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89 Publications
2020 | Journal Article | IST-REx-ID: 7569 | 
The relation between crosstalk and gene regulation form revisited
R. Grah, T. Friedlander, PLOS Computational Biology 16 (2020).
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R. Grah, T. Friedlander, PLOS Computational Biology 16 (2020).
2020 | Thesis | IST-REx-ID: 7680
Synthetic tools for optogenetic and chemogenetic inhibition of cellular signals
S. Kainrath, Synthetic Tools for Optogenetic and Chemogenetic Inhibition of Cellular Signals, IST Austria, 2020.
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S. Kainrath, Synthetic Tools for Optogenetic and Chemogenetic Inhibition of Cellular Signals, IST Austria, 2020.
2020 | Book Chapter | IST-REx-ID: 8173
Design and application of light-regulated receptor tyrosine kinases
S. Kainrath, H.L. Janovjak, in:, D. Niopek (Ed.), Photoswitching Proteins, Springer Nature, 2020, pp. 233–246.
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S. Kainrath, H.L. Janovjak, in:, D. Niopek (Ed.), Photoswitching Proteins, Springer Nature, 2020, pp. 233–246.
2020 | Preprint | IST-REx-ID: 7675 |
Normative models of enhancer function
R. Grah, B. Zoller, G. Tkačik, BioRxiv (2020).
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R. Grah, B. Zoller, G. Tkačik, BioRxiv (2020).
2020 | Journal Article | IST-REx-ID: 7652 |
Gene amplification as a form of population-level gene expression regulation
I. Tomanek, R. Grah, M. Lagator, A.M.C. Andersson, J.P. Bollback, G. Tkačik, C.C. Guet, Nature Ecology & Evolution 4 (2020) 612–625.
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I. Tomanek, R. Grah, M. Lagator, A.M.C. Andersson, J.P. Bollback, G. Tkačik, C.C. Guet, Nature Ecology & Evolution 4 (2020) 612–625.
2020 | Thesis | IST-REx-ID: 8155 |
Gene regulation across scales – how biophysical constraints shape evolution
R. Grah, Gene Regulation across Scales – How Biophysical Constraints Shape Evolution, IST Austria, 2020.
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R. Grah, Gene Regulation across Scales – How Biophysical Constraints Shape Evolution, IST Austria, 2020.
2020 | Thesis | IST-REx-ID: 8653
The evolution of gene expression by copy number and point mutations
I. Tomanek, The Evolution of Gene Expression by Copy Number and Point Mutations, IST Austria, 2020.
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I. Tomanek, The Evolution of Gene Expression by Copy Number and Point Mutations, IST Austria, 2020.
2020 | Research Data | IST-REx-ID: 7383 |
Matlab scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression regulation
R. Grah, Matlab Scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression Regulation, IST Austria, 2020.
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R. Grah, Matlab Scripts for the Paper: Gene Amplification as a Form of Population-Level Gene Expression Regulation, IST Austria, 2020.
2019 | Conference Paper | IST-REx-ID: 7147
Transient memory in gene regulation
C.C. Guet, T.A. Henzinger, C. Igler, T. Petrov, A. Sezgin, in:, 17th International Conference on Computational Methods in Systems Biology, Springer Nature, 2019, pp. 155–187.
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C.C. Guet, T.A. Henzinger, C. Igler, T. Petrov, A. Sezgin, in:, 17th International Conference on Computational Methods in Systems Biology, Springer Nature, 2019, pp. 155–187.
2019 | Thesis | IST-REx-ID: 6371 |
On the nature of gene regulatory design - The biophysics of transcription factor binding shapes gene regulation
C. Igler, On the Nature of Gene Regulatory Design - The Biophysics of Transcription Factor Binding Shapes Gene Regulation, IST Austria, 2019.
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C. Igler, On the Nature of Gene Regulatory Design - The Biophysics of Transcription Factor Binding Shapes Gene Regulation, IST Austria, 2019.
2019 | Journal Article | IST-REx-ID: 6465 |
A modular degron library for synthetic circuits in mammalian cells
H. Chassin, M. Müller, M. Tigges, L. Scheller, M. Lang, M. Fussenegger, Nature Communications 10 (2019).
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H. Chassin, M. Müller, M. Tigges, L. Scheller, M. Lang, M. Fussenegger, Nature Communications 10 (2019).
2019 | Journal Article | IST-REx-ID: 6717 |
Commentary: A host-produced quorum-sensing autoinducer controls a phage lysis-lysogeny decision
C. Igler, S.T. Abedon, Frontiers in Microbiology 10 (2019).
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C. Igler, S.T. Abedon, Frontiers in Microbiology 10 (2019).
2019 | Journal Article | IST-REx-ID: 6784 |
Molecular noise of innate immunity shapes bacteria-phage ecologies
J. Ruess, M. Pleska, C.C. Guet, G. Tkačik, PLoS Computational Biology 15 (2019).
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J. Ruess, M. Pleska, C.C. Guet, G. Tkačik, PLoS Computational Biology 15 (2019).
2019 | Journal Article | IST-REx-ID: 196 |
Harmonic dynamics of the Abelian sandpile
M. Lang, M. Shkolnikov, Proceedings of the National Academy of Sciences 116 (2019) 2821–2830.
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M. Lang, M. Shkolnikov, Proceedings of the National Academy of Sciences 116 (2019) 2821–2830.
2019 | Journal Article | IST-REx-ID: 138 |
Autoregulation of bacterial gene expression: lessons from the MazEF toxin–antitoxin system
N. Nikolic, Current Genetics 65 (2019) 133–138.
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N. Nikolic, Current Genetics 65 (2019) 133–138.
2019 | Research Data | IST-REx-ID: 7016 |
Data for the paper "Gene amplification as a form of population-level gene expression regulation"
I. Tomanek, Data for the Paper “Gene Amplification as a Form of Population-Level Gene Expression Regulation,” IST Austria, 2019.
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I. Tomanek, Data for the Paper “Gene Amplification as a Form of Population-Level Gene Expression Regulation,” IST Austria, 2019.
2018 | Thesis | IST-REx-ID: 26 |
The influence of sequence context on the evolution of bacterial gene expression
M. Steinrück, The Influence of Sequence Context on the Evolution of Bacterial Gene Expression, IST Austria, 2018.
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M. Steinrück, The Influence of Sequence Context on the Evolution of Bacterial Gene Expression, IST Austria, 2018.
2018 | Journal Article | IST-REx-ID: 723 |
How to escape local optima in black box optimisation when non elitism outperforms elitism
P. Oliveto, T. Paixao, J. Pérez Heredia, D. Sudholt, B. Trubenova, Algorithmica 80 (2018) 1604–1633.
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P. Oliveto, T. Paixao, J. Pérez Heredia, D. Sudholt, B. Trubenova, Algorithmica 80 (2018) 1604–1633.
2018 | Journal Article | IST-REx-ID: 438 |
Autoregulation of mazEF expression underlies growth heterogeneity in bacterial populations
N. Nikolic, T. Bergmiller, A. Vandervelde, T. Albanese, L. Gelens, I. Moll, Nucleic Acids Research 46 (2018) 2918–2931.
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N. Nikolic, T. Bergmiller, A. Vandervelde, T. Albanese, L. Gelens, I. Moll, Nucleic Acids Research 46 (2018) 2918–2931.
2018 | Journal Article | IST-REx-ID: 457
Phage-host population dynamics promotes prophage acquisition in bacteria with innate immunity
M. Pleska, M. Lang, D. Refardt, B. Levin, C.C. Guet, Nature Ecology and Evolution 2 (2018) 359–366.
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M. Pleska, M. Lang, D. Refardt, B. Levin, C.C. Guet, Nature Ecology and Evolution 2 (2018) 359–366.
2018 | Journal Article | IST-REx-ID: 503
Lack of cations in flow cytometry buffers affect fluorescence signals by reducing membrane stability and viability of Escherichia coli strains
K. Tomasek, T. Bergmiller, C.C. Guet, Journal of Biotechnology 268 (2018) 40–52.
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K. Tomasek, T. Bergmiller, C.C. Guet, Journal of Biotechnology 268 (2018) 40–52.
2018 | Research Data | IST-REx-ID: 5569 |
Time-lapse microscopy data
T. Bergmiller, N. Nikolic, Time-Lapse Microscopy Data, IST Austria, 2018.
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T. Bergmiller, N. Nikolic, Time-Lapse Microscopy Data, IST Austria, 2018.
2018 | Research Data | IST-REx-ID: 5585 |
Data for the paper Evolutionary potential of transcription factors for gene regulatory rewiring
C. Igler, M. Lagator, G. Tkačik, J.P. Bollback, C.C. Guet, Data for the Paper Evolutionary Potential of Transcription Factors for Gene Regulatory Rewiring, IST Austria, 2018.
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C. Igler, M. Lagator, G. Tkačik, J.P. Bollback, C.C. Guet, Data for the Paper Evolutionary Potential of Transcription Factors for Gene Regulatory Rewiring, IST Austria, 2018.
2018 | Journal Article | IST-REx-ID: 5984 |
Optical functionalization of human class A orphan G-protein-coupled receptors
M. Morri, I. Sanchez-Romero, A.-M. Tichy, S. Kainrath, E.J. Gerrard, P. Hirschfeld, J. Schwarz, H.L. Janovjak, Nature Communications 9 (2018).
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M. Morri, I. Sanchez-Romero, A.-M. Tichy, S. Kainrath, E.J. Gerrard, P. Hirschfeld, J. Schwarz, H.L. Janovjak, Nature Communications 9 (2018).
2018 | Journal Article | IST-REx-ID: 305
Fabrication and operation of microfluidic hanging drop networks
P. Misun, A. Birchler, M. Lang, A. Hierlemann, O. Frey, Methods in Molecular Biology 1771 (2018) 183–202.
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P. Misun, A. Birchler, M. Lang, A. Hierlemann, O. Frey, Methods in Molecular Biology 1771 (2018) 183–202.
2018 | Journal Article | IST-REx-ID: 67 |
Evolutionary potential of transcription factors for gene regulatory rewiring
C. Igler, M. Lagator, G. Tkačik, J.P. Bollback, C.C. Guet, Nature Ecology and Evolution 2 (2018) 1633–1643.
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C. Igler, M. Lagator, G. Tkačik, J.P. Bollback, C.C. Guet, Nature Ecology and Evolution 2 (2018) 1633–1643.
2018 | Journal Article | IST-REx-ID: 161 |
Statistical mechanics for metabolic networks during steady state growth
D. De Martino, A.A. Mc, T. Bergmiller, C.C. Guet, G. Tkačik, Nature Communications 9 (2018).
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D. De Martino, A.A. Mc, T. Bergmiller, C.C. Guet, G. Tkačik, Nature Communications 9 (2018).
2018 | Journal Article | IST-REx-ID: 19 |
Nonoptimal gene expression creates latent potential for antibiotic resistance
A. Palmer, R.P. Chait, R. Kishony, Molecular Biology and Evolution 35 (2018) 2669–2684.
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| PubMed | Europe PMC
A. Palmer, R.P. Chait, R. Kishony, Molecular Biology and Evolution 35 (2018) 2669–2684.
2018 | Journal Article | IST-REx-ID: 82 |
Leaky resistance and the conditions for the existence of lytic bacteriophage
W. Chaudhry, M. Pleska, N. Shah, H. Weiss, I. Mccall, J. Meyer, A. Gupta, C.C. Guet, B. Levin, PLoS Biology 16 (2018).
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W. Chaudhry, M. Pleska, N. Shah, H. Weiss, I. Mccall, J. Meyer, A. Gupta, C.C. Guet, B. Levin, PLoS Biology 16 (2018).
2017 | Thesis | IST-REx-ID: 202 |
Biology of restriction-modification systems at the single-cell and population level
M. Pleska, Biology of Restriction-Modification Systems at the Single-Cell and Population Level, IST Austria, 2017.
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M. Pleska, Biology of Restriction-Modification Systems at the Single-Cell and Population Level, IST Austria, 2017.
2017 | Journal Article | IST-REx-ID: 735
An effective feedback loop between cell-cell contact duration and morphogen signaling determines cell fate
V. Barone, M. Lang, G. Krens, S. Pradhan, S. Shamipour, K. Sako, M.K. Sikora, C.C. Guet, C.-P.J. Heisenberg, Developmental Cell 43 (2017) 198–211.
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V. Barone, M. Lang, G. Krens, S. Pradhan, S. Shamipour, K. Sako, M.K. Sikora, C.C. Guet, C.-P.J. Heisenberg, Developmental Cell 43 (2017) 198–211.
2017 | Journal Article | IST-REx-ID: 538 |
Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen
S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie 129 (2017) 4679–4682.
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S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie 129 (2017) 4679–4682.
2017 | Journal Article | IST-REx-ID: 541 |
Cell-to-cell variation and specialization in sugar metabolism in clonal bacterial populations
N. Nikolic, F. Schreiber, A. Dal Co, D. Kiviet, T. Bergmiller, S. Littmann, M. Kuypers, M. Ackermann, PLoS Genetics 13 (2017).
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N. Nikolic, F. Schreiber, A. Dal Co, D. Kiviet, T. Bergmiller, S. Littmann, M. Kuypers, M. Ackermann, PLoS Genetics 13 (2017).
2017 | Research Data | IST-REx-ID: 5560 |
Biased partitioning of the multi-drug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity
T. Bergmiller, A.M. Andersson, K. Tomasek, E. Balleza, D. Kiviet, R. Hauschild, G. Tkačik, C.C. Guet, Biased Partitioning of the Multi-Drug Efflux Pump AcrAB-TolC Underlies Long-Lived Phenotypic Heterogeneity, IST Austria, 2017.
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T. Bergmiller, A.M. Andersson, K. Tomasek, E. Balleza, D. Kiviet, R. Hauschild, G. Tkačik, C.C. Guet, Biased Partitioning of the Multi-Drug Efflux Pump AcrAB-TolC Underlies Long-Lived Phenotypic Heterogeneity, IST Austria, 2017.
2017 | Research Data | IST-REx-ID: 5564 |
Fastq files for "Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection"
M. Steinrück, C.C. Guet, Fastq Files for “Complex Chromosomal Neighborhood Effects Determine the Adaptive Potential of a Gene under Selection,” IST Austria, 2017.
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M. Steinrück, C.C. Guet, Fastq Files for “Complex Chromosomal Neighborhood Effects Determine the Adaptive Potential of a Gene under Selection,” IST Austria, 2017.
2017 | Journal Article | IST-REx-ID: 561
Effects of mutations in phage restriction sites during escape from restriction–modification
M. Pleska, C.C. Guet, Biology Letters 13 (2017).
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M. Pleska, C.C. Guet, Biology Letters 13 (2017).
2017 | Journal Article | IST-REx-ID: 570 |
Regulatory network structure determines patterns of intermolecular epistasis
M. Lagator, S. Sarikas, H. Acar, J.P. Bollback, C.C. Guet, ELife 6 (2017).
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M. Lagator, S. Sarikas, H. Acar, J.P. Bollback, C.C. Guet, ELife 6 (2017).
2017 | Journal Article | IST-REx-ID: 613 |
Shaping bacterial population behavior through computer interfaced control of individual cells
R.P. Chait, J. Ruess, T. Bergmiller, G. Tkačik, C.C. Guet, Nature Communications 8 (2017).
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R.P. Chait, J. Ruess, T. Bergmiller, G. Tkačik, C.C. Guet, Nature Communications 8 (2017).
2017 | Journal Article | IST-REx-ID: 624 |
MazF activation promotes translational heterogeneity of the grcA mRNA in Escherichia coli populations
N. Nikolic, Z. Didara, I. Moll, PeerJ 2017 (2017).
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N. Nikolic, Z. Didara, I. Moll, PeerJ 2017 (2017).
2017 | Journal Article | IST-REx-ID: 655 |
Bacterial flagella grow through an injection diffusion mechanism
T. Renault, A. Abraham, T. Bergmiller, G. Paradis, S. Rainville, E. Charpentier, C.C. Guet, Y. Tu, K. Namba, J. Keener, T. Minamino, M. Erhardt, ELife 6 (2017).
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T. Renault, A. Abraham, T. Bergmiller, G. Paradis, S. Rainville, E. Charpentier, C.C. Guet, Y. Tu, K. Namba, J. Keener, T. Minamino, M. Erhardt, ELife 6 (2017).
2017 | Journal Article | IST-REx-ID: 665
Biased partitioning of the multidrug efflux pump AcrAB TolC underlies long lived phenotypic heterogeneity
T. Bergmiller, A.M. Andersson, K. Tomasek, E. Balleza, D. Kiviet, R. Hauschild, G. Tkacik, C.C. Guet, Science 356 (2017) 311–315.
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T. Bergmiller, A.M. Andersson, K. Tomasek, E. Balleza, D. Kiviet, R. Hauschild, G. Tkacik, C.C. Guet, Science 356 (2017) 311–315.
2017 | Journal Article | IST-REx-ID: 696 |
Stress induced mutagenesis: Stress diversity facilitates the persistence of mutator genes
M. Lukacisinova, S. Novak, T. Paixao, PLoS Computational Biology 13 (2017).
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M. Lukacisinova, S. Novak, T. Paixao, PLoS Computational Biology 13 (2017).
2017 | Journal Article | IST-REx-ID: 704 |
Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection
M. Steinrück, C.C. Guet, ELife 6 (2017).
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M. Steinrück, C.C. Guet, ELife 6 (2017).
2017 | Journal Article | IST-REx-ID: 954 |
On the mechanistic nature of epistasis in a canonical cis-regulatory element
M. Lagator, T. Paixao, N.H. Barton, J.P. Bollback, C.C. Guet, ELife 6 (2017).
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M. Lagator, T. Paixao, N.H. Barton, J.P. Bollback, C.C. Guet, ELife 6 (2017).
2017 | Journal Article | IST-REx-ID: 1336 |
Towards a runtime comparison of natural and artificial evolution
T. Paixao, J. Pérez Heredia, D. Sudholt, B. Trubenova, Algorithmica 78 (2017) 681–713.
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T. Paixao, J. Pérez Heredia, D. Sudholt, B. Trubenova, Algorithmica 78 (2017) 681–713.
2017 | Journal Article | IST-REx-ID: 1351 |
Model checking the evolution of gene regulatory networks
M. Giacobbe, C.C. Guet, A. Gupta, T.A. Henzinger, T. Paixao, T. Petrov, Acta Informatica 54 (2017) 765–787.
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M. Giacobbe, C.C. Guet, A. Gupta, T.A. Henzinger, T. Paixao, T. Petrov, Acta Informatica 54 (2017) 765–787.
2017 | Journal Article | IST-REx-ID: 1007 |
Zeros of nonlinear systems with input invariances
M. Lang, E. Sontag, Automatica 81C (2017) 46–55.
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M. Lang, E. Sontag, Automatica 81C (2017) 46–55.
2017 | Journal Article | IST-REx-ID: 1028 |
Green-light-induced inactivation of receptor signaling using cobalamin-binding domains
S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie - International Edition 56 (2017) 4608–4611.
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S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie - International Edition 56 (2017) 4608–4611.
2017 | Journal Article | IST-REx-ID: 1084
Insulation and wiring specificity of BceR like response regulators and their target promoters in Bacillus subtilis
C. Fang, A.A. Nagy-Staron, M. Grafe, R. Heermann, K. Jung, S. Gebhard, T. Mascher, Molecular Microbiology 104 (2017) 16–31.
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C. Fang, A.A. Nagy-Staron, M. Grafe, R. Heermann, K. Jung, S. Gebhard, T. Mascher, Molecular Microbiology 104 (2017) 16–31.
2016 | Conference Paper | IST-REx-ID: 1220 |
Fuselage boundary layer ingestion propulsion applied to a thin haul commuter aircraft for optimal efficiency
G. Mikić, A. Stoll, J. Bevirt, R. Grah, M. Moore, in:, AIAA, 2016, pp. 1–19.
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G. Mikić, A. Stoll, J. Bevirt, R. Grah, M. Moore, in:, AIAA, 2016, pp. 1–19.