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53 Publications

2018 | Journal Article | IST-REx-ID: 152
Mammalian mitochondrial complex I structure and disease causing mutations
K. Fiedorczuk, L.A. Sazanov, Trends in Cell Biology 28 (2018) 835–867.
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2017 | Journal Article | IST-REx-ID: 443   OA
Mitochondrial mutations and metabolic adaptation in pancreatic cancer
R. Hardie, E. Van Dam, M. Cowley, T. Han, S. Balaban, M. Pajic, M. Pinese, M. Iconomou, R. Shearer, J. Mckenna, D. Miller, N. Waddell, J. Pearson, S. Grimmond, L.A. Sazanov, A. Biankin, S. Villas Boas, A. Hoy, N. Turner, D. Saunders, Cancer & Metabolism 5 (2017).
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2017 | Book Chapter | IST-REx-ID: 444
Structure of respiratory complex I: “Minimal” bacterial and “de luxe” mammalian versions
L.A. Sazanov, in:, M. Wikström (Ed.), Mechanisms of Primary Energy Transduction in Biology , Royal Society of Chemistry, 2017, pp. 25–59.
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2017 | Journal Article | IST-REx-ID: 515
Clarifying the supercomplex: The higher-order organization of the mitochondrial electron transport chain
J.A. Letts, L.A. Sazanov, Nature Structural and Molecular Biology 24 (2017) 800–808.
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2016 | Journal Article | IST-REx-ID: 1232
The architecture of respiratory supercomplexes
J.A. Letts, K. Fiedorczuk, L.A. Sazanov, Nature 537 (2016) 644–648.
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2016 | Journal Article | IST-REx-ID: 1186   OA
Modular architecture and unique teichoic acid recognition features of choline-binding protein L CbpL contributing to pneumococcal pathogenesis
J. Gutierrez-Fernandez, M. Saleh, M. Alcorlo, A. Gómez Mejóa, D. Pantoja Uceda, M. Treviño, F. Vob, M. Abdullah, S. Galán Bartual, J. Seinen, P. Sánchez Murcia, F. Gago, M. Bruix, S. Hammerschmidt, J. Hermoso, Scientific Reports 6 (2016).
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2016 | Journal Article | IST-REx-ID: 1276   OA
Atomistic determinants of co-enzyme Q reduction at the Qi-site of the cytochrome bc1 complex
P. Postila, K. Kaszuba, P. Kuleta, I. Vattulainen, M. Sarewicz, A. Osyczka, T. Róg, Scientific Reports 6 (2016).
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2016 | Journal Article | IST-REx-ID: 1288
Reversible FMN dissociation from Escherichia coli respiratory complex I
P. Holt, R. Efremov, E. Nakamaru Ogiso, L.A. Sazanov, Biochimica et Biophysica Acta - Bioenergetics 1857 (2016) 1777–1785.
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2016 | Journal Article | IST-REx-ID: 1226
Atomic structure of the entire mammalian mitochondrial complex i
K. Fiedorczuk, J.A. Letts, G. Degliesposti, K. Kaszuba, M. Skehel, L.A. Sazanov, Nature 538 (2016) 406–410.
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2016 | Journal Article | IST-REx-ID: 1209   OA
Purification of ovine respiratory complex i results in a highly active and stable preparation
J.A. Letts, G. Degliesposti, K. Fiedorczuk, M. Skehel, L.A. Sazanov, Journal of Biological Chemistry 291 (2016) 24657–24675.
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2016 | Journal Article | IST-REx-ID: 1521
Structure of bacterial respiratory complex I
J. Berrisford, R. Baradaran, L.A. Sazanov, Biochimica et Biophysica Acta - Bioenergetics 1857 (2016) 892–901.
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2015 | Journal Article | IST-REx-ID: 1683
Gaining mass: The structure of respiratory complex I-from bacterial towards mitochondrial versions
J.A. Letts, L.A. Sazanov, Current Opinion in Structural Biology 33 (2015) 135–145.
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2015 | Journal Article | IST-REx-ID: 1638
A giant molecular proton pump: structure and mechanism of respiratory complex I
L.A. Sazanov, Nature Reviews Molecular Cell Biology 16 (2015) 375–388.
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2014 | Journal Article | IST-REx-ID: 1980
Structure of the bacterial type II NADH dehydrogenase: a monotopic membrane protein with an essential role in energy generation
A. Heikal, Y. Nakatani, E. Dunn, M. Weimar, C. Day, E. Baker, S. Lott, L.A. Sazanov, G. Cook, Molecular Microbiology 91 (2014) 950–964.
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2014 | Journal Article | IST-REx-ID: 1979
The mechanism of coupling between electron transfer and proton translocation in respiratory complex I
L.A. Sazanov, Journal of Bioenergetics and Biomembranes 46 (2014) 247–253.
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2014 | Book Review | IST-REx-ID: 1981
Review and meta-analysis of natural selection in mitochondrial complex I in metazoans
M. Garvin, J. Bielawski, L.A. Sazanov, A. Gharrett, Journal of Zoological Systematics and Evolutionary Research 53 (2014) 1–17.
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2013 | Journal Article | IST-REx-ID: 1977
A long road towards the structure of respiratory complex I, a giant molecular proton pump
L.A. Sazanov, R. Baradaran, R. Efremov, J. Berrisford, G. Minhas, Biochemical Society Transactions 41 (2013) 1265–1271.
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2013 | Journal Article | IST-REx-ID: 1978
Crystal structure of the entire respiratory complex i
R. Baradaran, J. Berrisford, G. Minhas, L.A. Sazanov, Nature 494 (2013) 443–448.
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2012 | Book Review | IST-REx-ID: 1976
The coupling mechanism of respiratory complex i - A structural and evolutionary perspective
R. Efremov, L.A. Sazanov, Biochimica et Biophysica Acta - Bioenergetics 1817 (2012) 1785–1795.
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2012 | Journal Article | IST-REx-ID: 1972
Structure of Escherichia coli OmpF porin from lipidic mesophase
R. Efremov, L.A. Sazanov, Journal of Structural Biology 178 (2012) 311–318.
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