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We show that one gene regulatory network with fixed topology can display not only quantitatively but also qualitatively different phenotypes, depending solely on the local genetic context of its components. Our results demonstrate that changes in local genetic context can place a single transcriptional unit within two separate regulons without the need for complex regulatory sequences. 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Data for the paper Evolutionary potential of transcription factors for gene regulatory rewiring, Institute of Science and Technology Austria, 10.15479/AT:ISTA:108."},"file_date_updated":"2020-07-14T12:47:07Z","department":[{"_id":"CaGu"},{"_id":"GaTk"}],"title":"Data for the paper Evolutionary potential of transcription factors for gene regulatory rewiring","article_processing_charge":"No","author":[{"last_name":"Igler","full_name":"Igler, Claudia","first_name":"Claudia","id":"46613666-F248-11E8-B48F-1D18A9856A87"},{"id":"345D25EC-F248-11E8-B48F-1D18A9856A87","first_name":"Mato","last_name":"Lagator","full_name":"Lagator, Mato"},{"last_name":"Tkacik","orcid":"0000-0002-6699-1455","full_name":"Tkacik, Gasper","first_name":"Gasper","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87"},{"last_name":"Bollback","orcid":"0000-0002-4624-4612","full_name":"Bollback, Jonathan P","first_name":"Jonathan P","id":"2C6FA9CC-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0001-6220-2052","full_name":"Guet, Calin C","last_name":"Guet","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","first_name":"Calin C"}],"_id":"5585","project":[{"_id":"25681D80-B435-11E9-9278-68D0E5697425","call_identifier":"FP7","name":"International IST Postdoc Fellowship Programme","grant_number":"291734"},{"grant_number":"648440","name":"Selective Barriers to Horizontal Gene Transfer","call_identifier":"H2020","_id":"2578D616-B435-11E9-9278-68D0E5697425"},{"name":"Design principles underlying genetic switch architecture (DOC Fellowship)","grant_number":"24573","_id":"251EE76E-B435-11E9-9278-68D0E5697425"}],"status":"public","tmp":{"image":"/images/cc_0.png","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","name":"Creative Commons Public Domain Dedication (CC0 1.0)","short":"CC0 (1.0)"},"type":"research_data"},{"_id":"5564","status":"public","type":"research_data","tmp":{"image":"/images/cc_0.png","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","name":"Creative Commons Public Domain Dedication (CC0 1.0)","short":"CC0 (1.0)"},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["576"],"date_updated":"2024-02-21T13:47:28Z","citation":{"chicago":"Steinrück, Magdalena, and Calin C Guet. “Fastq Files for ‘Complex Chromosomal Neighborhood Effects Determine the Adaptive Potential of a Gene under Selection.’” Institute of Science and Technology Austria, 2017. https://doi.org/10.15479/AT:ISTA:65.","ista":"Steinrück M, Guet CC. 2017. Fastq files for ‘Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection’, Institute of Science and Technology Austria, 10.15479/AT:ISTA:65.","mla":"Steinrück, Magdalena, and Calin C. Guet. Fastq Files for “Complex Chromosomal Neighborhood Effects Determine the Adaptive Potential of a Gene under Selection.” Institute of Science and Technology Austria, 2017, doi:10.15479/AT:ISTA:65.","short":"M. Steinrück, C.C. Guet, (2017).","ieee":"M. Steinrück and C. C. Guet, “Fastq files for ‘Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection.’” Institute of Science and Technology Austria, 2017.","apa":"Steinrück, M., & Guet, C. C. (2017). Fastq files for “Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection.” Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:65","ama":"Steinrück M, Guet CC. Fastq files for “Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection.” 2017. doi:10.15479/AT:ISTA:65"},"department":[{"_id":"CaGu"}],"title":"Fastq files for \"Complex chromosomal neighborhood effects determine the adaptive potential of a gene under selection\"","file_date_updated":"2020-07-14T12:47:03Z","author":[{"last_name":"Steinrück","orcid":"0000-0003-1229-9719","full_name":"Steinrück, Magdalena","id":"2C023F40-F248-11E8-B48F-1D18A9856A87","first_name":"Magdalena"},{"last_name":"Guet","orcid":"0000-0001-6220-2052","full_name":"Guet, Calin C","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","first_name":"Calin C"}],"article_processing_charge":"No","oa_version":"Published Version","abstract":[{"lang":"eng","text":"Compressed Fastq files with whole-genome sequencing data of IS-wt strain D and clones from four evolved populations (A11, C08, C10, D08). Information on this data collection is available in the Methods Section of the primary publication."}],"month":"04","publisher":"Institute of Science and Technology Austria","oa":1,"day":"11","file":[{"file_id":"5627","checksum":"31a0c01d022721073241a23d192cc37e","content_type":"application/zip","relation":"main_file","access_level":"open_access","file_name":"IST-2017-65-v1+1_D_anc_1.fastq.zip","date_created":"2018-12-12T13:03:18Z","file_size":1225959109,"date_updated":"2020-07-14T12:47:03Z","creator":"system"},{"content_type":"application/zip","access_level":"open_access","relation":"main_file","checksum":"d8f26f83ce7e7e45436121f9c6cd9b83","file_id":"5628","date_updated":"2020-07-14T12:47:03Z","file_size":1422656107,"creator":"system","date_created":"2018-12-12T13:03:30Z","file_name":"IST-2017-65-v1+1_D_anc_2.fastq.zip"},{"file_id":"5629","checksum":"e07b99bcfe55b5f132ca03b8b48c8cbc","access_level":"open_access","relation":"main_file","content_type":"application/zip","date_created":"2018-12-12T13:03:33Z","file_name":"IST-2017-65-v1+2_D_A11_1.fastq.zip","creator":"system","date_updated":"2020-07-14T12:47:03Z","file_size":565014975},{"content_type":"application/zip","relation":"main_file","access_level":"open_access","checksum":"eda86143d5f32d844b54f8530041e32b","file_id":"5630","file_size":564490030,"date_updated":"2020-07-14T12:47:03Z","creator":"system","file_name":"IST-2017-65-v1+3_D_A11_2.fastq.zip","date_created":"2018-12-12T13:03:42Z"},{"date_updated":"2020-07-14T12:47:03Z","file_size":875430169,"creator":"system","date_created":"2018-12-12T13:03:46Z","file_name":"IST-2017-65-v1+4_D_C10_1.fastq.zip","content_type":"application/zip","access_level":"open_access","relation":"main_file","checksum":"906d44f950c1626d9b99f34fbf89cb12","file_id":"5631"},{"relation":"main_file","access_level":"open_access","content_type":"application/zip","checksum":"6ca14a032a79e0c787106bdf635725c9","file_id":"5632","creator":"system","file_size":638298201,"date_updated":"2020-07-14T12:47:03Z","file_name":"IST-2017-65-v1+6_D_C08_2.fastq.zip","date_created":"2018-12-12T13:03:54Z"},{"file_name":"IST-2017-65-v1+5_D_C10_2.fastq.zip","date_created":"2018-12-12T13:04:01Z","file_size":894702866,"date_updated":"2020-07-14T12:47:03Z","creator":"system","checksum":"66ab16ddb5ba64b2e263ef746ebf2893","file_id":"5633","content_type":"application/zip","relation":"main_file","access_level":"open_access"},{"file_name":"IST-2017-65-v1+7_D_C08_1.fastq.zip","date_created":"2018-12-12T13:04:07Z","creator":"system","file_size":623648989,"date_updated":"2020-07-14T12:47:03Z","checksum":"82607970174f8d37773b7d3acc712195","file_id":"5634","relation":"main_file","access_level":"open_access","content_type":"application/zip"},{"checksum":"225c30b243268c7dda9d6f8327933252","file_id":"5635","access_level":"open_access","relation":"main_file","content_type":"application/zip","date_created":"2018-12-12T13:04:11Z","file_name":"IST-2017-65-v1+8_D_D08_1.fastq.zip","creator":"system","date_updated":"2020-07-14T12:47:03Z","file_size":259359583}],"has_accepted_license":"1","datarep_id":"65","year":"2017","date_published":"2017-04-11T00:00:00Z","related_material":{"record":[{"status":"public","id":"704","relation":"research_paper"}]},"doi":"10.15479/AT:ISTA:65","date_created":"2018-12-12T12:31:33Z"},{"year":"2017","datarep_id":"53","has_accepted_license":"1","day":"10","file":[{"content_type":"application/zip","relation":"main_file","access_level":"open_access","checksum":"d77859af757ac8025c50c7b12b52eaf3","file_id":"5603","file_size":6773204,"date_updated":"2020-07-14T12:47:03Z","creator":"system","file_name":"IST-2017-53-v1+1_Data_MDE.zip","date_created":"2018-12-12T13:02:38Z"}],"date_created":"2018-12-12T12:31:32Z","related_material":{"record":[{"id":"665","status":"public","relation":"research_paper"}]},"doi":"10.15479/AT:ISTA:53","date_published":"2017-03-10T00:00:00Z","abstract":[{"text":"This repository contains the data collected for the manuscript \"Biased partitioning of the multi-drug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity\".\r\nThe data is compressed into a single archive. Within the archive, different folders correspond to figures of the main text and the SI of the related publication.\r\nData is saved as plain text, with each folder containing a separate readme file describing the format. Typically, the data is from fluorescence microscopy measurements of single cells growing in a microfluidic \"mother machine\" device, and consists of relevant values (primarily arbitrary unit or normalized fluorescence measurements, and division times / growth rates) after raw microscopy images have been processed, segmented, and their features extracted, as described in the methods section of the related publication.","lang":"eng"}],"oa_version":"Published Version","oa":1,"publisher":"Institute of Science and Technology Austria","month":"03","date_updated":"2024-02-21T13:49:00Z","citation":{"mla":"Bergmiller, Tobias, et al. Biased Partitioning of the Multi-Drug Efflux Pump AcrAB-TolC Underlies Long-Lived Phenotypic Heterogeneity. Institute of Science and Technology Austria, 2017, doi:10.15479/AT:ISTA:53.","apa":"Bergmiller, T., Andersson, A. M., Tomasek, K., Balleza, E., Kiviet, D., Hauschild, R., … Guet, C. C. (2017). Biased partitioning of the multi-drug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity. Institute of Science and Technology Austria. https://doi.org/10.15479/AT:ISTA:53","ama":"Bergmiller T, Andersson AM, Tomasek K, et al. Biased partitioning of the multi-drug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity. 2017. doi:10.15479/AT:ISTA:53","ieee":"T. Bergmiller et al., “Biased partitioning of the multi-drug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity.” Institute of Science and Technology Austria, 2017.","short":"T. Bergmiller, A.M. Andersson, K. Tomasek, E. Balleza, D. Kiviet, R. Hauschild, G. Tkačik, C.C. Guet, (2017).","chicago":"Bergmiller, Tobias, Anna M Andersson, Kathrin Tomasek, Enrique Balleza, Daniel Kiviet, Robert Hauschild, Gašper Tkačik, and Calin C Guet. “Biased Partitioning of the Multi-Drug Efflux Pump AcrAB-TolC Underlies Long-Lived Phenotypic Heterogeneity.” Institute of Science and Technology Austria, 2017. https://doi.org/10.15479/AT:ISTA:53.","ista":"Bergmiller T, Andersson AM, Tomasek K, Balleza E, Kiviet D, Hauschild R, Tkačik G, Guet CC. 2017. Biased partitioning of the multi-drug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity, Institute of Science and Technology Austria, 10.15479/AT:ISTA:53."},"user_id":"2DF688A6-F248-11E8-B48F-1D18A9856A87","ddc":["571"],"article_processing_charge":"No","author":[{"first_name":"Tobias","id":"2C471CFA-F248-11E8-B48F-1D18A9856A87","last_name":"Bergmiller","full_name":"Bergmiller, Tobias","orcid":"0000-0001-5396-4346"},{"last_name":"Andersson","full_name":"Andersson, Anna M","orcid":"0000-0003-2912-6769","first_name":"Anna M","id":"2B8A40DA-F248-11E8-B48F-1D18A9856A87"},{"orcid":"0000-0003-3768-877X","full_name":"Tomasek, Kathrin","last_name":"Tomasek","first_name":"Kathrin","id":"3AEC8556-F248-11E8-B48F-1D18A9856A87"},{"first_name":"Enrique","last_name":"Balleza","full_name":"Balleza, Enrique"},{"first_name":"Daniel","full_name":"Kiviet, Daniel","last_name":"Kiviet"},{"last_name":"Hauschild","full_name":"Hauschild, Robert","orcid":"0000-0001-9843-3522","id":"4E01D6B4-F248-11E8-B48F-1D18A9856A87","first_name":"Robert"},{"orcid":"0000-0002-6699-1455","full_name":"Tkacik, Gasper","last_name":"Tkacik","id":"3D494DCA-F248-11E8-B48F-1D18A9856A87","first_name":"Gasper"},{"full_name":"Guet, Calin C","orcid":"0000-0001-6220-2052","last_name":"Guet","id":"47F8433E-F248-11E8-B48F-1D18A9856A87","first_name":"Calin C"}],"department":[{"_id":"CaGu"},{"_id":"GaTk"},{"_id":"Bio"}],"title":"Biased partitioning of the multi-drug efflux pump AcrAB-TolC underlies long-lived phenotypic heterogeneity","file_date_updated":"2020-07-14T12:47:03Z","_id":"5560","tmp":{"image":"/images/cc_0.png","legal_code_url":"https://creativecommons.org/publicdomain/zero/1.0/legalcode","name":"Creative Commons Public Domain Dedication (CC0 1.0)","short":"CC0 (1.0)"},"type":"research_data","keyword":["single cell microscopy","mother machine microfluidic device","AcrAB-TolC pump","multi-drug efflux","Escherichia coli"],"status":"public"}]