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79 Publications

2019 | Journal Article | IST-REx-ID: 6717   OA
C. Igler and S. T. Abedon, “Commentary: A host-produced quorum-sensing autoinducer controls a phage lysis-lysogeny decision,” Frontiers in Microbiology, vol. 10, p. 1171, 2019.
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2019 | Journal Article | IST-REx-ID: 6465   OA
H. Chassin, M. Müller, M. Tigges, L. Scheller, M. Lang, and M. Fussenegger, “A modular degron library for synthetic circuits in mammalian cells,” Nature Communications, vol. 10, no. 1, p. 2013, 2019.
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2019 | Thesis | IST-REx-ID: 6371
C. Igler, On the nature of gene regulatory design - The biophysics of transcription factor binding shapes gene regulation. IST Austria, 2019.
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2019 | Journal Article | IST-REx-ID: 138   OA
N. Nikolic, “Autoregulation of bacterial gene expression: lessons from the MazEF toxin–antitoxin system,” Current Genetics, vol. 65, no. 1, pp. 133–138, 2019.
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2019 | Journal Article | IST-REx-ID: 6784   OA
J. Ruess, M. Pleska, C. C. Guet, and G. Tkačik, “Molecular noise of innate immunity shapes bacteria-phage ecologies,” PLoS Computational Biology, vol. 15, no. 7, 2019.
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2018 | Journal Article | IST-REx-ID: 67
C. Igler, M. Lagator, G. Tkacik, J. P. Bollback, and C. C. Guet, “Evolutionary potential of transcription factors for gene regulatory rewiring,” Nature Ecology and Evolution, vol. 2, no. 10, pp. 1633–1643, 2018.
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2018 | Journal Article | IST-REx-ID: 82   OA
W. Chaudhry et al., “Leaky resistance and the conditions for the existence of lytic bacteriophage,” PLoS Biology, vol. 16, no. 8, 2018.
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2018 | Research Data | IST-REx-ID: 5569
T. Bergmiller and N. Nikolic, Time-lapse microscopy data. IST Austria, 2018.
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2018 | Journal Article | IST-REx-ID: 19   OA
A. Palmer, R. P. Chait, and R. Kishony, “Nonoptimal gene expression creates latent potential for antibiotic resistance,” Molecular Biology and Evolution, vol. 35, no. 11, pp. 2669–2684, 2018.
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2018 | Preprint | IST-REx-ID: 196   OA
M. Lang and M. Shkolnikov, “Harmonic dynamics of the Abelian sandpile,” ArXiv. ArXiv, 2018.
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2018 | Journal Article | IST-REx-ID: 305
P. Misun, A. Birchler, M. Lang, A. Hierlemann, and O. Frey, “Fabrication and operation of microfluidic hanging drop networks,” Methods in Molecular Biology, vol. 1771, pp. 183–202, 2018.
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2018 | Journal Article | IST-REx-ID: 723   OA
P. Oliveto, T. Paixao, J. Pérez Heredia, D. Sudholt, and B. Trubenova, “How to escape local optima in black box optimisation when non elitism outperforms elitism,” Algorithmica, vol. 80, no. 5, pp. 1604–1633, 2018.
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2018 | Thesis | IST-REx-ID: 26   OA
M. Steinrück, The influence of sequence context on the evolution of bacterial gene expression. IST Austria, 2018.
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2018 | Journal Article | IST-REx-ID: 503
K. Tomasek, T. Bergmiller, and C. C. Guet, “Lack of cations in flow cytometry buffers affect fluorescence signals by reducing membrane stability and viability of Escherichia coli strains,” Journal of Biotechnology, vol. 268, pp. 40–52, 2018.
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2018 | Journal Article | IST-REx-ID: 5984   OA
M. Morri et al., “Optical functionalization of human class A orphan G-protein-coupled receptors,” Nature Communications, vol. 9, no. 1, 2018.
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2018 | Research Data | IST-REx-ID: 5585
C. Igler, M. Lagator, G. Tkacik, J. P. Bollback, and C. C. Guet, Data for the paper Evolutionary potential of transcription factors for gene regulatory rewiring. IST Austria, 2018.
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2018 | Journal Article | IST-REx-ID: 438   OA
N. Nikolic, T. Bergmiller, A. Vandervelde, T. Albanese, L. Gelens, and I. Moll, “Autoregulation of mazEF expression underlies growth heterogeneity in bacterial populations,” Nucleic Acids Research, vol. 46, no. 6, pp. 2918–2931, 2018.
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2018 | Journal Article | IST-REx-ID: 161   OA
D. De Martino, A. A. Mc, T. Bergmiller, C. C. Guet, and G. Tkacik, “Statistical mechanics for metabolic networks during steady state growth,” Nature Communications, vol. 9, no. 1, p. 2988, 2018.
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2018 | Journal Article | IST-REx-ID: 457
M. Pleska, M. Lang, D. Refardt, B. Levin, and C. C. Guet, “Phage-host population dynamics promotes prophage acquisition in bacteria with innate immunity,” Nature Ecology and Evolution, vol. 2, no. 2, pp. 359–366, 2018.
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2017 | Journal Article | IST-REx-ID: 1084
C. Fang et al., “Insulation and wiring specificity of BceR like response regulators and their target promoters in Bacillus subtilis,” Molecular Microbiology, vol. 104, no. 1, pp. 16–31, 2017.
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2017 | Journal Article | IST-REx-ID: 624   OA
N. Nikolic, Z. Didara, and I. Moll, “MazF activation promotes translational heterogeneity of the grcA mRNA in Escherichia coli populations,” PeerJ, vol. 2017, no. 9, 2017.
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2017 | Journal Article | IST-REx-ID: 655   OA
T. Renault et al., “Bacterial flagella grow through an injection diffusion mechanism,” eLife, vol. 6, 2017.
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2017 | Journal Article | IST-REx-ID: 1351   OA
M. Giacobbe, C. C. Guet, A. Gupta, T. A. Henzinger, T. Paixao, and T. Petrov, “Model checking the evolution of gene regulatory networks,” Acta Informatica, vol. 54, no. 8, pp. 765–787, 2017.
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2017 | Journal Article | IST-REx-ID: 561
M. Pleska and C. C. Guet, “Effects of mutations in phage restriction sites during escape from restriction–modification,” Biology Letters, vol. 13, no. 12, 2017.
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2017 | Journal Article | IST-REx-ID: 613   OA
R. P. Chait, J. Ruess, T. Bergmiller, G. Tkacik, and C. C. Guet, “Shaping bacterial population behavior through computer interfaced control of individual cells,” Nature Communications, vol. 8, no. 1, 2017.
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2017 | Journal Article | IST-REx-ID: 954   OA
M. Lagator, T. Paixao, N. H. Barton, J. P. Bollback, and C. C. Guet, “On the mechanistic nature of epistasis in a canonical cis-regulatory element,” eLife, vol. 6, 2017.
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2017 | Journal Article | IST-REx-ID: 1028   OA
S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, and H. L. Janovjak, “Green-light-induced inactivation of receptor signaling using cobalamin-binding domains,” Angewandte Chemie - International Edition, vol. 56, no. 16, pp. 4608–4611, 2017.
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2017 | Thesis | IST-REx-ID: 202   OA
M. Pleska, Biology of restriction-modification systems at the single-cell and population level. IST Austria, 2017.
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2017 | Journal Article | IST-REx-ID: 570   OA
M. Lagator, S. Sarikas, H. Acar, J. P. Bollback, and C. C. Guet, “Regulatory network structure determines patterns of intermolecular epistasis,” eLife, vol. 6, 2017.
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2017 | Research Data | IST-REx-ID: 5564
M. Steinrück and C. C. Guet, Fastq files for “Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection.” IST Austria, 2017.
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2017 | Journal Article | IST-REx-ID: 538   OA
S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, and H. L. Janovjak, “Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen,” Angewandte Chemie, vol. 129, no. 16, pp. 4679–4682, 2017.
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2017 | Journal Article | IST-REx-ID: 665
T. Bergmiller et al., “Biased partitioning of the multidrug efflux pump AcrAB TolC underlies long lived phenotypic heterogeneity,” Science, vol. 356, no. 6335, pp. 311–315, 2017.
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2017 | Research Data | IST-REx-ID: 5560
T. Bergmiller et al., Biased partitioning of the multi-drug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity. IST Austria, 2017.
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2017 | Journal Article | IST-REx-ID: 735
V. Barone et al., “An effective feedback loop between cell-cell contact duration and morphogen signaling determines cell fate,” Developmental Cell, vol. 43, no. 2, pp. 198–211, 2017.
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2017 | Journal Article | IST-REx-ID: 696   OA
M. Lukacisinova, S. Novak, and T. Paixao, “Stress induced mutagenesis: Stress diversity facilitates the persistence of mutator genes,” PLoS Computational Biology, vol. 13, no. 7, p. e1005609, 2017.
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2017 | Journal Article | IST-REx-ID: 704
M. Steinrück and C. C. Guet, “Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection,” eLife, vol. 6, p. e25100, 2017.
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2017 | Journal Article | IST-REx-ID: 1007   OA
M. Lang and E. Sontag, “Zeros of nonlinear systems with input invariances,” Automatica, vol. 81C, pp. 46–55, 2017.
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2017 | Journal Article | IST-REx-ID: 1336   OA
T. Paixao, J. Pérez Heredia, D. Sudholt, and B. Trubenova, “Towards a runtime comparison of natural and artificial evolution,” Algorithmica, vol. 78, no. 2, pp. 681–713, 2017.
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2017 | Journal Article | IST-REx-ID: 541   OA
N. Nikolic et al., “Cell-to-cell variation and specialization in sugar metabolism in clonal bacterial populations,” PLoS Genetics, vol. 13, no. 12, 2017.
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2016 | Journal Article | IST-REx-ID: 1008
R. Gnügge, L. Dharmarajan, M. Lang, and J. Stelling, “An orthogonal permease–inducer–repressor feedback loop shows bistability,” ACS Synthetic Biology, vol. 5, no. 10, pp. 1098–1107, 2016.
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2016 | Journal Article | IST-REx-ID: 1250   OA
A. Boehm, M. Arnoldini, T. Bergmiller, T. Röösli, C. Bigosch, and M. Ackermann, “Genetic manipulation of glycogen allocation affects replicative lifespan in E coli,” PLoS Genetics, vol. 12, no. 4, 2016.
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2016 | Conference Paper | IST-REx-ID: 1320
M. Lang and E. Sontag, “Scale-invariant systems realize nonlinear differential operators,” presented at the ACC: American Control Conference, Boston, MA, USA, 2016, vol. 2016–July.
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2016 | Conference Paper | IST-REx-ID: 1349   OA
P. Oliveto, T. Paixao, J. Heredia, D. Sudholt, and B. Trubenova, “When non-elitism outperforms elitism for crossing fitness valleys,” in Proceedings of the Genetic and Evolutionary Computation Conference 2016 , Denver, CO, USA, 2016, pp. 1163–1170.
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2016 | Journal Article | IST-REx-ID: 1332   OA
R. P. Chait, A. Palmer, I. Yelin, and R. Kishony, “Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments,” Nature Communications, vol. 7, 2016.
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2016 | Journal Article | IST-REx-ID: 1243
M. Pleska et al., “Bacterial autoimmunity due to a restriction-modification system,” Current Biology, vol. 26, no. 3, pp. 404–409, 2016.
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2016 | Conference Paper | IST-REx-ID: 1220   OA
G. Mikić, A. Stoll, J. Bevirt, R. Grah, and M. Moore, “Fuselage boundary layer ingestion propulsion applied to a thin haul commuter aircraft for optimal efficiency,” presented at the AIAA: Aviation Technology, Integration, and Operations Conference, Washington, D.C., USA, 2016, pp. 1–19.
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2016 | Journal Article | IST-REx-ID: 1427   OA
M. Lagator, C. Igler, A. Moreno, C. C. Guet, and J. P. Bollback, “Epistatic interactions in the arabinose cis-regulatory element,” Molecular Biology and Evolution, vol. 33, no. 3, pp. 761–769, 2016.
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2016 | Journal Article | IST-REx-ID: 1170
M. Lang and J. Stelling, “Modular parameter identification of biomolecular networks,” SIAM Journal on Scientific Computing, vol. 38, no. 6, pp. B988–B1008, 2016.
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2016 | Journal Article | IST-REx-ID: 1290   OA
L. Stone, M. Baym, T. Lieberman, R. P. Chait, J. Clardy, and R. Kishony, “Compounds that select against the tetracycline-resistance efflux pump,” Nature Chemical Biology, vol. 12, no. 11, pp. 902–904, 2016.
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2016 | Conference Paper | IST-REx-ID: 1524   OA
A. Beica, C. C. Guet, and T. Petrov, “Efficient reduction of kappa models by static inspection of the rule-set,” presented at the HSB: Hybrid Systems Biology, Madrid, Spain, 2016, vol. 9271, pp. 173–191.
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2016 | Conference Paper | IST-REx-ID: 1093
P. Daca, T. A. Henzinger, J. Kretinsky, and T. Petrov, “Linear distances between Markov chains,” presented at the CONCUR: Concurrency Theory, Quebec City; Canada, 2016, vol. 59.
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2016 | Journal Article | IST-REx-ID: 1358
T. Friedlander, R. Prizak, C. C. Guet, N. H. Barton, and G. Tkacik, “Intrinsic limits to gene regulation by global crosstalk,” Nature Communications, vol. 7, p. 12307, 2016.
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2016 | Journal Article | IST-REx-ID: 1359   OA
T. Paixao and N. H. Barton, “The effect of gene interactions on the long-term response to selection,” PNAS, vol. 113, no. 16, pp. 4422–4427, 2016.
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2016 | Journal Article | IST-REx-ID: 1342   OA
M. Baym et al., “Spatiotemporal microbial evolution on antibiotic landscapes,” Science, vol. 353, no. 6304, pp. 1147–1151, 2016.
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2016 | Conference Paper | IST-REx-ID: 1234
P. Daca, T. A. Henzinger, J. Kretinsky, and T. Petrov, “Faster statistical model checking for unbounded temporal properties,” presented at the TACAS: Tools and Algorithms for the Construction and Analysis of Systems, Eindhoven, The Netherlands, 2016, vol. 9636, pp. 112–129.
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2015 | Journal Article | IST-REx-ID: 1666
M. Tugrul, T. Paixao, N. H. Barton, and G. Tkacik, “Dynamics of transcription factor binding site evolution,” PLoS Genetics, vol. 11, no. 11, 2015.
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2015 | Journal Article | IST-REx-ID: 1542   OA
T. Paixao et al., “Toward a unifying framework for evolutionary processes,” Journal of Theoretical Biology, vol. 383, pp. 28–43, 2015.
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2015 | Journal Article | IST-REx-ID: 1840   OA
B. Geiger, T. Petrov, G. Kubin, and H. Koeppl, “Optimal Kullback-Leibler aggregation via information bottleneck,” IEEE Transactions on Automatic Control, vol. 60, no. 4, pp. 1010–1022, 2015.
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2015 | Conference Paper | IST-REx-ID: 1430   OA
T. Paixao, D. Sudholt, J. Heredia, and B. Trubenova, “First steps towards a runtime comparison of natural and artificial evolution,” in Proceedings of the 2015 Annual Conference on Genetic and Evolutionary Computation, Madrid, Spain, 2015, pp. 1455–1462.
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2015 | Conference Paper | IST-REx-ID: 1835
M. Giacobbe, C. C. Guet, A. Gupta, T. A. Henzinger, T. Paixao, and T. Petrov, “Model checking gene regulatory networks,” vol. 9035. Springer, pp. 469–483, 2015.
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2015 | Journal Article | IST-REx-ID: 5749   OA
S. Wielgoss, T. Bergmiller, A. M. Bischofberger, and A. R. Hall, “Adaptation to Parasites and Costs of Parasite Resistance in Mutator and Nonmutator Bacteria,” Molecular Biology and Evolution, vol. 33, no. 3, pp. 770–782, 2015.
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2014 | Journal Article | IST-REx-ID: 1894   OA
A. Grabowska et al., “Functional and bioinformatics analysis of two Campylobacter jejuni homologs of the thiol-disulfide oxidoreductase, DsbA,” PLoS One, vol. 9, no. 9, 2014.
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2014 | Journal Article | IST-REx-ID: 2056   OA
A. Ganguly, T. Petrov, and H. Koeppl, “Markov chain aggregation and its applications to combinatorial reaction networks,” Journal of Mathematical Biology, vol. 69, no. 3, pp. 767–797, 2014.
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2014 | Journal Article | IST-REx-ID: 2083
M. Lagator, A. Morgan, P. Neve, and N. Colegrave, “Role of sex and migration in adaptation to sink environments,” Evolution, vol. 68, no. 8, pp. 2296–2305, 2014.
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2014 | Journal Article | IST-REx-ID: 1913
I. Milenković, T. Petrov, and G. Kovács, “Patterns of hippocampal tau pathology differentiate neurodegenerative dementias,” Dementia and Geriatric Cognitive Disorders, vol. 38, no. 5–6, pp. 375–388, 2014.
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2014 | Journal Article | IST-REx-ID: 2036   OA
M. Lagator, N. Colegrave, and P. Neve, “Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses,” Proceedings of the Royal Society of London Series B Biological Sciences, vol. 281, no. 1794, 2014.
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2013 | Conference Paper | IST-REx-ID: 2718   OA
N. H. Barton and T. Paixao, “Can quantitative and population genetics help us understand evolutionary computation?,” in Proceedings of the 15th annual conference on Genetic and evolutionary computation, Amsterdam, Netherlands, 2013, pp. 1573–1580.
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2013 | Journal Article | IST-REx-ID: 2720   OA
H. Long, T. Paixao, R. Azevedo, and R. Zufall, “Accumulation of spontaneous mutations in the ciliate Tetrahymena thermophila,” Genetics, vol. 195, no. 2, pp. 527–540, 2013.
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2013 | Journal Article | IST-REx-ID: 499
Y. Wakamoto et al., “Dynamic persistence of antibiotic-stressed mycobacteria,” Science, vol. 339, no. 6115, pp. 91–95, 2013.
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2013 | Conference Paper | IST-REx-ID: 2719
T. Paixao and N. H. Barton, “A variance decomposition approach to the analysis of genetic algorithms,” in Proceedings of the 15th annual conference on Genetic and evolutionary computation, Amsterdam, Netherlands, 2013, pp. 845–852.
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2013 | Journal Article | IST-REx-ID: 2853   OA
D. Refardt, T. Bergmiller, and R. Kümmerli, “Altruism can evolve when relatedness is low: Evidence from bacteria committing suicide upon phage infection,” Proceedings of the Royal Society of London Series B Biological Sciences, vol. 280, no. 1759, 2013.
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2012 | Journal Article | IST-REx-ID: 2943   OA
N. Hadizadeh Yazdi, C. C. Guet, R. Johnson, and J. Marko, “Variation of the folding and dynamics of the Escherichia coli chromosome with growth conditions,” Molecular Microbiology, vol. 86, no. 6, pp. 1318–1333, 2012.
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2012 | Conference Paper | IST-REx-ID: 3136
C. C. Guet, A. Gupta, T. A. Henzinger, M. Mateescu, and A. Sezgin, “Delayed continuous time Markov chains for genetic regulatory circuits,” presented at the CAV: Computer Aided Verification, Berkeley, CA, USA, 2012, vol. 7358, pp. 294–309.
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2012 | Journal Article | IST-REx-ID: 2302
T. A. Henzinger and M. Mateescu, “The propagation approach for computing biochemical reaction networks,” IEEE ACM Transactions on Computational Biology and Bioinformatics, vol. 10, no. 2, pp. 310–322, 2012.
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2012 | Journal Article | IST-REx-ID: 3130   OA
T. Bergmiller, M. Ackermann, and O. Silander, “Patterns of evolutionary conservation of essential genes correlate with their compensability,” PLoS Genetics, vol. 8, no. 6, 2012.
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2011 | Journal Article | IST-REx-ID: 6496   OA
H. Park, P. Oikonomou, C. C. Guet, and P. Cluzel, “Noise underlies switching behavior of the bacterial flagellum,” Biophysical Journal, vol. 101, no. 10, pp. 2336–2340, 2011.
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2010 | Conference Paper | IST-REx-ID: 3719   OA
J. Feret, T. A. Henzinger, H. Koeppl, and T. Petrov, “Lumpability abstractions of rule-based systems,” presented at the MECBIC: Membrane Computing and Biologically Inspired Process Calculi, Jena, Germany, 2010, vol. 40, pp. 142–161.
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2010 | Conference Paper | IST-REx-ID: 3847   OA
F. Didier, T. A. Henzinger, M. Mateescu, and V. Wolf, “SABRE: A tool for the stochastic analysis of biochemical reaction networks,” presented at the QEST: Quantitative Evaluation of Systems, Williamsburg, USA, 2010, pp. 193–194.
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2009 | Conference Paper | IST-REx-ID: 3843
F. Didier, T. A. Henzinger, M. Mateescu, and V. Wolf, “Fast adaptive uniformization of the chemical master equation,” presented at the HIBI: High-Performance Computational Systems Biology, Trento, Italy, 2009, vol. 4, no. 6, pp. 118–127.
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