TY - JOUR AB - Motivated by the recent introduction of the intrinsic semilattice entropy, we study generalized quasi-metric semilattices and their categories. We investigate the relationship between these objects and generalized semivaluations, extending Nakamura and Schellekens' approach. Finally, we use this correspondence to compare the intrinsic semilattice entropy and the semigroup entropy induced in particular situations, like sets, torsion abelian groups and vector spaces. AU - Dikranjan, Dikran AU - Giordano Bruno, Anna AU - Künzi, Hans Peter AU - Zava, Nicolò AU - Toller, Daniele ID - 10413 JF - Topology and its Applications SN - 0166-8641 TI - Generalized quasi-metric semilattices VL - 309 ER - TY - JOUR AB - The Voronoi tessellation in Rd is defined by locally minimizing the power distance to given weighted points. Symmetrically, the Delaunay mosaic can be defined by locally maximizing the negative power distance to other such points. We prove that the average of the two piecewise quadratic functions is piecewise linear, and that all three functions have the same critical points and values. Discretizing the two piecewise quadratic functions, we get the alpha shapes as sublevel sets of the discrete function on the Delaunay mosaic, and analogous shapes as superlevel sets of the discrete function on the Voronoi tessellation. For the same non-critical value, the corresponding shapes are disjoint, separated by a narrow channel that contains no critical points but the entire level set of the piecewise linear function. AU - Biswas, Ranita AU - Cultrera Di Montesano, Sebastiano AU - Edelsbrunner, Herbert AU - Saghafian, Morteza ID - 10773 JF - Discrete and Computational Geometry SN - 0179-5376 TI - Continuous and discrete radius functions on Voronoi tessellations and Delaunay mosaics VL - 67 ER - TY - CONF AB - Digital images enable quantitative analysis of material properties at micro and macro length scales, but choosing an appropriate resolution when acquiring the image is challenging. A high resolution means longer image acquisition and larger data requirements for a given sample, but if the resolution is too low, significant information may be lost. This paper studies the impact of changes in resolution on persistent homology, a tool from topological data analysis that provides a signature of structure in an image across all length scales. Given prior information about a function, the geometry of an object, or its density distribution at a given resolution, we provide methods to select the coarsest resolution yielding results within an acceptable tolerance. We present numerical case studies for an illustrative synthetic example and samples from porous materials where the theoretical bounds are unknown. AU - Heiss, Teresa AU - Tymochko, Sarah AU - Story, Brittany AU - Garin, Adélie AU - Bui, Hoa AU - Bleile, Bea AU - Robins, Vanessa ID - 10828 SN - 9781665439022 T2 - 2021 IEEE International Conference on Big Data TI - The impact of changes in resolution on the persistent homology of images ER - TY - JOUR AB - We classify contravariant pairings between standard Whittaker modules and Verma modules over a complex semisimple Lie algebra. These contravariant pairings are useful in extending several classical techniques for category O to the Miličić–Soergel category N . We introduce a class of costandard modules which generalize dual Verma modules, and describe canonical maps from standard to costandard modules in terms of contravariant pairings. We show that costandard modules have unique irreducible submodules and share the same composition factors as the corresponding standard Whittaker modules. We show that costandard modules give an algebraic characterization of the global sections of costandard twisted Harish-Chandra sheaves on the associated flag variety, which are defined using holonomic duality of D-modules. We prove that with these costandard modules, blocks of category N have the structure of highest weight categories and we establish a BGG reciprocity theorem for N . AU - Brown, Adam AU - Romanov, Anna ID - 11545 IS - 11 JF - Journal of Algebra KW - Algebra and Number Theory SN - 0021-8693 TI - Contravariant pairings between standard Whittaker modules and Verma modules VL - 609 ER - TY - JOUR AB - Targeting dysregulated Ca2+ signaling in cancer cells is an emerging chemotherapy approach. We previously reported that store-operated Ca2+ entry (SOCE) blockers, such as RP4010, are promising antitumor drugs for esophageal cancer. As a tyrosine kinase inhibitor (TKI), afatinib received FDA approval to be used in targeted therapy for patients with EGFR mutation-positive cancers. While preclinical studies and clinical trials have shown that afatinib has benefits for esophageal cancer patients, it is not known whether a combination of afatinib and RP4010 could achieve better anticancer effects. Since TKI can alter intracellular Ca2+ dynamics through EGFR/phospholipase C-γ pathway, in this study, we evaluated the inhibitory effect of afatinib and RP4010 on intracellular Ca2+ oscillations in KYSE-150, a human esophageal squamous cell carcinoma cell line, using both experimental and mathematical simulations. Our mathematical simulation of Ca2+ oscillations could fit well with experimental data responding to afatinib or RP4010, both separately or in combination. Guided by simulation, we were able to identify a proper ratio of afatinib and RP4010 for combined treatment, and such a combination presented synergistic anticancer-effect evidence by experimental measurement of intracellular Ca2+ and cell proliferation. This intracellular Ca2+ dynamic-based mathematical simulation approach could be useful for a rapid and cost-effective evaluation of combined targeting therapy drugs. AU - Chang, Yan AU - Funk, Marah AU - Roy, Souvik AU - Stephenson, Elizabeth R AU - Choi, Sangyong AU - Kojouharov, Hristo V. AU - Chen, Benito AU - Pan, Zui ID - 10754 IS - 3 JF - International Journal of Molecular Sciences SN - 16616596 TI - Developing a mathematical model of intracellular Calcium dynamics for evaluating combined anticancer effects of afatinib and RP4010 in esophageal cancer VL - 23 ER - TY - JOUR AB - Extending a result of Milena Radnovic and Serge Tabachnikov, we establish conditionsfor two different non-symmetric norms to define the same billiard reflection law. AU - Akopyan, Arseniy AU - Karasev, Roman ID - 7791 IS - 4 JF - European Journal of Mathematics SN - 2199-675X TI - When different norms lead to same billiard trajectories? VL - 8 ER - TY - JOUR AB - We characterize critical points of 1-dimensional maps paired in persistent homology geometrically and this way get elementary proofs of theorems about the symmetry of persistence diagrams and the variation of such maps. In particular, we identify branching points and endpoints of networks as the sole source of asymmetry and relate the cycle basis in persistent homology with a version of the stable marriage problem. Our analysis provides the foundations of fast algorithms for maintaining collections of interrelated sorted lists together with their persistence diagrams. AU - Biswas, Ranita AU - Cultrera di Montesano, Sebastiano AU - Edelsbrunner, Herbert AU - Saghafian, Morteza ID - 11660 JF - LIPIcs TI - A window to the persistence of 1D maps. I: Geometric characterization of critical point pairs ER - TY - JOUR AB - The depth of a cell in an arrangement of n (non-vertical) great-spheres in Sd is the number of great-spheres that pass above the cell. We prove Euler-type relations, which imply extensions of the classic Dehn–Sommerville relations for convex polytopes to sublevel sets of the depth function, and we use the relations to extend the expressions for the number of faces of neighborly polytopes to the number of cells of levels in neighborly arrangements. AU - Biswas, Ranita AU - Cultrera di Montesano, Sebastiano AU - Edelsbrunner, Herbert AU - Saghafian, Morteza ID - 11658 JF - Leibniz International Proceedings on Mathematics TI - Depth in arrangements: Dehn–Sommerville–Euler relations with applications ER - TY - GEN AB - Given a locally finite set A⊆Rd and a coloring χ:A→{0,1,…,s}, we introduce the chromatic Delaunay mosaic of χ, which is a Delaunay mosaic in Rs+d that represents how points of different colors mingle. Our main results are bounds on the size of the chromatic Delaunay mosaic, in which we assume that d and s are constants. For example, if A is finite with n=#A, and the coloring is random, then the chromatic Delaunay mosaic has O(n⌈d/2⌉) cells in expectation. In contrast, for Delone sets and Poisson point processes in Rd, the expected number of cells within a closed ball is only a constant times the number of points in this ball. Furthermore, in R2 all colorings of a dense set of n points have chromatic Delaunay mosaics of size O(n). This encourages the use of chromatic Delaunay mosaics in applications. AU - Biswas, Ranita AU - Cultrera di Montesano, Sebastiano AU - Draganov, Ondrej AU - Edelsbrunner, Herbert AU - Saghafian, Morteza ID - 15090 T2 - arXiv TI - On the size of chromatic Delaunay mosaics ER - TY - JOUR AB - It is practical to collect a huge amount of movement data and environmental context information along with the health signals of individuals because there is the emergence of new generations of positioning and tracking technologies and rapid advancements of health sensors. The study of the relations between these datasets and their sequence similarity analysis is of interest to many applications such as health monitoring and recommender systems. However, entering all movement parameters and health signals can lead to the complexity of the problem and an increase in its computational load. In this situation, dimension reduction techniques can be used to avoid consideration of simultaneous dependent parameters in the process of similarity measurement of the trajectories. The present study provides a framework, named CaDRAW, to use spatial–temporal data and movement parameters along with independent context information in the process of measuring the similarity of trajectories. In this regard, the omission of dependent movement characteristic signals is conducted by using an unsupervised feature selection dimension reduction technique. To evaluate the effectiveness of the proposed framework, it was applied to a real contextualized movement and related health signal datasets of individuals. The results indicated the capability of the proposed framework in measuring the similarity and in decreasing the characteristic signals in such a way that the similarity results -before and after reduction of dependent characteristic signals- have small differences. The mean differences between the obtained results before and after reducing the dimension were 0.029 and 0.023 for the round path, respectively. AU - Goudarzi, Samira AU - Sharif, Mohammad AU - Karimipour, Farid ID - 10208 JF - Journal of Ambient Intelligence and Humanized Computing KW - general computer science SN - 1868-5137 TI - A context-aware dimension reduction framework for trajectory and health signal analyses VL - 13 ER -