---
_id: '2469'
abstract:
- lang: eng
text: Cadherins are transmembrane proteins that mediate cell–cell adhesion in animals.
By regulating contact formation and stability, cadherins play a crucial role in
tissue morphogenesis and homeostasis. Here, we review the three major unctions
of cadherins in cell–cell contact formation and stability. Two of those functions
lead to a decrease in interfacial ension at the forming cell–cell contact, thereby
promoting contact expansion — first, by providing adhesion tension that lowers
interfacial tension at the cell–cell contact, and second, by signaling to the
actomyosin cytoskeleton in order to reduce cortex tension and thus interfacial
tension at the contact. The third function of cadherins in cell–cell contact formation
is to stabilize the contact by resisting mechanical forces that pull on the contact.
author:
- first_name: Jean-Léon
full_name: Maître, Jean-Léon
id: 48F1E0D8-F248-11E8-B48F-1D18A9856A87
last_name: Maître
orcid: 0000-0002-3688-1474
- first_name: Carl-Philipp J
full_name: Heisenberg, Carl-Philipp J
id: 39427864-F248-11E8-B48F-1D18A9856A87
last_name: Heisenberg
orcid: 0000-0002-0912-4566
citation:
ama: Maître J-L, Heisenberg C-PJ. Three functions of cadherins in cell adhesion.
Current Biology. 2013;23(14):R626-R633. doi:10.1016/j.cub.2013.06.019
apa: Maître, J.-L., & Heisenberg, C.-P. J. (2013). Three functions of cadherins
in cell adhesion. Current Biology. Cell Press. https://doi.org/10.1016/j.cub.2013.06.019
chicago: Maître, Jean-Léon, and Carl-Philipp J Heisenberg. “Three Functions of Cadherins
in Cell Adhesion.” Current Biology. Cell Press, 2013. https://doi.org/10.1016/j.cub.2013.06.019.
ieee: J.-L. Maître and C.-P. J. Heisenberg, “Three functions of cadherins in cell
adhesion,” Current Biology, vol. 23, no. 14. Cell Press, pp. R626–R633,
2013.
ista: Maître J-L, Heisenberg C-PJ. 2013. Three functions of cadherins in cell adhesion.
Current Biology. 23(14), R626–R633.
mla: Maître, Jean-Léon, and Carl-Philipp J. Heisenberg. “Three Functions of Cadherins
in Cell Adhesion.” Current Biology, vol. 23, no. 14, Cell Press, 2013,
pp. R626–33, doi:10.1016/j.cub.2013.06.019.
short: J.-L. Maître, C.-P.J. Heisenberg, Current Biology 23 (2013) R626–R633.
date_created: 2018-12-11T11:57:51Z
date_published: 2013-07-22T00:00:00Z
date_updated: 2021-01-12T06:57:40Z
day: '22'
ddc:
- '570'
department:
- _id: CaHe
doi: 10.1016/j.cub.2013.06.019
external_id:
pmid:
- '23885883'
file:
- access_level: open_access
checksum: 6a424b2f007b41d4955a9135793b2162
content_type: application/pdf
creator: dernst
date_created: 2019-01-24T15:40:22Z
date_updated: 2020-07-14T12:45:41Z
file_id: '5881'
file_name: 2013_CurrentBiology_Maitre.pdf
file_size: 247320
relation: main_file
file_date_updated: 2020-07-14T12:45:41Z
has_accepted_license: '1'
intvolume: ' 23'
issue: '14'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
page: R626 - R633
pmid: 1
publication: Current Biology
publication_status: published
publisher: Cell Press
publist_id: '4433'
quality_controlled: '1'
scopus_import: 1
status: public
title: Three functions of cadherins in cell adhesion
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 23
year: '2013'
...
---
_id: '247'
abstract:
- lang: eng
text: An improved estimate is provided for the number of Fq-rational points on a
geometrically irreducible, projective, cubic hypersurface that is not equal to
a cone.
acknowledgement: "EP/E053262/1\tEngineering and Physical Sciences Research Council"
author:
- first_name: Timothy D
full_name: Timothy Browning
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
citation:
ama: Browning TD. The Lang-Weil estimate for cubic hypersurfaces. Canadian Mathematical
Bulletin. 2013;56(3):500-502. doi:10.4153/CMB-2011-177-4
apa: Browning, T. D. (2013). The Lang-Weil estimate for cubic hypersurfaces. Canadian
Mathematical Bulletin. Unknown. https://doi.org/10.4153/CMB-2011-177-4
chicago: Browning, Timothy D. “The Lang-Weil Estimate for Cubic Hypersurfaces.”
Canadian Mathematical Bulletin. Unknown, 2013. https://doi.org/10.4153/CMB-2011-177-4.
ieee: T. D. Browning, “The Lang-Weil estimate for cubic hypersurfaces,” Canadian
Mathematical Bulletin, vol. 56, no. 3. Unknown, pp. 500–502, 2013.
ista: Browning TD. 2013. The Lang-Weil estimate for cubic hypersurfaces. Canadian
Mathematical Bulletin. 56(3), 500–502.
mla: Browning, Timothy D. “The Lang-Weil Estimate for Cubic Hypersurfaces.” Canadian
Mathematical Bulletin, vol. 56, no. 3, Unknown, 2013, pp. 500–02, doi:10.4153/CMB-2011-177-4.
short: T.D. Browning, Canadian Mathematical Bulletin 56 (2013) 500–502.
date_created: 2018-12-11T11:45:25Z
date_published: 2013-08-31T00:00:00Z
date_updated: 2021-01-12T06:57:40Z
day: '31'
doi: 10.4153/CMB-2011-177-4
extern: 1
intvolume: ' 56'
issue: '3'
month: '08'
page: 500 - 502
publication: Canadian Mathematical Bulletin
publication_status: published
publisher: Unknown
publist_id: '7657'
quality_controlled: 0
status: public
title: The Lang-Weil estimate for cubic hypersurfaces
type: journal_article
volume: 56
year: '2013'
...
---
_id: '2473'
abstract:
- lang: eng
text: 'When a mutation with selective advantage s spreads through a panmictic population,
it may cause two lineages at a linked locus to coalesce; the probability of coalescence
is exp(−2rT), where T∼log(2Ns)/s is the time to fixation, N is the number of haploid
individuals, and r is the recombination rate. Population structure delays fixation,
and so weakens the effect of a selective sweep. However, favourable alleles spread
through a spatially continuous population behind a narrow wavefront; ancestral
lineages are confined at the tip of this front, and so coalesce rapidly. In extremely
dense populations, coalescence is dominated by rare fluctuations ahead of the
front. However, we show that for moderate densities, a simple quasi-deterministic
approximation applies: the rate of coalescence within the front is λ∼2g(η)/(ρℓ),
where ρ is the population density and is the characteristic scale of the wavefront;
g(η) depends only on the strength of random drift, . The net effect of a sweep
on coalescence also depends crucially on whether two lineages are ever both within
the wavefront at the same time: even in the extreme case when coalescence within
the front is instantaneous, the net rate of coalescence may be lower than in a
single panmictic population. Sweeps can also have a substantial impact on the
rate of gene flow. A single lineage will jump to a new location when it is hit
by a sweep, with mean square displacement ; this can be substantial if the species’
range, L, is large, even if the species-wide rate of sweeps per map length, Λ/R,
is small. This effect is half as strong in two dimensions. In contrast, the rate
of coalescence between lineages, at random locations in space and on the genetic
map, is proportional to (c/L)(Λ/R), where c is the wavespeed: thus, on average,
one-dimensional structure is likely to reduce coalescence due to sweeps, relative
to panmixis. In two dimensions, genes must move along the front before they can
coalesce; this process is rapid, being dominated by rare fluctuations. This leads
to a dramatically higher rate of coalescence within the wavefront than if lineages
simply diffused along the front. Nevertheless, the net rate of coalescence due
to a sweep through a two-dimensional population is likely to be lower than it
would be with panmixis.'
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Alison
full_name: Etheridge, Alison
last_name: Etheridge
- first_name: Jerome
full_name: Kelleher, Jerome
last_name: Kelleher
- first_name: Amandine
full_name: Véber, Amandine
last_name: Véber
citation:
ama: Barton NH, Etheridge A, Kelleher J, Véber A. Genetic hitch-hiking in spatially
extended populations. Theoretical Population Biology. 2013;87(8):75-89.
doi:10.1016/j.tpb.2012.12.001
apa: Barton, N. H., Etheridge, A., Kelleher, J., & Véber, A. (2013). Genetic
hitch-hiking in spatially extended populations. Theoretical Population Biology.
Elsevier. https://doi.org/10.1016/j.tpb.2012.12.001
chicago: Barton, Nicholas H, Alison Etheridge, Jerome Kelleher, and Amandine Véber.
“Genetic Hitch-Hiking in Spatially Extended Populations.” Theoretical Population
Biology. Elsevier, 2013. https://doi.org/10.1016/j.tpb.2012.12.001.
ieee: N. H. Barton, A. Etheridge, J. Kelleher, and A. Véber, “Genetic hitch-hiking
in spatially extended populations,” Theoretical Population Biology, vol.
87, no. 8. Elsevier, pp. 75–89, 2013.
ista: Barton NH, Etheridge A, Kelleher J, Véber A. 2013. Genetic hitch-hiking in
spatially extended populations. Theoretical Population Biology. 87(8), 75–89.
mla: Barton, Nicholas H., et al. “Genetic Hitch-Hiking in Spatially Extended Populations.”
Theoretical Population Biology, vol. 87, no. 8, Elsevier, 2013, pp. 75–89,
doi:10.1016/j.tpb.2012.12.001.
short: N.H. Barton, A. Etheridge, J. Kelleher, A. Véber, Theoretical Population
Biology 87 (2013) 75–89.
date_created: 2018-12-11T11:57:52Z
date_published: 2013-01-03T00:00:00Z
date_updated: 2021-01-12T06:57:42Z
day: '03'
ddc:
- '570'
department:
- _id: NiBa
doi: 10.1016/j.tpb.2012.12.001
ec_funded: 1
file:
- access_level: open_access
checksum: 4274ec1f433b838a7d5b941cc9684ca7
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:18:54Z
date_updated: 2020-07-14T12:45:41Z
file_id: '5376'
file_name: IST-2013-118-v1+1_bartonetalRevision.pdf
file_size: 1706282
relation: main_file
file_date_updated: 2020-07-14T12:45:41Z
has_accepted_license: '1'
intvolume: ' 87'
issue: '8'
language:
- iso: eng
month: '01'
oa: 1
oa_version: Submitted Version
page: 75 - 89
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
publication: Theoretical Population Biology
publication_status: published
publisher: Elsevier
publist_id: '4428'
pubrep_id: '118'
quality_controlled: '1'
scopus_import: 1
status: public
title: Genetic hitch-hiking in spatially extended populations
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 87
year: '2013'
...
---
_id: '2478'
abstract:
- lang: eng
text: Despite the pivotal functions of the NMDA receptor (NMDAR) for neural circuit
development and synaptic plasticity, the molecular mechanisms underlying the dynamics
of NMDAR trafficking are poorly understood. The cell adhesion molecule neuroligin-1
(NL1) modifies NMDAR-dependent synaptic transmission and synaptic plasticity,
but it is unclear whether NL1 controls synaptic accumulation or function of the
receptors. Here, we provide evidence that NL1 regulates the abundance of NMDARs
at postsynaptic sites. This function relies on extracellular, NL1 isoform-specific
sequences that facilitate biochemical interactions between NL1 and the NMDAR GluN1
subunit. Our work uncovers NL1 isoform-specific cisinteractions with ionotropic
glutamate receptors as a key mechanism for controlling synaptic properties.
author:
- first_name: Elaine
full_name: Budreck, Elaine C
last_name: Budreck
- first_name: Oh
full_name: Kwon, Oh-Bin
last_name: Kwon
- first_name: Jung
full_name: Jung, Jung-Hoon
last_name: Jung
- first_name: Stéphane
full_name: Baudouin, Stéphane J
last_name: Baudouin
- first_name: Albert
full_name: Thommen, Albert
last_name: Thommen
- first_name: Hye
full_name: Kim, Hye-Sun
last_name: Kim
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Harumi
full_name: Harumi Harada
id: 2E55CDF2-F248-11E8-B48F-1D18A9856A87
last_name: Harada
orcid: 0000-0001-7429-7896
- first_name: Katsuhiko
full_name: Tabuchi, Katsuhiko
last_name: Tabuchi
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Peter
full_name: Scheiffele, Peter
last_name: Scheiffele
- first_name: Joung
full_name: Kim, Joung-Hun
last_name: Kim
citation:
ama: Budreck E, Kwon O, Jung J, et al. Neuroligin-1 controls synaptic abundance
of NMDA-type glutamate receptors through extracellular coupling. PNAS.
2013;110(2):725-730. doi:10.1073/pnas.1214718110
apa: Budreck, E., Kwon, O., Jung, J., Baudouin, S., Thommen, A., Kim, H., … Kim,
J. (2013). Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors
through extracellular coupling. PNAS. National Academy of Sciences. https://doi.org/10.1073/pnas.1214718110
chicago: Budreck, Elaine, Oh Kwon, Jung Jung, Stéphane Baudouin, Albert Thommen,
Hye Kim, Yugo Fukazawa, et al. “Neuroligin-1 Controls Synaptic Abundance of NMDA-Type
Glutamate Receptors through Extracellular Coupling.” PNAS. National Academy
of Sciences, 2013. https://doi.org/10.1073/pnas.1214718110.
ieee: E. Budreck et al., “Neuroligin-1 controls synaptic abundance of NMDA-type
glutamate receptors through extracellular coupling,” PNAS, vol. 110, no.
2. National Academy of Sciences, pp. 725–730, 2013.
ista: Budreck E, Kwon O, Jung J, Baudouin S, Thommen A, Kim H, Fukazawa Y, Harada
H, Tabuchi K, Shigemoto R, Scheiffele P, Kim J. 2013. Neuroligin-1 controls synaptic
abundance of NMDA-type glutamate receptors through extracellular coupling. PNAS.
110(2), 725–730.
mla: Budreck, Elaine, et al. “Neuroligin-1 Controls Synaptic Abundance of NMDA-Type
Glutamate Receptors through Extracellular Coupling.” PNAS, vol. 110, no.
2, National Academy of Sciences, 2013, pp. 725–30, doi:10.1073/pnas.1214718110.
short: E. Budreck, O. Kwon, J. Jung, S. Baudouin, A. Thommen, H. Kim, Y. Fukazawa,
H. Harada, K. Tabuchi, R. Shigemoto, P. Scheiffele, J. Kim, PNAS 110 (2013) 725–730.
date_created: 2018-12-11T11:57:54Z
date_published: 2013-01-08T00:00:00Z
date_updated: 2021-01-12T06:57:43Z
day: '08'
doi: 10.1073/pnas.1214718110
extern: 1
intvolume: ' 110'
issue: '2'
month: '01'
page: 725 - 730
publication: PNAS
publication_status: published
publisher: National Academy of Sciences
publist_id: '4423'
quality_controlled: 0
status: public
title: Neuroligin-1 controls synaptic abundance of NMDA-type glutamate receptors through
extracellular coupling
type: journal_article
volume: 110
year: '2013'
...
---
_id: '250'
abstract:
- lang: eng
text: Châtelet surfaces provide a rich source of geometrically rational surfaces
that do not always satisfy the Hasse principle. Restricting attention to a special
class of Châtelet surfaces, we investigate the frequency that such counter-examples
arise over the rational numbers.
acknowledgement: While working on this paper, the first author was supported by an
IUF Junior and ANR while the second author was supported by ERC grant 306457.
author:
- first_name: Régis
full_name: de la Bretèche, Régis
last_name: De La Bretèche
- first_name: Timothy D
full_name: Timothy Browning
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
citation:
ama: De La Bretèche R, Browning TD. Density of Châtelet surfaces failing the Hasse
principle. Proceedings of the London Mathematical Society. 2013;108(4):1030-1078.
doi:10.1112/plms/pdt060
apa: De La Bretèche, R., & Browning, T. D. (2013). Density of Châtelet surfaces
failing the Hasse principle. Proceedings of the London Mathematical Society.
Oxford University Press. https://doi.org/10.1112/plms/pdt060
chicago: De La Bretèche, Régis, and Timothy D Browning. “Density of Châtelet Surfaces
Failing the Hasse Principle.” Proceedings of the London Mathematical Society.
Oxford University Press, 2013. https://doi.org/10.1112/plms/pdt060.
ieee: R. De La Bretèche and T. D. Browning, “Density of Châtelet surfaces failing
the Hasse principle,” Proceedings of the London Mathematical Society, vol.
108, no. 4. Oxford University Press, pp. 1030–1078, 2013.
ista: De La Bretèche R, Browning TD. 2013. Density of Châtelet surfaces failing
the Hasse principle. Proceedings of the London Mathematical Society. 108(4), 1030–1078.
mla: De La Bretèche, Régis, and Timothy D. Browning. “Density of Châtelet Surfaces
Failing the Hasse Principle.” Proceedings of the London Mathematical Society,
vol. 108, no. 4, Oxford University Press, 2013, pp. 1030–78, doi:10.1112/plms/pdt060.
short: R. De La Bretèche, T.D. Browning, Proceedings of the London Mathematical
Society 108 (2013) 1030–1078.
date_created: 2018-12-11T11:45:26Z
date_published: 2013-11-29T00:00:00Z
date_updated: 2021-01-12T06:57:51Z
day: '29'
doi: 10.1112/plms/pdt060
extern: 1
intvolume: ' 108'
issue: '4'
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1210.4010
month: '11'
oa: 1
page: 1030 - 1078
publication: Proceedings of the London Mathematical Society
publication_status: published
publisher: Oxford University Press
publist_id: '7652'
quality_controlled: 0
status: public
title: Density of Châtelet surfaces failing the Hasse principle
type: journal_article
volume: 108
year: '2013'
...
---
_id: '251'
abstract:
- lang: eng
text: We study the density of varieties in a certain family which do not satisfy
the Hasse principle. This work relies on results recently obtained by Colliot-Thélène
[3].
author:
- first_name: Régis
full_name: de la Bretèche, Régis
last_name: De La Bretèche
- first_name: Timothy D
full_name: Timothy Browning
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
citation:
ama: De La Bretèche R, Browning TD. Counter examples to the Hasse principle among
certain coflasque tori. Journal de Theorie des Nombres de Bordeaux. 2013;26(1):25-44.
doi:10.5802/jtnb.857
apa: De La Bretèche, R., & Browning, T. D. (2013). Counter examples to the Hasse
principle among certain coflasque tori. Journal de Theorie Des Nombres de Bordeaux.
Universite de Bordeaux I. https://doi.org/10.5802/jtnb.857
chicago: De La Bretèche, Régis, and Timothy D Browning. “Counter Examples to the
Hasse Principle among Certain Coflasque Tori.” Journal de Theorie Des Nombres
de Bordeaux. Universite de Bordeaux I, 2013. https://doi.org/10.5802/jtnb.857.
ieee: R. De La Bretèche and T. D. Browning, “Counter examples to the Hasse principle
among certain coflasque tori,” Journal de Theorie des Nombres de Bordeaux,
vol. 26, no. 1. Universite de Bordeaux I, pp. 25–44, 2013.
ista: De La Bretèche R, Browning TD. 2013. Counter examples to the Hasse principle
among certain coflasque tori. Journal de Theorie des Nombres de Bordeaux. 26(1),
25–44.
mla: De La Bretèche, Régis, and Timothy D. Browning. “Counter Examples to the Hasse
Principle among Certain Coflasque Tori.” Journal de Theorie Des Nombres de
Bordeaux, vol. 26, no. 1, Universite de Bordeaux I, 2013, pp. 25–44, doi:10.5802/jtnb.857.
short: R. De La Bretèche, T.D. Browning, Journal de Theorie Des Nombres de Bordeaux
26 (2013) 25–44.
date_created: 2018-12-11T11:45:26Z
date_published: 2013-05-14T00:00:00Z
date_updated: 2021-01-12T06:57:55Z
day: '14'
doi: 10.5802/jtnb.857
extern: 1
intvolume: ' 26'
issue: '1'
month: '05'
page: 25 - 44
publication: Journal de Theorie des Nombres de Bordeaux
publication_status: published
publisher: Universite de Bordeaux I
publist_id: '7651'
quality_controlled: 0
status: public
title: Counter examples to the Hasse principle among certain coflasque tori
type: journal_article
volume: 26
year: '2013'
...
---
_id: '2517'
abstract:
- lang: eng
text: 'Traditional formal methods are based on a Boolean satisfaction notion: a
reactive system satisfies, or not, a given specification. We generalize formal
methods to also address the quality of systems. As an adequate specification formalism
we introduce the linear temporal logic LTL[F]. The satisfaction value of an LTL[F]
formula is a number between 0 and 1, describing the quality of the satisfaction.
The logic generalizes traditional LTL by augmenting it with a (parameterized)
set F of arbitrary functions over the interval [0,1]. For example, F may contain
the maximum or minimum between the satisfaction values of subformulas, their product,
and their average. The classical decision problems in formal methods, such as
satisfiability, model checking, and synthesis, are generalized to search and optimization
problems in the quantitative setting. For example, model checking asks for the
quality in which a specification is satisfied, and synthesis returns a system
satisfying the specification with the highest quality. Reasoning about quality
gives rise to other natural questions, like the distance between specifications.
We formalize these basic questions and study them for LTL[F]. By extending the
automata-theoretic approach for LTL to a setting that takes quality into an account,
we are able to solve the above problems and show that reasoning about LTL[F] has
roughly the same complexity as reasoning about traditional LTL.'
acknowledgement: 'ERC Grant QUALITY. '
alternative_title:
- LNCS
article_processing_charge: No
author:
- first_name: Shaull
full_name: Almagor, Shaull
last_name: Almagor
- first_name: Udi
full_name: Boker, Udi
id: 31E297B6-F248-11E8-B48F-1D18A9856A87
last_name: Boker
- first_name: Orna
full_name: Kupferman, Orna
last_name: Kupferman
citation:
ama: Almagor S, Boker U, Kupferman O. Formalizing and reasoning about quality. 2013;7966(Part
2):15-27. doi:10.1007/978-3-642-39212-2_3
apa: 'Almagor, S., Boker, U., & Kupferman, O. (2013). Formalizing and reasoning
about quality. Presented at the ICALP: Automata, Languages and Programming, Riga,
Latvia: Springer. https://doi.org/10.1007/978-3-642-39212-2_3'
chicago: Almagor, Shaull, Udi Boker, and Orna Kupferman. “Formalizing and Reasoning
about Quality.” Lecture Notes in Computer Science. Springer, 2013. https://doi.org/10.1007/978-3-642-39212-2_3.
ieee: S. Almagor, U. Boker, and O. Kupferman, “Formalizing and reasoning about quality,”
vol. 7966, no. Part 2. Springer, pp. 15–27, 2013.
ista: Almagor S, Boker U, Kupferman O. 2013. Formalizing and reasoning about quality.
7966(Part 2), 15–27.
mla: Almagor, Shaull, et al. Formalizing and Reasoning about Quality. Vol.
7966, no. Part 2, Springer, 2013, pp. 15–27, doi:10.1007/978-3-642-39212-2_3.
short: S. Almagor, U. Boker, O. Kupferman, 7966 (2013) 15–27.
conference:
end_date: 2013-07-12
location: Riga, Latvia
name: 'ICALP: Automata, Languages and Programming'
start_date: 2013-07-08
date_created: 2018-12-11T11:58:08Z
date_published: 2013-07-01T00:00:00Z
date_updated: 2020-08-11T10:09:47Z
day: '01'
ddc:
- '000'
department:
- _id: ToHe
doi: 10.1007/978-3-642-39212-2_3
ec_funded: 1
file:
- access_level: open_access
checksum: 85afbf6c18a2c7e377c52c9410e2d824
content_type: application/pdf
creator: dernst
date_created: 2020-05-15T11:16:12Z
date_updated: 2020-07-14T12:45:42Z
file_id: '7860'
file_name: 2013_ICALP_Almagor.pdf
file_size: 363031
relation: main_file
file_date_updated: 2020-07-14T12:45:42Z
has_accepted_license: '1'
intvolume: ' 7966'
issue: Part 2
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
page: 15 - 27
project:
- _id: 25832EC2-B435-11E9-9278-68D0E5697425
call_identifier: FWF
grant_number: S 11407_N23
name: Rigorous Systems Engineering
- _id: 25EE3708-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '267989'
name: Quantitative Reactive Modeling
publication_status: published
publisher: Springer
publist_id: '4384'
quality_controlled: '1'
scopus_import: 1
series_title: Lecture Notes in Computer Science
status: public
title: Formalizing and reasoning about quality
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 7966
year: '2013'
...
---
_id: '2518'
abstract:
- lang: eng
text: A class of valued constraint satisfaction problems (VCSPs) is characterised
by a valued constraint language, a fixed set of cost functions on a finite domain.
An instance of the problem is specified by a sum of cost functions from the language
with the goal to minimise the sum. We study which classes of finite-valued languages
can be solved exactly by the basic linear programming relaxation (BLP). Thapper
and Živný showed [20] that if BLP solves the language then the language admits
a binary commutative fractional polymorphism. We prove that the converse is also
true. This leads to a necessary and a sufficient condition which can be checked
in polynomial time for a given language. In contrast, the previous necessary and
sufficient condition due to [20] involved infinitely many inequalities. More recently,
Thapper and Živný [21] showed (using, in particular, a technique introduced in
this paper) that core languages that do not satisfy our condition are NP-hard.
Taken together, these results imply that a finite-valued language can either be
solved using Linear Programming or is NP-hard.
alternative_title:
- LNCS
author:
- first_name: Vladimir
full_name: Kolmogorov, Vladimir
id: 3D50B0BA-F248-11E8-B48F-1D18A9856A87
last_name: Kolmogorov
citation:
ama: 'Kolmogorov V. The power of linear programming for finite-valued CSPs: A constructive
characterization. In: Vol 7965. Springer; 2013:625-636. doi:10.1007/978-3-642-39206-1_53'
apa: 'Kolmogorov, V. (2013). The power of linear programming for finite-valued CSPs:
A constructive characterization (Vol. 7965, pp. 625–636). Presented at the ICALP:
Automata, Languages and Programming, Riga, Latvia: Springer. https://doi.org/10.1007/978-3-642-39206-1_53'
chicago: 'Kolmogorov, Vladimir. “The Power of Linear Programming for Finite-Valued
CSPs: A Constructive Characterization,” 7965:625–36. Springer, 2013. https://doi.org/10.1007/978-3-642-39206-1_53.'
ieee: 'V. Kolmogorov, “The power of linear programming for finite-valued CSPs: A
constructive characterization,” presented at the ICALP: Automata, Languages and
Programming, Riga, Latvia, 2013, vol. 7965, no. 1, pp. 625–636.'
ista: 'Kolmogorov V. 2013. The power of linear programming for finite-valued CSPs:
A constructive characterization. ICALP: Automata, Languages and Programming, LNCS,
vol. 7965, 625–636.'
mla: 'Kolmogorov, Vladimir. The Power of Linear Programming for Finite-Valued
CSPs: A Constructive Characterization. Vol. 7965, no. 1, Springer, 2013, pp.
625–36, doi:10.1007/978-3-642-39206-1_53.'
short: V. Kolmogorov, in:, Springer, 2013, pp. 625–636.
conference:
end_date: 2013-07-12
location: Riga, Latvia
name: 'ICALP: Automata, Languages and Programming'
start_date: 2013-07-08
date_created: 2018-12-11T11:58:08Z
date_published: 2013-07-01T00:00:00Z
date_updated: 2023-02-23T10:35:42Z
day: '01'
department:
- _id: VlKo
doi: 10.1007/978-3-642-39206-1_53
external_id:
arxiv:
- '1207.7213'
intvolume: ' 7965'
issue: '1'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1207.7213
month: '07'
oa: 1
oa_version: Preprint
page: 625 - 636
publication_status: published
publisher: Springer
publist_id: '4383'
quality_controlled: '1'
related_material:
record:
- id: '2271'
relation: later_version
status: public
scopus_import: 1
status: public
title: 'The power of linear programming for finite-valued CSPs: A constructive characterization'
type: conference
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 7965
year: '2013'
...
---
_id: '2516'
abstract:
- lang: eng
text: 'We study the problem of object recognition for categories for which we have
no training examples, a task also called zero-data or zero-shot learning. This
situation has hardly been studied in computer vision research, even though it
occurs frequently: the world contains tens of thousands of different object classes
and for only few of them image collections have been formed and suitably annotated.
To tackle the problem we introduce attribute-based classification: objects are
identified based on a high-level description that is phrased in terms of semantic
attributes, such as the object''s color or shape. Because the identification of
each such property transcends the specific learning task at hand, the attribute
classifiers can be pre-learned independently, e.g. from existing image datasets
unrelated to the current task. Afterwards, new classes can be detected based on
their attribute representation, without the need for a new training phase. In
this paper we also introduce a new dataset, Animals with Attributes, of over 30,000
images of 50 animal classes, annotated with 85 semantic attributes. Extensive
experiments on this and two more datasets show that attribute-based classification
indeed is able to categorize images without access to any training images of the
target classes.'
author:
- first_name: Christoph
full_name: Lampert, Christoph
id: 40C20FD2-F248-11E8-B48F-1D18A9856A87
last_name: Lampert
orcid: 0000-0001-8622-7887
- first_name: Hannes
full_name: Nickisch, Hannes
last_name: Nickisch
- first_name: Stefan
full_name: Harmeling, Stefan
last_name: Harmeling
citation:
ama: Lampert C, Nickisch H, Harmeling S. Attribute-based classification for zero-shot
learning of object categories. IEEE Transactions on Pattern Analysis and Machine
Intelligence. 2013;36(3):453-465. doi:10.1109/TPAMI.2013.140
apa: Lampert, C., Nickisch, H., & Harmeling, S. (2013). Attribute-based classification
for zero-shot learning of object categories. IEEE Transactions on Pattern Analysis
and Machine Intelligence. IEEE. https://doi.org/10.1109/TPAMI.2013.140
chicago: Lampert, Christoph, Hannes Nickisch, and Stefan Harmeling. “Attribute-Based
Classification for Zero-Shot Learning of Object Categories.” IEEE Transactions
on Pattern Analysis and Machine Intelligence. IEEE, 2013. https://doi.org/10.1109/TPAMI.2013.140.
ieee: C. Lampert, H. Nickisch, and S. Harmeling, “Attribute-based classification
for zero-shot learning of object categories,” IEEE Transactions on Pattern
Analysis and Machine Intelligence, vol. 36, no. 3. IEEE, pp. 453–465, 2013.
ista: Lampert C, Nickisch H, Harmeling S. 2013. Attribute-based classification for
zero-shot learning of object categories. IEEE Transactions on Pattern Analysis
and Machine Intelligence. 36(3), 453–465.
mla: Lampert, Christoph, et al. “Attribute-Based Classification for Zero-Shot Learning
of Object Categories.” IEEE Transactions on Pattern Analysis and Machine Intelligence,
vol. 36, no. 3, IEEE, 2013, pp. 453–65, doi:10.1109/TPAMI.2013.140.
short: C. Lampert, H. Nickisch, S. Harmeling, IEEE Transactions on Pattern Analysis
and Machine Intelligence 36 (2013) 453–465.
date_created: 2018-12-11T11:58:08Z
date_published: 2013-07-30T00:00:00Z
date_updated: 2021-01-12T06:57:58Z
day: '30'
department:
- _id: ChLa
doi: 10.1109/TPAMI.2013.140
intvolume: ' 36'
issue: '3'
language:
- iso: eng
month: '07'
oa_version: None
page: 453 - 465
publication: IEEE Transactions on Pattern Analysis and Machine Intelligence
publication_status: published
publisher: IEEE
publist_id: '4385'
quality_controlled: '1'
scopus_import: 1
status: public
title: Attribute-based classification for zero-shot learning of object categories
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 36
year: '2013'
...
---
_id: '2520'
abstract:
- lang: eng
text: "We propose a probabilistic model to infer supervised latent variables in\r\nthe
Hamming space from observed data. Our model allows simultaneous\r\ninference of
the number of binary latent variables, and their values. The\r\nlatent variables
preserve neighbourhood structure of the data in a sense\r\nthat objects in the
same semantic concept have similar latent values, and\r\nobjects in different
concepts have dissimilar latent values. We formulate\r\nthe supervised infinite
latent variable problem based on an intuitive\r\nprinciple of pulling objects
together if they are of the same type, and\r\npushing them apart if they are not.
We then combine this principle with a\r\nflexible Indian Buffet Process prior
on the latent variables. We show that\r\nthe inferred supervised latent variables
can be directly used to perform a\r\nnearest neighbour search for the purpose
of retrieval. We introduce a new\r\napplication of dynamically extending hash
codes, and show how to\r\neffectively couple the structure of the hash codes with
continuously\r\ngrowing structure of the neighbourhood preserving infinite latent
feature\r\nspace."
author:
- first_name: Novi
full_name: Quadrianto, Novi
last_name: Quadrianto
- first_name: Viktoriia
full_name: Sharmanska, Viktoriia
id: 2EA6D09E-F248-11E8-B48F-1D18A9856A87
last_name: Sharmanska
orcid: 0000-0003-0192-9308
- first_name: David
full_name: Knowles, David
last_name: Knowles
- first_name: Zoubin
full_name: Ghahramani, Zoubin
last_name: Ghahramani
citation:
ama: 'Quadrianto N, Sharmanska V, Knowles D, Ghahramani Z. The supervised IBP: Neighbourhood
preserving infinite latent feature models. In: Proceedings of the 29th Conference
Uncertainty in Artificial Intelligence. AUAI Press; 2013:527-536.'
apa: 'Quadrianto, N., Sharmanska, V., Knowles, D., & Ghahramani, Z. (2013).
The supervised IBP: Neighbourhood preserving infinite latent feature models. In
Proceedings of the 29th conference uncertainty in Artificial Intelligence
(pp. 527–536). Bellevue, WA, United States: AUAI Press.'
chicago: 'Quadrianto, Novi, Viktoriia Sharmanska, David Knowles, and Zoubin Ghahramani.
“The Supervised IBP: Neighbourhood Preserving Infinite Latent Feature Models.”
In Proceedings of the 29th Conference Uncertainty in Artificial Intelligence,
527–36. AUAI Press, 2013.'
ieee: 'N. Quadrianto, V. Sharmanska, D. Knowles, and Z. Ghahramani, “The supervised
IBP: Neighbourhood preserving infinite latent feature models,” in Proceedings
of the 29th conference uncertainty in Artificial Intelligence, Bellevue, WA,
United States, 2013, pp. 527–536.'
ista: 'Quadrianto N, Sharmanska V, Knowles D, Ghahramani Z. 2013. The supervised
IBP: Neighbourhood preserving infinite latent feature models. Proceedings of the
29th conference uncertainty in Artificial Intelligence. UAI: Uncertainty in Artificial
Intelligence, 527–536.'
mla: 'Quadrianto, Novi, et al. “The Supervised IBP: Neighbourhood Preserving Infinite
Latent Feature Models.” Proceedings of the 29th Conference Uncertainty in Artificial
Intelligence, AUAI Press, 2013, pp. 527–36.'
short: N. Quadrianto, V. Sharmanska, D. Knowles, Z. Ghahramani, in:, Proceedings
of the 29th Conference Uncertainty in Artificial Intelligence, AUAI Press, 2013,
pp. 527–536.
conference:
end_date: 2013-07-15
location: Bellevue, WA, United States
name: 'UAI: Uncertainty in Artificial Intelligence'
start_date: 2013-07-11
date_created: 2018-12-11T11:58:09Z
date_published: 2013-07-11T00:00:00Z
date_updated: 2023-02-23T10:46:36Z
day: '11'
ddc:
- '000'
department:
- _id: ChLa
file:
- access_level: open_access
checksum: 325f20c4b926bd74d39006b97df572bd
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:16Z
date_updated: 2020-07-14T12:45:42Z
file_id: '5134'
file_name: IST-2013-137-v1+1_QuaShaKnoGha13.pdf
file_size: 1117100
relation: main_file
file_date_updated: 2020-07-14T12:45:42Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
page: 527 - 536
publication: Proceedings of the 29th conference uncertainty in Artificial Intelligence
publication_identifier:
isbn:
- '9780974903996'
publication_status: published
publisher: AUAI Press
publist_id: '4381'
pubrep_id: '137'
quality_controlled: '1'
scopus_import: 1
status: public
title: 'The supervised IBP: Neighbourhood preserving infinite latent feature models'
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2013'
...
---
_id: '253'
author:
- first_name: Timothy D
full_name: Timothy Browning
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
citation:
ama: 'Browning TD. Counting rational points on cubic hypersurfaces: Corrigendum.
Mathematika. 2013;60(1):101-107. doi:10.1112/S0025579313000132'
apa: 'Browning, T. D. (2013). Counting rational points on cubic hypersurfaces: Corrigendum.
Mathematika. Unknown. https://doi.org/10.1112/S0025579313000132'
chicago: 'Browning, Timothy D. “Counting Rational Points on Cubic Hypersurfaces:
Corrigendum.” Mathematika. Unknown, 2013. https://doi.org/10.1112/S0025579313000132.'
ieee: 'T. D. Browning, “Counting rational points on cubic hypersurfaces: Corrigendum,”
Mathematika, vol. 60, no. 1. Unknown, pp. 101–107, 2013.'
ista: 'Browning TD. 2013. Counting rational points on cubic hypersurfaces: Corrigendum.
Mathematika. 60(1), 101–107.'
mla: 'Browning, Timothy D. “Counting Rational Points on Cubic Hypersurfaces: Corrigendum.”
Mathematika, vol. 60, no. 1, Unknown, 2013, pp. 101–07, doi:10.1112/S0025579313000132.'
short: T.D. Browning, Mathematika 60 (2013) 101–107.
date_created: 2018-12-11T11:45:27Z
date_published: 2013-09-06T00:00:00Z
date_updated: 2021-01-12T06:58:03Z
day: '06'
doi: 10.1112/S0025579313000132
extern: 1
intvolume: ' 60'
issue: '1'
month: '09'
page: 101 - 107
publication: Mathematika
publication_status: published
publisher: Unknown
publist_id: '7649'
quality_controlled: 0
status: public
title: 'Counting rational points on cubic hypersurfaces: Corrigendum'
type: journal_article
volume: 60
year: '2013'
...
---
_id: '2692'
abstract:
- lang: eng
text: The group III metabotropic glutamate (mGlu) receptors mGlu7 and mGlu8 are
receiving increased attention as potential novel therapeutic targets for anxiety
disorders. The effects mediated by these receptors appear to result from a complex
interplay of facilitatory and inhibitory actions at different brain sites in the
anxiety/fear circuits. To better understand the effect of mGlu7 and mGlu8 receptors
on extinction of contextual fear and their critical sites of action in the fear
networks, we focused on the amygdala. Direct injection into the basolateral complex
of the amygdala of the mGlu7 receptor agonist AMN082 facilitated extinction, whereas
the mGlu8 receptor agonist (S)-3,4-DCPG sustained freezing during the extinction
acquisition trial. We also determined at the ultrastructural level the synaptic
distribution of these receptors in the basal nucleus (BA) and intercalated cell
clusters (ITCs) of the amygdala. Both areas are thought to exert key roles in
fear extinction. We demonstrate that mGlu7 and mGlu8 receptors are located in
different presynaptic terminals forming both asymmetric and symmetric synapses,
and that they preferentially target neurons expressing mGlu1α receptors mostly
located around ITCs. In addition we show that mGlu7 and mGlu8 receptors were segregated
to different inputs to a significant extent. In particular, mGlu7a receptors were
primarily onto glutamatergic afferents arising from the BA or midline thalamic
nuclei, but not the medial prefrontal cortex (mPFC), as revealed by combined anterograde
tracing and pre-embedding electron microscopy. On the other hand, mGlu8a showed
a more restricted distribution in the BA and appeared absent from thalamic, mPFC
and intrinsic inputs. This segregation of mGlu7 and mGlu8 receptors in different
neuronal pathways of the fear circuit might explain the distinct effects on fear
extinction training observed with mGlu7 and mGlu8 receptor agonists.
author:
- first_name: Alice
full_name: Dobi, Alice
last_name: Dobi
- first_name: Simone
full_name: Sartori, Simone B
last_name: Sartori
- first_name: Daniela
full_name: Busti, Daniela
last_name: Busti
- first_name: Herman
full_name: Van Der Putten, Herman V
last_name: Van Der Putten
- first_name: Nicolas
full_name: Singewald, Nicolas
last_name: Singewald
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Francesco
full_name: Ferraguti, Francesco
last_name: Ferraguti
citation:
ama: Dobi A, Sartori S, Busti D, et al. Neural substrates for the distinct effects
of presynaptic group III metabotropic glutamate receptors on extinction of contextual
fear conditioning in mice. Neuropharmacology. 2013;66:274-289. doi:10.1016/j.neuropharm.2012.05.025
apa: Dobi, A., Sartori, S., Busti, D., Van Der Putten, H., Singewald, N., Shigemoto,
R., & Ferraguti, F. (2013). Neural substrates for the distinct effects of
presynaptic group III metabotropic glutamate receptors on extinction of contextual
fear conditioning in mice. Neuropharmacology. Elsevier. https://doi.org/10.1016/j.neuropharm.2012.05.025
chicago: Dobi, Alice, Simone Sartori, Daniela Busti, Herman Van Der Putten, Nicolas
Singewald, Ryuichi Shigemoto, and Francesco Ferraguti. “Neural Substrates for
the Distinct Effects of Presynaptic Group III Metabotropic Glutamate Receptors
on Extinction of Contextual Fear Conditioning in Mice.” Neuropharmacology.
Elsevier, 2013. https://doi.org/10.1016/j.neuropharm.2012.05.025.
ieee: A. Dobi et al., “Neural substrates for the distinct effects of presynaptic
group III metabotropic glutamate receptors on extinction of contextual fear conditioning
in mice,” Neuropharmacology, vol. 66. Elsevier, pp. 274–289, 2013.
ista: Dobi A, Sartori S, Busti D, Van Der Putten H, Singewald N, Shigemoto R, Ferraguti
F. 2013. Neural substrates for the distinct effects of presynaptic group III metabotropic
glutamate receptors on extinction of contextual fear conditioning in mice. Neuropharmacology.
66, 274–289.
mla: Dobi, Alice, et al. “Neural Substrates for the Distinct Effects of Presynaptic
Group III Metabotropic Glutamate Receptors on Extinction of Contextual Fear Conditioning
in Mice.” Neuropharmacology, vol. 66, Elsevier, 2013, pp. 274–89, doi:10.1016/j.neuropharm.2012.05.025.
short: A. Dobi, S. Sartori, D. Busti, H. Van Der Putten, N. Singewald, R. Shigemoto,
F. Ferraguti, Neuropharmacology 66 (2013) 274–289.
date_created: 2018-12-11T11:59:06Z
date_published: 2013-03-01T00:00:00Z
date_updated: 2021-01-12T06:59:05Z
day: '01'
doi: 10.1016/j.neuropharm.2012.05.025
extern: 1
intvolume: ' 66'
month: '03'
page: 274 - 289
publication: Neuropharmacology
publication_status: published
publisher: Elsevier
publist_id: '4205'
quality_controlled: 0
status: public
title: Neural substrates for the distinct effects of presynaptic group III metabotropic
glutamate receptors on extinction of contextual fear conditioning in mice
type: journal_article
volume: 66
year: '2013'
...
---
_id: '2691'
abstract:
- lang: eng
text: P/Q-type voltage-dependent calcium channels play key roles in transmitter
release, integration of dendritic signals, generation of dendritic spikes, and
gene expression. High intracellular calcium concentration transient produced by
these channels is restricted to tens to hundreds of nanometers from the channels.
Therefore, precise localization of these channels along the plasma membrane was
long sought to decipher how each neuronal cell function is controlled. Here, we
analyzed the distribution of Cav2.1 subunit of the P/Q-type channel using highly
sensitive SDS-digested freeze-fracture replica labeling in the rat cerebellar
Purkinje cells. The labeling efficiency was such that the number of immunogold
particles in each parallel fiber active zone was comparable to that of functional
channels calculated from previous reports. Two distinct patterns of Cav2.1 distribution,
scattered and clustered, were found in Purkinje cells. The scattered Cav2.1 had
a somatodendritic gradient with the density of immunogold particles increasing
2.5-fold from soma to distal dendrites. The other population with 74-fold higher
density than the scattered particles was found within clusters of intramembrane
particles on the P-face of soma and primary dendrites. Both populations of Cav2.1
were found as early as P3 and increased in the second postnatal week to a mature
level. Using double immunogold labeling, we found that virtually all of the Cav2.1
clusters were colocalized with two types of calcium-activated potassium channels,
BK and SK2, with the nearest neighbor distance of 40∼nm. Calcium nanodomain created
by the opening of Cav2.1 channels likely activates the two channels that limit
the extent of depolarization.
author:
- first_name: Dwi
full_name: Indriati, Dwi Wahyu
last_name: Indriati
- first_name: Naomi
full_name: Kamasawa, Naomi
last_name: Kamasawa
- first_name: Ko
full_name: Matsui, Ko
last_name: Matsui
- first_name: Andrea
full_name: Meredith, Andrea L
last_name: Meredith
- first_name: Masahiko
full_name: Watanabe, Masahiko
last_name: Watanabe
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
citation:
ama: 'Indriati D, Kamasawa N, Matsui K, Meredith A, Watanabe M, Shigemoto R. Quantitative
localization of Cav2.1 (P/Q-Type) voltage-dependent calcium channels in Purkinje
cells: Somatodendritic gradient and distinct somatic coclustering with calcium-activated
potassium channels. Journal of Neuroscience. 2013;33(8):3668-3678. doi:10.1523/JNEUROSCI.2921-12.2013'
apa: 'Indriati, D., Kamasawa, N., Matsui, K., Meredith, A., Watanabe, M., &
Shigemoto, R. (2013). Quantitative localization of Cav2.1 (P/Q-Type) voltage-dependent
calcium channels in Purkinje cells: Somatodendritic gradient and distinct somatic
coclustering with calcium-activated potassium channels. Journal of Neuroscience.
Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.2921-12.2013'
chicago: 'Indriati, Dwi, Naomi Kamasawa, Ko Matsui, Andrea Meredith, Masahiko Watanabe,
and Ryuichi Shigemoto. “Quantitative Localization of Cav2.1 (P/Q-Type) Voltage-Dependent
Calcium Channels in Purkinje Cells: Somatodendritic Gradient and Distinct Somatic
Coclustering with Calcium-Activated Potassium Channels.” Journal of Neuroscience.
Society for Neuroscience, 2013. https://doi.org/10.1523/JNEUROSCI.2921-12.2013.'
ieee: 'D. Indriati, N. Kamasawa, K. Matsui, A. Meredith, M. Watanabe, and R. Shigemoto,
“Quantitative localization of Cav2.1 (P/Q-Type) voltage-dependent calcium channels
in Purkinje cells: Somatodendritic gradient and distinct somatic coclustering
with calcium-activated potassium channels,” Journal of Neuroscience, vol.
33, no. 8. Society for Neuroscience, pp. 3668–3678, 2013.'
ista: 'Indriati D, Kamasawa N, Matsui K, Meredith A, Watanabe M, Shigemoto R. 2013.
Quantitative localization of Cav2.1 (P/Q-Type) voltage-dependent calcium channels
in Purkinje cells: Somatodendritic gradient and distinct somatic coclustering
with calcium-activated potassium channels. Journal of Neuroscience. 33(8), 3668–3678.'
mla: 'Indriati, Dwi, et al. “Quantitative Localization of Cav2.1 (P/Q-Type) Voltage-Dependent
Calcium Channels in Purkinje Cells: Somatodendritic Gradient and Distinct Somatic
Coclustering with Calcium-Activated Potassium Channels.” Journal of Neuroscience,
vol. 33, no. 8, Society for Neuroscience, 2013, pp. 3668–78, doi:10.1523/JNEUROSCI.2921-12.2013.'
short: D. Indriati, N. Kamasawa, K. Matsui, A. Meredith, M. Watanabe, R. Shigemoto,
Journal of Neuroscience 33 (2013) 3668–3678.
date_created: 2018-12-11T11:59:05Z
date_published: 2013-02-20T00:00:00Z
date_updated: 2021-01-12T06:59:05Z
day: '20'
doi: 10.1523/JNEUROSCI.2921-12.2013
extern: 1
intvolume: ' 33'
issue: '8'
month: '02'
page: 3668 - 3678
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '4206'
quality_controlled: 0
status: public
title: 'Quantitative localization of Cav2.1 (P/Q-Type) voltage-dependent calcium channels
in Purkinje cells: Somatodendritic gradient and distinct somatic coclustering with
calcium-activated potassium channels'
type: journal_article
volume: 33
year: '2013'
...
---
_id: '2690'
abstract:
- lang: eng
text: Establishing the spatiotemporal concentration profile of neurotransmitter
following synaptic vesicular release is essential for our understanding of inter-neuronal
communication. Such profile is a determinant of synaptic strength, short-term
plasticity and inter-synaptic crosstalk. Synaptically released glutamate has been
suggested to reach a few millimolar in concentration and last for <1 ms. The
synaptic cleft is often conceived as a single concentration compartment, whereas
a huge gradient likely exists. Modelling studies have attempted to describe this
gradient, but two key parameters, the number of glutamate in a vesicle (NGlu)
and its diffusion coefficient (DGlu) in the extracellular space, remained unresolved.
To determine this profile, the rat calyx of Held synapse at postnatal day 12-16
was studied where diffusion of glutamate occurs two-dimensionally and where quantification
of AMPA receptor distribution on individual postsynaptic specialization on medial
nucleus of the trapezoid body principal cells is possible using SDS-digested freeze-fracture
replica labelling. To assess the performance of these receptors as glutamate sensors,
a kinetic model of the receptors was constructed from outside-out patch recordings.
From here, we simulated synaptic responses and compared them with the EPSC recordings.
Combinations of NGlu and DGlu with an optimum of 7000 and 0.3 μm2 ms-1 reproduced
the data, suggesting slow diffusion. Further simulations showed that a single
vesicle does not saturate the synaptic receptors, and that glutamate spillover
does not affect the conductance amplitude at this synapse. Using the estimated
profile, we also evaluated how the number of multiple vesicle releases at individual
active zones affects the amplitude of postsynaptic signals.
author:
- first_name: Timotheus
full_name: Budisantoso, Timotheus
last_name: Budisantoso
- first_name: Harumi
full_name: Harumi Harada
id: 2E55CDF2-F248-11E8-B48F-1D18A9856A87
last_name: Harada
orcid: 0000-0001-7429-7896
- first_name: Naomi
full_name: Kamasawa, Naomi
last_name: Kamasawa
- first_name: Yugo
full_name: Fukazawa, Yugo
last_name: Fukazawa
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Ko
full_name: Matsui, Ko
last_name: Matsui
citation:
ama: Budisantoso T, Harada H, Kamasawa N, Fukazawa Y, Shigemoto R, Matsui K. Evaluation
of glutamate concentration transient in the synaptic cleft of the rat calyx of
Held. Journal of Physiology. 2013;591(1):219-239. doi:10.1113/jphysiol.2012.241398
apa: Budisantoso, T., Harada, H., Kamasawa, N., Fukazawa, Y., Shigemoto, R., &
Matsui, K. (2013). Evaluation of glutamate concentration transient in the synaptic
cleft of the rat calyx of Held. Journal of Physiology. Wiley-Blackwell.
https://doi.org/10.1113/jphysiol.2012.241398
chicago: Budisantoso, Timotheus, Harumi Harada, Naomi Kamasawa, Yugo Fukazawa, Ryuichi
Shigemoto, and Ko Matsui. “Evaluation of Glutamate Concentration Transient in
the Synaptic Cleft of the Rat Calyx of Held.” Journal of Physiology. Wiley-Blackwell,
2013. https://doi.org/10.1113/jphysiol.2012.241398.
ieee: T. Budisantoso, H. Harada, N. Kamasawa, Y. Fukazawa, R. Shigemoto, and K.
Matsui, “Evaluation of glutamate concentration transient in the synaptic cleft
of the rat calyx of Held,” Journal of Physiology, vol. 591, no. 1. Wiley-Blackwell,
pp. 219–239, 2013.
ista: Budisantoso T, Harada H, Kamasawa N, Fukazawa Y, Shigemoto R, Matsui K. 2013.
Evaluation of glutamate concentration transient in the synaptic cleft of the rat
calyx of Held. Journal of Physiology. 591(1), 219–239.
mla: Budisantoso, Timotheus, et al. “Evaluation of Glutamate Concentration Transient
in the Synaptic Cleft of the Rat Calyx of Held.” Journal of Physiology,
vol. 591, no. 1, Wiley-Blackwell, 2013, pp. 219–39, doi:10.1113/jphysiol.2012.241398.
short: T. Budisantoso, H. Harada, N. Kamasawa, Y. Fukazawa, R. Shigemoto, K. Matsui,
Journal of Physiology 591 (2013) 219–239.
date_created: 2018-12-11T11:59:05Z
date_published: 2013-01-01T00:00:00Z
date_updated: 2021-01-12T06:59:04Z
day: '01'
doi: 10.1113/jphysiol.2012.241398
extern: 1
intvolume: ' 591'
issue: '1'
month: '01'
page: 219 - 239
publication: Journal of Physiology
publication_status: published
publisher: Wiley-Blackwell
publist_id: '4207'
quality_controlled: 0
status: public
title: Evaluation of glutamate concentration transient in the synaptic cleft of the
rat calyx of Held
type: journal_article
volume: 591
year: '2013'
...
---
_id: '2693'
abstract:
- lang: eng
text: Inhibitory parvalbumin-containing interneurons (PVIs) control neuronal discharge
and support the generation of theta- and gammafrequency oscillations in cortical
networks. Fast GABAergic input onto PVIs is crucial for their synchronization
and oscillatory entrainment, but the role of metabotropic GABAB receptors (GABABRs)
in mediating slow presynaptic and postsynaptic inhibition remains unknown. In
this study, we have combined high-resolution immunoelectron microscopy, whole-cell
patch-clamp recording, and computational modeling to investigate the subcellular
distribution and effects of GABABRs and their postsynaptic effector Kir3 channels
in rat hippocampal PVIs. Pre-embedding immunogold labeling revealed that the receptors
and channels localize at high levels to the extrasynaptic membrane of parvalbumin-immunoreactive
dendrites. Immunoreactivity forGABABRs was also present at lower levels on PVI
axon terminals. Whole-cell recordings further showed that synaptically released
GABA in response to extracellular stimulation evokes large GABABR-mediated slow
IPSCs in perisomatic-targeting (PT) PVIs, but only small or no currents in dendrite-targeting
(DT) PVIs. In contrast, paired recordings demonstrated that GABABR activation
results in presynaptic inhibition at the output synapses of both PT and DT PVIs,
but more strongly in the latter. Finally, computational analysis indicated that
GABAB IPSCs can phasically modulate the discharge of PT interneurons at theta
frequencies. In summary, our results show that GABABRs differentially mediate
slow presynaptic and postsynaptic inhibition in PVIs and can contribute to the
dynamic modulation of their activity during oscillations. Furthermore, these data
provide evidence for a compartment-specific molecular divergence of hippocampal
PVI subtypes, suggesting that activation of GABABRs may shift the balance between
perisomatic and dendritic inhibition.
author:
- first_name: Sam
full_name: Booker, Sam A
last_name: Booker
- first_name: Anna
full_name: Gross, Anna
last_name: Gross
- first_name: Daniel
full_name: Althof, Daniel
last_name: Althof
- first_name: Ryuichi
full_name: Ryuichi Shigemoto
id: 499F3ABC-F248-11E8-B48F-1D18A9856A87
last_name: Shigemoto
orcid: 0000-0001-8761-9444
- first_name: Bernhard
full_name: Bettler, Bernhard
last_name: Bettler
- first_name: Michael
full_name: Frotscher, Michael
last_name: Frotscher
- first_name: Matthew
full_name: Hearing, Matthew C
last_name: Hearing
- first_name: Kevin
full_name: Wickman, Kevin D
last_name: Wickman
- first_name: Masahiko
full_name: Watanabe, Masahiko
last_name: Watanabe
- first_name: Ákos
full_name: Kulik, Ákos
last_name: Kulik
- first_name: Imre
full_name: Vida, Imre
last_name: Vida
citation:
ama: Booker S, Gross A, Althof D, et al. Differential GABAB-receptor-mediated effects
in perisomatic- and dendrite-targeting parvalbumin interneurons. Journal of
Neuroscience. 2013;33(18):7961-7974. doi:10.1523/JNEUROSCI.1186-12.2013
apa: Booker, S., Gross, A., Althof, D., Shigemoto, R., Bettler, B., Frotscher, M.,
… Vida, I. (2013). Differential GABAB-receptor-mediated effects in perisomatic-
and dendrite-targeting parvalbumin interneurons. Journal of Neuroscience.
Society for Neuroscience. https://doi.org/10.1523/JNEUROSCI.1186-12.2013
chicago: Booker, Sam, Anna Gross, Daniel Althof, Ryuichi Shigemoto, Bernhard Bettler,
Michael Frotscher, Matthew Hearing, et al. “Differential GABAB-Receptor-Mediated
Effects in Perisomatic- and Dendrite-Targeting Parvalbumin Interneurons.” Journal
of Neuroscience. Society for Neuroscience, 2013. https://doi.org/10.1523/JNEUROSCI.1186-12.2013.
ieee: S. Booker et al., “Differential GABAB-receptor-mediated effects in
perisomatic- and dendrite-targeting parvalbumin interneurons,” Journal of Neuroscience,
vol. 33, no. 18. Society for Neuroscience, pp. 7961–7974, 2013.
ista: Booker S, Gross A, Althof D, Shigemoto R, Bettler B, Frotscher M, Hearing
M, Wickman K, Watanabe M, Kulik Á, Vida I. 2013. Differential GABAB-receptor-mediated
effects in perisomatic- and dendrite-targeting parvalbumin interneurons. Journal
of Neuroscience. 33(18), 7961–7974.
mla: Booker, Sam, et al. “Differential GABAB-Receptor-Mediated Effects in Perisomatic-
and Dendrite-Targeting Parvalbumin Interneurons.” Journal of Neuroscience,
vol. 33, no. 18, Society for Neuroscience, 2013, pp. 7961–74, doi:10.1523/JNEUROSCI.1186-12.2013.
short: S. Booker, A. Gross, D. Althof, R. Shigemoto, B. Bettler, M. Frotscher, M.
Hearing, K. Wickman, M. Watanabe, Á. Kulik, I. Vida, Journal of Neuroscience 33
(2013) 7961–7974.
date_created: 2018-12-11T11:59:06Z
date_published: 2013-05-01T00:00:00Z
date_updated: 2021-01-12T06:59:05Z
day: '01'
doi: 10.1523/JNEUROSCI.1186-12.2013
extern: 1
intvolume: ' 33'
issue: '18'
month: '05'
page: 7961 - 7974
publication: Journal of Neuroscience
publication_status: published
publisher: Society for Neuroscience
publist_id: '4204'
quality_controlled: 0
status: public
title: Differential GABAB-receptor-mediated effects in perisomatic- and dendrite-targeting
parvalbumin interneurons
type: journal_article
volume: 33
year: '2013'
...
---
_id: '2698'
abstract:
- lang: eng
text: We consider non-interacting particles subject to a fixed external potential
V and a self-generated magnetic field B. The total energy includes the field energy
β∫B2 and we minimize over all particle states and magnetic fields. In the case
of spin-1/2 particles this minimization leads to the coupled Maxwell-Pauli system.
The parameter β tunes the coupling strength between the field and the particles
and it effectively determines the strength of the field. We investigate the stability
and the semiclassical asymptotics, h→0, of the total ground state energy E(β,h,V).
The relevant parameter measuring the field strength in the semiclassical limit
is κ=βh. We are not able to give the exact leading order semiclassical asymptotics
uniformly in κ or even for fixed κ. We do however give upper and lower bounds
on E with almost matching dependence on κ. In the simultaneous limit h→0 and κ→∞
we show that the standard non-magnetic Weyl asymptotics holds. The same result
also holds for the spinless case, i.e. where the Pauli operator is replaced by
the Schrödinger operator.
author:
- first_name: László
full_name: Erdös, László
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Søren
full_name: Fournais, Søren
last_name: Fournais
- first_name: Jan
full_name: Solovej, Jan
last_name: Solovej
citation:
ama: Erdös L, Fournais S, Solovej J. Stability and semiclassics in self-generated
fields. Journal of the European Mathematical Society. 2013;15(6):2093-2113.
doi:10.4171/JEMS/416
apa: Erdös, L., Fournais, S., & Solovej, J. (2013). Stability and semiclassics
in self-generated fields. Journal of the European Mathematical Society.
European Mathematical Society. https://doi.org/10.4171/JEMS/416
chicago: Erdös, László, Søren Fournais, and Jan Solovej. “Stability and Semiclassics
in Self-Generated Fields.” Journal of the European Mathematical Society.
European Mathematical Society, 2013. https://doi.org/10.4171/JEMS/416.
ieee: L. Erdös, S. Fournais, and J. Solovej, “Stability and semiclassics in self-generated
fields,” Journal of the European Mathematical Society, vol. 15, no. 6.
European Mathematical Society, pp. 2093–2113, 2013.
ista: Erdös L, Fournais S, Solovej J. 2013. Stability and semiclassics in self-generated
fields. Journal of the European Mathematical Society. 15(6), 2093–2113.
mla: Erdös, László, et al. “Stability and Semiclassics in Self-Generated Fields.”
Journal of the European Mathematical Society, vol. 15, no. 6, European
Mathematical Society, 2013, pp. 2093–113, doi:10.4171/JEMS/416.
short: L. Erdös, S. Fournais, J. Solovej, Journal of the European Mathematical Society
15 (2013) 2093–2113.
date_created: 2018-12-11T11:59:07Z
date_published: 2013-10-16T00:00:00Z
date_updated: 2021-01-12T06:59:07Z
day: '16'
department:
- _id: LaEr
doi: 10.4171/JEMS/416
external_id:
arxiv:
- '1105.0506'
intvolume: ' 15'
issue: '6'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1105.0506
month: '10'
oa: 1
oa_version: Preprint
page: 2093 - 2113
publication: Journal of the European Mathematical Society
publication_status: published
publisher: European Mathematical Society
publist_id: '4198'
quality_controlled: '1'
status: public
title: Stability and semiclassics in self-generated fields
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 15
year: '2013'
...
---
_id: '2697'
abstract:
- lang: eng
text: We consider Hermitian and symmetric random band matrices H = (h xy ) in d⩾1
d ⩾ 1 dimensions. The matrix entries h xy , indexed by x,y∈(Z/LZ)d x , y ∈ ( Z
/ L Z ) d , are independent, centred random variables with variances sxy=E|hxy|2
s x y = E | h x y | 2 . We assume that s xy is negligible if |x − y| exceeds the
band width W. In one dimension we prove that the eigenvectors of H are delocalized
if W≫L4/5 W ≫ L 4 / 5 . We also show that the magnitude of the matrix entries
|Gxy|2 | G x y | 2 of the resolvent G=G(z)=(H−z)−1 G = G ( z ) = ( H - z ) - 1
is self-averaging and we compute E|Gxy|2 E | G x y | 2 . We show that, as L→∞
L → ∞ and W≫L4/5 W ≫ L 4 / 5 , the behaviour of E|Gxy|2 E | G x y | 2 is governed
by a diffusion operator whose diffusion constant we compute. Similar results are
obtained in higher dimensions.
author:
- first_name: László
full_name: László Erdös
id: 4DBD5372-F248-11E8-B48F-1D18A9856A87
last_name: Erdös
orcid: 0000-0001-5366-9603
- first_name: Antti
full_name: Knowles, Antti
last_name: Knowles
- first_name: Horng
full_name: Yau, Horng-Tzer
last_name: Yau
- first_name: Jun
full_name: Yin, Jun
last_name: Yin
citation:
ama: Erdös L, Knowles A, Yau H, Yin J. Delocalization and diffusion profile for
random band matrices. Communications in Mathematical Physics. 2013;323(1):367-416.
doi:10.1007/s00220-013-1773-3
apa: Erdös, L., Knowles, A., Yau, H., & Yin, J. (2013). Delocalization and diffusion
profile for random band matrices. Communications in Mathematical Physics.
Springer. https://doi.org/10.1007/s00220-013-1773-3
chicago: Erdös, László, Antti Knowles, Horng Yau, and Jun Yin. “Delocalization and
Diffusion Profile for Random Band Matrices.” Communications in Mathematical
Physics. Springer, 2013. https://doi.org/10.1007/s00220-013-1773-3.
ieee: L. Erdös, A. Knowles, H. Yau, and J. Yin, “Delocalization and diffusion profile
for random band matrices,” Communications in Mathematical Physics, vol.
323, no. 1. Springer, pp. 367–416, 2013.
ista: Erdös L, Knowles A, Yau H, Yin J. 2013. Delocalization and diffusion profile
for random band matrices. Communications in Mathematical Physics. 323(1), 367–416.
mla: Erdös, László, et al. “Delocalization and Diffusion Profile for Random Band
Matrices.” Communications in Mathematical Physics, vol. 323, no. 1, Springer,
2013, pp. 367–416, doi:10.1007/s00220-013-1773-3.
short: L. Erdös, A. Knowles, H. Yau, J. Yin, Communications in Mathematical Physics
323 (2013) 367–416.
date_created: 2018-12-11T11:59:07Z
date_published: 2013-10-01T00:00:00Z
date_updated: 2021-01-12T06:59:07Z
day: '01'
doi: 10.1007/s00220-013-1773-3
extern: 1
intvolume: ' 323'
issue: '1'
main_file_link:
- open_access: '1'
url: http://arxiv.org/abs/1205.5669
month: '10'
oa: 1
page: 367 - 416
publication: Communications in Mathematical Physics
publication_status: published
publisher: Springer
publist_id: '4199'
quality_controlled: 0
status: public
title: Delocalization and diffusion profile for random band matrices
type: journal_article
volume: 323
year: '2013'
...
---
_id: '2718'
abstract:
- lang: eng
text: Even though both population and quantitative genetics, and evolutionary computation,
deal with the same questions, they have developed largely independently of each
other. I review key results from each field, emphasising those that apply independently
of the (usually unknown) relation between genotype and phenotype. The infinitesimal
model provides a simple framework for predicting the response of complex traits
to selection, which in biology has proved remarkably successful. This allows one
to choose the schedule of population sizes and selection intensities that will
maximise the response to selection, given that the total number of individuals
realised, C = ∑t Nt, is constrained. This argument shows that for an additive
trait (i.e., determined by the sum of effects of the genes), the optimum population
size and the maximum possible response (i.e., the total change in trait mean)
are both proportional to √C.
author:
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
- first_name: Tiago
full_name: Paixao, Tiago
id: 2C5658E6-F248-11E8-B48F-1D18A9856A87
last_name: Paixao
orcid: 0000-0003-2361-3953
citation:
ama: 'Barton NH, Paixao T. Can quantitative and population genetics help us understand
evolutionary computation? In: Proceedings of the 15th Annual Conference on
Genetic and Evolutionary Computation. ACM; 2013:1573-1580. doi:10.1145/2463372.2463568'
apa: 'Barton, N. H., & Paixao, T. (2013). Can quantitative and population genetics
help us understand evolutionary computation? In Proceedings of the 15th annual
conference on Genetic and evolutionary computation (pp. 1573–1580). Amsterdam,
Netherlands: ACM. https://doi.org/10.1145/2463372.2463568'
chicago: Barton, Nicholas H, and Tiago Paixao. “Can Quantitative and Population
Genetics Help Us Understand Evolutionary Computation?” In Proceedings of the
15th Annual Conference on Genetic and Evolutionary Computation, 1573–80. ACM,
2013. https://doi.org/10.1145/2463372.2463568.
ieee: N. H. Barton and T. Paixao, “Can quantitative and population genetics help
us understand evolutionary computation?,” in Proceedings of the 15th annual
conference on Genetic and evolutionary computation, Amsterdam, Netherlands,
2013, pp. 1573–1580.
ista: 'Barton NH, Paixao T. 2013. Can quantitative and population genetics help
us understand evolutionary computation? Proceedings of the 15th annual conference
on Genetic and evolutionary computation. GECCO: Genetic and evolutionary computation
conference, 1573–1580.'
mla: Barton, Nicholas H., and Tiago Paixao. “Can Quantitative and Population Genetics
Help Us Understand Evolutionary Computation?” Proceedings of the 15th Annual
Conference on Genetic and Evolutionary Computation, ACM, 2013, pp. 1573–80,
doi:10.1145/2463372.2463568.
short: N.H. Barton, T. Paixao, in:, Proceedings of the 15th Annual Conference on
Genetic and Evolutionary Computation, ACM, 2013, pp. 1573–1580.
conference:
end_date: 2013-07-10
location: Amsterdam, Netherlands
name: 'GECCO: Genetic and evolutionary computation conference'
start_date: 2013-07-06
date_created: 2018-12-11T11:59:14Z
date_published: 2013-07-01T00:00:00Z
date_updated: 2021-01-12T06:59:15Z
day: '01'
ddc:
- '570'
department:
- _id: NiBa
- _id: CaGu
doi: 10.1145/2463372.2463568
ec_funded: 1
file:
- access_level: open_access
checksum: 9d9be9090ce5c20766e0eb076ace5b98
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:38Z
date_updated: 2020-07-14T12:45:45Z
file_id: '5159'
file_name: IST-2016-564-v1+1_NickGECCO_2013_1_-1.pdf
file_size: 475844
relation: main_file
file_date_updated: 2020-07-14T12:45:45Z
has_accepted_license: '1'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Submitted Version
page: 1573 - 1580
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
publication: Proceedings of the 15th annual conference on Genetic and evolutionary
computation
publication_status: published
publisher: ACM
publist_id: '4174'
pubrep_id: '564'
quality_controlled: '1'
scopus_import: 1
status: public
title: Can quantitative and population genetics help us understand evolutionary computation?
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2013'
...
---
_id: '2720'
abstract:
- lang: eng
text: 'Knowledge of the rate and fitness effects of mutations is essential for understanding
the process of evolution. Mutations are inherently difficult to study because
they are rare and are frequently eliminated by natural selection. In the ciliate
Tetrahymena thermophila, mutations can accumulate in the germline genome without
being exposed to selection. We have conducted a mutation accumulation (MA) experiment
in this species. Assuming that all mutations are deleterious and have the same
effect, we estimate that the deleterious mutation rate per haploid germline genome
per generation is U = 0.0047 (95% credible interval: 0.0015, 0.0125), and that
germline mutations decrease fitness by s = 11% when expressed in a homozygous
state (95% CI: 4.4%, 27%). We also estimate that deleterious mutations are partially
recessive on average (h = 0.26; 95% CI: –0.022, 0.62) and that the rate of lethal
mutations is <10% of the deleterious mutation rate. Comparisons between the
observed evolutionary responses in the germline and somatic genomes and the results
from individual-based simulations of MA suggest that the two genomes have similar
mutational parameters. These are the first estimates of the deleterious mutation
rate and fitness effects from the eukaryotic supergroup Chromalveolata and are
within the range of those of other eukaryotes.'
article_processing_charge: No
author:
- first_name: Hongan
full_name: Long, Hongan
last_name: Long
- first_name: Tiago
full_name: Paixao, Tiago
id: 2C5658E6-F248-11E8-B48F-1D18A9856A87
last_name: Paixao
orcid: 0000-0003-2361-3953
- first_name: Ricardo
full_name: Azevedo, Ricardo
last_name: Azevedo
- first_name: Rebecca
full_name: Zufall, Rebecca
last_name: Zufall
citation:
ama: Long H, Paixao T, Azevedo R, Zufall R. Accumulation of spontaneous mutations
in the ciliate Tetrahymena thermophila. Genetics. 2013;195(2):527-540.
doi:10.1534/genetics.113.153536
apa: Long, H., Paixao, T., Azevedo, R., & Zufall, R. (2013). Accumulation of
spontaneous mutations in the ciliate Tetrahymena thermophila. Genetics.
Genetics Society of America. https://doi.org/10.1534/genetics.113.153536
chicago: Long, Hongan, Tiago Paixao, Ricardo Azevedo, and Rebecca Zufall. “Accumulation
of Spontaneous Mutations in the Ciliate Tetrahymena Thermophila.” Genetics.
Genetics Society of America, 2013. https://doi.org/10.1534/genetics.113.153536.
ieee: H. Long, T. Paixao, R. Azevedo, and R. Zufall, “Accumulation of spontaneous
mutations in the ciliate Tetrahymena thermophila,” Genetics, vol. 195,
no. 2. Genetics Society of America, pp. 527–540, 2013.
ista: Long H, Paixao T, Azevedo R, Zufall R. 2013. Accumulation of spontaneous mutations
in the ciliate Tetrahymena thermophila. Genetics. 195(2), 527–540.
mla: Long, Hongan, et al. “Accumulation of Spontaneous Mutations in the Ciliate
Tetrahymena Thermophila.” Genetics, vol. 195, no. 2, Genetics Society of
America, 2013, pp. 527–40, doi:10.1534/genetics.113.153536.
short: H. Long, T. Paixao, R. Azevedo, R. Zufall, Genetics 195 (2013) 527–540.
date_created: 2018-12-11T11:59:15Z
date_published: 2013-10-01T00:00:00Z
date_updated: 2021-01-12T06:59:16Z
day: '01'
department:
- _id: NiBa
- _id: CaGu
doi: 10.1534/genetics.113.153536
ec_funded: 1
external_id:
pmid:
- '23934880'
intvolume: ' 195'
issue: '2'
language:
- iso: eng
main_file_link:
- open_access: '1'
url: http://www.ncbi.nlm.nih.gov/pmc/articles/PMC3781978/
month: '10'
oa: 1
oa_version: Submitted Version
page: 527-540
pmid: 1
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
publication: Genetics
publication_status: published
publisher: Genetics Society of America
publist_id: '4172'
quality_controlled: '1'
scopus_import: 1
status: public
title: Accumulation of spontaneous mutations in the ciliate Tetrahymena thermophila
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 195
year: '2013'
...
---
_id: '2719'
abstract:
- lang: eng
text: Prediction of the evolutionary process is a long standing problem both in
the theory of evolutionary biology and evolutionary computation (EC). It has long
been realized that heritable variation is crucial to both the response to selection
and the success of genetic algorithms. However, not all variation contributes
in the same way to the response. Quantitative genetics has developed a large body
of work trying to estimate and understand how different components of the variance
in fitness in the population contribute to the response to selection. We illustrate
how to apply some concepts of quantitative genetics to the analysis of genetic
algorithms. In particular, we derive estimates for the short term prediction of
the response to selection and we use variance decomposition to gain insight on
local aspects of the landscape. Finally, we propose a new population based genetic
algorithm that uses these methods to improve its operation.
author:
- first_name: Tiago
full_name: Paixao, Tiago
id: 2C5658E6-F248-11E8-B48F-1D18A9856A87
last_name: Paixao
orcid: 0000-0003-2361-3953
- first_name: Nicholas H
full_name: Barton, Nicholas H
id: 4880FE40-F248-11E8-B48F-1D18A9856A87
last_name: Barton
orcid: 0000-0002-8548-5240
citation:
ama: 'Paixao T, Barton NH. A variance decomposition approach to the analysis of
genetic algorithms. In: Proceedings of the 15th Annual Conference on Genetic
and Evolutionary Computation. ACM; 2013:845-852. doi:10.1145/2463372.2463470'
apa: 'Paixao, T., & Barton, N. H. (2013). A variance decomposition approach
to the analysis of genetic algorithms. In Proceedings of the 15th annual conference
on Genetic and evolutionary computation (pp. 845–852). Amsterdam, Netherlands:
ACM. https://doi.org/10.1145/2463372.2463470'
chicago: Paixao, Tiago, and Nicholas H Barton. “A Variance Decomposition Approach
to the Analysis of Genetic Algorithms.” In Proceedings of the 15th Annual Conference
on Genetic and Evolutionary Computation, 845–52. ACM, 2013. https://doi.org/10.1145/2463372.2463470.
ieee: T. Paixao and N. H. Barton, “A variance decomposition approach to the analysis
of genetic algorithms,” in Proceedings of the 15th annual conference on Genetic
and evolutionary computation, Amsterdam, Netherlands, 2013, pp. 845–852.
ista: 'Paixao T, Barton NH. 2013. A variance decomposition approach to the analysis
of genetic algorithms. Proceedings of the 15th annual conference on Genetic and
evolutionary computation. GECCO: Genetic and evolutionary computation conference,
845–852.'
mla: Paixao, Tiago, and Nicholas H. Barton. “A Variance Decomposition Approach to
the Analysis of Genetic Algorithms.” Proceedings of the 15th Annual Conference
on Genetic and Evolutionary Computation, ACM, 2013, pp. 845–52, doi:10.1145/2463372.2463470.
short: T. Paixao, N.H. Barton, in:, Proceedings of the 15th Annual Conference on
Genetic and Evolutionary Computation, ACM, 2013, pp. 845–852.
conference:
end_date: 2013-07-10
location: Amsterdam, Netherlands
name: 'GECCO: Genetic and evolutionary computation conference'
start_date: 2013-07-06
date_created: 2018-12-11T11:59:15Z
date_published: 2013-07-01T00:00:00Z
date_updated: 2021-01-12T06:59:15Z
day: '01'
department:
- _id: NiBa
- _id: CaGu
doi: 10.1145/2463372.2463470
ec_funded: 1
language:
- iso: eng
month: '07'
oa_version: None
page: 845 - 852
project:
- _id: 25B07788-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '250152'
name: Limits to selection in biology and in evolutionary computation
publication: Proceedings of the 15th annual conference on Genetic and evolutionary
computation
publication_status: published
publisher: ACM
publist_id: '4173'
quality_controlled: '1'
scopus_import: 1
status: public
title: A variance decomposition approach to the analysis of genetic algorithms
type: conference
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
year: '2013'
...