[{"article_number":"16032","citation":{"ama":"Simonnet J, Nassar M, Stella F, et al. Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum. Nature Communications. 2017;8. doi:10.1038/ncomms16032","apa":"Simonnet, J., Nassar, M., Stella, F., Cohen, I., Mathon, B., Boccara, C. N., … Fricker, D. (2017). Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/ncomms16032","ieee":"J. Simonnet et al., “Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum,” Nature Communications, vol. 8. Nature Publishing Group, 2017.","short":"J. Simonnet, M. Nassar, F. Stella, I. Cohen, B. Mathon, C.N. Boccara, R. Miles, D. Fricker, Nature Communications 8 (2017).","mla":"Simonnet, Jean, et al. “Activity Dependent Feedback Inhibition May Maintain Head Direction Signals in Mouse Presubiculum.” Nature Communications, vol. 8, 16032, Nature Publishing Group, 2017, doi:10.1038/ncomms16032.","ista":"Simonnet J, Nassar M, Stella F, Cohen I, Mathon B, Boccara CN, Miles R, Fricker D. 2017. Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum. Nature Communications. 8, 16032.","chicago":"Simonnet, Jean, Mérie Nassar, Federico Stella, Ivan Cohen, Bertrand Mathon, Charlotte N. Boccara, Richard Miles, and Desdemona Fricker. “Activity Dependent Feedback Inhibition May Maintain Head Direction Signals in Mouse Presubiculum.” Nature Communications. Nature Publishing Group, 2017. https://doi.org/10.1038/ncomms16032."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"first_name":"Jean","last_name":"Simonnet","full_name":"Simonnet, Jean"},{"first_name":"Mérie","full_name":"Nassar, Mérie","last_name":"Nassar"},{"last_name":"Stella","full_name":"Stella, Federico","orcid":"0000-0001-9439-3148","first_name":"Federico","id":"39AF1E74-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Ivan","full_name":"Cohen, Ivan","last_name":"Cohen"},{"last_name":"Mathon","full_name":"Mathon, Bertrand","first_name":"Bertrand"},{"id":"3FC06552-F248-11E8-B48F-1D18A9856A87","first_name":"Charlotte","last_name":"Boccara","orcid":"0000-0001-7237-5109","full_name":"Boccara, Charlotte"},{"last_name":"Miles","full_name":"Miles, Richard","first_name":"Richard"},{"last_name":"Fricker","full_name":"Fricker, Desdemona","first_name":"Desdemona"}],"publist_id":"7305","title":"Activity dependent feedback inhibition may maintain head direction signals in mouse presubiculum","oa":1,"publisher":"Nature Publishing Group","quality_controlled":"1","year":"2017","has_accepted_license":"1","publication":"Nature Communications","day":"01","date_created":"2018-12-11T11:46:54Z","date_published":"2017-07-01T00:00:00Z","doi":"10.1038/ncomms16032","_id":"514","tmp":{"legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","image":"/images/cc_by.png","name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","short":"CC BY (4.0)"},"type":"journal_article","pubrep_id":"937","status":"public","date_updated":"2021-01-12T08:01:16Z","ddc":["571"],"department":[{"_id":"JoCs"}],"file_date_updated":"2020-07-14T12:46:36Z","abstract":[{"lang":"eng","text":"Orientation in space is represented in specialized brain circuits. Persistent head direction signals are transmitted from anterior thalamus to the presubiculum, but the identity of the presubicular target neurons, their connectivity and function in local microcircuits are unknown. Here, we examine how thalamic afferents recruit presubicular principal neurons and Martinotti interneurons, and the ensuing synaptic interactions between these cells. Pyramidal neuron activation of Martinotti cells in superficial layers is strongly facilitating such that high-frequency head directional stimulation efficiently unmutes synaptic excitation. Martinotti-cell feedback plays a dual role: precisely timed spikes may not inhibit the firing of in-tune head direction cells, while exerting lateral inhibition. Autonomous attractor dynamics emerge from a modelled network implementing wiring motifs and timing sensitive synaptic interactions in the pyramidal - Martinotti-cell feedback loop. This inhibitory microcircuit is therefore tuned to refine and maintain head direction information in the presubiculum."}],"oa_version":"Published Version","scopus_import":1,"intvolume":" 8","month":"07","publication_status":"published","publication_identifier":{"issn":["20411723"]},"language":[{"iso":"eng"}],"file":[{"checksum":"76d8a2b72a58e56adb410ec37dfa7eee","file_id":"5083","content_type":"application/pdf","access_level":"open_access","relation":"main_file","date_created":"2018-12-12T10:14:31Z","file_name":"IST-2018-937-v1+1_2017_Stella_Activity_dependent.pdf","date_updated":"2020-07-14T12:46:36Z","file_size":2948357,"creator":"system"}],"license":"https://creativecommons.org/licenses/by/4.0/","volume":8},{"language":[{"iso":"eng"}],"file":[{"creator":"lsazanov","file_size":4118385,"date_updated":"2020-07-14T12:46:36Z","file_name":"29893_2_merged_1501257589_red.pdf","date_created":"2019-11-07T12:51:07Z","relation":"main_file","access_level":"open_access","content_type":"application/pdf","checksum":"9bc7e8c41b43636dd7566289e511f096","file_id":"6993"}],"publication_status":"published","publication_identifier":{"issn":["15459993"]},"ec_funded":1,"issue":"10","volume":24,"oa_version":"Submitted Version","abstract":[{"lang":"eng","text":"The oxidative phosphorylation electron transport chain (OXPHOS-ETC) of the inner mitochondrial membrane is composed of five large protein complexes, named CI-CV. These complexes convert energy from the food we eat into ATP, a small molecule used to power a multitude of essential reactions throughout the cell. OXPHOS-ETC complexes are organized into supercomplexes (SCs) of defined stoichiometry: CI forms a supercomplex with CIII2 and CIV (SC I+III2+IV, known as the respirasome), as well as with CIII2 alone (SC I+III2). CIII2 forms a supercomplex with CIV (SC III2+IV) and CV forms dimers (CV2). Recent cryo-EM studies have revealed the structures of SC I+III2+IV and SC I+III2. Furthermore, recent work has shed light on the assembly and function of the SCs. Here we review and compare these recent studies and discuss how they have advanced our understanding of mitochondrial electron transport."}],"intvolume":" 24","month":"10","scopus_import":1,"ddc":["572"],"date_updated":"2021-01-12T08:01:17Z","department":[{"_id":"LeSa"}],"file_date_updated":"2020-07-14T12:46:36Z","_id":"515","status":"public","type":"journal_article","article_type":"original","publication":"Nature Structural and Molecular Biology","day":"05","year":"2017","has_accepted_license":"1","date_created":"2018-12-11T11:46:54Z","doi":"10.1038/nsmb.3460","date_published":"2017-10-05T00:00:00Z","page":"800 - 808","oa":1,"publisher":"Nature Publishing Group","quality_controlled":"1","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","citation":{"ista":"Letts JA, Sazanov LA. 2017. Clarifying the supercomplex: The higher-order organization of the mitochondrial electron transport chain. Nature Structural and Molecular Biology. 24(10), 800–808.","chicago":"Letts, James A, and Leonid A Sazanov. “Clarifying the Supercomplex: The Higher-Order Organization of the Mitochondrial Electron Transport Chain.” Nature Structural and Molecular Biology. Nature Publishing Group, 2017. https://doi.org/10.1038/nsmb.3460.","apa":"Letts, J. A., & Sazanov, L. A. (2017). Clarifying the supercomplex: The higher-order organization of the mitochondrial electron transport chain. Nature Structural and Molecular Biology. Nature Publishing Group. https://doi.org/10.1038/nsmb.3460","ama":"Letts JA, Sazanov LA. Clarifying the supercomplex: The higher-order organization of the mitochondrial electron transport chain. Nature Structural and Molecular Biology. 2017;24(10):800-808. doi:10.1038/nsmb.3460","ieee":"J. A. Letts and L. A. Sazanov, “Clarifying the supercomplex: The higher-order organization of the mitochondrial electron transport chain,” Nature Structural and Molecular Biology, vol. 24, no. 10. Nature Publishing Group, pp. 800–808, 2017.","short":"J.A. Letts, L.A. Sazanov, Nature Structural and Molecular Biology 24 (2017) 800–808.","mla":"Letts, James A., and Leonid A. Sazanov. “Clarifying the Supercomplex: The Higher-Order Organization of the Mitochondrial Electron Transport Chain.” Nature Structural and Molecular Biology, vol. 24, no. 10, Nature Publishing Group, 2017, pp. 800–08, doi:10.1038/nsmb.3460."},"title":"Clarifying the supercomplex: The higher-order organization of the mitochondrial electron transport chain","author":[{"first_name":"James A","id":"322DA418-F248-11E8-B48F-1D18A9856A87","last_name":"Letts","orcid":"0000-0002-9864-3586","full_name":"Letts, James A"},{"id":"338D39FE-F248-11E8-B48F-1D18A9856A87","first_name":"Leonid A","last_name":"Sazanov","orcid":"0000-0002-0977-7989","full_name":"Sazanov, Leonid A"}],"publist_id":"7304","project":[{"name":"Atomic-Resolution Structures of Mitochondrial Respiratory Chain Supercomplexes (H2020)","grant_number":"701309","_id":"2590DB08-B435-11E9-9278-68D0E5697425","call_identifier":"H2020"}]},{"year":"2017","publication_status":"published","publication":"Physical Review Fluids","language":[{"iso":"eng"}],"day":"01","date_created":"2018-12-11T11:46:54Z","date_published":"2017-04-01T00:00:00Z","issue":"4","volume":2,"doi":"10.1103/PhysRevFluids.2.043904","abstract":[{"text":"We present an experimental setup that creates a shear flow with zero mean advection velocity achieved by counterbalancing the nonzero streamwise pressure gradient by moving boundaries, which generates plane Couette-Poiseuille flow. We obtain experimental results in the transitional regime for this flow. Using flow visualization, we characterize the subcritical transition to turbulence in Couette-Poiseuille flow and show the existence of turbulent spots generated by a permanent perturbation. Due to the zero mean advection velocity of the base profile, these turbulent structures are nearly stationary. We distinguish two regions of the turbulent spot: the active turbulent core, which is characterized by waviness of the streaks similar to traveling waves, and the surrounding region, which includes in addition the weak undisturbed streaks and oblique waves at the laminar-turbulent interface. We also study the dependence of the size of these two regions on Reynolds number. Finally, we show that the traveling waves move in the downstream (Poiseuille) direction.","lang":"eng"}],"oa_version":"Preprint","oa":1,"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1704.02619"}],"quality_controlled":"1","scopus_import":1,"publisher":"American Physical Society","intvolume":" 2","month":"04","date_updated":"2021-01-12T08:01:16Z","citation":{"ista":"Klotz L, Lemoult GM, Frontczak I, Tuckerman L, Wesfreid J. 2017. Couette-Poiseuille flow experiment with zero mean advection velocity: Subcritical transition to turbulence. Physical Review Fluids. 2(4), 043904.","chicago":"Klotz, Lukasz, Grégoire M Lemoult, Idalia Frontczak, Laurette Tuckerman, and José Wesfreid. “Couette-Poiseuille Flow Experiment with Zero Mean Advection Velocity: Subcritical Transition to Turbulence.” Physical Review Fluids. American Physical Society, 2017. https://doi.org/10.1103/PhysRevFluids.2.043904.","short":"L. Klotz, G.M. Lemoult, I. Frontczak, L. Tuckerman, J. Wesfreid, Physical Review Fluids 2 (2017).","ieee":"L. Klotz, G. M. Lemoult, I. Frontczak, L. Tuckerman, and J. Wesfreid, “Couette-Poiseuille flow experiment with zero mean advection velocity: Subcritical transition to turbulence,” Physical Review Fluids, vol. 2, no. 4. American Physical Society, 2017.","ama":"Klotz L, Lemoult GM, Frontczak I, Tuckerman L, Wesfreid J. Couette-Poiseuille flow experiment with zero mean advection velocity: Subcritical transition to turbulence. Physical Review Fluids. 2017;2(4). doi:10.1103/PhysRevFluids.2.043904","apa":"Klotz, L., Lemoult, G. M., Frontczak, I., Tuckerman, L., & Wesfreid, J. (2017). Couette-Poiseuille flow experiment with zero mean advection velocity: Subcritical transition to turbulence. Physical Review Fluids. American Physical Society. https://doi.org/10.1103/PhysRevFluids.2.043904","mla":"Klotz, Lukasz, et al. “Couette-Poiseuille Flow Experiment with Zero Mean Advection Velocity: Subcritical Transition to Turbulence.” Physical Review Fluids, vol. 2, no. 4, 043904, American Physical Society, 2017, doi:10.1103/PhysRevFluids.2.043904."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","author":[{"id":"2C9AF1C2-F248-11E8-B48F-1D18A9856A87","first_name":"Lukasz","orcid":"0000-0003-1740-7635","full_name":"Klotz, Lukasz","last_name":"Klotz"},{"first_name":"Grégoire M","id":"4787FE80-F248-11E8-B48F-1D18A9856A87","last_name":"Lemoult","full_name":"Lemoult, Grégoire M"},{"first_name":"Idalia","full_name":"Frontczak, Idalia","last_name":"Frontczak"},{"last_name":"Tuckerman","full_name":"Tuckerman, Laurette","first_name":"Laurette"},{"full_name":"Wesfreid, José","last_name":"Wesfreid","first_name":"José"}],"publist_id":"7306","department":[{"_id":"BjHo"}],"title":"Couette-Poiseuille flow experiment with zero mean advection velocity: Subcritical transition to turbulence","_id":"513","article_number":"043904","type":"journal_article","status":"public"},{"scopus_import":1,"intvolume":" 6","month":"03","abstract":[{"text":"Cyanobacteria are mostly engineered to be sustainable cell-factories by genetic manipulations alone. Here, by modulating the concentration of allosteric effectors, we focus on increasing product formation without further burdening the cells with increased expression of enzymes. Resorting to a novel 96-well microplate cultivation system for cyanobacteria, and using lactate-producing strains of Synechocystis PCC6803 expressing different l-lactate dehydrogenases (LDH), we titrated the effect of 2,5-anhydro-mannitol supplementation. The latter acts in cells as a nonmetabolizable analogue of fructose 1,6-bisphosphate, a known allosteric regulator of one of the tested LDHs. In this strain (SAA023), we achieved over 2-fold increase of lactate productivity. Furthermore, we observed that as carbon is increasingly deviated during growth toward product formation, there is an increased fixation rate in the population of spontaneous mutants harboring an impaired production pathway. This is a challenge in the development of green cell factories, which may be countered by the incorporation in biotechnological processes of strategies such as the one pioneered here.","lang":"eng"}],"oa_version":"None","pmid":1,"issue":"3","volume":6,"publication_status":"published","publication_identifier":{"issn":["21615063"]},"language":[{"iso":"eng"}],"type":"journal_article","article_type":"letter_note","status":"public","_id":"520","department":[{"_id":"ToBo"}],"date_updated":"2021-01-12T08:01:21Z","publisher":"American Chemical Society","quality_controlled":"1","page":"395 - 401","date_created":"2018-12-11T11:46:56Z","doi":"10.1021/acssynbio.6b00235","date_published":"2017-03-17T00:00:00Z","year":"2017","publication":"ACS Synthetic Biology","day":"17","external_id":{"pmid":["27936615"]},"author":[{"full_name":"Du, Wei","last_name":"Du","first_name":"Wei"},{"full_name":"Angermayr, Andreas","orcid":"0000-0001-8619-2223","last_name":"Angermayr","first_name":"Andreas","id":"4677C796-F248-11E8-B48F-1D18A9856A87"},{"full_name":"Jongbloets, Joeri","last_name":"Jongbloets","first_name":"Joeri"},{"last_name":"Molenaar","full_name":"Molenaar, Douwe","first_name":"Douwe"},{"first_name":"Herwig","full_name":"Bachmann, Herwig","last_name":"Bachmann"},{"last_name":"Hellingwerf","full_name":"Hellingwerf, Klaas","first_name":"Klaas"},{"full_name":"Branco Dos Santos, Filipe","last_name":"Branco Dos Santos","first_name":"Filipe"}],"publist_id":"7298","title":"Nonhierarchical flux regulation exposes the fitness burden associated with lactate production in Synechocystis sp. PCC6803","citation":{"chicago":"Du, Wei, Andreas Angermayr, Joeri Jongbloets, Douwe Molenaar, Herwig Bachmann, Klaas Hellingwerf, and Filipe Branco Dos Santos. “Nonhierarchical Flux Regulation Exposes the Fitness Burden Associated with Lactate Production in Synechocystis Sp. PCC6803.” ACS Synthetic Biology. American Chemical Society, 2017. https://doi.org/10.1021/acssynbio.6b00235.","ista":"Du W, Angermayr A, Jongbloets J, Molenaar D, Bachmann H, Hellingwerf K, Branco Dos Santos F. 2017. Nonhierarchical flux regulation exposes the fitness burden associated with lactate production in Synechocystis sp. PCC6803. ACS Synthetic Biology. 6(3), 395–401.","mla":"Du, Wei, et al. “Nonhierarchical Flux Regulation Exposes the Fitness Burden Associated with Lactate Production in Synechocystis Sp. PCC6803.” ACS Synthetic Biology, vol. 6, no. 3, American Chemical Society, 2017, pp. 395–401, doi:10.1021/acssynbio.6b00235.","ieee":"W. Du et al., “Nonhierarchical flux regulation exposes the fitness burden associated with lactate production in Synechocystis sp. PCC6803,” ACS Synthetic Biology, vol. 6, no. 3. American Chemical Society, pp. 395–401, 2017.","short":"W. Du, A. Angermayr, J. Jongbloets, D. Molenaar, H. Bachmann, K. Hellingwerf, F. Branco Dos Santos, ACS Synthetic Biology 6 (2017) 395–401.","apa":"Du, W., Angermayr, A., Jongbloets, J., Molenaar, D., Bachmann, H., Hellingwerf, K., & Branco Dos Santos, F. (2017). Nonhierarchical flux regulation exposes the fitness burden associated with lactate production in Synechocystis sp. PCC6803. ACS Synthetic Biology. American Chemical Society. https://doi.org/10.1021/acssynbio.6b00235","ama":"Du W, Angermayr A, Jongbloets J, et al. Nonhierarchical flux regulation exposes the fitness burden associated with lactate production in Synechocystis sp. PCC6803. ACS Synthetic Biology. 2017;6(3):395-401. doi:10.1021/acssynbio.6b00235"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"publication_status":"published","year":"2017","publication_identifier":{"issn":["01668641"]},"publication":"Topology and its Applications","language":[{"iso":"eng"}],"day":"01","page":"45 - 57","date_created":"2018-12-11T11:46:56Z","volume":215,"date_published":"2017-01-01T00:00:00Z","doi":"10.1016/j.topol.2016.10.005","abstract":[{"text":"Let X and Y be proper metric spaces. We show that a coarsely n-to-1 map f:X→Y induces an n-to-1 map of Higson coronas. This viewpoint turns out to be successful in showing that the classical dimension raising theorems hold in large scale; that is, if f:X→Y is a coarsely n-to-1 map between proper metric spaces X and Y then asdim(Y)≤asdim(X)+n−1. Furthermore we introduce coarsely open coarsely n-to-1 maps, which include the natural quotient maps via a finite group action, and prove that they preserve the asymptotic dimension.","lang":"eng"}],"oa_version":"Submitted Version","oa":1,"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1608.03954v1"}],"publisher":"Elsevier","quality_controlled":"1","intvolume":" 215","month":"01","citation":{"chicago":"Austin, Kyle, and Ziga Virk. “Higson Compactification and Dimension Raising.” Topology and Its Applications. Elsevier, 2017. https://doi.org/10.1016/j.topol.2016.10.005.","ista":"Austin K, Virk Z. 2017. Higson compactification and dimension raising. Topology and its Applications. 215, 45–57.","mla":"Austin, Kyle, and Ziga Virk. “Higson Compactification and Dimension Raising.” Topology and Its Applications, vol. 215, Elsevier, 2017, pp. 45–57, doi:10.1016/j.topol.2016.10.005.","apa":"Austin, K., & Virk, Z. (2017). Higson compactification and dimension raising. Topology and Its Applications. Elsevier. https://doi.org/10.1016/j.topol.2016.10.005","ama":"Austin K, Virk Z. Higson compactification and dimension raising. Topology and its Applications. 2017;215:45-57. doi:10.1016/j.topol.2016.10.005","short":"K. Austin, Z. Virk, Topology and Its Applications 215 (2017) 45–57.","ieee":"K. Austin and Z. Virk, “Higson compactification and dimension raising,” Topology and its Applications, vol. 215. Elsevier, pp. 45–57, 2017."},"date_updated":"2021-01-12T08:01:21Z","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","publist_id":"7299","author":[{"first_name":"Kyle","full_name":"Austin, Kyle","last_name":"Austin"},{"last_name":"Virk","full_name":"Virk, Ziga","first_name":"Ziga","id":"2E36B656-F248-11E8-B48F-1D18A9856A87"}],"department":[{"_id":"HeEd"}],"title":"Higson compactification and dimension raising","_id":"521","type":"journal_article","status":"public"}]