---
_id: '8930'
abstract:
- lang: eng
text: Phenomenological relations such as Ohm’s or Fourier’s law have a venerable
history in physics but are still scarce in biology. This situation restrains predictive
theory. Here, we build on bacterial “growth laws,” which capture physiological
feedback between translation and cell growth, to construct a minimal biophysical
model for the combined action of ribosome-targeting antibiotics. Our model predicts
drug interactions like antagonism or synergy solely from responses to individual
drugs. We provide analytical results for limiting cases, which agree well with
numerical results. We systematically refine the model by including direct physical
interactions of different antibiotics on the ribosome. In a limiting case, our
model provides a mechanistic underpinning for recent predictions of higher-order
interactions that were derived using entropy maximization. We further refine the
model to include the effects of antibiotics that mimic starvation and the presence
of resistance genes. We describe the impact of a starvation-mimicking antibiotic
on drug interactions analytically and verify it experimentally. Our extended model
suggests a change in the type of drug interaction that depends on the strength
of resistance, which challenges established rescaling paradigms. We experimentally
show that the presence of unregulated resistance genes can lead to altered drug
interaction, which agrees with the prediction of the model. While minimal, the
model is readily adaptable and opens the door to predicting interactions of second
and higher-order in a broad range of biological systems.
article_processing_charge: No
author:
- first_name: Bor
full_name: Kavcic, Bor
id: 350F91D2-F248-11E8-B48F-1D18A9856A87
last_name: Kavcic
orcid: 0000-0001-6041-254X
citation:
ama: Kavcic B. Analysis scripts and research data for the paper “Minimal biophysical
model of combined antibiotic action.” 2020. doi:10.15479/AT:ISTA:8930
apa: Kavcic, B. (2020). Analysis scripts and research data for the paper “Minimal
biophysical model of combined antibiotic action.” Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:8930
chicago: Kavcic, Bor. “Analysis Scripts and Research Data for the Paper ‘Minimal
Biophysical Model of Combined Antibiotic Action.’” Institute of Science and Technology
Austria, 2020. https://doi.org/10.15479/AT:ISTA:8930.
ieee: B. Kavcic, “Analysis scripts and research data for the paper ‘Minimal biophysical
model of combined antibiotic action.’” Institute of Science and Technology Austria,
2020.
ista: Kavcic B. 2020. Analysis scripts and research data for the paper ‘Minimal
biophysical model of combined antibiotic action’, Institute of Science and Technology
Austria, 10.15479/AT:ISTA:8930.
mla: Kavcic, Bor. Analysis Scripts and Research Data for the Paper “Minimal Biophysical
Model of Combined Antibiotic Action.” Institute of Science and Technology
Austria, 2020, doi:10.15479/AT:ISTA:8930.
short: B. Kavcic, (2020).
contributor:
- contributor_type: supervisor
first_name: Gašper
id: 3D494DCA-F248-11E8-B48F-1D18A9856A87
last_name: Tkačik
orcid: 0000-0002-6699-1455
- contributor_type: supervisor
first_name: Tobias
id: 3E6DB97A-F248-11E8-B48F-1D18A9856A87
last_name: Bollenbach
date_created: 2020-12-09T15:04:02Z
date_published: 2020-12-10T00:00:00Z
date_updated: 2024-02-21T12:41:42Z
day: '10'
ddc:
- '570'
department:
- _id: GaTk
doi: 10.15479/AT:ISTA:8930
file:
- access_level: open_access
checksum: 60a818edeffaa7da1ebf5f8fbea9ba18
content_type: application/zip
creator: bkavcic
date_created: 2020-12-09T15:00:19Z
date_updated: 2020-12-09T15:00:19Z
file_id: '8932'
file_name: PLoSCompBiol2020_datarep.zip
file_size: 315494370
relation: main_file
success: 1
file_date_updated: 2020-12-09T15:00:19Z
has_accepted_license: '1'
keyword:
- Escherichia coli
- antibiotic combinations
- translation
- growth laws
- drug interactions
- bacterial physiology
- translation inhibitors
license: https://creativecommons.org/licenses/by/4.0/
month: '12'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8997'
relation: used_in_publication
status: public
status: public
title: Analysis scripts and research data for the paper "Minimal biophysical model
of combined antibiotic action"
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8951'
abstract:
- lang: eng
text: Gene expression levels are influenced by multiple coexisting molecular mechanisms.
Some of these interactions, such as those of transcription factors and promoters
have been studied extensively. However, predicting phenotypes of gene regulatory
networks remains a major challenge. Here, we use a well-defined synthetic gene
regulatory network to study how network phenotypes depend on local genetic context,
i.e. the genetic neighborhood of a transcription factor and its relative position.
We show that one gene regulatory network with fixed topology can display not only
quantitatively but also qualitatively different phenotypes, depending solely on
the local genetic context of its components. Our results demonstrate that changes
in local genetic context can place a single transcriptional unit within two separate
regulons without the need for complex regulatory sequences. We propose that relative
order of individual transcriptional units, with its potential for combinatorial
complexity, plays an important role in shaping phenotypes of gene regulatory networks.
article_processing_charge: No
author:
- first_name: Anna A
full_name: Nagy-Staron, Anna A
id: 3ABC5BA6-F248-11E8-B48F-1D18A9856A87
last_name: Nagy-Staron
orcid: 0000-0002-1391-8377
citation:
ama: Nagy-Staron AA. Sequences of gene regulatory network permutations for the article
“Local genetic context shapes the function of a gene regulatory network.” 2020.
doi:10.15479/AT:ISTA:8951
apa: Nagy-Staron, A. A. (2020). Sequences of gene regulatory network permutations
for the article “Local genetic context shapes the function of a gene regulatory
network.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8951
chicago: Nagy-Staron, Anna A. “Sequences of Gene Regulatory Network Permutations
for the Article ‘Local Genetic Context Shapes the Function of a Gene Regulatory
Network.’” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8951.
ieee: A. A. Nagy-Staron, “Sequences of gene regulatory network permutations for
the article ‘Local genetic context shapes the function of a gene regulatory network.’”
Institute of Science and Technology Austria, 2020.
ista: Nagy-Staron AA. 2020. Sequences of gene regulatory network permutations for
the article ‘Local genetic context shapes the function of a gene regulatory network’,
Institute of Science and Technology Austria, 10.15479/AT:ISTA:8951.
mla: Nagy-Staron, Anna A. Sequences of Gene Regulatory Network Permutations for
the Article “Local Genetic Context Shapes the Function of a Gene Regulatory Network.”
Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8951.
short: A.A. Nagy-Staron, (2020).
contributor:
- contributor_type: project_member
first_name: Anna A
id: 3ABC5BA6-F248-11E8-B48F-1D18A9856A87
last_name: Nagy-Staron
- contributor_type: project_member
first_name: Kathrin
id: 3AEC8556-F248-11E8-B48F-1D18A9856A87
last_name: Tomasek
- contributor_type: project_member
first_name: Caroline
last_name: Caruso Carter
- contributor_type: project_member
first_name: Elisabeth
last_name: Sonnleitner
- contributor_type: project_member
first_name: Bor
id: 350F91D2-F248-11E8-B48F-1D18A9856A87
last_name: Kavcic
orcid: 0000-0001-6041-254X
- contributor_type: project_member
first_name: Tiago
last_name: Paixão
- contributor_type: project_manager
first_name: Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
date_created: 2020-12-20T10:00:26Z
date_published: 2020-12-21T00:00:00Z
date_updated: 2024-02-21T12:41:57Z
day: '21'
ddc:
- '570'
department:
- _id: CaGu
doi: 10.15479/AT:ISTA:8951
file:
- access_level: open_access
checksum: f57862aeee1690c7effd2b1117d40ed1
content_type: text/plain
creator: bkavcic
date_created: 2020-12-20T09:52:52Z
date_updated: 2020-12-20T09:52:52Z
file_id: '8952'
file_name: readme.txt
file_size: 523
relation: main_file
success: 1
- access_level: open_access
checksum: f2c6d5232ec6d551b6993991e8689e9f
content_type: application/octet-stream
creator: bkavcic
date_created: 2020-12-20T22:01:44Z
date_updated: 2020-12-20T22:01:44Z
file_id: '8954'
file_name: GRNs Research depository.gb
file_size: 379228
relation: main_file
success: 1
file_date_updated: 2020-12-20T22:01:44Z
has_accepted_license: '1'
keyword:
- Gene regulatory networks
- Gene expression
- Escherichia coli
- Synthetic Biology
month: '12'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '9283'
relation: used_in_publication
status: public
status: public
title: Sequences of gene regulatory network permutations for the article "Local genetic
context shapes the function of a gene regulatory network"
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '7383'
abstract:
- lang: eng
text: Organisms cope with change by employing transcriptional regulators. However,
when faced with rare environments, the evolution of transcriptional regulators
and their promoters may be too slow. We ask whether the intrinsic instability
of gene duplication and amplification provides a generic alternative to canonical
gene regulation. By real-time monitoring of gene copy number mutations in E. coli,
we show that gene duplications and amplifications enable adaptation to fluctuating
environments by rapidly generating copy number, and hence expression level, polymorphism.
This ‘amplification-mediated gene expression tuning’ occurs on timescales similar
to canonical gene regulation and can deal with rapid environmental changes. Mathematical
modeling shows that amplifications also tune gene expression in stochastic environments
where transcription factor-based schemes are hard to evolve or maintain. The fleeting
nature of gene amplifications gives rise to a generic population-level mechanism
that relies on genetic heterogeneity to rapidly tune expression of any gene, without
leaving any genomic signature.
article_processing_charge: No
author:
- first_name: Rok
full_name: Grah, Rok
id: 483E70DE-F248-11E8-B48F-1D18A9856A87
last_name: Grah
orcid: 0000-0003-2539-3560
citation:
ama: 'Grah R. Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level
Gene Expression regulation. 2020. doi:10.15479/AT:ISTA:7383'
apa: 'Grah, R. (2020). Matlab scripts for the Paper: Gene Amplification as a Form
of Population-Level Gene Expression regulation. Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:7383'
chicago: 'Grah, Rok. “Matlab Scripts for the Paper: Gene Amplification as a Form
of Population-Level Gene Expression Regulation.” Institute of Science and Technology
Austria, 2020. https://doi.org/10.15479/AT:ISTA:7383.'
ieee: 'R. Grah, “Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level
Gene Expression regulation.” Institute of Science and Technology Austria, 2020.'
ista: 'Grah R. 2020. Matlab scripts for the Paper: Gene Amplification as a Form
of Population-Level Gene Expression regulation, Institute of Science and Technology
Austria, 10.15479/AT:ISTA:7383.'
mla: 'Grah, Rok. Matlab Scripts for the Paper: Gene Amplification as a Form of
Population-Level Gene Expression Regulation. Institute of Science and Technology
Austria, 2020, doi:10.15479/AT:ISTA:7383.'
short: R. Grah, (2020).
contributor:
- contributor_type: project_leader
first_name: Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
date_created: 2020-01-28T10:41:49Z
date_published: 2020-01-28T00:00:00Z
date_updated: 2024-02-21T12:42:31Z
day: '28'
department:
- _id: CaGu
- _id: GaTk
doi: 10.15479/AT:ISTA:7383
file:
- access_level: open_access
checksum: 9d292cf5207b3829225f44c044cdb3fd
content_type: application/zip
creator: rgrah
date_created: 2020-01-28T10:39:40Z
date_updated: 2020-07-14T12:47:57Z
file_id: '7384'
file_name: Scripts.zip
file_size: 73363365
relation: main_file
- access_level: open_access
checksum: 4076ceab32ef588cc233802bab24c1ab
content_type: text/plain
creator: rgrah
date_created: 2020-01-28T10:39:30Z
date_updated: 2020-07-14T12:47:57Z
file_id: '7385'
file_name: READ_ME_MAIN.txt
file_size: 962
relation: main_file
file_date_updated: 2020-07-14T12:47:57Z
has_accepted_license: '1'
keyword:
- Matlab scripts
- analysis of microfluidics
- mathematical model
month: '01'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '7652'
relation: used_in_publication
status: public
status: public
title: 'Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level
Gene Expression regulation'
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '9222'
article_processing_charge: No
author:
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
citation:
ama: 'Katsaros G. Transport data for: Site‐controlled uniform Ge/Si Hut wires with
electrically tunable spin–orbit coupling. 2020. doi:10.15479/AT:ISTA:9222'
apa: 'Katsaros, G. (2020). Transport data for: Site‐controlled uniform Ge/Si Hut
wires with electrically tunable spin–orbit coupling. Institute of Science and
Technology Austria. https://doi.org/10.15479/AT:ISTA:9222'
chicago: 'Katsaros, Georgios. “Transport Data for: Site‐controlled Uniform Ge/Si
Hut Wires with Electrically Tunable Spin–Orbit Coupling.” Institute of Science
and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:9222.'
ieee: 'G. Katsaros, “Transport data for: Site‐controlled uniform Ge/Si Hut wires
with electrically tunable spin–orbit coupling.” Institute of Science and Technology
Austria, 2020.'
ista: 'Katsaros G. 2020. Transport data for: Site‐controlled uniform Ge/Si Hut wires
with electrically tunable spin–orbit coupling, Institute of Science and Technology
Austria, 10.15479/AT:ISTA:9222.'
mla: 'Katsaros, Georgios. Transport Data for: Site‐controlled Uniform Ge/Si Hut
Wires with Electrically Tunable Spin–Orbit Coupling. Institute of Science
and Technology Austria, 2020, doi:10.15479/AT:ISTA:9222.'
short: G. Katsaros, (2020).
contributor:
- contributor_type: research_group
first_name: Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
date_created: 2021-03-05T18:00:47Z
date_published: 2020-03-16T00:00:00Z
date_updated: 2024-02-21T12:42:13Z
day: '16'
ddc:
- '530'
department:
- _id: GeKa
doi: 10.15479/AT:ISTA:9222
file:
- access_level: open_access
checksum: 41b66e195ed3dbd73077feee77b05652
content_type: application/x-zip-compressed
creator: gkatsaro
date_created: 2021-03-05T17:50:45Z
date_updated: 2021-03-05T17:50:45Z
file_id: '9223'
file_name: DOI_SiteControlledHWs.zip
file_size: 13317557
relation: main_file
- access_level: open_access
checksum: a1dc5f710ba4b3bb7f248195ba754ab2
content_type: text/plain
creator: dernst
date_created: 2021-03-10T07:31:50Z
date_updated: 2021-03-10T07:31:50Z
file_id: '9233'
file_name: Readme.txt
file_size: 3515
relation: main_file
success: 1
file_date_updated: 2021-03-10T07:31:50Z
has_accepted_license: '1'
license: https://creativecommons.org/publicdomain/zero/1.0/
month: '03'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '7541'
relation: used_in_publication
status: public
status: public
title: 'Transport data for: Site‐controlled uniform Ge/Si Hut wires with electrically
tunable spin–orbit coupling'
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8375'
abstract:
- lang: eng
text: 'Supplementary movies showing the following sequences for spatio-temporarily
programmed shells: input geometry and actuation time landscape; comparison of
morphing processes from a camera recording and a simulation; final actuated shape.'
article_processing_charge: No
author:
- first_name: Ruslan
full_name: Guseinov, Ruslan
id: 3AB45EE2-F248-11E8-B48F-1D18A9856A87
last_name: Guseinov
orcid: 0000-0001-9819-5077
citation:
ama: 'Guseinov R. Supplementary data for “Computational design of curved thin shells:
from glass façades to programmable matter.” 2020. doi:10.15479/AT:ISTA:8375'
apa: 'Guseinov, R. (2020). Supplementary data for “Computational design of curved
thin shells: from glass façades to programmable matter.” Institute of Science
and Technology Austria. https://doi.org/10.15479/AT:ISTA:8375'
chicago: 'Guseinov, Ruslan. “Supplementary Data for ‘Computational Design of Curved
Thin Shells: From Glass Façades to Programmable Matter.’” Institute of Science
and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8375.'
ieee: 'R. Guseinov, “Supplementary data for ‘Computational design of curved thin
shells: from glass façades to programmable matter.’” Institute of Science and
Technology Austria, 2020.'
ista: 'Guseinov R. 2020. Supplementary data for ‘Computational design of curved
thin shells: from glass façades to programmable matter’, Institute of Science
and Technology Austria, 10.15479/AT:ISTA:8375.'
mla: 'Guseinov, Ruslan. Supplementary Data for “Computational Design of Curved
Thin Shells: From Glass Façades to Programmable Matter.” Institute of Science
and Technology Austria, 2020, doi:10.15479/AT:ISTA:8375.'
short: R. Guseinov, (2020).
contributor:
- contributor_type: researcher
first_name: Ruslan
id: 3AB45EE2-F248-11E8-B48F-1D18A9856A87
last_name: Guseinov
orcid: 0000-0001-9819-5077
- contributor_type: researcher
first_name: Connor
last_name: McMahan
- contributor_type: researcher
first_name: Jesus
id: 2DC83906-F248-11E8-B48F-1D18A9856A87
last_name: Perez Rodriguez
- contributor_type: researcher
first_name: Chiara
last_name: Daraio
- contributor_type: researcher
first_name: Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
date_created: 2020-09-11T09:52:54Z
date_published: 2020-09-21T00:00:00Z
date_updated: 2024-02-21T12:44:29Z
day: '21'
ddc:
- '000'
department:
- _id: BeBi
doi: 10.15479/AT:ISTA:8375
ec_funded: 1
file:
- access_level: open_access
checksum: 4029ffd65fb82ef2366b2fc2a4908e16
content_type: video/mp4
creator: rguseino
date_created: 2020-09-11T09:45:21Z
date_updated: 2020-09-11T09:45:21Z
file_id: '8376'
file_name: supplementary_movie_1.mp4
file_size: 29214988
relation: main_file
success: 1
- access_level: open_access
checksum: 8ed03b04d80f1a4e622cb22e6100afd8
content_type: video/mp4
creator: rguseino
date_created: 2020-09-11T09:45:25Z
date_updated: 2020-09-11T09:45:25Z
file_id: '8377'
file_name: supplementary_movie_2.mp4
file_size: 28449475
relation: main_file
success: 1
- access_level: open_access
checksum: ad6864afb5e694e5c52a88fba4e02eea
content_type: video/mp4
creator: rguseino
date_created: 2020-09-11T09:45:28Z
date_updated: 2020-09-11T09:45:28Z
file_id: '8378'
file_name: supplementary_movie_3.mp4
file_size: 26315853
relation: main_file
success: 1
- access_level: open_access
checksum: b079cef7871fe1afb69af0e2b099f3b1
content_type: video/mp4
creator: rguseino
date_created: 2020-09-11T09:45:33Z
date_updated: 2020-09-11T09:45:33Z
file_id: '8379'
file_name: supplementary_movie_4.mp4
file_size: 25198755
relation: main_file
success: 1
- access_level: open_access
checksum: 9d1d48a8ed5c109a999c51b044ee523d
content_type: video/mp4
creator: rguseino
date_created: 2020-09-11T09:45:36Z
date_updated: 2020-09-11T09:45:36Z
file_id: '8380'
file_name: supplementary_movie_5.mp4
file_size: 29011354
relation: main_file
success: 1
- access_level: open_access
checksum: d414d0059e982d752d218756b3c3ce05
content_type: text/plain
creator: rguseino
date_created: 2020-09-11T09:52:36Z
date_updated: 2020-09-11T09:52:36Z
file_id: '8381'
file_name: readme.txt
file_size: 586
relation: main_file
success: 1
file_date_updated: 2020-09-11T09:52:36Z
has_accepted_license: '1'
month: '09'
oa: 1
oa_version: Published Version
project:
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8366'
relation: used_in_publication
status: public
status: public
title: 'Supplementary data for "Computational design of curved thin shells: from glass
façades to programmable matter"'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '7689'
abstract:
- lang: eng
text: "These are the supplementary research data to the publication \"Zero field
splitting of heavy-hole states in quantum dots\". All matrix files have the same
format. Within each column the bias voltage is changed. Each column corresponds
to either a different gate voltage or magnetic field. The voltage values are given
in mV, the current values in pA. Find a specific description in the included Readme
file.\r\n"
article_processing_charge: No
author:
- first_name: Georgios
full_name: Katsaros, Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
orcid: 0000-0001-8342-202X
citation:
ama: Katsaros G. Supplementary data for “Zero field splitting of heavy-hole states
in quantum dots.” 2020. doi:10.15479/AT:ISTA:7689
apa: Katsaros, G. (2020). Supplementary data for “Zero field splitting of heavy-hole
states in quantum dots.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:7689
chicago: Katsaros, Georgios. “Supplementary Data for ‘Zero Field Splitting of Heavy-Hole
States in Quantum Dots.’” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:7689.
ieee: G. Katsaros, “Supplementary data for ‘Zero field splitting of heavy-hole states
in quantum dots.’” Institute of Science and Technology Austria, 2020.
ista: Katsaros G. 2020. Supplementary data for ‘Zero field splitting of heavy-hole
states in quantum dots’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:7689.
mla: Katsaros, Georgios. Supplementary Data for “Zero Field Splitting of Heavy-Hole
States in Quantum Dots.” Institute of Science and Technology Austria, 2020,
doi:10.15479/AT:ISTA:7689.
short: G. Katsaros, (2020).
contributor:
- contributor_type: contact_person
first_name: Georgios
id: 38DB5788-F248-11E8-B48F-1D18A9856A87
last_name: Katsaros
date_created: 2020-05-01T15:14:46Z
date_published: 2020-05-01T00:00:00Z
date_updated: 2024-02-21T12:44:02Z
day: '01'
ddc:
- '530'
department:
- _id: GeKa
doi: 10.15479/AT:ISTA:7689
ec_funded: 1
file:
- access_level: open_access
checksum: d23c0cb9e2d19e14e2f902b88b97c05d
content_type: application/x-zip-compressed
creator: gkatsaro
date_created: 2020-05-01T15:13:28Z
date_updated: 2020-07-14T12:48:02Z
file_id: '7786'
file_name: DOI_ZeroFieldSplitting.zip
file_size: 5514403
relation: main_file
file_date_updated: 2020-07-14T12:48:02Z
has_accepted_license: '1'
month: '05'
oa: 1
oa_version: Published Version
project:
- _id: 237E5020-32DE-11EA-91FC-C7463DDC885E
call_identifier: H2020
grant_number: '862046'
name: TOPOLOGICALLY PROTECTED AND SCALABLE QUANTUM BITS
- _id: 237B3DA4-32DE-11EA-91FC-C7463DDC885E
call_identifier: FWF
grant_number: P32235
name: Towards scalable hut wire quantum devices
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8203'
relation: used_in_publication
status: public
status: public
title: Supplementary data for "Zero field splitting of heavy-hole states in quantum
dots"
tmp:
image: /images/cc_0.png
legal_code_url: https://creativecommons.org/publicdomain/zero/1.0/legalcode
name: Creative Commons Public Domain Dedication (CC0 1.0)
short: CC0 (1.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8761'
acknowledged_ssus:
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article_processing_charge: No
author:
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full_name: Guseinov, Ruslan
id: 3AB45EE2-F248-11E8-B48F-1D18A9856A87
last_name: Guseinov
orcid: 0000-0001-9819-5077
citation:
ama: Guseinov R. Supplementary data for “Computational design of cold bent glass
façades.” 2020. doi:10.15479/AT:ISTA:8761
apa: Guseinov, R. (2020). Supplementary data for “Computational design of cold bent
glass façades.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:8761
chicago: Guseinov, Ruslan. “Supplementary Data for ‘Computational Design of Cold
Bent Glass Façades.’” Institute of Science and Technology Austria, 2020. https://doi.org/10.15479/AT:ISTA:8761.
ieee: R. Guseinov, “Supplementary data for ‘Computational design of cold bent glass
façades.’” Institute of Science and Technology Austria, 2020.
ista: Guseinov R. 2020. Supplementary data for ‘Computational design of cold bent
glass façades’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:8761.
mla: Guseinov, Ruslan. Supplementary Data for “Computational Design of Cold Bent
Glass Façades.” Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8761.
short: R. Guseinov, (2020).
contributor:
- contributor_type: researcher
first_name: Konstantinos
last_name: Gavriil
- contributor_type: researcher
first_name: Ruslan
id: 3AB45EE2-F248-11E8-B48F-1D18A9856A87
last_name: Guseinov
orcid: 0000-0001-9819-5077
- contributor_type: researcher
first_name: Jesus
id: 2DC83906-F248-11E8-B48F-1D18A9856A87
last_name: Perez Rodriguez
- contributor_type: researcher
first_name: Davide
last_name: Pellis
- contributor_type: researcher
first_name: Paul M
id: 13C09E74-18D9-11E9-8878-32CFE5697425
last_name: Henderson
orcid: 0000-0002-5198-7445
- contributor_type: researcher
first_name: Florian
last_name: Rist
- contributor_type: researcher
first_name: Helmut
last_name: Pottmann
- contributor_type: researcher
first_name: Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
date_created: 2020-11-16T10:47:18Z
date_published: 2020-11-23T00:00:00Z
date_updated: 2024-02-21T12:43:22Z
day: '23'
ddc:
- '000'
department:
- _id: BeBi
doi: 10.15479/AT:ISTA:8761
ec_funded: 1
file:
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checksum: f5ae57b97017b9f61081032703361233
content_type: application/x-gzip
creator: rguseino
date_created: 2020-11-16T10:31:29Z
date_updated: 2020-11-16T10:31:29Z
file_id: '8762'
file_name: mdn_model.tar.gz
file_size: 15378270
relation: main_file
success: 1
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checksum: b0d25e04060ee78c585ee2f23542c744
content_type: application/x-gzip
creator: rguseino
date_created: 2020-11-16T10:43:23Z
date_updated: 2020-11-16T10:43:23Z
file_id: '8763'
file_name: optimal_panels_data.tar.gz
file_size: 615387734
relation: main_file
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content_type: text/plain
creator: rguseino
date_created: 2020-11-18T10:04:59Z
date_updated: 2020-11-18T10:04:59Z
file_id: '8770'
file_name: readme.txt
file_size: 1228
relation: main_file
success: 1
file_date_updated: 2020-11-18T10:04:59Z
has_accepted_license: '1'
month: '11'
oa: 1
oa_version: Published Version
project:
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publisher: Institute of Science and Technology Austria
related_material:
link:
- relation: software
url: https://github.com/russelmann/cold-glass-acm
record:
- id: '8562'
relation: used_in_publication
status: public
status: public
title: Supplementary data for "Computational design of cold bent glass façades"
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '8563'
abstract:
- lang: eng
text: "Supplementary data provided for the provided for the publication:\r\nIgor
Gridchyn , Philipp Schoenenberger , Joseph O'Neill , Jozsef Csicsvari (2020) Optogenetic
inhibition-mediated activity-dependent modification of CA1 pyramidal-interneuron
connections during behavior. Elife."
article_processing_charge: No
author:
- first_name: Jozsef L
full_name: Csicsvari, Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
- first_name: Igor
full_name: Gridchyn, Igor
id: 4B60654C-F248-11E8-B48F-1D18A9856A87
last_name: Gridchyn
orcid: 0000-0002-1807-1929
- first_name: Philipp
full_name: Schönenberger, Philipp
id: 3B9D816C-F248-11E8-B48F-1D18A9856A87
last_name: Schönenberger
citation:
ama: Csicsvari JL, Gridchyn I, Schönenberger P. Optogenetic alteration of hippocampal
network activity. 2020. doi:10.15479/AT:ISTA:8563
apa: Csicsvari, J. L., Gridchyn, I., & Schönenberger, P. (2020). Optogenetic
alteration of hippocampal network activity. Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:8563
chicago: Csicsvari, Jozsef L, Igor Gridchyn, and Philipp Schönenberger. “Optogenetic
Alteration of Hippocampal Network Activity.” Institute of Science and Technology
Austria, 2020. https://doi.org/10.15479/AT:ISTA:8563.
ieee: J. L. Csicsvari, I. Gridchyn, and P. Schönenberger, “Optogenetic alteration
of hippocampal network activity.” Institute of Science and Technology Austria,
2020.
ista: Csicsvari JL, Gridchyn I, Schönenberger P. 2020. Optogenetic alteration of
hippocampal network activity, Institute of Science and Technology Austria, 10.15479/AT:ISTA:8563.
mla: Csicsvari, Jozsef L., et al. Optogenetic Alteration of Hippocampal Network
Activity. Institute of Science and Technology Austria, 2020, doi:10.15479/AT:ISTA:8563.
short: J.L. Csicsvari, I. Gridchyn, P. Schönenberger, (2020).
contributor:
- contributor_type: project_leader
first_name: Jozsef L
id: 3FA14672-F248-11E8-B48F-1D18A9856A87
last_name: Csicsvari
orcid: 0000-0002-5193-4036
date_created: 2020-09-23T14:39:54Z
date_published: 2020-10-19T00:00:00Z
date_updated: 2024-02-21T12:43:41Z
day: '19'
ddc:
- '570'
department:
- _id: JoCs
doi: 10.15479/AT:ISTA:8563
file:
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checksum: a16098a6d172f9c42ab5af5f6991668c
content_type: application/x-compressed
creator: jozsef
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date_updated: 2020-09-23T14:36:17Z
file_id: '8564'
file_name: upload.tgz
file_size: 145243906
relation: main_file
success: 1
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checksum: 0bfc54b7e14c0694cd081617318ba606
content_type: application/vnd.openxmlformats-officedocument.wordprocessingml.document
creator: jozsef
date_created: 2020-10-19T10:12:29Z
date_updated: 2020-10-19T10:12:29Z
file_id: '8675'
file_name: redme.docx
file_size: 11648
relation: main_file
success: 1
file_date_updated: 2020-10-19T10:12:29Z
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by-nc-nd/4.0/
month: '10'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8740'
relation: used_in_publication
status: public
status: public
title: Optogenetic alteration of hippocampal network activity
tmp:
image: /images/cc_by_nc_nd.png
legal_code_url: https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International
(CC BY-NC-ND 4.0)
short: CC BY-NC-ND (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '14592'
abstract:
- lang: eng
text: Cryo-electron microscopy (cryo-EM) of cellular specimens provides insights
into biological processes and structures within a native context. However, a major
challenge still lies in the efficient and reproducible preparation of adherent
cells for subsequent cryo-EM analysis. This is due to the sensitivity of many
cellular specimens to the varying seeding and culturing conditions required for
EM experiments, the often limited amount of cellular material and also the fragility
of EM grids and their substrate. Here, we present low-cost and reusable 3D printed
grid holders, designed to improve specimen preparation when culturing challenging
cellular samples directly on grids. The described grid holders increase cell culture
reproducibility and throughput, and reduce the resources required for cell culturing.
We show that grid holders can be integrated into various cryo-EM workflows, including
micro-patterning approaches to control cell seeding on grids, and for generating
samples for cryo-focused ion beam milling and cryo-electron tomography experiments.
Their adaptable design allows for the generation of specialized grid holders customized
to a large variety of applications.
article_processing_charge: No
author:
- first_name: Florian KM
full_name: Schur, Florian KM
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
citation:
ama: Schur FK. STL-files for 3D-printed grid holders described in Fäßler F, Zens
B, et al.; 3D printed cell culture grid holders for improved cellular specimen
preparation in cryo-electron microscopy. 2020. doi:10.15479/AT:ISTA:14592
apa: Schur, F. K. (2020). STL-files for 3D-printed grid holders described in Fäßler
F, Zens B, et al.; 3D printed cell culture grid holders for improved cellular
specimen preparation in cryo-electron microscopy. Institute of Science and Technology
Austria. https://doi.org/10.15479/AT:ISTA:14592
chicago: Schur, Florian KM. “STL-Files for 3D-Printed Grid Holders Described in
Fäßler F, Zens B, et Al.; 3D Printed Cell Culture Grid Holders for Improved Cellular
Specimen Preparation in Cryo-Electron Microscopy.” Institute of Science and Technology
Austria, 2020. https://doi.org/10.15479/AT:ISTA:14592.
ieee: F. K. Schur, “STL-files for 3D-printed grid holders described in Fäßler F,
Zens B, et al.; 3D printed cell culture grid holders for improved cellular specimen
preparation in cryo-electron microscopy.” Institute of Science and Technology
Austria, 2020.
ista: Schur FK. 2020. STL-files for 3D-printed grid holders described in Fäßler
F, Zens B, et al.; 3D printed cell culture grid holders for improved cellular
specimen preparation in cryo-electron microscopy, Institute of Science and Technology
Austria, 10.15479/AT:ISTA:14592.
mla: Schur, Florian KM. STL-Files for 3D-Printed Grid Holders Described in Fäßler
F, Zens B, et Al.; 3D Printed Cell Culture Grid Holders for Improved Cellular
Specimen Preparation in Cryo-Electron Microscopy. Institute of Science and
Technology Austria, 2020, doi:10.15479/AT:ISTA:14592.
short: F.K. Schur, (2020).
contributor:
- contributor_type: researcher
first_name: Florian
id: 404F5528-F248-11E8-B48F-1D18A9856A87
last_name: Fäßler
orcid: 0000-0001-7149-769X
- contributor_type: researcher
first_name: Bettina
id: 45FD126C-F248-11E8-B48F-1D18A9856A87
last_name: Zens
- contributor_type: researcher
first_name: Robert
id: 4E01D6B4-F248-11E8-B48F-1D18A9856A87
last_name: Hauschild
- contributor_type: researcher
first_name: Florian KM
id: 48AD8942-F248-11E8-B48F-1D18A9856A87
last_name: Schur
orcid: 0000-0003-4790-8078
date_created: 2023-11-22T15:00:57Z
date_published: 2020-12-01T00:00:00Z
date_updated: 2024-02-21T12:44:48Z
day: '01'
ddc:
- '570'
department:
- _id: FlSc
doi: 10.15479/AT:ISTA:14592
file:
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checksum: 0108616e2a59e51879ea51299a29b091
content_type: application/zip
creator: fschur
date_created: 2023-11-22T14:58:44Z
date_updated: 2023-11-22T14:58:44Z
file_id: '14593'
file_name: 3Dprint-files_download_v2.zip
file_size: 49297
relation: main_file
success: 1
- access_level: open_access
checksum: 4c66ddedee4d01c1c4a7978208350cfc
content_type: text/plain
creator: cchlebak
date_created: 2023-12-01T10:39:59Z
date_updated: 2023-12-01T10:39:59Z
file_id: '14637'
file_name: readme.txt
file_size: 641
relation: main_file
success: 1
file_date_updated: 2023-12-01T10:39:59Z
has_accepted_license: '1'
license: https://creativecommons.org/licenses/by-nc-sa/4.0/
month: '12'
oa: 1
oa_version: Published Version
project:
- _id: 9B954C5C-BA93-11EA-9121-9846C619BF3A
grant_number: P33367
name: Structure and isoform diversity of the Arp2/3 complex
publisher: Institute of Science and Technology Austria
related_material:
record:
- id: '8586'
relation: research_data
status: public
status: public
title: STL-files for 3D-printed grid holders described in Fäßler F, Zens B, et al.;
3D printed cell culture grid holders for improved cellular specimen preparation
in cryo-electron microscopy
tmp:
image: /images/cc_by_nc_sa.png
legal_code_url: https://creativecommons.org/licenses/by-nc-sa/4.0/legalcode
name: Creative Commons Attribution-NonCommercial-ShareAlike 4.0 International (CC
BY-NC-SA 4.0)
short: CC BY-NC-SA (4.0)
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2020'
...
---
_id: '7016'
abstract:
- lang: eng
text: Organisms cope with change by employing transcriptional regulators. However,
when faced with rare environments, the evolution of transcriptional regulators
and their promoters may be too slow. We ask whether the intrinsic instability
of gene duplication and amplification provides a generic alternative to canonical
gene regulation. By real-time monitoring of gene copy number mutations in E. coli,
we show that gene duplications and amplifications enable adaptation to fluctuating
environments by rapidly generating copy number, and hence expression level, polymorphism.
This ‘amplification-mediated gene expression tuning’ occurs on timescales similar
to canonical gene regulation and can deal with rapid environmental changes. Mathematical
modeling shows that amplifications also tune gene expression in stochastic environments
where transcription factor-based schemes are hard to evolve or maintain. The fleeting
nature of gene amplifications gives rise to a generic population-level mechanism
that relies on genetic heterogeneity to rapidly tune expression of any gene, without
leaving any genomic signature.
article_processing_charge: No
author:
- first_name: Isabella
full_name: Tomanek, Isabella
id: 3981F020-F248-11E8-B48F-1D18A9856A87
last_name: Tomanek
orcid: 0000-0001-6197-363X
citation:
ama: Tomanek I. Data for the paper “Gene amplification as a form of population-level
gene expression regulation.” 2019. doi:10.15479/AT:ISTA:7016
apa: Tomanek, I. (2019). Data for the paper “Gene amplification as a form of population-level
gene expression regulation.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:7016
chicago: Tomanek, Isabella. “Data for the Paper ‘Gene Amplification as a Form of
Population-Level Gene Expression Regulation.’” Institute of Science and Technology
Austria, 2019. https://doi.org/10.15479/AT:ISTA:7016.
ieee: I. Tomanek, “Data for the paper ‘Gene amplification as a form of population-level
gene expression regulation.’” Institute of Science and Technology Austria, 2019.
ista: Tomanek I. 2019. Data for the paper ‘Gene amplification as a form of population-level
gene expression regulation’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:7016.
mla: Tomanek, Isabella. Data for the Paper “Gene Amplification as a Form of Population-Level
Gene Expression Regulation.” Institute of Science and Technology Austria,
2019, doi:10.15479/AT:ISTA:7016.
short: I. Tomanek, (2019).
contributor:
- contributor_type: project_leader
first_name: Calin C
id: 47F8433E-F248-11E8-B48F-1D18A9856A87
last_name: Guet
orcid: 0000-0001-6220-2052
date_created: 2019-11-13T09:07:31Z
date_published: 2019-11-13T00:00:00Z
date_updated: 2024-02-21T12:45:25Z
day: '13'
ddc:
- '576'
department:
- _id: CaGu
doi: 10.15479/AT:ISTA:7016
file:
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checksum: 72441055043eda4cbf1398a422e2c118
content_type: application/octet-stream
creator: itomanek
date_created: 2019-11-13T08:52:21Z
date_updated: 2020-07-14T12:47:47Z
description: Illumina whole genome sequence data for Locus 1 - amplified.
file_id: '7017'
file_name: D8_S35_R2_001.fastq
file_size: 2456192500
relation: main_file
title: Locus1_amplified
- access_level: open_access
checksum: a4ac50bf655d9c751f0305ade5c2ee16
content_type: application/octet-stream
creator: itomanek
date_created: 2019-11-13T08:52:59Z
date_updated: 2020-07-14T12:47:47Z
description: Illumina whole genome sequence data for Locus 1 - ancestral.
file_id: '7018'
file_name: IT028_S11_R2_001.fastq
file_size: 2833452234
relation: main_file
title: Locus1_ancestral
- access_level: open_access
checksum: 5b227708ff478ca06e3f0448a4efdc2f
content_type: application/octet-stream
creator: itomanek
date_created: 2019-11-13T08:54:10Z
date_updated: 2020-07-14T12:47:47Z
description: Illumina whole genome sequence data for Locus 1 - amplified, after
DOG-selection.
file_id: '7019'
file_name: D8-DOG1_S47_R2_001.fastq
file_size: 2878017264
relation: main_file
title: Locus1_amplified_DOG
- access_level: open_access
checksum: d9550a4c044116075fa83f8f2ea31d6f
content_type: application/octet-stream
creator: itomanek
date_created: 2019-11-13T08:54:27Z
date_updated: 2020-07-14T12:47:47Z
description: Illumina whole genome sequence data for Locus 2 - amplified.
file_id: '7020'
file_name: D4_S71_R2_001.fastq
file_size: 2180826995
relation: main_file
title: Locus2_amplified
- access_level: open_access
checksum: 466ceb302c020ac013007a879fcde69d
content_type: application/octet-stream
creator: itomanek
date_created: 2019-11-13T08:55:58Z
date_updated: 2020-07-14T12:47:47Z
description: Illumina whole genome sequence data for Locus 2 - ancestral.
file_id: '7021'
file_name: IT030_S23_R2_001.fastq
file_size: 2108826444
relation: main_file
title: Locus2_ancestral
- access_level: open_access
checksum: 8aeb1da771713c7baa5a847eff889604
content_type: application/octet-stream
creator: itomanek
date_created: 2019-11-21T12:31:01Z
date_updated: 2020-07-14T12:47:47Z
description: Illumina whole genome sequence data for Locus 2 - amplified, after
DOG-selection.
file_id: '7092'
file_name: D4-DOG1_S83_R2_001.fastq
file_size: 3144330494
relation: main_file
title: Locus2_amplified_DOG
- access_level: open_access
checksum: bf7d4b053f14af4655fb5574209fdb2d
content_type: application/zip
creator: itomanek
date_created: 2020-01-14T11:22:27Z
date_updated: 2020-07-14T12:47:47Z
description: Compressed genbank file format containing the sequence of the chromosomal
reporter gene cassette.
file_id: '7273'
file_name: galK_dual_reporter_cassette.gb.zip
file_size: 4179
relation: main_file
title: DNA sequence of the chromosomal reporter gene cassette
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checksum: 5e91cee2eff6f4a7cde456c6fb07c2ff
content_type: text/plain
creator: dernst
date_created: 2020-01-15T14:15:55Z
date_updated: 2020-07-14T12:47:47Z
file_id: '7335'
file_name: Readme_7016.txt
file_size: 435
relation: main_file
title: Read_me_sequence_data
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content_type: application/zip
creator: itomanek
date_created: 2020-01-22T15:44:16Z
date_updated: 2020-07-14T12:47:47Z
description: FACS data associated with Fig. 2c - see read_me_FACS
file_id: '7351'
file_name: FACS_data.xlsx.zip
file_size: 3765861
relation: main_file
title: FACS data
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checksum: a85caf092ae4b17668f70af2d93fad00
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creator: itomanek
date_created: 2020-01-22T15:44:16Z
date_updated: 2020-07-14T12:47:47Z
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date_created: 2020-01-22T15:44:16Z
date_updated: 2020-07-14T12:47:47Z
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description: microfluidics time trace data - see read_me_microfluidics
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title: microfluidics data
file_date_updated: 2020-07-14T12:47:47Z
has_accepted_license: '1'
keyword:
- Escherichia coli
- gene amplification
- galactose
- DOG
- experimental evolution
- Illumina sequence data
- FACS data
- microfluidics data
month: '11'
oa: 1
oa_version: Published Version
publisher: Institute of Science and Technology Austria
related_material:
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status: public
status: public
title: Data for the paper "Gene amplification as a form of population-level gene expression
regulation"
type: research_data
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2019'
...