---
_id: '6658'
abstract:
- lang: eng
text: 'New genes are a major source of novelties, and a disproportionate amount
of them are known to show testis expression in later phases of male gametogenesis
in different groups such as mammals and plants. Here, we propose that this enhanced
expression is a consequence of haploid selection during the latter stages of male
gametogenesis. Because emerging adaptive mutations will be fixed faster if their
phenotypes are expressed by haploid rather than diploid genotypes, new genes with
advantageous functions arising during this unique stage of development have a
better chance to become fixed. To test this hypothesis, expression levels of genes
of differing evolutionary age were examined at various stages of Drosophila spermatogenesis.
We found, consistent with a model based on haploid selection, that new Drosophila
genes are both expressed in later haploid phases of spermatogenesis and harbor
a significant enrichment of adaptive mutations. Additionally, the observed overexpression
of new genes in the latter phases of spermatogenesis was limited to the autosomes.
Because all male cells exhibit hemizygous expression for X-linked genes (and therefore
effectively haploid), there is no expectation that selection acting on late spermatogenesis
will have a different effect on X-linked genes in comparison to initial diploid
phases. Together, our proposed hypothesis and the analyzed data suggest that natural
selection in haploid cells elucidates several aspects of the origin of new genes
by explaining the general prevalence of their testis expression, and a parsimonious
solution for new alleles to avoid being lost by genetic drift or pseudogenization. '
article_processing_charge: No
author:
- first_name: Julia
full_name: Raices, Julia
id: 3EE67F22-F248-11E8-B48F-1D18A9856A87
last_name: Raices
- first_name: Paulo
full_name: Otto, Paulo
last_name: Otto
- first_name: Maria
full_name: Vibranovski, Maria
last_name: Vibranovski
citation:
ama: Raices J, Otto P, Vibranovski M. Haploid selection drives new gene male germline
expression. Genome Research. 2019;29(7):1115-1122. doi:10.1101/gr.238824.118
apa: Raices, J., Otto, P., & Vibranovski, M. (2019). Haploid selection drives
new gene male germline expression. Genome Research. CSH Press. https://doi.org/10.1101/gr.238824.118
chicago: Raices, Julia, Paulo Otto, and Maria Vibranovski. “Haploid Selection Drives
New Gene Male Germline Expression.” Genome Research. CSH Press, 2019. https://doi.org/10.1101/gr.238824.118.
ieee: J. Raices, P. Otto, and M. Vibranovski, “Haploid selection drives new gene
male germline expression,” Genome Research, vol. 29, no. 7. CSH Press,
pp. 1115–1122, 2019.
ista: Raices J, Otto P, Vibranovski M. 2019. Haploid selection drives new gene male
germline expression. Genome Research. 29(7), 1115–1122.
mla: Raices, Julia, et al. “Haploid Selection Drives New Gene Male Germline Expression.”
Genome Research, vol. 29, no. 7, CSH Press, 2019, pp. 1115–22, doi:10.1101/gr.238824.118.
short: J. Raices, P. Otto, M. Vibranovski, Genome Research 29 (2019) 1115–1122.
date_created: 2019-07-21T21:59:15Z
date_published: 2019-07-01T00:00:00Z
date_updated: 2023-08-29T06:35:05Z
day: '01'
ddc:
- '576'
department:
- _id: BeVi
doi: 10.1101/gr.238824.118
external_id:
isi:
- '000473730600007'
file:
- access_level: open_access
checksum: 4636f03a6750f90b88bf2bc3eb9d71ae
content_type: application/pdf
creator: apreinsp
date_created: 2019-07-24T08:05:56Z
date_updated: 2020-07-14T12:47:35Z
file_id: '6670'
file_name: 2019_GenomeResearch_Raices.pdf
file_size: 2319022
relation: main_file
file_date_updated: 2020-07-14T12:47:35Z
has_accepted_license: '1'
intvolume: ' 29'
isi: 1
issue: '7'
language:
- iso: eng
license: https://creativecommons.org/licenses/by-nc/4.0/
month: '07'
oa: 1
oa_version: Published Version
page: 1115-1122
publication: Genome Research
publication_status: published
publisher: CSH Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Haploid selection drives new gene male germline expression
tmp:
image: /images/cc_by_nc.png
legal_code_url: https://creativecommons.org/licenses/by-nc/4.0/legalcode
name: Creative Commons Attribution-NonCommercial 4.0 International (CC BY-NC 4.0)
short: CC BY-NC (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 29
year: '2019'
...
---
_id: '6650'
abstract:
- lang: eng
text: We propose a novel technique for the automatic design of molds to cast highly
complex shapes. The technique generates composite, two-piece molds. Each mold
piece is made up of a hard plastic shell and a flexible silicone part. Thanks
to the thin, soft, and smartly shaped silicone part, which is kept in place by
a hard plastic shell, we can cast objects of unprecedented complexity. An innovative
algorithm based on a volumetric analysis defines the layout of the internal cuts
in the silicone mold part. Our approach can robustly handle thin protruding features
and intertwined topologies that have caused previous methods to fail. We compare
our results with state of the art techniques, and we demonstrate the casting of
shapes with extremely complex geometry.
article_number: '110'
article_processing_charge: No
author:
- first_name: Thomas
full_name: Alderighi, Thomas
last_name: Alderighi
- first_name: Luigi
full_name: Malomo, Luigi
last_name: Malomo
- first_name: Daniela
full_name: Giorgi, Daniela
last_name: Giorgi
- first_name: Bernd
full_name: Bickel, Bernd
id: 49876194-F248-11E8-B48F-1D18A9856A87
last_name: Bickel
orcid: 0000-0001-6511-9385
- first_name: Paolo
full_name: Cignoni, Paolo
last_name: Cignoni
- first_name: Nico
full_name: Pietroni, Nico
last_name: Pietroni
citation:
ama: Alderighi T, Malomo L, Giorgi D, Bickel B, Cignoni P, Pietroni N. Volume-aware
design of composite molds. ACM Transactions on Graphics. 2019;38(4). doi:10.1145/3306346.3322981
apa: Alderighi, T., Malomo, L., Giorgi, D., Bickel, B., Cignoni, P., & Pietroni,
N. (2019). Volume-aware design of composite molds. ACM Transactions on Graphics.
ACM. https://doi.org/10.1145/3306346.3322981
chicago: Alderighi, Thomas, Luigi Malomo, Daniela Giorgi, Bernd Bickel, Paolo Cignoni,
and Nico Pietroni. “Volume-Aware Design of Composite Molds.” ACM Transactions
on Graphics. ACM, 2019. https://doi.org/10.1145/3306346.3322981.
ieee: T. Alderighi, L. Malomo, D. Giorgi, B. Bickel, P. Cignoni, and N. Pietroni,
“Volume-aware design of composite molds,” ACM Transactions on Graphics,
vol. 38, no. 4. ACM, 2019.
ista: Alderighi T, Malomo L, Giorgi D, Bickel B, Cignoni P, Pietroni N. 2019. Volume-aware
design of composite molds. ACM Transactions on Graphics. 38(4), 110.
mla: Alderighi, Thomas, et al. “Volume-Aware Design of Composite Molds.” ACM
Transactions on Graphics, vol. 38, no. 4, 110, ACM, 2019, doi:10.1145/3306346.3322981.
short: T. Alderighi, L. Malomo, D. Giorgi, B. Bickel, P. Cignoni, N. Pietroni, ACM
Transactions on Graphics 38 (2019).
date_created: 2019-07-19T06:18:15Z
date_published: 2019-07-01T00:00:00Z
date_updated: 2023-08-29T06:35:52Z
day: '01'
ddc:
- '000'
department:
- _id: BeBi
doi: 10.1145/3306346.3322981
ec_funded: 1
external_id:
isi:
- '000475740600084'
file:
- access_level: open_access
checksum: b4562af94672b44d2a501046427412af
content_type: application/pdf
creator: dernst
date_created: 2019-07-19T06:18:53Z
date_updated: 2020-07-14T12:47:35Z
file_id: '6651'
file_name: 2019_ACM_Alderighi_AuthorVersion.pdf
file_size: 74316182
relation: main_file
file_date_updated: 2020-07-14T12:47:35Z
has_accepted_license: '1'
intvolume: ' 38'
isi: 1
issue: '4'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
project:
- _id: 24F9549A-B435-11E9-9278-68D0E5697425
call_identifier: H2020
grant_number: '715767'
name: 'MATERIALIZABLE: Intelligent fabrication-oriented Computational Design and
Modeling'
publication: ACM Transactions on Graphics
publication_identifier:
issn:
- 0730-0301
publication_status: published
publisher: ACM
quality_controlled: '1'
related_material:
link:
- description: YouTube Video
relation: supplementary_material
url: https://youtu.be/SO349S8-x_w
scopus_import: '1'
status: public
title: Volume-aware design of composite molds
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 38
year: '2019'
...
---
_id: '6717'
abstract:
- lang: eng
text: With the recent publication by Silpe and Bassler (2019), considering phage
detection of a bacterial quorum-sensing (QS) autoinducer, we now have as many
as five examples of phage-associated intercellular communication (Table 1). Each
potentially involves ecological inferences by phages as to concentrations of surrounding
phage-infected or uninfected bacteria. While the utility of phage detection of
bacterial QS molecules may at first glance appear to be straightforward, we suggest
in this commentary that the underlying ecological explanation is unlikely to be
simple.
article_number: '1171'
article_processing_charge: Yes (via OA deal)
author:
- first_name: Claudia
full_name: Igler, Claudia
id: 46613666-F248-11E8-B48F-1D18A9856A87
last_name: Igler
- first_name: Stephen T.
full_name: Abedon, Stephen T.
last_name: Abedon
citation:
ama: 'Igler C, Abedon ST. Commentary: A host-produced quorum-sensing autoinducer
controls a phage lysis-lysogeny decision. Frontiers in Microbiology. 2019;10.
doi:10.3389/fmicb.2019.01171'
apa: 'Igler, C., & Abedon, S. T. (2019). Commentary: A host-produced quorum-sensing
autoinducer controls a phage lysis-lysogeny decision. Frontiers in Microbiology.
Frontiers. https://doi.org/10.3389/fmicb.2019.01171'
chicago: 'Igler, Claudia, and Stephen T. Abedon. “Commentary: A Host-Produced Quorum-Sensing
Autoinducer Controls a Phage Lysis-Lysogeny Decision.” Frontiers in Microbiology.
Frontiers, 2019. https://doi.org/10.3389/fmicb.2019.01171.'
ieee: 'C. Igler and S. T. Abedon, “Commentary: A host-produced quorum-sensing autoinducer
controls a phage lysis-lysogeny decision,” Frontiers in Microbiology, vol.
10. Frontiers, 2019.'
ista: 'Igler C, Abedon ST. 2019. Commentary: A host-produced quorum-sensing autoinducer
controls a phage lysis-lysogeny decision. Frontiers in Microbiology. 10, 1171.'
mla: 'Igler, Claudia, and Stephen T. Abedon. “Commentary: A Host-Produced Quorum-Sensing
Autoinducer Controls a Phage Lysis-Lysogeny Decision.” Frontiers in Microbiology,
vol. 10, 1171, Frontiers, 2019, doi:10.3389/fmicb.2019.01171.'
short: C. Igler, S.T. Abedon, Frontiers in Microbiology 10 (2019).
date_created: 2019-07-28T21:59:18Z
date_published: 2019-06-03T00:00:00Z
date_updated: 2023-08-29T06:41:20Z
day: '03'
ddc:
- '570'
department:
- _id: CaGu
doi: 10.3389/fmicb.2019.01171
external_id:
isi:
- '000470131200001'
file:
- access_level: open_access
checksum: 317a06067e9a8e717bb55f23e0d77ba7
content_type: application/pdf
creator: apreinsp
date_created: 2019-07-29T07:51:54Z
date_updated: 2020-07-14T12:47:38Z
file_id: '6722'
file_name: 2019_Frontiers_Igler.pdf
file_size: 246151
relation: main_file
file_date_updated: 2020-07-14T12:47:38Z
has_accepted_license: '1'
intvolume: ' 10'
isi: 1
language:
- iso: eng
license: https://creativecommons.org/licenses/by/4.0/
month: '06'
oa: 1
oa_version: Published Version
project:
- _id: 251EE76E-B435-11E9-9278-68D0E5697425
grant_number: '24573'
name: Design principles underlying genetic switch architecture (DOC Fellowship)
publication: Frontiers in Microbiology
publication_status: published
publisher: Frontiers
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Commentary: A host-produced quorum-sensing autoinducer controls a phage lysis-lysogeny
decision'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 10
year: '2019'
...
---
_id: '6680'
abstract:
- lang: eng
text: This paper analyzes how partial selfing in a large source population influences
its ability to colonize a new habitat via the introduction of a few founder individuals.
Founders experience inbreeding depression due to partially recessive deleterious
alleles as well as maladaptation to the new environment due to selection on a
large number of additive loci. I first introduce a simplified version of the Inbreeding
History Model (Kelly, 2007) in order to characterize mutation‐selection balance
in a large, partially selfing source population under selection involving multiple
non‐identical loci. I then use individual‐based simulations to study the eco‐evolutionary
dynamics of founders establishing in the new habitat under a model of hard selection.
The study explores how selfing rate shapes establishment probabilities of founders
via effects on both inbreeding depression and adaptability to the new environment,
and also distinguishes the effects of selfing on the initial fitness of founders
from its effects on the long‐term adaptive response of the populations they found.
A high rate of (but not complete) selfing is found to aid establishment over a
wide range of parameters, even in the absence of mate limitation. The sensitivity
of the results to assumptions about the nature of polygenic selection are discussed.
article_processing_charge: Yes (via OA deal)
author:
- first_name: Himani
full_name: Sachdeva, Himani
id: 42377A0A-F248-11E8-B48F-1D18A9856A87
last_name: Sachdeva
citation:
ama: Sachdeva H. Effect of partial selfing and polygenic selection on establishment
in a new habitat. Evolution. 2019;73(9):1729-1745. doi:10.1111/evo.13812
apa: Sachdeva, H. (2019). Effect of partial selfing and polygenic selection on establishment
in a new habitat. Evolution. Wiley. https://doi.org/10.1111/evo.13812
chicago: Sachdeva, Himani. “Effect of Partial Selfing and Polygenic Selection on
Establishment in a New Habitat.” Evolution. Wiley, 2019. https://doi.org/10.1111/evo.13812.
ieee: H. Sachdeva, “Effect of partial selfing and polygenic selection on establishment
in a new habitat,” Evolution, vol. 73, no. 9. Wiley, pp. 1729–1745, 2019.
ista: Sachdeva H. 2019. Effect of partial selfing and polygenic selection on establishment
in a new habitat. Evolution. 73(9), 1729–1745.
mla: Sachdeva, Himani. “Effect of Partial Selfing and Polygenic Selection on Establishment
in a New Habitat.” Evolution, vol. 73, no. 9, Wiley, 2019, pp. 1729–45,
doi:10.1111/evo.13812.
short: H. Sachdeva, Evolution 73 (2019) 1729–1745.
date_created: 2019-07-25T09:08:28Z
date_published: 2019-09-01T00:00:00Z
date_updated: 2023-08-29T06:43:58Z
day: '01'
ddc:
- '576'
department:
- _id: NiBa
doi: 10.1111/evo.13812
external_id:
isi:
- '000481300600001'
file:
- access_level: open_access
checksum: 772ce7035965153959b946a1033de1ca
content_type: application/pdf
creator: kschuh
date_created: 2019-09-17T10:56:27Z
date_updated: 2020-07-14T12:47:37Z
file_id: '6881'
file_name: 2019_Evolution_Sachdeva.pdf
file_size: 937573
relation: main_file
file_date_updated: 2020-07-14T12:47:37Z
has_accepted_license: '1'
intvolume: ' 73'
isi: 1
issue: '9'
language:
- iso: eng
month: '09'
oa: 1
oa_version: Published Version
page: 1729-1745
publication: Evolution
publication_identifier:
eissn:
- 1558-5646
issn:
- 0014-3820
publication_status: published
publisher: Wiley
quality_controlled: '1'
related_material:
record:
- id: '9802'
relation: research_data
status: public
scopus_import: '1'
status: public
title: Effect of partial selfing and polygenic selection on establishment in a new
habitat
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 73
year: '2019'
...
---
_id: '6710'
abstract:
- lang: eng
text: Sexual dimorphism in morphology, physiology or life history traits is common
in dioecious plants at reproductive maturity, but it is typically inconspicuous
or absent in juveniles. Although plants of different sexes probably begin to diverge
in gene expression both before their reproduction commences and before dimorphism
becomes readily apparent, to our knowledge transcriptome-wide differential gene
expression has yet to be demonstrated for any angiosperm species.
article_processing_charge: No
article_type: original
author:
- first_name: Guillaume
full_name: Cossard, Guillaume
last_name: Cossard
- first_name: Melissa A
full_name: Toups, Melissa A
id: 4E099E4E-F248-11E8-B48F-1D18A9856A87
last_name: Toups
orcid: 0000-0002-9752-7380
- first_name: 'John '
full_name: 'Pannell, John '
last_name: Pannell
citation:
ama: Cossard G, Toups MA, Pannell J. Sexual dimorphism and rapid turnover in gene
expression in pre-reproductive seedlings of a dioecious herb. Annals of botany.
2019;123(7):1119-1131. doi:10.1093/aob/mcy183
apa: Cossard, G., Toups, M. A., & Pannell, J. (2019). Sexual dimorphism and
rapid turnover in gene expression in pre-reproductive seedlings of a dioecious
herb. Annals of Botany. Oxford University Press. https://doi.org/10.1093/aob/mcy183
chicago: Cossard, Guillaume, Melissa A Toups, and John Pannell. “Sexual Dimorphism
and Rapid Turnover in Gene Expression in Pre-Reproductive Seedlings of a Dioecious
Herb.” Annals of Botany. Oxford University Press, 2019. https://doi.org/10.1093/aob/mcy183.
ieee: G. Cossard, M. A. Toups, and J. Pannell, “Sexual dimorphism and rapid turnover
in gene expression in pre-reproductive seedlings of a dioecious herb,” Annals
of botany, vol. 123, no. 7. Oxford University Press, pp. 1119–1131, 2019.
ista: Cossard G, Toups MA, Pannell J. 2019. Sexual dimorphism and rapid turnover
in gene expression in pre-reproductive seedlings of a dioecious herb. Annals of
botany. 123(7), 1119–1131.
mla: Cossard, Guillaume, et al. “Sexual Dimorphism and Rapid Turnover in Gene Expression
in Pre-Reproductive Seedlings of a Dioecious Herb.” Annals of Botany, vol.
123, no. 7, Oxford University Press, 2019, pp. 1119–31, doi:10.1093/aob/mcy183.
short: G. Cossard, M.A. Toups, J. Pannell, Annals of Botany 123 (2019) 1119–1131.
date_created: 2019-07-28T21:59:15Z
date_published: 2019-06-04T00:00:00Z
date_updated: 2023-08-29T06:42:22Z
day: '04'
department:
- _id: BeVi
doi: 10.1093/aob/mcy183
external_id:
isi:
- '000493043500004'
pmid:
- '30289430'
intvolume: ' 123'
isi: 1
issue: '7'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://doi.org/10.1093/aob/mcy183
month: '06'
oa: 1
oa_version: Published Version
page: 1119-1131
pmid: 1
publication: Annals of botany
publication_identifier:
eissn:
- 1095-8290
issn:
- 0305-7364
publication_status: published
publisher: Oxford University Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: Sexual dimorphism and rapid turnover in gene expression in pre-reproductive
seedlings of a dioecious herb
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 123
year: '2019'
...
---
_id: '9804'
abstract:
- lang: eng
text: Evolutionary studies are often limited by missing data that are critical to
understanding the history of selection. Selection experiments, which reproduce
rapid evolution under controlled conditions, are excellent tools to study how
genomes evolve under selection. Here we present a genomic dissection of the Longshanks
selection experiment, in which mice were selectively bred over 20 generations
for longer tibiae relative to body mass, resulting in 13% longer tibiae in two
replicates. We synthesized evolutionary theory, genome sequences and molecular
genetics to understand the selection response and found that it involved both
polygenic adaptation and discrete loci of major effect, with the strongest loci
tending to be selected in parallel between replicates. We show that selection
may favor de-repression of bone growth through inactivating two limb enhancers
of an inhibitor, Nkx3-2. Our integrative genomic analyses thus show that it is
possible to connect individual base-pair changes to the overall selection response.
article_processing_charge: No
author:
- first_name: João Pl
full_name: Castro, João Pl
last_name: Castro
- first_name: Michelle N.
full_name: Yancoskie, Michelle N.
last_name: Yancoskie
- first_name: Marta
full_name: Marchini, Marta
last_name: Marchini
- first_name: Stefanie
full_name: Belohlavy, Stefanie
id: 43FE426A-F248-11E8-B48F-1D18A9856A87
last_name: Belohlavy
orcid: 0000-0002-9849-498X
- first_name: Layla
full_name: Hiramatsu, Layla
last_name: Hiramatsu
- first_name: Marek
full_name: Kučka, Marek
last_name: Kučka
- first_name: William H.
full_name: Beluch, William H.
last_name: Beluch
- first_name: Ronald
full_name: Naumann, Ronald
last_name: Naumann
- first_name: Isabella
full_name: Skuplik, Isabella
last_name: Skuplik
- first_name: John
full_name: Cobb, John
last_name: Cobb
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Campbell
full_name: Rolian, Campbell
last_name: Rolian
- first_name: Yingguang Frank
full_name: Chan, Yingguang Frank
last_name: Chan
citation:
ama: 'Castro JP, Yancoskie MN, Marchini M, et al. Data from: An integrative genomic
analysis of the Longshanks selection experiment for longer limbs in mice. 2019.
doi:10.5061/dryad.0q2h6tk'
apa: 'Castro, J. P., Yancoskie, M. N., Marchini, M., Belohlavy, S., Hiramatsu, L.,
Kučka, M., … Chan, Y. F. (2019). Data from: An integrative genomic analysis of
the Longshanks selection experiment for longer limbs in mice. Dryad. https://doi.org/10.5061/dryad.0q2h6tk'
chicago: 'Castro, João Pl, Michelle N. Yancoskie, Marta Marchini, Stefanie Belohlavy,
Layla Hiramatsu, Marek Kučka, William H. Beluch, et al. “Data from: An Integrative
Genomic Analysis of the Longshanks Selection Experiment for Longer Limbs in Mice.”
Dryad, 2019. https://doi.org/10.5061/dryad.0q2h6tk.'
ieee: 'J. P. Castro et al., “Data from: An integrative genomic analysis of
the Longshanks selection experiment for longer limbs in mice.” Dryad, 2019.'
ista: 'Castro JP, Yancoskie MN, Marchini M, Belohlavy S, Hiramatsu L, Kučka M, Beluch
WH, Naumann R, Skuplik I, Cobb J, Barton NH, Rolian C, Chan YF. 2019. Data from:
An integrative genomic analysis of the Longshanks selection experiment for longer
limbs in mice, Dryad, 10.5061/dryad.0q2h6tk.'
mla: 'Castro, João Pl, et al. Data from: An Integrative Genomic Analysis of the
Longshanks Selection Experiment for Longer Limbs in Mice. Dryad, 2019, doi:10.5061/dryad.0q2h6tk.'
short: J.P. Castro, M.N. Yancoskie, M. Marchini, S. Belohlavy, L. Hiramatsu, M.
Kučka, W.H. Beluch, R. Naumann, I. Skuplik, J. Cobb, N.H. Barton, C. Rolian, Y.F.
Chan, (2019).
date_created: 2021-08-06T11:52:54Z
date_published: 2019-06-06T00:00:00Z
date_updated: 2023-08-29T06:41:51Z
day: '06'
department:
- _id: NiBa
doi: 10.5061/dryad.0q2h6tk
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.0q2h6tk
month: '06'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '6713'
relation: used_in_publication
status: public
status: public
title: 'Data from: An integrative genomic analysis of the Longshanks selection experiment
for longer limbs in mice'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2019'
...
---
_id: '9802'
abstract:
- lang: eng
text: This paper analyzes how partial selfing in a large source population influences
its ability to colonize a new habitat via the introduction of a few founder individuals.
Founders experience inbreeding depression due to partially recessive deleterious
alleles as well as maladaptation to the new environment due to selection on a
large number of additive loci. I first introduce a simplified version of the Inbreeding
History Model (Kelly, 2007) in order to characterize mutation-selection balance
in a large, partially selfing source population under selection involving multiple
non-identical loci. I then use individual-based simulations to study the eco-evolutionary
dynamics of founders establishing in the new habitat under a model of hard selection.
The study explores how selfing rate shapes establishment probabilities of founders
via effects on both inbreeding depression and adaptability to the new environment,
and also distinguishes the effects of selfing on the initial fitness of founders
from its effects on the long-term adaptive response of the populations they found.
A high rate of (but not complete) selfing is found to aid establishment over a
wide range of parameters, even in the absence of mate limitation. The sensitivity
of the results to assumptions about the nature of polygenic selection are discussed.
article_processing_charge: No
author:
- first_name: Himani
full_name: Sachdeva, Himani
id: 42377A0A-F248-11E8-B48F-1D18A9856A87
last_name: Sachdeva
citation:
ama: 'Sachdeva H. Data from: Effect of partial selfing and polygenic selection on
establishment in a new habitat. 2019. doi:10.5061/dryad.8tp0900'
apa: 'Sachdeva, H. (2019). Data from: Effect of partial selfing and polygenic selection
on establishment in a new habitat. Dryad. https://doi.org/10.5061/dryad.8tp0900'
chicago: 'Sachdeva, Himani. “Data from: Effect of Partial Selfing and Polygenic
Selection on Establishment in a New Habitat.” Dryad, 2019. https://doi.org/10.5061/dryad.8tp0900.'
ieee: 'H. Sachdeva, “Data from: Effect of partial selfing and polygenic selection
on establishment in a new habitat.” Dryad, 2019.'
ista: 'Sachdeva H. 2019. Data from: Effect of partial selfing and polygenic selection
on establishment in a new habitat, Dryad, 10.5061/dryad.8tp0900.'
mla: 'Sachdeva, Himani. Data from: Effect of Partial Selfing and Polygenic Selection
on Establishment in a New Habitat. Dryad, 2019, doi:10.5061/dryad.8tp0900.'
short: H. Sachdeva, (2019).
date_created: 2021-08-06T11:45:11Z
date_published: 2019-07-16T00:00:00Z
date_updated: 2023-08-29T06:43:57Z
day: '16'
department:
- _id: NiBa
doi: 10.5061/dryad.8tp0900
main_file_link:
- open_access: '1'
url: https://doi.org/10.5061/dryad.8tp0900
month: '07'
oa: 1
oa_version: Published Version
publisher: Dryad
related_material:
record:
- id: '6680'
relation: used_in_publication
status: public
status: public
title: 'Data from: Effect of partial selfing and polygenic selection on establishment
in a new habitat'
type: research_data_reference
user_id: 6785fbc1-c503-11eb-8a32-93094b40e1cf
year: '2019'
...
---
_id: '6756'
abstract:
- lang: eng
text: "We study the topology generated by the temperature fluctuations of the cosmic
microwave background (CMB) radiation, as quantified by the number of components
and holes, formally given by the Betti numbers, in the growing excursion sets.
We compare CMB maps observed by the Planck satellite with a thousand simulated
maps generated according to the ΛCDM paradigm with Gaussian distributed fluctuations.
The comparison is multi-scale, being performed on a sequence of degraded maps
with mean pixel separation ranging from 0.05 to 7.33°. The survey of the CMB over
\U0001D54A2 is incomplete due to obfuscation effects by bright point sources and
other extended foreground objects like our own galaxy. To deal with such situations,
where analysis in the presence of “masks” is of importance, we introduce the concept
of relative homology. The parametric χ2-test shows differences between observations
and simulations, yielding p-values at percent to less than permil levels roughly
between 2 and 7°, with the difference in the number of components and holes peaking
at more than 3σ sporadically at these scales. The highest observed deviation between
the observations and simulations for b0 and b1 is approximately between 3σ and
4σ at scales of 3–7°. There are reports of mildly unusual behaviour of the Euler
characteristic at 3.66° in the literature, computed from independent measurements
of the CMB temperature fluctuations by Planck’s predecessor, the Wilkinson Microwave
Anisotropy Probe (WMAP) satellite. The mildly anomalous behaviour of the Euler
characteristic is phenomenologically related to the strongly anomalous behaviour
of components and holes, or the zeroth and first Betti numbers, respectively.
Further, since these topological descriptors show consistent anomalous behaviour
over independent measurements of Planck and WMAP, instrumental and systematic
errors may be an unlikely source. These are also the scales at which the observed
maps exhibit low variance compared to the simulations, and approximately the range
of scales at which the power spectrum exhibits a dip with respect to the theoretical
model. Non-parametric tests show even stronger differences at almost all scales.
Crucially, Gaussian simulations based on power-spectrum matching the characteristics
of the observed dipped power spectrum are not able to resolve the anomaly. Understanding
the origin of the anomalies in the CMB, whether cosmological in nature or arising
due to late-time effects, is an extremely challenging task. Regardless, beyond
the trivial possibility that this may still be a manifestation of an extreme Gaussian
case, these observations, along with the super-horizon scales involved, may motivate
the study of primordial non-Gaussianity. Alternative scenarios worth exploring
may be models with non-trivial topology, including topological defect models."
article_number: A163
article_processing_charge: No
article_type: original
author:
- first_name: Pratyush
full_name: Pranav, Pratyush
last_name: Pranav
- first_name: Robert J.
full_name: Adler, Robert J.
last_name: Adler
- first_name: Thomas
full_name: Buchert, Thomas
last_name: Buchert
- first_name: Herbert
full_name: Edelsbrunner, Herbert
id: 3FB178DA-F248-11E8-B48F-1D18A9856A87
last_name: Edelsbrunner
orcid: 0000-0002-9823-6833
- first_name: Bernard J.T.
full_name: Jones, Bernard J.T.
last_name: Jones
- first_name: Armin
full_name: Schwartzman, Armin
last_name: Schwartzman
- first_name: Hubert
full_name: Wagner, Hubert
id: 379CA8B8-F248-11E8-B48F-1D18A9856A87
last_name: Wagner
- first_name: Rien
full_name: Van De Weygaert, Rien
last_name: Van De Weygaert
citation:
ama: Pranav P, Adler RJ, Buchert T, et al. Unexpected topology of the temperature
fluctuations in the cosmic microwave background. Astronomy and Astrophysics.
2019;627. doi:10.1051/0004-6361/201834916
apa: Pranav, P., Adler, R. J., Buchert, T., Edelsbrunner, H., Jones, B. J. T., Schwartzman,
A., … Van De Weygaert, R. (2019). Unexpected topology of the temperature fluctuations
in the cosmic microwave background. Astronomy and Astrophysics. EDP Sciences.
https://doi.org/10.1051/0004-6361/201834916
chicago: Pranav, Pratyush, Robert J. Adler, Thomas Buchert, Herbert Edelsbrunner,
Bernard J.T. Jones, Armin Schwartzman, Hubert Wagner, and Rien Van De Weygaert.
“Unexpected Topology of the Temperature Fluctuations in the Cosmic Microwave Background.”
Astronomy and Astrophysics. EDP Sciences, 2019. https://doi.org/10.1051/0004-6361/201834916.
ieee: P. Pranav et al., “Unexpected topology of the temperature fluctuations
in the cosmic microwave background,” Astronomy and Astrophysics, vol. 627.
EDP Sciences, 2019.
ista: Pranav P, Adler RJ, Buchert T, Edelsbrunner H, Jones BJT, Schwartzman A, Wagner
H, Van De Weygaert R. 2019. Unexpected topology of the temperature fluctuations
in the cosmic microwave background. Astronomy and Astrophysics. 627, A163.
mla: Pranav, Pratyush, et al. “Unexpected Topology of the Temperature Fluctuations
in the Cosmic Microwave Background.” Astronomy and Astrophysics, vol. 627,
A163, EDP Sciences, 2019, doi:10.1051/0004-6361/201834916.
short: P. Pranav, R.J. Adler, T. Buchert, H. Edelsbrunner, B.J.T. Jones, A. Schwartzman,
H. Wagner, R. Van De Weygaert, Astronomy and Astrophysics 627 (2019).
date_created: 2019-08-04T21:59:18Z
date_published: 2019-07-17T00:00:00Z
date_updated: 2023-08-29T07:01:48Z
day: '17'
ddc:
- '520'
- '530'
department:
- _id: HeEd
doi: 10.1051/0004-6361/201834916
external_id:
arxiv:
- '1812.07678'
isi:
- '000475839300003'
file:
- access_level: open_access
checksum: 83b9209ed9eefbdcefd89019c5a97805
content_type: application/pdf
creator: dernst
date_created: 2019-08-05T08:08:59Z
date_updated: 2020-07-14T12:47:39Z
file_id: '6766'
file_name: 2019_AstronomyAstrophysics_Pranav.pdf
file_size: 14420451
relation: main_file
file_date_updated: 2020-07-14T12:47:39Z
has_accepted_license: '1'
intvolume: ' 627'
isi: 1
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 265683E4-B435-11E9-9278-68D0E5697425
grant_number: M62909-18-1-2038
name: Toward Computational Information Topology
- _id: 2561EBF4-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: I02979-N35
name: Persistence and stability of geometric complexes
publication: Astronomy and Astrophysics
publication_identifier:
eissn:
- '14320746'
issn:
- '00046361'
publication_status: published
publisher: EDP Sciences
quality_controlled: '1'
scopus_import: '1'
status: public
title: Unexpected topology of the temperature fluctuations in the cosmic microwave
background
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 627
year: '2019'
...
---
_id: '6755'
abstract:
- lang: eng
text: 'Differentiated sex chromosomes are accompanied by a difference in gene dose
between X/Z-specific and autosomal genes. At the transcriptomic level, these sex-linked
genes can lead to expression imbalance, or gene dosage can be compensated by epigenetic
mechanisms and results into expression level equalization. Schistosoma mansoni
has been previously described as a ZW species (i.e., female heterogamety, in opposition
to XY male heterogametic species) with a partial dosage compensation, but underlying
mechanisms are still unexplored. Here, we combine transcriptomic (RNA-Seq) and
epigenetic data (ChIP-Seq against H3K4me3, H3K27me3,andH4K20me1histonemarks) in
free larval cercariae and intravertebrate parasitic stages. For the first time,
we describe differences in dosage compensation status in ZW females, depending
on the parasitic status: free cercariae display global dosage compensation, whereas
intravertebrate stages show a partial dosage compensation. We also highlight regional
differences of gene expression along the Z chromosome in cercariae, but not in
the intravertebrate stages. Finally, we feature a consistent permissive chromatin
landscape of the Z chromosome in both sexes and stages. We argue that dosage compensation
in schistosomes is characterized by chromatin remodeling mechanisms in the Z-specific
region.'
acknowledged_ssus:
- _id: CampIT
article_processing_charge: No
article_type: original
author:
- first_name: Marion A L
full_name: Picard, Marion A L
id: 2C921A7A-F248-11E8-B48F-1D18A9856A87
last_name: Picard
orcid: 0000-0002-8101-2518
- first_name: Beatriz
full_name: Vicoso, Beatriz
id: 49E1C5C6-F248-11E8-B48F-1D18A9856A87
last_name: Vicoso
orcid: 0000-0002-4579-8306
- first_name: David
full_name: Roquis, David
last_name: Roquis
- first_name: Ingo
full_name: Bulla, Ingo
last_name: Bulla
- first_name: Ronaldo C.
full_name: Augusto, Ronaldo C.
last_name: Augusto
- first_name: Nathalie
full_name: Arancibia, Nathalie
last_name: Arancibia
- first_name: Christoph
full_name: Grunau, Christoph
last_name: Grunau
- first_name: Jérôme
full_name: Boissier, Jérôme
last_name: Boissier
- first_name: Céline
full_name: Cosseau, Céline
last_name: Cosseau
citation:
ama: 'Picard MAL, Vicoso B, Roquis D, et al. Dosage compensation throughout the
Schistosoma mansoni lifecycle: Specific chromatin landscape of the Z chromosome.
Genome biology and evolution. 2019;11(7):1909-1922. doi:10.1093/gbe/evz133'
apa: 'Picard, M. A. L., Vicoso, B., Roquis, D., Bulla, I., Augusto, R. C., Arancibia,
N., … Cosseau, C. (2019). Dosage compensation throughout the Schistosoma mansoni
lifecycle: Specific chromatin landscape of the Z chromosome. Genome Biology
and Evolution. Oxford Academic Press. https://doi.org/10.1093/gbe/evz133'
chicago: 'Picard, Marion A L, Beatriz Vicoso, David Roquis, Ingo Bulla, Ronaldo
C. Augusto, Nathalie Arancibia, Christoph Grunau, Jérôme Boissier, and Céline
Cosseau. “Dosage Compensation throughout the Schistosoma Mansoni Lifecycle: Specific
Chromatin Landscape of the Z Chromosome.” Genome Biology and Evolution.
Oxford Academic Press, 2019. https://doi.org/10.1093/gbe/evz133.'
ieee: 'M. A. L. Picard et al., “Dosage compensation throughout the Schistosoma
mansoni lifecycle: Specific chromatin landscape of the Z chromosome,” Genome
biology and evolution, vol. 11, no. 7. Oxford Academic Press, pp. 1909–1922,
2019.'
ista: 'Picard MAL, Vicoso B, Roquis D, Bulla I, Augusto RC, Arancibia N, Grunau
C, Boissier J, Cosseau C. 2019. Dosage compensation throughout the Schistosoma
mansoni lifecycle: Specific chromatin landscape of the Z chromosome. Genome biology
and evolution. 11(7), 1909–1922.'
mla: 'Picard, Marion A. L., et al. “Dosage Compensation throughout the Schistosoma
Mansoni Lifecycle: Specific Chromatin Landscape of the Z Chromosome.” Genome
Biology and Evolution, vol. 11, no. 7, Oxford Academic Press, 2019, pp. 1909–22,
doi:10.1093/gbe/evz133.'
short: M.A.L. Picard, B. Vicoso, D. Roquis, I. Bulla, R.C. Augusto, N. Arancibia,
C. Grunau, J. Boissier, C. Cosseau, Genome Biology and Evolution 11 (2019) 1909–1922.
date_created: 2019-08-04T21:59:18Z
date_published: 2019-07-01T00:00:00Z
date_updated: 2023-08-29T06:53:58Z
day: '01'
ddc:
- '570'
department:
- _id: BeVi
doi: 10.1093/gbe/evz133
external_id:
isi:
- '000484039500018'
pmid:
- '31273378'
file:
- access_level: open_access
checksum: f9e8f6863a406dcc5a36b2be001c138c
content_type: application/pdf
creator: dernst
date_created: 2019-08-05T07:55:02Z
date_updated: 2020-07-14T12:47:39Z
file_id: '6765'
file_name: 2019_GenomeBiology_Picard.pdf
file_size: 580205
relation: main_file
file_date_updated: 2020-07-14T12:47:39Z
has_accepted_license: '1'
intvolume: ' 11'
isi: 1
issue: '7'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: 1909-1922
pmid: 1
publication: Genome biology and evolution
publication_identifier:
eissn:
- 1759-6653
publication_status: published
publisher: Oxford Academic Press
quality_controlled: '1'
scopus_import: '1'
status: public
title: 'Dosage compensation throughout the Schistosoma mansoni lifecycle: Specific
chromatin landscape of the Z chromosome'
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 11
year: '2019'
...
---
_id: '6752'
abstract:
- lang: eng
text: 'Two-player games on graphs are widely studied in formal methods, as they
model the interaction between a system and its environment. The game is played
by moving a token throughout a graph to produce an infinite path. There are several
common modes to determine how the players move the token through the graph; e.g.,
in turn-based games the players alternate turns in moving the token. We study
the bidding mode of moving the token, which, to the best of our knowledge, has
never been studied in infinite-duration games. The following bidding rule was
previously defined and called Richman bidding. Both players have separate budgets,
which sum up to 1. In each turn, a bidding takes place: Both players submit bids
simultaneously, where a bid is legal if it does not exceed the available budget,
and the higher bidder pays his bid to the other player and moves the token. The
central question studied in bidding games is a necessary and sufficient initial
budget for winning the game: a threshold budget in a vertex is a value t ∈ [0,
1] such that if Player 1’s budget exceeds t, he can win the game; and if Player
2’s budget exceeds 1 − t, he can win the game. Threshold budgets were previously
shown to exist in every vertex of a reachability game, which have an interesting
connection with random-turn games—a sub-class of simple stochastic games in which
the player who moves is chosen randomly. We show the existence of threshold budgets
for a qualitative class of infinite-duration games, namely parity games, and a
quantitative class, namely mean-payoff games. The key component of the proof is
a quantitative solution to strongly connected mean-payoff bidding games in which
we extend the connection with random-turn games to these games, and construct
explicit optimal strategies for both players.'
article_number: '31'
article_processing_charge: No
author:
- first_name: Guy
full_name: Avni, Guy
id: 463C8BC2-F248-11E8-B48F-1D18A9856A87
last_name: Avni
orcid: 0000-0001-5588-8287
- first_name: Thomas A
full_name: Henzinger, Thomas A
id: 40876CD8-F248-11E8-B48F-1D18A9856A87
last_name: Henzinger
orcid: 0000−0002−2985−7724
- first_name: Ventsislav K
full_name: Chonev, Ventsislav K
id: 36CBE2E6-F248-11E8-B48F-1D18A9856A87
last_name: Chonev
citation:
ama: Avni G, Henzinger TA, Chonev VK. Infinite-duration bidding games. Journal
of the ACM. 2019;66(4). doi:10.1145/3340295
apa: Avni, G., Henzinger, T. A., & Chonev, V. K. (2019). Infinite-duration bidding
games. Journal of the ACM. ACM. https://doi.org/10.1145/3340295
chicago: Avni, Guy, Thomas A Henzinger, and Ventsislav K Chonev. “Infinite-Duration
Bidding Games.” Journal of the ACM. ACM, 2019. https://doi.org/10.1145/3340295.
ieee: G. Avni, T. A. Henzinger, and V. K. Chonev, “Infinite-duration bidding games,”
Journal of the ACM, vol. 66, no. 4. ACM, 2019.
ista: Avni G, Henzinger TA, Chonev VK. 2019. Infinite-duration bidding games. Journal
of the ACM. 66(4), 31.
mla: Avni, Guy, et al. “Infinite-Duration Bidding Games.” Journal of the ACM,
vol. 66, no. 4, 31, ACM, 2019, doi:10.1145/3340295.
short: G. Avni, T.A. Henzinger, V.K. Chonev, Journal of the ACM 66 (2019).
date_created: 2019-08-04T21:59:16Z
date_published: 2019-07-16T00:00:00Z
date_updated: 2023-08-29T07:02:13Z
day: '16'
department:
- _id: ToHe
doi: 10.1145/3340295
external_id:
arxiv:
- '1705.01433'
isi:
- '000487714900008'
intvolume: ' 66'
isi: 1
issue: '4'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1705.01433
month: '07'
oa: 1
oa_version: Preprint
project:
- _id: 25F42A32-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: Z211
name: The Wittgenstein Prize
- _id: 25F2ACDE-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S11402-N23
name: Rigorous Systems Engineering
- _id: 264B3912-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: M02369
name: Formal Methods meets Algorithmic Game Theory
publication: Journal of the ACM
publication_identifier:
eissn:
- 1557735X
issn:
- '00045411'
publication_status: published
publisher: ACM
quality_controlled: '1'
related_material:
record:
- id: '950'
relation: earlier_version
status: public
scopus_import: '1'
status: public
title: Infinite-duration bidding games
type: journal_article
user_id: 4359f0d1-fa6c-11eb-b949-802e58b17ae8
volume: 66
year: '2019'
...