[{"publication_identifier":{"issn":["00219606"]},"month":"06","doi":"10.1063/1.4983703","language":[{"iso":"eng"}],"external_id":{"isi":["000405089400047"]},"main_file_link":[{"open_access":"1","url":"https://arxiv.org/abs/1704.03684"}],"oa":1,"quality_controlled":"1","isi":1,"publist_id":"6403","article_number":"013946","author":[{"last_name":"Shepperson","first_name":"Benjamin","full_name":"Shepperson, Benjamin"},{"first_name":"Adam","last_name":"Chatterley","full_name":"Chatterley, Adam"},{"last_name":"Søndergaard","first_name":"Anders","full_name":"Søndergaard, Anders"},{"full_name":"Christiansen, Lars","last_name":"Christiansen","first_name":"Lars"},{"last_name":"Lemeshko","first_name":"Mikhail","orcid":"0000-0002-6990-7802","id":"37CB05FA-F248-11E8-B48F-1D18A9856A87","full_name":"Lemeshko, Mikhail"},{"last_name":"Stapelfeldt","first_name":"Henrik","full_name":"Stapelfeldt, Henrik"}],"volume":147,"date_created":"2018-12-11T11:49:36Z","date_updated":"2024-02-28T13:02:26Z","year":"2017","publisher":"AIP Publishing","department":[{"_id":"MiLe"}],"publication_status":"published","article_processing_charge":"No","day":"01","scopus_import":"1","date_published":"2017-06-01T00:00:00Z","citation":{"ama":"Shepperson B, Chatterley A, Søndergaard A, Christiansen L, Lemeshko M, Stapelfeldt H. Strongly aligned molecules inside helium droplets in the near-adiabatic regime. The Journal of Chemical Physics. 2017;147(1). doi:10.1063/1.4983703","ista":"Shepperson B, Chatterley A, Søndergaard A, Christiansen L, Lemeshko M, Stapelfeldt H. 2017. Strongly aligned molecules inside helium droplets in the near-adiabatic regime. The Journal of Chemical Physics. 147(1), 013946.","ieee":"B. Shepperson, A. Chatterley, A. Søndergaard, L. Christiansen, M. Lemeshko, and H. Stapelfeldt, “Strongly aligned molecules inside helium droplets in the near-adiabatic regime,” The Journal of Chemical Physics, vol. 147, no. 1. AIP Publishing, 2017.","apa":"Shepperson, B., Chatterley, A., Søndergaard, A., Christiansen, L., Lemeshko, M., & Stapelfeldt, H. (2017). Strongly aligned molecules inside helium droplets in the near-adiabatic regime. The Journal of Chemical Physics. AIP Publishing. https://doi.org/10.1063/1.4983703","mla":"Shepperson, Benjamin, et al. “Strongly Aligned Molecules inside Helium Droplets in the Near-Adiabatic Regime.” The Journal of Chemical Physics, vol. 147, no. 1, 013946, AIP Publishing, 2017, doi:10.1063/1.4983703.","short":"B. Shepperson, A. Chatterley, A. Søndergaard, L. Christiansen, M. Lemeshko, H. Stapelfeldt, The Journal of Chemical Physics 147 (2017).","chicago":"Shepperson, Benjamin, Adam Chatterley, Anders Søndergaard, Lars Christiansen, Mikhail Lemeshko, and Henrik Stapelfeldt. “Strongly Aligned Molecules inside Helium Droplets in the Near-Adiabatic Regime.” The Journal of Chemical Physics. AIP Publishing, 2017. https://doi.org/10.1063/1.4983703."},"publication":"The Journal of Chemical Physics","issue":"1","abstract":[{"text":"Iodine (I 2 ) molecules embedded in He nanodroplets are aligned by a 160 ps long laser pulse. The highest degree of alignment, occurring at the peak of the pulse and quantified by ⟨cos 2 θ 2D ⟩ , is measured as a function of the laser intensity. The results are well described by ⟨cos 2 θ 2D ⟩ calculated for a gas of isolated molecules each with an effective rotational constant of 0.6 times the gas-phase value, and at a temperature of 0.4 K. Theoretical analysis using the angulon quasiparticle to describe rotating molecules in superfluid helium rationalizes why the alignment mechanism is similar to that of isolated molecules with an effective rotational constant. A major advantage of molecules in He droplets is that their 0.4 K temperature leads to stronger alignment than what can generally be achieved for gas phase molecules -- here demonstrated by a direct comparison of the droplet results to measurements on a ∼ 1 K supersonic beam of isolated molecules. This point is further illustrated for more complex system by measurements on 1,4-diiodobenzene and 1,4-dibromobenzene. For all three molecular species studied the highest values of ⟨cos 2 θ 2D ⟩ achieved in He droplets exceed 0.96. ","lang":"eng"}],"type":"journal_article","oa_version":"Submitted Version","_id":"996","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":" 147","title":"Strongly aligned molecules inside helium droplets in the near-adiabatic regime","status":"public"},{"article_processing_charge":"No","day":"01","scopus_import":"1","date_published":"2017-08-01T00:00:00Z","citation":{"short":"A. Deuchert, Journal of Mathematical Physics 58 (2017).","mla":"Deuchert, Andreas. “A Lower Bound for the BCS Functional with Boundary Conditions at Infinity.” Journal of Mathematical Physics, vol. 58, no. 8, 081901, AIP Publishing, 2017, doi:10.1063/1.4996580.","chicago":"Deuchert, Andreas. “A Lower Bound for the BCS Functional with Boundary Conditions at Infinity.” Journal of Mathematical Physics. AIP Publishing, 2017. https://doi.org/10.1063/1.4996580.","ama":"Deuchert A. A lower bound for the BCS functional with boundary conditions at infinity. Journal of Mathematical Physics. 2017;58(8). doi:10.1063/1.4996580","ieee":"A. Deuchert, “A lower bound for the BCS functional with boundary conditions at infinity,” Journal of Mathematical Physics, vol. 58, no. 8. AIP Publishing, 2017.","apa":"Deuchert, A. (2017). A lower bound for the BCS functional with boundary conditions at infinity. Journal of Mathematical Physics. AIP Publishing. https://doi.org/10.1063/1.4996580","ista":"Deuchert A. 2017. A lower bound for the BCS functional with boundary conditions at infinity. Journal of Mathematical Physics. 58(8), 081901."},"publication":" Journal of Mathematical Physics","issue":"8","abstract":[{"lang":"eng","text":"We consider a many-body system of fermionic atoms interacting via a local pair potential and subject to an external potential within the framework of Bardeen-Cooper-Schrieffer (BCS) theory. We measure the free energy of the whole sample with respect to the free energy of a reference state which allows us to define a BCS functional with boundary conditions at infinity. Our main result is a lower bound for this energy functional in terms of expressions that typically appear in Ginzburg-Landau functionals.\r\n"}],"type":"journal_article","oa_version":"Submitted Version","_id":"912","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","intvolume":" 58","status":"public","title":"A lower bound for the BCS functional with boundary conditions at infinity","publication_identifier":{"issn":["00222488"]},"month":"08","doi":"10.1063/1.4996580","language":[{"iso":"eng"}],"main_file_link":[{"url":"https://arxiv.org/abs/1703.04616","open_access":"1"}],"oa":1,"external_id":{"isi":["000409197200015"]},"project":[{"name":"Analysis of quantum many-body systems","call_identifier":"H2020","_id":"25C6DC12-B435-11E9-9278-68D0E5697425","grant_number":"694227"}],"isi":1,"quality_controlled":"1","ec_funded":1,"publist_id":"6531","article_number":"081901","author":[{"orcid":"0000-0003-3146-6746","id":"4DA65CD0-F248-11E8-B48F-1D18A9856A87","last_name":"Deuchert","first_name":"Andreas","full_name":"Deuchert, Andreas"}],"volume":58,"date_updated":"2024-02-28T13:07:56Z","date_created":"2018-12-11T11:49:10Z","year":"2017","publisher":"AIP Publishing","department":[{"_id":"RoSe"}],"publication_status":"published"},{"publication":"PLoS One","citation":{"chicago":"Lukacisin, Martin, Matthieu Landon, and Rishi Jajoo. “Sequence-Specific Thermodynamic Properties of Nucleic Acids Influence Both Transcriptional Pausing and Backtracking in Yeast.” PLoS One. Public Library of Science, 2017. https://doi.org/10.1371/journal.pone.0174066.","mla":"Lukacisin, Martin, et al. “Sequence-Specific Thermodynamic Properties of Nucleic Acids Influence Both Transcriptional Pausing and Backtracking in Yeast.” PLoS One, vol. 12, no. 3, e0174066, Public Library of Science, 2017, doi:10.1371/journal.pone.0174066.","short":"M. Lukacisin, M. Landon, R. Jajoo, PLoS One 12 (2017).","ista":"Lukacisin M, Landon M, Jajoo R. 2017. Sequence-specific thermodynamic properties of nucleic acids influence both transcriptional pausing and backtracking in yeast. PLoS One. 12(3), e0174066.","ieee":"M. Lukacisin, M. Landon, and R. Jajoo, “Sequence-specific thermodynamic properties of nucleic acids influence both transcriptional pausing and backtracking in yeast,” PLoS One, vol. 12, no. 3. Public Library of Science, 2017.","apa":"Lukacisin, M., Landon, M., & Jajoo, R. (2017). Sequence-specific thermodynamic properties of nucleic acids influence both transcriptional pausing and backtracking in yeast. PLoS One. Public Library of Science. https://doi.org/10.1371/journal.pone.0174066","ama":"Lukacisin M, Landon M, Jajoo R. Sequence-specific thermodynamic properties of nucleic acids influence both transcriptional pausing and backtracking in yeast. PLoS One. 2017;12(3). doi:10.1371/journal.pone.0174066"},"date_published":"2017-03-16T00:00:00Z","scopus_import":"1","day":"16","article_processing_charge":"Yes","has_accepted_license":"1","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","_id":"1029","status":"public","title":"Sequence-specific thermodynamic properties of nucleic acids influence both transcriptional pausing and backtracking in yeast","ddc":["570"],"intvolume":" 12","pubrep_id":"800","file":[{"file_name":"IST-2017-800-v1+1_journal.pone.0174066.pdf","access_level":"open_access","creator":"system","content_type":"application/pdf","file_size":3429381,"file_id":"4772","relation":"main_file","date_updated":"2018-12-12T10:09:47Z","date_created":"2018-12-12T10:09:47Z"}],"oa_version":"Published Version","type":"journal_article","abstract":[{"lang":"eng","text":"RNA Polymerase II pauses and backtracks during transcription, with many consequences for gene expression and cellular physiology. Here, we show that the energy required to melt double-stranded nucleic acids in the transcription bubble predicts pausing in Saccharomyces cerevisiae far more accurately than nucleosome roadblocks do. In addition, the same energy difference also determines when the RNA polymerase backtracks instead of continuing to move forward. This data-driven model corroborates—in a genome wide and quantitative manner—previous evidence that sequence-dependent thermodynamic features of nucleic acids influence both transcriptional pausing and backtracking."}],"issue":"3","external_id":{"isi":["000396318300121"]},"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"oa":1,"quality_controlled":"1","isi":1,"doi":"10.1371/journal.pone.0174066","language":[{"iso":"eng"}],"month":"03","publication_identifier":{"issn":["19326203"]},"year":"2017","publication_status":"published","publisher":"Public Library of Science","department":[{"_id":"ToBo"}],"author":[{"first_name":"Martin","last_name":"Lukacisin","id":"298FFE8C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-6549-4177","full_name":"Lukacisin, Martin"},{"full_name":"Landon, Matthieu","last_name":"Landon","first_name":"Matthieu"},{"first_name":"Rishi","last_name":"Jajoo","full_name":"Jajoo, Rishi"}],"related_material":{"record":[{"id":"5556","relation":"popular_science","status":"public"},{"id":"6392","relation":"dissertation_contains","status":"public"}]},"date_created":"2018-12-11T11:49:46Z","date_updated":"2024-03-28T23:30:04Z","volume":12,"article_number":"e0174066","file_date_updated":"2018-12-12T10:09:47Z","publist_id":"6361"},{"type":"journal_article","abstract":[{"lang":"eng","text":"Immune cells communicate using cytokine signals, but the quantitative rules of this communication aren't clear. In this issue of Immunity, Oyler-Yaniv et al. (2017) suggest that the distribution of a cytokine within a lymphatic organ is primarily governed by the local density of cells consuming it."}],"publist_id":"7065","issue":"4","user_id":"4435EBFC-F248-11E8-B48F-1D18A9856A87","_id":"664","year":"2017","status":"public","publication_status":"published","title":"The dynamic cytokine niche","publisher":"Cell Press","intvolume":" 46","department":[{"_id":"MiSi"}],"author":[{"full_name":"Assen, Frank P","orcid":"0000-0003-3470-6119","id":"3A8E7F24-F248-11E8-B48F-1D18A9856A87","last_name":"Assen","first_name":"Frank P"},{"last_name":"Sixt","first_name":"Michael K","orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","full_name":"Sixt, Michael K"}],"related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"6947"}]},"date_created":"2018-12-11T11:47:47Z","date_updated":"2024-03-28T23:30:09Z","volume":46,"oa_version":"None","scopus_import":1,"month":"04","day":"18","publication_identifier":{"issn":["10747613"]},"publication":"Immunity","citation":{"ama":"Assen FP, Sixt MK. The dynamic cytokine niche. Immunity. 2017;46(4):519-520. doi:10.1016/j.immuni.2017.04.006","ieee":"F. P. Assen and M. K. Sixt, “The dynamic cytokine niche,” Immunity, vol. 46, no. 4. Cell Press, pp. 519–520, 2017.","apa":"Assen, F. P., & Sixt, M. K. (2017). The dynamic cytokine niche. Immunity. Cell Press. https://doi.org/10.1016/j.immuni.2017.04.006","ista":"Assen FP, Sixt MK. 2017. The dynamic cytokine niche. Immunity. 46(4), 519–520.","short":"F.P. Assen, M.K. Sixt, Immunity 46 (2017) 519–520.","mla":"Assen, Frank P., and Michael K. Sixt. “The Dynamic Cytokine Niche.” Immunity, vol. 46, no. 4, Cell Press, 2017, pp. 519–20, doi:10.1016/j.immuni.2017.04.006.","chicago":"Assen, Frank P, and Michael K Sixt. “The Dynamic Cytokine Niche.” Immunity. Cell Press, 2017. https://doi.org/10.1016/j.immuni.2017.04.006."},"quality_controlled":"1","page":"519 - 520","doi":"10.1016/j.immuni.2017.04.006","date_published":"2017-04-18T00:00:00Z","language":[{"iso":"eng"}]},{"publication_identifier":{"issn":["19326203"]},"month":"06","quality_controlled":"1","oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"language":[{"iso":"eng"}],"doi":"10.1371/journal.pone.0179377","article_number":"e0179377","publist_id":"7034","file_date_updated":"2020-07-14T12:47:40Z","publisher":"Public Library of Science","department":[{"_id":"RySh"}],"publication_status":"published","year":"2017","volume":12,"date_updated":"2024-03-28T23:30:12Z","date_created":"2018-12-11T11:47:54Z","related_material":{"record":[{"id":"51","status":"public","relation":"dissertation_contains"}]},"author":[{"full_name":"Ukai, Hikari","last_name":"Ukai","first_name":"Hikari"},{"last_name":"Kawahara","first_name":"Aiko","full_name":"Kawahara, Aiko"},{"last_name":"Hirayama","first_name":"Keiko","full_name":"Hirayama, Keiko"},{"last_name":"Case","first_name":"Matthew J","id":"44B7CA5A-F248-11E8-B48F-1D18A9856A87","full_name":"Case, Matthew J"},{"full_name":"Aino, Shotaro","last_name":"Aino","first_name":"Shotaro"},{"full_name":"Miyabe, Masahiro","first_name":"Masahiro","last_name":"Miyabe"},{"first_name":"Ken","last_name":"Wakita","full_name":"Wakita, Ken"},{"full_name":"Oogi, Ryohei","last_name":"Oogi","first_name":"Ryohei"},{"full_name":"Kasayuki, Michiyo","last_name":"Kasayuki","first_name":"Michiyo"},{"last_name":"Kawashima","first_name":"Shihomi","full_name":"Kawashima, Shihomi"},{"full_name":"Sugimoto, Shunichi","last_name":"Sugimoto","first_name":"Shunichi"},{"full_name":"Chikamatsu, Kanako","last_name":"Chikamatsu","first_name":"Kanako"},{"last_name":"Nitta","first_name":"Noritaka","full_name":"Nitta, Noritaka"},{"first_name":"Tsuneyuki","last_name":"Koga","full_name":"Koga, Tsuneyuki"},{"orcid":"0000-0001-8761-9444","id":"499F3ABC-F248-11E8-B48F-1D18A9856A87","last_name":"Shigemoto","first_name":"Ryuichi","full_name":"Shigemoto, Ryuichi"},{"last_name":"Takai","first_name":"Toshiyuki","full_name":"Takai, Toshiyuki"},{"last_name":"Ito","first_name":"Isao","full_name":"Ito, Isao"}],"scopus_import":1,"has_accepted_license":"1","day":"01","article_type":"original","citation":{"chicago":"Ukai, Hikari, Aiko Kawahara, Keiko Hirayama, Matthew J Case, Shotaro Aino, Masahiro Miyabe, Ken Wakita, et al. “PirB Regulates Asymmetries in Hippocampal Circuitry.” PLoS One. Public Library of Science, 2017. https://doi.org/10.1371/journal.pone.0179377.","mla":"Ukai, Hikari, et al. “PirB Regulates Asymmetries in Hippocampal Circuitry.” PLoS One, vol. 12, no. 6, e0179377, Public Library of Science, 2017, doi:10.1371/journal.pone.0179377.","short":"H. Ukai, A. Kawahara, K. Hirayama, M.J. Case, S. Aino, M. Miyabe, K. Wakita, R. Oogi, M. Kasayuki, S. Kawashima, S. Sugimoto, K. Chikamatsu, N. Nitta, T. Koga, R. Shigemoto, T. Takai, I. Ito, PLoS One 12 (2017).","ista":"Ukai H, Kawahara A, Hirayama K, Case MJ, Aino S, Miyabe M, Wakita K, Oogi R, Kasayuki M, Kawashima S, Sugimoto S, Chikamatsu K, Nitta N, Koga T, Shigemoto R, Takai T, Ito I. 2017. PirB regulates asymmetries in hippocampal circuitry. PLoS One. 12(6), e0179377.","apa":"Ukai, H., Kawahara, A., Hirayama, K., Case, M. J., Aino, S., Miyabe, M., … Ito, I. (2017). PirB regulates asymmetries in hippocampal circuitry. PLoS One. Public Library of Science. https://doi.org/10.1371/journal.pone.0179377","ieee":"H. Ukai et al., “PirB regulates asymmetries in hippocampal circuitry,” PLoS One, vol. 12, no. 6. Public Library of Science, 2017.","ama":"Ukai H, Kawahara A, Hirayama K, et al. PirB regulates asymmetries in hippocampal circuitry. PLoS One. 2017;12(6). doi:10.1371/journal.pone.0179377"},"publication":"PLoS One","date_published":"2017-06-01T00:00:00Z","type":"journal_article","issue":"6","abstract":[{"text":"Left-right asymmetry is a fundamental feature of higher-order brain structure; however, the molecular basis of brain asymmetry remains unclear. We recently identified structural and functional asymmetries in mouse hippocampal circuitry that result from the asymmetrical distribution of two distinct populations of pyramidal cell synapses that differ in the density of the NMDA receptor subunit GluRε2 (also known as NR2B, GRIN2B or GluN2B). By examining the synaptic distribution of ε2 subunits, we previously found that β2-microglobulin-deficient mice, which lack cell surface expression of the vast majority of major histocompatibility complex class I (MHCI) proteins, do not exhibit circuit asymmetry. In the present study, we conducted electrophysiological and anatomical analyses on the hippocampal circuitry of mice with a knockout of the paired immunoglobulin-like receptor B (PirB), an MHCI receptor. As in β2-microglobulin-deficient mice, the PirB-deficient hippocampus lacked circuit asymmetries. This finding that MHCI loss-of-function mice and PirB knockout mice have identical phenotypes suggests that MHCI signals that produce hippocampal asymmetries are transduced through PirB. Our results provide evidence for a critical role of the MHCI/PirB signaling system in the generation of asymmetries in hippocampal circuitry.","lang":"eng"}],"intvolume":" 12","ddc":["571"],"status":"public","title":"PirB regulates asymmetries in hippocampal circuitry","_id":"682","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","file":[{"date_created":"2018-12-12T10:12:16Z","date_updated":"2020-07-14T12:47:40Z","checksum":"24dd19c46fb1c761b0bcbbcd1025a3a8","file_id":"4934","relation":"main_file","creator":"system","file_size":5798454,"content_type":"application/pdf","file_name":"IST-2017-897-v1+1_journal.pone.0179377.pdf","access_level":"open_access"}],"oa_version":"Published Version","pubrep_id":"897"},{"publisher":"Wiley-Blackwell","department":[{"_id":"CaGu"},{"_id":"HaJa"}],"publication_status":"published","year":"2017","acknowledgement":"This work was supported by a grant from the European Unions Seventh Framework Programme (CIG-303564). E.R. was supported by the graduate program MolecularDrugTargets (Austrian Science Fund (FWF), W1232) and a FemTech fellowship (Austrian Research Promotion Agency, 3580812)","volume":56,"date_updated":"2024-03-28T23:30:13Z","date_created":"2018-12-11T11:49:46Z","related_material":{"record":[{"id":"418","relation":"dissertation_contains","status":"public"},{"id":"7680","relation":"part_of_dissertation","status":"public"}]},"author":[{"id":"32CFBA64-F248-11E8-B48F-1D18A9856A87","first_name":"Stephanie","last_name":"Kainrath","full_name":"Kainrath, Stephanie"},{"last_name":"Stadler","first_name":"Manuela","full_name":"Stadler, Manuela"},{"id":"3FEE232A-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-7218-7738","first_name":"Eva","last_name":"Gschaider-Reichhart","full_name":"Gschaider-Reichhart, Eva"},{"last_name":"Distel","first_name":"Martin","full_name":"Distel, Martin"},{"id":"33BA6C30-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-8023-9315","first_name":"Harald L","last_name":"Janovjak","full_name":"Janovjak, Harald L"}],"publist_id":"6362","ec_funded":1,"file_date_updated":"2019-01-18T09:39:55Z","project":[{"grant_number":"303564","_id":"25548C20-B435-11E9-9278-68D0E5697425","name":"Microbial Ion Channels for Synthetic Neurobiology","call_identifier":"FP7"},{"grant_number":"W1232-B24","_id":"26AA4EF2-B435-11E9-9278-68D0E5697425","call_identifier":"FWF","name":"Molecular Drug Targets [do not use to be deleted]"}],"quality_controlled":"1","isi":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"external_id":{"isi":["000398154000038"]},"oa":1,"language":[{"iso":"eng"}],"doi":"10.1002/anie.201611998","publication_identifier":{"issn":["14337851"]},"month":"03","intvolume":" 56","ddc":["540"],"title":"Green-light-induced inactivation of receptor signaling using cobalamin-binding domains","status":"public","user_id":"c635000d-4b10-11ee-a964-aac5a93f6ac1","_id":"1028","file":[{"access_level":"open_access","file_name":"2017_communications_Kainrath.pdf","creator":"dernst","content_type":"application/pdf","file_size":2614942,"file_id":"5845","relation":"main_file","success":1,"date_updated":"2019-01-18T09:39:55Z","date_created":"2019-01-18T09:39:55Z"}],"oa_version":"Published Version","type":"journal_article","issue":"16","abstract":[{"lang":"eng","text":"Optogenetics and photopharmacology provide spatiotemporally precise control over protein interactions and protein function in cells and animals. Optogenetic methods that are sensitive to green light and can be used to break protein complexes are not broadly available but would enable multichromatic experiments with previously inaccessible biological targets. Herein, we repurposed cobalamin (vitamin B12) binding domains of bacterial CarH transcription factors for green-light-induced receptor dissociation. In cultured cells, we observed oligomerization-induced cell signaling for the fibroblast growth factor receptor 1 fused to cobalamin-binding domains in the dark that was rapidly eliminated upon illumination. In zebrafish embryos expressing fusion receptors, green light endowed control over aberrant fibroblast growth factor signaling during development. Green-light-induced domain dissociation and light-inactivated receptors will critically expand the optogenetic toolbox for control of biological processes."}],"page":"4608-4611","citation":{"mla":"Kainrath, Stephanie, et al. “Green-Light-Induced Inactivation of Receptor Signaling Using Cobalamin-Binding Domains.” Angewandte Chemie - International Edition, vol. 56, no. 16, Wiley-Blackwell, 2017, pp. 4608–11, doi:10.1002/anie.201611998.","short":"S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie - International Edition 56 (2017) 4608–4611.","chicago":"Kainrath, Stephanie, Manuela Stadler, Eva Gschaider-Reichhart, Martin Distel, and Harald L Janovjak. “Green-Light-Induced Inactivation of Receptor Signaling Using Cobalamin-Binding Domains.” Angewandte Chemie - International Edition. Wiley-Blackwell, 2017. https://doi.org/10.1002/anie.201611998.","ama":"Kainrath S, Stadler M, Gschaider-Reichhart E, Distel M, Janovjak HL. Green-light-induced inactivation of receptor signaling using cobalamin-binding domains. Angewandte Chemie - International Edition. 2017;56(16):4608-4611. doi:10.1002/anie.201611998","ista":"Kainrath S, Stadler M, Gschaider-Reichhart E, Distel M, Janovjak HL. 2017. Green-light-induced inactivation of receptor signaling using cobalamin-binding domains. Angewandte Chemie - International Edition. 56(16), 4608–4611.","apa":"Kainrath, S., Stadler, M., Gschaider-Reichhart, E., Distel, M., & Janovjak, H. L. (2017). Green-light-induced inactivation of receptor signaling using cobalamin-binding domains. Angewandte Chemie - International Edition. Wiley-Blackwell. https://doi.org/10.1002/anie.201611998","ieee":"S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, and H. L. Janovjak, “Green-light-induced inactivation of receptor signaling using cobalamin-binding domains,” Angewandte Chemie - International Edition, vol. 56, no. 16. Wiley-Blackwell, pp. 4608–4611, 2017."},"publication":"Angewandte Chemie - International Edition","date_published":"2017-03-20T00:00:00Z","scopus_import":"1","has_accepted_license":"1","article_processing_charge":"No","day":"20"},{"citation":{"ama":"Hurny A, Benková E. Methodological advances in auxin and cytokinin biology. Auxins and Cytokinins in Plant Biology. 2017;1569:1-29. doi:10.1007/978-1-4939-6831-2_1","ista":"Hurny A, Benková E. 2017. Methodological advances in auxin and cytokinin biology. Auxins and Cytokinins in Plant Biology. 1569, 1–29.","ieee":"A. Hurny and E. Benková, “Methodological advances in auxin and cytokinin biology,” Auxins and Cytokinins in Plant Biology, vol. 1569. Springer, pp. 1–29, 2017.","apa":"Hurny, A., & Benková, E. (2017). Methodological advances in auxin and cytokinin biology. Auxins and Cytokinins in Plant Biology. Springer. https://doi.org/10.1007/978-1-4939-6831-2_1","mla":"Hurny, Andrej, and Eva Benková. “Methodological Advances in Auxin and Cytokinin Biology.” Auxins and Cytokinins in Plant Biology, vol. 1569, Springer, 2017, pp. 1–29, doi:10.1007/978-1-4939-6831-2_1.","short":"A. Hurny, E. Benková, Auxins and Cytokinins in Plant Biology 1569 (2017) 1–29.","chicago":"Hurny, Andrej, and Eva Benková. “Methodological Advances in Auxin and Cytokinin Biology.” Auxins and Cytokinins in Plant Biology. Springer, 2017. https://doi.org/10.1007/978-1-4939-6831-2_1."},"publication":"Auxins and Cytokinins in Plant Biology","page":"1 - 29","date_published":"2017-03-17T00:00:00Z","scopus_import":1,"has_accepted_license":"1","day":"17","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"1024","intvolume":" 1569","title":"Methodological advances in auxin and cytokinin biology","ddc":["575"],"status":"public","pubrep_id":"1019","oa_version":"Submitted Version","file":[{"access_level":"open_access","file_name":"IST-2018-1019-v1+1_Hurny_MethodsMolBiol_2017.pdf","content_type":"application/pdf","file_size":840646,"creator":"system","relation":"main_file","file_id":"5068","date_created":"2018-12-12T10:14:18Z","date_updated":"2019-10-15T07:47:05Z"}],"type":"journal_article","alternative_title":["Methods in Molecular Biology"],"abstract":[{"text":"The history of auxin and cytokinin biology including the initial discoveries by father–son duo Charles Darwin and Francis Darwin (1880), and Gottlieb Haberlandt (1919) is a beautiful demonstration of unceasing continuity of research. Novel findings are integrated into existing hypotheses and models and deepen our understanding of biological principles. At the same time new questions are triggered and hand to hand with this new methodologies are developed to address these new challenges.","lang":"eng"}],"oa":1,"project":[{"name":"Hormone cross-talk drives nutrient dependent plant development","call_identifier":"FWF","grant_number":"I 1774-B16","_id":"2542D156-B435-11E9-9278-68D0E5697425"}],"quality_controlled":"1","doi":"10.1007/978-1-4939-6831-2_1","language":[{"iso":"eng"}],"publication_identifier":{"issn":["10643745"]},"month":"03","year":"2017","publisher":"Springer","department":[{"_id":"EvBe"}],"publication_status":"published","related_material":{"record":[{"id":"539","status":"public","relation":"dissertation_contains"}]},"author":[{"orcid":"0000-0003-3638-1426","id":"4DC4AF46-F248-11E8-B48F-1D18A9856A87","last_name":"Hurny","first_name":"Andrej","full_name":"Hurny, Andrej"},{"full_name":"Benková, Eva","last_name":"Benková","first_name":"Eva","orcid":"0000-0002-8510-9739","id":"38F4F166-F248-11E8-B48F-1D18A9856A87"}],"volume":1569,"date_updated":"2024-03-28T23:30:17Z","date_created":"2018-12-11T11:49:45Z","publist_id":"6369","file_date_updated":"2019-10-15T07:47:05Z"},{"date_updated":"2024-03-28T23:30:23Z","date_created":"2018-12-11T11:47:53Z","volume":127,"author":[{"full_name":"Ebner, Florian","last_name":"Ebner","first_name":"Florian"},{"full_name":"Sedlyarov, Vitaly","first_name":"Vitaly","last_name":"Sedlyarov"},{"id":"4323B49C-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1671-393X","first_name":"Saren","last_name":"Tasciyan","full_name":"Tasciyan, Saren"},{"full_name":"Ivin, Masa","last_name":"Ivin","first_name":"Masa"},{"first_name":"Franz","last_name":"Kratochvill","full_name":"Kratochvill, Franz"},{"full_name":"Gratz, Nina","first_name":"Nina","last_name":"Gratz"},{"last_name":"Kenner","first_name":"Lukas","full_name":"Kenner, Lukas"},{"last_name":"Villunger","first_name":"Andreas","full_name":"Villunger, Andreas"},{"orcid":"0000-0002-6620-9179","id":"41E9FBEA-F248-11E8-B48F-1D18A9856A87","last_name":"Sixt","first_name":"Michael K","full_name":"Sixt, Michael K"},{"last_name":"Kovarik","first_name":"Pavel","full_name":"Kovarik, Pavel"}],"related_material":{"record":[{"relation":"dissertation_contains","status":"public","id":"12401"}]},"publication_status":"published","department":[{"_id":"MiSi"}],"publisher":"American Society for Clinical Investigation","acknowledgement":"This work was supported by grants from the Austrian Science Fund (FWF) (P27538-B21, I1621-B22, and SFB 43, to PK); by funding from the European Union Seventh Framework Programme Marie Curie Initial Training Networks (FP7-PEOPLE-2012-ITN) for the project INBIONET (INfection BIOlogy Training NETwork under grant agreement PITN-GA-2012-316682; and by a joint research cluster initiative of the University of Vienna and the Medical University of Vienna.","year":"2017","pmid":1,"publist_id":"7038","language":[{"iso":"eng"}],"doi":"10.1172/JCI80631","quality_controlled":"1","project":[{"call_identifier":"FWF","name":"The biochemical basis of PAR polarization","grant_number":"T00817-B21","_id":"25985A36-B435-11E9-9278-68D0E5697425"},{"_id":"25E9AF9E-B435-11E9-9278-68D0E5697425","grant_number":"P27201-B22","name":"Revealing the mechanisms underlying drug interactions","call_identifier":"FWF"}],"external_id":{"pmid":["28504646"]},"main_file_link":[{"open_access":"1","url":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5451238/"}],"oa":1,"month":"06","publication_identifier":{"issn":["00219738"]},"oa_version":"Submitted Version","title":"The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection","status":"public","intvolume":" 127","_id":"679","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","abstract":[{"text":"Protective responses against pathogens require a rapid mobilization of resting neutrophils and the timely removal of activated ones. Neutrophils are exceptionally short-lived leukocytes, yet it remains unclear whether the lifespan of pathogen-engaged neutrophils is regulated differently from that in the circulating steady-state pool. Here, we have found that under homeostatic conditions, the mRNA-destabilizing protein tristetraprolin (TTP) regulates apoptosis and the numbers of activated infiltrating murine neutrophils but not neutrophil cellularity. Activated TTP-deficient neutrophils exhibited decreased apoptosis and enhanced accumulation at the infection site. In the context of myeloid-specific deletion of Ttp, the potentiation of neutrophil deployment protected mice against lethal soft tissue infection with Streptococcus pyogenes and prevented bacterial dissemination. Neutrophil transcriptome analysis revealed that decreased apoptosis of TTP-deficient neutrophils was specifically associated with elevated expression of myeloid cell leukemia 1 (Mcl1) but not other antiapoptotic B cell leukemia/ lymphoma 2 (Bcl2) family members. Higher Mcl1 expression resulted from stabilization of Mcl1 mRNA in the absence of TTP. The low apoptosis rate of infiltrating TTP-deficient neutrophils was comparable to that of transgenic Mcl1-overexpressing neutrophils. Our study demonstrates that posttranscriptional gene regulation by TTP schedules the termination of the antimicrobial engagement of neutrophils. The balancing role of TTP comes at the cost of an increased risk of bacterial infections.","lang":"eng"}],"issue":"6","type":"journal_article","date_published":"2017-06-01T00:00:00Z","page":"2051 - 2065","publication":"The Journal of Clinical Investigation","citation":{"short":"F. Ebner, V. Sedlyarov, S. Tasciyan, M. Ivin, F. Kratochvill, N. Gratz, L. Kenner, A. Villunger, M.K. Sixt, P. Kovarik, The Journal of Clinical Investigation 127 (2017) 2051–2065.","mla":"Ebner, Florian, et al. “The RNA-Binding Protein Tristetraprolin Schedules Apoptosis of Pathogen-Engaged Neutrophils during Bacterial Infection.” The Journal of Clinical Investigation, vol. 127, no. 6, American Society for Clinical Investigation, 2017, pp. 2051–65, doi:10.1172/JCI80631.","chicago":"Ebner, Florian, Vitaly Sedlyarov, Saren Tasciyan, Masa Ivin, Franz Kratochvill, Nina Gratz, Lukas Kenner, Andreas Villunger, Michael K Sixt, and Pavel Kovarik. “The RNA-Binding Protein Tristetraprolin Schedules Apoptosis of Pathogen-Engaged Neutrophils during Bacterial Infection.” The Journal of Clinical Investigation. American Society for Clinical Investigation, 2017. https://doi.org/10.1172/JCI80631.","ama":"Ebner F, Sedlyarov V, Tasciyan S, et al. The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection. The Journal of Clinical Investigation. 2017;127(6):2051-2065. doi:10.1172/JCI80631","ieee":"F. Ebner et al., “The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection,” The Journal of Clinical Investigation, vol. 127, no. 6. American Society for Clinical Investigation, pp. 2051–2065, 2017.","apa":"Ebner, F., Sedlyarov, V., Tasciyan, S., Ivin, M., Kratochvill, F., Gratz, N., … Kovarik, P. (2017). The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection. The Journal of Clinical Investigation. American Society for Clinical Investigation. https://doi.org/10.1172/JCI80631","ista":"Ebner F, Sedlyarov V, Tasciyan S, Ivin M, Kratochvill F, Gratz N, Kenner L, Villunger A, Sixt MK, Kovarik P. 2017. The RNA-binding protein tristetraprolin schedules apoptosis of pathogen-engaged neutrophils during bacterial infection. The Journal of Clinical Investigation. 127(6), 2051–2065."},"day":"01","scopus_import":1},{"publication_identifier":{"issn":["09501991"]},"month":"05","language":[{"iso":"eng"}],"doi":"10.1242/dev.144964","quality_controlled":"1","tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"external_id":{"pmid":["28512197"]},"oa":1,"publist_id":"7047","file_date_updated":"2020-07-14T12:47:39Z","volume":144,"date_updated":"2024-03-28T23:30:26Z","date_created":"2018-12-11T11:47:52Z","related_material":{"record":[{"status":"public","relation":"dissertation_contains","id":"961"},{"id":"50","status":"public","relation":"dissertation_contains"}]},"author":[{"last_name":"Krens","first_name":"Gabriel","orcid":"0000-0003-4761-5996","id":"2B819732-F248-11E8-B48F-1D18A9856A87","full_name":"Krens, Gabriel"},{"full_name":"Veldhuis, Jim","last_name":"Veldhuis","first_name":"Jim"},{"last_name":"Barone","first_name":"Vanessa","orcid":"0000-0003-2676-3367","id":"419EECCC-F248-11E8-B48F-1D18A9856A87","full_name":"Barone, Vanessa"},{"first_name":"Daniel","last_name":"Capek","id":"31C42484-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0001-5199-9940","full_name":"Capek, Daniel"},{"id":"48F1E0D8-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-3688-1474","first_name":"Jean-Léon","last_name":"Maître","full_name":"Maître, Jean-Léon"},{"full_name":"Brodland, Wayne","first_name":"Wayne","last_name":"Brodland"},{"full_name":"Heisenberg, Carl-Philipp J","first_name":"Carl-Philipp J","last_name":"Heisenberg","id":"39427864-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0002-0912-4566"}],"publisher":"Company of Biologists","department":[{"_id":"Bio"},{"_id":"CaHe"}],"publication_status":"published","pmid":1,"year":"2017","has_accepted_license":"1","article_processing_charge":"No","day":"15","scopus_import":1,"date_published":"2017-05-15T00:00:00Z","page":"1798 - 1806","article_type":"original","citation":{"ista":"Krens G, Veldhuis J, Barone V, Capek D, Maître J-L, Brodland W, Heisenberg C-PJ. 2017. Interstitial fluid osmolarity modulates the action of differential tissue surface tension in progenitor cell segregation during gastrulation. Development. 144(10), 1798–1806.","ieee":"G. Krens et al., “Interstitial fluid osmolarity modulates the action of differential tissue surface tension in progenitor cell segregation during gastrulation,” Development, vol. 144, no. 10. Company of Biologists, pp. 1798–1806, 2017.","apa":"Krens, G., Veldhuis, J., Barone, V., Capek, D., Maître, J.-L., Brodland, W., & Heisenberg, C.-P. J. (2017). Interstitial fluid osmolarity modulates the action of differential tissue surface tension in progenitor cell segregation during gastrulation. Development. Company of Biologists. https://doi.org/10.1242/dev.144964","ama":"Krens G, Veldhuis J, Barone V, et al. Interstitial fluid osmolarity modulates the action of differential tissue surface tension in progenitor cell segregation during gastrulation. Development. 2017;144(10):1798-1806. doi:10.1242/dev.144964","chicago":"Krens, Gabriel, Jim Veldhuis, Vanessa Barone, Daniel Capek, Jean-Léon Maître, Wayne Brodland, and Carl-Philipp J Heisenberg. “Interstitial Fluid Osmolarity Modulates the Action of Differential Tissue Surface Tension in Progenitor Cell Segregation during Gastrulation.” Development. Company of Biologists, 2017. https://doi.org/10.1242/dev.144964.","mla":"Krens, Gabriel, et al. “Interstitial Fluid Osmolarity Modulates the Action of Differential Tissue Surface Tension in Progenitor Cell Segregation during Gastrulation.” Development, vol. 144, no. 10, Company of Biologists, 2017, pp. 1798–806, doi:10.1242/dev.144964.","short":"G. Krens, J. Veldhuis, V. Barone, D. Capek, J.-L. Maître, W. Brodland, C.-P.J. Heisenberg, Development 144 (2017) 1798–1806."},"publication":"Development","issue":"10","abstract":[{"text":"The segregation of different cell types into distinct tissues is a fundamental process in metazoan development. Differences in cell adhesion and cortex tension are commonly thought to drive cell sorting by regulating tissue surface tension (TST). However, the role that differential TST plays in cell segregation within the developing embryo is as yet unclear. Here, we have analyzed the role of differential TST for germ layer progenitor cell segregation during zebrafish gastrulation. Contrary to previous observations that differential TST drives germ layer progenitor cell segregation in vitro, we show that germ layers display indistinguishable TST within the gastrulating embryo, arguing against differential TST driving germ layer progenitor cell segregation in vivo. We further show that the osmolarity of the interstitial fluid (IF) is an important factor that influences germ layer TST in vivo, and that lower osmolarity of the IF compared with standard cell culture medium can explain why germ layers display differential TST in culture but not in vivo. Finally, we show that directed migration of mesendoderm progenitors is required for germ layer progenitor cell segregation and germ layer formation.","lang":"eng"}],"type":"journal_article","oa_version":"Published Version","file":[{"access_level":"open_access","file_name":"2017_Development_Krens.pdf","file_size":8194516,"content_type":"application/pdf","creator":"dernst","relation":"main_file","file_id":"6905","checksum":"bc25125fb664706cdf180e061429f91d","date_created":"2019-09-24T06:56:22Z","date_updated":"2020-07-14T12:47:39Z"}],"intvolume":" 144","title":"Interstitial fluid osmolarity modulates the action of differential tissue surface tension in progenitor cell segregation during gastrulation","status":"public","ddc":["570"],"_id":"676","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87"},{"article_number":"e25100","file_date_updated":"2020-07-14T12:47:48Z","publist_id":"6990","publication_status":"published","department":[{"_id":"CaGu"}],"publisher":"eLife Sciences Publications","year":"2017","date_created":"2018-12-11T11:48:01Z","date_updated":"2024-03-28T23:30:28Z","volume":6,"author":[{"full_name":"Steinrück, Magdalena","first_name":"Magdalena","last_name":"Steinrück","id":"2C023F40-F248-11E8-B48F-1D18A9856A87","orcid":"0000-0003-1229-9719"},{"last_name":"Guet","first_name":"Calin C","orcid":"0000-0001-6220-2052","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","full_name":"Guet, Calin C"}],"related_material":{"record":[{"status":"public","relation":"popular_science","id":"5564"},{"status":"public","relation":"dissertation_contains","id":"26"}]},"month":"07","publication_identifier":{"issn":["2050084X"]},"quality_controlled":"1","oa":1,"tmp":{"name":"Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)","legal_code_url":"https://creativecommons.org/licenses/by/4.0/legalcode","short":"CC BY (4.0)","image":"/images/cc_by.png"},"language":[{"iso":"eng"}],"doi":"10.7554/eLife.25100","type":"journal_article","abstract":[{"lang":"eng","text":"How the organization of genes on a chromosome shapes adaptation is essential for understanding evolutionary paths. Here, we investigate how adaptation to rapidly increasing levels of antibiotic depends on the chromosomal neighborhood of a drug-resistance gene inserted at different positions of the Escherichia coli chromosome. Using a dual-fluorescence reporter that allows us to distinguish gene amplifications from other up-mutations, we track in real-time adaptive changes in expression of the drug-resistance gene. We find that the relative contribution of several mutation types differs systematically between loci due to properties of neighboring genes: essentiality, expression, orientation, termination, and presence of duplicates. These properties determine rate and fitness effects of gene amplification, deletions, and mutations compromising transcriptional termination. Thus, the adaptive potential of a gene under selection is a system-property with a complex genetic basis that is specific for each chromosomal locus, and it can be inferred from detailed functional and genomic data."}],"status":"public","ddc":["576"],"title":"Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection","intvolume":" 6","user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","_id":"704","file":[{"file_size":2092088,"content_type":"application/pdf","creator":"system","file_name":"IST-2017-890-v1+1_elife-25100-v1.pdf","access_level":"open_access","date_created":"2018-12-12T10:12:54Z","date_updated":"2020-07-14T12:47:48Z","checksum":"6b908b5db9f61f6820ebd7f8fa815571","relation":"main_file","file_id":"4975"},{"file_size":3428681,"content_type":"application/pdf","creator":"system","access_level":"open_access","file_name":"IST-2017-890-v1+2_elife-25100-figures-v1.pdf","checksum":"ca21530389b720243552678125fdba35","date_created":"2018-12-12T10:12:55Z","date_updated":"2020-07-14T12:47:48Z","relation":"main_file","file_id":"4976"}],"oa_version":"Published Version","pubrep_id":"890","scopus_import":1,"day":"25","has_accepted_license":"1","publication":"eLife","citation":{"chicago":"Steinrück, Magdalena, and Calin C Guet. “Complex Chromosomal Neighborhood Effects Determine the Adaptive Potential of a Gene under Selection.” ELife. eLife Sciences Publications, 2017. https://doi.org/10.7554/eLife.25100.","mla":"Steinrück, Magdalena, and Calin C. Guet. “Complex Chromosomal Neighborhood Effects Determine the Adaptive Potential of a Gene under Selection.” ELife, vol. 6, e25100, eLife Sciences Publications, 2017, doi:10.7554/eLife.25100.","short":"M. Steinrück, C.C. Guet, ELife 6 (2017).","ista":"Steinrück M, Guet CC. 2017. Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection. eLife. 6, e25100.","ieee":"M. Steinrück and C. C. Guet, “Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection,” eLife, vol. 6. eLife Sciences Publications, 2017.","apa":"Steinrück, M., & Guet, C. C. (2017). Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection. ELife. eLife Sciences Publications. https://doi.org/10.7554/eLife.25100","ama":"Steinrück M, Guet CC. Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection. eLife. 2017;6. doi:10.7554/eLife.25100"},"date_published":"2017-07-25T00:00:00Z"}]