--- _id: '10896' abstract: - lang: eng text: Under physiological conditions the brain, via the purine salvage pathway, reuses the preformed purine bases hypoxanthine, derived from ATP degradation, and adenine (Ade), derived from polyamine synthesis, to restore its ATP pool. However, the massive degradation of ATP during ischemia, although providing valuable neuroprotective adenosine, results in the accumulation and loss of diffusible purine metabolites and thereby leads to a protracted reduction in the post-ischemic ATP pool size. In vivo, this may both limit the ability to deploy ATP-dependent reparative mechanisms and reduce the subsequent availability of adenosine, whilst in brain slices results in tissue with substantially lower levels of ATP than in vivo. In the present review, we describe the mechanisms by which brain tissue replenishes its ATP, how this can be improved with the clinically tolerated chemicals D-ribose and adenine, and the functional, and potential therapeutic, implications of doing so. acknowledgement: We are grateful to Research into Ageing/Ageing UK and The Dunhill Trust for funding SzN’s graduate studies, and to Prof Nicholas Dale for his valuable input. article_processing_charge: No author: - first_name: Stephanie full_name: zur Nedden, Stephanie id: 3C77F464-F248-11E8-B48F-1D18A9856A87 last_name: zur Nedden - first_name: Alexander S. full_name: Doney, Alexander S. last_name: Doney - first_name: Bruno G. full_name: Frenguelli, Bruno G. last_name: Frenguelli citation: ama: 'zur Nedden S, Doney AS, Frenguelli BG. The double-edged sword: Gaining Adenosine at the expense of ATP. How to balance the books. In: Masino S, Boison D, eds. Adenosine. 1st ed. New York: Springer; 2012:109-129. doi:10.1007/978-1-4614-3903-5_6' apa: 'zur Nedden, S., Doney, A. S., & Frenguelli, B. G. (2012). The double-edged sword: Gaining Adenosine at the expense of ATP. How to balance the books. In S. Masino & D. Boison (Eds.), Adenosine (1st ed., pp. 109–129). New York: Springer. https://doi.org/10.1007/978-1-4614-3903-5_6' chicago: 'Nedden, Stephanie zur, Alexander S. Doney, and Bruno G. Frenguelli. “The Double-Edged Sword: Gaining Adenosine at the Expense of ATP. How to Balance the Books.” In Adenosine, edited by Susan Masino and Detlev Boison, 1st ed., 109–29. New York: Springer, 2012. https://doi.org/10.1007/978-1-4614-3903-5_6.' ieee: 'S. zur Nedden, A. S. Doney, and B. G. Frenguelli, “The double-edged sword: Gaining Adenosine at the expense of ATP. How to balance the books,” in Adenosine, 1st ed., S. Masino and D. Boison, Eds. New York: Springer, 2012, pp. 109–129.' ista: 'zur Nedden S, Doney AS, Frenguelli BG. 2012.The double-edged sword: Gaining Adenosine at the expense of ATP. How to balance the books. In: Adenosine. , 109–129.' mla: 'zur Nedden, Stephanie, et al. “The Double-Edged Sword: Gaining Adenosine at the Expense of ATP. How to Balance the Books.” Adenosine, edited by Susan Masino and Detlev Boison, 1st ed., Springer, 2012, pp. 109–29, doi:10.1007/978-1-4614-3903-5_6.' short: S. zur Nedden, A.S. Doney, B.G. Frenguelli, in:, S. Masino, D. Boison (Eds.), Adenosine, 1st ed., Springer, New York, 2012, pp. 109–129. date_created: 2022-03-21T07:16:12Z date_published: 2012-07-23T00:00:00Z date_updated: 2022-06-21T11:51:58Z day: '23' department: - _id: HaJa doi: 10.1007/978-1-4614-3903-5_6 edition: '1' editor: - first_name: Susan full_name: Masino, Susan last_name: Masino - first_name: Detlev full_name: Boison, Detlev last_name: Boison language: - iso: eng month: '07' oa_version: None page: 109-129 place: New York publication: Adenosine publication_identifier: eisbn: - '9781461439035' isbn: - '9781461439028' publication_status: published publisher: Springer quality_controlled: '1' scopus_import: '1' status: public title: 'The double-edged sword: Gaining Adenosine at the expense of ATP. How to balance the books' type: book_chapter user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87 year: '2012' ... --- _id: '3405' abstract: - lang: eng text: Glutamate is the major excitatory neurotransmitter in the mammalian central nervous system and gates non-selective cation channels. The origins of glutamate receptors are not well understood as they differ structurally and functionally from simple bacterial ligand-gated ion channels. Here we report the discovery of an ionotropic glutamate receptor that combines the typical eukaryotic domain architecture with the 'TXVGYG' signature sequence of the selectivity filter found in K+ channels. This receptor exhibits functional properties intermediate between bacterial and eukaryotic glutamate-gated ion channels, suggesting a link in the evolution of ionotropic glutamate receptors. author: - first_name: Harald L full_name: Janovjak, Harald L id: 33BA6C30-F248-11E8-B48F-1D18A9856A87 last_name: Janovjak orcid: 0000-0002-8023-9315 - first_name: Guillaume full_name: Sandoz, Guillaume last_name: Sandoz - first_name: Ehud full_name: Isacoff, Ehud last_name: Isacoff citation: ama: Janovjak HL, Sandoz G, Isacoff E. Modern ionotropic glutamate receptor with a K+ selectivity signature sequence. Nature Communications. 2011;2(232):1-6. doi:10.1038/ncomms1231 apa: Janovjak, H. L., Sandoz, G., & Isacoff, E. (2011). Modern ionotropic glutamate receptor with a K+ selectivity signature sequence. Nature Communications. Nature Publishing Group. https://doi.org/10.1038/ncomms1231 chicago: Janovjak, Harald L, Guillaume Sandoz, and Ehud Isacoff. “Modern Ionotropic Glutamate Receptor with a K+ Selectivity Signature Sequence.” Nature Communications. Nature Publishing Group, 2011. https://doi.org/10.1038/ncomms1231. ieee: H. L. Janovjak, G. Sandoz, and E. Isacoff, “Modern ionotropic glutamate receptor with a K+ selectivity signature sequence,” Nature Communications, vol. 2, no. 232. Nature Publishing Group, pp. 1–6, 2011. ista: Janovjak HL, Sandoz G, Isacoff E. 2011. Modern ionotropic glutamate receptor with a K+ selectivity signature sequence. Nature Communications. 2(232), 1–6. mla: Janovjak, Harald L., et al. “Modern Ionotropic Glutamate Receptor with a K+ Selectivity Signature Sequence.” Nature Communications, vol. 2, no. 232, Nature Publishing Group, 2011, pp. 1–6, doi:10.1038/ncomms1231. short: H.L. Janovjak, G. Sandoz, E. Isacoff, Nature Communications 2 (2011) 1–6. date_created: 2018-12-11T12:03:09Z date_published: 2011-03-08T00:00:00Z date_updated: 2021-01-12T07:43:15Z day: '08' ddc: - '570' - '571' department: - _id: HaJa doi: 10.1038/ncomms1231 file: - access_level: open_access checksum: 6b68d65aadd97c18d663eb117a0a9d35 content_type: application/pdf creator: system date_created: 2018-12-12T10:11:36Z date_updated: 2020-07-14T12:46:12Z file_id: '4891' file_name: IST-2017-832-v1+1_janovjak.pdf file_size: 387654 relation: main_file file_date_updated: 2020-07-14T12:46:12Z has_accepted_license: '1' intvolume: ' 2' issue: '232' language: - iso: eng month: '03' oa: 1 oa_version: Submitted Version page: 1 - 6 publication: Nature Communications publication_status: published publisher: Nature Publishing Group publist_id: '2997' pubrep_id: '832' quality_controlled: '1' scopus_import: 1 status: public title: Modern ionotropic glutamate receptor with a K+ selectivity signature sequence type: journal_article user_id: 4435EBFC-F248-11E8-B48F-1D18A9856A87 volume: 2 year: '2011' ...