[{"file":[{"file_name":"2019_NewPhytologist_Zhang_accepted.pdf","access_level":"open_access","file_size":1099061,"content_type":"application/pdf","creator":"dernst","relation":"main_file","file_id":"8661","date_updated":"2020-10-14T08:59:33Z","date_created":"2020-10-14T08:59:33Z","checksum":"6488243334538f5c39099a701cbf76b9","success":1}],"oa_version":"Submitted Version","ddc":["580"],"status":"public","title":"Auxin-mediated statolith production for root gravitropism","intvolume":" 224","_id":"6504","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","abstract":[{"text":"Root gravitropism is one of the most important processes allowing plant adaptation to the land environment. Auxin plays a central role in mediating root gravitropism, but how auxin contributes to gravitational perception and the subsequent response is still unclear.\r\n\r\nHere, we showed that the local auxin maximum/gradient within the root apex, which is generated by the PIN directional auxin transporters, regulates the expression of three key starch granule synthesis genes, SS4, PGM and ADG1, which in turn influence the accumulation of starch granules that serve as a statolith perceiving gravity.\r\n\r\nMoreover, using the cvxIAA‐ccvTIR1 system, we also showed that TIR1‐mediated auxin signaling is required for starch granule formation and gravitropic response within root tips. In addition, axr3 mutants showed reduced auxin‐mediated starch granule accumulation and disruption of gravitropism within the root apex.\r\n\r\nOur results indicate that auxin‐mediated statolith production relies on the TIR1/AFB‐AXR3‐mediated auxin signaling pathway. In summary, we propose a dual role for auxin in gravitropism: the regulation of both gravity perception and response.","lang":"eng"}],"issue":"2","type":"journal_article","date_published":"2019-10-01T00:00:00Z","article_type":"original","page":"761-774","publication":"New Phytologist","citation":{"chicago":"Zhang, Yuzhou, P He, X Ma, Z Yang, C Pang, J Yu, G Wang, Jiří Friml, and G Xiao. “Auxin-Mediated Statolith Production for Root Gravitropism.” New Phytologist. Wiley, 2019. https://doi.org/10.1111/nph.15932.","mla":"Zhang, Yuzhou, et al. “Auxin-Mediated Statolith Production for Root Gravitropism.” New Phytologist, vol. 224, no. 2, Wiley, 2019, pp. 761–74, doi:10.1111/nph.15932.","short":"Y. Zhang, P. He, X. Ma, Z. Yang, C. Pang, J. Yu, G. Wang, J. Friml, G. Xiao, New Phytologist 224 (2019) 761–774.","ista":"Zhang Y, He P, Ma X, Yang Z, Pang C, Yu J, Wang G, Friml J, Xiao G. 2019. Auxin-mediated statolith production for root gravitropism. New Phytologist. 224(2), 761–774.","apa":"Zhang, Y., He, P., Ma, X., Yang, Z., Pang, C., Yu, J., … Xiao, G. (2019). Auxin-mediated statolith production for root gravitropism. New Phytologist. Wiley. https://doi.org/10.1111/nph.15932","ieee":"Y. Zhang et al., “Auxin-mediated statolith production for root gravitropism,” New Phytologist, vol. 224, no. 2. Wiley, pp. 761–774, 2019.","ama":"Zhang Y, He P, Ma X, et al. Auxin-mediated statolith production for root gravitropism. New Phytologist. 2019;224(2):761-774. doi:10.1111/nph.15932"},"day":"01","article_processing_charge":"No","has_accepted_license":"1","scopus_import":"1","date_created":"2019-05-28T14:33:26Z","date_updated":"2023-08-28T08:40:13Z","volume":224,"author":[{"last_name":"Zhang","first_name":"Yuzhou","orcid":"0000-0003-2627-6956","id":"3B6137F2-F248-11E8-B48F-1D18A9856A87","full_name":"Zhang, Yuzhou"},{"full_name":"He, P","last_name":"He","first_name":"P"},{"full_name":"Ma, X","last_name":"Ma","first_name":"X"},{"full_name":"Yang, Z","first_name":"Z","last_name":"Yang"},{"first_name":"C","last_name":"Pang","full_name":"Pang, C"},{"first_name":"J","last_name":"Yu","full_name":"Yu, J"},{"full_name":"Wang, G","last_name":"Wang","first_name":"G"},{"first_name":"Jiří","last_name":"Friml","id":"4159519E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8302-7596","full_name":"Friml, Jiří"},{"last_name":"Xiao","first_name":"G","full_name":"Xiao, G"}],"publication_status":"published","publisher":"Wiley","department":[{"_id":"JiFr"}],"year":"2019","pmid":1,"file_date_updated":"2020-10-14T08:59:33Z","language":[{"iso":"eng"}],"doi":"10.1111/nph.15932","isi":1,"quality_controlled":"1","oa":1,"external_id":{"isi":["000487184200024"],"pmid":["31111487"]},"month":"10","publication_identifier":{"eissn":["1469-8137"],"issn":["0028-646x"]}},{"author":[{"full_name":"Noda-García, Lianet","last_name":"Noda-García","first_name":"Lianet"},{"last_name":"Davidi","first_name":"Dan","full_name":"Davidi, Dan"},{"full_name":"Korenblum, Elisa","first_name":"Elisa","last_name":"Korenblum"},{"last_name":"Elazar","first_name":"Assaf","full_name":"Elazar, Assaf"},{"full_name":"Putintseva, Ekaterina","first_name":"Ekaterina","last_name":"Putintseva","id":"2EF67C84-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Asaph","last_name":"Aharoni","full_name":"Aharoni, Asaph"},{"last_name":"Tawfik","first_name":"Dan S.","full_name":"Tawfik, Dan S."}],"date_created":"2019-05-29T13:03:30Z","date_updated":"2023-08-28T08:39:47Z","volume":4,"year":"2019","publication_status":"published","department":[{"_id":"FyKo"}],"publisher":"Springer Nature","month":"07","publication_identifier":{"issn":["2058-5276"]},"doi":"10.1038/s41564-019-0412-y","language":[{"iso":"eng"}],"oa":1,"external_id":{"isi":["000480348200017"]},"main_file_link":[{"open_access":"1","url":"https://www.biorxiv.org/content/10.1101/340828v2"}],"isi":1,"quality_controlled":"1","abstract":[{"text":"How does environmental complexity affect the evolution of single genes? Here, we measured the effects of a set of Bacillus subtilis glutamate dehydrogenase mutants across 19 different environments—from phenotypically homogeneous single-cell populations in liquid media to heterogeneous biofilms, plant roots and soil populations. The effects of individual gene mutations on organismal fitness were highly reproducible in liquid cultures. However, 84% of the tested alleles showed opposing fitness effects under different growth conditions (sign environmental pleiotropy). In colony biofilms and soil samples, different alleles dominated in parallel replica experiments. Accordingly, we found that in these heterogeneous cell populations the fate of mutations was dictated by a combination of selection and drift. The latter relates to programmed prophage excisions that occurred during biofilm development. Overall, for each condition, a wide range of glutamate dehydrogenase mutations persisted and sometimes fixated as a result of the combined action of selection, pleiotropy and chance. However, over longer periods and in multiple environments, nearly all of this diversity would be lost—across all the environments and conditions that we tested, the wild type was the fittest allele.","lang":"eng"}],"issue":"7","type":"journal_article","oa_version":"Preprint","_id":"6506","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","title":"Chance and pleiotropy dominate genetic diversity in complex bacterial environments","status":"public","intvolume":" 4","day":"01","article_processing_charge":"No","scopus_import":"1","date_published":"2019-07-01T00:00:00Z","publication":"Nature Microbiology","citation":{"ama":"Noda-García L, Davidi D, Korenblum E, et al. Chance and pleiotropy dominate genetic diversity in complex bacterial environments. Nature Microbiology. 2019;4(7):1221–1230. doi:10.1038/s41564-019-0412-y","ieee":"L. Noda-García et al., “Chance and pleiotropy dominate genetic diversity in complex bacterial environments,” Nature Microbiology, vol. 4, no. 7. Springer Nature, pp. 1221–1230, 2019.","apa":"Noda-García, L., Davidi, D., Korenblum, E., Elazar, A., Putintseva, E., Aharoni, A., & Tawfik, D. S. (2019). Chance and pleiotropy dominate genetic diversity in complex bacterial environments. Nature Microbiology. Springer Nature. https://doi.org/10.1038/s41564-019-0412-y","ista":"Noda-García L, Davidi D, Korenblum E, Elazar A, Putintseva E, Aharoni A, Tawfik DS. 2019. Chance and pleiotropy dominate genetic diversity in complex bacterial environments. Nature Microbiology. 4(7), 1221–1230.","short":"L. Noda-García, D. Davidi, E. Korenblum, A. Elazar, E. Putintseva, A. Aharoni, D.S. Tawfik, Nature Microbiology 4 (2019) 1221–1230.","mla":"Noda-García, Lianet, et al. “Chance and Pleiotropy Dominate Genetic Diversity in Complex Bacterial Environments.” Nature Microbiology, vol. 4, no. 7, Springer Nature, 2019, pp. 1221–1230, doi:10.1038/s41564-019-0412-y.","chicago":"Noda-García, Lianet, Dan Davidi, Elisa Korenblum, Assaf Elazar, Ekaterina Putintseva, Asaph Aharoni, and Dan S. Tawfik. “Chance and Pleiotropy Dominate Genetic Diversity in Complex Bacterial Environments.” Nature Microbiology. Springer Nature, 2019. https://doi.org/10.1038/s41564-019-0412-y."},"article_type":"original","page":"1221–1230"},{"article_number":"134310","license":"https://creativecommons.org/licenses/by/4.0/","ec_funded":1,"file_date_updated":"2020-07-14T12:47:33Z","publisher":"Elsevier","department":[{"_id":"SaSi"}],"publication_status":"published","pmid":1,"year":"2019","volume":707,"date_created":"2019-06-05T13:16:24Z","date_updated":"2023-08-28T09:30:57Z","author":[{"full_name":"Maes, Margaret E","orcid":"0000-0001-9642-1085","id":"3838F452-F248-11E8-B48F-1D18A9856A87","last_name":"Maes","first_name":"Margaret E"},{"orcid":"0000-0001-9434-8902","id":"3483CF6C-F248-11E8-B48F-1D18A9856A87","last_name":"Colombo","first_name":"Gloria","full_name":"Colombo, Gloria"},{"id":"4C5E7B96-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5297-733X","first_name":"Rouven","last_name":"Schulz","full_name":"Schulz, Rouven"},{"full_name":"Siegert, Sandra","id":"36ACD32E-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8635-0877","first_name":"Sandra","last_name":"Siegert"}],"publication_identifier":{"issn":["0304-3940"]},"month":"08","project":[{"name":"International IST Doctoral Program","call_identifier":"H2020","_id":"2564DBCA-B435-11E9-9278-68D0E5697425","grant_number":"665385"},{"call_identifier":"H2020","name":"Microglia action towards neuronal circuit formation and function in health and disease","_id":"25D4A630-B435-11E9-9278-68D0E5697425","grant_number":"715571"},{"_id":"267F75D8-B435-11E9-9278-68D0E5697425","name":"Modulating microglia through G protein-coupled receptor (GPCR) signaling"}],"quality_controlled":"1","isi":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"external_id":{"isi":["000486094600037"],"pmid":["31158432"]},"language":[{"iso":"eng"}],"doi":"10.1016/j.neulet.2019.134310","type":"journal_article","abstract":[{"lang":"eng","text":"Microglia have emerged as a critical component of neurodegenerative diseases. Genetic manipulation of microglia can elucidate their functional impact in disease. In neuroscience, recombinant viruses such as lentiviruses and adeno-associated viruses (AAVs) have been successfully used to target various cell types in the brain, although effective transduction of microglia is rare. In this review, we provide a short background of lentiviruses and AAVs, and strategies for designing recombinant viral vectors. Then, we will summarize recent literature on successful microglial transductions in vitro and in vivo, and discuss the current challenges. Finally, we provide guidelines for reporting the efficiency and specificity of viral targeting in microglia, which will enable the microglial research community to assess and improve methodologies for future studies."}],"intvolume":" 707","ddc":["570"],"status":"public","title":"Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges","_id":"6521","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","oa_version":"Published Version","file":[{"creator":"dernst","file_size":1779287,"content_type":"application/pdf","access_level":"open_access","file_name":"2019_Neuroscience_Maes.pdf","checksum":"553c9dbd39727fbed55ee991c51ca4d1","date_updated":"2020-07-14T12:47:33Z","date_created":"2019-06-08T11:44:20Z","file_id":"6551","relation":"main_file"}],"scopus_import":"1","article_processing_charge":"No","has_accepted_license":"1","day":"10","article_type":"original","citation":{"ama":"Maes ME, Colombo G, Schulz R, Siegert S. Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges. Neuroscience Letters. 2019;707. doi:10.1016/j.neulet.2019.134310","ieee":"M. E. Maes, G. Colombo, R. Schulz, and S. Siegert, “Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges,” Neuroscience Letters, vol. 707. Elsevier, 2019.","apa":"Maes, M. E., Colombo, G., Schulz, R., & Siegert, S. (2019). Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges. Neuroscience Letters. Elsevier. https://doi.org/10.1016/j.neulet.2019.134310","ista":"Maes ME, Colombo G, Schulz R, Siegert S. 2019. Targeting microglia with lentivirus and AAV: Recent advances and remaining challenges. Neuroscience Letters. 707, 134310.","short":"M.E. Maes, G. Colombo, R. Schulz, S. Siegert, Neuroscience Letters 707 (2019).","mla":"Maes, Margaret E., et al. “Targeting Microglia with Lentivirus and AAV: Recent Advances and Remaining Challenges.” Neuroscience Letters, vol. 707, 134310, Elsevier, 2019, doi:10.1016/j.neulet.2019.134310.","chicago":"Maes, Margaret E, Gloria Colombo, Rouven Schulz, and Sandra Siegert. “Targeting Microglia with Lentivirus and AAV: Recent Advances and Remaining Challenges.” Neuroscience Letters. Elsevier, 2019. https://doi.org/10.1016/j.neulet.2019.134310."},"publication":"Neuroscience Letters","date_published":"2019-08-10T00:00:00Z"},{"author":[{"first_name":"Jordi","last_name":"Guiu","full_name":"Guiu, Jordi"},{"full_name":"Hannezo, Edouard B","orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","last_name":"Hannezo","first_name":"Edouard B"},{"first_name":"Shiro","last_name":"Yui","full_name":"Yui, Shiro"},{"first_name":"Samuel","last_name":"Demharter","full_name":"Demharter, Samuel"},{"full_name":"Ulyanchenko, Svetlana","first_name":"Svetlana","last_name":"Ulyanchenko"},{"full_name":"Maimets, Martti","first_name":"Martti","last_name":"Maimets"},{"full_name":"Jørgensen, Anne","last_name":"Jørgensen","first_name":"Anne"},{"first_name":"Signe","last_name":"Perlman","full_name":"Perlman, Signe"},{"full_name":"Lundvall, Lene","last_name":"Lundvall","first_name":"Lene"},{"first_name":"Linn Salto","last_name":"Mamsen","full_name":"Mamsen, Linn Salto"},{"first_name":"Agnete","last_name":"Larsen","full_name":"Larsen, Agnete"},{"last_name":"Olesen","first_name":"Rasmus H.","full_name":"Olesen, Rasmus H."},{"full_name":"Andersen, Claus Yding","first_name":"Claus Yding","last_name":"Andersen"},{"full_name":"Thuesen, Lea Langhoff","last_name":"Thuesen","first_name":"Lea Langhoff"},{"last_name":"Hare","first_name":"Kristine Juul","full_name":"Hare, Kristine Juul"},{"full_name":"Pers, Tune H.","first_name":"Tune H.","last_name":"Pers"},{"full_name":"Khodosevich, Konstantin","first_name":"Konstantin","last_name":"Khodosevich"},{"first_name":"Benjamin D.","last_name":"Simons","full_name":"Simons, Benjamin D."},{"full_name":"Jensen, Kim B.","first_name":"Kim B.","last_name":"Jensen"}],"date_created":"2019-06-02T21:59:14Z","date_updated":"2023-08-28T09:30:23Z","volume":570,"year":"2019","pmid":1,"publication_status":"published","department":[{"_id":"EdHa"}],"publisher":"Springer Nature","month":"06","publication_identifier":{"issn":["00280836"],"eissn":["14764687"]},"doi":"10.1038/s41586-019-1212-5","language":[{"iso":"eng"}],"oa":1,"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC6986928"}],"external_id":{"isi":["000470149000048"],"pmid":["31092921"]},"quality_controlled":"1","isi":1,"abstract":[{"text":"Adult intestinal stem cells are located at the bottom of crypts of Lieberkühn, where they express markers such as LGR5 1,2 and fuel the constant replenishment of the intestinal epithelium1. Although fetal LGR5-expressing cells can give rise to adult intestinal stem cells3,4, it remains unclear whether this population in the patterned epithelium represents unique intestinal stem-cell precursors. Here we show, using unbiased quantitative lineage-tracing approaches, biophysical modelling and intestinal transplantation, that all cells of the mouse intestinal epithelium—irrespective of their location and pattern of LGR5 expression in the fetal gut tube—contribute actively to the adult intestinal stem cell pool. Using 3D imaging, we find that during fetal development the villus undergoes gross remodelling and fission. This brings epithelial cells from the non-proliferative villus into the proliferative intervillus region, which enables them to contribute to the adult stem-cell niche. Our results demonstrate that large-scale remodelling of the intestinal wall and cell-fate specification are closely linked. Moreover, these findings provide a direct link between the observed plasticity and cellular reprogramming of differentiating cells in adult tissues following damage5,6,7,8,9, revealing that stem-cell identity is an induced rather than a hardwired property.","lang":"eng"}],"type":"journal_article","oa_version":"Submitted Version","_id":"6513","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","status":"public","title":"Tracing the origin of adult intestinal stem cells","intvolume":" 570","day":"06","article_processing_charge":"No","scopus_import":"1","date_published":"2019-06-06T00:00:00Z","publication":"Nature","citation":{"ista":"Guiu J, Hannezo EB, Yui S, Demharter S, Ulyanchenko S, Maimets M, Jørgensen A, Perlman S, Lundvall L, Mamsen LS, Larsen A, Olesen RH, Andersen CY, Thuesen LL, Hare KJ, Pers TH, Khodosevich K, Simons BD, Jensen KB. 2019. Tracing the origin of adult intestinal stem cells. Nature. 570, 107–111.","ieee":"J. Guiu et al., “Tracing the origin of adult intestinal stem cells,” Nature, vol. 570. Springer Nature, pp. 107–111, 2019.","apa":"Guiu, J., Hannezo, E. B., Yui, S., Demharter, S., Ulyanchenko, S., Maimets, M., … Jensen, K. B. (2019). Tracing the origin of adult intestinal stem cells. Nature. Springer Nature. https://doi.org/10.1038/s41586-019-1212-5","ama":"Guiu J, Hannezo EB, Yui S, et al. Tracing the origin of adult intestinal stem cells. Nature. 2019;570:107-111. doi:10.1038/s41586-019-1212-5","chicago":"Guiu, Jordi, Edouard B Hannezo, Shiro Yui, Samuel Demharter, Svetlana Ulyanchenko, Martti Maimets, Anne Jørgensen, et al. “Tracing the Origin of Adult Intestinal Stem Cells.” Nature. Springer Nature, 2019. https://doi.org/10.1038/s41586-019-1212-5.","mla":"Guiu, Jordi, et al. “Tracing the Origin of Adult Intestinal Stem Cells.” Nature, vol. 570, Springer Nature, 2019, pp. 107–11, doi:10.1038/s41586-019-1212-5.","short":"J. Guiu, E.B. Hannezo, S. Yui, S. Demharter, S. Ulyanchenko, M. Maimets, A. Jørgensen, S. Perlman, L. Lundvall, L.S. Mamsen, A. Larsen, R.H. Olesen, C.Y. Andersen, L.L. Thuesen, K.J. Hare, T.H. Pers, K. Khodosevich, B.D. Simons, K.B. Jensen, Nature 570 (2019) 107–111."},"article_type":"original","page":"107-111"},{"scopus_import":"1","day":"09","article_processing_charge":"No","article_type":"original","page":"3046-3055","publication":"Journal of Molecular Biology","citation":{"apa":"Tichy, A.-M., Gerrard, E. J., Legrand, J. M. D., Hobbs, R. M., & Janovjak, H. L. (2019). Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions. Journal of Molecular Biology. Elsevier. https://doi.org/10.1016/j.jmb.2019.05.033","ieee":"A.-M. Tichy, E. J. Gerrard, J. M. D. Legrand, R. M. Hobbs, and H. L. Janovjak, “Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions,” Journal of Molecular Biology, vol. 431, no. 17. Elsevier, pp. 3046–3055, 2019.","ista":"Tichy A-M, Gerrard EJ, Legrand JMD, Hobbs RM, Janovjak HL. 2019. Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions. Journal of Molecular Biology. 431(17), 3046–3055.","ama":"Tichy A-M, Gerrard EJ, Legrand JMD, Hobbs RM, Janovjak HL. Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions. Journal of Molecular Biology. 2019;431(17):3046-3055. doi:10.1016/j.jmb.2019.05.033","chicago":"Tichy, Alexandra-Madelaine, Elliot J. Gerrard, Julien M.D. Legrand, Robin M. Hobbs, and Harald L Janovjak. “Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein–Protein Interactions.” Journal of Molecular Biology. Elsevier, 2019. https://doi.org/10.1016/j.jmb.2019.05.033.","short":"A.-M. Tichy, E.J. Gerrard, J.M.D. Legrand, R.M. Hobbs, H.L. Janovjak, Journal of Molecular Biology 431 (2019) 3046–3055.","mla":"Tichy, Alexandra-Madelaine, et al. “Engineering Strategy and Vector Library for the Rapid Generation of Modular Light-Controlled Protein–Protein Interactions.” Journal of Molecular Biology, vol. 431, no. 17, Elsevier, 2019, pp. 3046–55, doi:10.1016/j.jmb.2019.05.033."},"date_published":"2019-08-09T00:00:00Z","type":"journal_article","abstract":[{"text":"Optogenetics enables the spatio-temporally precise control of cell and animal behavior. Many optogenetic tools are driven by light-controlled protein–protein interactions (PPIs) that are repurposed from natural light-sensitive domains (LSDs). Applying light-controlled PPIs to new target proteins is challenging because it is difficult to predict which of the many available LSDs, if any, will yield robust light regulation. As a consequence, fusion protein libraries need to be prepared and tested, but methods and platforms to facilitate this process are currently not available. Here, we developed a genetic engineering strategy and vector library for the rapid generation of light-controlled PPIs. The strategy permits fusing a target protein to multiple LSDs efficiently and in two orientations. The public and expandable library contains 29 vectors with blue, green or red light-responsive LSDs, many of which have been previously applied ex vivo and in vivo. We demonstrate the versatility of the approach and the necessity for sampling LSDs by generating light-activated caspase-9 (casp9) enzymes. Collectively, this work provides a new resource for optical regulation of a broad range of target proteins in cell and developmental biology.","lang":"eng"}],"issue":"17","title":"Engineering strategy and vector library for the rapid generation of modular light-controlled protein–protein interactions","status":"public","intvolume":" 431","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"6564","oa_version":"Preprint","month":"08","publication_identifier":{"issn":["00222836"],"eissn":["10898638"]},"isi":1,"quality_controlled":"1","main_file_link":[{"open_access":"1","url":"http://www.biorxiv.org/content/10.1101/583369v1"}],"external_id":{"isi":["000482872100002"]},"oa":1,"language":[{"iso":"eng"}],"doi":"10.1016/j.jmb.2019.05.033","publication_status":"published","publisher":"Elsevier","department":[{"_id":"HaJa"}],"year":"2019","date_created":"2019-06-16T21:59:14Z","date_updated":"2023-08-28T09:39:22Z","volume":431,"author":[{"full_name":"Tichy, Alexandra-Madelaine","last_name":"Tichy","first_name":"Alexandra-Madelaine","id":"29D8BB2C-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Gerrard, Elliot J.","first_name":"Elliot J.","last_name":"Gerrard"},{"full_name":"Legrand, Julien M.D.","last_name":"Legrand","first_name":"Julien M.D."},{"full_name":"Hobbs, Robin M.","last_name":"Hobbs","first_name":"Robin M."},{"id":"33BA6C30-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8023-9315","first_name":"Harald L","last_name":"Janovjak","full_name":"Janovjak, Harald L"}]},{"publication_identifier":{"issn":["09609822"]},"month":"06","oa":1,"main_file_link":[{"url":"https://doi.org/10.1016/j.cub.2019.03.035","open_access":"1"}],"external_id":{"isi":["000470902000023"],"pmid":["31163158"]},"quality_controlled":"1","isi":1,"doi":"10.1016/j.cub.2019.03.035","language":[{"iso":"eng"}],"pmid":1,"year":"2019","department":[{"_id":"SyCr"}],"publisher":"Elsevier","publication_status":"published","author":[{"full_name":"Cremer, Sylvia","orcid":"0000-0002-2193-3868","id":"2F64EC8C-F248-11E8-B48F-1D18A9856A87","last_name":"Cremer","first_name":"Sylvia"}],"volume":29,"date_created":"2019-06-09T21:59:10Z","date_updated":"2023-08-28T09:38:00Z","scopus_import":"1","article_processing_charge":"No","day":"03","citation":{"ama":"Cremer S. Social immunity in insects. Current Biology. 2019;29(11):R458-R463. doi:10.1016/j.cub.2019.03.035","apa":"Cremer, S. (2019). Social immunity in insects. Current Biology. Elsevier. https://doi.org/10.1016/j.cub.2019.03.035","ieee":"S. Cremer, “Social immunity in insects,” Current Biology, vol. 29, no. 11. Elsevier, pp. R458–R463, 2019.","ista":"Cremer S. 2019. Social immunity in insects. Current Biology. 29(11), R458–R463.","short":"S. Cremer, Current Biology 29 (2019) R458–R463.","mla":"Cremer, Sylvia. “Social Immunity in Insects.” Current Biology, vol. 29, no. 11, Elsevier, 2019, pp. R458–63, doi:10.1016/j.cub.2019.03.035.","chicago":"Cremer, Sylvia. “Social Immunity in Insects.” Current Biology. Elsevier, 2019. https://doi.org/10.1016/j.cub.2019.03.035."},"publication":"Current Biology","page":"R458-R463","article_type":"original","date_published":"2019-06-03T00:00:00Z","type":"journal_article","issue":"11","abstract":[{"lang":"eng","text":"When animals become sick, infected cells and an armada of activated immune cells attempt to eliminate the pathogen from the body. Once infectious particles have breached the body's physical barriers of the skin or gut lining, an initially local response quickly escalates into a systemic response, attracting mobile immune cells to the site of infection. These cells complement the initial, unspecific defense with a more specialized, targeted response. This can also provide long-term immune memory and protection against future infection. The cell-autonomous defenses of the infected cells are thus aided by the actions of recruited immune cells. These specialized cells are the most mobile cells in the body, constantly patrolling through the otherwise static tissue to detect incoming pathogens. Such constant immune surveillance means infections are noticed immediately and can be rapidly cleared from the body. Some immune cells also remove infected cells that have succumbed to infection. All this prevents pathogen replication and spread to healthy tissues. Although this may involve the sacrifice of some somatic tissue, this is typically replaced quickly. Particular care is, however, given to the reproductive organs, which should always remain disease free (immune privilege). "}],"_id":"6552","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","intvolume":" 29","title":"Social immunity in insects","status":"public","oa_version":"Published Version"},{"date_published":"2019-05-01T00:00:00Z","page":"1270-1334","citation":{"apa":"Bao, Z., Erdös, L., & Schnelli, K. (2019). Local single ring theorem on optimal scale. Annals of Probability. Institute of Mathematical Statistics. https://doi.org/10.1214/18-AOP1284","ieee":"Z. Bao, L. Erdös, and K. Schnelli, “Local single ring theorem on optimal scale,” Annals of Probability, vol. 47, no. 3. Institute of Mathematical Statistics, pp. 1270–1334, 2019.","ista":"Bao Z, Erdös L, Schnelli K. 2019. Local single ring theorem on optimal scale. Annals of Probability. 47(3), 1270–1334.","ama":"Bao Z, Erdös L, Schnelli K. Local single ring theorem on optimal scale. Annals of Probability. 2019;47(3):1270-1334. doi:10.1214/18-AOP1284","chicago":"Bao, Zhigang, László Erdös, and Kevin Schnelli. “Local Single Ring Theorem on Optimal Scale.” Annals of Probability. Institute of Mathematical Statistics, 2019. https://doi.org/10.1214/18-AOP1284.","short":"Z. Bao, L. Erdös, K. Schnelli, Annals of Probability 47 (2019) 1270–1334.","mla":"Bao, Zhigang, et al. “Local Single Ring Theorem on Optimal Scale.” Annals of Probability, vol. 47, no. 3, Institute of Mathematical Statistics, 2019, pp. 1270–334, doi:10.1214/18-AOP1284."},"publication":"Annals of Probability","article_processing_charge":"No","day":"01","scopus_import":"1","oa_version":"Preprint","intvolume":" 47","title":"Local single ring theorem on optimal scale","status":"public","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"6511","issue":"3","abstract":[{"text":"Let U and V be two independent N by N random matrices that are distributed according to Haar measure on U(N). Let Σ be a nonnegative deterministic N by N matrix. The single ring theorem [Ann. of Math. (2) 174 (2011) 1189–1217] asserts that the empirical eigenvalue distribution of the matrix X:=UΣV∗ converges weakly, in the limit of large N, to a deterministic measure which is supported on a single ring centered at the origin in ℂ. Within the bulk regime, that is, in the interior of the single ring, we establish the convergence of the empirical eigenvalue distribution on the optimal local scale of order N−1/2+ε and establish the optimal convergence rate. The same results hold true when U and V are Haar distributed on O(N).","lang":"eng"}],"type":"journal_article","language":[{"iso":"eng"}],"doi":"10.1214/18-AOP1284","project":[{"grant_number":"338804","_id":"258DCDE6-B435-11E9-9278-68D0E5697425","name":"Random matrices, universality and disordered quantum systems","call_identifier":"FP7"}],"isi":1,"quality_controlled":"1","external_id":{"isi":["000466616100003"],"arxiv":["1612.05920"]},"oa":1,"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1612.05920"}],"publication_identifier":{"issn":["00911798"]},"month":"05","volume":47,"date_updated":"2023-08-28T09:32:29Z","date_created":"2019-06-02T21:59:13Z","author":[{"full_name":"Bao, Zhigang","id":"442E6A6C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-3036-1475","first_name":"Zhigang","last_name":"Bao"},{"full_name":"Erdös, László","id":"4DBD5372-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5366-9603","first_name":"László","last_name":"Erdös"},{"orcid":"0000-0003-0954-3231","id":"434AD0AE-F248-11E8-B48F-1D18A9856A87","last_name":"Schnelli","first_name":"Kevin","full_name":"Schnelli, Kevin"}],"publisher":"Institute of Mathematical Statistics","department":[{"_id":"LaEr"}],"publication_status":"published","year":"2019","ec_funded":1},{"abstract":[{"lang":"eng","text":"Branching morphogenesis is a prototypical example of complex three-dimensional organ sculpting, required in multiple developmental settings to maximize the area of exchange surfaces. It requires, in particular, the coordinated growth of different cell types together with complex patterning to lead to robust macroscopic outputs. In recent years, novel multiscale quantitative biology approaches, together with biophysical modelling, have begun to shed new light of this topic. Here, we wish to review some of these recent developments, highlighting the generic design principles that can be abstracted across different branched organs, as well as the implications for the broader fields of stem cell, developmental and systems biology."}],"type":"journal_article","oa_version":"None","intvolume":" 60","status":"public","title":"Multiscale dynamics of branching morphogenesis","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"6559","article_processing_charge":"No","day":"01","scopus_import":"1","date_published":"2019-10-01T00:00:00Z","page":"99-105","article_type":"original","citation":{"chicago":"Hannezo, Edouard B, and Benjamin D. Simons. “Multiscale Dynamics of Branching Morphogenesis.” Current Opinion in Cell Biology. Elsevier, 2019. https://doi.org/10.1016/j.ceb.2019.04.008.","mla":"Hannezo, Edouard B., and Benjamin D. Simons. “Multiscale Dynamics of Branching Morphogenesis.” Current Opinion in Cell Biology, vol. 60, Elsevier, 2019, pp. 99–105, doi:10.1016/j.ceb.2019.04.008.","short":"E.B. Hannezo, B.D. Simons, Current Opinion in Cell Biology 60 (2019) 99–105.","ista":"Hannezo EB, Simons BD. 2019. Multiscale dynamics of branching morphogenesis. Current Opinion in Cell Biology. 60, 99–105.","ieee":"E. B. Hannezo and B. D. Simons, “Multiscale dynamics of branching morphogenesis,” Current Opinion in Cell Biology, vol. 60. Elsevier, pp. 99–105, 2019.","apa":"Hannezo, E. B., & Simons, B. D. (2019). Multiscale dynamics of branching morphogenesis. Current Opinion in Cell Biology. Elsevier. https://doi.org/10.1016/j.ceb.2019.04.008","ama":"Hannezo EB, Simons BD. Multiscale dynamics of branching morphogenesis. Current Opinion in Cell Biology. 2019;60:99-105. doi:10.1016/j.ceb.2019.04.008"},"publication":"Current Opinion in Cell Biology","volume":60,"date_created":"2019-06-16T21:59:12Z","date_updated":"2023-08-28T09:38:57Z","author":[{"first_name":"Edouard B","last_name":"Hannezo","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6005-1561","full_name":"Hannezo, Edouard B"},{"full_name":"Simons, Benjamin D.","first_name":"Benjamin D.","last_name":"Simons"}],"publisher":"Elsevier","department":[{"_id":"EdHa"}],"publication_status":"published","pmid":1,"year":"2019","publication_identifier":{"issn":["09550674"],"eissn":["18790410"]},"month":"10","language":[{"iso":"eng"}],"doi":"10.1016/j.ceb.2019.04.008","quality_controlled":"1","isi":1,"external_id":{"pmid":["31181348"],"isi":["000486545800014"]}},{"date_created":"2019-06-18T13:54:34Z","date_updated":"2023-08-28T12:20:53Z","volume":13,"author":[{"id":"43C61214-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5013-2843","first_name":"Maria","last_name":"Ibáñez","full_name":"Ibáñez, Maria"},{"first_name":"Aziz","last_name":"Genç","full_name":"Genç, Aziz"},{"full_name":"Hasler, Roger","first_name":"Roger","last_name":"Hasler"},{"full_name":"Liu, Yu","orcid":"0000-0001-7313-6740","id":"2A70014E-F248-11E8-B48F-1D18A9856A87","last_name":"Liu","first_name":"Yu"},{"full_name":"Dobrozhan, Oleksandr","last_name":"Dobrozhan","first_name":"Oleksandr"},{"first_name":"Olga","last_name":"Nazarenko","full_name":"Nazarenko, Olga"},{"last_name":"Mata","first_name":"María de la","full_name":"Mata, María de la"},{"full_name":"Arbiol, Jordi","last_name":"Arbiol","first_name":"Jordi"},{"last_name":"Cabot","first_name":"Andreu","full_name":"Cabot, Andreu"},{"full_name":"Kovalenko, Maksym V.","first_name":"Maksym V.","last_name":"Kovalenko"}],"publication_status":"published","publisher":"American Chemical Society","department":[{"_id":"MaIb"}],"year":"2019","pmid":1,"file_date_updated":"2020-07-14T12:47:33Z","ec_funded":1,"language":[{"iso":"eng"}],"doi":"10.1021/acsnano.9b00346","isi":1,"quality_controlled":"1","project":[{"grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425","name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020"}],"oa":1,"external_id":{"pmid":["31185159"],"isi":["000473248300043"]},"month":"06","publication_identifier":{"issn":["1936-0851"],"eissn":["1936-086X"]},"oa_version":"Published Version","file":[{"creator":"dernst","content_type":"application/pdf","file_size":8628690,"access_level":"open_access","file_name":"2019_ACSNano_Ibanez.pdf","date_updated":"2020-07-14T12:47:33Z","date_created":"2019-07-16T14:17:09Z","file_id":"6644","relation":"main_file"}],"title":"Tuning transport properties in thermoelectric nanocomposites through inorganic ligands and heterostructured building blocks","ddc":["540"],"status":"public","intvolume":" 13","_id":"6566","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","abstract":[{"text":"Methodologies that involve the use of nanoparticles as “artificial atoms” to rationally build materials in a bottom-up fashion are particularly well-suited to control the matter at the nanoscale. Colloidal synthetic routes allow for an exquisite control over such “artificial atoms” in terms of size, shape, and crystal phase as well as core and surface compositions. We present here a bottom-up approach to produce Pb–Ag–K–S–Te nanocomposites, which is a highly promising system for thermoelectric energy conversion. First, we developed a high-yield and scalable colloidal synthesis route to uniform lead sulfide (PbS) nanorods, whose tips are made of silver sulfide (Ag2S). We then took advantage of the large surface-to-volume ratio to introduce a p-type dopant (K) by replacing native organic ligands with K2Te. Upon thermal consolidation, K2Te-surface modified PbS–Ag2S nanorods yield p-type doped nanocomposites with PbTe and PbS as major phases and Ag2S and Ag2Te as embedded nanoinclusions. Thermoelectric characterization of such consolidated nanosolids showed a high thermoelectric figure-of-merit of 1 at 620 K.","lang":"eng"}],"issue":"6","type":"journal_article","date_published":"2019-06-25T00:00:00Z","article_type":"original","page":"6572-6580","publication":"ACS Nano","citation":{"apa":"Ibáñez, M., Genç, A., Hasler, R., Liu, Y., Dobrozhan, O., Nazarenko, O., … Kovalenko, M. V. (2019). Tuning transport properties in thermoelectric nanocomposites through inorganic ligands and heterostructured building blocks. ACS Nano. American Chemical Society. https://doi.org/10.1021/acsnano.9b00346","ieee":"M. Ibáñez et al., “Tuning transport properties in thermoelectric nanocomposites through inorganic ligands and heterostructured building blocks,” ACS Nano, vol. 13, no. 6. American Chemical Society, pp. 6572–6580, 2019.","ista":"Ibáñez M, Genç A, Hasler R, Liu Y, Dobrozhan O, Nazarenko O, Mata M de la, Arbiol J, Cabot A, Kovalenko MV. 2019. Tuning transport properties in thermoelectric nanocomposites through inorganic ligands and heterostructured building blocks. ACS Nano. 13(6), 6572–6580.","ama":"Ibáñez M, Genç A, Hasler R, et al. Tuning transport properties in thermoelectric nanocomposites through inorganic ligands and heterostructured building blocks. ACS Nano. 2019;13(6):6572-6580. doi:10.1021/acsnano.9b00346","chicago":"Ibáñez, Maria, Aziz Genç, Roger Hasler, Yu Liu, Oleksandr Dobrozhan, Olga Nazarenko, María de la Mata, Jordi Arbiol, Andreu Cabot, and Maksym V. Kovalenko. “Tuning Transport Properties in Thermoelectric Nanocomposites through Inorganic Ligands and Heterostructured Building Blocks.” ACS Nano. American Chemical Society, 2019. https://doi.org/10.1021/acsnano.9b00346.","short":"M. Ibáñez, A. Genç, R. Hasler, Y. Liu, O. Dobrozhan, O. Nazarenko, M. de la Mata, J. Arbiol, A. Cabot, M.V. Kovalenko, ACS Nano 13 (2019) 6572–6580.","mla":"Ibáñez, Maria, et al. “Tuning Transport Properties in Thermoelectric Nanocomposites through Inorganic Ligands and Heterostructured Building Blocks.” ACS Nano, vol. 13, no. 6, American Chemical Society, 2019, pp. 6572–80, doi:10.1021/acsnano.9b00346."},"day":"25","article_processing_charge":"Yes (in subscription journal)","has_accepted_license":"1","keyword":["colloidal nanoparticles","asymmetric nanoparticles","inorganic ligands","heterostructures","catalyst assisted growth","nanocomposites","thermoelectrics"],"scopus_import":"1"},{"volume":9,"date_updated":"2023-08-28T12:26:51Z","date_created":"2019-07-07T21:59:19Z","author":[{"last_name":"Nguyen","first_name":"Chi Huu","full_name":"Nguyen, Chi Huu"},{"last_name":"Glüxam","first_name":"Tobias","full_name":"Glüxam, Tobias"},{"last_name":"Schlerka","first_name":"Angela","full_name":"Schlerka, Angela"},{"id":"2ED6B14C-F248-11E8-B48F-1D18A9856A87","last_name":"Bauer","first_name":"Katharina","full_name":"Bauer, Katharina"},{"last_name":"Grandits","first_name":"Alexander M.","full_name":"Grandits, Alexander M."},{"last_name":"Hackl","first_name":"Hubert","full_name":"Hackl, Hubert"},{"last_name":"Dovey","first_name":"Oliver","full_name":"Dovey, Oliver"},{"full_name":"Zöchbauer-Müller, Sabine","last_name":"Zöchbauer-Müller","first_name":"Sabine"},{"full_name":"Cooper, Jonathan L.","first_name":"Jonathan L.","last_name":"Cooper"},{"last_name":"Vassiliou","first_name":"George S.","full_name":"Vassiliou, George S."},{"first_name":"Dagmar","last_name":"Stoiber","full_name":"Stoiber, Dagmar"},{"full_name":"Wieser, Rotraud","first_name":"Rotraud","last_name":"Wieser"},{"full_name":"Heller, Gerwin","first_name":"Gerwin","last_name":"Heller"}],"publisher":"Nature Publishing Group","department":[{"_id":"PreCl"}],"publication_status":"published","year":"2019","file_date_updated":"2020-07-14T12:47:34Z","article_number":"9139","language":[{"iso":"eng"}],"doi":"10.1038/s41598-019-45579-0","quality_controlled":"1","isi":1,"external_id":{"isi":["000472597400042"]},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"month":"06","oa_version":"Published Version","file":[{"relation":"main_file","file_id":"6623","checksum":"3283522fffadf4b5fc8c7adfe3ba4564","date_created":"2019-07-08T15:15:28Z","date_updated":"2020-07-14T12:47:34Z","access_level":"open_access","file_name":"nature_2019_Nguyen.pdf","content_type":"application/pdf","file_size":2017352,"creator":"kschuh"}],"intvolume":" 9","status":"public","title":"SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness","ddc":["576"],"_id":"6607","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","issue":"1","abstract":[{"text":"Acute myeloid leukemia (AML) is a heterogeneous disease with respect to its genetic and molecular basis and to patients´ outcome. Clinical, cytogenetic, and mutational data are used to classify patients into risk groups with different survival, however, within-group heterogeneity is still an issue. Here, we used a robust likelihood-based survival modeling approach and publicly available gene expression data to identify a minimal number of genes whose combined expression values were prognostic of overall survival. The resulting gene expression signature (4-GES) consisted of 4 genes (SOCS2, IL2RA, NPDC1, PHGDH), predicted patient survival as an independent prognostic parameter in several cohorts of AML patients (total, 1272 patients), and further refined prognostication based on the European Leukemia Net classification. An oncogenic role of the top scoring gene in this signature, SOCS2, was investigated using MLL-AF9 and Flt3-ITD/NPM1c driven mouse models of AML. SOCS2 promoted leukemogenesis as well as the abundance, quiescence, and activity of AML stem cells. Overall, the 4-GES represents a highly discriminating prognostic parameter in AML, whose clinical applicability is greatly enhanced by its small number of genes. The newly established role of SOCS2 in leukemia aggressiveness and stemness raises the possibility that the signature might even be exploitable therapeutically.","lang":"eng"}],"type":"journal_article","date_published":"2019-06-24T00:00:00Z","citation":{"chicago":"Nguyen, Chi Huu, Tobias Glüxam, Angela Schlerka, Katharina Bauer, Alexander M. Grandits, Hubert Hackl, Oliver Dovey, et al. “SOCS2 Is Part of a Highly Prognostic 4-Gene Signature in AML and Promotes Disease Aggressiveness.” Scientific Reports. Nature Publishing Group, 2019. https://doi.org/10.1038/s41598-019-45579-0.","mla":"Nguyen, Chi Huu, et al. “SOCS2 Is Part of a Highly Prognostic 4-Gene Signature in AML and Promotes Disease Aggressiveness.” Scientific Reports, vol. 9, no. 1, 9139, Nature Publishing Group, 2019, doi:10.1038/s41598-019-45579-0.","short":"C.H. Nguyen, T. Glüxam, A. Schlerka, K. Bauer, A.M. Grandits, H. Hackl, O. Dovey, S. Zöchbauer-Müller, J.L. Cooper, G.S. Vassiliou, D. Stoiber, R. Wieser, G. Heller, Scientific Reports 9 (2019).","ista":"Nguyen CH, Glüxam T, Schlerka A, Bauer K, Grandits AM, Hackl H, Dovey O, Zöchbauer-Müller S, Cooper JL, Vassiliou GS, Stoiber D, Wieser R, Heller G. 2019. SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness. Scientific Reports. 9(1), 9139.","apa":"Nguyen, C. H., Glüxam, T., Schlerka, A., Bauer, K., Grandits, A. M., Hackl, H., … Heller, G. (2019). SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness. Scientific Reports. Nature Publishing Group. https://doi.org/10.1038/s41598-019-45579-0","ieee":"C. H. Nguyen et al., “SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness,” Scientific Reports, vol. 9, no. 1. Nature Publishing Group, 2019.","ama":"Nguyen CH, Glüxam T, Schlerka A, et al. SOCS2 is part of a highly prognostic 4-gene signature in AML and promotes disease aggressiveness. Scientific Reports. 2019;9(1). doi:10.1038/s41598-019-45579-0"},"publication":"Scientific Reports","has_accepted_license":"1","article_processing_charge":"No","day":"24","scopus_import":"1"},{"date_published":"2019-06-27T00:00:00Z","publication":"Nature","citation":{"short":"S. Barzanjeh, E. Redchenko, M. Peruzzo, M. Wulf, D. Lewis, G.M. Arnold, J.M. Fink, Nature 570 (2019) 480–483.","mla":"Barzanjeh, Shabir, et al. “Stationary Entangled Radiation from Micromechanical Motion.” Nature, vol. 570, Nature Publishing Group, 2019, pp. 480–83, doi:10.1038/s41586-019-1320-2.","chicago":"Barzanjeh, Shabir, Elena Redchenko, Matilda Peruzzo, Matthias Wulf, Dylan Lewis, Georg M Arnold, and Johannes M Fink. “Stationary Entangled Radiation from Micromechanical Motion.” Nature. Nature Publishing Group, 2019. https://doi.org/10.1038/s41586-019-1320-2.","ama":"Barzanjeh S, Redchenko E, Peruzzo M, et al. Stationary entangled radiation from micromechanical motion. Nature. 2019;570:480-483. doi:10.1038/s41586-019-1320-2","apa":"Barzanjeh, S., Redchenko, E., Peruzzo, M., Wulf, M., Lewis, D., Arnold, G. M., & Fink, J. M. (2019). Stationary entangled radiation from micromechanical motion. Nature. Nature Publishing Group. https://doi.org/10.1038/s41586-019-1320-2","ieee":"S. Barzanjeh et al., “Stationary entangled radiation from micromechanical motion,” Nature, vol. 570. Nature Publishing Group, pp. 480–483, 2019.","ista":"Barzanjeh S, Redchenko E, Peruzzo M, Wulf M, Lewis D, Arnold GM, Fink JM. 2019. Stationary entangled radiation from micromechanical motion. Nature. 570, 480–483."},"page":"480-483","day":"27","article_processing_charge":"No","scopus_import":"1","oa_version":"Preprint","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"6609","status":"public","title":"Stationary entangled radiation from micromechanical motion","intvolume":" 570","abstract":[{"lang":"eng","text":"Mechanical systems facilitate the development of a hybrid quantum technology comprising electrical, optical, atomic and acoustic degrees of freedom1, and entanglement is essential to realize quantum-enabled devices. Continuous-variable entangled fields—known as Einstein–Podolsky–Rosen (EPR) states—are spatially separated two-mode squeezed states that can be used for quantum teleportation and quantum communication2. In the optical domain, EPR states are typically generated using nondegenerate optical amplifiers3, and at microwave frequencies Josephson circuits can serve as a nonlinear medium4,5,6. An outstanding goal is to deterministically generate and distribute entangled states with a mechanical oscillator, which requires a carefully arranged balance between excitation, cooling and dissipation in an ultralow noise environment. Here we observe stationary emission of path-entangled microwave radiation from a parametrically driven 30-micrometre-long silicon nanostring oscillator, squeezing the joint field operators of two thermal modes by 3.40 decibels below the vacuum level. The motion of this micromechanical system correlates up to 50 photons per second per hertz, giving rise to a quantum discord that is robust with respect to microwave noise7. Such generalized quantum correlations of separable states are important for quantum-enhanced detection8 and provide direct evidence of the non-classical nature of the mechanical oscillator without directly measuring its state9. This noninvasive measurement scheme allows to infer information about otherwise inaccessible objects, with potential implications for sensing, open-system dynamics and fundamental tests of quantum gravity. In the future, similar on-chip devices could be used to entangle subsystems on very different energy scales, such as microwave and optical photons."}],"type":"journal_article","doi":"10.1038/s41586-019-1320-2","acknowledged_ssus":[{"_id":"NanoFab"}],"language":[{"iso":"eng"}],"oa":1,"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1809.05865"}],"external_id":{"arxiv":["1809.05865"],"isi":["000472860000042"]},"isi":1,"quality_controlled":"1","project":[{"name":"Hybrid Optomechanical Technologies","call_identifier":"H2020","grant_number":"732894","_id":"257EB838-B435-11E9-9278-68D0E5697425"},{"name":"A Fiber Optic Transceiver for Superconducting Qubits","call_identifier":"H2020","_id":"26336814-B435-11E9-9278-68D0E5697425","grant_number":"758053"},{"_id":"258047B6-B435-11E9-9278-68D0E5697425","grant_number":"707438","call_identifier":"H2020","name":"Microwave-to-Optical Quantum Link: Quantum Teleportation and Quantum Illumination with cavity Optomechanics"},{"name":"Coherent on-chip conversion of superconducting qubit signals from microwaves to optical frequencies","_id":"2671EB66-B435-11E9-9278-68D0E5697425"}],"month":"06","author":[{"full_name":"Barzanjeh, Shabir","orcid":"0000-0003-0415-1423","id":"2D25E1F6-F248-11E8-B48F-1D18A9856A87","last_name":"Barzanjeh","first_name":"Shabir"},{"full_name":"Redchenko, Elena","first_name":"Elena","last_name":"Redchenko","id":"2C21D6E8-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Peruzzo, Matilda","id":"3F920B30-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3415-4628","first_name":"Matilda","last_name":"Peruzzo"},{"full_name":"Wulf, Matthias","orcid":"0000-0001-6613-1378","id":"45598606-F248-11E8-B48F-1D18A9856A87","last_name":"Wulf","first_name":"Matthias"},{"last_name":"Lewis","first_name":"Dylan","full_name":"Lewis, Dylan"},{"last_name":"Arnold","first_name":"Georg M","orcid":"0000-0003-1397-7876","id":"3770C838-F248-11E8-B48F-1D18A9856A87","full_name":"Arnold, Georg M"},{"full_name":"Fink, Johannes M","id":"4B591CBA-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-8112-028X","first_name":"Johannes M","last_name":"Fink"}],"date_updated":"2023-08-28T12:29:56Z","date_created":"2019-07-07T21:59:20Z","volume":570,"year":"2019","publication_status":"published","department":[{"_id":"JoFi"}],"publisher":"Nature Publishing Group","ec_funded":1},{"ec_funded":1,"file_date_updated":"2020-07-14T12:47:34Z","article_number":"138","author":[{"full_name":"Shehu, Yekini","first_name":"Yekini","last_name":"Shehu","id":"3FC7CB58-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-9224-7139"}],"volume":74,"date_updated":"2023-08-28T12:26:22Z","date_created":"2019-06-29T10:11:30Z","year":"2019","publisher":"Springer","department":[{"_id":"VlKo"}],"publication_status":"published","publication_identifier":{"eissn":["1420-9012"],"issn":["1422-6383"]},"month":"12","doi":"10.1007/s00025-019-1061-4","language":[{"iso":"eng"}],"oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"external_id":{"isi":["000473237500002"],"arxiv":["2101.09068"]},"project":[{"grant_number":"616160","_id":"25FBA906-B435-11E9-9278-68D0E5697425","name":"Discrete Optimization in Computer Vision: Theory and Practice","call_identifier":"FP7"},{"name":"IST Austria Open Access Fund","_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854"}],"quality_controlled":"1","isi":1,"issue":"4","abstract":[{"lang":"eng","text":"It is well known that many problems in image recovery, signal processing, and machine learning can be modeled as finding zeros of the sum of maximal monotone and Lipschitz continuous monotone operators. Many papers have studied forward-backward splitting methods for finding zeros of the sum of two monotone operators in Hilbert spaces. Most of the proposed splitting methods in the literature have been proposed for the sum of maximal monotone and inverse-strongly monotone operators in Hilbert spaces. In this paper, we consider splitting methods for finding zeros of the sum of maximal monotone operators and Lipschitz continuous monotone operators in Banach spaces. We obtain weak and strong convergence results for the zeros of the sum of maximal monotone and Lipschitz continuous monotone operators in Banach spaces. Many already studied problems in the literature can be considered as special cases of this paper."}],"type":"journal_article","oa_version":"Published Version","file":[{"date_updated":"2020-07-14T12:47:34Z","date_created":"2019-07-03T15:20:40Z","checksum":"c6d18cb1e16fc0c36a0e0f30b4ebbc2d","relation":"main_file","file_id":"6605","file_size":466942,"content_type":"application/pdf","creator":"kschuh","file_name":"Springer_2019_Shehu.pdf","access_level":"open_access"}],"_id":"6596","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","intvolume":" 74","title":"Convergence results of forward-backward algorithms for sum of monotone operators in Banach spaces","status":"public","ddc":["000"],"article_processing_charge":"Yes (via OA deal)","has_accepted_license":"1","day":"01","scopus_import":"1","date_published":"2019-12-01T00:00:00Z","citation":{"chicago":"Shehu, Yekini. “Convergence Results of Forward-Backward Algorithms for Sum of Monotone Operators in Banach Spaces.” Results in Mathematics. Springer, 2019. https://doi.org/10.1007/s00025-019-1061-4.","short":"Y. Shehu, Results in Mathematics 74 (2019).","mla":"Shehu, Yekini. “Convergence Results of Forward-Backward Algorithms for Sum of Monotone Operators in Banach Spaces.” Results in Mathematics, vol. 74, no. 4, 138, Springer, 2019, doi:10.1007/s00025-019-1061-4.","ieee":"Y. Shehu, “Convergence results of forward-backward algorithms for sum of monotone operators in Banach spaces,” Results in Mathematics, vol. 74, no. 4. Springer, 2019.","apa":"Shehu, Y. (2019). Convergence results of forward-backward algorithms for sum of monotone operators in Banach spaces. Results in Mathematics. Springer. https://doi.org/10.1007/s00025-019-1061-4","ista":"Shehu Y. 2019. Convergence results of forward-backward algorithms for sum of monotone operators in Banach spaces. Results in Mathematics. 74(4), 138.","ama":"Shehu Y. Convergence results of forward-backward algorithms for sum of monotone operators in Banach spaces. Results in Mathematics. 2019;74(4). doi:10.1007/s00025-019-1061-4"},"publication":"Results in Mathematics","article_type":"original"},{"date_published":"2019-07-27T00:00:00Z","article_type":"review","page":"12-25","publication":"Cell","citation":{"mla":"Hannezo, Edouard B., and Carl-Philipp J. Heisenberg. “Mechanochemical Feedback Loops in Development and Disease.” Cell, vol. 178, no. 1, Elsevier, 2019, pp. 12–25, doi:10.1016/j.cell.2019.05.052.","short":"E.B. Hannezo, C.-P.J. Heisenberg, Cell 178 (2019) 12–25.","chicago":"Hannezo, Edouard B, and Carl-Philipp J Heisenberg. “Mechanochemical Feedback Loops in Development and Disease.” Cell. Elsevier, 2019. https://doi.org/10.1016/j.cell.2019.05.052.","ama":"Hannezo EB, Heisenberg C-PJ. Mechanochemical feedback loops in development and disease. Cell. 2019;178(1):12-25. doi:10.1016/j.cell.2019.05.052","ista":"Hannezo EB, Heisenberg C-PJ. 2019. Mechanochemical feedback loops in development and disease. Cell. 178(1), 12–25.","apa":"Hannezo, E. B., & Heisenberg, C.-P. J. (2019). Mechanochemical feedback loops in development and disease. Cell. Elsevier. https://doi.org/10.1016/j.cell.2019.05.052","ieee":"E. B. Hannezo and C.-P. J. Heisenberg, “Mechanochemical feedback loops in development and disease,” Cell, vol. 178, no. 1. Elsevier, pp. 12–25, 2019."},"day":"27","article_processing_charge":"No","scopus_import":"1","oa_version":"Published Version","title":"Mechanochemical feedback loops in development and disease","status":"public","intvolume":" 178","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","_id":"6601","abstract":[{"lang":"eng","text":"There is increasing evidence that both mechanical and biochemical signals play important roles in development and disease. The development of complex organisms, in particular, has been proposed to rely on the feedback between mechanical and biochemical patterning events. This feedback occurs at the molecular level via mechanosensation but can also arise as an emergent property of the system at the cellular and tissue level. In recent years, dynamic changes in tissue geometry, flow, rheology, and cell fate specification have emerged as key platforms of mechanochemical feedback loops in multiple processes. Here, we review recent experimental and theoretical advances in understanding how these feedbacks function in development and disease."}],"issue":"1","type":"journal_article","language":[{"iso":"eng"}],"doi":"10.1016/j.cell.2019.05.052","quality_controlled":"1","isi":1,"project":[{"call_identifier":"H2020","name":"Interaction and feedback between cell mechanics and fate specification in vertebrate gastrulation","_id":"260F1432-B435-11E9-9278-68D0E5697425","grant_number":"742573"},{"grant_number":"P31639","_id":"268294B6-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Active mechano-chemical description of the cell cytoskeleton"}],"main_file_link":[{"open_access":"1","url":"https://doi.org/10.1016/j.cell.2019.05.052"}],"oa":1,"external_id":{"isi":["000473002700005"],"pmid":["31251912"]},"month":"07","publication_identifier":{"issn":["00928674"]},"date_updated":"2023-08-28T12:25:21Z","date_created":"2019-06-30T21:59:11Z","volume":178,"author":[{"full_name":"Hannezo, Edouard B","last_name":"Hannezo","first_name":"Edouard B","orcid":"0000-0001-6005-1561","id":"3A9DB764-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","first_name":"Carl-Philipp J"}],"publication_status":"published","publisher":"Elsevier","department":[{"_id":"CaHe"},{"_id":"EdHa"}],"year":"2019","pmid":1,"ec_funded":1},{"date_published":"2019-11-01T00:00:00Z","page":"635–726","article_type":"original","citation":{"ama":"Fischer JL. The choice of representative volumes in the approximation of effective properties of random materials. Archive for Rational Mechanics and Analysis. 2019;234(2):635–726. doi:10.1007/s00205-019-01400-w","ista":"Fischer JL. 2019. The choice of representative volumes in the approximation of effective properties of random materials. Archive for Rational Mechanics and Analysis. 234(2), 635–726.","apa":"Fischer, J. L. (2019). The choice of representative volumes in the approximation of effective properties of random materials. Archive for Rational Mechanics and Analysis. Springer. https://doi.org/10.1007/s00205-019-01400-w","ieee":"J. L. Fischer, “The choice of representative volumes in the approximation of effective properties of random materials,” Archive for Rational Mechanics and Analysis, vol. 234, no. 2. Springer, pp. 635–726, 2019.","mla":"Fischer, Julian L. “The Choice of Representative Volumes in the Approximation of Effective Properties of Random Materials.” Archive for Rational Mechanics and Analysis, vol. 234, no. 2, Springer, 2019, pp. 635–726, doi:10.1007/s00205-019-01400-w.","short":"J.L. Fischer, Archive for Rational Mechanics and Analysis 234 (2019) 635–726.","chicago":"Fischer, Julian L. “The Choice of Representative Volumes in the Approximation of Effective Properties of Random Materials.” Archive for Rational Mechanics and Analysis. Springer, 2019. https://doi.org/10.1007/s00205-019-01400-w."},"publication":"Archive for Rational Mechanics and Analysis","has_accepted_license":"1","article_processing_charge":"Yes (via OA deal)","day":"01","scopus_import":"1","file":[{"creator":"kschuh","file_size":1377659,"content_type":"application/pdf","access_level":"open_access","file_name":"Springer_2019_Fischer.pdf","checksum":"4cff75fa6addb0770991ad9c474ab404","date_updated":"2020-07-14T12:47:34Z","date_created":"2019-07-08T15:56:47Z","file_id":"6626","relation":"main_file"}],"oa_version":"Published Version","intvolume":" 234","title":"The choice of representative volumes in the approximation of effective properties of random materials","ddc":["500"],"status":"public","_id":"6617","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","issue":"2","abstract":[{"text":"The effective large-scale properties of materials with random heterogeneities on a small scale are typically determined by the method of representative volumes: a sample of the random material is chosen—the representative volume—and its effective properties are computed by the cell formula. Intuitively, for a fixed sample size it should be possible to increase the accuracy of the method by choosing a material sample which captures the statistical properties of the material particularly well; for example, for a composite material consisting of two constituents, one would select a representative volume in which the volume fraction of the constituents matches closely with their volume fraction in the overall material. Inspired by similar attempts in materials science, Le Bris, Legoll and Minvielle have designed a selection approach for representative volumes which performs remarkably well in numerical examples of linear materials with moderate contrast. In the present work, we provide a rigorous analysis of this selection approach for representative volumes in the context of stochastic homogenization of linear elliptic equations. In particular, we prove that the method essentially never performs worse than a random selection of the material sample and may perform much better if the selection criterion for the material samples is chosen suitably.","lang":"eng"}],"type":"journal_article","language":[{"iso":"eng"}],"doi":"10.1007/s00205-019-01400-w","project":[{"_id":"B67AFEDC-15C9-11EA-A837-991A96BB2854","name":"IST Austria Open Access Fund"}],"isi":1,"quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"external_id":{"isi":["000482386000006"],"arxiv":["1807.00834"]},"publication_identifier":{"issn":["0003-9527"],"eissn":["1432-0673"]},"month":"11","volume":234,"date_updated":"2023-08-28T12:31:21Z","date_created":"2019-07-07T21:59:23Z","author":[{"full_name":"Fischer, Julian L","first_name":"Julian L","last_name":"Fischer","id":"2C12A0B0-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0479-558X"}],"publisher":"Springer","department":[{"_id":"JuFi"}],"publication_status":"published","year":"2019","file_date_updated":"2020-07-14T12:47:34Z"},{"has_accepted_license":"1","article_processing_charge":"No","day":"07","scopus_import":"1","date_published":"2019-06-07T00:00:00Z","citation":{"chicago":"Glanc, Matous, Matyas Fendrych, and Jiří Friml. “PIN2 Polarity Establishment in Arabidopsis in the Absence of an Intact Cytoskeleton.” Biomolecules. MDPI, 2019. https://doi.org/10.3390/biom9060222.","short":"M. Glanc, M. Fendrych, J. Friml, Biomolecules 9 (2019).","mla":"Glanc, Matous, et al. “PIN2 Polarity Establishment in Arabidopsis in the Absence of an Intact Cytoskeleton.” Biomolecules, vol. 9, no. 6, 222, MDPI, 2019, doi:10.3390/biom9060222.","apa":"Glanc, M., Fendrych, M., & Friml, J. (2019). PIN2 polarity establishment in arabidopsis in the absence of an intact cytoskeleton. Biomolecules. MDPI. https://doi.org/10.3390/biom9060222","ieee":"M. Glanc, M. Fendrych, and J. Friml, “PIN2 polarity establishment in arabidopsis in the absence of an intact cytoskeleton,” Biomolecules, vol. 9, no. 6. MDPI, 2019.","ista":"Glanc M, Fendrych M, Friml J. 2019. PIN2 polarity establishment in arabidopsis in the absence of an intact cytoskeleton. Biomolecules. 9(6), 222.","ama":"Glanc M, Fendrych M, Friml J. PIN2 polarity establishment in arabidopsis in the absence of an intact cytoskeleton. Biomolecules. 2019;9(6). doi:10.3390/biom9060222"},"publication":"Biomolecules","issue":"6","abstract":[{"text":"Cell polarity is crucial for the coordinated development of all multicellular organisms. In plants, this is exemplified by the PIN-FORMED (PIN) efflux carriers of the phytohormone auxin: The polar subcellular localization of the PINs is instructive to the directional intercellular auxin transport, and thus to a plethora of auxin-regulated growth and developmental processes. Despite its importance, the regulation of PIN polar subcellular localization remains poorly understood. Here, we have employed advanced live-cell imaging techniques to study the roles of microtubules and actin microfilaments in the establishment of apical polar localization of PIN2 in the epidermis of the Arabidopsis root meristem. We report that apical PIN2 polarity requires neither intact actin microfilaments nor microtubules, suggesting that the primary spatial cue for polar PIN distribution is likely independent of cytoskeleton-guided endomembrane trafficking.","lang":"eng"}],"type":"journal_article","file":[{"access_level":"open_access","file_name":"biomolecules-2019-Matous.pdf","content_type":"application/pdf","file_size":1066773,"creator":"kschuh","relation":"main_file","file_id":"6625","checksum":"1ce1bd36038fe5381057a1bcc6760083","date_updated":"2020-07-14T12:47:34Z","date_created":"2019-07-08T15:46:32Z"}],"oa_version":"Published Version","intvolume":" 9","ddc":["580"],"title":"PIN2 polarity establishment in arabidopsis in the absence of an intact cytoskeleton","status":"public","_id":"6611","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","month":"06","language":[{"iso":"eng"}],"acknowledged_ssus":[{"_id":"Bio"}],"doi":"10.3390/biom9060222","project":[{"name":"Tracing Evolution of Auxin Transport and Polarity in Plants","call_identifier":"H2020","grant_number":"742985","_id":"261099A6-B435-11E9-9278-68D0E5697425"}],"quality_controlled":"1","isi":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"external_id":{"isi":["000475301500018"],"pmid":["31181636"]},"oa":1,"ec_funded":1,"file_date_updated":"2020-07-14T12:47:34Z","article_number":"222","volume":9,"date_created":"2019-07-07T21:59:21Z","date_updated":"2023-08-28T12:30:24Z","author":[{"last_name":"Glanc","first_name":"Matous","orcid":"0000-0003-0619-7783","id":"1AE1EA24-02D0-11E9-9BAA-DAF4881429F2","full_name":"Glanc, Matous"},{"full_name":"Fendrych, Matyas","first_name":"Matyas","last_name":"Fendrych","id":"43905548-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-9767-8699"},{"last_name":"Friml","first_name":"Jiří","orcid":"0000-0002-8302-7596","id":"4159519E-F248-11E8-B48F-1D18A9856A87","full_name":"Friml, Jiří"}],"publisher":"MDPI","department":[{"_id":"JiFr"}],"publication_status":"published","pmid":1,"year":"2019"},{"oa_version":"Preprint","status":"public","title":"On a certain non-split cubic surface","intvolume":" 62","_id":"6620","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","abstract":[{"text":"This paper establishes an asymptotic formula with a power-saving error term for the number of rational points of bounded height on the singular cubic surface of ℙ3ℚ given by the following equation 𝑥0(𝑥21+𝑥22)−𝑥33=0 in agreement with the Manin-Peyre conjectures.\r\n","lang":"eng"}],"issue":"12","type":"journal_article","date_published":"2019-12-01T00:00:00Z","article_type":"original","page":"2435–2446","publication":"Science China Mathematics","citation":{"ama":"De La Bretèche R, Destagnol KN, Liu J, Wu J, Zhao Y. On a certain non-split cubic surface. Science China Mathematics. 2019;62(12):2435–2446. doi:10.1007/s11425-018-9543-8","apa":"De La Bretèche, R., Destagnol, K. N., Liu, J., Wu, J., & Zhao, Y. (2019). On a certain non-split cubic surface. Science China Mathematics. Springer. https://doi.org/10.1007/s11425-018-9543-8","ieee":"R. De La Bretèche, K. N. Destagnol, J. Liu, J. Wu, and Y. Zhao, “On a certain non-split cubic surface,” Science China Mathematics, vol. 62, no. 12. Springer, pp. 2435–2446, 2019.","ista":"De La Bretèche R, Destagnol KN, Liu J, Wu J, Zhao Y. 2019. On a certain non-split cubic surface. Science China Mathematics. 62(12), 2435–2446.","short":"R. De La Bretèche, K.N. Destagnol, J. Liu, J. Wu, Y. Zhao, Science China Mathematics 62 (2019) 2435–2446.","mla":"De La Bretèche, Régis, et al. “On a Certain Non-Split Cubic Surface.” Science China Mathematics, vol. 62, no. 12, Springer, 2019, pp. 2435–2446, doi:10.1007/s11425-018-9543-8.","chicago":"De La Bretèche, Régis, Kevin N Destagnol, Jianya Liu, Jie Wu, and Yongqiang Zhao. “On a Certain Non-Split Cubic Surface.” Science China Mathematics. Springer, 2019. https://doi.org/10.1007/s11425-018-9543-8."},"day":"01","article_processing_charge":"No","scopus_import":"1","date_created":"2019-07-07T21:59:25Z","date_updated":"2023-08-28T12:32:20Z","volume":62,"author":[{"last_name":"De La Bretèche","first_name":"Régis","full_name":"De La Bretèche, Régis"},{"last_name":"Destagnol","first_name":"Kevin N","id":"44DDECBC-F248-11E8-B48F-1D18A9856A87","full_name":"Destagnol, Kevin N"},{"first_name":"Jianya","last_name":"Liu","full_name":"Liu, Jianya"},{"full_name":"Wu, Jie","last_name":"Wu","first_name":"Jie"},{"full_name":"Zhao, Yongqiang","last_name":"Zhao","first_name":"Yongqiang"}],"publication_status":"published","publisher":"Springer","department":[{"_id":"TiBr"}],"year":"2019","language":[{"iso":"eng"}],"doi":"10.1007/s11425-018-9543-8","isi":1,"quality_controlled":"1","oa":1,"external_id":{"arxiv":["1709.09476"],"isi":["000509102200001"]},"main_file_link":[{"url":"https://arxiv.org/abs/1709.09476","open_access":"1"}],"month":"12","publication_identifier":{"issn":["16747283"]}},{"acknowledgement":"The authors would like to thank to Tiago Paixao and Nick Barton for useful comments and advice.","year":"2019","publisher":"Wiley","department":[{"_id":"NiBa"}],"publication_status":"published","author":[{"full_name":"Trubenova, Barbora","orcid":"0000-0002-6873-2967","id":"42302D54-F248-11E8-B48F-1D18A9856A87","last_name":"Trubenova","first_name":"Barbora"},{"first_name":"Martin ","last_name":"Krejca","full_name":"Krejca, Martin "},{"full_name":"Lehre, Per Kristian","first_name":"Per Kristian","last_name":"Lehre"},{"last_name":"Kötzing","first_name":"Timo","full_name":"Kötzing, Timo"}],"volume":73,"date_created":"2019-07-14T21:59:20Z","date_updated":"2023-08-29T06:31:14Z","ec_funded":1,"file_date_updated":"2020-07-14T12:47:34Z","license":"https://creativecommons.org/licenses/by-nc-nd/4.0/","tmp":{"name":"Creative Commons Attribution-NonCommercial-NoDerivatives 4.0 International (CC BY-NC-ND 4.0)","legal_code_url":"https://creativecommons.org/licenses/by-nc-nd/4.0/legalcode","short":"CC BY-NC-ND (4.0)","image":"/images/cc_by_nc_nd.png"},"oa":1,"external_id":{"isi":["000474031600001"]},"project":[{"grant_number":"704172","_id":"25AEDD42-B435-11E9-9278-68D0E5697425","call_identifier":"H2020","name":"Rate of Adaptation in Changing Environment"},{"name":"Speed of Adaptation in Population Genetics and Evolutionary Computation","call_identifier":"FP7","grant_number":"618091","_id":"25B1EC9E-B435-11E9-9278-68D0E5697425"}],"isi":1,"quality_controlled":"1","doi":"10.1111/evo.13784","language":[{"iso":"eng"}],"month":"07","_id":"6637","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","intvolume":" 73","status":"public","ddc":["576"],"title":"Surfing on the seascape: Adaptation in a changing environment","oa_version":"Published Version","file":[{"file_id":"6643","relation":"main_file","date_updated":"2020-07-14T12:47:34Z","date_created":"2019-07-16T06:08:31Z","checksum":"9831ca65def2d62498c7b08338b6d237","file_name":"2019_Evolution_TrubenovaBarbora.pdf","access_level":"open_access","creator":"apreinsp","file_size":815416,"content_type":"application/pdf"}],"type":"journal_article","issue":"7","abstract":[{"lang":"eng","text":"The environment changes constantly at various time scales and, in order to survive, species need to keep adapting. Whether these species succeed in avoiding extinction is a major evolutionary question. Using a multilocus evolutionary model of a mutation‐limited population adapting under strong selection, we investigate the effects of the frequency of environmental fluctuations on adaptation. Our results rely on an “adaptive‐walk” approximation and use mathematical methods from evolutionary computation theory to investigate the interplay between fluctuation frequency, the similarity of environments, and the number of loci contributing to adaptation. First, we assume a linear additive fitness function, but later generalize our results to include several types of epistasis. We show that frequent environmental changes prevent populations from reaching a fitness peak, but they may also prevent the large fitness loss that occurs after a single environmental change. Thus, the population can survive, although not thrive, in a wide range of conditions. Furthermore, we show that in a frequently changing environment, the similarity of threats that a population faces affects the level of adaptation that it is able to achieve. We check and supplement our analytical results with simulations."}],"citation":{"ista":"Trubenova B, Krejca M, Lehre PK, Kötzing T. 2019. Surfing on the seascape: Adaptation in a changing environment. Evolution. 73(7), 1356–1374.","apa":"Trubenova, B., Krejca, M., Lehre, P. K., & Kötzing, T. (2019). Surfing on the seascape: Adaptation in a changing environment. Evolution. Wiley. https://doi.org/10.1111/evo.13784","ieee":"B. Trubenova, M. Krejca, P. K. Lehre, and T. Kötzing, “Surfing on the seascape: Adaptation in a changing environment,” Evolution, vol. 73, no. 7. Wiley, pp. 1356–1374, 2019.","ama":"Trubenova B, Krejca M, Lehre PK, Kötzing T. Surfing on the seascape: Adaptation in a changing environment. Evolution. 2019;73(7):1356-1374. doi:10.1111/evo.13784","chicago":"Trubenova, Barbora, Martin Krejca, Per Kristian Lehre, and Timo Kötzing. “Surfing on the Seascape: Adaptation in a Changing Environment.” Evolution. Wiley, 2019. https://doi.org/10.1111/evo.13784.","mla":"Trubenova, Barbora, et al. “Surfing on the Seascape: Adaptation in a Changing Environment.” Evolution, vol. 73, no. 7, Wiley, 2019, pp. 1356–74, doi:10.1111/evo.13784.","short":"B. Trubenova, M. Krejca, P.K. Lehre, T. Kötzing, Evolution 73 (2019) 1356–1374."},"publication":"Evolution","page":"1356-1374","article_type":"original","date_published":"2019-07-01T00:00:00Z","scopus_import":"1","article_processing_charge":"Yes (via OA deal)","has_accepted_license":"1","day":"01"},{"month":"06","main_file_link":[{"url":"https://arxiv.org/abs/1612.06926","open_access":"1"}],"oa":1,"external_id":{"isi":["000472541600004"],"arxiv":["1612.06926"]},"quality_controlled":"1","isi":1,"project":[{"call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme","grant_number":"291734","_id":"25681D80-B435-11E9-9278-68D0E5697425"}],"doi":"10.12775/TMNA.2019.008","language":[{"iso":"eng"}],"ec_funded":1,"year":"2019","publication_status":"published","department":[{"_id":"HeEd"}],"publisher":"Akademicka Platforma Czasopism","author":[{"full_name":"Akopyan, Arseniy","first_name":"Arseniy","last_name":"Akopyan","id":"430D2C90-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-2548-617X"},{"full_name":"Hubard, Alfredo","last_name":"Hubard","first_name":"Alfredo"},{"first_name":"Roman","last_name":"Karasev","full_name":"Karasev, Roman"}],"date_updated":"2023-08-29T06:32:48Z","date_created":"2019-07-14T21:59:19Z","volume":53,"scopus_import":"1","day":"01","article_processing_charge":"No","publication":"Topological Methods in Nonlinear Analysis","citation":{"ama":"Akopyan A, Hubard A, Karasev R. Lower and upper bounds for the waists of different spaces. Topological Methods in Nonlinear Analysis. 2019;53(2):457-490. doi:10.12775/TMNA.2019.008","ista":"Akopyan A, Hubard A, Karasev R. 2019. Lower and upper bounds for the waists of different spaces. Topological Methods in Nonlinear Analysis. 53(2), 457–490.","apa":"Akopyan, A., Hubard, A., & Karasev, R. (2019). Lower and upper bounds for the waists of different spaces. Topological Methods in Nonlinear Analysis. Akademicka Platforma Czasopism. https://doi.org/10.12775/TMNA.2019.008","ieee":"A. Akopyan, A. Hubard, and R. Karasev, “Lower and upper bounds for the waists of different spaces,” Topological Methods in Nonlinear Analysis, vol. 53, no. 2. Akademicka Platforma Czasopism, pp. 457–490, 2019.","mla":"Akopyan, Arseniy, et al. “Lower and Upper Bounds for the Waists of Different Spaces.” Topological Methods in Nonlinear Analysis, vol. 53, no. 2, Akademicka Platforma Czasopism, 2019, pp. 457–90, doi:10.12775/TMNA.2019.008.","short":"A. Akopyan, A. Hubard, R. Karasev, Topological Methods in Nonlinear Analysis 53 (2019) 457–490.","chicago":"Akopyan, Arseniy, Alfredo Hubard, and Roman Karasev. “Lower and Upper Bounds for the Waists of Different Spaces.” Topological Methods in Nonlinear Analysis. Akademicka Platforma Czasopism, 2019. https://doi.org/10.12775/TMNA.2019.008."},"page":"457-490","date_published":"2019-06-01T00:00:00Z","type":"journal_article","abstract":[{"text":"In this paper we prove several new results around Gromov's waist theorem. We give a simple proof of Vaaler's theorem on sections of the unit cube using the Borsuk-Ulam-Crofton technique, consider waists of real and complex projective spaces, flat tori, convex bodies in Euclidean space; and establish waist-type results in terms of the Hausdorff measure.","lang":"eng"}],"issue":"2","_id":"6634","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","status":"public","title":"Lower and upper bounds for the waists of different spaces","intvolume":" 53","oa_version":"Preprint"},{"date_published":"2019-11-01T00:00:00Z","page":"3201-3207","publication":"Discrete Mathematics","citation":{"apa":"Silva, A., Arroyo Guevara, A. M., Richter, B., & Lee, O. (2019). Graphs with at most one crossing. Discrete Mathematics. Elsevier. https://doi.org/10.1016/j.disc.2019.06.031","ieee":"A. Silva, A. M. Arroyo Guevara, B. Richter, and O. Lee, “Graphs with at most one crossing,” Discrete Mathematics, vol. 342, no. 11. Elsevier, pp. 3201–3207, 2019.","ista":"Silva A, Arroyo Guevara AM, Richter B, Lee O. 2019. Graphs with at most one crossing. Discrete Mathematics. 342(11), 3201–3207.","ama":"Silva A, Arroyo Guevara AM, Richter B, Lee O. Graphs with at most one crossing. Discrete Mathematics. 2019;342(11):3201-3207. doi:10.1016/j.disc.2019.06.031","chicago":"Silva, André , Alan M Arroyo Guevara, Bruce Richter, and Orlando Lee. “Graphs with at Most One Crossing.” Discrete Mathematics. Elsevier, 2019. https://doi.org/10.1016/j.disc.2019.06.031.","short":"A. Silva, A.M. Arroyo Guevara, B. Richter, O. Lee, Discrete Mathematics 342 (2019) 3201–3207.","mla":"Silva, André, et al. “Graphs with at Most One Crossing.” Discrete Mathematics, vol. 342, no. 11, Elsevier, 2019, pp. 3201–07, doi:10.1016/j.disc.2019.06.031."},"day":"01","article_processing_charge":"No","scopus_import":"1","oa_version":"Preprint","status":"public","title":"Graphs with at most one crossing","intvolume":" 342","_id":"6638","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","abstract":[{"text":"The crossing number of a graph G is the least number of crossings over all possible drawings of G. We present a structural characterization of graphs with crossing number one.","lang":"eng"}],"issue":"11","type":"journal_article","language":[{"iso":"eng"}],"doi":"10.1016/j.disc.2019.06.031","isi":1,"quality_controlled":"1","project":[{"_id":"26366136-B435-11E9-9278-68D0E5697425","name":"Reglas de Conectividad funcional en el hipocampo"},{"name":"ISTplus - Postdoctoral Fellowships","call_identifier":"H2020","grant_number":"754411","_id":"260C2330-B435-11E9-9278-68D0E5697425"}],"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1901.09955"}],"external_id":{"isi":["000486358100025"],"arxiv":["1901.09955"]},"oa":1,"month":"11","publication_identifier":{"issn":["0012-365X"]},"date_updated":"2023-08-29T06:31:41Z","date_created":"2019-07-14T21:59:20Z","volume":342,"author":[{"last_name":"Silva","first_name":"André ","full_name":"Silva, André "},{"last_name":"Arroyo Guevara","first_name":"Alan M","orcid":"0000-0003-2401-8670","id":"3207FDC6-F248-11E8-B48F-1D18A9856A87","full_name":"Arroyo Guevara, Alan M"},{"full_name":"Richter, Bruce","last_name":"Richter","first_name":"Bruce"},{"full_name":"Lee, Orlando","first_name":"Orlando","last_name":"Lee"}],"publication_status":"published","publisher":"Elsevier","department":[{"_id":"UlWa"}],"year":"2019","ec_funded":1},{"abstract":[{"lang":"eng","text":"The spatiotemporal organization of cell divisions constitutes an integral part in the development of multicellular organisms, and mis-regulation of cell divisions can lead to severe developmental defects. Cell divisions have an important morphogenetic function in development by regulating growth and shape acquisition of developing tissues, and, conversely, tissue morphogenesis is known to affect both the rate and orientation of cell divisions. Moreover, cell divisions are associated with an extensive reorganization of the cytoskeleton and adhesion apparatus in the dividing cells that in turn can affect large-scale tissue rheological properties. Thus, the interplay between cell divisions and tissue morphogenesis plays a key role in embryo and tissue morphogenesis."}],"type":"journal_article","author":[{"full_name":"Godard, Benoit G","first_name":"Benoit G","last_name":"Godard","id":"33280250-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Heisenberg, Carl-Philipp J","orcid":"0000-0002-0912-4566","id":"39427864-F248-11E8-B48F-1D18A9856A87","last_name":"Heisenberg","first_name":"Carl-Philipp J"}],"date_updated":"2023-08-29T06:33:14Z","date_created":"2019-07-14T21:59:17Z","volume":60,"oa_version":"None","_id":"6631","year":"2019","user_id":"4359f0d1-fa6c-11eb-b949-802e58b17ae8","publication_status":"published","status":"public","title":"Cell division and tissue mechanics","department":[{"_id":"CaHe"}],"publisher":"Elsevier","intvolume":" 60","day":"01","month":"10","publication_identifier":{"issn":["0955-0674"]},"article_processing_charge":"No","scopus_import":"1","date_published":"2019-10-01T00:00:00Z","doi":"10.1016/j.ceb.2019.05.007","language":[{"iso":"eng"}],"publication":"Current Opinion in Cell Biology","external_id":{"isi":["000486545800016"]},"citation":{"short":"B.G. Godard, C.-P.J. Heisenberg, Current Opinion in Cell Biology 60 (2019) 114–120.","mla":"Godard, Benoit G., and Carl-Philipp J. Heisenberg. “Cell Division and Tissue Mechanics.” Current Opinion in Cell Biology, vol. 60, Elsevier, 2019, pp. 114–20, doi:10.1016/j.ceb.2019.05.007.","chicago":"Godard, Benoit G, and Carl-Philipp J Heisenberg. “Cell Division and Tissue Mechanics.” Current Opinion in Cell Biology. Elsevier, 2019. https://doi.org/10.1016/j.ceb.2019.05.007.","ama":"Godard BG, Heisenberg C-PJ. Cell division and tissue mechanics. Current Opinion in Cell Biology. 2019;60:114-120. doi:10.1016/j.ceb.2019.05.007","apa":"Godard, B. G., & Heisenberg, C.-P. J. (2019). Cell division and tissue mechanics. Current Opinion in Cell Biology. Elsevier. https://doi.org/10.1016/j.ceb.2019.05.007","ieee":"B. G. Godard and C.-P. J. Heisenberg, “Cell division and tissue mechanics,” Current Opinion in Cell Biology, vol. 60. Elsevier, pp. 114–120, 2019.","ista":"Godard BG, Heisenberg C-PJ. 2019. Cell division and tissue mechanics. Current Opinion in Cell Biology. 60, 114–120."},"quality_controlled":"1","isi":1,"page":"114-120"}]