---
_id: '245'
abstract:
- lang: eng
text: For given non-zero integers a, b, q we investigate the density of solutions
(x; y) ∈ ℤ2 to the binary cubic congruence ax2 + by3 ≡ 0 mod q, and use it to
establish the Manin conjecture for a singular del Pezzo surface of degree 2 defined
over ℚ.
author:
- first_name: Stephan
full_name: Baier, Stephan
last_name: Baier
- first_name: Timothy D
full_name: Timothy Browning
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
citation:
ama: Baier S, Browning TD. Inhomogeneous cubic congruences and rational points on
del Pezzo surfaces. Journal fur die Reine und Angewandte Mathematik. 2013;(680):69-151.
doi:10.1515/crelle.2012.039
apa: Baier, S., & Browning, T. D. (2013). Inhomogeneous cubic congruences and
rational points on del Pezzo surfaces. Journal Fur Die Reine Und Angewandte
Mathematik. Walter de Gruyter. https://doi.org/10.1515/crelle.2012.039
chicago: Baier, Stephan, and Timothy D Browning. “Inhomogeneous Cubic Congruences
and Rational Points on Del Pezzo Surfaces.” Journal Fur Die Reine Und Angewandte
Mathematik. Walter de Gruyter, 2013. https://doi.org/10.1515/crelle.2012.039.
ieee: S. Baier and T. D. Browning, “Inhomogeneous cubic congruences and rational
points on del Pezzo surfaces,” Journal fur die Reine und Angewandte Mathematik,
no. 680. Walter de Gruyter, pp. 69–151, 2013.
ista: Baier S, Browning TD. 2013. Inhomogeneous cubic congruences and rational points
on del Pezzo surfaces. Journal fur die Reine und Angewandte Mathematik. (680),
69–151.
mla: Baier, Stephan, and Timothy D. Browning. “Inhomogeneous Cubic Congruences and
Rational Points on Del Pezzo Surfaces.” Journal Fur Die Reine Und Angewandte
Mathematik, no. 680, Walter de Gruyter, 2013, pp. 69–151, doi:10.1515/crelle.2012.039.
short: S. Baier, T.D. Browning, Journal Fur Die Reine Und Angewandte Mathematik
(2013) 69–151.
date_created: 2018-12-11T11:45:24Z
date_published: 2013-07-01T00:00:00Z
date_updated: 2021-01-12T06:57:33Z
day: '01'
doi: 10.1515/crelle.2012.039
extern: 1
issue: '680'
main_file_link:
- open_access: '1'
url: https://arxiv.org/abs/1011.3434
month: '07'
oa: 1
page: 69 - 151
publication: Journal fur die Reine und Angewandte Mathematik
publication_status: published
publisher: Walter de Gruyter
publist_id: '7659'
quality_controlled: 0
status: public
title: Inhomogeneous cubic congruences and rational points on del Pezzo surfaces
type: journal_article
year: '2013'
...
---
_id: '2457'
author:
- first_name: Tom
full_name: Viaene, Tom
last_name: Viaene
- first_name: Charles
full_name: Delwiche, Charles
last_name: Delwiche
- first_name: Stefan
full_name: Rensing, Stefan
last_name: Rensing
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
citation:
ama: Viaene T, Delwiche C, Rensing S, Friml J. Origin and evolution of PIN auxin
transporters in the green lineage. Trends in Plant Science. 2013;18(1):5-10.
doi:10.1016/j.tplants.2012.08.009
apa: Viaene, T., Delwiche, C., Rensing, S., & Friml, J. (2013). Origin and evolution
of PIN auxin transporters in the green lineage. Trends in Plant Science.
Cell Press. https://doi.org/10.1016/j.tplants.2012.08.009
chicago: Viaene, Tom, Charles Delwiche, Stefan Rensing, and Jiří Friml. “Origin
and Evolution of PIN Auxin Transporters in the Green Lineage.” Trends in Plant
Science. Cell Press, 2013. https://doi.org/10.1016/j.tplants.2012.08.009.
ieee: T. Viaene, C. Delwiche, S. Rensing, and J. Friml, “Origin and evolution of
PIN auxin transporters in the green lineage,” Trends in Plant Science,
vol. 18, no. 1. Cell Press, pp. 5–10, 2013.
ista: Viaene T, Delwiche C, Rensing S, Friml J. 2013. Origin and evolution of PIN
auxin transporters in the green lineage. Trends in Plant Science. 18(1), 5–10.
mla: Viaene, Tom, et al. “Origin and Evolution of PIN Auxin Transporters in the
Green Lineage.” Trends in Plant Science, vol. 18, no. 1, Cell Press, 2013,
pp. 5–10, doi:10.1016/j.tplants.2012.08.009.
short: T. Viaene, C. Delwiche, S. Rensing, J. Friml, Trends in Plant Science 18
(2013) 5–10.
date_created: 2018-12-11T11:57:46Z
date_published: 2013-01-01T00:00:00Z
date_updated: 2021-01-12T06:57:36Z
day: '01'
doi: 10.1016/j.tplants.2012.08.009
extern: '1'
intvolume: ' 18'
issue: '1'
language:
- iso: eng
month: '01'
oa_version: None
page: 5 - 10
publication: Trends in Plant Science
publication_status: published
publisher: Cell Press
publist_id: '4446'
quality_controlled: '1'
status: public
title: Origin and evolution of PIN auxin transporters in the green lineage
type: journal_article
user_id: 3E5EF7F0-F248-11E8-B48F-1D18A9856A87
volume: 18
year: '2013'
...
---
_id: '246'
abstract:
- lang: eng
text: Given an intersection of two quadrics X Pm1, with m > 9, the quantitative
arithmetic of the set X(Q) is investigated under the assumption that the singular
locus of X consists of a pair of conjugate singular points defined over Q(i).
acknowledgement: "EP/E053262/1\tEngineering and Physical Sciences Research Council"
author:
- first_name: Timothy D
full_name: Timothy Browning
id: 35827D50-F248-11E8-B48F-1D18A9856A87
last_name: Browning
orcid: 0000-0002-8314-0177
- first_name: Ritabrata
full_name: Munshi, Ritabrata
last_name: Munshi
citation:
ama: Browning TD, Munshi R. Rational points on singular intersections of quadrics.
Compositio Mathematica. 2013;149(9):1457-1494. doi:10.1112/S0010437X13007185
apa: Browning, T. D., & Munshi, R. (2013). Rational points on singular intersections
of quadrics. Compositio Mathematica. Cambridge University Press. https://doi.org/10.1112/S0010437X13007185
chicago: Browning, Timothy D, and Ritabrata Munshi. “Rational Points on Singular
Intersections of Quadrics.” Compositio Mathematica. Cambridge University
Press, 2013. https://doi.org/10.1112/S0010437X13007185.
ieee: T. D. Browning and R. Munshi, “Rational points on singular intersections of
quadrics,” Compositio Mathematica, vol. 149, no. 9. Cambridge University
Press, pp. 1457–1494, 2013.
ista: Browning TD, Munshi R. 2013. Rational points on singular intersections of
quadrics. Compositio Mathematica. 149(9), 1457–1494.
mla: Browning, Timothy D., and Ritabrata Munshi. “Rational Points on Singular Intersections
of Quadrics.” Compositio Mathematica, vol. 149, no. 9, Cambridge University
Press, 2013, pp. 1457–94, doi:10.1112/S0010437X13007185.
short: T.D. Browning, R. Munshi, Compositio Mathematica 149 (2013) 1457–1494.
date_created: 2018-12-11T11:45:25Z
date_published: 2013-09-01T00:00:00Z
date_updated: 2021-01-12T06:57:37Z
day: '01'
doi: 10.1112/S0010437X13007185
extern: 1
intvolume: ' 149'
issue: '9'
month: '09'
page: 1457 - 1494
publication: Compositio Mathematica
publication_status: published
publisher: Cambridge University Press
publist_id: '7658'
quality_controlled: 0
status: public
title: Rational points on singular intersections of quadrics
type: journal_article
volume: 149
year: '2013'
...
---
_id: '2471'
abstract:
- lang: eng
text: The impact of disulfide bonds on protein stability goes beyond simple equilibrium
thermodynamics effects associated with the conformational entropy of the unfolded
state. Indeed, disulfide crosslinks may play a role in the prevention of dysfunctional
association and strongly affect the rates of irreversible enzyme inactivation,
highly relevant in biotechnological applications. While these kinetic-stability
effects remain poorly understood, by analogy with proposed mechanisms for processes
of protein aggregation and fibrillogenesis, we propose that they may be determined
by the properties of sparsely-populated, partially-unfolded intermediates. Here
we report the successful design, on the basis of high temperature molecular-dynamics
simulations, of six thermodynamically and kinetically stabilized variants of phytase
from Citrobacter braakii (a biotechnologically important enzyme) with one, two
or three engineered disulfides. Activity measurements and 3D crystal structure
determination demonstrate that the engineered crosslinks do not cause dramatic
alterations in the native structure. The inactivation kinetics for all the variants
displays a strongly non-Arrhenius temperature dependence, with the time-scale
for the irreversible denaturation process reaching a minimum at a given temperature
within the range of the denaturation transition. We show this striking feature
to be a signature of a key role played by a partially unfolded, intermediate state/ensemble.
Energetic and mutational analyses confirm that the intermediate is highly unfolded
(akin to a proposed critical intermediate in the misfolding of the prion protein),
a result that explains the observed kinetic stabilization. Our results provide
a rationale for the kinetic-stability consequences of disulfide-crosslink engineering
and an experimental methodology to arrive at energetic/structural descriptions
of the sparsely populated and elusive intermediates that play key roles in irreversible
protein denaturation.
article_number: e70013
author:
- first_name: Inmaculada
full_name: Sanchez Romero, Inmaculada
id: 3D9C5D30-F248-11E8-B48F-1D18A9856A87
last_name: Sanchez Romero
- first_name: Antonio
full_name: Ariza, Antonio
last_name: Ariza
- first_name: Keith
full_name: Wilson, Keith
last_name: Wilson
- first_name: Michael
full_name: Skjøt, Michael
last_name: Skjøt
- first_name: Jesper
full_name: Vind, Jesper
last_name: Vind
- first_name: Leonardo
full_name: De Maria, Leonardo
last_name: De Maria
- first_name: Lars
full_name: Skov, Lars
last_name: Skov
- first_name: Jose
full_name: Sánchez Ruiz, Jose
last_name: Sánchez Ruiz
citation:
ama: Sanchez-Romero I, Ariza A, Wilson K, et al. Mechanism of protein kinetic stabilization
by engineered disulfide crosslinks. PLoS One. 2013;8(7). doi:10.1371/journal.pone.0070013
apa: Sanchez-Romero, I., Ariza, A., Wilson, K., Skjøt, M., Vind, J., De Maria, L.,
… Sánchez Ruiz, J. (2013). Mechanism of protein kinetic stabilization by engineered
disulfide crosslinks. PLoS One. Public Library of Science. https://doi.org/10.1371/journal.pone.0070013
chicago: Sanchez-Romero, Inmaculada, Antonio Ariza, Keith Wilson, Michael Skjøt,
Jesper Vind, Leonardo De Maria, Lars Skov, and Jose Sánchez Ruiz. “Mechanism of
Protein Kinetic Stabilization by Engineered Disulfide Crosslinks.” PLoS One.
Public Library of Science, 2013. https://doi.org/10.1371/journal.pone.0070013.
ieee: I. Sanchez-Romero et al., “Mechanism of protein kinetic stabilization
by engineered disulfide crosslinks,” PLoS One, vol. 8, no. 7. Public Library
of Science, 2013.
ista: Sanchez-Romero I, Ariza A, Wilson K, Skjøt M, Vind J, De Maria L, Skov L,
Sánchez Ruiz J. 2013. Mechanism of protein kinetic stabilization by engineered
disulfide crosslinks. PLoS One. 8(7), e70013.
mla: Sanchez-Romero, Inmaculada, et al. “Mechanism of Protein Kinetic Stabilization
by Engineered Disulfide Crosslinks.” PLoS One, vol. 8, no. 7, e70013, Public
Library of Science, 2013, doi:10.1371/journal.pone.0070013.
short: I. Sanchez-Romero, A. Ariza, K. Wilson, M. Skjøt, J. Vind, L. De Maria, L.
Skov, J. Sánchez Ruiz, PLoS One 8 (2013).
date_created: 2018-12-11T11:57:51Z
date_published: 2013-07-30T00:00:00Z
date_updated: 2021-01-12T06:57:41Z
day: '30'
ddc:
- '570'
department:
- _id: HaJa
doi: 10.1371/journal.pone.0070013
file:
- access_level: open_access
checksum: c0c96cc76ed7ef0d036a31a7e33c9a37
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:15:07Z
date_updated: 2020-07-14T12:45:41Z
file_id: '5124'
file_name: IST-2016-414-v1+1_journal.pone.0070013.pdf
file_size: 1323666
relation: main_file
file_date_updated: 2020-07-14T12:45:41Z
has_accepted_license: '1'
intvolume: ' 8'
issue: '7'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '4430'
pubrep_id: '414'
quality_controlled: '1'
scopus_import: 1
status: public
title: Mechanism of protein kinetic stabilization by engineered disulfide crosslinks
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2013'
...
---
_id: '2472'
abstract:
- lang: eng
text: Plant-specific PIN-formed (PIN) efflux transporters for the plant hormone
auxin are required for tissue-specific directional auxin transport and cellular
auxin homeostasis. The Arabidopsis PIN protein family has been shown to play important
roles in developmental processes such as embryogenesis, organogenesis, vascular
tissue differentiation, root meristem patterning and tropic growth. Here we analyzed
roles of the less characterised Arabidopsis PIN6 auxin transporter. PIN6 is auxin-inducible
and is expressed during multiple auxin-regulated developmental processes. Loss
of pin6 function interfered with primary root growth and lateral root development.
Misexpression of PIN6 affected auxin transport and interfered with auxin homeostasis
in other growth processes such as shoot apical dominance, lateral root primordia
development, adventitious root formation, root hair outgrowth and root waving.
These changes in auxin-regulated growth correlated with a reduction in total auxin
transport as well as with an altered activity of DR5-GUS auxin response reporter.
Overall, the data indicate that PIN6 regulates auxin homeostasis during plant
development.
article_number: e70069
author:
- first_name: Christopher
full_name: Cazzonelli, Christopher
last_name: Cazzonelli
- first_name: Marleen
full_name: Vanstraelen, Marleen
last_name: Vanstraelen
- first_name: Sibu
full_name: Simon, Sibu
id: 4542EF9A-F248-11E8-B48F-1D18A9856A87
last_name: Simon
orcid: 0000-0002-1998-6741
- first_name: Kuide
full_name: Yin, Kuide
last_name: Yin
- first_name: Ashley
full_name: Carron Arthur, Ashley
last_name: Carron Arthur
- first_name: Nazia
full_name: Nisar, Nazia
last_name: Nisar
- first_name: Gauri
full_name: Tarle, Gauri
last_name: Tarle
- first_name: Abby
full_name: Cuttriss, Abby
last_name: Cuttriss
- first_name: Iain
full_name: Searle, Iain
last_name: Searle
- first_name: Eva
full_name: Benková, Eva
id: 38F4F166-F248-11E8-B48F-1D18A9856A87
last_name: Benková
orcid: 0000-0002-8510-9739
- first_name: Ulrike
full_name: Mathesius, Ulrike
last_name: Mathesius
- first_name: Josette
full_name: Masle, Josette
last_name: Masle
- first_name: Jirí
full_name: Friml, Jirí
id: 4159519E-F248-11E8-B48F-1D18A9856A87
last_name: Friml
orcid: 0000-0002-8302-7596
- first_name: Barry
full_name: Pogson, Barry
last_name: Pogson
citation:
ama: Cazzonelli C, Vanstraelen M, Simon S, et al. Role of the Arabidopsis PIN6 auxin
transporter in auxin homeostasis and auxin-mediated development. PLoS One.
2013;8(7). doi:10.1371/journal.pone.0070069
apa: Cazzonelli, C., Vanstraelen, M., Simon, S., Yin, K., Carron Arthur, A., Nisar,
N., … Pogson, B. (2013). Role of the Arabidopsis PIN6 auxin transporter in auxin
homeostasis and auxin-mediated development. PLoS One. Public Library of
Science. https://doi.org/10.1371/journal.pone.0070069
chicago: Cazzonelli, Christopher, Marleen Vanstraelen, Sibu Simon, Kuide Yin, Ashley
Carron Arthur, Nazia Nisar, Gauri Tarle, et al. “Role of the Arabidopsis PIN6
Auxin Transporter in Auxin Homeostasis and Auxin-Mediated Development.” PLoS
One. Public Library of Science, 2013. https://doi.org/10.1371/journal.pone.0070069.
ieee: C. Cazzonelli et al., “Role of the Arabidopsis PIN6 auxin transporter
in auxin homeostasis and auxin-mediated development,” PLoS One, vol. 8,
no. 7. Public Library of Science, 2013.
ista: Cazzonelli C, Vanstraelen M, Simon S, Yin K, Carron Arthur A, Nisar N, Tarle
G, Cuttriss A, Searle I, Benková E, Mathesius U, Masle J, Friml J, Pogson B. 2013.
Role of the Arabidopsis PIN6 auxin transporter in auxin homeostasis and auxin-mediated
development. PLoS One. 8(7), e70069.
mla: Cazzonelli, Christopher, et al. “Role of the Arabidopsis PIN6 Auxin Transporter
in Auxin Homeostasis and Auxin-Mediated Development.” PLoS One, vol. 8,
no. 7, e70069, Public Library of Science, 2013, doi:10.1371/journal.pone.0070069.
short: C. Cazzonelli, M. Vanstraelen, S. Simon, K. Yin, A. Carron Arthur, N. Nisar,
G. Tarle, A. Cuttriss, I. Searle, E. Benková, U. Mathesius, J. Masle, J. Friml,
B. Pogson, PLoS One 8 (2013).
date_created: 2018-12-11T11:57:52Z
date_published: 2013-07-29T00:00:00Z
date_updated: 2021-01-12T06:57:41Z
day: '29'
ddc:
- '580'
- '570'
department:
- _id: JiFr
- _id: EvBe
doi: 10.1371/journal.pone.0070069
ec_funded: 1
file:
- access_level: open_access
checksum: 3be71828b6c2ba9c90eb7056e3f7f57a
content_type: application/pdf
creator: system
date_created: 2018-12-12T10:16:34Z
date_updated: 2020-07-14T12:45:41Z
file_id: '5222'
file_name: IST-2015-393-v1+1_journal.pone.0070069.pdf
file_size: 9003465
relation: main_file
file_date_updated: 2020-07-14T12:45:41Z
has_accepted_license: '1'
intvolume: ' 8'
issue: '7'
language:
- iso: eng
month: '07'
oa: 1
oa_version: Published Version
project:
- _id: 253FCA6A-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '207362'
name: Hormonal cross-talk in plant organogenesis
- _id: 25716A02-B435-11E9-9278-68D0E5697425
call_identifier: FP7
grant_number: '282300'
name: Polarity and subcellular dynamics in plants
publication: PLoS One
publication_status: published
publisher: Public Library of Science
publist_id: '4431'
pubrep_id: '393'
quality_controlled: '1'
scopus_import: 1
status: public
title: Role of the Arabidopsis PIN6 auxin transporter in auxin homeostasis and auxin-mediated
development
tmp:
image: /images/cc_by.png
legal_code_url: https://creativecommons.org/licenses/by/4.0/legalcode
name: Creative Commons Attribution 4.0 International Public License (CC-BY 4.0)
short: CC BY (4.0)
type: journal_article
user_id: 2DF688A6-F248-11E8-B48F-1D18A9856A87
volume: 8
year: '2013'
...