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88 Publications

2017 | Journal Article | IST-REx-ID: 696 | OA
M. Lukacisinova, S. Novak, and T. Paixao, “Stress induced mutagenesis: Stress diversity facilitates the persistence of mutator genes,” PLoS Computational Biology, vol. 13, no. 7, 2017.
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2017 | Journal Article | IST-REx-ID: 704 | OA
M. Steinrück and C. C. Guet, “Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection,” eLife, vol. 6, 2017.
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2017 | Journal Article | IST-REx-ID: 954 | OA
M. Lagator, T. Paixao, N. H. Barton, J. P. Bollback, and C. C. Guet, “On the mechanistic nature of epistasis in a canonical cis-regulatory element,” eLife, vol. 6, 2017.
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2017 | Journal Article | IST-REx-ID: 1336 | OA
T. Paixao, J. Pérez Heredia, D. Sudholt, and B. Trubenova, “Towards a runtime comparison of natural and artificial evolution,” Algorithmica, vol. 78, no. 2, pp. 681–713, 2017.
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2017 | Journal Article | IST-REx-ID: 1351 | OA
M. Giacobbe, C. C. Guet, A. Gupta, T. A. Henzinger, T. Paixao, and T. Petrov, “Model checking the evolution of gene regulatory networks,” Acta Informatica, vol. 54, no. 8, pp. 765–787, 2017.
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2017 | Journal Article | IST-REx-ID: 1007 | OA
M. Lang and E. Sontag, “Zeros of nonlinear systems with input invariances,” Automatica, vol. 81C, pp. 46–55, 2017.
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2017 | Journal Article | IST-REx-ID: 1028 | OA
S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, and H. L. Janovjak, “Green-light-induced inactivation of receptor signaling using cobalamin-binding domains,” Angewandte Chemie - International Edition, vol. 56, no. 16, pp. 4608–4611, 2017.
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2017 | Journal Article | IST-REx-ID: 1084
C. Fang et al., “Insulation and wiring specificity of BceR like response regulators and their target promoters in Bacillus subtilis,” Molecular Microbiology, vol. 104, no. 1, pp. 16–31, 2017.
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2016 | Conference Paper | IST-REx-ID: 1220 | OA
G. Mikić, A. Stoll, J. Bevirt, R. Grah, and M. Moore, “Fuselage boundary layer ingestion propulsion applied to a thin haul commuter aircraft for optimal efficiency,” presented at the AIAA: Aviation Technology, Integration, and Operations Conference, Washington, D.C., USA, 2016, pp. 1–19.
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2016 | Conference Paper | IST-REx-ID: 1234 | OA
P. Daca, T. A. Henzinger, J. Kretinsky, and T. Petrov, “Faster statistical model checking for unbounded temporal properties,” presented at the TACAS: Tools and Algorithms for the Construction and Analysis of Systems, Eindhoven, The Netherlands, 2016, vol. 9636, pp. 112–129.
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2016 | Journal Article | IST-REx-ID: 1243
M. Pleska et al., “Bacterial autoimmunity due to a restriction-modification system,” Current Biology, vol. 26, no. 3, pp. 404–409, 2016.
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2016 | Journal Article | IST-REx-ID: 1250 | OA
A. Boehm, M. Arnoldini, T. Bergmiller, T. Röösli, C. Bigosch, and M. Ackermann, “Genetic manipulation of glycogen allocation affects replicative lifespan in E coli,” PLoS Genetics, vol. 12, no. 4, 2016.
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2016 | Journal Article | IST-REx-ID: 1290 | OA
L. Stone, M. Baym, T. Lieberman, R. P. Chait, J. Clardy, and R. Kishony, “Compounds that select against the tetracycline-resistance efflux pump,” Nature Chemical Biology, vol. 12, no. 11, pp. 902–904, 2016.
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2016 | Conference Paper | IST-REx-ID: 1320
M. Lang and E. Sontag, “Scale-invariant systems realize nonlinear differential operators,” presented at the ACC: American Control Conference, Boston, MA, USA, 2016, vol. 2016–July.
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2016 | Journal Article | IST-REx-ID: 1332 | OA
R. P. Chait, A. Palmer, I. Yelin, and R. Kishony, “Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments,” Nature Communications, vol. 7, 2016.
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2016 | Journal Article | IST-REx-ID: 1342 | OA
M. Baym et al., “Spatiotemporal microbial evolution on antibiotic landscapes,” Science, vol. 353, no. 6304, pp. 1147–1151, 2016.
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2016 | Conference Paper | IST-REx-ID: 1349 | OA
P. Oliveto, T. Paixao, J. Heredia, D. Sudholt, and B. Trubenova, “When non-elitism outperforms elitism for crossing fitness valleys,” in Proceedings of the Genetic and Evolutionary Computation Conference 2016 , Denver, CO, USA, 2016, pp. 1163–1170.
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2016 | Journal Article | IST-REx-ID: 1358 | OA
T. Friedlander, R. Prizak, C. C. Guet, N. H. Barton, and G. Tkačik, “Intrinsic limits to gene regulation by global crosstalk,” Nature Communications, vol. 7, 2016.
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2016 | Journal Article | IST-REx-ID: 1359 | OA
T. Paixao and N. H. Barton, “The effect of gene interactions on the long-term response to selection,” PNAS, vol. 113, no. 16, pp. 4422–4427, 2016.
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2016 | Journal Article | IST-REx-ID: 1427 | OA
M. Lagator, C. Igler, A. Moreno, C. C. Guet, and J. P. Bollback, “Epistatic interactions in the arabinose cis-regulatory element,” Molecular Biology and Evolution, vol. 33, no. 3, pp. 761–769, 2016.
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2016 | Conference Paper | IST-REx-ID: 1524 | OA
A. Beica, C. C. Guet, and T. Petrov, “Efficient reduction of kappa models by static inspection of the rule-set,” presented at the HSB: Hybrid Systems Biology, Madrid, Spain, 2016, vol. 9271, pp. 173–191.
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2016 | Journal Article | IST-REx-ID: 1008
R. Gnügge, L. Dharmarajan, M. Lang, and J. Stelling, “An orthogonal permease–inducer–repressor feedback loop shows bistability,” ACS Synthetic Biology, vol. 5, no. 10, pp. 1098–1107, 2016.
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2016 | Conference Paper | IST-REx-ID: 1093 | OA
P. Daca, T. A. Henzinger, J. Kretinsky, and T. Petrov, “Linear distances between Markov chains,” presented at the CONCUR: Concurrency Theory, Quebec City; Canada, 2016, vol. 59.
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2016 | Journal Article | IST-REx-ID: 1170
M. Lang and J. Stelling, “Modular parameter identification of biomolecular networks,” SIAM Journal on Scientific Computing, vol. 38, no. 6, pp. B988–B1008, 2016.
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2015 | Journal Article | IST-REx-ID: 5749 | OA
S. Wielgoss, T. Bergmiller, A. M. Bischofberger, and A. R. Hall, “Adaptation to Parasites and Costs of Parasite Resistance in Mutator and Nonmutator Bacteria,” Molecular Biology and Evolution, vol. 33, no. 3, pp. 770–782, 2015.
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2015 | Journal Article | IST-REx-ID: 1542 | OA
T. Paixao et al., “Toward a unifying framework for evolutionary processes,” Journal of Theoretical Biology, vol. 383, pp. 28–43, 2015.
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2015 | Journal Article | IST-REx-ID: 1666 | OA
M. Tugrul, T. Paixao, N. H. Barton, and G. Tkačik, “Dynamics of transcription factor binding site evolution,” PLoS Genetics, vol. 11, no. 11, 2015.
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2015 | Conference Paper | IST-REx-ID: 1835 | OA
M. Giacobbe, C. C. Guet, A. Gupta, T. A. Henzinger, T. Paixao, and T. Petrov, “Model checking gene regulatory networks,” vol. 9035. Springer, pp. 469–483, 2015.
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2015 | Journal Article | IST-REx-ID: 1840 | OA
B. Geiger, T. Petrov, G. Kubin, and H. Koeppl, “Optimal Kullback-Leibler aggregation via information bottleneck,” IEEE Transactions on Automatic Control, vol. 60, no. 4, pp. 1010–1022, 2015.
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2015 | Conference Paper | IST-REx-ID: 1430 | OA
T. Paixao, D. Sudholt, J. Heredia, and B. Trubenova, “First steps towards a runtime comparison of natural and artificial evolution,” in Proceedings of the 2015 Annual Conference on Genetic and Evolutionary Computation, Madrid, Spain, 2015, pp. 1455–1462.
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2014 | Journal Article | IST-REx-ID: 2036 | OA
M. Lagator, N. Colegrave, and P. Neve, “Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses,” Proceedings of the Royal Society of London Series B Biological Sciences, vol. 281, no. 1794, 2014.
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2014 | Journal Article | IST-REx-ID: 2056 | OA
A. Ganguly, T. Petrov, and H. Koeppl, “Markov chain aggregation and its applications to combinatorial reaction networks,” Journal of Mathematical Biology, vol. 69, no. 3, pp. 767–797, 2014.
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2014 | Journal Article | IST-REx-ID: 2083 | OA
M. Lagator, A. Morgan, P. Neve, and N. Colegrave, “Role of sex and migration in adaptation to sink environments,” Evolution, vol. 68, no. 8, pp. 2296–2305, 2014.
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2014 | Journal Article | IST-REx-ID: 1894 | OA
A. Grabowska et al., “Functional and bioinformatics analysis of two Campylobacter jejuni homologs of the thiol-disulfide oxidoreductase, DsbA,” PLoS One, vol. 9, no. 9, 2014.
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2014 | Journal Article | IST-REx-ID: 1913 | OA
I. Milenković, T. Petrov, and G. Kovács, “Patterns of hippocampal tau pathology differentiate neurodegenerative dementias,” Dementia and Geriatric Cognitive Disorders, vol. 38, no. 5–6, pp. 375–388, 2014.
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2013 | Journal Article | IST-REx-ID: 499
Y. Wakamoto et al., “Dynamic persistence of antibiotic-stressed mycobacteria,” Science, vol. 339, no. 6115, pp. 91–95, 2013.
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2013 | Conference Paper | IST-REx-ID: 2718 | OA
N. H. Barton and T. Paixao, “Can quantitative and population genetics help us understand evolutionary computation?,” in Proceedings of the 15th annual conference on Genetic and evolutionary computation, Amsterdam, Netherlands, 2013, pp. 1573–1580.
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2013 | Conference Paper | IST-REx-ID: 2719
T. Paixao and N. H. Barton, “A variance decomposition approach to the analysis of genetic algorithms,” in Proceedings of the 15th annual conference on Genetic and evolutionary computation, Amsterdam, Netherlands, 2013, pp. 845–852.
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2013 | Journal Article | IST-REx-ID: 2720 | OA
H. Long, T. Paixao, R. Azevedo, and R. Zufall, “Accumulation of spontaneous mutations in the ciliate Tetrahymena thermophila,” Genetics, vol. 195, no. 2, pp. 527–540, 2013.
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2013 | Journal Article | IST-REx-ID: 2853 | OA
D. Refardt, T. Bergmiller, and R. Kümmerli, “Altruism can evolve when relatedness is low: Evidence from bacteria committing suicide upon phage infection,” Proceedings of the Royal Society of London Series B Biological Sciences, vol. 280, no. 1759, 2013.
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2012 | Journal Article | IST-REx-ID: 2302
T. A. Henzinger and M. Mateescu, “The propagation approach for computing biochemical reaction networks,” IEEE ACM Transactions on Computational Biology and Bioinformatics, vol. 10, no. 2, pp. 310–322, 2012.
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2012 | Journal Article | IST-REx-ID: 2943 | OA
N. Hadizadeh Yazdi, C. C. Guet, R. Johnson, and J. Marko, “Variation of the folding and dynamics of the Escherichia coli chromosome with growth conditions,” Molecular Microbiology, vol. 86, no. 6, pp. 1318–1333, 2012.
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2012 | Journal Article | IST-REx-ID: 3130 | OA
T. Bergmiller, M. Ackermann, and O. Silander, “Patterns of evolutionary conservation of essential genes correlate with their compensability,” PLoS Genetics, vol. 8, no. 6, 2012.
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2012 | Conference Paper | IST-REx-ID: 3136
C. C. Guet, A. Gupta, T. A. Henzinger, M. Mateescu, and A. Sezgin, “Delayed continuous time Markov chains for genetic regulatory circuits,” presented at the CAV: Computer Aided Verification, Berkeley, CA, USA, 2012, vol. 7358, pp. 294–309.
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2011 | Journal Article | IST-REx-ID: 6496 | OA
H. Park, P. Oikonomou, C. C. Guet, and P. Cluzel, “Noise underlies switching behavior of the bacterial flagellum,” Biophysical Journal, vol. 101, no. 10, pp. 2336–2340, 2011.
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2010 | Conference Paper | IST-REx-ID: 3719 | OA
J. Feret, T. A. Henzinger, H. Koeppl, and T. Petrov, “Lumpability abstractions of rule-based systems,” presented at the MECBIC: Membrane Computing and Biologically Inspired Process Calculi, Jena, Germany, 2010, vol. 40, pp. 142–161.
View | Files available | arXiv
 
2010 | Conference Paper | IST-REx-ID: 3847 | OA
F. Didier, T. A. Henzinger, M. Mateescu, and V. Wolf, “SABRE: A tool for the stochastic analysis of biochemical reaction networks,” presented at the QEST: Quantitative Evaluation of Systems, Williamsburg, USA, 2010, pp. 193–194.
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2009 | Conference Paper | IST-REx-ID: 3843 | OA
F. Didier, T. A. Henzinger, M. Mateescu, and V. Wolf, “Fast adaptive uniformization of the chemical master equation,” presented at the HIBI: High-Performance Computational Systems Biology, Trento, Italy, 2009, vol. 4, no. 6, pp. 118–127.
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