---
_id: '6983'
abstract:
- lang: eng
text: Malaria, a disease caused by parasites of the Plasmodium genus, begins when
Plasmodium-infected mosquitoes inject malaria sporozoites while searching for
blood. Sporozoites migrate from the skin via blood to the liver, infect hepatocytes,
and form liver stages which in mice 48 h later escape into blood and cause clinical
malaria. Vaccine-induced activated or memory CD8 T cells are capable of locating
and eliminating all liver stages in 48 h, thus preventing the blood-stage disease.
However, the rules of how CD8 T cells are able to locate all liver stages within
a relatively short time period remains poorly understood. We recently reported
formation of clusters consisting of variable numbers of activated CD8 T cells
around Plasmodium yoelii (Py)-infected hepatocytes. Using a combination of experimental
data and mathematical models we now provide additional insights into mechanisms
of formation of these clusters. First, we show that a model in which cluster formation
is driven exclusively by T-cell-extrinsic factors, such as variability in “attractiveness”
of different liver stages, cannot explain distribution of cluster sizes in different
experimental conditions. In contrast, the model in which cluster formation is
driven by the positive feedback loop (i.e., larger clusters attract more CD8 T
cells) can accurately explain the available data. Second, while both Py-specific
CD8 T cells and T cells of irrelevant specificity (non-specific CD8 T cells) are
attracted to the clusters, we found no evidence that non-specific CD8 T cells
play a role in cluster formation. Third and finally, mathematical modeling suggested
that formation of clusters occurs rapidly, within few hours after adoptive transfer
of CD8 T cells, thus illustrating high efficiency of CD8 T cells in locating their
targets in complex peripheral organs, such as the liver. Taken together, our analysis
provides novel insights into and attempts to discriminate between alternative
mechanisms driving the formation of clusters of antigen-specific CD8 T cells in
the liver.
article_number: '2153'
article_processing_charge: No
article_type: original
author:
- first_name: Réka K
full_name: Kelemen, Réka K
id: 48D3F8DE-F248-11E8-B48F-1D18A9856A87
last_name: Kelemen
orcid: 0000-0002-8489-9281
- first_name: H
full_name: Rajakaruna, H
last_name: Rajakaruna
- first_name: IA
full_name: Cockburn, IA
last_name: Cockburn
- first_name: VV
full_name: Ganusov, VV
last_name: Ganusov
citation:
ama: Kelemen RK, Rajakaruna H, Cockburn I, Ganusov V. Clustering of activated CD8
T cells around Malaria-infected hepatocytes is rapid and is driven by antigen-specific
cells. Frontiers in Immunology. 2019;10. doi:10.3389/fimmu.2019.02153
apa: Kelemen, R. K., Rajakaruna, H., Cockburn, I., & Ganusov, V. (2019). Clustering
of activated CD8 T cells around Malaria-infected hepatocytes is rapid and is driven
by antigen-specific cells. Frontiers in Immunology. Frontiers. https://doi.org/10.3389/fimmu.2019.02153
chicago: Kelemen, Réka K, H Rajakaruna, IA Cockburn, and VV Ganusov. “Clustering
of Activated CD8 T Cells around Malaria-Infected Hepatocytes Is Rapid and Is Driven
by Antigen-Specific Cells.” Frontiers in Immunology. Frontiers, 2019. https://doi.org/10.3389/fimmu.2019.02153.
ieee: R. K. Kelemen, H. Rajakaruna, I. Cockburn, and V. Ganusov, “Clustering of
activated CD8 T cells around Malaria-infected hepatocytes is rapid and is driven
by antigen-specific cells,” Frontiers in Immunology, vol. 10. Frontiers,
2019.
ista: Kelemen RK, Rajakaruna H, Cockburn I, Ganusov V. 2019. Clustering of activated
CD8 T cells around Malaria-infected hepatocytes is rapid and is driven by antigen-specific
cells. Frontiers in Immunology. 10, 2153.
mla: Kelemen, Réka K., et al. “Clustering of Activated CD8 T Cells around Malaria-Infected
Hepatocytes Is Rapid and Is Driven by Antigen-Specific Cells.” Frontiers in
Immunology, vol. 10, 2153, Frontiers, 2019, doi:10.3389/fimmu.2019.02153.
short: R.K. Kelemen, H. Rajakaruna, I. Cockburn, V. Ganusov, Frontiers in Immunology
10 (2019).
date_created: 2019-11-04T15:50:06Z
date_published: 2019-09-20T00:00:00Z
date_updated: 2023-08-30T07:18:23Z
day: '20'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.3389/fimmu.2019.02153
external_id:
isi:
- '000487187000001'
pmid:
- '31616407'
file:
- access_level: open_access
checksum: 68d1708f7aa412544159b498ef17a6b9
content_type: application/pdf
creator: dernst
date_created: 2019-11-04T15:54:00Z
date_updated: 2020-07-14T12:47:46Z
file_id: '6984'
file_name: 2019_FrontiersImmonology_Kelemen.pdf
file_size: 2083061
relation: main_file
file_date_updated: 2020-07-14T12:47:46Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
pmid: 1
publication: Frontiers in Immunology
publication_identifier:
issn:
- 1664-3224
publication_status: published
publisher: Frontiers
quality_controlled: '1'
scopus_import: '1'
status: public
title: Clustering of activated CD8 T cells around Malaria-infected hepatocytes is
rapid and is driven by antigen-specific cells
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2019'
...
---
_id: '6972'
abstract:
- lang: eng
text: 'We give fault-tolerant algorithms for establishing synchrony in distributed
systems in which each of thennodes has its own clock. Our algorithms operate in
a very strong fault model: we require self-stabilisation, i.e.,the initial state
of the system may be arbitrary, and there can be up to fJournal of the ACM. 2019;66(5). doi:10.1145/3339471
apa: Lenzen, C., & Rybicki, J. (2019). Self-stabilising Byzantine clock synchronisation
is almost as easy as consensus. Journal of the ACM. ACM. https://doi.org/10.1145/3339471
chicago: Lenzen, Christoph, and Joel Rybicki. “Self-Stabilising Byzantine Clock
Synchronisation Is Almost as Easy as Consensus.” Journal of the ACM. ACM,
2019. https://doi.org/10.1145/3339471.
ieee: C. Lenzen and J. Rybicki, “Self-stabilising Byzantine clock synchronisation
is almost as easy as consensus,” Journal of the ACM, vol. 66, no. 5. ACM,
2019.
ista: Lenzen C, Rybicki J. 2019. Self-stabilising Byzantine clock synchronisation
is almost as easy as consensus. Journal of the ACM. 66(5), 32.
mla: Lenzen, Christoph, and Joel Rybicki. “Self-Stabilising Byzantine Clock Synchronisation
Is Almost as Easy as Consensus.” Journal of the ACM, vol. 66, no. 5, 32,
ACM, 2019, doi:10.1145/3339471.
short: C. Lenzen, J. Rybicki, Journal of the ACM 66 (2019).
date_created: 2019-10-24T17:12:48Z
date_published: 2019-09-01T00:00:00Z
date_updated: 2023-08-30T07:07:23Z
day: '01'
ddc:
- '000'
department:
- _id: DaAl
doi: 10.1145/3339471
ec_funded: 1
external_id:
arxiv:
- '1705.06173'
isi:
- '000496514100001'
file:
- access_level: open_access
checksum: 7e5d95c478e0e393f4927fcf7e48194e
content_type: application/pdf
creator: dernst
date_created: 2019-10-25T12:58:38Z
date_updated: 2020-07-14T12:47:46Z
file_id: '6975'
file_name: 2019_JACM_Lenzen.pdf
file_size: 2183085
relation: main_file
file_date_updated: 2020-07-14T12:47:46Z
has_accepted_license: '1'
intvolume: ' 66'
isi: 1
issue: '5'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
project:
- _id: 260C2330-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '754411'
name: ISTplus - Postdoctoral Fellowships
publication: Journal of the ACM
publication_identifier:
issn:
- 0004-5411
publication_status: published
publisher: ACM
quality_controlled: '1'
scopus_import: '1'
status: public
title: Self-stabilising Byzantine clock synchronisation is almost as easy as consensus
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 66
year: '2019'
...
---
_id: '6942'
abstract:
- lang: eng
text: "Graph games and Markov decision processes (MDPs) are standard models in reactive
synthesis and verification of probabilistic systems with nondeterminism. The class
of \U0001D714 -regular winning conditions; e.g., safety, reachability, liveness,
parity conditions; provides a robust and expressive specification formalism for
properties that arise in analysis of reactive systems. The resolutions of nondeterminism
in games and MDPs are represented as strategies, and we consider succinct representation
of such strategies. The decision-tree data structure from machine learning retains
the flavor of decisions of strategies and allows entropy-based minimization to
obtain succinct trees. However, in contrast to traditional machine-learning problems
where small errors are allowed, for winning strategies in graph games and MDPs
no error is allowed, and the decision tree must represent the entire strategy.
In this work we propose decision trees with linear classifiers for representation
of strategies in graph games and MDPs. We have implemented strategy representation
using this data structure and we present experimental results for problems on
graph games and MDPs, which show that this new data structure presents a much
more efficient strategy representation as compared to standard decision trees."
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Pranav
full_name: Ashok, Pranav
last_name: Ashok
- first_name: Tomáš
full_name: Brázdil, Tomáš
last_name: Brázdil
- first_name: Krishnendu
full_name: Chatterjee, Krishnendu
id: 2E5DCA20-F248-11E8-B48F-1D18A9856A87
last_name: Chatterjee
orcid: 0000-0002-4561-241X
- first_name: Jan
full_name: Křetínský, Jan
last_name: Křetínský
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
- first_name: Viktor
full_name: Toman, Viktor
id: 3AF3DA7C-F248-11E8-B48F-1D18A9856A87
last_name: Toman
orcid: 0000-0001-9036-063X
citation:
ama: 'Ashok P, Brázdil T, Chatterjee K, Křetínský J, Lampert C, Toman V. Strategy
representation by decision trees with linear classifiers. In: 16th International
Conference on Quantitative Evaluation of Systems. Vol 11785. Springer Nature;
2019:109-128. doi:10.1007/978-3-030-30281-8_7'
apa: 'Ashok, P., Brázdil, T., Chatterjee, K., Křetínský, J., Lampert, C., &
Toman, V. (2019). Strategy representation by decision trees with linear classifiers.
In 16th International Conference on Quantitative Evaluation of Systems
(Vol. 11785, pp. 109–128). Glasgow, United Kingdom: Springer Nature. https://doi.org/10.1007/978-3-030-30281-8_7'
chicago: Ashok, Pranav, Tomáš Brázdil, Krishnendu Chatterjee, Jan Křetínský, Christoph
Lampert, and Viktor Toman. “Strategy Representation by Decision Trees with Linear
Classifiers.” In 16th International Conference on Quantitative Evaluation of
Systems, 11785:109–28. Springer Nature, 2019. https://doi.org/10.1007/978-3-030-30281-8_7.
ieee: P. Ashok, T. Brázdil, K. Chatterjee, J. Křetínský, C. Lampert, and V. Toman,
“Strategy representation by decision trees with linear classifiers,” in 16th
International Conference on Quantitative Evaluation of Systems, Glasgow, United
Kingdom, 2019, vol. 11785, pp. 109–128.
ista: 'Ashok P, Brázdil T, Chatterjee K, Křetínský J, Lampert C, Toman V. 2019.
Strategy representation by decision trees with linear classifiers. 16th International
Conference on Quantitative Evaluation of Systems. QEST: Quantitative Evaluation
of Systems, LNCS, vol. 11785, 109–128.'
mla: Ashok, Pranav, et al. “Strategy Representation by Decision Trees with Linear
Classifiers.” 16th International Conference on Quantitative Evaluation of Systems,
vol. 11785, Springer Nature, 2019, pp. 109–28, doi:10.1007/978-3-030-30281-8_7.
short: P. Ashok, T. Brázdil, K. Chatterjee, J. Křetínský, C. Lampert, V. Toman,
in:, 16th International Conference on Quantitative Evaluation of Systems, Springer
Nature, 2019, pp. 109–128.
conference:
end_date: 2019-09-12
location: Glasgow, United Kingdom
name: 'QEST: Quantitative Evaluation of Systems'
start_date: 2019-09-10
date_created: 2019-10-14T06:57:49Z
date_published: 2019-09-04T00:00:00Z
date_updated: 2023-08-30T06:59:36Z
day: '04'
department:
- _id: KrCh
- _id: ChLa
doi: 10.1007/978-3-030-30281-8_7
external_id:
arxiv:
- '1906.08178'
isi:
- '000679281300007'
intvolume: ' 11785'
isi: 1
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1906.08178
month: '09'
oa: 1
oa_version: Preprint
page: 109-128
project:
- _id: 25863FF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11407
name: Game Theory
- _id: 25F2ACDE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11402-N23
name: Rigorous Systems Engineering
- _id: 25892FC0-B435-11E9-9278-68D0E5697425
grant_number: ICT15-003
name: Efficient Algorithms for Computer Aided Verification
publication: 16th International Conference on Quantitative Evaluation of Systems
publication_identifier:
eisbn:
- '9783030302818'
isbn:
- '9783030302801'
issn:
- 0302-9743
publication_status: published
publisher: Springer Nature
quality_controlled: '1'
scopus_import: '1'
status: public
title: Strategy representation by decision trees with linear classifiers
type: conference
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11785
year: '2019'
...
---
_id: '6955'
abstract:
- lang: eng
text: We study few-body bound states of charged particles subject to attractive
zero-range/short-range plus repulsive Coulomb interparticle forces. The characteristic
length scales of the system at zero energy are set by the Coulomb length scale
D and the Coulomb-modified effective range r eff. We study shallow bound states
of charged particles with D >> r eff and show that these systems obey universal
scaling laws different from neutral particles. An accurate description of these
states requires both the Coulomb-modified scattering length and the effective
range unless the Coulomb interaction is very weak (D -> ). Our findings are relevant
for bound states whose spatial extent is significantly larger than the range of
the attractive potential. These states enjoy universality – their character is
independent of the shape of the short-range potential.
article_number: '135016'
article_processing_charge: No
article_type: original
author:
- first_name: C.H.
full_name: Schmickler, C.H.
last_name: Schmickler
- first_name: H.-W.
full_name: Hammer, H.-W.
last_name: Hammer
- first_name: Artem
full_name: Volosniev, Artem
id: 37D278BC-F248-11E8-B48F-1D18A9856A87
last_name: Volosniev
orcid: 0000-0003-0393-5525
citation:
ama: Schmickler CH, Hammer H-W, Volosniev A. Universal physics of bound states of
a few charged particles. Physics Letters B. 2019;798. doi:10.1016/j.physletb.2019.135016
apa: Schmickler, C. H., Hammer, H.-W., & Volosniev, A. (2019). Universal physics
of bound states of a few charged particles. Physics Letters B. Elsevier.
https://doi.org/10.1016/j.physletb.2019.135016
chicago: Schmickler, C.H., H.-W. Hammer, and Artem Volosniev. “Universal Physics
of Bound States of a Few Charged Particles.” Physics Letters B. Elsevier,
2019. https://doi.org/10.1016/j.physletb.2019.135016.
ieee: C. H. Schmickler, H.-W. Hammer, and A. Volosniev, “Universal physics of bound
states of a few charged particles,” Physics Letters B, vol. 798. Elsevier,
2019.
ista: Schmickler CH, Hammer H-W, Volosniev A. 2019. Universal physics of bound states
of a few charged particles. Physics Letters B. 798, 135016.
mla: Schmickler, C. H., et al. “Universal Physics of Bound States of a Few Charged
Particles.” Physics Letters B, vol. 798, 135016, Elsevier, 2019, doi:10.1016/j.physletb.2019.135016.
short: C.H. Schmickler, H.-W. Hammer, A. Volosniev, Physics Letters B 798 (2019).
date_created: 2019-10-18T18:33:32Z
date_published: 2019-11-10T00:00:00Z
date_updated: 2023-08-30T07:06:42Z
day: '10'
ddc:
- '530'
department:
- _id: MiLe
doi: 10.1016/j.physletb.2019.135016
external_id:
arxiv:
- '1904.00913'
isi:
- '000494939000086'
file:
- access_level: open_access
checksum: d27f983b34ea7dafdf356afbf9472fbf
content_type: application/pdf
creator: dernst
date_created: 2019-10-25T12:47:04Z
date_updated: 2020-07-14T12:47:46Z
file_id: '6974'
file_name: 2019_PhysicsLettersB_Schmickler.pdf
file_size: 528362
relation: main_file
file_date_updated: 2020-07-14T12:47:46Z
has_accepted_license: '1'
intvolume: ' 798'
isi: 1
language:
- iso: eng
month: '11'
oa: 1
oa_version: Published Version
publication: Physics Letters B
publication_identifier:
issn:
- 0370-2693
publication_status: published
publisher: Elsevier
quality_controlled: '1'
scopus_import: '1'
status: public
title: Universal physics of bound states of a few charged particles
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 798
year: '2019'
...
---
_id: '7005'
abstract:
- lang: eng
text: Activity-dependent bulk endocytosis generates synaptic vesicles (SVs) during
intense neuronal activity via a two-step process. First, bulk endosomes are formed
direct from the plasma membrane from which SVs are then generated. SV generation
from bulk endosomes requires the efflux of previously accumulated calcium and
activation of the protein phosphatase calcineurin. However, it is still unknown
how calcineurin mediates SV generation. We addressed this question using a series
of acute interventions that decoupled the generation of SVs from bulk endosomes
in rat primary neuronal culture. This was achieved by either disruption of protein–protein
interactions via delivery of competitive peptides, or inhibition of enzyme activity
by known inhibitors. SV generation was monitored using either a morphological
horseradish peroxidase assay or an optical assay that monitors the replenishment
of the reserve SV pool. We found that SV generation was inhibited by, (i) peptides
that disrupt calcineurin interactions, (ii) an inhibitor of dynamin I GTPase activity
and (iii) peptides that disrupt the phosphorylation-dependent dynamin I–syndapin
I interaction. Peptides that disrupted syndapin I interactions with eps15 homology
domain-containing proteins had no effect. This revealed that (i) calcineurin must
be localized at bulk endosomes to mediate its effect, (ii) dynamin I GTPase activity
is essential for SV fission and (iii) the calcineurin-dependent interaction between
dynamin I and syndapin I is essential for SV generation. We therefore propose
that a calcineurin-dependent dephosphorylation cascade that requires both dynamin
I GTPase and syndapin I lipid-deforming activity is essential for SV generation
from bulk endosomes.
article_processing_charge: No
article_type: original
author:
- first_name: Giselle T
full_name: Cheung, Giselle T
id: 471195F6-F248-11E8-B48F-1D18A9856A87
last_name: Cheung
orcid: 0000-0001-8457-2572
- first_name: Michael A.
full_name: Cousin, Michael A.
last_name: Cousin
citation:
ama: Cheung GT, Cousin MA. Synaptic vesicle generation from activity‐dependent bulk
endosomes requires a dephosphorylation‐dependent dynamin–syndapin interaction.
Journal of Neurochemistry. 2019;151(5):570-583. doi:10.1111/jnc.14862
apa: Cheung, G. T., & Cousin, M. A. (2019). Synaptic vesicle generation from
activity‐dependent bulk endosomes requires a dephosphorylation‐dependent dynamin–syndapin
interaction. Journal of Neurochemistry. Wiley. https://doi.org/10.1111/jnc.14862
chicago: Cheung, Giselle T, and Michael A. Cousin. “Synaptic Vesicle Generation
from Activity‐dependent Bulk Endosomes Requires a Dephosphorylation‐dependent
Dynamin–Syndapin Interaction.” Journal of Neurochemistry. Wiley, 2019.
https://doi.org/10.1111/jnc.14862.
ieee: G. T. Cheung and M. A. Cousin, “Synaptic vesicle generation from activity‐dependent
bulk endosomes requires a dephosphorylation‐dependent dynamin–syndapin interaction,”
Journal of Neurochemistry, vol. 151, no. 5. Wiley, pp. 570–583, 2019.
ista: Cheung GT, Cousin MA. 2019. Synaptic vesicle generation from activity‐dependent
bulk endosomes requires a dephosphorylation‐dependent dynamin–syndapin interaction.
Journal of Neurochemistry. 151(5), 570–583.
mla: Cheung, Giselle T., and Michael A. Cousin. “Synaptic Vesicle Generation from
Activity‐dependent Bulk Endosomes Requires a Dephosphorylation‐dependent Dynamin–Syndapin
Interaction.” Journal of Neurochemistry, vol. 151, no. 5, Wiley, 2019,
pp. 570–83, doi:10.1111/jnc.14862.
short: G.T. Cheung, M.A. Cousin, Journal of Neurochemistry 151 (2019) 570–583.
date_created: 2019-11-12T14:37:08Z
date_published: 2019-12-01T00:00:00Z
date_updated: 2023-08-30T07:21:50Z
day: '01'
ddc:
- '570'
department:
- _id: SiHi
doi: 10.1111/jnc.14862
external_id:
isi:
- '000490703100001'
pmid:
- '31479508'
file:
- access_level: open_access
checksum: ec1fb2aebb874009bc309adaada6e1d7
content_type: application/pdf
creator: dernst
date_created: 2020-02-05T10:30:02Z
date_updated: 2020-07-14T12:47:47Z
file_id: '7452'
file_name: 2019_JournNeurochemistry_Cheung.pdf
file_size: 4334962
relation: main_file
file_date_updated: 2020-07-14T12:47:47Z
has_accepted_license: '1'
intvolume: ' 151'
isi: 1
issue: '5'
language:
- iso: eng
month: '12'
oa: 1
oa_version: Published Version
page: 570-583
pmid: 1
publication: Journal of Neurochemistry
publication_identifier:
eissn:
- 1471-4159
issn:
- 0022-3042
publication_status: published
publisher: Wiley
quality_controlled: '1'
scopus_import: '1'
status: public
title: Synaptic vesicle generation from activity‐dependent bulk endosomes requires
a dephosphorylation‐dependent dynamin–syndapin interaction
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 151
year: '2019'
...