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23 Publications

2020 | Journal Article | IST-REx-ID: 7788 | OA
M. J. W. Adjobo-Hermans et al., “NDUFS4 deletion triggers loss of NDUFA12 in Ndufs4−/− mice and Leigh syndrome patients: A stabilizing role for NDUFAF2,” Biochimica et Biophysica Acta - Bioenergetics, vol. 1861, no. 8, 2020.
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2020 | Journal Article | IST-REx-ID: 8040
C. Gupta et al., “Charge transfer and chemo-mechanical coupling in respiratory complex I,” Journal of the American Chemical Society, vol. 142, no. 20, pp. 9220–9230, 2020.
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2020 | Journal Article | IST-REx-ID: 8284 | OA
J. Steiner and L. A. Sazanov, “Structure and mechanism of the Mrp complex, an ancient cation/proton antiporter,” eLife, vol. 9, 2020.
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2020 | Journal Article | IST-REx-ID: 8318 | OA
J. Gutierrez-Fernandez et al., “Key role of quinone in the mechanism of respiratory complex I,” Nature Communications, vol. 11, no. 1, 2020.
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2020 | Thesis | IST-REx-ID: 8340
D. Kampjut, Molecular mechanisms of mitochondrial redox-coupled proton pumping enzymes. IST Austria, 2020.
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2020 | Thesis | IST-REx-ID: 8353
J. Steiner, Biochemical and structural investigation of the Mrp antiporter, an ancestor of complex I. IST Austria, 2020.
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2019 | Journal Article | IST-REx-ID: 7395 | OA
J. A. Letts, K. Fiedorczuk, G. Degliesposti, M. Skehel, and L. A. Sazanov, “Structures of respiratory supercomplex I+III2 reveal functional and conformational crosstalk,” Molecular Cell, vol. 75, no. 6, p. 1131–1146.e6, 2019.
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2019 | Journal Article | IST-REx-ID: 6352 | OA
A. A. Temnov et al., “Protective properties of the cultured stem cell proteome studied in an animal model of acetaminophen-induced acute liver failure,” Molecular Biology Reports, 2019.
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2019 | Journal Article | IST-REx-ID: 6848
D. Kampjut and L. A. Sazanov, “Structure and mechanism of mitochondrial proton-translocating transhydrogenase,” Nature, vol. 573, no. 7773, pp. 291–295, 2019.
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2019 | Journal Article | IST-REx-ID: 6859
L. Zhou and L. A. Sazanov, “Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase,” Science, vol. 365, no. 6455, 2019.
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2019 | Journal Article | IST-REx-ID: 6919 | OA
C. Qi, G. D. Minin, I. Vercellino, A. Wutz, and V. M. Korkhov, “Structural basis of sterol recognition by human hedgehog receptor PTCH1,” Science Advances, vol. 5, no. 9, 2019.
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2018 | Journal Article | IST-REx-ID: 152 | OA
K. Fiedorczuk and L. A. Sazanov, “Mammalian mitochondrial complex I structure and disease causing mutations,” Trends in Cell Biology, vol. 28, no. 10, pp. 835–867, 2018.
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2017 | Book Chapter | IST-REx-ID: 444
L. A. Sazanov, “Structure of respiratory complex I: ‘Minimal’ bacterial and ‘de luxe’ mammalian versions,” in Mechanisms of primary energy transduction in biology , M. Wikström, Ed. Royal Society of Chemistry, 2017, pp. 25–59.
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2017 | Journal Article | IST-REx-ID: 515 | OA
J. A. Letts and L. A. Sazanov, “Clarifying the supercomplex: The higher-order organization of the mitochondrial electron transport chain,” Nature Structural and Molecular Biology, vol. 24, no. 10, pp. 800–808, 2017.
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2016 | Journal Article | IST-REx-ID: 1186 | OA
J. Gutierrez-Fernandez et al., “Modular architecture and unique teichoic acid recognition features of choline-binding protein L CbpL contributing to pneumococcal pathogenesis,” Scientific Reports, vol. 6, 2016.
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2016 | Journal Article | IST-REx-ID: 1209 | OA
J. A. Letts, G. Degliesposti, K. Fiedorczuk, M. Skehel, and L. A. Sazanov, “Purification of ovine respiratory complex i results in a highly active and stable preparation,” Journal of Biological Chemistry, vol. 291, no. 47, pp. 24657–24675, 2016.
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2016 | Journal Article | IST-REx-ID: 1226 | OA
K. Fiedorczuk, J. A. Letts, G. Degliesposti, K. Kaszuba, M. Skehel, and L. A. Sazanov, “Atomic structure of the entire mammalian mitochondrial complex i,” Nature, vol. 538, no. 7625, pp. 406–410, 2016.
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2016 | Journal Article | IST-REx-ID: 1232
J. A. Letts, K. Fiedorczuk, and L. A. Sazanov, “The architecture of respiratory supercomplexes,” Nature, vol. 537, no. 7622, pp. 644–648, 2016.
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2016 | Journal Article | IST-REx-ID: 1276 | OA
P. Postila et al., “Atomistic determinants of co-enzyme Q reduction at the Qi-site of the cytochrome bc1 complex,” Scientific Reports, vol. 6, 2016.
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2016 | Journal Article | IST-REx-ID: 1288
P. Holt, R. Efremov, E. Nakamaru Ogiso, and L. A. Sazanov, “Reversible FMN dissociation from Escherichia coli respiratory complex I,” Biochimica et Biophysica Acta - Bioenergetics, vol. 1857, no. 11, pp. 1777–1785, 2016.
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2016 | Journal Article | IST-REx-ID: 1521
J. Berrisford, R. Baradaran, and L. A. Sazanov, “Structure of bacterial respiratory complex I,” Biochimica et Biophysica Acta - Bioenergetics, vol. 1857, no. 7, pp. 892–901, 2016.
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2015 | Journal Article | IST-REx-ID: 1638
L. A. Sazanov, “A giant molecular proton pump: structure and mechanism of respiratory complex I,” Nature Reviews Molecular Cell Biology, vol. 16, no. 6, pp. 375–388, 2015.
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2015 | Journal Article | IST-REx-ID: 1683
J. A. Letts and L. A. Sazanov, “Gaining mass: The structure of respiratory complex I-from bacterial towards mitochondrial versions,” Current Opinion in Structural Biology, vol. 33, no. 8, pp. 135–145, 2015.
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