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79 Publications

2019 | Journal Article | IST-REx-ID: 6717   OA
Commentary: A host-produced quorum-sensing autoinducer controls a phage lysis-lysogeny decision
C. Igler, S.T. Abedon, Frontiers in Microbiology 10 (2019) 1171.
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2019 | Journal Article | IST-REx-ID: 6465   OA
A modular degron library for synthetic circuits in mammalian cells
H. Chassin, M. Müller, M. Tigges, L. Scheller, M. Lang, M. Fussenegger, Nature Communications 10 (2019) 2013.
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2019 | Thesis | IST-REx-ID: 6371
On the nature of gene regulatory design - The biophysics of transcription factor binding shapes gene regulation
C. Igler, On the Nature of Gene Regulatory Design - The Biophysics of Transcription Factor Binding Shapes Gene Regulation, IST Austria, 2019.
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2019 | Journal Article | IST-REx-ID: 138   OA View | Files available | DOI
 
2019 | Journal Article | IST-REx-ID: 6784   OA
Molecular noise of innate immunity shapes bacteria-phage ecologies
J. Ruess, M. Pleska, C.C. Guet, G. Tkačik, PLoS Computational Biology 15 (2019).
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2018 | Journal Article | IST-REx-ID: 67
Evolutionary potential of transcription factors for gene regulatory rewiring
C. Igler, M. Lagator, G. Tkacik, J.P. Bollback, C.C. Guet, Nature Ecology and Evolution 2 (2018) 1633–1643.
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2018 | Research Data | IST-REx-ID: 5569   OA
Time-lapse microscopy data
T. Bergmiller, N. Nikolic, Time-Lapse Microscopy Data, IST Austria, 2018.
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2018 | Journal Article | IST-REx-ID: 82   OA
Leaky resistance and the conditions for the existence of lytic bacteriophage
W. Chaudhry, M. Pleska, N. Shah, H. Weiss, I. Mccall, J. Meyer, A. Gupta, C.C. Guet, B. Levin, PLoS Biology 16 (2018).
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2018 | Journal Article | IST-REx-ID: 19   OA
Nonoptimal gene expression creates latent potential for antibiotic resistance
A. Palmer, R.P. Chait, R. Kishony, Molecular Biology and Evolution 35 (2018) 2669–2684.
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2018 | Preprint | IST-REx-ID: 196   OA
Harmonic dynamics of the Abelian sandpile
M. Lang, M. Shkolnikov, ArXiv (2018).
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2018 | Journal Article | IST-REx-ID: 305
Fabrication and operation of microfluidic hanging drop networks
P. Misun, A. Birchler, M. Lang, A. Hierlemann, O. Frey, Methods in Molecular Biology 1771 (2018) 183–202.
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2018 | Journal Article | IST-REx-ID: 723   OA
How to escape local optima in black box optimisation when non elitism outperforms elitism
P. Oliveto, T. Paixao, J. Pérez Heredia, D. Sudholt, B. Trubenova, Algorithmica 80 (2018) 1604–1633.
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2018 | Thesis | IST-REx-ID: 26
The influence of sequence context on the evolution of bacterial gene expression
M. Steinrück, The Influence of Sequence Context on the Evolution of Bacterial Gene Expression, IST Austria, 2018.
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2018 | Journal Article | IST-REx-ID: 503 View | DOI
 
2018 | Journal Article | IST-REx-ID: 438
Autoregulation of mazEF expression underlies growth heterogeneity in bacterial populations
N. Nikolic, T. Bergmiller, A. Vandervelde, T. Albanese, L. Gelens, I. Moll, Nucleic Acids Research 46 (2018) 2918–2931.
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2018 | Journal Article | IST-REx-ID: 161
Statistical mechanics for metabolic networks during steady state growth
D. De Martino, A.A. Mc, T. Bergmiller, C.C. Guet, G. Tkacik, Nature Communications 9 (2018) 2988.
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2018 | Journal Article | IST-REx-ID: 5984   OA
Optical functionalization of human class A orphan G-protein-coupled receptors
M. Morri, I. Sanchez-Romero, A.-M. Tichy, S. Kainrath, E.J. Gerrard, P. Hirschfeld, J. Schwarz, H.L. Janovjak, Nature Communications 9 (2018).
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2018 | Research Data | IST-REx-ID: 5585
Data for the paper Evolutionary potential of transcription factors for gene regulatory rewiring
C. Igler, M. Lagator, G. Tkacik, J.P. Bollback, C.C. Guet, Data for the Paper Evolutionary Potential of Transcription Factors for Gene Regulatory Rewiring, IST Austria, 2018.
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2018 | Journal Article | IST-REx-ID: 457
Phage-host population dynamics promotes prophage acquisition in bacteria with innate immunity
M. Pleska, M. Lang, D. Refardt, B. Levin, C.C. Guet, Nature Ecology and Evolution 2 (2018) 359–366.
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2017 | Journal Article | IST-REx-ID: 1084
Insulation and wiring specificity of BceR like response regulators and their target promoters in Bacillus subtilis
C. Fang, A.A. Nagy-Staron, M. Grafe, R. Heermann, K. Jung, S. Gebhard, T. Mascher, Molecular Microbiology 104 (2017) 16–31.
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2017 | Journal Article | IST-REx-ID: 1351
Model checking the evolution of gene regulatory networks
M. Giacobbe, C.C. Guet, A. Gupta, T.A. Henzinger, T. Paixao, T. Petrov, Acta Informatica 54 (2017) 765–787.
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2017 | Journal Article | IST-REx-ID: 624   OA View | Files available | DOI
 
2017 | Journal Article | IST-REx-ID: 655   OA
Bacterial flagella grow through an injection diffusion mechanism
T. Renault, A. Abraham, T. Bergmiller, G. Paradis, S. Rainville, E. Charpentier, C.C. Guet, Y. Tu, K. Namba, J. Keener, T. Minamino, M. Erhardt, ELife 6 (2017).
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2017 | Journal Article | IST-REx-ID: 561 View | Files available | DOI
 
2017 | Journal Article | IST-REx-ID: 613   OA
Shaping bacterial population behavior through computer interfaced control of individual cells
R.P. Chait, J. Ruess, T. Bergmiller, G. Tkacik, C.C. Guet, Nature Communications 8 (2017).
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2017 | Journal Article | IST-REx-ID: 954   OA
On the mechanistic nature of epistasis in a canonical cis-regulatory element
M. Lagator, T. Paixao, N.H. Barton, J.P. Bollback, C.C. Guet, ELife 6 (2017).
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2017 | Thesis | IST-REx-ID: 202   OA
Biology of restriction-modification systems at the single-cell and population level
M. Pleska, Biology of Restriction-Modification Systems at the Single-Cell and Population Level, IST Austria, 2017.
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2017 | Journal Article | IST-REx-ID: 1028
Green-light-induced inactivation of receptor signaling using cobalamin-binding domains
S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie - International Edition 56 (2017) 4608–4611.
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2017 | Journal Article | IST-REx-ID: 570   OA
Regulatory network structure determines patterns of intermolecular epistasis
M. Lagator, S. Sarikas, H. Acar, J.P. Bollback, C.C. Guet, ELife 6 (2017).
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2017 | Research Data | IST-REx-ID: 5564
Fastq files for "Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection"
M. Steinrück, C.C. Guet, Fastq Files for “Complex Chromosomal Neighborhood Effects Determine the Adaptive Potential of a Gene under Selection,” IST Austria, 2017.
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2017 | Journal Article | IST-REx-ID: 538   OA
Grünlicht-induzierte Rezeptorinaktivierung durch Cobalamin-bindende Domänen
S. Kainrath, M. Stadler, E. Gschaider-Reichhart, M. Distel, H.L. Janovjak, Angewandte Chemie 129 (2017) 4679–4682.
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2017 | Journal Article | IST-REx-ID: 665
Biased partitioning of the multidrug efflux pump AcrAB TolC underlies long lived phenotypic heterogeneity
T. Bergmiller, A.M. Andersson, K. Tomasek, E. Balleza, D. Kiviet, R. Hauschild, G. Tkacik, C.C. Guet, Science 356 (2017) 311–315.
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2017 | Research Data | IST-REx-ID: 5560
Biased partitioning of the multi-drug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity
T. Bergmiller, A.M. Andersson, K. Tomasek, E. Balleza, D. Kiviet, R. Hauschild, G. Tkacik, C.C. Guet, Biased Partitioning of the Multi-Drug Efflux Pump AcrAB-TolC Underlies Long-Lived Phenotypic Heterogeneity, IST Austria, 2017.
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2017 | Journal Article | IST-REx-ID: 735
An effective feedback loop between cell-cell contact duration and morphogen signaling determines cell fate
V. Barone, M. Lang, G. Krens, S. Pradhan, S. Shamipour, K. Sako, M.K. Sikora, C.C. Guet, C.-P.J. Heisenberg, Developmental Cell 43 (2017) 198–211.
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2017 | Journal Article | IST-REx-ID: 704 View | Files available | DOI
 
2017 | Journal Article | IST-REx-ID: 696
Stress induced mutagenesis: Stress diversity facilitates the persistence of mutator genes
M. Lukacisinova, S. Novak, T. Paixao, PLoS Computational Biology 13 (2017).
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2017 | Journal Article | IST-REx-ID: 1007   OA
Zeros of nonlinear systems with input invariances
M. Lang, E. Sontag, Automatica 81C (2017) 46–55.
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2017 | Journal Article | IST-REx-ID: 1336   OA
Towards a runtime comparison of natural and artificial evolution
T. Paixao, J. Pérez Heredia, D. Sudholt, B. Trubenova, Algorithmica 78 (2017) 681–713.
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2017 | Journal Article | IST-REx-ID: 541   OA
Cell-to-cell variation and specialization in sugar metabolism in clonal bacterial populations
N. Nikolic, F. Schreiber, A. Dal Co, D. Kiviet, T. Bergmiller, S. Littmann, M. Kuypers, M. Ackermann, PLoS Genetics 13 (2017).
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2016 | Journal Article | IST-REx-ID: 1008
An orthogonal permease–inducer–repressor feedback loop shows bistability
R. Gnügge, L. Dharmarajan, M. Lang, J. Stelling, ACS Synthetic Biology 5 (2016) 1098–1107.
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2016 | Journal Article | IST-REx-ID: 1250   OA
Genetic manipulation of glycogen allocation affects replicative lifespan in E coli
A. Boehm, M. Arnoldini, T. Bergmiller, T. Röösli, C. Bigosch, M. Ackermann, PLoS Genetics 12 (2016).
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2016 | Conference Paper | IST-REx-ID: 1320 View | Files available | DOI
 
2016 | Conference Paper | IST-REx-ID: 1349   OA
When non-elitism outperforms elitism for crossing fitness valleys
P. Oliveto, T. Paixao, J. Heredia, D. Sudholt, B. Trubenova, in:, Proceedings of the Genetic and Evolutionary Computation Conference 2016 , ACM, 2016, pp. 1163–1170.
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2016 | Journal Article | IST-REx-ID: 1332   OA
Pervasive selection for and against antibiotic resistance in inhomogeneous multistress environments
R.P. Chait, A. Palmer, I. Yelin, R. Kishony, Nature Communications 7 (2016).
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2016 | Journal Article | IST-REx-ID: 1243
Bacterial autoimmunity due to a restriction-modification system
M. Pleska, L. Qian, R. Okura, T. Bergmiller, Y. Wakamoto, E. Kussell, C.C. Guet, Current Biology 26 (2016) 404–409.
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2016 | Conference Paper | IST-REx-ID: 1220   OA
Fuselage boundary layer ingestion propulsion applied to a thin haul commuter aircraft for optimal efficiency
G. Mikić, A. Stoll, J. Bevirt, R. Grah, M. Moore, in:, AIAA, 2016, pp. 1–19.
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2016 | Journal Article | IST-REx-ID: 1427   OA
Epistatic interactions in the arabinose cis-regulatory element
M. Lagator, C. Igler, A. Moreno, C.C. Guet, J.P. Bollback, Molecular Biology and Evolution 33 (2016) 761–769.
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2016 | Journal Article | IST-REx-ID: 1170
Modular parameter identification of biomolecular networks
M. Lang, J. Stelling, SIAM Journal on Scientific Computing 38 (2016) B988–B1008.
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2016 | Journal Article | IST-REx-ID: 1290   OA
Compounds that select against the tetracycline-resistance efflux pump
L. Stone, M. Baym, T. Lieberman, R.P. Chait, J. Clardy, R. Kishony, Nature Chemical Biology 12 (2016) 902–904.
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2016 | Conference Paper | IST-REx-ID: 1524   OA
Efficient reduction of kappa models by static inspection of the rule-set
A. Beica, C.C. Guet, T. Petrov, in:, Springer, 2016, pp. 173–191.
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2016 | Conference Paper | IST-REx-ID: 1093
Linear distances between Markov chains
P. Daca, T.A. Henzinger, J. Kretinsky, T. Petrov, in:, Schloss Dagstuhl - Leibniz-Zentrum für Informatik, 2016.
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2016 | Journal Article | IST-REx-ID: 1358
Intrinsic limits to gene regulation by global crosstalk
T. Friedlander, R. Prizak, C.C. Guet, N.H. Barton, G. Tkacik, Nature Communications 7 (2016) 12307.
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2016 | Journal Article | IST-REx-ID: 1359   OA
The effect of gene interactions on the long-term response to selection
T. Paixao, N.H. Barton, PNAS 113 (2016) 4422–4427.
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2016 | Journal Article | IST-REx-ID: 1342   OA
Spatiotemporal microbial evolution on antibiotic landscapes
M. Baym, T. Lieberman, E. Kelsic, R.P. Chait, R. Gross, I. Yelin, R. Kishony, Science 353 (2016) 1147–1151.
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2016 | Conference Paper | IST-REx-ID: 1234
Faster statistical model checking for unbounded temporal properties
P. Daca, T.A. Henzinger, J. Kretinsky, T. Petrov, in:, Springer, 2016, pp. 112–129.
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2015 | Journal Article | IST-REx-ID: 1666
Dynamics of transcription factor binding site evolution
M. Tugrul, T. Paixao, N.H. Barton, G. Tkacik, PLoS Genetics 11 (2015).
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2015 | Journal Article | IST-REx-ID: 1542   OA
Toward a unifying framework for evolutionary processes
T. Paixao, G. Badkobeh, N.H. Barton, D. Çörüş, D. Dang, T. Friedrich, P. Lehre, D. Sudholt, A. Sutton, B. Trubenova, Journal of Theoretical Biology 383 (2015) 28–43.
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2015 | Journal Article | IST-REx-ID: 1840   OA
Optimal Kullback-Leibler aggregation via information bottleneck
B. Geiger, T. Petrov, G. Kubin, H. Koeppl, IEEE Transactions on Automatic Control 60 (2015) 1010–1022.
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2015 | Conference Paper | IST-REx-ID: 1430   OA
First steps towards a runtime comparison of natural and artificial evolution
T. Paixao, D. Sudholt, J. Heredia, B. Trubenova, in:, Proceedings of the 2015 Annual Conference on Genetic and Evolutionary Computation, ACM, 2015, pp. 1455–1462.
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2015 | Conference Paper | IST-REx-ID: 1835   OA
Model checking gene regulatory networks
M. Giacobbe, C.C. Guet, A. Gupta, T.A. Henzinger, T. Paixao, T. Petrov, 9035 (2015) 469–483.
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2015 | Journal Article | IST-REx-ID: 5749   OA
Adaptation to Parasites and Costs of Parasite Resistance in Mutator and Nonmutator Bacteria
S. Wielgoss, T. Bergmiller, A.M. Bischofberger, A.R. Hall, Molecular Biology and Evolution 33 (2015) 770–782.
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2014 | Journal Article | IST-REx-ID: 1894   OA
Functional and bioinformatics analysis of two Campylobacter jejuni homologs of the thiol-disulfide oxidoreductase, DsbA
A. Grabowska, E. Wywiał, S. Dunin Horkawicz, A. Łasica, M. Wösten, A.A. Nagy-Staron, R. Godlewska, K. Bocian Ostrzycka, K. Pieńkowska, P. Łaniewski, J. Bujnicki, J. Van Putten, E. Jagusztyn Krynicka, PLoS One 9 (2014).
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2014 | Journal Article | IST-REx-ID: 2056   OA
Markov chain aggregation and its applications to combinatorial reaction networks
A. Ganguly, T. Petrov, H. Koeppl, Journal of Mathematical Biology 69 (2014) 767–797.
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2014 | Journal Article | IST-REx-ID: 2083
Role of sex and migration in adaptation to sink environments
M. Lagator, A. Morgan, P. Neve, N. Colegrave, Evolution 68 (2014) 2296–2305.
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2014 | Journal Article | IST-REx-ID: 1913
Patterns of hippocampal tau pathology differentiate neurodegenerative dementias
I. Milenković, T. Petrov, G. Kovács, Dementia and Geriatric Cognitive Disorders 38 (2014) 375–388.
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2014 | Journal Article | IST-REx-ID: 2036   OA
Selection history and epistatic interactions impact dynamics of adaptation to novel environmental stresses
M. Lagator, N. Colegrave, P. Neve, Proceedings of the Royal Society of London Series B Biological Sciences 281 (2014).
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2013 | Conference Paper | IST-REx-ID: 2718   OA
Can quantitative and population genetics help us understand evolutionary computation?
N.H. Barton, T. Paixao, in:, Proceedings of the 15th Annual Conference on Genetic and Evolutionary Computation, ACM, 2013, pp. 1573–1580.
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2013 | Journal Article | IST-REx-ID: 2720   OA
Accumulation of spontaneous mutations in the ciliate Tetrahymena thermophila
H. Long, T. Paixao, R. Azevedo, R. Zufall, Genetics 195 (2013) 527–540.
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2013 | Journal Article | IST-REx-ID: 499
Dynamic persistence of antibiotic-stressed mycobacteria
Y. Wakamoto, N. Dhar, R.P. Chait, K. Schneider, F. Signorino Gelo, S. Leibler, J. Mckinney, Science 339 (2013) 91–95.
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2013 | Conference Paper | IST-REx-ID: 2719
A variance decomposition approach to the analysis of genetic algorithms
T. Paixao, N.H. Barton, in:, Proceedings of the 15th Annual Conference on Genetic and Evolutionary Computation, ACM, 2013, pp. 845–852.
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2013 | Journal Article | IST-REx-ID: 2853   OA
Altruism can evolve when relatedness is low: Evidence from bacteria committing suicide upon phage infection
D. Refardt, T. Bergmiller, R. Kümmerli, Proceedings of the Royal Society of London Series B Biological Sciences 280 (2013).
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2012 | Journal Article | IST-REx-ID: 2943   OA
Variation of the folding and dynamics of the Escherichia coli chromosome with growth conditions
N. Hadizadeh Yazdi, C.C. Guet, R. Johnson, J. Marko, Molecular Microbiology 86 (2012) 1318–1333.
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2012 | Conference Paper | IST-REx-ID: 3136
Delayed continuous time Markov chains for genetic regulatory circuits
C.C. Guet, A. Gupta, T.A. Henzinger, M. Mateescu, A. Sezgin, in:, Springer, 2012, pp. 294–309.
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2012 | Journal Article | IST-REx-ID: 2302
The propagation approach for computing biochemical reaction networks
T.A. Henzinger, M. Mateescu, IEEE ACM Transactions on Computational Biology and Bioinformatics 10 (2012) 310–322.
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2012 | Journal Article | IST-REx-ID: 3130   OA
Patterns of evolutionary conservation of essential genes correlate with their compensability
T. Bergmiller, M. Ackermann, O. Silander, PLoS Genetics 8 (2012).
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2011 | Journal Article | IST-REx-ID: 6496   OA
Noise underlies switching behavior of the bacterial flagellum
H. Park, P. Oikonomou, C.C. Guet, P. Cluzel, Biophysical Journal 101 (2011) 2336–2340.
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2010 | Conference Paper | IST-REx-ID: 3719   OA
Lumpability abstractions of rule-based systems
J. Feret, T.A. Henzinger, H. Koeppl, T. Petrov, in:, Open Publishing Association, 2010, pp. 142–161.
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2010 | Conference Paper | IST-REx-ID: 3847   OA
SABRE: A tool for the stochastic analysis of biochemical reaction networks
F. Didier, T.A. Henzinger, M. Mateescu, V. Wolf, in:, IEEE, 2010, pp. 193–194.
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2009 | Conference Paper | IST-REx-ID: 3843
Fast adaptive uniformization of the chemical master equation
F. Didier, T.A. Henzinger, M. Mateescu, V. Wolf, in:, IEEE, 2009, pp. 118–127.
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