extensions to the
models, including modular pleiotropy, variable effect sizes, mutational bias and
maladaptation of the wild type. We illustrate our approach by reanalysing a large
dataset of mutant effects in a yeast snoRNA (small nucleolar RNA). Though characterized
by some large epistatic effects, these data give a good overall fit to the non-epistatic
null model, suggesting that epistasis might have limited influence on the evolutionary
dynamics in this system. We also show how the amount of epistasis depends on both
the underlying fitness landscape and the distribution of mutations, and so is
expected to vary in consistent ways between new mutations, standing variation
and fixed mutations.
article_number: '0881'
article_processing_charge: No
article_type: original
author:
- first_name: Christelle
full_name: Fraisse, Christelle
id: 32DF5794-F248-11E8-B48F-1D18A9856A87
last_name: Fraisse
orcid: 0000-0001-8441-5075
- first_name: John J.
full_name: Welch, John J.
last_name: Welch
citation:
ama: Fraisse C, Welch JJ. The distribution of epistasis on simple fitness landscapes.
Biology Letters. 2019;15(4). doi:10.1098/rsbl.2018.0881
apa: Fraisse, C., & Welch, J. J. (2019). The distribution of epistasis on simple
fitness landscapes. Biology Letters. Royal Society of London. https://doi.org/10.1098/rsbl.2018.0881
chicago: Fraisse, Christelle, and John J. Welch. “The Distribution of Epistasis
on Simple Fitness Landscapes.” Biology Letters. Royal Society of London,
2019. https://doi.org/10.1098/rsbl.2018.0881.
ieee: C. Fraisse and J. J. Welch, “The distribution of epistasis on simple fitness
landscapes,” Biology Letters, vol. 15, no. 4. Royal Society of London,
2019.
ista: Fraisse C, Welch JJ. 2019. The distribution of epistasis on simple fitness
landscapes. Biology Letters. 15(4), 0881.
mla: Fraisse, Christelle, and John J. Welch. “The Distribution of Epistasis on Simple
Fitness Landscapes.” Biology Letters, vol. 15, no. 4, 0881, Royal Society
of London, 2019, doi:10.1098/rsbl.2018.0881.
short: C. Fraisse, J.J. Welch, Biology Letters 15 (2019).
date_created: 2019-05-19T21:59:15Z
date_published: 2019-04-03T00:00:00Z
date_updated: 2023-08-25T10:34:41Z
day: '03'
department:
- _id: BeVi
- _id: NiBa
doi: 10.1098/rsbl.2018.0881
ec_funded: 1
external_id:
isi:
- '000465405300010'
pmid:
- '31014191'
intvolume: ' 15'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1098/rsbl.2018.0881
month: '04'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 25681D80-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '291734'
name: International IST Postdoc Fellowship Programme
publication: Biology Letters
publication_identifier:
eissn:
- 1744957X
issn:
- '17449561'
publication_status: published
publisher: Royal Society of London
quality_controlled: '1'
related_material:
link:
- relation: supplementary_material
url: https://dx.doi.org/10.6084/m9.figshare.c.4461008
record:
- id: '9798'
relation: research_data
status: public
- id: '9799'
relation: research_data
status: public
scopus_import: '1'
status: public
title: The distribution of epistasis on simple fitness landscapes
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 15
year: '2019'
...
---
_id: '6637'
abstract:
- lang: eng
text: The environment changes constantly at various time scales and, in order to
survive, species need to keep adapting. Whether these species succeed in avoiding
extinction is a major evolutionary question. Using a multilocus evolutionary model
of a mutation‐limited population adapting under strong selection, we investigate
the effects of the frequency of environmental fluctuations on adaptation. Our
results rely on an “adaptive‐walk” approximation and use mathematical methods
from evolutionary computation theory to investigate the interplay between fluctuation
frequency, the similarity of environments, and the number of loci contributing
to adaptation. First, we assume a linear additive fitness function, but later
generalize our results to include several types of epistasis. We show that frequent
environmental changes prevent populations from reaching a fitness peak, but they
may also prevent the large fitness loss that occurs after a single environmental
change. Thus, the population can survive, although not thrive, in a wide range
of conditions. Furthermore, we show that in a frequently changing environment,
the similarity of threats that a population faces affects the level of adaptation
that it is able to achieve. We check and supplement our analytical results with
simulations.
acknowledgement: The authors would like to thank to Tiago Paixao and Nick Barton for
useful comments and advice.
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Barbora
full_name: Trubenova, Barbora
id: 42302D54-F248-11E8-B48F-1D18A9856A87
last_name: Trubenova
orcid: 0000-0002-6873-2967
- first_name: 'Martin '
full_name: 'Krejca, Martin '
last_name: Krejca
- first_name: Per Kristian
full_name: Lehre, Per Kristian
last_name: Lehre
- first_name: Timo
full_name: Kötzing, Timo
last_name: Kötzing
citation:
ama: 'Trubenova B, Krejca M, Lehre PK, Kötzing T. Surfing on the seascape: Adaptation
in a changing environment. Evolution. 2019;73(7):1356-1374. doi:10.1111/evo.13784'
apa: 'Trubenova, B., Krejca, M., Lehre, P. K., & Kötzing, T. (2019). Surfing
on the seascape: Adaptation in a changing environment. Evolution. Wiley.
https://doi.org/10.1111/evo.13784'
chicago: 'Trubenova, Barbora, Martin Krejca, Per Kristian Lehre, and Timo Kötzing.
“Surfing on the Seascape: Adaptation in a Changing Environment.” Evolution.
Wiley, 2019. https://doi.org/10.1111/evo.13784.'
ieee: 'B. Trubenova, M. Krejca, P. K. Lehre, and T. Kötzing, “Surfing on the seascape:
Adaptation in a changing environment,” Evolution, vol. 73, no. 7. Wiley,
pp. 1356–1374, 2019.'
ista: 'Trubenova B, Krejca M, Lehre PK, Kötzing T. 2019. Surfing on the seascape:
Adaptation in a changing environment. Evolution. 73(7), 1356–1374.'
mla: 'Trubenova, Barbora, et al. “Surfing on the Seascape: Adaptation in a Changing
Environment.” Evolution, vol. 73, no. 7, Wiley, 2019, pp. 1356–74, doi:10.1111/evo.13784.'
short: B. Trubenova, M. Krejca, P.K. Lehre, T. Kötzing, Evolution 73 (2019) 1356–1374.
date_created: 2019-07-14T21:59:20Z
date_published: 2019-07-01T00:00:00Z
date_updated: 2023-08-29T06:31:14Z
day: '01'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1111/evo.13784
ec_funded: 1
external_id:
isi:
- '000474031600001'
file:
- access_level: open_access
checksum: 9831ca65def2d62498c7b08338b6d237
content_type: application/pdf
creator: apreinsp
date_created: 2019-07-16T06:08:31Z
date_updated: 2020-07-14T12:47:34Z
file_id: '6643'
file_name: 2019_Evolution_TrubenovaBarbora.pdf
file_size: 815416
relation: main_file
file_date_updated: 2020-07-14T12:47:34Z
has_accepted_license: '1'
intvolume: ' 73'
isi: 1
issue: '7'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '07'
oa: 1
oa_version: Published Version
page: 1356-1374
project:
- _id: 25AEDD42-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '704172'
name: Rate of Adaptation in Changing Environment
- _id: 25B1EC9E-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '618091'
name: Speed of Adaptation in Population Genetics and Evolutionary Computation
publication: Evolution
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Surfing on the seascape: Adaptation in a changing environment'
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 73
year: '2019'
...
---
_id: '6680'
abstract:
- lang: eng
text: This paper analyzes how partial selfing in a large source population influences
its ability to colonize a new habitat via the introduction of a few founder individuals.
Founders experience inbreeding depression due to partially recessive deleterious
alleles as well as maladaptation to the new environment due to selection on a
large number of additive loci. I first introduce a simplified version of the Inbreeding
History Model (Kelly, 2007) in order to characterize mutation‐selection balance
in a large, partially selfing source population under selection involving multiple
non‐identical loci. I then use individual‐based simulations to study the eco‐evolutionary
dynamics of founders establishing in the new habitat under a model of hard selection.
The study explores how selfing rate shapes establishment probabilities of founders
via effects on both inbreeding depression and adaptability to the new environment,
and also distinguishes the effects of selfing on the initial fitness of founders
from its effects on the long‐term adaptive response of the populations they found.
A high rate of (but not complete) selfing is found to aid establishment over a
wide range of parameters, even in the absence of mate limitation. The sensitivity
of the results to assumptions about the nature of polygenic selection are discussed.
article_processing_charge: Yes (via OA deal)
author:
- first_name: Himani
full_name: Sachdeva, Himani
id: 42377A0A-F248-11E8-B48F-1D18A9856A87
last_name: Sachdeva
citation:
ama: Sachdeva H. Effect of partial selfing and polygenic selection on establishment
in a new habitat. Evolution. 2019;73(9):1729-1745. doi:10.1111/evo.13812
apa: Sachdeva, H. (2019). Effect of partial selfing and polygenic selection on establishment
in a new habitat. Evolution. Wiley. https://doi.org/10.1111/evo.13812
chicago: Sachdeva, Himani. “Effect of Partial Selfing and Polygenic Selection on
Establishment in a New Habitat.” Evolution. Wiley, 2019. https://doi.org/10.1111/evo.13812.
ieee: H. Sachdeva, “Effect of partial selfing and polygenic selection on establishment
in a new habitat,” Evolution, vol. 73, no. 9. Wiley, pp. 1729–1745, 2019.
ista: Sachdeva H. 2019. Effect of partial selfing and polygenic selection on establishment
in a new habitat. Evolution. 73(9), 1729–1745.
mla: Sachdeva, Himani. “Effect of Partial Selfing and Polygenic Selection on Establishment
in a New Habitat.” Evolution, vol. 73, no. 9, Wiley, 2019, pp. 1729–45,
doi:10.1111/evo.13812.
short: H. Sachdeva, Evolution 73 (2019) 1729–1745.
date_created: 2019-07-25T09:08:28Z
date_published: 2019-09-01T00:00:00Z
date_updated: 2023-08-29T06:43:58Z
day: '01'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1111/evo.13812
external_id:
isi:
- '000481300600001'
file:
- access_level: open_access
checksum: 772ce7035965153959b946a1033de1ca
content_type: application/pdf
creator: kschuh
date_created: 2019-09-17T10:56:27Z
date_updated: 2020-07-14T12:47:37Z
file_id: '6881'
file_name: 2019_Evolution_Sachdeva.pdf
file_size: 937573
relation: main_file
file_date_updated: 2020-07-14T12:47:37Z
has_accepted_license: '1'
intvolume: ' 73'
isi: 1
issue: '9'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 1729-1745
publication: Evolution
publication_identifier:
eissn:
- 1558-5646
issn:
- 0014-3820
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '9802'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Effect of partial selfing and polygenic selection on establishment in a new
habitat
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 73
year: '2019'
...
---
_id: '9804'
abstract:
- lang: eng
text: Evolutionary studies are often limited by missing data that are critical to
understanding the history of selection. Selection experiments, which reproduce
rapid evolution under controlled conditions, are excellent tools to study how
genomes evolve under selection. Here we present a genomic dissection of the Longshanks
selection experiment, in which mice were selectively bred over 20 generations
for longer tibiae relative to body mass, resulting in 13% longer tibiae in two
replicates. We synthesized evolutionary theory, genome sequences and molecular
genetics to understand the selection response and found that it involved both
polygenic adaptation and discrete loci of major effect, with the strongest loci
tending to be selected in parallel between replicates. We show that selection
may favor de-repression of bone growth through inactivating two limb enhancers
of an inhibitor, Nkx3-2. Our integrative genomic analyses thus show that it is
possible to connect individual base-pair changes to the overall selection response.
article_processing_charge: No
author:
- first_name: João Pl
full_name: Castro, João Pl
last_name: Castro
- first_name: Michelle N.
full_name: Yancoskie, Michelle N.
last_name: Yancoskie
- first_name: Marta
full_name: Marchini, Marta
last_name: Marchini
- first_name: Stefanie
full_name: Belohlavy, Stefanie
id: 43FE426A-F248-11E8-B48F-1D18A9856A87
last_name: Belohlavy
orcid: 0000-0002-9849-498X
- first_name: Layla
full_name: Hiramatsu, Layla
last_name: Hiramatsu
- first_name: Marek
full_name: Kučka, Marek
last_name: Kučka
- first_name: William H.
full_name: Beluch, William H.
last_name: Beluch
- first_name: Ronald
full_name: Naumann, Ronald
last_name: Naumann
- first_name: Isabella
full_name: Skuplik, Isabella
last_name: Skuplik
- first_name: John
full_name: Cobb, John
last_name: Cobb
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Campbell
full_name: Rolian, Campbell
last_name: Rolian
- first_name: Yingguang Frank
full_name: Chan, Yingguang Frank
last_name: Chan
citation:
ama: 'Castro JP, Yancoskie MN, Marchini M, et al. Data from: An integrative genomic
analysis of the Longshanks selection experiment for longer limbs in mice. 2019.
doi:10.5061/dryad.0q2h6tk'
apa: 'Castro, J. P., Yancoskie, M. N., Marchini, M., Belohlavy, S., Hiramatsu, L.,
Kučka, M., … Chan, Y. F. (2019). Data from: An integrative genomic analysis of
the Longshanks selection experiment for longer limbs in mice. Dryad. https://doi.org/10.5061/dryad.0q2h6tk'
chicago: 'Castro, João Pl, Michelle N. Yancoskie, Marta Marchini, Stefanie Belohlavy,
Layla Hiramatsu, Marek Kučka, William H. Beluch, et al. “Data from: An Integrative
Genomic Analysis of the Longshanks Selection Experiment for Longer Limbs in Mice.”
Dryad, 2019. https://doi.org/10.5061/dryad.0q2h6tk.'
ieee: 'J. P. Castro et al., “Data from: An integrative genomic analysis of
the Longshanks selection experiment for longer limbs in mice.” Dryad, 2019.'
ista: 'Castro JP, Yancoskie MN, Marchini M, Belohlavy S, Hiramatsu L, Kučka M, Beluch
WH, Naumann R, Skuplik I, Cobb J, Barton NH, Rolian C, Chan YF. 2019. Data from:
An integrative genomic analysis of the Longshanks selection experiment for longer
limbs in mice, Dryad, 10.5061/dryad.0q2h6tk.'
mla: 'Castro, João Pl, et al. Data from: An Integrative Genomic Analysis of the
Longshanks Selection Experiment for Longer Limbs in Mice. Dryad, 2019, doi:10.5061/dryad.0q2h6tk.'
short: J.P. Castro, M.N. Yancoskie, M. Marchini, S. Belohlavy, L. Hiramatsu, M.
Kučka, W.H. Beluch, R. Naumann, I. Skuplik, J. Cobb, N.H. Barton, C. Rolian, Y.F.
Chan, (2019).
date_created: 2021-08-06T11:52:54Z
date_published: 2019-06-06T00:00:00Z
date_updated: 2023-08-29T06:41:51Z
day: '06'
department:
- _id: NiBa
doi: 10.5061/dryad.0q2h6tk
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.0q2h6tk
month: '06'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '6713'
relation: used_in_publication
status: public
status: public
title: 'Data from: An integrative genomic analysis of the Longshanks selection experiment
for longer limbs in mice'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2019'
...
---
_id: '9802'
abstract:
- lang: eng
text: This paper analyzes how partial selfing in a large source population influences
its ability to colonize a new habitat via the introduction of a few founder individuals.
Founders experience inbreeding depression due to partially recessive deleterious
alleles as well as maladaptation to the new environment due to selection on a
large number of additive loci. I first introduce a simplified version of the Inbreeding
History Model (Kelly, 2007) in order to characterize mutation-selection balance
in a large, partially selfing source population under selection involving multiple
non-identical loci. I then use individual-based simulations to study the eco-evolutionary
dynamics of founders establishing in the new habitat under a model of hard selection.
The study explores how selfing rate shapes establishment probabilities of founders
via effects on both inbreeding depression and adaptability to the new environment,
and also distinguishes the effects of selfing on the initial fitness of founders
from its effects on the long-term adaptive response of the populations they found.
A high rate of (but not complete) selfing is found to aid establishment over a
wide range of parameters, even in the absence of mate limitation. The sensitivity
of the results to assumptions about the nature of polygenic selection are discussed.
article_processing_charge: No
author:
- first_name: Himani
full_name: Sachdeva, Himani
id: 42377A0A-F248-11E8-B48F-1D18A9856A87
last_name: Sachdeva
citation:
ama: 'Sachdeva H. Data from: Effect of partial selfing and polygenic selection on
establishment in a new habitat. 2019. doi:10.5061/dryad.8tp0900'
apa: 'Sachdeva, H. (2019). Data from: Effect of partial selfing and polygenic selection
on establishment in a new habitat. Dryad. https://doi.org/10.5061/dryad.8tp0900'
chicago: 'Sachdeva, Himani. “Data from: Effect of Partial Selfing and Polygenic
Selection on Establishment in a New Habitat.” Dryad, 2019. https://doi.org/10.5061/dryad.8tp0900.'
ieee: 'H. Sachdeva, “Data from: Effect of partial selfing and polygenic selection
on establishment in a new habitat.” Dryad, 2019.'
ista: 'Sachdeva H. 2019. Data from: Effect of partial selfing and polygenic selection
on establishment in a new habitat, Dryad, 10.5061/dryad.8tp0900.'
mla: 'Sachdeva, Himani. Data from: Effect of Partial Selfing and Polygenic Selection
on Establishment in a New Habitat. Dryad, 2019, doi:10.5061/dryad.8tp0900.'
short: H. Sachdeva, (2019).
date_created: 2021-08-06T11:45:11Z
date_published: 2019-07-16T00:00:00Z
date_updated: 2023-08-29T06:43:57Z
day: '16'
department:
- _id: NiBa
doi: 10.5061/dryad.8tp0900
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.8tp0900
month: '07'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '6680'
relation: used_in_publication
status: public
status: public
title: 'Data from: Effect of partial selfing and polygenic selection on establishment
in a new habitat'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2019'
...
---
_id: '6795'
abstract:
- lang: eng
text: The green‐beard effect is one proposed mechanism predicted to underpin the
evolu‐tion of altruistic behavior. It relies on the recognition and the selective
help of altruists to each other in order to promote and sustain altruistic behavior.
However, this mechanism has often been dismissed as unlikely or uncommon, as it
is assumed that both the signaling trait and altruistic trait need to be encoded
by the same gene or through tightly linked genes. Here, we use models of indirect
genetic effects (IGEs) to find the minimum correlation between the signaling and
altruistic trait required for the evolution of the latter. We show that this correlation
threshold depends on the strength of the interaction (influence of the green beard
on the expression of the altruistic trait), as well as the costs and benefits
of the altruistic behavior. We further show that this correlation does not necessarily
have to be high and support our analytical results by simulations.
article_processing_charge: No
article_type: original
author:
- first_name: Barbora
full_name: Trubenova, Barbora
id: 42302D54-F248-11E8-B48F-1D18A9856A87
last_name: Trubenova
orcid: 0000-0002-6873-2967
- first_name: Reinmar
full_name: Hager, Reinmar
last_name: Hager
citation:
ama: Trubenova B, Hager R. Green beards in the light of indirect genetic effects.
Ecology and Evolution. 2019;9(17):9597-9608. doi:10.1002/ece3.5484
apa: Trubenova, B., & Hager, R. (2019). Green beards in the light of indirect
genetic effects. Ecology and Evolution. Wiley. https://doi.org/10.1002/ece3.5484
chicago: Trubenova, Barbora, and Reinmar Hager. “Green Beards in the Light of Indirect
Genetic Effects.” Ecology and Evolution. Wiley, 2019. https://doi.org/10.1002/ece3.5484.
ieee: B. Trubenova and R. Hager, “Green beards in the light of indirect genetic
effects,” Ecology and Evolution, vol. 9, no. 17. Wiley, pp. 9597–9608,
2019.
ista: Trubenova B, Hager R. 2019. Green beards in the light of indirect genetic
effects. Ecology and Evolution. 9(17), 9597–9608.
mla: Trubenova, Barbora, and Reinmar Hager. “Green Beards in the Light of Indirect
Genetic Effects.” Ecology and Evolution, vol. 9, no. 17, Wiley, 2019, pp.
9597–608, doi:10.1002/ece3.5484.
short: B. Trubenova, R. Hager, Ecology and Evolution 9 (2019) 9597–9608.
date_created: 2019-08-11T21:59:24Z
date_published: 2019-09-01T00:00:00Z
date_updated: 2023-08-29T07:03:10Z
day: '01'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1002/ece3.5484
ec_funded: 1
external_id:
isi:
- '000479973400001'
file:
- access_level: open_access
checksum: adcb70af4901977d95b8747eeee01bd7
content_type: application/pdf
creator: dernst
date_created: 2019-08-12T07:30:30Z
date_updated: 2020-07-14T12:47:40Z
file_id: '6799'
file_name: 2019_EcologyEvolution_Trubenova.pdf
file_size: 2839636
relation: main_file
file_date_updated: 2020-07-14T12:47:40Z
has_accepted_license: '1'
intvolume: ' 9'
isi: 1
issue: '17'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 9597-9608
project:
- _id: 25AEDD42-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '704172'
name: Rate of Adaptation in Changing Environment
publication: Ecology and Evolution
publication_identifier:
eissn:
- '20457758'
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Green beards in the light of indirect genetic effects
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 9
year: '2019'
...
---
_id: '6831'
abstract:
- lang: eng
text: "* Understanding the mechanisms causing phenotypic differences between females
and males has long fascinated evolutionary biologists. An extensive literature
exists on animal sexual dimorphism but less information is known about sex differences
in plants, particularly the extent of geographical variation in sexual dimorphism
and its life‐cycle dynamics.\r\n* Here, we investigated patterns of genetically
based sexual dimorphism in vegetative and reproductive traits of a wind‐pollinated
dioecious plant, Rumex hastatulus, across three life‐cycle stages using open‐pollinated
families from 30 populations spanning the geographic range and chromosomal variation
(XY and XY1Y2) of the species.\r\n* The direction and degree of sexual dimorphism
was highly variable among populations and life‐cycle stages. Sex‐specific differences
in reproductive function explained a significant amount of temporal change in
sexual dimorphism. For several traits, geographical variation in sexual dimorphism
was associated with bioclimatic parameters, likely due to the differential responses
of the sexes to climate. We found no systematic differences in sexual dimorphism
between chromosome races.\r\n* Sex‐specific trait differences in dioecious plants
largely result from a balance between sexual and natural selection on resource
allocation. Our results indicate that abiotic factors associated with geographical
context also play a role in modifying sexual dimorphism during the plant life‐cycle."
article_processing_charge: Yes (via OA deal)
article_type: original
author:
- first_name: Gemma
full_name: Puixeu Sala, Gemma
id: 33AB266C-F248-11E8-B48F-1D18A9856A87
last_name: Puixeu Sala
orcid: 0000-0001-8330-1754
- first_name: Melinda
full_name: Pickup, Melinda
id: 2C78037E-F248-11E8-B48F-1D18A9856A87
last_name: Pickup
orcid: 0000-0001-6118-0541
- first_name: David
full_name: Field, David
last_name: Field
orcid: 0000-0002-4014-8478
- first_name: Spencer C.H.
full_name: Barrett, Spencer C.H.
last_name: Barrett
citation:
ama: 'Puixeu Sala G, Pickup M, Field D, Barrett SCH. Variation in sexual dimorphism
in a wind-pollinated plant: The influence of geographical context and life-cycle
dynamics. New Phytologist. 2019;224(3):1108-1120. doi:10.1111/nph.16050'
apa: 'Puixeu Sala, G., Pickup, M., Field, D., & Barrett, S. C. H. (2019). Variation
in sexual dimorphism in a wind-pollinated plant: The influence of geographical
context and life-cycle dynamics. New Phytologist. Wiley. https://doi.org/10.1111/nph.16050'
chicago: 'Puixeu Sala, Gemma, Melinda Pickup, David Field, and Spencer C.H. Barrett.
“Variation in Sexual Dimorphism in a Wind-Pollinated Plant: The Influence of Geographical
Context and Life-Cycle Dynamics.” New Phytologist. Wiley, 2019. https://doi.org/10.1111/nph.16050.'
ieee: 'G. Puixeu Sala, M. Pickup, D. Field, and S. C. H. Barrett, “Variation in
sexual dimorphism in a wind-pollinated plant: The influence of geographical context
and life-cycle dynamics,” New Phytologist, vol. 224, no. 3. Wiley, pp.
1108–1120, 2019.'
ista: 'Puixeu Sala G, Pickup M, Field D, Barrett SCH. 2019. Variation in sexual
dimorphism in a wind-pollinated plant: The influence of geographical context and
life-cycle dynamics. New Phytologist. 224(3), 1108–1120.'
mla: 'Puixeu Sala, Gemma, et al. “Variation in Sexual Dimorphism in a Wind-Pollinated
Plant: The Influence of Geographical Context and Life-Cycle Dynamics.” New
Phytologist, vol. 224, no. 3, Wiley, 2019, pp. 1108–20, doi:10.1111/nph.16050.'
short: G. Puixeu Sala, M. Pickup, D. Field, S.C.H. Barrett, New Phytologist 224
(2019) 1108–1120.
date_created: 2019-08-25T22:00:51Z
date_published: 2019-11-01T00:00:00Z
date_updated: 2023-08-29T07:17:07Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
- _id: BeVi
doi: 10.1111/nph.16050
ec_funded: 1
external_id:
isi:
- '000481376500001'
file:
- access_level: open_access
checksum: 6370e7567d96b7b562e77d8b89653f80
content_type: application/pdf
creator: apreinsp
date_created: 2019-08-27T12:44:54Z
date_updated: 2020-07-14T12:47:42Z
file_id: '6833'
file_name: 2019_NewPhytologist_Puixeu.pdf
file_size: 2314016
relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: ' 224'
isi: 1
issue: '3'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 1108-1120
project:
- _id: 2564DBCA-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '665385'
name: International IST Doctoral Program
publication: New Phytologist
publication_identifier:
eissn:
- 1469-8137
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '9803'
relation: research_data
status: public
- id: '14058'
relation: dissertation_contains
status: public
scopus_import: '1'
status: public
title: 'Variation in sexual dimorphism in a wind-pollinated plant: The influence of
geographical context and life-cycle dynamics'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 224
year: '2019'
...
---
_id: '9803'
abstract:
- lang: eng
text: Understanding the mechanisms causing phenotypic differences between females
and males has long fascinated evolutionary biologists. An extensive literature
exists on animal sexual dimorphism but less is known about sex differences in
plants, particularly the extent of geographical variation in sexual dimorphism
and its life-cycle dynamics. Here, we investigate patterns of genetically-based
sexual dimorphism in vegetative and reproductive traits of a wind-pollinated dioecious
plant, Rumex hastatulus, across three life-cycle stages using open-pollinated
families from 30 populations spanning the geographic range and chromosomal variation
(XY and XY1Y2) of the species. The direction and degree of sexual dimorphism was
highly variable among populations and life-cycle stages. Sex-specific differences
in reproductive function explained a significant amount of temporal change in
sexual dimorphism. For several traits, geographical variation in sexual dimorphism
was associated with bioclimatic parameters, likely due to the differential responses
of the sexes to climate. We found no systematic differences in sexual dimorphism
between chromosome races. Sex-specific trait differences in dioecious plants largely
result from a balance between sexual and natural selection on resource allocation.
Our results indicate that abiotic factors associated with geographical context
also play a role in modifying sexual dimorphism during the plant life cycle.
article_processing_charge: No
author:
- first_name: Gemma
full_name: Puixeu Sala, Gemma
id: 33AB266C-F248-11E8-B48F-1D18A9856A87
last_name: Puixeu Sala
orcid: 0000-0001-8330-1754
- first_name: Melinda
full_name: Pickup, Melinda
id: 2C78037E-F248-11E8-B48F-1D18A9856A87
last_name: Pickup
orcid: 0000-0001-6118-0541
- first_name: David
full_name: Field, David
last_name: Field
- first_name: Spencer C.H.
full_name: Barrett, Spencer C.H.
last_name: Barrett
citation:
ama: 'Puixeu Sala G, Pickup M, Field D, Barrett SCH. Data from: Variation in sexual
dimorphism in a wind-pollinated plant: the influence of geographical context and
life-cycle dynamics. 2019. doi:10.5061/dryad.n1701c9'
apa: 'Puixeu Sala, G., Pickup, M., Field, D., & Barrett, S. C. H. (2019). Data
from: Variation in sexual dimorphism in a wind-pollinated plant: the influence
of geographical context and life-cycle dynamics. Dryad. https://doi.org/10.5061/dryad.n1701c9'
chicago: 'Puixeu Sala, Gemma, Melinda Pickup, David Field, and Spencer C.H. Barrett.
“Data from: Variation in Sexual Dimorphism in a Wind-Pollinated Plant: The Influence
of Geographical Context and Life-Cycle Dynamics.” Dryad, 2019. https://doi.org/10.5061/dryad.n1701c9.'
ieee: 'G. Puixeu Sala, M. Pickup, D. Field, and S. C. H. Barrett, “Data from: Variation
in sexual dimorphism in a wind-pollinated plant: the influence of geographical
context and life-cycle dynamics.” Dryad, 2019.'
ista: 'Puixeu Sala G, Pickup M, Field D, Barrett SCH. 2019. Data from: Variation
in sexual dimorphism in a wind-pollinated plant: the influence of geographical
context and life-cycle dynamics, Dryad, 10.5061/dryad.n1701c9.'
mla: 'Puixeu Sala, Gemma, et al. Data from: Variation in Sexual Dimorphism in
a Wind-Pollinated Plant: The Influence of Geographical Context and Life-Cycle
Dynamics. Dryad, 2019, doi:10.5061/dryad.n1701c9.'
short: G. Puixeu Sala, M. Pickup, D. Field, S.C.H. Barrett, (2019).
date_created: 2021-08-06T11:48:42Z
date_published: 2019-07-22T00:00:00Z
date_updated: 2023-08-29T07:17:07Z
day: '22'
department:
- _id: NiBa
- _id: BeVi
doi: 10.5061/dryad.n1701c9
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.n1701c9
month: '07'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '14058'
relation: used_in_publication
status: public
- id: '6831'
relation: used_in_publication
status: public
status: public
title: 'Data from: Variation in sexual dimorphism in a wind-pollinated plant: the
influence of geographical context and life-cycle dynamics'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2019'
...
---
_id: '6855'
abstract:
- lang: eng
text: Many traits of interest are highly heritable and genetically complex, meaning
that much of the variation they exhibit arises from differences at numerous loci
in the genome. Complex traits and their evolution have been studied for more than
a century, but only in the last decade have genome-wide association studies (GWASs)
in humans begun to reveal their genetic basis. Here, we bring these threads of
research together to ask how findings from GWASs can further our understanding
of the processes that give rise to heritable variation in complex traits and of
the genetic basis of complex trait evolution in response to changing selection
pressures (i.e., of polygenic adaptation). Conversely, we ask how evolutionary
thinking helps us to interpret findings from GWASs and informs related efforts
of practical importance.
article_processing_charge: No
author:
- first_name: Guy
full_name: Sella, Guy
last_name: Sella
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Sella G, Barton NH. Thinking about the evolution of complex traits in the era
of genome-wide association studies. Annual Review of Genomics and Human Genetics.
2019;20:461-493. doi:10.1146/annurev-genom-083115-022316
apa: Sella, G., & Barton, N. H. (2019). Thinking about the evolution of complex
traits in the era of genome-wide association studies. Annual Review of Genomics
and Human Genetics. Annual Reviews. https://doi.org/10.1146/annurev-genom-083115-022316
chicago: Sella, Guy, and Nicholas H Barton. “Thinking about the Evolution of Complex
Traits in the Era of Genome-Wide Association Studies.” Annual Review of Genomics
and Human Genetics. Annual Reviews, 2019. https://doi.org/10.1146/annurev-genom-083115-022316.
ieee: G. Sella and N. H. Barton, “Thinking about the evolution of complex traits
in the era of genome-wide association studies,” Annual Review of Genomics and
Human Genetics, vol. 20. Annual Reviews, pp. 461–493, 2019.
ista: Sella G, Barton NH. 2019. Thinking about the evolution of complex traits in
the era of genome-wide association studies. Annual Review of Genomics and Human
Genetics. 20, 461–493.
mla: Sella, Guy, and Nicholas H. Barton. “Thinking about the Evolution of Complex
Traits in the Era of Genome-Wide Association Studies.” Annual Review of Genomics
and Human Genetics, vol. 20, Annual Reviews, 2019, pp. 461–93, doi:10.1146/annurev-genom-083115-022316.
short: G. Sella, N.H. Barton, Annual Review of Genomics and Human Genetics 20 (2019)
461–493.
date_created: 2019-09-07T14:28:29Z
date_published: 2019-07-05T00:00:00Z
date_updated: 2023-08-29T07:49:38Z
day: '05'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1146/annurev-genom-083115-022316
external_id:
isi:
- '000485148400020'
pmid:
- '31283361'
file:
- access_level: open_access
checksum: 23d3978cf4739a89ce2c3e779f9305ca
content_type: application/pdf
creator: dernst
date_created: 2019-09-09T07:22:12Z
date_updated: 2020-07-14T12:47:42Z
file_id: '6862'
file_name: 2019_AnnualReview_Sella.pdf
file_size: 411491
relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: ' 20'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 461-493
pmid: 1
publication: Annual Review of Genomics and Human Genetics
publication_identifier:
eissn:
- 1545-293X
issn:
- 1527-8204
publication_status: published
publisher: Annual Reviews
quality_controlled: '1'
scopus_import: '1'
status: public
title: Thinking about the evolution of complex traits in the era of genome-wide association
studies
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 20
year: '2019'
...
---
_id: '6858'
article_processing_charge: No
article_type: review
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: Barton NH. Is speciation driven by cycles of mixing and isolation? National
Science Review. 2019;6(2):291-292. doi:10.1093/nsr/nwy113
apa: Barton, N. H. (2019). Is speciation driven by cycles of mixing and isolation?
National Science Review. Oxford University Press. https://doi.org/10.1093/nsr/nwy113
chicago: Barton, Nicholas H. “Is Speciation Driven by Cycles of Mixing and Isolation?”
National Science Review. Oxford University Press, 2019. https://doi.org/10.1093/nsr/nwy113.
ieee: N. H. Barton, “Is speciation driven by cycles of mixing and isolation?,” National
Science Review, vol. 6, no. 2. Oxford University Press, pp. 291–292, 2019.
ista: Barton NH. 2019. Is speciation driven by cycles of mixing and isolation? National
Science Review. 6(2), 291–292.
mla: Barton, Nicholas H. “Is Speciation Driven by Cycles of Mixing and Isolation?”
National Science Review, vol. 6, no. 2, Oxford University Press, 2019,
pp. 291–92, doi:10.1093/nsr/nwy113.
short: N.H. Barton, National Science Review 6 (2019) 291–292.
date_created: 2019-09-07T14:43:02Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2023-08-29T07:51:09Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1093/nsr/nwy113
external_id:
isi:
- '000467957400025'
file:
- access_level: open_access
checksum: 571d60fa21a568607d1fd04e119da88c
content_type: application/pdf
creator: dernst
date_created: 2020-10-02T09:16:44Z
date_updated: 2020-10-02T09:16:44Z
file_id: '8595'
file_name: 2019_NSR_Barton.pdf
file_size: 106463
relation: main_file
success: 1
file_date_updated: 2020-10-02T09:16:44Z
has_accepted_license: '1'
intvolume: ' 6'
isi: 1
issue: '2'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: 291-292
publication: National Science Review
publication_identifier:
eissn:
- 2053-714X
issn:
- 2095-5138
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Is speciation driven by cycles of mixing and isolation?
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 6
year: '2019'
...
---
_id: '6857'
abstract:
- lang: eng
text: "Gene Drives are regarded as future tools with a high potential for population
control. Due to their inherent ability to overcome the rules of Mendelian inheritance,
gene drives (GD) may spread genes rapidly through populations of sexually reproducing
organisms. A release of organisms carrying a GD would constitute a paradigm shift
in the handling of genetically modified organisms because gene drive organisms
(GDO) are designed to drive their transgenes into wild populations and thereby
increase the number of GDOs. The rapid development in this field and its focus
on wild populations demand a prospective risk assessment with a focus on exposure
related aspects. Presently, it is unclear how adequate risk management could be
guaranteed to limit the spread of GDs in time and space, in order to avoid potential
adverse effects in socio‐ecological systems.\r\n\r\nThe recent workshop on the
“Evaluation of Spatial and Temporal Control of Gene Drives” hosted by the Institute
of Safety/Security and Risk Sciences (ISR) in Vienna aimed at gaining some insight
into the potential population dynamic behavior of GDs and appropriate measures
of control. Scientists from France, Germany, England, and the USA discussed both
topics in this meeting on April 4–5, 2019. This article summarizes results of
the workshop."
article_number: '1900151'
article_processing_charge: No
article_type: original
author:
- first_name: B
full_name: Giese, B
last_name: Giese
- first_name: J L
full_name: Friess, J L
last_name: Friess
- first_name: 'M F '
full_name: 'Schetelig, M F '
last_name: Schetelig
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Philip
full_name: Messer, Philip
last_name: Messer
- first_name: Florence
full_name: Debarre, Florence
last_name: Debarre
- first_name: H
full_name: Meimberg, H
last_name: Meimberg
- first_name: N
full_name: Windbichler, N
last_name: Windbichler
- first_name: C
full_name: Boete, C
last_name: Boete
citation:
ama: 'Giese B, Friess JL, Schetelig MF, et al. Gene Drives: Dynamics and regulatory
matters – A report from the workshop “Evaluation of spatial and temporal control
of Gene Drives”, 4 – 5 April 2019, Vienna. BioEssays. 2019;41(11). doi:10.1002/bies.201900151'
apa: 'Giese, B., Friess, J. L., Schetelig, M. F., Barton, N. H., Messer, P., Debarre,
F., … Boete, C. (2019). Gene Drives: Dynamics and regulatory matters – A report
from the workshop “Evaluation of spatial and temporal control of Gene Drives”,
4 – 5 April 2019, Vienna. BioEssays. Wiley. https://doi.org/10.1002/bies.201900151'
chicago: 'Giese, B, J L Friess, M F Schetelig, Nicholas H Barton, Philip Messer,
Florence Debarre, H Meimberg, N Windbichler, and C Boete. “Gene Drives: Dynamics
and Regulatory Matters – A Report from the Workshop ‘Evaluation of Spatial and
Temporal Control of Gene Drives’, 4 – 5 April 2019, Vienna.” BioEssays.
Wiley, 2019. https://doi.org/10.1002/bies.201900151.'
ieee: 'B. Giese et al., “Gene Drives: Dynamics and regulatory matters – A
report from the workshop ‘Evaluation of spatial and temporal control of Gene Drives’,
4 – 5 April 2019, Vienna,” BioEssays, vol. 41, no. 11. Wiley, 2019.'
ista: 'Giese B, Friess JL, Schetelig MF, Barton NH, Messer P, Debarre F, Meimberg
H, Windbichler N, Boete C. 2019. Gene Drives: Dynamics and regulatory matters
– A report from the workshop “Evaluation of spatial and temporal control of Gene
Drives”, 4 – 5 April 2019, Vienna. BioEssays. 41(11), 1900151.'
mla: 'Giese, B., et al. “Gene Drives: Dynamics and Regulatory Matters – A Report
from the Workshop ‘Evaluation of Spatial and Temporal Control of Gene Drives’,
4 – 5 April 2019, Vienna.” BioEssays, vol. 41, no. 11, 1900151, Wiley,
2019, doi:10.1002/bies.201900151.'
short: B. Giese, J.L. Friess, M.F. Schetelig, N.H. Barton, P. Messer, F. Debarre,
H. Meimberg, N. Windbichler, C. Boete, BioEssays 41 (2019).
date_created: 2019-09-07T14:40:03Z
date_published: 2019-11-01T00:00:00Z
date_updated: 2023-08-30T06:56:26Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1002/bies.201900151
external_id:
isi:
- '000489502000001'
file:
- access_level: open_access
checksum: 8cc7551bff70b2658f8d5630f228ee12
content_type: application/pdf
creator: dernst
date_created: 2019-10-11T06:59:26Z
date_updated: 2020-07-14T12:47:42Z
file_id: '6939'
file_name: 2019_BioEssays_Giese.pdf
file_size: 193248
relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: ' 41'
isi: 1
issue: '11'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: BioEssays
publication_identifier:
eissn:
- 1521-1878
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Gene Drives: Dynamics and regulatory matters – A report from the workshop
“Evaluation of spatial and temporal control of Gene Drives”, 4 – 5 April 2019, Vienna'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 41
year: '2019'
...
---
_id: '13067'
abstract:
- lang: eng
text: Genetic incompatibilities contribute to reproductive isolation between many
diverging populations, but it is still unclear to what extent they play a role
if divergence happens with gene flow. In contact zones between the "Crab" and
"Wave" ecotypes of the snail Littorina saxatilis divergent selection forms strong
barriers to gene flow, while the role of postzygotic barriers due to selection
against hybrids remains unclear. High embryo abortion rates in this species could
indicate the presence of such barriers. Postzygotic barriers might include genetic
incompatibilities (e.g. Dobzhansky-Muller incompatibilities) but also maladaptation,
both expected to be most pronounced in contact zones. In addition, embryo abortion
might reflect physiological stress on females and embryos independent of any genetic
stress. We examined all embryos of >500 females sampled outside and inside
contact zones of three populations in Sweden. Females' clutch size ranged from
0 to 1011 embryos (mean 130±123) and abortion rates varied between 0 and100% (mean
12%). We described female genotypes by using a hybrid index based on hundreds
of SNPs differentiated between ecotypes with which we characterised female genotypes.
We also calculated female SNP heterozygosity and inversion karyotype. Clutch size
did not vary with female hybrid index and abortion rates were only weakly related
to hybrid index in two sites but not at all in a third site. No additional variation
in abortion rate was explained by female SNP heterozygosity, but increased female
inversion heterozygosity added slightly to increased abortion. Our results show
only weak and probably biologically insignificant postzygotic barriers contributing
to ecotype divergence and the high and variable abortion rates were marginally,
if at all, explained by hybrid index of females.
article_processing_charge: No
author:
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Zuzanna
full_name: Zagrodzka, Zuzanna
last_name: Zagrodzka
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Roger
full_name: Butlin, Roger
last_name: Butlin
citation:
ama: 'Johannesson K, Zagrodzka Z, Faria R, Westram AM, Butlin R. Data from: Is embryo
abortion a postzygotic barrier to gene flow between Littorina ecotypes? 2019.
doi:10.5061/DRYAD.TB2RBNZWK'
apa: 'Johannesson, K., Zagrodzka, Z., Faria, R., Westram, A. M., & Butlin, R.
(2019). Data from: Is embryo abortion a postzygotic barrier to gene flow between
Littorina ecotypes? Dryad. https://doi.org/10.5061/DRYAD.TB2RBNZWK'
chicago: 'Johannesson, Kerstin, Zuzanna Zagrodzka, Rui Faria, Anja M Westram, and
Roger Butlin. “Data from: Is Embryo Abortion a Postzygotic Barrier to Gene Flow
between Littorina Ecotypes?” Dryad, 2019. https://doi.org/10.5061/DRYAD.TB2RBNZWK.'
ieee: 'K. Johannesson, Z. Zagrodzka, R. Faria, A. M. Westram, and R. Butlin, “Data
from: Is embryo abortion a postzygotic barrier to gene flow between Littorina
ecotypes?” Dryad, 2019.'
ista: 'Johannesson K, Zagrodzka Z, Faria R, Westram AM, Butlin R. 2019. Data from:
Is embryo abortion a postzygotic barrier to gene flow between Littorina ecotypes?,
Dryad, 10.5061/DRYAD.TB2RBNZWK.'
mla: 'Johannesson, Kerstin, et al. Data from: Is Embryo Abortion a Postzygotic
Barrier to Gene Flow between Littorina Ecotypes? Dryad, 2019, doi:10.5061/DRYAD.TB2RBNZWK.'
short: K. Johannesson, Z. Zagrodzka, R. Faria, A.M. Westram, R. Butlin, (2019).
date_created: 2023-05-23T16:36:27Z
date_published: 2019-12-02T00:00:00Z
date_updated: 2023-09-06T14:48:57Z
day: '02'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.5061/DRYAD.TB2RBNZWK
license: https://creativecommons.org/publicdomain/zero/1.0/
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.tb2rbnzwk
month: '12'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '7205'
relation: used_in_publication
status: public
status: public
title: 'Data from: Is embryo abortion a postzygotic barrier to gene flow between Littorina
ecotypes?'
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data_reference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...
---
_id: '7393'
abstract:
- lang: eng
text: The study of parallel ecological divergence provides important clues to the
operation of natural selection. Parallel divergence often occurs in heterogeneous
environments with different kinds of environmental gradients in different locations,
but the genomic basis underlying this process is unknown. We investigated the
genomics of rapid parallel adaptation in the marine snail Littorina saxatilis
in response to two independent environmental axes (crab-predation versus wave-action
and low-shore versus high-shore). Using pooled whole-genome resequencing, we show
that sharing of genomic regions of high differentiation between environments is
generally low but increases at smaller spatial scales. We identify different shared
genomic regions of divergence for each environmental axis and show that most of
these regions overlap with candidate chromosomal inversions. Several inversion
regions are divergent and polymorphic across many localities. We argue that chromosomal
inversions could store shared variation that fuels rapid parallel adaptation to
heterogeneous environments, possibly as balanced polymorphism shared by adaptive
gene flow.
article_number: eaav9963
article_processing_charge: No
article_type: original
author:
- first_name: Hernán E.
full_name: Morales, Hernán E.
last_name: Morales
- first_name: Rui
full_name: Faria, Rui
last_name: Faria
- first_name: Kerstin
full_name: Johannesson, Kerstin
last_name: Johannesson
- first_name: Tomas
full_name: Larsson, Tomas
last_name: Larsson
- first_name: Marina
full_name: Panova, Marina
last_name: Panova
- first_name: Anja M
full_name: Westram, Anja M
id: 3C147470-F248-11E8-B48F-1D18A9856A87
last_name: Westram
orcid: 0000-0003-1050-4969
- first_name: Roger K.
full_name: Butlin, Roger K.
last_name: Butlin
citation:
ama: 'Morales HE, Faria R, Johannesson K, et al. Genomic architecture of parallel
ecological divergence: Beyond a single environmental contrast. Science Advances.
2019;5(12). doi:10.1126/sciadv.aav9963'
apa: 'Morales, H. E., Faria, R., Johannesson, K., Larsson, T., Panova, M., Westram,
A. M., & Butlin, R. K. (2019). Genomic architecture of parallel ecological
divergence: Beyond a single environmental contrast. Science Advances. AAAS.
https://doi.org/10.1126/sciadv.aav9963'
chicago: 'Morales, Hernán E., Rui Faria, Kerstin Johannesson, Tomas Larsson, Marina
Panova, Anja M Westram, and Roger K. Butlin. “Genomic Architecture of Parallel
Ecological Divergence: Beyond a Single Environmental Contrast.” Science Advances.
AAAS, 2019. https://doi.org/10.1126/sciadv.aav9963.'
ieee: 'H. E. Morales et al., “Genomic architecture of parallel ecological
divergence: Beyond a single environmental contrast,” Science Advances,
vol. 5, no. 12. AAAS, 2019.'
ista: 'Morales HE, Faria R, Johannesson K, Larsson T, Panova M, Westram AM, Butlin
RK. 2019. Genomic architecture of parallel ecological divergence: Beyond a single
environmental contrast. Science Advances. 5(12), eaav9963.'
mla: 'Morales, Hernán E., et al. “Genomic Architecture of Parallel Ecological Divergence:
Beyond a Single Environmental Contrast.” Science Advances, vol. 5, no.
12, eaav9963, AAAS, 2019, doi:10.1126/sciadv.aav9963.'
short: H.E. Morales, R. Faria, K. Johannesson, T. Larsson, M. Panova, A.M. Westram,
R.K. Butlin, Science Advances 5 (2019).
date_created: 2020-01-29T15:58:27Z
date_published: 2019-12-04T00:00:00Z
date_updated: 2023-09-06T15:35:56Z
day: '04'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1126/sciadv.aav9963
ec_funded: 1
external_id:
isi:
- '000505069600008'
pmid:
- '31840052'
file:
- access_level: open_access
checksum: af99a5dcdc66c6d6102051faf3be48d8
content_type: application/pdf
creator: dernst
date_created: 2020-02-03T13:33:25Z
date_updated: 2020-07-14T12:47:57Z
file_id: '7442'
file_name: 2019_ScienceAdvances_Morales.pdf
file_size: 1869449
relation: main_file
file_date_updated: 2020-07-14T12:47:57Z
has_accepted_license: '1'
intvolume: ' 5'
isi: 1
issue: '12'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '12'
oa: 1
oa_version: Published Version
pmid: 1
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
- _id: 265B41B8-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '797747'
name: Theoretical and empirical approaches to understanding Parallel Adaptation
publication: Science Advances
publication_identifier:
issn:
- 2375-2548
publication_status: published
publisher: AAAS
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Genomic architecture of parallel ecological divergence: Beyond a single environmental
contrast'
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
volume: 5
year: '2019'
...
---
_id: '8281'
abstract:
- lang: eng
text: We review the history of population genetics, starting with its origins a
century ago from the synthesis between Mendel and Darwin's ideas, through to the
recent development of sophisticated schemes of inference from sequence data, based
on the coalescent. We explain the close relation between the coalescent and a
diffusion process, which we illustrate by their application to understand spatial
structure. We summarise the powerful methods available for analysis of multiple
loci, when linkage equilibrium can be assumed, and then discuss approaches to
the more challenging case, where associations between alleles require that we
follow genotype, rather than allele, frequencies. Though we can hardly cover the
whole of population genetics, we give an overview of the current state of the
subject, and future challenges to it.
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Alison
full_name: Etheridge, Alison
last_name: Etheridge
citation:
ama: 'Barton NH, Etheridge A. Mathematical models in population genetics. In: Balding
D, Moltke I, Marioni J, eds. Handbook of Statistical Genomics. 4th ed.
Wiley; 2019:115-144. doi:10.1002/9781119487845.ch4'
apa: Barton, N. H., & Etheridge, A. (2019). Mathematical models in population
genetics. In D. Balding, I. Moltke, & J. Marioni (Eds.), Handbook of statistical
genomics (4th ed., pp. 115–144). Wiley. https://doi.org/10.1002/9781119487845.ch4
chicago: Barton, Nicholas H, and Alison Etheridge. “Mathematical Models in Population
Genetics.” In Handbook of Statistical Genomics, edited by David Balding,
Ida Moltke, and John Marioni, 4th ed., 115–44. Wiley, 2019. https://doi.org/10.1002/9781119487845.ch4.
ieee: N. H. Barton and A. Etheridge, “Mathematical models in population genetics,”
in Handbook of statistical genomics, 4th ed., D. Balding, I. Moltke, and
J. Marioni, Eds. Wiley, 2019, pp. 115–144.
ista: 'Barton NH, Etheridge A. 2019.Mathematical models in population genetics.
In: Handbook of statistical genomics. , 115–144.'
mla: Barton, Nicholas H., and Alison Etheridge. “Mathematical Models in Population
Genetics.” Handbook of Statistical Genomics, edited by David Balding et
al., 4th ed., Wiley, 2019, pp. 115–44, doi:10.1002/9781119487845.ch4.
short: N.H. Barton, A. Etheridge, in:, D. Balding, I. Moltke, J. Marioni (Eds.),
Handbook of Statistical Genomics, 4th ed., Wiley, 2019, pp. 115–144.
date_created: 2020-08-21T04:25:39Z
date_published: 2019-07-29T00:00:00Z
date_updated: 2023-09-08T11:24:15Z
day: '29'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1002/9781119487845.ch4
edition: '4'
editor:
- first_name: David
full_name: Balding, David
last_name: Balding
- first_name: Ida
full_name: Moltke, Ida
last_name: Moltke
- first_name: John
full_name: Marioni, John
last_name: Marioni
external_id:
isi:
- '000261343000003'
isi: 1
language:
- iso: eng
month: '07'
oa_version: None
page: 115-144
publication: Handbook of statistical genomics
publication_identifier:
isbn:
- '9781119429142'
publication_status: published
publisher: Wiley
quality_controlled: '1'
status: public
title: Mathematical models in population genetics
type: book_chapter
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2019'
...
---
_id: '9805'
abstract:
- lang: eng
text: The spread of adaptive alleles is fundamental to evolution, and in theory,
this process is well‐understood. However, only rarely can we follow this process—whether
it originates from the spread of a new mutation, or by introgression from another
population. In this issue of Molecular Ecology, Hanemaaijer et al. (2018) report
on a 25‐year long study of the mosquitoes Anopheles gambiae (Figure 1) and Anopheles
coluzzi in Mali, based on genotypes at 15 single‐nucleotide polymorphism (SNP).
The species are usually reproductively isolated from each other, but in 2002 and
2006, bursts of hybridization were observed, when F1 hybrids became abundant.
Alleles backcrossed from A. gambiae into A. coluzzi, but after the first event,
these declined over the following years. In contrast, after 2006, an insecticide
resistance allele that had established in A. gambiae spread into A. coluzzi, and
rose to high frequency there, over 6 years (~75 generations). Whole genome sequences
of 74 individuals showed that A. gambiae SNP from across the genome had become
common in the A. coluzzi population, but that most of these were clustered in
34 genes around the resistance locus. A new set of SNP from 25 of these genes
were assayed over time; over the 4 years since near‐fixation of the resistance
allele; some remained common, whereas others declined. What do these patterns
tell us about this introgression event?
article_processing_charge: No
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Barton NH. Data from: The consequences of an introgression event. 2019. doi:10.5061/dryad.2kb6fh4'
apa: 'Barton, N. H. (2019). Data from: The consequences of an introgression event.
Dryad. https://doi.org/10.5061/dryad.2kb6fh4'
chicago: 'Barton, Nicholas H. “Data from: The Consequences of an Introgression Event.”
Dryad, 2019. https://doi.org/10.5061/dryad.2kb6fh4.'
ieee: 'N. H. Barton, “Data from: The consequences of an introgression event.” Dryad,
2019.'
ista: 'Barton NH. 2019. Data from: The consequences of an introgression event, Dryad,
10.5061/dryad.2kb6fh4.'
mla: 'Barton, Nicholas H. Data from: The Consequences of an Introgression Event.
Dryad, 2019, doi:10.5061/dryad.2kb6fh4.'
short: N.H. Barton, (2019).
date_created: 2021-08-06T12:03:50Z
date_published: 2019-01-09T00:00:00Z
date_updated: 2023-09-19T10:06:07Z
day: '09'
department:
- _id: NiBa
doi: 10.5061/dryad.2kb6fh4
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.2kb6fh4
month: '01'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '40'
relation: used_in_publication
status: public
status: public
title: 'Data from: The consequences of an introgression event'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2019'
...
---
_id: '6071'
abstract:
- lang: eng
text: 'Transcription factors, by binding to specific sequences on the DNA, control
the precise spatio-temporal expression of genes inside a cell. However, this specificity
is limited, leading to frequent incorrect binding of transcription factors that
might have deleterious consequences on the cell. By constructing a biophysical
model of TF-DNA binding in the context of gene regulation, I will first explore
how regulatory constraints can strongly shape the distribution of a population
in sequence space. Then, by directly linking this to a picture of multiple types
of transcription factors performing their functions simultaneously inside the
cell, I will explore the extent of regulatory crosstalk -- incorrect binding interactions
between transcription factors and binding sites that lead to erroneous regulatory
states -- and understand the constraints this places on the design of regulatory
systems. I will then develop a generic theoretical framework to investigate the
coevolution of multiple transcription factors and multiple binding sites, in the
context of a gene regulatory network that performs a certain function. As a particular
tractable version of this problem, I will consider the evolution of two transcription
factors when they transmit upstream signals to downstream target genes. Specifically,
I will describe the evolutionary steady states and the evolutionary pathways involved,
along with their timescales, of a system that initially undergoes a transcription
factor duplication event. To connect this important theoretical model to the prominent
biological event of transcription factor duplication giving rise to paralogous
families, I will then describe a bioinformatics analysis of C2H2 Zn-finger transcription
factors, a major family in humans, and focus on the patterns of evolution that
paralogs have undergone in their various protein domains in the recent past. '
alternative_title:
- ISTA Thesis
article_processing_charge: No
author:
- first_name: Roshan
full_name: Prizak, Roshan
id: 4456104E-F248-11E8-B48F-1D18A9856A87
last_name: Prizak
citation:
ama: Prizak R. Coevolution of transcription factors and their binding sites in sequence
space. 2019. doi:10.15479/at:ista:th6071
apa: Prizak, R. (2019). Coevolution of transcription factors and their binding
sites in sequence space. Institute of Science and Technology Austria. https://doi.org/10.15479/at:ista:th6071
chicago: Prizak, Roshan. “Coevolution of Transcription Factors and Their Binding
Sites in Sequence Space.” Institute of Science and Technology Austria, 2019. https://doi.org/10.15479/at:ista:th6071.
ieee: R. Prizak, “Coevolution of transcription factors and their binding sites in
sequence space,” Institute of Science and Technology Austria, 2019.
ista: Prizak R. 2019. Coevolution of transcription factors and their binding sites
in sequence space. Institute of Science and Technology Austria.
mla: Prizak, Roshan. Coevolution of Transcription Factors and Their Binding Sites
in Sequence Space. Institute of Science and Technology Austria, 2019, doi:10.15479/at:ista:th6071.
short: R. Prizak, Coevolution of Transcription Factors and Their Binding Sites in
Sequence Space, Institute of Science and Technology Austria, 2019.
date_created: 2019-03-06T16:16:10Z
date_published: 2019-03-11T00:00:00Z
date_updated: 2023-09-22T10:00:48Z
day: '11'
ddc:
- '576'
degree_awarded: PhD
department:
- _id: GaTk
- _id: NiBa
doi: 10.15479/at:ista:th6071
file:
- access_level: open_access
checksum: e60a72de35d270b31f1a23d50f224ec0
content_type: application/pdf
creator: rprizak
date_created: 2019-03-06T16:05:07Z
date_updated: 2020-07-14T12:47:18Z
file_id: '6072'
file_name: Thesis_final_PDFA_RoshanPrizak.pdf
file_size: 20995465
relation: main_file
- access_level: closed
checksum: 67c2630333d05ebafef5f018863a8465
content_type: application/zip
creator: rprizak
date_created: 2019-03-06T16:09:39Z
date_updated: 2020-07-14T12:47:18Z
file_id: '6073'
file_name: thesis_v2_merge.zip
file_size: 85705272
relation: source_file
title: Latex files
file_date_updated: 2020-07-14T12:47:18Z
has_accepted_license: '1'
language:
- iso: eng
month: '03'
oa: 1
oa_version: Published Version
page: '189'
project:
- _id: 254E9036-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P28844-B27
name: Biophysics of information processing in gene regulation
publication_identifier:
issn:
- 2663-337X
publication_status: published
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '1358'
relation: part_of_dissertation
status: public
- id: '955'
relation: part_of_dissertation
status: public
status: public
supervisor:
- first_name: Gašper
full_name: Tkačik, Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
title: Coevolution of transcription factors and their binding sites in sequence space
type: dissertation
user_id: c635000d-4b10-11ee-a964-aac5a93f6ac1
year: '2019'
...
---
_id: '6856'
abstract:
- lang: eng
text: 'Plant mating systems play a key role in structuring genetic variation both
within and between species. In hybrid zones, the outcomes and dynamics of hybridization
are usually interpreted as the balance between gene flow and selection against
hybrids. Yet, mating systems can introduce selective forces that alter these expectations;
with diverse outcomes for the level and direction of gene flow depending on variation
in outcrossing and whether the mating systems of the species pair are the same
or divergent. We present a survey of hybridization in 133 species pairs from 41
plant families and examine how patterns of hybridization vary with mating system.
We examine if hybrid zone mode, level of gene flow, asymmetries in gene flow and
the frequency of reproductive isolating barriers vary in relation to mating system/s
of the species pair. We combine these results with a simulation model and examples
from the literature to address two general themes: (i) the two‐way interaction
between introgression and the evolution of reproductive systems, and (ii) how
mating system can facilitate or restrict interspecific gene flow. We conclude
that examining mating system with hybridization provides unique opportunities
to understand divergence and the processes underlying reproductive isolation.'
article_processing_charge: No
article_type: original
author:
- first_name: Melinda
full_name: Pickup, Melinda
id: 2C78037E-F248-11E8-B48F-1D18A9856A87
last_name: Pickup
orcid: 0000-0001-6118-0541
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Yaniv
full_name: Brandvain, Yaniv
last_name: Brandvain
- first_name: Christelle
full_name: Fraisse, Christelle
id: 32DF5794-F248-11E8-B48F-1D18A9856A87
last_name: Fraisse
orcid: 0000-0001-8441-5075
- first_name: Sarah
full_name: Yakimowski, Sarah
last_name: Yakimowski
- first_name: Tanmay
full_name: Dixit, Tanmay
last_name: Dixit
- first_name: Christian
full_name: Lexer, Christian
last_name: Lexer
- first_name: Eva
full_name: Cereghetti, Eva
id: 71AA91B4-05ED-11EA-8BEB-F5833E63BD63
last_name: Cereghetti
- first_name: David
full_name: Field, David
id: 419049E2-F248-11E8-B48F-1D18A9856A87
last_name: Field
orcid: 0000-0002-4014-8478
citation:
ama: 'Pickup M, Barton NH, Brandvain Y, et al. Mating system variation in hybrid
zones: Facilitation, barriers and asymmetries to gene flow. New Phytologist.
2019;224(3):1035-1047. doi:10.1111/nph.16180'
apa: 'Pickup, M., Barton, N. H., Brandvain, Y., Fraisse, C., Yakimowski, S., Dixit,
T., … Field, D. (2019). Mating system variation in hybrid zones: Facilitation,
barriers and asymmetries to gene flow. New Phytologist. Wiley. https://doi.org/10.1111/nph.16180'
chicago: 'Pickup, Melinda, Nicholas H Barton, Yaniv Brandvain, Christelle Fraisse,
Sarah Yakimowski, Tanmay Dixit, Christian Lexer, Eva Cereghetti, and David Field.
“Mating System Variation in Hybrid Zones: Facilitation, Barriers and Asymmetries
to Gene Flow.” New Phytologist. Wiley, 2019. https://doi.org/10.1111/nph.16180.'
ieee: 'M. Pickup et al., “Mating system variation in hybrid zones: Facilitation,
barriers and asymmetries to gene flow,” New Phytologist, vol. 224, no.
3. Wiley, pp. 1035–1047, 2019.'
ista: 'Pickup M, Barton NH, Brandvain Y, Fraisse C, Yakimowski S, Dixit T, Lexer
C, Cereghetti E, Field D. 2019. Mating system variation in hybrid zones: Facilitation,
barriers and asymmetries to gene flow. New Phytologist. 224(3), 1035–1047.'
mla: 'Pickup, Melinda, et al. “Mating System Variation in Hybrid Zones: Facilitation,
Barriers and Asymmetries to Gene Flow.” New Phytologist, vol. 224, no.
3, Wiley, 2019, pp. 1035–47, doi:10.1111/nph.16180.'
short: M. Pickup, N.H. Barton, Y. Brandvain, C. Fraisse, S. Yakimowski, T. Dixit,
C. Lexer, E. Cereghetti, D. Field, New Phytologist 224 (2019) 1035–1047.
date_created: 2019-09-07T14:35:40Z
date_published: 2019-11-01T00:00:00Z
date_updated: 2023-10-18T08:47:08Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1111/nph.16180
ec_funded: 1
external_id:
pmid:
- '31505037'
file:
- access_level: open_access
checksum: 21e4c95599bbcaf7c483b89954658672
content_type: application/pdf
creator: dernst
date_created: 2019-11-13T08:15:05Z
date_updated: 2020-07-14T12:47:42Z
file_id: '7011'
file_name: 2019_NewPhytologist_Pickup.pdf
file_size: 1511958
relation: main_file
file_date_updated: 2020-07-14T12:47:42Z
has_accepted_license: '1'
intvolume: ' 224'
issue: '3'
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
page: 1035-1047
pmid: 1
project:
- _id: 25B36484-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '329960'
name: Mating system and the evolutionary dynamics of hybrid zones
- _id: 2662AADE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02463
name: Sex chromosomes and species barriers
publication: New Phytologist
publication_identifier:
eissn:
- 1469-8137
issn:
- 0028-646X
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Mating system variation in hybrid zones: Facilitation, barriers and asymmetries
to gene flow'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 224
year: '2019'
...
---
_id: '6089'
abstract:
- lang: eng
text: Pleiotropy is the well-established idea that a single mutation affects multiple
phenotypes. If a mutation has opposite effects on fitness when expressed in different
contexts, then genetic conflict arises. Pleiotropic conflict is expected to reduce
the efficacy of selection by limiting the fixation of beneficial mutations through
adaptation, and the removal of deleterious mutations through purifying selection.
Although this has been widely discussed, in particular in the context of a putative
“gender load,” it has yet to be systematically quantified. In this work, we empirically
estimate to which extent different pleiotropic regimes impede the efficacy of
selection in Drosophila melanogaster. We use whole-genome polymorphism data from
a single African population and divergence data from D. simulans to estimate the
fraction of adaptive fixations (α), the rate of adaptation (ωA), and the direction
of selection (DoS). After controlling for confounding covariates, we find that
the different pleiotropic regimes have a relatively small, but significant, effect
on selection efficacy. Specifically, our results suggest that pleiotropic sexual
antagonism may restrict the efficacy of selection, but that this conflict can
be resolved by limiting the expression of genes to the sex where they are beneficial.
Intermediate levels of pleiotropy across tissues and life stages can also lead
to maladaptation in D. melanogaster, due to inefficient purifying selection combined
with low frequency of mutations that confer a selective advantage. Thus, our study
highlights the need to consider the efficacy of selection in the context of antagonistic
pleiotropy, and of genetic conflict in general.
article_processing_charge: No
author:
- first_name: Christelle
full_name: Fraisse, Christelle
id: 32DF5794-F248-11E8-B48F-1D18A9856A87
last_name: Fraisse
orcid: 0000-0001-8441-5075
- first_name: Gemma
full_name: Puixeu Sala, Gemma
id: 33AB266C-F248-11E8-B48F-1D18A9856A87
last_name: Puixeu Sala
orcid: 0000-0001-8330-1754
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
citation:
ama: Fraisse C, Puixeu Sala G, Vicoso B. Pleiotropy modulates the efficacy of selection
in drosophila melanogaster. Molecular biology and evolution. 2019;36(3):500-515.
doi:10.1093/molbev/msy246
apa: Fraisse, C., Puixeu Sala, G., & Vicoso, B. (2019). Pleiotropy modulates
the efficacy of selection in drosophila melanogaster. Molecular Biology and
Evolution. Oxford University Press. https://doi.org/10.1093/molbev/msy246
chicago: Fraisse, Christelle, Gemma Puixeu Sala, and Beatriz Vicoso. “Pleiotropy
Modulates the Efficacy of Selection in Drosophila Melanogaster.” Molecular
Biology and Evolution. Oxford University Press, 2019. https://doi.org/10.1093/molbev/msy246.
ieee: C. Fraisse, G. Puixeu Sala, and B. Vicoso, “Pleiotropy modulates the efficacy
of selection in drosophila melanogaster,” Molecular biology and evolution,
vol. 36, no. 3. Oxford University Press, pp. 500–515, 2019.
ista: Fraisse C, Puixeu Sala G, Vicoso B. 2019. Pleiotropy modulates the efficacy
of selection in drosophila melanogaster. Molecular biology and evolution. 36(3),
500–515.
mla: Fraisse, Christelle, et al. “Pleiotropy Modulates the Efficacy of Selection
in Drosophila Melanogaster.” Molecular Biology and Evolution, vol. 36,
no. 3, Oxford University Press, 2019, pp. 500–15, doi:10.1093/molbev/msy246.
short: C. Fraisse, G. Puixeu Sala, B. Vicoso, Molecular Biology and Evolution 36
(2019) 500–515.
date_created: 2019-03-10T22:59:19Z
date_published: 2019-03-01T00:00:00Z
date_updated: 2024-02-21T13:59:17Z
day: '01'
department:
- _id: BeVi
- _id: NiBa
doi: 10.1093/molbev/msy246
external_id:
isi:
- '000462585100006'
pmid:
- '30590559'
intvolume: ' 36'
isi: 1
issue: '3'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.ncbi.nlm.nih.gov/pubmed/30590559
month: '03'
oa: 1
oa_version: Submitted Version
page: 500-515
pmid: 1
project:
- _id: 250ED89C-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: P28842-B22
name: Sex chromosome evolution under male- and female- heterogamety
publication: Molecular biology and evolution
publication_identifier:
eissn:
- 1537-1719
issn:
- 0737-4038
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
related_material:
record:
- id: '5757'
relation: popular_science
status: public
scopus_import: '1'
status: public
title: Pleiotropy modulates the efficacy of selection in drosophila melanogaster
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 36
year: '2019'
...
---
_id: '6090'
abstract:
- lang: eng
text: Cells need to reliably sense external ligand concentrations to achieve various
biological functions such as chemotaxis or signaling. The molecular recognition
of ligands by surface receptors is degenerate in many systems, leading to crosstalk
between ligand-receptor pairs. Crosstalk is often thought of as a deviation from
optimal specific recognition, as the binding of noncognate ligands can interfere
with the detection of the receptor's cognate ligand, possibly leading to a false
triggering of a downstream signaling pathway. Here we quantify the optimal precision
of sensing the concentrations of multiple ligands by a collection of promiscuous
receptors. We demonstrate that crosstalk can improve precision in concentration
sensing and discrimination tasks. To achieve superior precision, the additional
information about ligand concentrations contained in short binding events of the
noncognate ligand should be exploited. We present a proofreading scheme to realize
an approximate estimation of multiple ligand concentrations that reaches a precision
close to the derived optimal bounds. Our results help rationalize the observed
ubiquity of receptor crosstalk in molecular sensing.
article_number: '022423'
article_processing_charge: No
author:
- first_name: Martín
full_name: Carballo-Pacheco, Martín
last_name: Carballo-Pacheco
- first_name: Jonathan
full_name: Desponds, Jonathan
last_name: Desponds
- first_name: Tatyana
full_name: Gavrilchenko, Tatyana
last_name: Gavrilchenko
- first_name: Andreas
full_name: Mayer, Andreas
last_name: Mayer
- first_name: Roshan
full_name: Prizak, Roshan
id: 4456104E-F248-11E8-B48F-1D18A9856A87
last_name: Prizak
- first_name: Gautam
full_name: Reddy, Gautam
last_name: Reddy
- first_name: Ilya
full_name: Nemenman, Ilya
last_name: Nemenman
- first_name: Thierry
full_name: Mora, Thierry
last_name: Mora
citation:
ama: Carballo-Pacheco M, Desponds J, Gavrilchenko T, et al. Receptor crosstalk improves
concentration sensing of multiple ligands. Physical Review E. 2019;99(2).
doi:10.1103/PhysRevE.99.022423
apa: Carballo-Pacheco, M., Desponds, J., Gavrilchenko, T., Mayer, A., Prizak, R.,
Reddy, G., … Mora, T. (2019). Receptor crosstalk improves concentration sensing
of multiple ligands. Physical Review E. American Physical Society. https://doi.org/10.1103/PhysRevE.99.022423
chicago: Carballo-Pacheco, Martín, Jonathan Desponds, Tatyana Gavrilchenko, Andreas
Mayer, Roshan Prizak, Gautam Reddy, Ilya Nemenman, and Thierry Mora. “Receptor
Crosstalk Improves Concentration Sensing of Multiple Ligands.” Physical Review
E. American Physical Society, 2019. https://doi.org/10.1103/PhysRevE.99.022423.
ieee: M. Carballo-Pacheco et al., “Receptor crosstalk improves concentration
sensing of multiple ligands,” Physical Review E, vol. 99, no. 2. American
Physical Society, 2019.
ista: Carballo-Pacheco M, Desponds J, Gavrilchenko T, Mayer A, Prizak R, Reddy G,
Nemenman I, Mora T. 2019. Receptor crosstalk improves concentration sensing of
multiple ligands. Physical Review E. 99(2), 022423.
mla: Carballo-Pacheco, Martín, et al. “Receptor Crosstalk Improves Concentration
Sensing of Multiple Ligands.” Physical Review E, vol. 99, no. 2, 022423,
American Physical Society, 2019, doi:10.1103/PhysRevE.99.022423.
short: M. Carballo-Pacheco, J. Desponds, T. Gavrilchenko, A. Mayer, R. Prizak, G.
Reddy, I. Nemenman, T. Mora, Physical Review E 99 (2019).
date_created: 2019-03-10T22:59:20Z
date_published: 2019-02-26T00:00:00Z
date_updated: 2024-02-28T13:12:06Z
day: '26'
department:
- _id: NiBa
- _id: GaTk
doi: 10.1103/PhysRevE.99.022423
external_id:
isi:
- '000459916500007'
intvolume: ' 99'
isi: 1
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://www.biorxiv.org/content/10.1101/448118v1.abstract
month: '02'
oa: 1
oa_version: Preprint
publication: Physical Review E
publication_status: published
publisher: American Physical Society
quality_controlled: '1'
scopus_import: '1'
status: public
title: Receptor crosstalk improves concentration sensing of multiple ligands
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 99
year: '2019'
...