@article{6835, abstract = {We derive the Hasse principle and weak approximation for fibrations of certain varieties in the spirit of work by Colliot-Thélène–Sansuc and Harpaz–Skorobogatov–Wittenberg. Our varieties are defined through polynomials in many variables and part of our work is devoted to establishing Schinzel's hypothesis for polynomials of this kind. This last part is achieved by using arguments behind Birch's well-known result regarding the Hasse principle for complete intersections with the notable difference that we prove our result in 50% fewer variables than in the classical Birch setting. We also study the problem of square-free values of an integer polynomial with 66.6% fewer variables than in the Birch setting.}, author = {Destagnol, Kevin N and Sofos, Efthymios}, issn = {0007-4497}, journal = {Bulletin des Sciences Mathematiques}, number = {11}, publisher = {Elsevier}, title = {{Rational points and prime values of polynomials in moderately many variables}}, doi = {10.1016/j.bulsci.2019.102794}, volume = {156}, year = {2019}, } @article{6837, abstract = {Migrasomes are a recently discovered type of extracellular vesicles that are characteristically generated along retraction fibers in migrating cells. Two studies now show how migrasomes are formed and how they function in the physiologically relevant context of the developing zebrafish embryo.}, author = {Tavano, Ste and Heisenberg, Carl-Philipp J}, issn = {1476-4679}, journal = {Nature Cell Biology}, number = {8}, pages = {918--920}, publisher = {Springer Nature}, title = {{Migrasomes take center stage}}, doi = {10.1038/s41556-019-0369-3}, volume = {21}, year = {2019}, } @article{6867, abstract = {A novel magnetic scratch method achieves repeatability, reproducibility and geometric control greater than pipette scratch assays and closely approximating the precision of cell exclusion assays while inducing the cell injury inherently necessary for wound healing assays. The magnetic scratch is affordable, easily implemented and standardisable and thus may contribute toward better comparability of data generated in different studies and laboratories.}, author = {Fenu, M. and Bettermann, T. and Vogl, C. and Darwish-Miranda, Nasser and Schramel, J. and Jenner, F. and Ribitsch, I.}, issn = {20452322}, journal = {Scientific Reports}, number = {1}, publisher = {Springer Nature}, title = {{A novel magnet-based scratch method for standardisation of wound-healing assays}}, doi = {10.1038/s41598-019-48930-7}, volume = {9}, year = {2019}, } @article{6859, abstract = {V (vacuolar)/A (archaeal)-type adenosine triphosphatases (ATPases), found in archaeaand eubacteria, couple ATP hydrolysis or synthesis to proton translocation across theplasma membrane using the rotary-catalysis mechanism. They belong to the V-typeATPase family, which differs from the mitochondrial/chloroplast F-type ATP synthasesin overall architecture. We solved cryo–electron microscopy structures of the intactThermus thermophilusV/A-ATPase, reconstituted into lipid nanodiscs, in three rotationalstates and two substates. These structures indicate substantial flexibility betweenV1and Voin a working enzyme, which results from mechanical competition between centralshaft rotation and resistance from the peripheral stalks. We also describedetails of adenosine diphosphate inhibition release, V1-Votorque transmission, andproton translocation, which are relevant for the entire V-type ATPase family.}, author = {Zhou, Long and Sazanov, Leonid A}, issn = {1095-9203}, journal = {Science}, number = {6455}, publisher = {AAAS}, title = {{Structure and conformational plasticity of the intact Thermus thermophilus V/A-type ATPase}}, doi = {10.1126/science.aaw9144}, volume = {365}, year = {2019}, } @article{6858, author = {Barton, Nicholas H}, issn = {2053-714X}, journal = {National Science Review}, number = {2}, pages = {291--292}, publisher = {Oxford University Press}, title = {{Is speciation driven by cycles of mixing and isolation?}}, doi = {10.1093/nsr/nwy113}, volume = {6}, year = {2019}, }